BindingDB Reactant_set_id Ligand SMILES Ligand InChI Ligand InChI Key BindingDB MonomerID BindingDB Ligand Name Target Name Target Source Organism According to Curator or DataSource Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) kon (M-1-s-1) koff (s-1) pH Temp (C) Curation/DataSource Article DOI BindingDB Entry DOI PMID PubChem AID Patent Number Authors Institution Link to Ligand in BindingDB Link to Target in BindingDB Link to Ligand-Target Pair in BindingDB Ligand HET ID in PDB PDB ID(s) for Ligand-Target Complex PubChem CID of Ligand PubChem SID of Ligand ChEBI ID of Ligand ChEMBL ID of Ligand DrugBank ID of Ligand IUPHAR_GRAC ID of Ligand KEGG ID of Ligand ZINC ID of Ligand Number of Protein Chains in Target (>1 implies a multichain complex) BindingDB Target Chain Sequence PDB ID(s) of Target Chain UniProt (SwissProt) Recommended Name of Target Chain UniProt (SwissProt) Entry Name of Target Chain UniProt (SwissProt) Primary ID of Target Chain UniProt (SwissProt) Secondary ID(s) of Target Chain UniProt (SwissProt) Alternative ID(s) of Target Chain UniProt (TrEMBL) Submitted Name of Target Chain UniProt (TrEMBL) Entry Name of Target Chain UniProt (TrEMBL) Primary ID of Target Chain UniProt (TrEMBL) Secondary ID(s) of Target Chain UniProt (TrEMBL) Alternative ID(s) of Target Chain 440542 Fc1ccc(cc1)S(=O)(=O)C1(CCN(Cc2ccccc2)C1)c1ccc(cc1)C(OCc1ccccc1)(C(F)(F)F)C(F)(F)F InChI=1S/C33H28F7NO3S/c34-28-15-17-29(18-16-28)45(42,43)30(19-20-41(23-30)21-24-7-3-1-4-8-24)26-11-13-27(14-12-26)31(32(35,36)37,33(38,39)40)44-22-25-9-5-2-6-10-25/h1-18H,19-23H2 YPZIRZMNUUQPBO-UHFFFAOYSA-N 253045 US9458171, 1 Nuclear receptor ROR-gamma [262-507] 2753 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253045 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253045&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118207855 346547413 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440543 Fc1ccc(cc1)S(=O)(=O)[C@]1(CCN(Cc2ccccc2)C1)c1ccc(cc1)C(OCc1ccccc1)(C(F)(F)F)C(F)(F)F InChI=1S/C33H28F7NO3S/c34-28-15-17-29(18-16-28)45(42,43)30(19-20-41(23-30)21-24-7-3-1-4-8-24)26-11-13-27(14-12-26)31(32(35,36)37,33(38,39)40)44-22-25-9-5-2-6-10-25/h1-18H,19-23H2/t30-/m0/s1 YPZIRZMNUUQPBO-PMERELPUSA-N 253046 US9458171, 2 Nuclear receptor ROR-gamma [262-507] 1947 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253046 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253046&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118207852 346547414 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440544 OC(c1ccc(cc1)[C@@]1(CCNC1)S(=O)(=O)c1ccc(F)cc1)(C(F)(F)F)C(F)(F)F InChI=1S/C19H16F7NO3S/c20-14-5-7-15(8-6-14)31(29,30)16(9-10-27-11-16)12-1-3-13(4-2-12)17(28,18(21,22)23)19(24,25)26/h1-8,27-28H,9-11H2/t16-/m0/s1 OMYNIZMYRGKJIF-INIZCTEOSA-N 253047 US9458171, 3 Nuclear receptor ROR-gamma [262-507] 35 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253047 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253047&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118208079 346547415 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440545 OC(c1ccc(cc1)[C@]1(CCNC1)S(=O)(=O)c1ccc(F)cc1)(C(F)(F)F)C(F)(F)F InChI=1S/C19H16F7NO3S/c20-14-5-7-15(8-6-14)31(29,30)16(9-10-27-11-16)12-1-3-13(4-2-12)17(28,18(21,22)23)19(24,25)26/h1-8,27-28H,9-11H2/t16-/m1/s1 OMYNIZMYRGKJIF-MRXNPFEDSA-N 253048 US9458171, 4 Nuclear receptor ROR-gamma [262-507] 227 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253048 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253048&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118208092 346547416 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440546 OC(c1ccc(cc1)C1(CCNC1)S(=O)(=O)c1ccc(F)cc1)(C(F)(F)F)C(F)(F)F InChI=1S/C19H16F7NO3S/c20-14-5-7-15(8-6-14)31(29,30)16(9-10-27-11-16)12-1-3-13(4-2-12)17(28,18(21,22)23)19(24,25)26/h1-8,27-28H,9-11H2 OMYNIZMYRGKJIF-UHFFFAOYSA-N 253049 US9458171, 5 Nuclear receptor ROR-gamma [262-507] 194 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253049 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253049&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118207990 346547417 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440547 Fc1ccc(cc1)S(=O)(=O)C1(CCN(Cc2ccccc2)C1)c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F InChI=1S/C33H26F9NO3S/c34-25-13-15-26(16-14-25)47(44,45)30(17-18-43(21-30)19-22-5-2-1-3-6-22)23-9-11-24(12-10-23)31(32(37,38)39,33(40,41)42)46-20-27-28(35)7-4-8-29(27)36/h1-16H,17-21H2 QBZUNJBECOFGLX-UHFFFAOYSA-N 253050 US9458171, 6 Nuclear receptor ROR-gamma [262-507] 704 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253050 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253050&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118207859 346547418 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440548 Fc1ccc(cc1)S(=O)(=O)C1(CCN(C1)C(=O)OCc1ccccc1)c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F InChI=1S/C34H26F9NO5S/c35-25-13-15-26(16-14-25)50(46,47)31(17-18-44(21-31)30(45)48-19-22-5-2-1-3-6-22)23-9-11-24(12-10-23)32(33(38,39)40,34(41,42)43)49-20-27-28(36)7-4-8-29(27)37/h1-16H,17-21H2 ZLPNRGZKPUGTND-UHFFFAOYSA-N 253051 US9458171, 7 Nuclear receptor ROR-gamma [262-507] 103 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253051 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253051&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118207831 346547419 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440549 Fc1ccc(cc1)S(=O)(=O)C1(CCNC1)c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F InChI=1S/C26H20F9NO3S/c27-18-8-10-19(11-9-18)40(37,38)23(12-13-36-15-23)16-4-6-17(7-5-16)24(25(30,31)32,26(33,34)35)39-14-20-21(28)2-1-3-22(20)29/h1-11,36H,12-15H2 MEHSHYGABGFKAG-UHFFFAOYSA-N 253052 US9458171, 8 Nuclear receptor ROR-gamma [262-507] 47 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253052 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253052&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118207981 346547420 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440550 Fc1ccc(cc1)S(=O)(=O)[C@]1(CCNC1)c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F InChI=1S/C26H20F9NO3S/c27-18-8-10-19(11-9-18)40(37,38)23(12-13-36-15-23)16-4-6-17(7-5-16)24(25(30,31)32,26(33,34)35)39-14-20-21(28)2-1-3-22(20)29/h1-11,36H,12-15H2/t23-/m0/s1 MEHSHYGABGFKAG-QHCPKHFHSA-N 253610 US9458171, 9 Nuclear receptor ROR-gamma [262-507] 48 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253610 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253610&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118207978 346547974 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440551 Fc1ccc(cc1)S(=O)(=O)[C@@]1(CCNC1)c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F InChI=1S/C26H20F9NO3S/c27-18-8-10-19(11-9-18)40(37,38)23(12-13-36-15-23)16-4-6-17(7-5-16)24(25(30,31)32,26(33,34)35)39-14-20-21(28)2-1-3-22(20)29/h1-11,36H,12-15H2/t23-/m1/s1 MEHSHYGABGFKAG-HSZRJFAPSA-N 253053 US9458171, 10 Nuclear receptor ROR-gamma [262-507] 59 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253053 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253053&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118208090 346547421 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440552 CC(=O)N1CCC(CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C27H27F7N2O5S/c1-17(37)35-13-10-18(11-14-35)23(38)36-15-12-24(16-36,42(40,41)22-8-6-21(28)7-9-22)19-2-4-20(5-3-19)25(39,26(29,30)31)27(32,33)34/h2-9,18,39H,10-16H2,1H3/t24-/m0/s1 KJQFBTHRWLTPCF-DEOSSOPVSA-N 253054 US9458171, 11 Nuclear receptor ROR-gamma [262-507] 142 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253054 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253054&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118208112 346547422 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440553 CC(=O)N1CCN(CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C26H26F7N3O5S/c1-17(37)34-12-14-35(15-13-34)22(38)36-11-10-23(16-36,42(40,41)21-8-6-20(27)7-9-21)18-2-4-19(5-3-18)24(39,25(28,29)30)26(31,32)33/h2-9,39H,10-16H2,1H3/t23-/m0/s1 LGFLFKROQCMBLV-QHCPKHFHSA-N 253055 US9458171, 12 Nuclear receptor ROR-gamma [262-507] 44 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253055 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253055&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search L8A 6O98 118207970 346547423 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440554 CCOC(=O)C1CCN(CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H29F7N2O6S/c1-2-43-23(38)18-11-14-36(15-12-18)24(39)37-16-13-25(17-37,44(41,42)22-9-7-21(29)8-10-22)19-3-5-20(6-4-19)26(40,27(30,31)32)28(33,34)35/h3-10,18,40H,2,11-17H2,1H3/t25-/m0/s1 XUSOIHPFJMNNIU-VWLOTQADSA-N 253056 US9458171, 13 Nuclear receptor ROR-gamma [262-507] 289 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253056 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253056&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217539 346547424 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440555 OC(=O)C1CCN(CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C26H25F7N2O6S/c27-19-5-7-20(8-6-19)42(40,41)23(11-14-35(15-23)22(38)34-12-9-16(10-13-34)21(36)37)17-1-3-18(4-2-17)24(39,25(28,29)30)26(31,32)33/h1-8,16,39H,9-15H2,(H,36,37)/t23-/m0/s1 TYQLYJDUYBCMDK-QHCPKHFHSA-N 253057 US9458171, 14 Nuclear receptor ROR-gamma [262-507] 149 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253057 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253057&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118207920 346547425 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440556 COC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H28F7NO6S/c1-42-24(38)18-4-2-17(3-5-18)23(37)36-15-14-25(16-36,43(40,41)22-12-10-21(29)11-13-22)19-6-8-20(9-7-19)26(39,27(30,31)32)28(33,34)35/h6-13,17-18,39H,2-5,14-16H2,1H3/t17-,18-,25-/m0/s1 UPVOFJMQEIBORD-RPPIVITFSA-N 253058 US9458171, 15 Nuclear receptor ROR-gamma [262-507] 129 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253058 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253058&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118207972 346547426 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440557 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C27H26F7NO6S/c28-20-9-11-21(12-10-20)42(40,41)24(13-14-35(15-24)22(36)16-1-3-17(4-2-16)23(37)38)18-5-7-19(8-6-18)25(39,26(29,30)31)27(32,33)34/h5-12,16-17,39H,1-4,13-15H2,(H,37,38)/t16-,17-,24-/m0/s1 JROYPKLSTOFQSI-UAVUOLJFSA-N 253059 US9458171, 16 Nuclear receptor ROR-gamma [262-507] 79 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253059 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253059&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118207854 346547427 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440558 Fc1ccc(cc1)S(=O)(=O)C1(CCN(C1)c1ncc(cn1)C#N)c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F InChI=1S/C31H21F9N4O3S/c32-22-8-10-23(11-9-22)48(45,46)28(12-13-44(18-28)27-42-15-19(14-41)16-43-27)20-4-6-21(7-5-20)29(30(35,36)37,31(38,39)40)47-17-24-25(33)2-1-3-26(24)34/h1-11,15-16H,12-13,17-18H2 BGIMWUINTMBXKQ-UHFFFAOYSA-N 253060 US9458171, 17 Nuclear receptor ROR-gamma [262-507] 74 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253060 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253060&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118207967 346547428 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440559 CC(C)(C)OC(=O)CN1CCC(C1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C32H30F9NO5S/c1-28(2,3)47-27(43)17-42-16-15-29(19-42,48(44,45)23-13-11-22(33)12-14-23)20-7-9-21(10-8-20)30(31(36,37)38,32(39,40)41)46-18-24-25(34)5-4-6-26(24)35/h4-14H,15-19H2,1-3H3 CXWDAQMKVNIWHJ-UHFFFAOYSA-N 253061 US9458171, 18 Nuclear receptor ROR-gamma [262-507] 129 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253061 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253061&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118208081 346547429 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440560 Fc1ccc(cc1)S(=O)(=O)C1(CCN(CC(=O)N2CCOCC2)C1)c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F InChI=1S/C32H29F9N2O5S/c33-23-8-10-24(11-9-23)49(45,46)29(12-13-42(20-29)18-28(44)43-14-16-47-17-15-43)21-4-6-22(7-5-21)30(31(36,37)38,32(39,40)41)48-19-25-26(34)2-1-3-27(25)35/h1-11H,12-20H2 TUKLILPFNBVPTG-UHFFFAOYSA-N 253062 US9458171, 19 Nuclear receptor ROR-gamma [262-507] 58 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253062 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253062&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118207814 346547430 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440561 OC(=O)C1(CCN(CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1)C(F)(F)F InChI=1S/C34H28F12N2O6S/c35-22-8-10-23(11-9-22)55(52,53)30(14-17-48(19-30)28(51)47-15-12-29(13-16-47,27(49)50)32(38,39)40)20-4-6-21(7-5-20)31(33(41,42)43,34(44,45)46)54-18-24-25(36)2-1-3-26(24)37/h1-11H,12-19H2,(H,49,50)/t30-/m0/s1 JBNYWYXPKQRUGY-PMERELPUSA-N 253063 US9458171, 20 Nuclear receptor ROR-gamma [262-507] 68 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253063 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253063&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217541 346547431 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440562 OC(=O)C1CCN(CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(OCC1CCCCC1)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C33H37F7N2O6S/c34-26-10-12-27(13-11-26)49(46,47)30(16-19-42(21-30)29(45)41-17-14-23(15-18-41)28(43)44)24-6-8-25(9-7-24)31(32(35,36)37,33(38,39)40)48-20-22-4-2-1-3-5-22/h6-13,22-23H,1-5,14-21H2,(H,43,44)/t30-/m0/s1 XIDLZHMCHLHWAD-PMERELPUSA-N 253064 US9458171, 21 Nuclear receptor ROR-gamma [262-507] 149 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253064 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253064&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118208195 346547432 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440563 CC(=O)N1CCC(CC1)(C#N)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C35H30F9N3O5S/c1-22(48)46-16-13-31(20-45,14-17-46)30(49)47-18-15-32(21-47,53(50,51)26-11-9-25(36)10-12-26)23-5-7-24(8-6-23)33(34(39,40)41,35(42,43)44)52-19-27-28(37)3-2-4-29(27)38/h2-12H,13-19,21H2,1H3/t32-/m0/s1 LDQFBHYTJKOTGC-YTTGMZPUSA-N 253065 US9458171, 22 Nuclear receptor ROR-gamma [262-507] 106 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253065 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253065&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118207848 346547433 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440564 CC(=O)N1CCC(CC1)(C(N)=O)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C35H32F9N3O6S/c1-21(48)46-16-13-31(14-17-46,29(45)49)30(50)47-18-15-32(20-47,54(51,52)25-11-9-24(36)10-12-25)22-5-7-23(8-6-22)33(34(39,40)41,35(42,43)44)53-19-26-27(37)3-2-4-28(26)38/h2-12H,13-20H2,1H3,(H2,45,49)/t32-/m0/s1 UXYUTHZFDWWDSC-YTTGMZPUSA-N 253066 US9458171, 23 Nuclear receptor ROR-gamma [262-507] 71 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253066 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253066&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118207815 346547434 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440565 CC(=O)N1CCC(O)(CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C34H31F9N2O6S/c1-21(46)44-16-13-30(48,14-17-44)29(47)45-18-15-31(20-45,52(49,50)25-11-9-24(35)10-12-25)22-5-7-23(8-6-22)32(33(38,39)40,34(41,42)43)51-19-26-27(36)3-2-4-28(26)37/h2-12,48H,13-20H2,1H3/t31-/m0/s1 PIPPDPCSZQXYFH-HKBQPEDESA-N 253067 US9458171, 24 Nuclear receptor ROR-gamma [262-507] 50 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253067 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253067&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118208124 346547435 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440566 CC(=O)N1CCC(CO)(CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C35H33F9N2O6S/c1-22(48)45-16-13-31(21-47,14-17-45)30(49)46-18-15-32(20-46,53(50,51)26-11-9-25(36)10-12-26)23-5-7-24(8-6-23)33(34(39,40)41,35(42,43)44)52-19-27-28(37)3-2-4-29(27)38/h2-12,47H,13-21H2,1H3/t32-/m0/s1 NTRAURVVZSHWCD-YTTGMZPUSA-N 253068 US9458171, 25 Nuclear receptor ROR-gamma [262-507] 31 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253068 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253068&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118208027 346547436 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440567 OCC1(CCOCC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C33H30F9NO6S/c34-23-8-10-24(11-9-23)50(46,47)30(12-15-43(19-30)28(45)29(20-44)13-16-48-17-14-29)21-4-6-22(7-5-21)31(32(37,38)39,33(40,41)42)49-18-25-26(35)2-1-3-27(25)36/h1-11,44H,12-20H2/t30-/m0/s1 NAVRHZGJCXSYRL-PMERELPUSA-N 253069 US9458171, 26 Nuclear receptor ROR-gamma [262-507] 114 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253069 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253069&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118207900 346547437 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440568 CC(=O)N1CCC(CC1)C(=O)N1CC[C@@](C1)(c1ccc(cc1)C(OCc1c(F)cccc1C(O)=O)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C35H32F8N2O7S/c1-21(46)44-16-13-22(14-17-44)30(47)45-18-15-32(20-45,53(50,51)26-11-9-25(36)10-12-26)23-5-7-24(8-6-23)33(34(38,39)40,35(41,42)43)52-19-28-27(31(48)49)3-2-4-29(28)37/h2-12,22H,13-20H2,1H3,(H,48,49)/t32-/m1/s1 BIGPPDHLJDLEIY-JGCGQSQUSA-N 253611 US9458171, 27 Nuclear receptor ROR-gamma [262-507] 951 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253611 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253611&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 131636487 346547975 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440569 COc1ccc(cc1)S(=O)(=O)[C@]1(CCN(C1)C(=O)C1CCN(CC1)C(C)=O)c1ccc(cc1)C(OCc1c(F)cccc1C(O)=O)(C(F)(F)F)C(F)(F)F InChI=1S/C36H35F7N2O8S/c1-22(46)44-17-14-23(15-18-44)31(47)45-19-16-33(21-45,54(50,51)27-12-10-26(52-2)11-13-27)24-6-8-25(9-7-24)34(35(38,39)40,36(41,42)43)53-20-29-28(32(48)49)4-3-5-30(29)37/h3-13,23H,14-21H2,1-2H3,(H,48,49)/t33-/m0/s1 WAZDSSQPKVWOOY-XIFFEERXSA-N 253070 US9458171, 28 Nuclear receptor ROR-gamma [262-507] 1876 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253070 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253070&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118208096 346547438 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440570 Nc1ccc(cc1)S(=O)(=O)[C@]1(CCN(C1)C(=O)N1CCC(CC1)C#N)c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F InChI=1S/C33H30F8N4O4S/c34-27-2-1-3-28(35)26(27)19-49-31(32(36,37)38,33(39,40)41)23-6-4-22(5-7-23)30(50(47,48)25-10-8-24(43)9-11-25)14-17-45(20-30)29(46)44-15-12-21(18-42)13-16-44/h1-11,21H,12-17,19-20,43H2/t30-/m0/s1 UBSLGSPNQVXHNV-PMERELPUSA-N 253612 US9458171, 29 Nuclear receptor ROR-gamma [262-507] 217 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253612 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253612&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118208039 346547976 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440571 Fc1cccc(F)c1COC(c1ccc(cc1)[C@@]1(CCN(C1)C(=O)N1CCC(CC1)C#N)S(=O)(=O)c1ccc(cc1)N=[N+]=[N-])(C(F)(F)F)C(F)(F)F InChI=1S/C33H28F8N6O4S/c34-27-2-1-3-28(35)26(27)19-51-31(32(36,37)38,33(39,40)41)23-6-4-22(5-7-23)30(52(49,50)25-10-8-24(9-11-25)44-45-43)14-17-47(20-30)29(48)46-15-12-21(18-42)13-16-46/h1-11,21H,12-17,19-20H2/t30-/m0/s1 QJYGJSGLKQCZQL-PMERELPUSA-N 253071 US9458171, 30 Nuclear receptor ROR-gamma [262-507] 31 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253071 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253071&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217542 346547439 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440572 OC(=O)C1CCN(CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(cc1)C#N InChI=1S/C34H29F8N3O6S/c35-27-2-1-3-28(36)26(27)19-51-32(33(37,38)39,34(40,41)42)24-8-6-23(7-9-24)31(52(49,50)25-10-4-21(18-43)5-11-25)14-17-45(20-31)30(48)44-15-12-22(13-16-44)29(46)47/h1-11,22H,12-17,19-20H2,(H,46,47)/t31-/m0/s1 FFQKENLXBBYOKH-HKBQPEDESA-N 253072 US9458171, 31 Nuclear receptor ROR-gamma [262-507] 120 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253072 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253072&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118208142 346547440 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440573 CC(=O)N1CCN(CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(Oc2ccccc2)cc1 InChI=1S/C32H31F6N3O6S/c1-22(42)39-17-19-40(20-18-39)28(43)41-16-15-29(21-41,23-7-9-24(10-8-23)30(44,31(33,34)35)32(36,37)38)48(45,46)27-13-11-26(12-14-27)47-25-5-3-2-4-6-25/h2-14,44H,15-21H2,1H3/t29-/m0/s1 HBRPBBHZGSAVSF-LJAQVGFWSA-N 253073 US9458171, 32 Nuclear receptor ROR-gamma [262-507] 2156 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253073 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253073&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118208061 346547441 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440574 OC(=O)C1CCN(CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(Oc2ccccc2)cc1 InChI=1S/C39H34F8N2O7S/c40-32-7-4-8-33(41)31(32)23-55-37(38(42,43)44,39(45,46)47)27-11-9-26(10-12-27)36(19-22-49(24-36)35(52)48-20-17-25(18-21-48)34(50)51)57(53,54)30-15-13-29(14-16-30)56-28-5-2-1-3-6-28/h1-16,25H,17-24H2,(H,50,51)/t36-/m0/s1 MGMGYVYMOUANGK-BHVANESWSA-N 253074 US9458171, 33 Nuclear receptor ROR-gamma [262-507] 503 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253074 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253074&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118207867 346547442 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440575 NC(=O)CN1CC[C@](C1)(c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C21H18F8N2O3S/c22-15-5-7-16(8-6-15)35(33,34)18(9-10-31(12-18)11-17(30)32)13-1-3-14(4-2-13)19(23,20(24,25)26)21(27,28)29/h1-8H,9-12H2,(H2,30,32)/t18-/m0/s1 MMPVCNUDICQKKA-SFHVURJKSA-N 253075 US9458171, 34 Nuclear receptor ROR-gamma [262-507] 21 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253075 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253075&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118207836 346547443 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440576 CC(=O)N1CCC(CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(Oc1ccccc1)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C33H31F7N2O5S/c1-22(43)41-18-15-23(16-19-41)29(44)42-20-17-30(21-42,48(45,46)28-13-11-26(34)12-14-28)24-7-9-25(10-8-24)31(32(35,36)37,33(38,39)40)47-27-5-3-2-4-6-27/h2-14,23H,15-21H2,1H3/t30-/m0/s1 YOEBSRILIHKIJO-PMERELPUSA-N 253076 US9458171, 35 Nuclear receptor ROR-gamma [262-507] 227 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253076 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253076&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118208066 346547444 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440577 CCc1cc(ccc1F)S(=O)(=O)C1(CCN(C1)C(=O)N1CCN(CC1)C(C)=O)c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F InChI=1S/C35H34F9N3O5S/c1-3-23-19-26(11-12-28(23)36)53(50,51)32(13-14-47(21-32)31(49)46-17-15-45(16-18-46)22(2)48)24-7-9-25(10-8-24)33(34(39,40)41,35(42,43)44)52-20-27-29(37)5-4-6-30(27)38/h4-12,19H,3,13-18,20-21H2,1-2H3 RNGSWGDIBRBGHJ-UHFFFAOYSA-N 253077 US9458171, 36 Nuclear receptor ROR-gamma [262-507] 213 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253077 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253077&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118208176 346547445 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440578 Fc1ccc(cc1)S(=O)(=O)[C@@]1(CCN(C1)C(=O)OCc1ccccc1)c1ccc(I)cc1 InChI=1S/C24H21FINO4S/c25-20-8-12-22(13-9-20)32(29,30)24(19-6-10-21(26)11-7-19)14-15-27(17-24)23(28)31-16-18-4-2-1-3-5-18/h1-13H,14-17H2/t24-/m1/s1 DSMRPYCWSIKLNO-XMMPIXPASA-N 253078 US9458171, 37 Nuclear receptor ROR-gamma [262-507] 360 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253078 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253078&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217543 346547446 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440579 Fc1ccc(cc1)S(=O)(=O)[C@]1(CCN(C1)C(=O)OCc1ccccc1)c1ccc(I)cc1 InChI=1S/C24H21FINO4S/c25-20-8-12-22(13-9-20)32(29,30)24(19-6-10-21(26)11-7-19)14-15-27(17-24)23(28)31-16-18-4-2-1-3-5-18/h1-13H,14-17H2/t24-/m0/s1 DSMRPYCWSIKLNO-DEOSSOPVSA-N 253613 US9458171, 38 Nuclear receptor ROR-gamma [262-507] 4991 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253613 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253613&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217544 346547977 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440580 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)-c1c(F)cccc1F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C30H28F3NO5S/c31-23-12-14-24(15-13-23)40(38,39)30(22-10-8-19(9-11-22)27-25(32)2-1-3-26(27)33)16-17-34(18-30)28(35)20-4-6-21(7-5-20)29(36)37/h1-3,8-15,20-21H,4-7,16-18H2,(H,36,37)/t20-,21-,30-/m0/s1 NZDHORBXJJHDJW-LPBFERMMSA-N 253079 US9458171, 39 Nuclear receptor ROR-gamma [262-507] 72 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253079 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253079&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118207946 346547447 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440581 CC(=O)N1CCN(CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(O)(c1ccccc1)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C31H31F4N3O5S/c1-22(39)36-17-19-37(20-18-36)28(40)38-16-15-29(21-38,44(42,43)27-13-11-26(32)12-14-27)23-7-9-25(10-8-23)30(41,31(33,34)35)24-5-3-2-4-6-24/h2-14,41H,15-21H2,1H3/t29-,30?/m0/s1 LZAFEAFNWHEHRF-UFXYQILXSA-N 253080 US9458171, 40 Nuclear receptor ROR-gamma [262-507] 50 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253080 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253080&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118207899 346547448 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440582 COC(c1ccccc1)(c1ccc(cc1)[C@@]1(CCN(C1)C(=O)N1CCN(CC1)C(C)=O)S(=O)(=O)c1ccc(F)cc1)C(F)(F)F InChI=1S/C32H33F4N3O5S/c1-23(40)37-18-20-38(21-19-37)29(41)39-17-16-30(22-39,45(42,43)28-14-12-27(33)13-15-28)24-8-10-26(11-9-24)31(44-2,32(34,35)36)25-6-4-3-5-7-25/h3-15H,16-22H2,1-2H3/t30-,31?/m0/s1 IKIYWVVFNPNCQS-FSRLHOSWSA-N 253081 US9458171, 41 Nuclear receptor ROR-gamma [262-507] 46 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253081 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253081&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118208053 346547449 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440583 CC(=O)N1CCN(CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(F)(c1ccccc1)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C31H30F5N3O4S/c1-22(40)37-17-19-38(20-18-37)28(41)39-16-15-29(21-39,44(42,43)27-13-11-26(32)12-14-27)23-7-9-25(10-8-23)30(33,31(34,35)36)24-5-3-2-4-6-24/h2-14H,15-21H2,1H3/t29-,30?/m0/s1 MPHCPRIXWYWOMY-UFXYQILXSA-N 253082 US9458171, 42 Nuclear receptor ROR-gamma [262-507] 49 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253082 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253082&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118207958 346547450 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440584 OC(c1ccc(cc1)C1(CCNC1)S(=O)(=O)c1ccccc1)(C(F)(F)F)C(F)(F)F InChI=1S/C19H17F6NO3S/c20-18(21,22)17(27,19(23,24)25)14-8-6-13(7-9-14)16(10-11-26-12-16)30(28,29)15-4-2-1-3-5-15/h1-9,26-27H,10-12H2 PMVJEHRECLYKSJ-UHFFFAOYSA-N 253083 US9458171, 43 Nuclear receptor ROR-gamma [262-507] 945 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253083 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253083&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217531 346547451 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440585 CC(C)(C)CN1CCC(C1)(c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccccc1 InChI=1S/C24H27F6NO3S/c1-20(2,3)15-31-14-13-21(16-31,35(33,34)19-7-5-4-6-8-19)17-9-11-18(12-10-17)22(32,23(25,26)27)24(28,29)30/h4-12,32H,13-16H2,1-3H3 ORAZGAHFKZTRFW-UHFFFAOYSA-N 253084 US9458171, 44 Nuclear receptor ROR-gamma [262-507] 460 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253084 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253084&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217545 346547452 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440586 OC(c1ccc(cc1)C1(CCN(Cc2ccccc2)C1)S(=O)(=O)c1ccccc1)(C(F)(F)F)C(F)(F)F InChI=1S/C26H23F6NO3S/c27-25(28,29)24(34,26(30,31)32)21-13-11-20(12-14-21)23(37(35,36)22-9-5-2-6-10-22)15-16-33(18-23)17-19-7-3-1-4-8-19/h1-14,34H,15-18H2 XOFSSRYMCRTICF-UHFFFAOYSA-N 253085 US9458171, 45 Nuclear receptor ROR-gamma [262-507] 1222 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253085 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253085&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217528 346547453 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440587 OC(c1ccc(cc1)C1(CCN(C1)c1ncc(cn1)C#N)S(=O)(=O)c1ccccc1)(C(F)(F)F)C(F)(F)F InChI=1S/C24H18F6N4O3S/c25-23(26,27)22(35,24(28,29)30)18-8-6-17(7-9-18)21(38(36,37)19-4-2-1-3-5-19)10-11-34(15-21)20-32-13-16(12-31)14-33-20/h1-9,13-14,35H,10-11,15H2 FEKIGBFHMYMHDO-UHFFFAOYSA-N 253086 US9458171, 46 Nuclear receptor ROR-gamma [262-507] 925 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253086 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253086&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217546 346547454 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440588 CC(=O)N1CCC(C1)(c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccccc1 InChI=1S/C21H19F6NO4S/c1-14(29)28-12-11-18(13-28,33(31,32)17-5-3-2-4-6-17)15-7-9-16(10-8-15)19(30,20(22,23)24)21(25,26)27/h2-10,30H,11-13H2,1H3 AODCTBKQHAHMGG-UHFFFAOYSA-N 253087 US9458171, 47 Nuclear receptor ROR-gamma [262-507] 2931 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253087 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253087&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217549 346547455 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440589 CC(=O)N1CCC(C1)(c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C21H18F7NO4S/c1-13(30)29-11-10-18(12-29,34(32,33)17-8-6-16(22)7-9-17)14-2-4-15(5-3-14)19(31,20(23,24)25)21(26,27)28/h2-9,31H,10-12H2,1H3 WSIFDSOTEVLMPK-UHFFFAOYSA-N 253088 US9458171, 48 Nuclear receptor ROR-gamma [262-507] 317 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253088 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253088&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217550 346547456 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440590 COCC(=O)N1CCC(C1)(c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C22H20F7NO5S/c1-35-12-18(31)30-11-10-19(13-30,36(33,34)17-8-6-16(23)7-9-17)14-2-4-15(5-3-14)20(32,21(24,25)26)22(27,28)29/h2-9,32H,10-13H2,1H3 LCCYGMULGJHCLN-UHFFFAOYSA-N 253089 US9458171, 49 Nuclear receptor ROR-gamma [262-507] 281 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253089 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253089&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217547 346547457 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440591 OC(c1ccc(cc1)C1(CCN(C1)C(=O)C1CCCC1)S(=O)(=O)c1ccc(F)cc1)(C(F)(F)F)C(F)(F)F InChI=1S/C25H24F7NO4S/c26-19-9-11-20(12-10-19)38(36,37)22(13-14-33(15-22)21(34)16-3-1-2-4-16)17-5-7-18(8-6-17)23(35,24(27,28)29)25(30,31)32/h5-12,16,35H,1-4,13-15H2 AWOZLZVEQAYRHZ-UHFFFAOYSA-N 253090 US9458171, 50 Nuclear receptor ROR-gamma [262-507] 114 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253090 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253090&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217548 346547458 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440592 CC(C)(C)CC(=O)N1CCC(C1)(c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccccc1 InChI=1S/C25H27F6NO4S/c1-21(2,3)15-20(33)32-14-13-22(16-32,37(35,36)19-7-5-4-6-8-19)17-9-11-18(12-10-17)23(34,24(26,27)28)25(29,30)31/h4-12,34H,13-16H2,1-3H3 YNONMLRXLFOLAA-UHFFFAOYSA-N 253091 US9458171, 51 Nuclear receptor ROR-gamma [262-507] 234 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253091 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253091&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217551 346547459 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440593 OC(c1ccc(cc1)[C@@]1(CCN(C1)C(=O)C1CCN(CC1)C=O)S(=O)(=O)c1ccc(F)cc1)(C(F)(F)F)C(F)(F)F InChI=1S/C26H25F7N2O5S/c27-20-5-7-21(8-6-20)41(39,40)23(11-14-35(15-23)22(37)17-9-12-34(16-36)13-10-17)18-1-3-19(4-2-18)24(38,25(28,29)30)26(31,32)33/h1-8,16-17,38H,9-15H2/t23-/m0/s1 HMVDHFAWDBUQNB-QHCPKHFHSA-N 253092 US9458171, 52 Nuclear receptor ROR-gamma [262-507] 96 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253092 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253092&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217552 346547460 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440594 CC(=O)N1CCC(CC1)C(=O)N1CCC(C1)(c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C27H27F7N2O5S/c1-17(37)35-13-10-18(11-14-35)23(38)36-15-12-24(16-36,42(40,41)22-8-6-21(28)7-9-22)19-2-4-20(5-3-19)25(39,26(29,30)31)27(32,33)34/h2-9,18,39H,10-16H2,1H3 KJQFBTHRWLTPCF-UHFFFAOYSA-N 253093 US9458171, 53 Nuclear receptor ROR-gamma [262-507] 27 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253093 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253093&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118208114 346547461 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440595 CC(=O)N1CCC(CC1)C(=O)N1CC[C@@](C1)(c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C27H27F7N2O5S/c1-17(37)35-13-10-18(11-14-35)23(38)36-15-12-24(16-36,42(40,41)22-8-6-21(28)7-9-22)19-2-4-20(5-3-19)25(39,26(29,30)31)27(32,33)34/h2-9,18,39H,10-16H2,1H3/t24-/m1/s1 KJQFBTHRWLTPCF-XMMPIXPASA-N 253094 US9458171, 54 Nuclear receptor ROR-gamma [262-507] 1702 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253094 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253094&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217553 346547462 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440596 NC(=O)N1CCC(CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C26H26F7N3O5S/c27-19-5-7-20(8-6-19)42(40,41)23(11-14-36(15-23)21(37)16-9-12-35(13-10-16)22(34)38)17-1-3-18(4-2-17)24(39,25(28,29)30)26(31,32)33/h1-8,16,39H,9-15H2,(H2,34,38)/t23-/m0/s1 OGKPJOWUQAZRMI-QHCPKHFHSA-N 253095 US9458171, 55 Nuclear receptor ROR-gamma [262-507] 46 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253095 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253095&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217554 346547463 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440597 CS(=O)(=O)N1CCC(CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C26H27F7N2O6S2/c1-42(38,39)35-13-10-17(11-14-35)22(36)34-15-12-23(16-34,43(40,41)21-8-6-20(27)7-9-21)18-2-4-19(5-3-18)24(37,25(28,29)30)26(31,32)33/h2-9,17,37H,10-16H2,1H3/t23-/m0/s1 QVPVWDKIJLWWPO-QHCPKHFHSA-N 253096 US9458171, 56 Nuclear receptor ROR-gamma [262-507] 52 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253096 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253096&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217555 346547464 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440598 CC(=O)N1CCC(CC1)(C(N)=O)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H28F7N3O6S/c1-17(39)37-13-10-24(11-14-37,22(36)40)23(41)38-15-12-25(16-38,45(43,44)21-8-6-20(29)7-9-21)18-2-4-19(5-3-18)26(42,27(30,31)32)28(33,34)35/h2-9,42H,10-16H2,1H3,(H2,36,40)/t25-/m0/s1 HFLZPPATCDUYOD-VWLOTQADSA-N 253097 US9458171, 57 Nuclear receptor ROR-gamma [262-507] 85 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253097 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253097&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217556 346547465 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440599 OCC1(CCOCC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C26H26F7NO6S/c27-19-5-7-20(8-6-19)41(38,39)23(9-12-34(15-23)21(36)22(16-35)10-13-40-14-11-22)17-1-3-18(4-2-17)24(37,25(28,29)30)26(31,32)33/h1-8,35,37H,9-16H2/t23-/m0/s1 YWOZVEVSXXBXMG-QHCPKHFHSA-N 253098 US9458171, 58 Nuclear receptor ROR-gamma [262-507] 91 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253098 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253098&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217557 346547466 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440600 OC(c1ccc(cc1)C1(CCN(C1)C(=O)c1ccccc1)S(=O)(=O)c1ccccc1)(C(F)(F)F)C(F)(F)F InChI=1S/C26H21F6NO4S/c27-25(28,29)24(35,26(30,31)32)20-13-11-19(12-14-20)23(38(36,37)21-9-5-2-6-10-21)15-16-33(17-23)22(34)18-7-3-1-4-8-18/h1-14,35H,15-17H2 HUXJUHSBZUIEER-UHFFFAOYSA-N 253099 US9458171, 59 Nuclear receptor ROR-gamma [262-507] 3904 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253099 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253099&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217558 346547467 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440601 CCS(=O)(=O)c1ccc(CC(=O)N2CC[C@](C2)(c2ccc(cc2)C(O)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c2ccc(F)cc2)cc1 InChI=1S/C29H26F7NO6S2/c1-2-44(40,41)23-11-3-19(4-12-23)17-25(38)37-16-15-26(18-37,45(42,43)24-13-9-22(30)10-14-24)20-5-7-21(8-6-20)27(39,28(31,32)33)29(34,35)36/h3-14,39H,2,15-18H2,1H3/t26-/m0/s1 HBLZOAIIYAZHDL-SANMLTNESA-N 253100 US9458171, 60 Nuclear receptor ROR-gamma [262-507] 485 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253100 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253100&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217560 346547468 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440602 OC(c1ccc(cc1)[C@@]1(CCN(C1)C(=O)Cc1ccncc1)S(=O)(=O)c1ccc(F)cc1)(C(F)(F)F)C(F)(F)F InChI=1S/C26H21F7N2O4S/c27-20-5-7-21(8-6-20)40(38,39)23(11-14-35(16-23)22(36)15-17-9-12-34-13-10-17)18-1-3-19(4-2-18)24(37,25(28,29)30)26(31,32)33/h1-10,12-13,37H,11,14-16H2/t23-/m0/s1 QNELSWWQVPXWQP-QHCPKHFHSA-N 253101 US9458171, 61 Nuclear receptor ROR-gamma [262-507] 54 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253101 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253101&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217559 346547469 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440603 COC(=O)N1CCC(C1)(c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C21H18F7NO5S/c1-34-17(30)29-11-10-18(12-29,35(32,33)16-8-6-15(22)7-9-16)13-2-4-14(5-3-13)19(31,20(23,24)25)21(26,27)28/h2-9,31H,10-12H2,1H3 OJBNWWGQLDOQLL-UHFFFAOYSA-N 253102 US9458171, 62 Nuclear receptor ROR-gamma [262-507] 169 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253102 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253102&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217561 346547470 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440604 CCOC(=O)N1CCC(C1)(c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C22H20F7NO5S/c1-2-35-18(31)30-12-11-19(13-30,36(33,34)17-9-7-16(23)8-10-17)14-3-5-15(6-4-14)20(32,21(24,25)26)22(27,28)29/h3-10,32H,2,11-13H2,1H3 INNSRAOKNFESFK-UHFFFAOYSA-N 253103 US9458171, 63 Nuclear receptor ROR-gamma [262-507] 204 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253103 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253103&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217563 346547471 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440605 OC(c1ccc(cc1)C1(CCN(C1)C(=O)OCCF)S(=O)(=O)c1ccccc1)(C(F)(F)F)C(F)(F)F InChI=1S/C22H20F7NO5S/c23-11-13-35-18(31)30-12-10-19(14-30,36(33,34)17-4-2-1-3-5-17)15-6-8-16(9-7-15)20(32,21(24,25)26)22(27,28)29/h1-9,32H,10-14H2 HNCJWRPINNWOPV-UHFFFAOYSA-N 253104 US9458171, 64 Nuclear receptor ROR-gamma [262-507] 615 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253104 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253104&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217562 346547472 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440606 CC(C)OC(=O)N1CCC(C1)(c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C23H22F7NO5S/c1-14(2)36-19(32)31-12-11-20(13-31,37(34,35)18-9-7-17(24)8-10-18)15-3-5-16(6-4-15)21(33,22(25,26)27)23(28,29)30/h3-10,14,33H,11-13H2,1-2H3 CFWACQGPWVBDMP-UHFFFAOYSA-N 253105 US9458171, 65 Nuclear receptor ROR-gamma [262-507] 381 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253105 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253105&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217564 346547473 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440607 CC(C)(C)OC(=O)N1CCC(C1)(c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccccc1 InChI=1S/C24H25F6NO5S/c1-20(2,3)36-19(32)31-14-13-21(15-31,37(34,35)18-7-5-4-6-8-18)16-9-11-17(12-10-16)22(33,23(25,26)27)24(28,29)30/h4-12,33H,13-15H2,1-3H3 LFFOYLGZNHQIHF-UHFFFAOYSA-N 253106 US9458171, 66 Nuclear receptor ROR-gamma [262-507] 148 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253106 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253106&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217565 346547474 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440608 CC(C)(C)OC(=O)N1CCC(C1)(c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C24H24F7NO5S/c1-20(2,3)37-19(33)32-13-12-21(14-32,38(35,36)18-10-8-17(25)9-11-18)15-4-6-16(7-5-15)22(34,23(26,27)28)24(29,30)31/h4-11,34H,12-14H2,1-3H3 RTUINZKXEHFGFD-UHFFFAOYSA-N 253107 US9458171, 67 Nuclear receptor ROR-gamma [262-507] 79 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253107 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253107&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118207975 346547475 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440609 CC(C)COC(=O)N1CCC(C1)(c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C24H24F7NO5S/c1-15(2)13-37-20(33)32-12-11-21(14-32,38(35,36)19-9-7-18(25)8-10-19)16-3-5-17(6-4-16)22(34,23(26,27)28)24(29,30)31/h3-10,15,34H,11-14H2,1-2H3 ZLMFNCFUEMXZAL-UHFFFAOYSA-N 253108 US9458171, 68 Nuclear receptor ROR-gamma [262-507] 151 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253108 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253108&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217566 346547476 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440610 OC(c1ccc(cc1)C1(CCN(C1)C(=O)OCc1ccccc1)S(=O)(=O)c1ccccc1)(C(F)(F)F)C(F)(F)F InChI=1S/C27H23F6NO5S/c28-26(29,30)25(36,27(31,32)33)21-13-11-20(12-14-21)24(40(37,38)22-9-5-2-6-10-22)15-16-34(18-24)23(35)39-17-19-7-3-1-4-8-19/h1-14,36H,15-18H2 GUXPUBOKKBNUQG-UHFFFAOYSA-N 253109 US9458171, 69 Nuclear receptor ROR-gamma [262-507] 1558 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253109 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253109&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217567 346547477 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440611 CCNC(=O)N1CCC(C1)(c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccccc1 InChI=1S/C22H22F6N2O4S/c1-2-29-18(31)30-13-12-19(14-30,35(33,34)17-6-4-3-5-7-17)15-8-10-16(11-9-15)20(32,21(23,24)25)22(26,27)28/h3-11,32H,2,12-14H2,1H3,(H,29,31) AHHKHTIJYBLTON-UHFFFAOYSA-N 253110 US9458171, 70 Nuclear receptor ROR-gamma [262-507] 674 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253110 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253110&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217568 346547478 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440612 CCNC(=O)N1CCC(C1)(c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C22H21F7N2O4S/c1-2-30-18(32)31-12-11-19(13-31,36(34,35)17-9-7-16(23)8-10-17)14-3-5-15(6-4-14)20(33,21(24,25)26)22(27,28)29/h3-10,33H,2,11-13H2,1H3,(H,30,32) MBZXEXLFJWPIQL-UHFFFAOYSA-N 253111 US9458171, 71 Nuclear receptor ROR-gamma [262-507] 249 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253111 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253111&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217576 346547479 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440613 CC(C)(C)NC(=O)N1CCC(C1)(c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccccc1 InChI=1S/C24H26F6N2O4S/c1-20(2,3)31-19(33)32-14-13-21(15-32,37(35,36)18-7-5-4-6-8-18)16-9-11-17(12-10-16)22(34,23(25,26)27)24(28,29)30/h4-12,34H,13-15H2,1-3H3,(H,31,33) GDIFKDCZRABZPT-UHFFFAOYSA-N 253112 US9458171, 72 Nuclear receptor ROR-gamma [262-507] 173 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253112 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253112&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217570 346547480 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440614 CC(C)(C)NC(=O)N1CCC(C1)(c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C24H25F7N2O4S/c1-20(2,3)32-19(34)33-13-12-21(14-33,38(36,37)18-10-8-17(25)9-11-18)15-4-6-16(7-5-15)22(35,23(26,27)28)24(29,30)31/h4-11,35H,12-14H2,1-3H3,(H,32,34) HBVIFEWCXFUUKQ-UHFFFAOYSA-N 253113 US9458171, 73 Nuclear receptor ROR-gamma [262-507] 125 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253113 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253113&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217572 346547481 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440615 OC(c1ccc(cc1)C1(CCN(C1)C(=O)NC1CCCCC1)S(=O)(=O)c1ccc(F)cc1)(C(F)(F)F)C(F)(F)F InChI=1S/C26H27F7N2O4S/c27-19-10-12-21(13-11-19)40(38,39)23(14-15-35(16-23)22(36)34-20-4-2-1-3-5-20)17-6-8-18(9-7-17)24(37,25(28,29)30)26(31,32)33/h6-13,20,37H,1-5,14-16H2,(H,34,36) AVOLLERALSLZJJ-UHFFFAOYSA-N 253114 US9458171, 74 Nuclear receptor ROR-gamma [262-507] 231 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253114 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253114&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217569 346547482 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440616 OC(c1ccc(cc1)C1(CCN(C1)C(=O)Nc1ccccc1)S(=O)(=O)c1ccc(F)cc1)(C(F)(F)F)C(F)(F)F InChI=1S/C26H21F7N2O4S/c27-19-10-12-21(13-11-19)40(38,39)23(14-15-35(16-23)22(36)34-20-4-2-1-3-5-20)17-6-8-18(9-7-17)24(37,25(28,29)30)26(31,32)33/h1-13,37H,14-16H2,(H,34,36) MIJBMLVRHRLTLU-UHFFFAOYSA-N 253115 US9458171, 75 Nuclear receptor ROR-gamma [262-507] 113 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253115 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253115&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217571 346547483 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440617 CC1(O)CCN(CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C26H27F7N2O5S/c1-22(37)10-13-34(14-11-22)21(36)35-15-12-23(16-35,41(39,40)20-8-6-19(27)7-9-20)17-2-4-18(5-3-17)24(38,25(28,29)30)26(31,32)33/h2-9,37-38H,10-16H2,1H3/t23-/m0/s1 OAPIYJURMLRZNB-QHCPKHFHSA-N 253116 US9458171, 76 Nuclear receptor ROR-gamma [262-507] 135 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253116 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253116&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217573 346547484 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440618 OC(c1ccc(cc1)[C@@]1(CCN(C1)C(=O)N1CCC(O)(CC1)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1)(C(F)(F)F)C(F)(F)F InChI=1S/C26H24F10N2O5S/c27-18-5-7-19(8-6-18)44(42,43)21(16-1-3-17(4-2-16)23(41,25(31,32)33)26(34,35)36)9-12-38(15-21)20(39)37-13-10-22(40,11-14-37)24(28,29)30/h1-8,40-41H,9-15H2/t21-/m0/s1 HCHRXHFDGULHTO-NRFANRHFSA-N 253117 US9458171, 77 Nuclear receptor ROR-gamma [262-507] 37 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253117 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253117&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217574 346547485 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440619 CN1CCN(CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C25H26F7N3O4S/c1-33-12-14-34(15-13-33)21(36)35-11-10-22(16-35,40(38,39)20-8-6-19(26)7-9-20)17-2-4-18(5-3-17)23(37,24(27,28)29)25(30,31)32/h2-9,37H,10-16H2,1H3/t22-/m0/s1 MIVPSADLEVZHRV-QFIPXVFZSA-N 253118 US9458171, 78 Nuclear receptor ROR-gamma [262-507] 141 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253118 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253118&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217575 346547486 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440620 CC(=O)N1CCN(CC1)C(=O)N1CC[C@@](C1)(c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C26H26F7N3O5S/c1-17(37)34-12-14-35(15-13-34)22(38)36-11-10-23(16-36,42(40,41)21-8-6-20(27)7-9-21)18-2-4-19(5-3-18)24(39,25(28,29)30)26(31,32)33/h2-9,39H,10-16H2,1H3/t23-/m1/s1 LGFLFKROQCMBLV-HSZRJFAPSA-N 253119 US9458171, 79 Nuclear receptor ROR-gamma [262-507] 166 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253119 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253119&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217580 346547487 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440621 OC(c1ccc(cc1)[C@@]1(CCN(C1)C(=O)N1CCN(CC1)C(=O)N1CCOCC1)S(=O)(=O)c1ccc(F)cc1)(C(F)(F)F)C(F)(F)F InChI=1S/C29H31F7N4O6S/c30-22-5-7-23(8-6-22)47(44,45)26(20-1-3-21(4-2-20)27(43,28(31,32)33)29(34,35)36)9-10-40(19-26)25(42)38-13-11-37(12-14-38)24(41)39-15-17-46-18-16-39/h1-8,43H,9-19H2/t26-/m0/s1 PIZJQYLQGYQXAK-SANMLTNESA-N 253120 US9458171, 80 Nuclear receptor ROR-gamma [262-507] 230 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253120 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253120&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217577 346547488 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440622 CS(=O)(=O)N1CCN(CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C25H26F7N3O6S2/c1-42(38,39)35-14-12-33(13-15-35)21(36)34-11-10-22(16-34,43(40,41)20-8-6-19(26)7-9-20)17-2-4-18(5-3-17)23(37,24(27,28)29)25(30,31)32/h2-9,37H,10-16H2,1H3/t22-/m0/s1 YGWVDFPHKKIUEF-QFIPXVFZSA-N 253121 US9458171, 81 Nuclear receptor ROR-gamma [262-507] 456 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253121 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253121&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217578 346547489 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440623 OC(c1ccc(cc1)C1(CCN(C1)C(=O)N1CCOCC1)S(=O)(=O)c1ccccc1)(C(F)(F)F)C(F)(F)F InChI=1S/C24H24F6N2O5S/c25-23(26,27)22(34,24(28,29)30)18-8-6-17(7-9-18)21(38(35,36)19-4-2-1-3-5-19)10-11-32(16-21)20(33)31-12-14-37-15-13-31/h1-9,34H,10-16H2 FNOICUPFDAFAKA-UHFFFAOYSA-N 253122 US9458171, 82 Nuclear receptor ROR-gamma [262-507] 245 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253122 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253122&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217579 346547490 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440624 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CC[C@@](C1)(c1ccc(cc1)-c1c(F)cccc1F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C30H28F3NO5S/c31-23-12-14-24(15-13-23)40(38,39)30(22-10-8-19(9-11-22)27-25(32)2-1-3-26(27)33)16-17-34(18-30)28(35)20-4-6-21(7-5-20)29(36)37/h1-3,8-15,20-21H,4-7,16-18H2,(H,36,37)/t20-,21-,30-/m1/s1 NZDHORBXJJHDJW-URCPOSBSSA-N 253123 US9458171, 83 Nuclear receptor ROR-gamma [262-507] 4819 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253123 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253123&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217581 346547491 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440625 OC(c1ccc(cc1)[C@]1(CCN(C1)C(=O)N1CCOCC1)S(=O)(=O)c1ccc(F)cc1)(C(F)(F)F)C(F)(F)F InChI=1S/C24H23F7N2O5S/c25-18-5-7-19(8-6-18)39(36,37)21(9-10-33(15-21)20(34)32-11-13-38-14-12-32)16-1-3-17(4-2-16)22(35,23(26,27)28)24(29,30)31/h1-8,35H,9-15H2/t21-/m1/s1 YURMZNYTCUYKOC-OAQYLSRUSA-N 253124 US9458171, 84 Nuclear receptor ROR-gamma [262-507] 31 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253124 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253124&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 131636471 346547492 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440626 CS(=O)(=O)N1CCC(C1)(c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C20H18F7NO5S2/c1-34(30,31)28-11-10-17(12-28,35(32,33)16-8-6-15(21)7-9-16)13-2-4-14(5-3-13)18(29,19(22,23)24)20(25,26)27/h2-9,29H,10-12H2,1H3 IOLBLEHHVNHTCN-UHFFFAOYSA-N 253125 US9458171, 85 Nuclear receptor ROR-gamma [262-507] 223 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253125 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253125&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217583 346547493 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440627 CS(=O)(=O)N1CCC(C1)(c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccccc1 InChI=1S/C20H19F6NO5S2/c1-33(29,30)27-12-11-17(13-27,34(31,32)16-5-3-2-4-6-16)14-7-9-15(10-8-14)18(28,19(21,22)23)20(24,25)26/h2-10,28H,11-13H2,1H3 LBFJPHVBMKFYAI-UHFFFAOYSA-N 253126 US9458171, 86 Nuclear receptor ROR-gamma [262-507] 785 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253126 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253126&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217584 346547494 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440628 OC(c1ccc(cc1)C1(CCN(C1)S(=O)(=O)c1ccc(F)cc1)S(=O)(=O)c1ccccc1)(C(F)(F)F)C(F)(F)F InChI=1S/C25H20F7NO5S2/c26-19-10-12-21(13-11-19)40(37,38)33-15-14-22(16-33,39(35,36)20-4-2-1-3-5-20)17-6-8-18(9-7-17)23(34,24(27,28)29)25(30,31)32/h1-13,34H,14-16H2 XXJMYQRGWOMLSN-UHFFFAOYSA-N 253127 US9458171, 87 Nuclear receptor ROR-gamma [262-507] 1414 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253127 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253127&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217587 346547495 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440629 OC(=O)CCC(=O)N1CC[C@](C1)(c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C23H19F8NO5S/c24-16-5-7-17(8-6-16)38(36,37)20(11-12-32(13-20)18(33)9-10-19(34)35)14-1-3-15(4-2-14)21(25,22(26,27)28)23(29,30)31/h1-8H,9-13H2,(H,34,35)/t20-/m0/s1 BBJFJXCZUARTEE-FQEVSTJZSA-N 253128 US9458171, 88 Nuclear receptor ROR-gamma [262-507] 934 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253128 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253128&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217585 346547496 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440630 CC(C)(O)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C23H21F8NO4S/c1-19(2,34)18(33)32-12-11-20(13-32,37(35,36)17-9-7-16(24)8-10-17)14-3-5-15(6-4-14)21(25,22(26,27)28)23(29,30)31/h3-10,34H,11-13H2,1-2H3/t20-/m0/s1 QUURJIGQKSGQJZ-FQEVSTJZSA-N 253129 US9458171, 89 Nuclear receptor ROR-gamma [262-507] 355 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253129 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253129&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217586 346547497 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440631 CC(C)(N)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C23H22F8N2O3S/c1-19(2,32)18(34)33-12-11-20(13-33,37(35,36)17-9-7-16(24)8-10-17)14-3-5-15(6-4-14)21(25,22(26,27)28)23(29,30)31/h3-10H,11-13,32H2,1-2H3/t20-/m0/s1 AEFQVPIYKFEQAP-FQEVSTJZSA-N 253130 US9458171, 90 Nuclear receptor ROR-gamma [262-507] 958 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253130 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253130&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217588 346547498 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440632 NC1(CCCC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C25H24F8N2O3S/c26-18-7-9-19(10-8-18)39(37,38)22(13-14-35(15-22)20(36)21(34)11-1-2-12-21)16-3-5-17(6-4-16)23(27,24(28,29)30)25(31,32)33/h3-10H,1-2,11-15,34H2/t22-/m0/s1 XQDBTOZUHSONFS-QFIPXVFZSA-N 253131 US9458171, 91 Nuclear receptor ROR-gamma [262-507] 843 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253131 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253131&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217589 346547499 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440633 CC(C)(C(=O)N1CC[C@](C1)(c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1)n1cncn1 InChI=1S/C25H22F8N4O3S/c1-21(2,37-15-34-14-35-37)20(38)36-12-11-22(13-36,41(39,40)19-9-7-18(26)8-10-19)16-3-5-17(6-4-16)23(27,24(28,29)30)25(31,32)33/h3-10,14-15H,11-13H2,1-2H3/t22-/m0/s1 CBKXOFCIKODTNM-QFIPXVFZSA-N 253132 US9458171, 92 Nuclear receptor ROR-gamma [262-507] 173 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253132 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253132&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217592 346547500 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440634 CC(C)(C(=O)N1CC[C@](C1)(c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1)n1cccn1 InChI=1S/C26H23F8N3O3S/c1-22(2,37-14-3-13-35-37)21(38)36-15-12-23(16-36,41(39,40)20-10-8-19(27)9-11-20)17-4-6-18(7-5-17)24(28,25(29,30)31)26(32,33)34/h3-11,13-14H,12,15-16H2,1-2H3/t23-/m0/s1 BGBZIXNYEAISJB-QHCPKHFHSA-N 253133 US9458171, 93::US9458171, 94 Nuclear receptor ROR-gamma [262-507] 645 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253133 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253133&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217590 346547501 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440635 CC(C)(C(=O)N1CC[C@](C1)(c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1)n1cccn1 InChI=1S/C26H23F8N3O3S/c1-22(2,37-14-3-13-35-37)21(38)36-15-12-23(16-36,41(39,40)20-10-8-19(27)9-11-20)17-4-6-18(7-5-17)24(28,25(29,30)31)26(32,33)34/h3-11,13-14H,12,15-16H2,1-2H3/t23-/m0/s1 BGBZIXNYEAISJB-QHCPKHFHSA-N 253133 US9458171, 93::US9458171, 94 Nuclear receptor ROR-gamma [262-507] 63 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253133 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253133&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217590 346547501 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440636 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C27H25F8NO5S/c28-20-9-11-21(12-10-20)42(40,41)24(13-14-36(15-24)22(37)16-1-3-17(4-2-16)23(38)39)18-5-7-19(8-6-18)25(29,26(30,31)32)27(33,34)35/h5-12,16-17H,1-4,13-15H2,(H,38,39)/t16-,17-,24-/m0/s1 AVHWMAVUUHFRKE-UAVUOLJFSA-N 253135 US9458171, 95 Nuclear receptor ROR-gamma [262-507] 49 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253135 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253135&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search O5A 6P9F 118208018 346547502 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440637 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(cc1)C#N InChI=1S/C28H25F7N2O5S/c29-26(27(30,31)32,28(33,34)35)21-9-7-20(8-10-21)25(43(41,42)22-11-1-17(15-36)2-12-22)13-14-37(16-25)23(38)18-3-5-19(6-4-18)24(39)40/h1-2,7-12,18-19H,3-6,13-14,16H2,(H,39,40)/t18-,19-,25-/m0/s1 CMKGWMJXVGGHGD-MHPIHPPYSA-N 253136 US9458171, 96 Nuclear receptor ROR-gamma [262-507] 151 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253136 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253136&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217591 346547503 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440638 COc1ccc(cc1)S(=O)(=O)[C@]1(CCN(C1)C(=O)[C@H]1CC[C@@H](CC1)C(O)=O)c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F InChI=1S/C28H28F7NO6S/c1-42-21-10-12-22(13-11-21)43(40,41)25(14-15-36(16-25)23(37)17-2-4-18(5-3-17)24(38)39)19-6-8-20(9-7-19)26(29,27(30,31)32)28(33,34)35/h6-13,17-18H,2-5,14-16H2,1H3,(H,38,39)/t17-,18-,25-/m0/s1 PHWSECSLTQRKEH-RPPIVITFSA-N 253137 US9458171, 97 Nuclear receptor ROR-gamma [262-507] 190 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253137 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253137&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217593 346547504 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440639 OC(=O)[C@H]1CC[C@H](CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C27H25F8NO5S/c28-20-9-11-21(12-10-20)42(40,41)24(13-14-36(15-24)22(37)16-1-3-17(4-2-16)23(38)39)18-5-7-19(8-6-18)25(29,26(30,31)32)27(33,34)35/h5-12,16-17H,1-4,13-15H2,(H,38,39)/t16-,17+,24-/m0/s1 AVHWMAVUUHFRKE-SRGWNRLKSA-N 253138 US9458171, 100::US9458171, 98::US9458171, 99 Nuclear receptor ROR-gamma [262-507] 545 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253138 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253138&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118208018 346547505 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440640 OC(=O)[C@H]1CC[C@H](CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C27H25F8NO5S/c28-20-9-11-21(12-10-20)42(40,41)24(13-14-36(15-24)22(37)16-1-3-17(4-2-16)23(38)39)18-5-7-19(8-6-18)25(29,26(30,31)32)27(33,34)35/h5-12,16-17H,1-4,13-15H2,(H,38,39)/t16-,17+,24-/m0/s1 AVHWMAVUUHFRKE-SRGWNRLKSA-N 253138 US9458171, 100::US9458171, 98::US9458171, 99 Nuclear receptor ROR-gamma [262-507] 59 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253138 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253138&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118208018 346547505 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440641 OC(=O)[C@H]1CC[C@H](CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C27H25F8NO5S/c28-20-9-11-21(12-10-20)42(40,41)24(13-14-36(15-24)22(37)16-1-3-17(4-2-16)23(38)39)18-5-7-19(8-6-18)25(29,26(30,31)32)27(33,34)35/h5-12,16-17H,1-4,13-15H2,(H,38,39)/t16-,17+,24-/m0/s1 AVHWMAVUUHFRKE-SRGWNRLKSA-N 253138 US9458171, 100::US9458171, 98::US9458171, 99 Nuclear receptor ROR-gamma [262-507] 758 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253138 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253138&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118208018 346547505 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440642 OC(=O)C1CCC(O)(CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C27H25F8NO6S/c28-19-5-7-20(8-6-19)43(41,42)24(17-1-3-18(4-2-17)25(29,26(30,31)32)27(33,34)35)13-14-36(15-24)22(39)23(40)11-9-16(10-12-23)21(37)38/h1-8,16,40H,9-15H2,(H,37,38)/t16?,23?,24-/m0/s1 BOILSPDFARREIP-ZBYWLKIMSA-N 253141 US9458171, 101 Nuclear receptor ROR-gamma [262-507] 17 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253141 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253141&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217595 346547506 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440643 OC(=O)C1CCC(O)(CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C27H25F8NO6S/c28-19-5-7-20(8-6-19)43(41,42)24(17-1-3-18(4-2-17)25(29,26(30,31)32)27(33,34)35)13-14-36(15-24)22(39)23(40)11-9-16(10-12-23)21(37)38/h1-8,16,40H,9-15H2,(H,37,38)/t16?,23?,24-/m0/s1 BOILSPDFARREIP-ZBYWLKIMSA-N 253142 US9458171, 102 Nuclear receptor ROR-gamma [262-507] 74 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253142 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253142&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217595 346547507 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440644 NC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C27H26F8N2O4S/c28-20-9-11-21(12-10-20)42(40,41)24(13-14-37(15-24)23(39)17-3-1-16(2-4-17)22(36)38)18-5-7-19(8-6-18)25(29,26(30,31)32)27(33,34)35/h5-12,16-17H,1-4,13-15H2,(H2,36,38)/t16-,17-,24-/m0/s1 PPAUGFBGWSYFQG-UAVUOLJFSA-N 253143 US9458171, 103 Nuclear receptor ROR-gamma [262-507] 148 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253143 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253143&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217594 346547508 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440645 CC(=O)N1CCC(CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C27H26F8N2O4S/c1-17(38)36-13-10-18(11-14-36)23(39)37-15-12-24(16-37,42(40,41)22-8-6-21(28)7-9-22)19-2-4-20(5-3-19)25(29,26(30,31)32)27(33,34)35/h2-9,18H,10-16H2,1H3/t24-/m0/s1 ZCVYLZVBYDUMQY-DEOSSOPVSA-N 253144 US9458171, 104 Nuclear receptor ROR-gamma [262-507] 48 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253144 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253144&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217596 346547509 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440646 CC(=O)N1CCC(CC1)(C(N)=O)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H27F8N3O5S/c1-17(40)38-13-10-24(11-14-38,22(37)41)23(42)39-15-12-25(16-39,45(43,44)21-8-6-20(29)7-9-21)18-2-4-19(5-3-18)26(30,27(31,32)33)28(34,35)36/h2-9H,10-16H2,1H3,(H2,37,41)/t25-/m0/s1 NEDYDJTZHOJTNQ-VWLOTQADSA-N 253145 US9458171, 105 Nuclear receptor ROR-gamma [262-507] 59 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253145 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253145&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217597 346547510 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440647 CC(=O)N1CCC(O)(CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C27H26F8N2O5S/c1-17(38)36-13-10-23(40,11-14-36)22(39)37-15-12-24(16-37,43(41,42)21-8-6-20(28)7-9-21)18-2-4-19(5-3-18)25(29,26(30,31)32)27(33,34)35/h2-9,40H,10-16H2,1H3/t24-/m0/s1 ZGCYOKCXHXNKDJ-DEOSSOPVSA-N 253146 US9458171, 106 Nuclear receptor ROR-gamma [262-507] 49 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253146 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253146&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217598 346547511 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440648 OC1(CCOCC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C25H23F8NO5S/c26-18-5-7-19(8-6-18)40(37,38)22(9-12-34(15-22)20(35)21(36)10-13-39-14-11-21)16-1-3-17(4-2-16)23(27,24(28,29)30)25(31,32)33/h1-8,36H,9-15H2/t22-/m0/s1 ZAJAIOIIRXVRGH-QFIPXVFZSA-N 253147 US9458171, 107 Nuclear receptor ROR-gamma [262-507] 111 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253147 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253147&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217599 346547512 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440649 OCC1(CCOCC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C26H25F8NO5S/c27-19-5-7-20(8-6-19)41(38,39)23(9-12-35(15-23)21(37)22(16-36)10-13-40-14-11-22)17-1-3-18(4-2-17)24(28,25(29,30)31)26(32,33)34/h1-8,36H,9-16H2/t23-/m0/s1 CSNDKUCTMXIQPM-QHCPKHFHSA-N 253148 US9458171, 108 Nuclear receptor ROR-gamma [262-507] 53 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253148 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253148&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217601 346547513 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440650 NC1(CCOCC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C25H24F8N2O4S/c26-18-5-7-19(8-6-18)40(37,38)22(9-12-35(15-22)20(36)21(34)10-13-39-14-11-21)16-1-3-17(4-2-16)23(27,24(28,29)30)25(31,32)33/h1-8H,9-15,34H2/t22-/m0/s1 FRKQJONYSRGMIZ-QFIPXVFZSA-N 253149 US9458171, 109 Nuclear receptor ROR-gamma [262-507] 51 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253149 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253149&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217603 346547514 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440651 CC(=O)NC1(CCOCC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C27H26F8N2O5S/c1-17(38)36-23(11-14-42-15-12-23)22(39)37-13-10-24(16-37,43(40,41)21-8-6-20(28)7-9-21)18-2-4-19(5-3-18)25(29,26(30,31)32)27(33,34)35/h2-9H,10-16H2,1H3,(H,36,38)/t24-/m0/s1 QNSXLVUSWZHKFJ-DEOSSOPVSA-N 253150 US9458171, 110 Nuclear receptor ROR-gamma [262-507] 559 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253150 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253150&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217600 346547515 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440652 Fc1ccc(cc1)S(=O)(=O)[C@]1(CCN(C1)C(=O)C1(CCOCC1)C#N)c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F InChI=1S/C26H22F8N2O4S/c27-19-5-7-20(8-6-19)41(38,39)23(9-12-36(16-23)21(37)22(15-35)10-13-40-14-11-22)17-1-3-18(4-2-17)24(28,25(29,30)31)26(32,33)34/h1-8H,9-14,16H2/t23-/m0/s1 XKGNVFXKSAUAHQ-QHCPKHFHSA-N 253151 US9458171, 111 Nuclear receptor ROR-gamma [262-507] 287 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253151 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253151&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217602 346547516 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440653 NC(=O)C1(CCOCC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C26H24F8N2O5S/c27-18-5-7-19(8-6-18)42(39,40)23(9-12-36(15-23)21(38)22(20(35)37)10-13-41-14-11-22)16-1-3-17(4-2-16)24(28,25(29,30)31)26(32,33)34/h1-8H,9-15H2,(H2,35,37)/t23-/m0/s1 HKVJLLCPQXKSAY-QHCPKHFHSA-N 253152 US9458171, 112 Nuclear receptor ROR-gamma [262-507] 55 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253152 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253152&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217604 346547517 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440654 Fc1ccc(cc1)S(=O)(=O)[C@]1(CCN(C1)C(=O)c1ccncc1)c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F InChI=1S/C25H18F8N2O3S/c26-19-5-7-20(8-6-19)39(37,38)22(11-14-35(15-22)21(36)16-9-12-34-13-10-16)17-1-3-18(4-2-17)23(27,24(28,29)30)25(31,32)33/h1-10,12-13H,11,14-15H2/t22-/m0/s1 NCJPRDUCVPEPHV-QFIPXVFZSA-N 253153 US9458171, 113 Nuclear receptor ROR-gamma [262-507] 287 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253153 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253153&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217605 346547518 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440655 Fc1ccc(cc1)S(=O)(=O)[C@]1(CCN(C1)C(=O)Cc1ccncc1)c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F InChI=1S/C26H20F8N2O3S/c27-20-5-7-21(8-6-20)40(38,39)23(11-14-36(16-23)22(37)15-17-9-12-35-13-10-17)18-1-3-19(4-2-18)24(28,25(29,30)31)26(32,33)34/h1-10,12-13H,11,14-16H2/t23-/m0/s1 RVTXAXWBRDSCEU-QHCPKHFHSA-N 253154 US9458171, 114 Nuclear receptor ROR-gamma [262-507] 33 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253154 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253154&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217606 346547519 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440656 Fc1ccc(cc1)S(=O)(=O)[C@]1(CCN(C1)C(=O)N1CCC(CC1)C#N)c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F InChI=1S/C26H23F8N3O3S/c27-20-5-7-21(8-6-20)41(39,40)23(11-14-37(16-23)22(38)36-12-9-17(15-35)10-13-36)18-1-3-19(4-2-18)24(28,25(29,30)31)26(32,33)34/h1-8,17H,9-14,16H2/t23-/m0/s1 UIHVVFWCPLQNCP-QHCPKHFHSA-N 253155 US9458171, 115 Nuclear receptor ROR-gamma [262-507] 40 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253155 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253155&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217607 346547520 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440657 CC(=O)N1CCN(CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C26H25F8N3O4S/c1-17(38)35-12-14-36(15-13-35)22(39)37-11-10-23(16-37,42(40,41)21-8-6-20(27)7-9-21)18-2-4-19(5-3-18)24(28,25(29,30)31)26(32,33)34/h2-9H,10-16H2,1H3/t23-/m0/s1 AENFRJUKGBLCPJ-QHCPKHFHSA-N 253156 US9458171, 116 Nuclear receptor ROR-gamma [262-507] 32 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253156 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253156&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217608 346547521 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440658 Cc1cc(ccc1F)S(=O)(=O)[C@]1(CCN(C1)C(=O)[C@H]1CC[C@@H](CC1)C(O)=O)c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F InChI=1S/C28H27F8NO5S/c1-16-14-21(10-11-22(16)29)43(41,42)25(12-13-37(15-25)23(38)17-2-4-18(5-3-17)24(39)40)19-6-8-20(9-7-19)26(30,27(31,32)33)28(34,35)36/h6-11,14,17-18H,2-5,12-13,15H2,1H3,(H,39,40)/t17-,18-,25-/m0/s1 FOMZHKMHJLHIQZ-RPPIVITFSA-N 253157 US9458171, 117 Nuclear receptor ROR-gamma [262-507] 16 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253157 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253157&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217609 346547522 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440659 CCc1cc(ccc1F)S(=O)(=O)[C@@]1(CCN(C1)C(=O)[C@H]1CC[C@@H](CC1)C(O)=O)c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F InChI=1S/C29H29F8NO5S/c1-2-17-15-22(11-12-23(17)30)44(42,43)26(13-14-38(16-26)24(39)18-3-5-19(6-4-18)25(40)41)20-7-9-21(10-8-20)27(31,28(32,33)34)29(35,36)37/h7-12,15,18-19H,2-6,13-14,16H2,1H3,(H,40,41)/t18-,19-,26-/m1/s1 IMASCFKPOMBBQD-LJKQEARRSA-N 253158 US9458171, 118 Nuclear receptor ROR-gamma [262-507] 870 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253158 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253158&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217610 346547523 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440660 CCc1cc(ccc1F)S(=O)(=O)[C@]1(CCN(C1)C(=O)[C@H]1CC[C@@H](CC1)C(O)=O)c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F InChI=1S/C29H29F8NO5S/c1-2-17-15-22(11-12-23(17)30)44(42,43)26(13-14-38(16-26)24(39)18-3-5-19(6-4-18)25(40)41)20-7-9-21(10-8-20)27(31,28(32,33)34)29(35,36)37/h7-12,15,18-19H,2-6,13-14,16H2,1H3,(H,40,41)/t18-,19-,26-/m0/s1 IMASCFKPOMBBQD-DGUDUIIESA-N 253159 US9458171, 119 Nuclear receptor ROR-gamma [262-507] 42 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253159 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253159&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217611 346547524 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440661 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)c(c1)C1CC1 InChI=1S/C30H29F8NO5S/c31-24-12-11-22(15-23(24)17-1-2-17)45(43,44)27(13-14-39(16-27)25(40)18-3-5-19(6-4-18)26(41)42)20-7-9-21(10-8-20)28(32,29(33,34)35)30(36,37)38/h7-12,15,17-19H,1-6,13-14,16H2,(H,41,42)/t18-,19-,27-/m0/s1 LWEFWPKVZAGQGI-BATDWUPUSA-N 253160 US9458171, 120 Nuclear receptor ROR-gamma [262-507] 141 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253160 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253160&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217612 346547525 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440662 Fc1cccc(F)c1COC(c1ccc(cc1)C1(CCNC1)S(=O)(=O)c1ccccc1)(C(F)(F)F)C(F)(F)F InChI=1S/C26H21F8NO3S/c27-21-7-4-8-22(28)20(21)15-38-24(25(29,30)31,26(32,33)34)18-11-9-17(10-12-18)23(13-14-35-16-23)39(36,37)19-5-2-1-3-6-19/h1-12,35H,13-16H2 FOKLOOSUEKEIJK-UHFFFAOYSA-N 253161 US9458171, 121 Nuclear receptor ROR-gamma [262-507] 119 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253161 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253161&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217620 346547526 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440663 Fc1ccc(cc1)S(=O)(=O)[C@@]1(CCN(C1)c1ncc(cn1)C#N)c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F InChI=1S/C31H21F9N4O3S/c32-22-8-10-23(11-9-22)48(45,46)28(12-13-44(18-28)27-42-15-19(14-41)16-43-27)20-4-6-21(7-5-20)29(30(35,36)37,31(38,39)40)47-17-24-25(33)2-1-3-26(24)34/h1-11,15-16H,12-13,17-18H2/t28-/m1/s1 BGIMWUINTMBXKQ-MUUNZHRXSA-N 253162 US9458171, 122 Nuclear receptor ROR-gamma [262-507] 192 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253162 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253162&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217621 346547527 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440664 Fc1ccc(cc1)S(=O)(=O)[C@]1(CCN(C1)c1ncc(cn1)C#N)c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F InChI=1S/C31H21F9N4O3S/c32-22-8-10-23(11-9-22)48(45,46)28(12-13-44(18-28)27-42-15-19(14-41)16-43-27)20-4-6-21(7-5-20)29(30(35,36)37,31(38,39)40)47-17-24-25(33)2-1-3-26(24)34/h1-11,15-16H,12-13,17-18H2/t28-/m0/s1 BGIMWUINTMBXKQ-NDEPHWFRSA-N 253163 US9458171, 123 Nuclear receptor ROR-gamma [262-507] 24 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253163 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253163&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217613 346547528 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440665 Fc1ccc(cc1)S(=O)(=O)C1(CCN(CC=C)C1)c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F InChI=1S/C29H24F9NO3S/c1-2-15-39-16-14-26(18-39,43(40,41)22-12-10-21(30)11-13-22)19-6-8-20(9-7-19)27(28(33,34)35,29(36,37)38)42-17-23-24(31)4-3-5-25(23)32/h2-13H,1,14-18H2 YEGUUVCZFBVYDH-UHFFFAOYSA-N 253164 US9458171, 124 Nuclear receptor ROR-gamma [262-507] 51 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253164 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253164&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217622 346547529 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440666 NC(=O)CN1CCC(C1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H23F9N2O4S/c29-19-8-10-20(11-9-19)44(41,42)25(12-13-39(16-25)14-24(38)40)17-4-6-18(7-5-17)26(27(32,33)34,28(35,36)37)43-15-21-22(30)2-1-3-23(21)31/h1-11H,12-16H2,(H2,38,40) DATCEPKYXXFCEH-UHFFFAOYSA-N 253165 US9458171, 125 Nuclear receptor ROR-gamma [262-507] 106 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253165 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253165&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217615 346547530 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440667 NC(=O)CN1CC[C@@](C1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H23F9N2O4S/c29-19-8-10-20(11-9-19)44(41,42)25(12-13-39(16-25)14-24(38)40)17-4-6-18(7-5-17)26(27(32,33)34,28(35,36)37)43-15-21-22(30)2-1-3-23(21)31/h1-11H,12-16H2,(H2,38,40)/t25-/m1/s1 DATCEPKYXXFCEH-RUZDIDTESA-N 253166 US9458171, 126 Nuclear receptor ROR-gamma [262-507] 76 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253166 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253166&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217614 346547531 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440668 NC(=O)CN1CC[C@](C1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H23F9N2O4S/c29-19-8-10-20(11-9-19)44(41,42)25(12-13-39(16-25)14-24(38)40)17-4-6-18(7-5-17)26(27(32,33)34,28(35,36)37)43-15-21-22(30)2-1-3-23(21)31/h1-11H,12-16H2,(H2,38,40)/t25-/m0/s1 DATCEPKYXXFCEH-VWLOTQADSA-N 253167 US9458171, 127 Nuclear receptor ROR-gamma [262-507] 35 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253167 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253167&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217616 346547532 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440669 CCNC(=O)CN1CCC(C1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C30H27F9N2O4S/c1-2-40-26(42)16-41-15-14-27(18-41,46(43,44)22-12-10-21(31)11-13-22)19-6-8-20(9-7-19)28(29(34,35)36,30(37,38)39)45-17-23-24(32)4-3-5-25(23)33/h3-13H,2,14-18H2,1H3,(H,40,42) LGBFBKFZXKFNCO-UHFFFAOYSA-N 253168 US9458171, 128 Nuclear receptor ROR-gamma [262-507] 47 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253168 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253168&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118218266 346547533 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440670 Fc1ccc(cc1)S(=O)(=O)C1(CCN(CC(=O)N2CCCC2)C1)c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F InChI=1S/C32H29F9N2O4S/c33-23-10-12-24(13-11-23)48(45,46)29(14-17-42(20-29)18-28(44)43-15-1-2-16-43)21-6-8-22(9-7-21)30(31(36,37)38,32(39,40)41)47-19-25-26(34)4-3-5-27(25)35/h3-13H,1-2,14-20H2 JHKPBXOHLCPUNS-UHFFFAOYSA-N 253169 US9458171, 129 Nuclear receptor ROR-gamma [262-507] 41 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253169 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253169&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217617 346547534 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440671 CC(=O)N1CCC(C1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccccc1 InChI=1S/C28H23F8NO4S/c1-18(38)37-15-14-25(17-37,42(39,40)21-6-3-2-4-7-21)19-10-12-20(13-11-19)26(27(31,32)33,28(34,35)36)41-16-22-23(29)8-5-9-24(22)30/h2-13H,14-17H2,1H3 FRYQPJFSHDNEMK-UHFFFAOYSA-N 253170 US9458171, 130 Nuclear receptor ROR-gamma [262-507] 365 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253170 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253170&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217618 346547535 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440672 COCC(=O)N1CCC(C1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccccc1 InChI=1S/C29H25F8NO5S/c1-42-17-25(39)38-15-14-26(18-38,44(40,41)21-6-3-2-4-7-21)19-10-12-20(13-11-19)27(28(32,33)34,29(35,36)37)43-16-22-23(30)8-5-9-24(22)31/h2-13H,14-18H2,1H3 WOIQNRHOKYSMEY-UHFFFAOYSA-N 253171 US9458171, 131 Nuclear receptor ROR-gamma [262-507] 172 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253171 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253171&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217619 346547536 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440673 COCC(=O)N1CCC(C1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C29H24F9NO5S/c1-43-16-25(40)39-14-13-26(17-39,45(41,42)21-11-9-20(30)10-12-21)18-5-7-19(8-6-18)27(28(33,34)35,29(36,37)38)44-15-22-23(31)3-2-4-24(22)32/h2-12H,13-17H2,1H3 PQTUNKBAMFIOIQ-UHFFFAOYSA-N 253172 US9458171, 132 Nuclear receptor ROR-gamma [262-507] 97 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253172 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253172&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217626 346547537 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440674 Fc1ccc(cc1)S(=O)(=O)C1(CCN(C1)C(=O)CC#N)c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F InChI=1S/C29H21F9N2O4S/c30-20-8-10-21(11-9-20)45(42,43)26(13-15-40(17-26)25(41)12-14-39)18-4-6-19(7-5-18)27(28(33,34)35,29(36,37)38)44-16-22-23(31)2-1-3-24(22)32/h1-11H,12-13,15-17H2 PAHUSUQFCOFQBL-UHFFFAOYSA-N 253173 US9458171, 133 Nuclear receptor ROR-gamma [262-507] 150 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253173 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253173&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217623 346547538 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440675 OCC(=O)N1CCC(C1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H22F9NO5S/c29-19-8-10-20(11-9-19)44(41,42)25(12-13-38(16-25)24(40)14-39)17-4-6-18(7-5-17)26(27(32,33)34,28(35,36)37)43-15-21-22(30)2-1-3-23(21)31/h1-11,39H,12-16H2 PJVKUPPCXVLLEH-UHFFFAOYSA-N 253174 US9458171, 134 Nuclear receptor ROR-gamma [262-507] 92 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253174 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253174&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217627 346547539 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440676 CN(C)CC(=O)N1CCC(C1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccccc1 InChI=1S/C30H28F8N2O4S/c1-39(2)17-26(41)40-16-15-27(19-40,45(42,43)22-7-4-3-5-8-22)20-11-13-21(14-12-20)28(29(33,34)35,30(36,37)38)44-18-23-24(31)9-6-10-25(23)32/h3-14H,15-19H2,1-2H3 WPQSPDUNJPYVLH-UHFFFAOYSA-N 253175 US9458171, 135 Nuclear receptor ROR-gamma [262-507] 461 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253175 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253175&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217624 346547540 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440677 CC(C)C(=O)N1CCC(C1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C30H26F9NO4S/c1-18(2)26(41)40-15-14-27(17-40,45(42,43)22-12-10-21(31)11-13-22)19-6-8-20(9-7-19)28(29(34,35)36,30(37,38)39)44-16-23-24(32)4-3-5-25(23)33/h3-13,18H,14-17H2,1-2H3 ASNMYSKEUXVIBQ-UHFFFAOYSA-N 253176 US9458171, 136 Nuclear receptor ROR-gamma [262-507] 152 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253176 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253176&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217625 346547541 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440678 CC(C)(O)C(=O)N1CCC(C1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C30H26F9NO5S/c1-26(2,42)25(41)40-15-14-27(17-40,46(43,44)21-12-10-20(31)11-13-21)18-6-8-19(9-7-18)28(29(34,35)36,30(37,38)39)45-16-22-23(32)4-3-5-24(22)33/h3-13,42H,14-17H2,1-2H3 OYNHZXSXTMTGAB-UHFFFAOYSA-N 253177 US9458171, 137 Nuclear receptor ROR-gamma [262-507] 36 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253177 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253177&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217630 346547542 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440679 CC(C)(O)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C30H26F9NO5S/c1-26(2,42)25(41)40-15-14-27(17-40,46(43,44)21-12-10-20(31)11-13-21)18-6-8-19(9-7-18)28(29(34,35)36,30(37,38)39)45-16-22-23(32)4-3-5-24(22)33/h3-13,42H,14-17H2,1-2H3/t27-/m0/s1 OYNHZXSXTMTGAB-MHZLTWQESA-N 253178 US9458171, 138 Nuclear receptor ROR-gamma [262-507] 52 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253178 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253178&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217633 346547543 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440680 CC(C)(CO)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C31H28F9NO5S/c1-27(2,18-42)26(43)41-15-14-28(17-41,47(44,45)22-12-10-21(32)11-13-22)19-6-8-20(9-7-19)29(30(35,36)37,31(38,39)40)46-16-23-24(33)4-3-5-25(23)34/h3-13,42H,14-18H2,1-2H3/t28-/m0/s1 IQHSBVRCFXXFKI-NDEPHWFRSA-N 253179 US9458171, 139 Nuclear receptor ROR-gamma [262-507] 142 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253179 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253179&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217628 346547544 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440681 CC(CO)(CO)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C31H28F9NO6S/c1-27(17-42,18-43)26(44)41-14-13-28(16-41,48(45,46)22-11-9-21(32)10-12-22)19-5-7-20(8-6-19)29(30(35,36)37,31(38,39)40)47-15-23-24(33)3-2-4-25(23)34/h2-12,42-43H,13-18H2,1H3/t28-/m0/s1 USEUQYBGGFZCKA-NDEPHWFRSA-N 253180 US9458171, 140 Nuclear receptor ROR-gamma [262-507] 116 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253180 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253180&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217629 346547545 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440682 NC(=O)C(=O)N1CCC(C1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H21F9N2O5S/c29-18-8-10-19(11-9-18)45(42,43)25(12-13-39(15-25)24(41)23(38)40)16-4-6-17(7-5-16)26(27(32,33)34,28(35,36)37)44-14-20-21(30)2-1-3-22(20)31/h1-11H,12-15H2,(H2,38,40) MCRNYZNMDPKYPD-UHFFFAOYSA-N 253181 US9458171, 141 Nuclear receptor ROR-gamma [262-507] 73 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253181 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253181&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217631 346547546 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440683 CNC(=O)C(=O)N1CCC(C1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C29H23F9N2O5S/c1-39-24(41)25(42)40-14-13-26(16-40,46(43,44)20-11-9-19(30)10-12-20)17-5-7-18(8-6-17)27(28(33,34)35,29(36,37)38)45-15-21-22(31)3-2-4-23(21)32/h2-12H,13-16H2,1H3,(H,39,41) DRZPRBHRJCIKFO-UHFFFAOYSA-N 253182 US9458171, 142 Nuclear receptor ROR-gamma [262-507] 74 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253182 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253182&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118218308 346547547 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440684 Fc1ccc(cc1)S(=O)(=O)C1(CCN(C1)C(=O)C1CNC1)c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F InChI=1S/C30H25F9N2O4S/c31-21-8-10-22(11-9-21)46(43,44)27(12-13-41(17-27)26(42)18-14-40-15-18)19-4-6-20(7-5-19)28(29(34,35)36,30(37,38)39)45-16-23-24(32)2-1-3-25(23)33/h1-11,18,40H,12-17H2 KIPALSCLAAICRP-UHFFFAOYSA-N 253183 US9458171, 143 Nuclear receptor ROR-gamma [262-507] 1359 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253183 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253183&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217632 346547548 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440685 CC(=O)N1CC(C1)C(=O)N1CCC(C1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C32H27F9N2O5S/c1-19(44)43-15-20(16-43)28(45)42-14-13-29(18-42,49(46,47)24-11-9-23(33)10-12-24)21-5-7-22(8-6-21)30(31(36,37)38,32(39,40)41)48-17-25-26(34)3-2-4-27(25)35/h2-12,20H,13-18H2,1H3 PEHYFVRCRZKMOD-UHFFFAOYSA-N 253184 US9458171, 144 Nuclear receptor ROR-gamma [262-507] 60 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253184 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253184&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217634 346547549 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440686 CS(=O)(=O)N1CC(C1)C(=O)N1CCC(C1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C31H27F9N2O6S2/c1-49(44,45)42-15-19(16-42)27(43)41-14-13-28(18-41,50(46,47)23-11-9-22(32)10-12-23)20-5-7-21(8-6-20)29(30(35,36)37,31(38,39)40)48-17-24-25(33)3-2-4-26(24)34/h2-12,19H,13-18H2,1H3 MAVMOERJEQWRGE-UHFFFAOYSA-N 253185 US9458171, 145 Nuclear receptor ROR-gamma [262-507] 74 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253185 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253185&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217636 346547550 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440687 CC(C)(C)OC(=O)N1CC(C1)C(=O)N1CCC(C1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C35H33F9N2O6S/c1-31(2,3)52-30(48)46-17-21(18-46)29(47)45-16-15-32(20-45,53(49,50)25-13-11-24(36)12-14-25)22-7-9-23(10-8-22)33(34(39,40)41,35(42,43)44)51-19-26-27(37)5-4-6-28(26)38/h4-14,21H,15-20H2,1-3H3 CBUHNAXRNMOVOH-UHFFFAOYSA-N 253186 US9458171, 146 Nuclear receptor ROR-gamma [262-507] 140 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253186 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253186&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217635 346547551 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440688 OC(=O)C1CC2(C1)CC(C2)C(=O)N1CCC(C1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C35H30F9NO6S/c36-24-8-10-25(11-9-24)52(49,50)32(12-13-45(19-32)29(46)20-14-31(15-20)16-21(17-31)30(47)48)22-4-6-23(7-5-22)33(34(39,40)41,35(42,43)44)51-18-26-27(37)2-1-3-28(26)38/h1-11,20-21H,12-19H2,(H,47,48) YMXPSOKWRMXCRD-UHFFFAOYSA-N 253187 US9458171, 147 Nuclear receptor ROR-gamma [262-507] 69 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253187 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253187&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 131636472 346547552 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440689 OC(=O)C1CC2(C1)CC(C2)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C35H30F9NO6S/c36-24-8-10-25(11-9-24)52(49,50)32(12-13-45(19-32)29(46)20-14-31(15-20)16-21(17-31)30(47)48)22-4-6-23(7-5-22)33(34(39,40)41,35(42,43)44)51-18-26-27(37)2-1-3-28(26)38/h1-11,20-21H,12-19H2,(H,47,48)/t20?,21?,31?,32-/m0/s1 YMXPSOKWRMXCRD-AZDLHLSDSA-N 253188 US9458171, 148 Nuclear receptor ROR-gamma [262-507] 32 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253188 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253188&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217637 346547553 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440690 OC(=O)C1CC2(C1)CC(C2)C(=O)N1CC[C@@](C1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C35H30F9NO6S/c36-24-8-10-25(11-9-24)52(49,50)32(12-13-45(19-32)29(46)20-14-31(15-20)16-21(17-31)30(47)48)22-4-6-23(7-5-22)33(34(39,40)41,35(42,43)44)51-18-26-27(37)2-1-3-28(26)38/h1-11,20-21H,12-19H2,(H,47,48)/t20?,21?,31?,32-/m1/s1 YMXPSOKWRMXCRD-ZDUZPHFRSA-N 253189 US9458171, 149 Nuclear receptor ROR-gamma [262-507] 32 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253189 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253189&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 131636473 346547554 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440691 OC(=O)C1CCC(C1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C33H28F9NO6S/c34-23-10-12-24(13-11-23)50(47,48)30(14-15-43(18-30)28(44)19-4-5-20(16-19)29(45)46)21-6-8-22(9-7-21)31(32(37,38)39,33(40,41)42)49-17-25-26(35)2-1-3-27(25)36/h1-3,6-13,19-20H,4-5,14-18H2,(H,45,46)/t19?,20?,30-/m0/s1 GKWILCWTAHTJOW-KJRWMQPKSA-N 253190 US9458171, 150 Nuclear receptor ROR-gamma [262-507] 157 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253190 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253190&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217638 346547555 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440692 CC(=O)N1CC[C@H](C1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C33H29F9N2O5S/c1-20(45)43-15-13-21(17-43)29(46)44-16-14-30(19-44,50(47,48)25-11-9-24(34)10-12-25)22-5-7-23(8-6-22)31(32(37,38)39,33(40,41)42)49-18-26-27(35)3-2-4-28(26)36/h2-12,21H,13-19H2,1H3/t21-,30+/m1/s1 NOMFZKMOYVWWES-DFXYEROKSA-N 253191 US9458171, 151 Nuclear receptor ROR-gamma [262-507] 121 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253191 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253191&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217640 346547556 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440693 OCC(=O)N1CC[C@H](C1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C33H29F9N2O6S/c34-23-8-10-24(11-9-23)51(48,49)30(13-15-44(19-30)29(47)20-12-14-43(16-20)28(46)17-45)21-4-6-22(7-5-21)31(32(37,38)39,33(40,41)42)50-18-25-26(35)2-1-3-27(25)36/h1-11,20,45H,12-19H2/t20-,30+/m1/s1 LMXBQWSVEYURDG-KEEVHDRGSA-N 253192 US9458171, 152 Nuclear receptor ROR-gamma [262-507] 90 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253192 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253192&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217639 346547557 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440694 Fc1ccc(cc1)S(=O)(=O)[C@]1(CCN(C1)C(=O)[C@@H]1CCN(C1)C(=O)CC#N)c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F InChI=1S/C34H28F9N3O5S/c35-24-8-10-25(11-9-24)52(49,50)31(14-17-46(20-31)30(48)21-13-16-45(18-21)29(47)12-15-44)22-4-6-23(7-5-22)32(33(38,39)40,34(41,42)43)51-19-26-27(36)2-1-3-28(26)37/h1-11,21H,12-14,16-20H2/t21-,31+/m1/s1 XGWAQTHTPKNYLZ-UKPGIYTDSA-N 253193 US9458171, 153 Nuclear receptor ROR-gamma [262-507] 241 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253193 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253193&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217641 346547558 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440695 CS(=O)(=O)N1CC[C@H](C1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C32H29F9N2O6S2/c1-50(45,46)43-15-13-20(17-43)28(44)42-16-14-29(19-42,51(47,48)24-11-9-23(33)10-12-24)21-5-7-22(8-6-21)30(31(36,37)38,32(39,40)41)49-18-25-26(34)3-2-4-27(25)35/h2-12,20H,13-19H2,1H3/t20-,29+/m1/s1 RUXOCEHIRFIFLG-OLILMLBXSA-N 253194 US9458171, 154 Nuclear receptor ROR-gamma [262-507] 42 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253194 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253194&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217642 346547559 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440696 CC(=O)N1CC[C@@H](C1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C33H29F9N2O5S/c1-20(45)43-15-13-21(17-43)29(46)44-16-14-30(19-44,50(47,48)25-11-9-24(34)10-12-25)22-5-7-23(8-6-22)31(32(37,38)39,33(40,41)42)49-18-26-27(35)3-2-4-28(26)36/h2-12,21H,13-19H2,1H3/t21-,30-/m0/s1 NOMFZKMOYVWWES-JRPXNJEYSA-N 253195 US9458171, 155 Nuclear receptor ROR-gamma [262-507] 55 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253195 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253195&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217643 346547560 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440697 OCC(=O)N1CC[C@@H](C1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C33H29F9N2O6S/c34-23-8-10-24(11-9-23)51(48,49)30(13-15-44(19-30)29(47)20-12-14-43(16-20)28(46)17-45)21-4-6-22(7-5-21)31(32(37,38)39,33(40,41)42)50-18-25-26(35)2-1-3-27(25)36/h1-11,20,45H,12-19H2/t20-,30-/m0/s1 LMXBQWSVEYURDG-WRGVRERRSA-N 253196 US9458171, 156 Nuclear receptor ROR-gamma [262-507] 71 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253196 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253196&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217644 346547561 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440698 Fc1ccc(cc1)S(=O)(=O)[C@]1(CCN(C1)C(=O)[C@H]1CCN(C1)C(=O)CC#N)c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F InChI=1S/C34H28F9N3O5S/c35-24-8-10-25(11-9-24)52(49,50)31(14-17-46(20-31)30(48)21-13-16-45(18-21)29(47)12-15-44)22-4-6-23(7-5-22)32(33(38,39)40,34(41,42)43)51-19-26-27(36)2-1-3-28(26)37/h1-11,21H,12-14,16-20H2/t21-,31-/m0/s1 XGWAQTHTPKNYLZ-BGOLNKOXSA-N 253197 US9458171, 157 Nuclear receptor ROR-gamma [262-507] 121 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253197 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253197&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217645 346547562 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440699 CS(=O)(=O)N1CC[C@@H](C1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C32H29F9N2O6S2/c1-50(45,46)43-15-13-20(17-43)28(44)42-16-14-29(19-42,51(47,48)24-11-9-23(33)10-12-24)21-5-7-22(8-6-21)30(31(36,37)38,32(39,40)41)49-18-25-26(34)3-2-4-27(25)35/h2-12,20H,13-19H2,1H3/t20-,29-/m0/s1 RUXOCEHIRFIFLG-WRONEBCDSA-N 253198 US9458171, 158 Nuclear receptor ROR-gamma [262-507] 174 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253198 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253198&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217647 346547563 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440700 OC(=O)[C@H]1CC[C@H](CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C34H30F9NO6S/c35-24-12-14-25(15-13-24)51(48,49)31(16-17-44(19-31)29(45)20-4-6-21(7-5-20)30(46)47)22-8-10-23(11-9-22)32(33(38,39)40,34(41,42)43)50-18-26-27(36)2-1-3-28(26)37/h1-3,8-15,20-21H,4-7,16-19H2,(H,46,47)/t20-,21+,31-/m0/s1 BFZCOFNHRDYFJK-LPYUBCQDSA-N 253199 US9458171, 159 Nuclear receptor ROR-gamma [262-507] 142 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253199 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253199&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217646 346547564 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440701 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C34H30F9NO6S/c35-24-12-14-25(15-13-24)51(48,49)31(16-17-44(19-31)29(45)20-4-6-21(7-5-20)30(46)47)22-8-10-23(11-9-22)32(33(38,39)40,34(41,42)43)50-18-26-27(36)2-1-3-28(26)37/h1-3,8-15,20-21H,4-7,16-19H2,(H,46,47)/t20-,21-,31-/m0/s1 BFZCOFNHRDYFJK-IHPVIADISA-N 253200 US9458171, 160 Nuclear receptor ROR-gamma [262-507] 85 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253200 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253200&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217646 346547565 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440702 OC(=O)C1CCCC(C1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C34H30F9NO6S/c35-24-11-13-25(14-12-24)51(48,49)31(15-16-44(19-31)29(45)20-3-1-4-21(17-20)30(46)47)22-7-9-23(10-8-22)32(33(38,39)40,34(41,42)43)50-18-26-27(36)5-2-6-28(26)37/h2,5-14,20-21H,1,3-4,15-19H2,(H,46,47)/t20?,21?,31-/m0/s1 NUFIHLLWVINAQH-RNNXAFDXSA-N 253201 US9458171, 161 Nuclear receptor ROR-gamma [262-507] 141 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253201 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253201&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217648 346547566 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440703 Fc1ccc(cc1)S(=O)(=O)C1(CCN(C1)C(=O)C1CCNCC1)c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F InChI=1S/C32H29F9N2O4S/c33-23-8-10-24(11-9-23)48(45,46)29(14-17-43(19-29)28(44)20-12-15-42-16-13-20)21-4-6-22(7-5-21)30(31(36,37)38,32(39,40)41)47-18-25-26(34)2-1-3-27(25)35/h1-11,20,42H,12-19H2 SAZZDNJEDZAWGS-UHFFFAOYSA-N 253202 US9458171, 162 Nuclear receptor ROR-gamma [262-507] 960 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253202 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253202&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217649 346547567 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440704 CN1CCC(CC1)C(=O)N1CCC(C1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C33H31F9N2O4S/c1-43-16-13-21(14-17-43)29(45)44-18-15-30(20-44,49(46,47)25-11-9-24(34)10-12-25)22-5-7-23(8-6-22)31(32(37,38)39,33(40,41)42)48-19-26-27(35)3-2-4-28(26)36/h2-12,21H,13-20H2,1H3 KZDOSUMQMGCPIS-UHFFFAOYSA-N 253203 US9458171, 163 Nuclear receptor ROR-gamma [262-507] 311 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253203 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253203&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217650 346547568 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440705 CN1CCC(CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C33H31F9N2O4S/c1-43-16-13-21(14-17-43)29(45)44-18-15-30(20-44,49(46,47)25-11-9-24(34)10-12-25)22-5-7-23(8-6-22)31(32(37,38)39,33(40,41)42)48-19-26-27(35)3-2-4-28(26)36/h2-12,21H,13-20H2,1H3/t30-/m0/s1 KZDOSUMQMGCPIS-PMERELPUSA-N 253204 US9458171, 164 Nuclear receptor ROR-gamma [262-507] 195 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253204 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253204&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217651 346547569 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440706 CN1CCC(C)(CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C34H33F9N2O4S/c1-30(14-17-44(2)18-15-30)29(46)45-19-16-31(21-45,50(47,48)25-12-10-24(35)11-13-25)22-6-8-23(9-7-22)32(33(38,39)40,34(41,42)43)49-20-26-27(36)4-3-5-28(26)37/h3-13H,14-21H2,1-2H3/t31-/m0/s1 QYLZZCCWMOZVGO-HKBQPEDESA-N 253205 US9458171, 165 Nuclear receptor ROR-gamma [262-507] 612 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253205 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253205&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217652 346547570 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440707 Fc1ccc(cc1)S(=O)(=O)[C@]1(CCN(C1)C(=O)C1CCN(CC1)c1ccncc1)c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F InChI=1S/C37H32F9N3O4S/c38-27-8-10-29(11-9-27)54(51,52)34(16-21-49(23-34)33(50)24-14-19-48(20-15-24)28-12-17-47-18-13-28)25-4-6-26(7-5-25)35(36(41,42)43,37(44,45)46)53-22-30-31(39)2-1-3-32(30)40/h1-13,17-18,24H,14-16,19-23H2/t34-/m0/s1 UJLDWECLNKBGTA-UMSFTDKQSA-N 253206 US9458171, 166 Nuclear receptor ROR-gamma [262-507] 1604 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253206 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253206&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217653 346547571 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440708 Fc1ccc(cc1)S(=O)(=O)[C@]1(CCN(C1)C(=O)C1CCN(CC1)C=O)c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F InChI=1S/C33H29F9N2O5S/c34-24-8-10-25(11-9-24)50(47,48)30(14-17-44(19-30)29(46)21-12-15-43(20-45)16-13-21)22-4-6-23(7-5-22)31(32(37,38)39,33(40,41)42)49-18-26-27(35)2-1-3-28(26)36/h1-11,20-21H,12-19H2/t30-/m0/s1 IJQNEHBMANCUPT-PMERELPUSA-N 253207 US9458171, 167 Nuclear receptor ROR-gamma [262-507] 136 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253207 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253207&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217654 346547572 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440709 CC(=O)N1CCC(CC1)C(=O)N1CCC(C1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C34H31F9N2O5S/c1-21(46)44-16-13-22(14-17-44)30(47)45-18-15-31(20-45,51(48,49)26-11-9-25(35)10-12-26)23-5-7-24(8-6-23)32(33(38,39)40,34(41,42)43)50-19-27-28(36)3-2-4-29(27)37/h2-12,22H,13-20H2,1H3 QHLZLJRQIZGAKA-UHFFFAOYSA-N 253208 US9458171, 168 Nuclear receptor ROR-gamma [262-507] 120 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253208 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253208&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217655 346547573 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440710 CC(=O)N1CCC(CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C34H31F9N2O5S/c1-21(46)44-16-13-22(14-17-44)30(47)45-18-15-31(20-45,51(48,49)26-11-9-25(35)10-12-26)23-5-7-24(8-6-23)32(33(38,39)40,34(41,42)43)50-19-27-28(36)3-2-4-29(27)37/h2-12,22H,13-20H2,1H3/t31-/m0/s1 QHLZLJRQIZGAKA-HKBQPEDESA-N 253209 US9458171, 169 Nuclear receptor ROR-gamma [262-507] 78 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253209 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253209&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217656 346547574 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440711 CC(=O)N1CCC(CC1)C(=O)N1CC[C@@](C1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C34H31F9N2O5S/c1-21(46)44-16-13-22(14-17-44)30(47)45-18-15-31(20-45,51(48,49)26-11-9-25(35)10-12-26)23-5-7-24(8-6-23)32(33(38,39)40,34(41,42)43)50-19-27-28(36)3-2-4-29(27)37/h2-12,22H,13-20H2,1H3/t31-/m1/s1 QHLZLJRQIZGAKA-WJOKGBTCSA-N 253210 US9458171, 170 Nuclear receptor ROR-gamma [262-507] 358 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253210 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253210&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217657 346547575 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440712 CC(=O)N1CCC(C)(CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C35H33F9N2O5S/c1-22(47)45-17-14-31(2,15-18-45)30(48)46-19-16-32(21-46,52(49,50)26-12-10-25(36)11-13-26)23-6-8-24(9-7-23)33(34(39,40)41,35(42,43)44)51-20-27-28(37)4-3-5-29(27)38/h3-13H,14-21H2,1-2H3/t32-/m0/s1 LOEKGZIWKVJYER-YTTGMZPUSA-N 253211 US9458171, 171 Nuclear receptor ROR-gamma [262-507] 141 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253211 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253211&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217658 346547576 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440713 CCC1(CCN(CC1)C(C)=O)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C36H35F9N2O5S/c1-3-32(15-18-46(19-16-32)23(2)48)31(49)47-20-17-33(22-47,53(50,51)27-13-11-26(37)12-14-27)24-7-9-25(10-8-24)34(35(40,41)42,36(43,44)45)52-21-28-29(38)5-4-6-30(28)39/h4-14H,3,15-22H2,1-2H3/t33-/m0/s1 WMUZUNCUWTVCLQ-XIFFEERXSA-N 253212 US9458171, 172 Nuclear receptor ROR-gamma [262-507] 222 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253212 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253212&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217659 346547577 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440714 CC(=O)N1CCC(CC1)(C(=O)N1CC[C@](C1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1)c1ccccc1 InChI=1S/C40H35F9N2O5S/c1-26(52)50-21-18-36(19-22-50,27-6-3-2-4-7-27)35(53)51-23-20-37(25-51,57(54,55)31-16-14-30(41)15-17-31)28-10-12-29(13-11-28)38(39(44,45)46,40(47,48)49)56-24-32-33(42)8-5-9-34(32)43/h2-17H,18-25H2,1H3/t37-/m0/s1 XJDZJCKJDMBKSY-QNGWXLTQSA-N 253213 US9458171, 173 Nuclear receptor ROR-gamma [262-507] 471 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253213 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253213&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217660 346547578 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440715 CC(=O)N1CCC(N)(CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C34H32F9N3O5S/c1-21(47)45-16-13-30(44,14-17-45)29(48)46-18-15-31(20-46,52(49,50)25-11-9-24(35)10-12-25)22-5-7-23(8-6-22)32(33(38,39)40,34(41,42)43)51-19-26-27(36)3-2-4-28(26)37/h2-12H,13-20,44H2,1H3/t31-/m0/s1 BXNGFPJPGMRKCM-HKBQPEDESA-N 253214 US9458171, 174 Nuclear receptor ROR-gamma [262-507] 40 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253214 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253214&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217661 346547579 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440716 CC(=O)NC1(CCN(CC1)C(C)=O)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C36H34F9N3O6S/c1-22(49)46-32(14-17-47(18-15-32)23(2)50)31(51)48-19-16-33(21-48,55(52,53)27-12-10-26(37)11-13-27)24-6-8-25(9-7-24)34(35(40,41)42,36(43,44)45)54-20-28-29(38)4-3-5-30(28)39/h3-13H,14-21H2,1-2H3,(H,46,49)/t33-/m0/s1 QVTZHYDQIVCHAU-XIFFEERXSA-N 253215 US9458171, 175 Nuclear receptor ROR-gamma [262-507] 133 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253215 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253215&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217662 346547580 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440717 OCC(=O)N1CCC(CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C34H31F9N2O6S/c35-24-8-10-25(11-9-24)52(49,50)31(14-17-45(20-31)30(48)21-12-15-44(16-13-21)29(47)18-46)22-4-6-23(7-5-22)32(33(38,39)40,34(41,42)43)51-19-26-27(36)2-1-3-28(26)37/h1-11,21,46H,12-20H2/t31-/m0/s1 XZYKJFYPSKGDAX-HKBQPEDESA-N 253216 US9458171, 176 Nuclear receptor ROR-gamma [262-507] 267 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253216 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253216&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217663 346547581 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440718 Fc1ccc(cc1)S(=O)(=O)[C@]1(CCN(C1)C(=O)C1CCN(CC1)C(=O)CC#N)c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F InChI=1S/C35H30F9N3O5S/c36-25-8-10-26(11-9-25)53(50,51)32(15-19-47(21-32)31(49)22-13-17-46(18-14-22)30(48)12-16-45)23-4-6-24(7-5-23)33(34(39,40)41,35(42,43)44)52-20-27-28(37)2-1-3-29(27)38/h1-11,22H,12-15,17-21H2/t32-/m0/s1 XHXKWETVSJEZEG-YTTGMZPUSA-N 253217 US9458171, 177 Nuclear receptor ROR-gamma [262-507] 221 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253217 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253217&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217664 346547582 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440719 OC(=O)C(=O)N1CCC(CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C34H29F9N2O7S/c35-23-8-10-24(11-9-23)53(50,51)31(14-17-45(19-31)28(46)20-12-15-44(16-13-20)29(47)30(48)49)21-4-6-22(7-5-21)32(33(38,39)40,34(41,42)43)52-18-25-26(36)2-1-3-27(25)37/h1-11,20H,12-19H2,(H,48,49)/t31-/m0/s1 DIMYHLSQBYNBRQ-HKBQPEDESA-N 253218 US9458171, 178 Nuclear receptor ROR-gamma [262-507] 57 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253218 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253218&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217665 346547583 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440720 NC(=O)C(=O)N1CCC(CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C34H30F9N3O6S/c35-23-8-10-24(11-9-23)53(50,51)31(14-17-46(19-31)29(48)20-12-15-45(16-13-20)30(49)28(44)47)21-4-6-22(7-5-21)32(33(38,39)40,34(41,42)43)52-18-25-26(36)2-1-3-27(25)37/h1-11,20H,12-19H2,(H2,44,47)/t31-/m0/s1 ZWBNOHPUZZJYSA-HKBQPEDESA-N 253219 US9458171, 179 Nuclear receptor ROR-gamma [262-507] 202 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253219 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253219&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217666 346547584 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440721 CNC(=O)C(=O)N1CCC(CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C35H32F9N3O6S/c1-45-29(48)31(50)46-16-13-21(14-17-46)30(49)47-18-15-32(20-47,54(51,52)25-11-9-24(36)10-12-25)22-5-7-23(8-6-22)33(34(39,40)41,35(42,43)44)53-19-26-27(37)3-2-4-28(26)38/h2-12,21H,13-20H2,1H3,(H,45,48)/t32-/m0/s1 STNCAVHTAGRRFK-YTTGMZPUSA-N 253220 US9458171, 180 Nuclear receptor ROR-gamma [262-507] 106 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253220 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253220&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217667 346547585 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440722 NC(=O)N1CCC(CC1)C(=O)N1CCC(C1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C33H30F9N3O5S/c34-23-8-10-24(11-9-23)51(48,49)30(14-17-45(19-30)28(46)20-12-15-44(16-13-20)29(43)47)21-4-6-22(7-5-21)31(32(37,38)39,33(40,41)42)50-18-25-26(35)2-1-3-27(25)36/h1-11,20H,12-19H2,(H2,43,47) ITFHMWNKBWVAFU-UHFFFAOYSA-N 253221 US9458171, 181 Nuclear receptor ROR-gamma [262-507] 56 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253221 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253221&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217668 346547586 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440723 NC(=O)N1CCC(CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C33H30F9N3O5S/c34-23-8-10-24(11-9-23)51(48,49)30(14-17-45(19-30)28(46)20-12-15-44(16-13-20)29(43)47)21-4-6-22(7-5-21)31(32(37,38)39,33(40,41)42)50-18-25-26(35)2-1-3-27(25)36/h1-11,20H,12-19H2,(H2,43,47)/t30-/m0/s1 ITFHMWNKBWVAFU-PMERELPUSA-N 253222 US9458171, 182 Nuclear receptor ROR-gamma [262-507] 79 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253222 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253222&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217669 346547587 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440724 CS(=O)(=O)N1CCC(CC1)C(=O)N1CCC(C1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C33H31F9N2O6S2/c1-51(46,47)44-16-13-21(14-17-44)29(45)43-18-15-30(20-43,52(48,49)25-11-9-24(34)10-12-25)22-5-7-23(8-6-22)31(32(37,38)39,33(40,41)42)50-19-26-27(35)3-2-4-28(26)36/h2-12,21H,13-20H2,1H3 PYTHKUHXIRQPET-UHFFFAOYSA-N 253223 US9458171, 183 Nuclear receptor ROR-gamma [262-507] 104 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253223 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253223&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217670 346547588 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440725 CS(=O)(=O)N1CCC(CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C33H31F9N2O6S2/c1-51(46,47)44-16-13-21(14-17-44)29(45)43-18-15-30(20-43,52(48,49)25-11-9-24(34)10-12-25)22-5-7-23(8-6-22)31(32(37,38)39,33(40,41)42)50-19-26-27(35)3-2-4-28(26)36/h2-12,21H,13-20H2,1H3/t30-/m0/s1 PYTHKUHXIRQPET-PMERELPUSA-N 253224 US9458171, 184 Nuclear receptor ROR-gamma [262-507] 140 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253224 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253224&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217671 346547589 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440726 CN1CCC(CC1=O)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C33H29F9N2O5S/c1-43-15-13-20(17-28(43)45)29(46)44-16-14-30(19-44,50(47,48)24-11-9-23(34)10-12-24)21-5-7-22(8-6-21)31(32(37,38)39,33(40,41)42)49-18-25-26(35)3-2-4-27(25)36/h2-12,20H,13-19H2,1H3/t20?,30-/m0/s1 RYWZGYXQNDSTOP-QOWRFBDLSA-N 253225 US9458171, 185 Nuclear receptor ROR-gamma [262-507] 41 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253225 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253225&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217672 346547590 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440727 Fc1ccc(cc1)S(=O)(=O)[C@]1(CCN(C1)C(=O)C1CCOCC1)c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F InChI=1S/C32H28F9NO5S/c33-23-8-10-24(11-9-23)48(44,45)29(14-15-42(19-29)28(43)20-12-16-46-17-13-20)21-4-6-22(7-5-21)30(31(36,37)38,32(39,40)41)47-18-25-26(34)2-1-3-27(25)35/h1-11,20H,12-19H2/t29-/m0/s1 QKBOGWLTELXFIN-LJAQVGFWSA-N 253226 US9458171, 186 Nuclear receptor ROR-gamma [262-507] 55 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253226 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253226&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217673 346547591 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440728 NC1(CCOCC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C32H29F9N2O5S/c33-22-8-10-23(11-9-22)49(45,46)29(12-15-43(19-29)27(44)28(42)13-16-47-17-14-28)20-4-6-21(7-5-20)30(31(36,37)38,32(39,40)41)48-18-24-25(34)2-1-3-26(24)35/h1-11H,12-19,42H2/t29-/m0/s1 FSCCTNMQVLPYFM-LJAQVGFWSA-N 253227 US9458171, 187 Nuclear receptor ROR-gamma [262-507] 51 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253227 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253227&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217674 346547592 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440729 CC(=O)NC1(CCOCC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C34H31F9N2O6S/c1-21(46)44-30(14-17-50-18-15-30)29(47)45-16-13-31(20-45,52(48,49)25-11-9-24(35)10-12-25)22-5-7-23(8-6-22)32(33(38,39)40,34(41,42)43)51-19-26-27(36)3-2-4-28(26)37/h2-12H,13-20H2,1H3,(H,44,46)/t31-/m0/s1 NHQHRIVHBPSBGE-HKBQPEDESA-N 253228 US9458171, 188 Nuclear receptor ROR-gamma [262-507] 151 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253228 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253228&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217675 346547593 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440730 OC1(CCOCC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C32H28F9NO6S/c33-22-8-10-23(11-9-22)49(45,46)29(12-15-42(19-29)27(43)28(44)13-16-47-17-14-28)20-4-6-21(7-5-20)30(31(36,37)38,32(39,40)41)48-18-24-25(34)2-1-3-26(24)35/h1-11,44H,12-19H2/t29-/m0/s1 SAPGWGNZGRMJNX-LJAQVGFWSA-N 253229 US9458171, 189 Nuclear receptor ROR-gamma [262-507] 71 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253229 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253229&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217676 346547594 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440731 Fc1ccc(cc1)S(=O)(=O)C1(CCN(C1)C(=O)c1ccccc1)c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F InChI=1S/C33H24F9NO4S/c34-24-13-15-25(16-14-24)48(45,46)30(17-18-43(20-30)29(44)21-5-2-1-3-6-21)22-9-11-23(12-10-22)31(32(37,38)39,33(40,41)42)47-19-26-27(35)7-4-8-28(26)36/h1-16H,17-20H2 BNBWZAHLRKWBFS-UHFFFAOYSA-N 253230 US9458171, 190 Nuclear receptor ROR-gamma [262-507] 230 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253230 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253230&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217677 346547595 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440732 CN(C)c1ccc(cc1)C(=O)N1CCC(C1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C35H29F9N2O4S/c1-45(2)26-14-6-22(7-15-26)31(47)46-19-18-32(21-46,51(48,49)27-16-12-25(36)13-17-27)23-8-10-24(11-9-23)33(34(39,40)41,35(42,43)44)50-20-28-29(37)4-3-5-30(28)38/h3-17H,18-21H2,1-2H3 ZOVBXWMBEAIDEH-UHFFFAOYSA-N 253231 US9458171, 191 Nuclear receptor ROR-gamma [262-507] 179 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253231 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253231&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217678 346547596 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440733 CN(C)c1cccc(c1)C(=O)N1CCC(C1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C35H29F9N2O4S/c1-45(2)26-6-3-5-22(19-26)31(47)46-18-17-32(21-46,51(48,49)27-15-13-25(36)14-16-27)23-9-11-24(12-10-23)33(34(39,40)41,35(42,43)44)50-20-28-29(37)7-4-8-30(28)38/h3-16,19H,17-18,20-21H2,1-2H3 WVJAWDLHLURXTB-UHFFFAOYSA-N 253232 US9458171, 192 Nuclear receptor ROR-gamma [262-507] 531 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253232 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253232&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217679 346547597 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440734 OC(=O)c1ccc(cc1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C34H24F9NO6S/c35-24-12-14-25(15-13-24)51(48,49)31(16-17-44(19-31)29(45)20-4-6-21(7-5-20)30(46)47)22-8-10-23(11-9-22)32(33(38,39)40,34(41,42)43)50-18-26-27(36)2-1-3-28(26)37/h1-15H,16-19H2,(H,46,47)/t31-/m0/s1 GULWTLRXELGHTF-HKBQPEDESA-N 253233 US9458171, 193 Nuclear receptor ROR-gamma [262-507] 46 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253233 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253233&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217680 346547598 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440735 COC(=O)c1ccc(cc1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C35H26F9NO6S/c1-50-31(47)22-7-5-21(6-8-22)30(46)45-18-17-32(20-45,52(48,49)26-15-13-25(36)14-16-26)23-9-11-24(12-10-23)33(34(39,40)41,35(42,43)44)51-19-27-28(37)3-2-4-29(27)38/h2-16H,17-20H2,1H3/t32-/m0/s1 RRCKIOCZBJJSMO-YTTGMZPUSA-N 253234 US9458171, 194 Nuclear receptor ROR-gamma [262-507] 221 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253234 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253234&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217681 346547599 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440736 Fc1ccc(cc1)S(=O)(=O)[C@]1(CCN(C1)C(=O)c1ccc2C(=O)NS(=O)(=O)c2c1)c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F InChI=1S/C34H23F9N2O7S2/c35-22-9-11-23(12-10-22)53(48,49)31(14-15-45(18-31)30(47)19-4-13-24-28(16-19)54(50,51)44-29(24)46)20-5-7-21(8-6-20)32(33(38,39)40,34(41,42)43)52-17-25-26(36)2-1-3-27(25)37/h1-13,16H,14-15,17-18H2,(H,44,46)/t31-/m0/s1 WTIKZGSTAGVNFG-HKBQPEDESA-N 253235 US9458171, 195 Nuclear receptor ROR-gamma [262-507] 28 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253235 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253235&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217686 346547600 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440737 Fc1ccc(cc1)S(=O)(=O)[C@]1(CCN(C1)C(=O)c1ccncc1)c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F InChI=1S/C32H23F9N2O4S/c33-23-8-10-24(11-9-23)48(45,46)29(14-17-43(19-29)28(44)20-12-15-42-16-13-20)21-4-6-22(7-5-21)30(31(36,37)38,32(39,40)41)47-18-25-26(34)2-1-3-27(25)35/h1-13,15-16H,14,17-19H2/t29-/m0/s1 OEUPZUJCSFXCPP-LJAQVGFWSA-N 253236 US9458171, 196 Nuclear receptor ROR-gamma [262-507] 137 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253236 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253236&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217683 346547601 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440738 Fc1ccc(cc1)S(=O)(=O)[C@]1(CCN(C1)C(=O)c1cccnc1)c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F InChI=1S/C32H23F9N2O4S/c33-23-10-12-24(13-11-23)48(45,46)29(14-16-43(19-29)28(44)20-3-2-15-42-17-20)21-6-8-22(9-7-21)30(31(36,37)38,32(39,40)41)47-18-25-26(34)4-1-5-27(25)35/h1-13,15,17H,14,16,18-19H2/t29-/m0/s1 OMIKIPGYHXIKKK-LJAQVGFWSA-N 253237 US9458171, 197 Nuclear receptor ROR-gamma [262-507] 182 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253237 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253237&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217687 346547602 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440739 Fc1ccc(cc1)S(=O)(=O)C1(CCN(C1)C(=O)Cc1ccccc1)c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F InChI=1S/C34H26F9NO4S/c35-25-13-15-26(16-14-25)49(46,47)31(17-18-44(21-31)30(45)19-22-5-2-1-3-6-22)23-9-11-24(12-10-23)32(33(38,39)40,34(41,42)43)48-20-27-28(36)7-4-8-29(27)37/h1-16H,17-21H2 FKTABENIRKCKIL-UHFFFAOYSA-N 253238 US9458171, 198 Nuclear receptor ROR-gamma [262-507] 209 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253238 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253238&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217682 346547603 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440740 OC(=O)c1ccc(CC(=O)N2CC[C@](C2)(c2ccc(cc2)C(OCc2c(F)cccc2F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c2ccc(F)cc2)cc1 InChI=1S/C35H26F9NO6S/c36-25-12-14-26(15-13-25)52(49,50)32(16-17-45(20-32)30(46)18-21-4-6-22(7-5-21)31(47)48)23-8-10-24(11-9-23)33(34(39,40)41,35(42,43)44)51-19-27-28(37)2-1-3-29(27)38/h1-15H,16-20H2,(H,47,48)/t32-/m0/s1 OHRXGPGNTBJJOL-YTTGMZPUSA-N 253239 US9458171, 199 Nuclear receptor ROR-gamma [262-507] 133 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253239 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253239&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217688 346547604 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440741 NC(=O)c1ccc(CC(=O)N2CC[C@](C2)(c2ccc(cc2)C(OCc2c(F)cccc2F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c2ccc(F)cc2)cc1 InChI=1S/C35H27F9N2O5S/c36-25-12-14-26(15-13-25)52(49,50)32(16-17-46(20-32)30(47)18-21-4-6-22(7-5-21)31(45)48)23-8-10-24(11-9-23)33(34(39,40)41,35(42,43)44)51-19-27-28(37)2-1-3-29(27)38/h1-15H,16-20H2,(H2,45,48)/t32-/m0/s1 LLGYELXYRLOEOG-YTTGMZPUSA-N 253240 US9458171, 200 Nuclear receptor ROR-gamma [262-507] 171 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253240 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253240&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217684 346547605 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440742 CCS(=O)(=O)c1ccc(CC(=O)N2CC[C@@](C2)(c2ccc(cc2)C(OCc2c(F)cccc2F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c2ccc(F)cc2)cc1 InChI=1S/C36H30F9NO6S2/c1-2-53(48,49)27-14-6-23(7-15-27)20-32(47)46-19-18-33(22-46,54(50,51)28-16-12-26(37)13-17-28)24-8-10-25(11-9-24)34(35(40,41)42,36(43,44)45)52-21-29-30(38)4-3-5-31(29)39/h3-17H,2,18-22H2,1H3/t33-/m1/s1 JZNDYASFMUZIGO-MGBGTMOVSA-N 253241 US9458171, 201 Nuclear receptor ROR-gamma [262-507] 60 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253241 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253241&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217685 346547606 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440743 CCS(=O)(=O)c1ccc(CC(=O)N2CC[C@](C2)(c2ccc(cc2)C(OCc2c(F)cccc2F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c2ccc(F)cc2)cc1 InChI=1S/C36H30F9NO6S2/c1-2-53(48,49)27-14-6-23(7-15-27)20-32(47)46-19-18-33(22-46,54(50,51)28-16-12-26(37)13-17-28)24-8-10-25(11-9-24)34(35(40,41)42,36(43,44)45)52-21-29-30(38)4-3-5-31(29)39/h3-17H,2,18-22H2,1H3/t33-/m0/s1 JZNDYASFMUZIGO-XIFFEERXSA-N 253242 US9458171, 202 Nuclear receptor ROR-gamma [262-507] 32 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253242 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253242&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217689 346547607 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440744 Fc1ccc(cc1)S(=O)(=O)[C@]1(CCN(C1)C(=O)Cc1cccnc1)c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F InChI=1S/C33H25F9N2O4S/c34-24-10-12-25(13-11-24)49(46,47)30(14-16-44(20-30)29(45)17-21-3-2-15-43-18-21)22-6-8-23(9-7-22)31(32(37,38)39,33(40,41)42)48-19-26-27(35)4-1-5-28(26)36/h1-13,15,18H,14,16-17,19-20H2/t30-/m0/s1 NQQRTDUVFQVZOS-PMERELPUSA-N 253243 US9458171, 203 Nuclear receptor ROR-gamma [262-507] 130 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253243 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253243&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217690 346547608 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440745 Fc1ccc(cc1)S(=O)(=O)[C@]1(CCN(C1)C(=O)Cc1ccncc1)c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F InChI=1S/C33H25F9N2O4S/c34-24-8-10-25(11-9-24)49(46,47)30(14-17-44(20-30)29(45)18-21-12-15-43-16-13-21)22-4-6-23(7-5-22)31(32(37,38)39,33(40,41)42)48-19-26-27(35)2-1-3-28(26)36/h1-13,15-16H,14,17-20H2/t30-/m0/s1 UIBIHJSXPUUBBK-PMERELPUSA-N 253244 US9458171, 204 Nuclear receptor ROR-gamma [262-507] 101 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253244 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253244&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217692 346547609 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440746 [O-][n+]1ccc(CC(=O)N2CC[C@](C2)(c2ccc(cc2)C(OCc2c(F)cccc2F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c2ccc(F)cc2)cc1 InChI=1S/C33H25F9N2O5S/c34-24-8-10-25(11-9-24)50(47,48)30(14-17-43(20-30)29(45)18-21-12-15-44(46)16-13-21)22-4-6-23(7-5-22)31(32(37,38)39,33(40,41)42)49-19-26-27(35)2-1-3-28(26)36/h1-13,15-16H,14,17-20H2/t30-/m0/s1 SBGUZXBJDNQSQA-PMERELPUSA-N 253245 US9458171, 205 Nuclear receptor ROR-gamma [262-507] 89 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253245 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253245&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 131636474 346547610 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440747 CC(C)(C(=O)N1CC[C@](C1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1)c1ccncc1 InChI=1S/C35H29F9N2O4S/c1-31(2,22-14-17-45-18-15-22)30(47)46-19-16-32(21-46,51(48,49)26-12-10-25(36)11-13-26)23-6-8-24(9-7-23)33(34(39,40)41,35(42,43)44)50-20-27-28(37)4-3-5-29(27)38/h3-15,17-18H,16,19-21H2,1-2H3/t32-/m0/s1 AVIYHFLDTRTMOL-YTTGMZPUSA-N 253246 US9458171, 206 Nuclear receptor ROR-gamma [262-507] 56 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253246 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253246&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217691 346547611 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440748 Nc1nnc(CC(=O)N2CC[C@](C2)(c2ccc(cc2)C(OCc2c(F)cccc2F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c2ccc(F)cc2)[nH]1 253247 US9458171, 207 Nuclear receptor ROR-gamma [262-507] 437 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253247 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253247&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217693 346547612 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440749 Cc1nonc1CC(=O)N1CC[C@](C1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C31H24F9N3O5S/c1-18-26(42-48-41-18)15-27(44)43-14-13-28(17-43,49(45,46)22-11-9-21(32)10-12-22)19-5-7-20(8-6-19)29(30(35,36)37,31(38,39)40)47-16-23-24(33)3-2-4-25(23)34/h2-12H,13-17H2,1H3/t28-/m0/s1 MCFPBHAUMXJJQT-NDEPHWFRSA-N 253248 US9458171, 208 Nuclear receptor ROR-gamma [262-507] 33 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253248 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253248&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217694 346547613 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440750 Oc1cc(CC(=O)N2CC[C@](C2)(c2ccc(cc2)C(OCc2c(F)cccc2F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c2ccc(F)cc2)nc(O)n1 InChI=1S/C32H24F9N3O6S/c33-20-8-10-22(11-9-20)51(48,49)29(12-13-44(17-29)27(46)15-21-14-26(45)43-28(47)42-21)18-4-6-19(7-5-18)30(31(36,37)38,32(39,40)41)50-16-23-24(34)2-1-3-25(23)35/h1-11,14H,12-13,15-17H2,(H2,42,43,45,47)/t29-/m0/s1 KBTAUWSUCHXJMA-LJAQVGFWSA-N 253249 US9458171, 209 Nuclear receptor ROR-gamma [262-507] 264 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253249 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253249&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217695 346547614 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440751 COC(=O)N1CCC(C1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccccc1 InChI=1S/C28H23F8NO5S/c1-41-24(38)37-15-14-25(17-37,43(39,40)20-6-3-2-4-7-20)18-10-12-19(13-11-18)26(27(31,32)33,28(34,35)36)42-16-21-22(29)8-5-9-23(21)30/h2-13H,14-17H2,1H3 DTRHJSKHNGYSQT-UHFFFAOYSA-N 253250 US9458171, 210 Nuclear receptor ROR-gamma [262-507] 216 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253250 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253250&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217696 346547615 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440752 COC(=O)N1CCC(C1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H22F9NO5S/c1-42-24(39)38-14-13-25(16-38,44(40,41)20-11-9-19(29)10-12-20)17-5-7-18(8-6-17)26(27(32,33)34,28(35,36)37)43-15-21-22(30)3-2-4-23(21)31/h2-12H,13-16H2,1H3 OJBRTFLFQNWABZ-UHFFFAOYSA-N 253251 US9458171, 211 Nuclear receptor ROR-gamma [262-507] 75 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253251 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253251&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217697 346547616 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440754 CC(C)(C)OC(=O)N1CCC(C1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccccc1 InChI=1S/C31H29F8NO5S/c1-27(2,3)45-26(41)40-17-16-28(19-40,46(42,43)22-8-5-4-6-9-22)20-12-14-21(15-13-20)29(30(34,35)36,31(37,38)39)44-18-23-24(32)10-7-11-25(23)33/h4-15H,16-19H2,1-3H3 BWRYBGPLJSGTBO-UHFFFAOYSA-N 253253 US9458171, 213 Nuclear receptor ROR-gamma [262-507] 87 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253253 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253253&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217699 346547618 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440755 CC(C)(C)OC(=O)N1CCC(C1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C31H28F9NO5S/c1-27(2,3)46-26(42)41-16-15-28(18-41,47(43,44)22-13-11-21(32)12-14-22)19-7-9-20(10-8-19)29(30(35,36)37,31(38,39)40)45-17-23-24(33)5-4-6-25(23)34/h4-14H,15-18H2,1-3H3 BPQXFLXFTOEETI-UHFFFAOYSA-N 253254 US9458171, 214 Nuclear receptor ROR-gamma [262-507] 32 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253254 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253254&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118208062 346547619 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440756 CC(C)COC(=O)N1CCC(C1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C31H28F9NO5S/c1-19(2)16-45-27(42)41-15-14-28(18-41,47(43,44)23-12-10-22(32)11-13-23)20-6-8-21(9-7-20)29(30(35,36)37,31(38,39)40)46-17-24-25(33)4-3-5-26(24)34/h3-13,19H,14-18H2,1-2H3 XZKHITUXAFVRPS-UHFFFAOYSA-N 253255 US9458171, 215 Nuclear receptor ROR-gamma [262-507] 292 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253255 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253255&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217700 346547620 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440757 CCNC(=O)N1CCC(C1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccccc1 InChI=1S/C29H26F8N2O4S/c1-2-38-25(40)39-16-15-26(18-39,44(41,42)21-7-4-3-5-8-21)19-11-13-20(14-12-19)27(28(32,33)34,29(35,36)37)43-17-22-23(30)9-6-10-24(22)31/h3-14H,2,15-18H2,1H3,(H,38,40) YJNZOUBBDBUMRA-UHFFFAOYSA-N 253256 US9458171, 216 Nuclear receptor ROR-gamma [262-507] 128 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253256 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253256&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217701 346547621 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440758 CCNC(=O)N1CCC(C1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C29H25F9N2O4S/c1-2-39-25(41)40-15-14-26(17-40,45(42,43)21-12-10-20(30)11-13-21)18-6-8-19(9-7-18)27(28(33,34)35,29(36,37)38)44-16-22-23(31)4-3-5-24(22)32/h3-13H,2,14-17H2,1H3,(H,39,41) ICTPJTLANKUZHK-UHFFFAOYSA-N 253257 US9458171, 217 Nuclear receptor ROR-gamma [262-507] 194 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253257 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253257&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217702 346547622 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440759 CC(C)(C)NC(=O)N1CCC(C1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccccc1 InChI=1S/C31H30F8N2O4S/c1-27(2,3)40-26(42)41-17-16-28(19-41,46(43,44)22-8-5-4-6-9-22)20-12-14-21(15-13-20)29(30(34,35)36,31(37,38)39)45-18-23-24(32)10-7-11-25(23)33/h4-15H,16-19H2,1-3H3,(H,40,42) FWIMTKBBPNMRLP-UHFFFAOYSA-N 253258 US9458171, 218 Nuclear receptor ROR-gamma [262-507] 116 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253258 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253258&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217703 346547623 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440760 CC(C)(C)NC(=O)N1CCC(C1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C31H29F9N2O4S/c1-27(2,3)41-26(43)42-16-15-28(18-42,47(44,45)22-13-11-21(32)12-14-22)19-7-9-20(10-8-19)29(30(35,36)37,31(38,39)40)46-17-23-24(33)5-4-6-25(23)34/h4-14H,15-18H2,1-3H3,(H,41,43) ZZXVQBPLIWWWRX-UHFFFAOYSA-N 253259 US9458171, 219 Nuclear receptor ROR-gamma [262-507] 96 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253259 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253259&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217704 346547624 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440761 CCOC(=O)CNC(=O)N1CCC(C1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C31H27F9N2O6S/c1-2-47-26(43)16-41-27(44)42-15-14-28(18-42,49(45,46)22-12-10-21(32)11-13-22)19-6-8-20(9-7-19)29(30(35,36)37,31(38,39)40)48-17-23-24(33)4-3-5-25(23)34/h3-13H,2,14-18H2,1H3,(H,41,44) UWVLZOODTWXTGD-UHFFFAOYSA-N 253260 US9458171, 220 Nuclear receptor ROR-gamma [262-507] 34 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253260 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253260&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217705 346547625 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440762 OC(=O)[C@H]1CC[C@@H](CC1)NC(=O)N1CC[C@](C1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C34H31F9N2O6S/c35-23-10-14-25(15-11-23)52(49,50)31(16-17-45(19-31)30(48)44-24-12-4-20(5-13-24)29(46)47)21-6-8-22(9-7-21)32(33(38,39)40,34(41,42)43)51-18-26-27(36)2-1-3-28(26)37/h1-3,6-11,14-15,20,24H,4-5,12-13,16-19H2,(H,44,48)(H,46,47)/t20-,24-,31-/m0/s1 TTZLFZOBZKXXCO-FHJUHCGMSA-N 253261 US9458171, 221 Nuclear receptor ROR-gamma [262-507] 133 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253261 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253261&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217706 346547626 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440763 OC(=O)[C@@H]1CC[C@@H](CC1)NC(=O)N1CC[C@](C1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C34H31F9N2O6S/c35-23-10-14-25(15-11-23)52(49,50)31(16-17-45(19-31)30(48)44-24-12-4-20(5-13-24)29(46)47)21-6-8-22(9-7-21)32(33(38,39)40,34(41,42)43)51-18-26-27(36)2-1-3-28(26)37/h1-3,6-11,14-15,20,24H,4-5,12-13,16-19H2,(H,44,48)(H,46,47)/t20-,24+,31-/m0/s1 TTZLFZOBZKXXCO-BZJRYSCWSA-N 253262 US9458171, 222 Nuclear receptor ROR-gamma [262-507] 44 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253262 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253262&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217706 346547627 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440764 Fc1ccc(cc1)S(=O)(=O)C1(CCN(C1)C(=O)Nc1ccccc1)c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F InChI=1S/C33H25F9N2O4S/c34-23-13-15-25(16-14-23)49(46,47)30(17-18-44(20-30)29(45)43-24-5-2-1-3-6-24)21-9-11-22(12-10-21)31(32(37,38)39,33(40,41)42)48-19-26-27(35)7-4-8-28(26)36/h1-16H,17-20H2,(H,43,45) LMVBSKHDYNMZOY-UHFFFAOYSA-N 253263 US9458171, 223 Nuclear receptor ROR-gamma [262-507] 155 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253263 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253263&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217707 346547628 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440765 Fc1ccc(cc1)S(=O)(=O)[C@]1(CCN(C1)C(=O)Nc1ccncc1)c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F InChI=1S/C32H24F9N3O4S/c33-22-8-10-24(11-9-22)49(46,47)29(14-17-44(19-29)28(45)43-23-12-15-42-16-13-23)20-4-6-21(7-5-20)30(31(36,37)38,32(39,40)41)48-18-25-26(34)2-1-3-27(25)35/h1-13,15-16H,14,17-19H2,(H,42,43,45)/t29-/m0/s1 SSKTTWGVMRGNEM-LJAQVGFWSA-N 253264 US9458171, 224 Nuclear receptor ROR-gamma [262-507] 18 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253264 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253264&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217708 346547629 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440766 CN(C)c1ccc(NC(=O)N2CCC(C2)(c2ccc(cc2)C(OCc2c(F)cccc2F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c2ccc(F)cc2)cc1 InChI=1S/C35H30F9N3O4S/c1-46(2)26-14-12-25(13-15-26)45-31(48)47-19-18-32(21-47,52(49,50)27-16-10-24(36)11-17-27)22-6-8-23(9-7-22)33(34(39,40)41,35(42,43)44)51-20-28-29(37)4-3-5-30(28)38/h3-17H,18-21H2,1-2H3,(H,45,48) YWIZUAXTBABDIF-UHFFFAOYSA-N 253265 US9458171, 225 Nuclear receptor ROR-gamma [262-507] 2558 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253265 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253265&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217710 346547630 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440767 Fc1ccc(cc1)S(=O)(=O)C1(CCN(C1)C(=O)NCc1ccccc1)c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F InChI=1S/C34H27F9N2O4S/c35-25-13-15-26(16-14-25)50(47,48)31(17-18-45(21-31)30(46)44-19-22-5-2-1-3-6-22)23-9-11-24(12-10-23)32(33(38,39)40,34(41,42)43)49-20-27-28(36)7-4-8-29(27)37/h1-16H,17-21H2,(H,44,46) XSAJSPRBRBUDDU-UHFFFAOYSA-N 253266 US9458171, 226 Nuclear receptor ROR-gamma [262-507] 394 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253266 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253266&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217709 346547631 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440768 OC(=O)C1CN(C1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C31H25F9N2O6S/c32-21-8-10-22(11-9-21)49(46,47)28(12-13-41(17-28)27(45)42-14-18(15-42)26(43)44)19-4-6-20(7-5-19)29(30(35,36)37,31(38,39)40)48-16-23-24(33)2-1-3-25(23)34/h1-11,18H,12-17H2,(H,43,44)/t28-/m0/s1 XOSAIXZIIRSCKP-NDEPHWFRSA-N 253267 US9458171, 227 Nuclear receptor ROR-gamma [262-507] 89 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253267 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253267&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217711 346547632 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440769 OC(=O)C1CCN(C1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C32H27F9N2O6S/c33-22-8-10-23(11-9-22)50(47,48)29(13-15-43(18-29)28(46)42-14-12-19(16-42)27(44)45)20-4-6-21(7-5-20)30(31(36,37)38,32(39,40)41)49-17-24-25(34)2-1-3-26(24)35/h1-11,19H,12-18H2,(H,44,45)/t19?,29-/m0/s1 ZZGZDPKJUDQJEO-NEFVBLPJSA-N 253268 US9458171, 228 Nuclear receptor ROR-gamma [262-507] 65 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253268 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253268&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217713 346547633 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440770 OC(=O)[C@@H]1CCN(C1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C32H27F9N2O6S/c33-22-8-10-23(11-9-22)50(47,48)29(13-15-43(18-29)28(46)42-14-12-19(16-42)27(44)45)20-4-6-21(7-5-20)30(31(36,37)38,32(39,40)41)49-17-24-25(34)2-1-3-26(24)35/h1-11,19H,12-18H2,(H,44,45)/t19-,29+/m1/s1 ZZGZDPKJUDQJEO-XBBWARJSSA-N 253269 US9458171, 229 Nuclear receptor ROR-gamma [262-507] 47 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253269 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253269&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217712 346547634 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440771 OC(=O)[C@H]1CCN(C1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C32H27F9N2O6S/c33-22-8-10-23(11-9-22)50(47,48)29(13-15-43(18-29)28(46)42-14-12-19(16-42)27(44)45)20-4-6-21(7-5-20)30(31(36,37)38,32(39,40)41)49-17-24-25(34)2-1-3-26(24)35/h1-11,19H,12-18H2,(H,44,45)/t19-,29-/m0/s1 ZZGZDPKJUDQJEO-SLQAJWMNSA-N 253270 US9458171, 230 Nuclear receptor ROR-gamma [262-507] 12 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253270 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253270&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 91820655 346547635 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440772 Fc1ccc(cc1)S(=O)(=O)[C@]1(CCN(C1)C(=O)N1CC[C@H](C1)C#N)c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F InChI=1S/C32H26F9N3O4S/c33-23-8-10-24(11-9-23)49(46,47)29(13-15-44(19-29)28(45)43-14-12-20(16-42)17-43)21-4-6-22(7-5-21)30(31(36,37)38,32(39,40)41)48-18-25-26(34)2-1-3-27(25)35/h1-11,20H,12-15,17-19H2/t20-,29-/m0/s1 ULWFIWXDJILZFM-WRONEBCDSA-N 253271 US9458171, 231 Nuclear receptor ROR-gamma [262-507] 23 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253271 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253271&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217714 346547636 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440773 Fc1ccc(cc1)S(=O)(=O)[C@]1(CCN(C1)C(=O)N1CC[C@@H](C1)C#N)c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F InChI=1S/C32H26F9N3O4S/c33-23-8-10-24(11-9-23)49(46,47)29(13-15-44(19-29)28(45)43-14-12-20(16-42)17-43)21-4-6-22(7-5-21)30(31(36,37)38,32(39,40)41)48-18-25-26(34)2-1-3-27(25)35/h1-11,20H,12-15,17-19H2/t20-,29+/m1/s1 ULWFIWXDJILZFM-OLILMLBXSA-N 253272 US9458171, 232 Nuclear receptor ROR-gamma [262-507] 30 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253272 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253272&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217715 346547637 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440774 OC(=O)C[C@@H]1CCN(C1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C33H29F9N2O6S/c34-23-8-10-24(11-9-23)51(48,49)30(13-15-44(19-30)29(47)43-14-12-20(17-43)16-28(45)46)21-4-6-22(7-5-21)31(32(37,38)39,33(40,41)42)50-18-25-26(35)2-1-3-27(25)36/h1-11,20H,12-19H2,(H,45,46)/t20-,30-/m0/s1 HLABURDNCHFIPO-WRGVRERRSA-N 253273 US9458171, 233 Nuclear receptor ROR-gamma [262-507] 39 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253273 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253273&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118218264 346547638 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440775 OC(=O)C[C@H]1CCN(C1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C33H29F9N2O6S/c34-23-8-10-24(11-9-23)51(48,49)30(13-15-44(19-30)29(47)43-14-12-20(17-43)16-28(45)46)21-4-6-22(7-5-21)31(32(37,38)39,33(40,41)42)50-18-25-26(35)2-1-3-27(25)36/h1-11,20H,12-19H2,(H,45,46)/t20-,30+/m1/s1 HLABURDNCHFIPO-KEEVHDRGSA-N 253274 US9458171, 234 Nuclear receptor ROR-gamma [262-507] 46 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253274 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253274&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217716 346547639 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440776 Fc1ccc(cc1)S(=O)(=O)[C@]1(CCN(C1)C(=O)N1CCC(C1)c1cccnc1)c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F InChI=1S/C36H30F9N3O4S/c37-27-10-12-28(13-11-27)53(50,51)33(15-18-48(22-33)32(49)47-17-14-24(20-47)23-3-2-16-46-19-23)25-6-8-26(9-7-25)34(35(40,41)42,36(43,44)45)52-21-29-30(38)4-1-5-31(29)39/h1-13,16,19,24H,14-15,17-18,20-22H2/t24?,33-/m0/s1 PMUBNPKXRWMLNB-RULBIBMZSA-N 253275 US9458171, 235 Nuclear receptor ROR-gamma [262-507] 66 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253275 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253275&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217719 346547640 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440777 Fc1ccc(cc1)S(=O)(=O)[C@]1(CCN(C1)C(=O)N1CCC(C1)c1ccncc1)c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F InChI=1S/C36H30F9N3O4S/c37-27-8-10-28(11-9-27)53(50,51)33(15-19-48(22-33)32(49)47-18-14-24(20-47)23-12-16-46-17-13-23)25-4-6-26(7-5-25)34(35(40,41)42,36(43,44)45)52-21-29-30(38)2-1-3-31(29)39/h1-13,16-17,24H,14-15,18-22H2/t24?,33-/m0/s1 RRAZNWKPVHYMBW-RULBIBMZSA-N 253276 US9458171, 236 Nuclear receptor ROR-gamma [262-507] 32 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253276 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253276&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217717 346547641 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440778 Fc1ccc(cc1)S(=O)(=O)[C@]1(CCN(C1)C(=O)N1CCC2(C1)NC(=O)NC2=O)c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F InChI=1S/C33H27F9N4O6S/c34-21-8-10-22(11-9-21)53(50,51)30(13-15-46(18-30)28(49)45-14-12-29(17-45)26(47)43-27(48)44-29)19-4-6-20(7-5-19)31(32(37,38)39,33(40,41)42)52-16-23-24(35)2-1-3-25(23)36/h1-11H,12-18H2,(H2,43,44,47,48)/t29?,30-/m0/s1 FBURFVDLCNZTCT-ZSXSBBPPSA-N 253277 US9458171, 237 Nuclear receptor ROR-gamma [262-507] 31 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253277 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253277&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217720 346547642 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440779 CN1C[C@H]2CN(C[C@H]2C1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C34H32F9N3O4S/c1-44-15-21-17-46(18-22(21)16-44)30(47)45-14-13-31(20-45,51(48,49)26-11-9-25(35)10-12-26)23-5-7-24(8-6-23)32(33(38,39)40,34(41,42)43)50-19-27-28(36)3-2-4-29(27)37/h2-12,21-22H,13-20H2,1H3/t21-,22+,31-/m0/s1 NNGHIUHTOVALLE-WPHQEQLXSA-N 253278 US9458171, 238 Nuclear receptor ROR-gamma [262-507] 378 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253278 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253278&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217725 346547643 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440780 Fc1ccc(cc1)S(=O)(=O)[C@]1(CCN(C1)C(=O)N1CCCCC1)c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F InChI=1S/C32H29F9N2O4S/c33-23-11-13-24(14-12-23)48(45,46)29(15-18-43(20-29)28(44)42-16-2-1-3-17-42)21-7-9-22(10-8-21)30(31(36,37)38,32(39,40)41)47-19-25-26(34)5-4-6-27(25)35/h4-14H,1-3,15-20H2/t29-/m0/s1 HJFJDWPWHIDMLZ-LJAQVGFWSA-N 253279 US9458171, 239 Nuclear receptor ROR-gamma [262-507] 164 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253279 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253279&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217727 346547644 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440781 O[C@@H]1CCCN(C1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C32H29F9N2O5S/c33-22-10-12-24(13-11-22)49(46,47)29(14-16-43(19-29)28(45)42-15-2-3-23(44)17-42)20-6-8-21(9-7-20)30(31(36,37)38,32(39,40)41)48-18-25-26(34)4-1-5-27(25)35/h1,4-13,23,44H,2-3,14-19H2/t23-,29+/m1/s1 GUBPBPHQVHNUIN-BTYSJIOQSA-N 253280 US9458171, 240 Nuclear receptor ROR-gamma [262-507] 152 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253280 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253280&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217721 346547645 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440782 O[C@H]1CCCN(C1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C32H29F9N2O5S/c33-22-10-12-24(13-11-22)49(46,47)29(14-16-43(19-29)28(45)42-15-2-3-23(44)17-42)20-6-8-21(9-7-20)30(31(36,37)38,32(39,40)41)48-18-25-26(34)4-1-5-27(25)35/h1,4-13,23,44H,2-3,14-19H2/t23-,29-/m0/s1 GUBPBPHQVHNUIN-IADCTJSHSA-N 253281 US9458171, 241 Nuclear receptor ROR-gamma [262-507] 262 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253281 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253281&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217723 346547646 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440783 OC[C@@H]1CCCN(C1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C33H31F9N2O5S/c34-24-10-12-25(13-11-24)50(47,48)30(14-16-44(20-30)29(46)43-15-2-3-21(17-43)18-45)22-6-8-23(9-7-22)31(32(37,38)39,33(40,41)42)49-19-26-27(35)4-1-5-28(26)36/h1,4-13,21,45H,2-3,14-20H2/t21-,30+/m1/s1 ZQDREMGGQUDELA-DFXYEROKSA-N 253282 US9458171, 242 Nuclear receptor ROR-gamma [262-507] 46 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253282 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253282&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217722 346547647 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440784 OC[C@H]1CCCN(C1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C33H31F9N2O5S/c34-24-10-12-25(13-11-24)50(47,48)30(14-16-44(20-30)29(46)43-15-2-3-21(17-43)18-45)22-6-8-23(9-7-22)31(32(37,38)39,33(40,41)42)49-19-26-27(35)4-1-5-28(26)36/h1,4-13,21,45H,2-3,14-20H2/t21-,30-/m0/s1 ZQDREMGGQUDELA-JRPXNJEYSA-N 253283 US9458171, 243 Nuclear receptor ROR-gamma [262-507] 52 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253283 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253283&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217724 346547648 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440785 OC(=O)C1CCCN(C1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C33H29F9N2O6S/c34-23-10-12-24(13-11-23)51(48,49)30(14-16-44(19-30)29(47)43-15-2-3-20(17-43)28(45)46)21-6-8-22(9-7-21)31(32(37,38)39,33(40,41)42)50-18-25-26(35)4-1-5-27(25)36/h1,4-13,20H,2-3,14-19H2,(H,45,46)/t20?,30-/m0/s1 PLYNEFBIXJQCCJ-QOWRFBDLSA-N 253284 US9458171, 244 Nuclear receptor ROR-gamma [262-507] 107 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253284 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253284&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217729 346547649 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440786 OC(=O)[C@@H]1CCCN(C1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C33H29F9N2O6S/c34-23-10-12-24(13-11-23)51(48,49)30(14-16-44(19-30)29(47)43-15-2-3-20(17-43)28(45)46)21-6-8-22(9-7-21)31(32(37,38)39,33(40,41)42)50-18-25-26(35)4-1-5-27(25)36/h1,4-13,20H,2-3,14-19H2,(H,45,46)/t20-,30+/m1/s1 PLYNEFBIXJQCCJ-KEEVHDRGSA-N 253285 US9458171, 245 Nuclear receptor ROR-gamma [262-507] 144 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253285 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253285&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217726 346547650 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440787 OC(=O)[C@H]1CCCN(C1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C33H29F9N2O6S/c34-23-10-12-24(13-11-23)51(48,49)30(14-16-44(19-30)29(47)43-15-2-3-20(17-43)28(45)46)21-6-8-22(9-7-21)31(32(37,38)39,33(40,41)42)50-18-25-26(35)4-1-5-27(25)36/h1,4-13,20H,2-3,14-19H2,(H,45,46)/t20-,30-/m0/s1 PLYNEFBIXJQCCJ-WRGVRERRSA-N 253286 US9458171, 246 Nuclear receptor ROR-gamma [262-507] 90 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253286 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253286&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217728 346547651 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440788 OC1CCN(CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C32H29F9N2O5S/c33-22-8-10-24(11-9-22)49(46,47)29(14-17-43(19-29)28(45)42-15-12-23(44)13-16-42)20-4-6-21(7-5-20)30(31(36,37)38,32(39,40)41)48-18-25-26(34)2-1-3-27(25)35/h1-11,23,44H,12-19H2/t29-/m0/s1 NZVVWQPWHMGBRB-LJAQVGFWSA-N 253287 US9458171, 247 Nuclear receptor ROR-gamma [262-507] 24 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253287 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253287&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217730 346547652 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440789 Fc1ccc(cc1)S(=O)(=O)[C@]1(CCN(C1)C(=O)N1CCC(CC1)C#N)c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F InChI=1S/C33H28F9N3O4S/c34-24-8-10-25(11-9-24)50(47,48)30(14-17-45(20-30)29(46)44-15-12-21(18-43)13-16-44)22-4-6-23(7-5-22)31(32(37,38)39,33(40,41)42)49-19-26-27(35)2-1-3-28(26)36/h1-11,21H,12-17,19-20H2/t30-/m0/s1 VPLIBRLVIWKYQH-PMERELPUSA-N 253288 US9458171, 248 Nuclear receptor ROR-gamma [262-507] 26 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253288 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253288&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118207821 346547653 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440790 CN(C)C1CCN(CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C34H34F9N3O4S/c1-44(2)25-14-17-45(18-15-25)30(47)46-19-16-31(21-46,51(48,49)26-12-10-24(35)11-13-26)22-6-8-23(9-7-22)32(33(38,39)40,34(41,42)43)50-20-27-28(36)4-3-5-29(27)37/h3-13,25H,14-21H2,1-2H3/t31-/m0/s1 RFLCWLLNAWLFRB-HKBQPEDESA-N 253289 US9458171, 249 Nuclear receptor ROR-gamma [262-507] 1316 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253289 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253289&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217731 346547654 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440791 OCC1CCN(CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C33H31F9N2O5S/c34-24-8-10-25(11-9-24)50(47,48)30(14-17-44(20-30)29(46)43-15-12-21(18-45)13-16-43)22-4-6-23(7-5-22)31(32(37,38)39,33(40,41)42)49-19-26-27(35)2-1-3-28(26)36/h1-11,21,45H,12-20H2/t30-/m0/s1 FYSTVXWMMBJSNJ-PMERELPUSA-N 253290 US9458171, 250 Nuclear receptor ROR-gamma [262-507] 108 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253290 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253290&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217733 346547655 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440792 OC(=O)C1CCN(CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C33H29F9N2O6S/c34-23-8-10-24(11-9-23)51(48,49)30(14-17-44(19-30)29(47)43-15-12-20(13-16-43)28(45)46)21-4-6-22(7-5-21)31(32(37,38)39,33(40,41)42)50-18-25-26(35)2-1-3-27(25)36/h1-11,20H,12-19H2,(H,45,46)/t30-/m0/s1 NQYYIADIMIOXNG-PMERELPUSA-N 253291 US9458171, 251 Nuclear receptor ROR-gamma [262-507] 48 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253291 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253291&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118208041 346547656 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440793 CNC(=O)C1CCN(CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C34H32F9N3O5S/c1-44-29(47)21-13-16-45(17-14-21)30(48)46-18-15-31(20-46,52(49,50)25-11-9-24(35)10-12-25)22-5-7-23(8-6-22)32(33(38,39)40,34(41,42)43)51-19-26-27(36)3-2-4-28(26)37/h2-12,21H,13-20H2,1H3,(H,44,47)/t31-/m0/s1 WCEUIPWUIOFPKL-HKBQPEDESA-N 253292 US9458171, 252 Nuclear receptor ROR-gamma [262-507] 80 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253292 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253292&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118218342 346547657 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440794 CN(C)C(=O)C1CCN(CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C35H34F9N3O5S/c1-45(2)30(48)22-14-17-46(18-15-22)31(49)47-19-16-32(21-47,53(50,51)26-12-10-25(36)11-13-26)23-6-8-24(9-7-23)33(34(39,40)41,35(42,43)44)52-20-27-28(37)4-3-5-29(27)38/h3-13,22H,14-21H2,1-2H3/t32-/m0/s1 XNVJUKCYMLEZOL-YTTGMZPUSA-N 253293 US9458171, 253 Nuclear receptor ROR-gamma [262-507] 787 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253293 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253293&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217732 346547658 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440795 CS(=O)(=O)NC(=O)C1CCN(CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C34H32F9N3O7S2/c1-54(49,50)44-29(47)21-13-16-45(17-14-21)30(48)46-18-15-31(20-46,55(51,52)25-11-9-24(35)10-12-25)22-5-7-23(8-6-22)32(33(38,39)40,34(41,42)43)53-19-26-27(36)3-2-4-28(26)37/h2-12,21H,13-20H2,1H3,(H,44,47)/t31-/m0/s1 ZRHGYGPDHSRLDF-HKBQPEDESA-N 253294 US9458171, 254 Nuclear receptor ROR-gamma [262-507] 172 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253294 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253294&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118218340 346547659 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440796 Fc1ccc(cc1)S(=O)(=O)[C@]1(CCN(C1)C(=O)N1CCC(CC1)C(=O)Nc1nncs1)c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F InChI=1S/C35H30F9N5O5S2/c36-24-8-10-25(11-9-24)56(52,53)32(14-17-49(19-32)31(51)48-15-12-21(13-16-48)29(50)46-30-47-45-20-55-30)22-4-6-23(7-5-22)33(34(39,40)41,35(42,43)44)54-18-26-27(37)2-1-3-28(26)38/h1-11,20-21H,12-19H2,(H,46,47,50)/t32-/m0/s1 BMESZYAECGQKET-YTTGMZPUSA-N 253295 US9458171, 255 Nuclear receptor ROR-gamma [262-507] 206 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253295 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253295&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118218341 346547660 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440797 OC(=O)CC1CCN(CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C34H31F9N2O6S/c35-24-8-10-25(11-9-24)52(49,50)31(14-17-45(20-31)30(48)44-15-12-21(13-16-44)18-29(46)47)22-4-6-23(7-5-22)32(33(38,39)40,34(41,42)43)51-19-26-27(36)2-1-3-28(26)37/h1-11,21H,12-20H2,(H,46,47)/t31-/m0/s1 SSKRDSOVHRWZND-HKBQPEDESA-N 253296 US9458171, 256 Nuclear receptor ROR-gamma [262-507] 132 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253296 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253296&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217734 346547661 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440798 Fc1ccc(cc1)S(=O)(=O)[C@]1(CCN(C1)C(=O)N1CCC(CC1)c1c[nH]cn1)c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F 253297 US9458171, 257 Nuclear receptor ROR-gamma [262-507] 67 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253297 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253297&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217736 346547662 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440799 Cn1cnnc1C1CCN(CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C35H32F9N5O4S/c1-47-21-45-46-30(47)22-13-16-48(17-14-22)31(50)49-18-15-32(20-49,54(51,52)26-11-9-25(36)10-12-26)23-5-7-24(8-6-23)33(34(39,40)41,35(42,43)44)53-19-27-28(37)3-2-4-29(27)38/h2-12,21-22H,13-20H2,1H3/t32-/m0/s1 ORERYINTVSTEIG-YTTGMZPUSA-N 253298 US9458171, 258 Nuclear receptor ROR-gamma [262-507] 710 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253298 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253298&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217735 346547663 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440800 Cc1nnc(C)n1C1CCN(CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C36H34F9N5O4S/c1-22-46-47-23(2)50(22)27-14-17-48(18-15-27)32(51)49-19-16-33(21-49,55(52,53)28-12-10-26(37)11-13-28)24-6-8-25(9-7-24)34(35(40,41)42,36(43,44)45)54-20-29-30(38)4-3-5-31(29)39/h3-13,27H,14-21H2,1-2H3/t33-/m0/s1 MITADRLQCLQETR-XIFFEERXSA-N 253299 US9458171, 259 Nuclear receptor ROR-gamma [262-507] 620 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253299 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253299&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217737 346547664 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440801 Fc1ccc(cc1)S(=O)(=O)[C@]1(CCN(C1)C(=O)N1CCC(CC1)c1nnn[nH]1)c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F 253300 US9458171, 260 Nuclear receptor ROR-gamma [262-507] 39 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253300 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253300&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118218329 346547665 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440802 CC1(O)CCN(CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C33H31F9N2O5S/c1-29(46)13-16-43(17-14-29)28(45)44-18-15-30(20-44,50(47,48)24-11-9-23(34)10-12-24)21-5-7-22(8-6-21)31(32(37,38)39,33(40,41)42)49-19-25-26(35)3-2-4-27(25)36/h2-12,46H,13-20H2,1H3/t30-/m0/s1 TWJVUGRLLPRALG-PMERELPUSA-N 253301 US9458171, 261 Nuclear receptor ROR-gamma [262-507] 44 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253301 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253301&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217738 346547666 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440803 OC1(CCN(CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1)C(F)(F)F InChI=1S/C33H28F12N2O5S/c34-22-8-10-23(11-9-22)53(50,51)28(12-15-47(19-28)27(48)46-16-13-29(49,14-17-46)31(37,38)39)20-4-6-21(7-5-20)30(32(40,41)42,33(43,44)45)52-18-24-25(35)2-1-3-26(24)36/h1-11,49H,12-19H2/t28-/m0/s1 LYFYDCNZDLPQCE-NDEPHWFRSA-N 253302 US9458171, 262 Nuclear receptor ROR-gamma [262-507] 80 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253302 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253302&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217739 346547667 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440804 OCC1(O)CCN(CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C33H31F9N2O6S/c34-23-8-10-24(11-9-23)51(48,49)30(14-17-44(19-30)28(46)43-15-12-29(47,20-45)13-16-43)21-4-6-22(7-5-21)31(32(37,38)39,33(40,41)42)50-18-25-26(35)2-1-3-27(25)36/h1-11,45,47H,12-20H2/t30-/m0/s1 FXMLQXDXQIEROZ-PMERELPUSA-N 253303 US9458171, 263 Nuclear receptor ROR-gamma [262-507] 65 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253303 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253303&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217740 346547668 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440805 CC(C)(C)OC(=O)NC1(C)CCN(CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C38H40F9N3O6S/c1-33(2,3)56-31(51)48-34(4)16-19-49(20-17-34)32(52)50-21-18-35(23-50,57(53,54)27-14-12-26(39)13-15-27)24-8-10-25(11-9-24)36(37(42,43)44,38(45,46)47)55-22-28-29(40)6-5-7-30(28)41/h5-15H,16-23H2,1-4H3,(H,48,51)/t35-/m0/s1 CZCJMISVHSEUJP-DHUJRADRSA-N 253304 US9458171, 264 Nuclear receptor ROR-gamma [262-507] 658 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253304 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253304&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118218331 346547669 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440806 CC1(N)CCN(CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C33H32F9N3O4S/c1-29(43)13-16-44(17-14-29)28(46)45-18-15-30(20-45,50(47,48)24-11-9-23(34)10-12-24)21-5-7-22(8-6-21)31(32(37,38)39,33(40,41)42)49-19-25-26(35)3-2-4-27(25)36/h2-12H,13-20,43H2,1H3/t30-/m0/s1 IBKXAVFDKHCFKC-PMERELPUSA-N 253305 US9458171, 265 Nuclear receptor ROR-gamma [262-507] 102 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253305 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253305&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217746 346547670 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440807 CC(=O)NC1(C)CCN(CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C35H34F9N3O5S/c1-22(48)45-31(2)14-17-46(18-15-31)30(49)47-19-16-32(21-47,53(50,51)26-12-10-25(36)11-13-26)23-6-8-24(9-7-23)33(34(39,40)41,35(42,43)44)52-20-27-28(37)4-3-5-29(27)38/h3-13H,14-21H2,1-2H3,(H,45,48)/t32-/m0/s1 SQUNXRLKBVIKGS-YTTGMZPUSA-N 253306 US9458171, 266 Nuclear receptor ROR-gamma [262-507] 115 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253306 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253306&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217741 346547671 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440808 CC1(CCN(CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1)NS(C)(=O)=O InChI=1S/C34H34F9N3O6S2/c1-30(44-53(2,48)49)14-17-45(18-15-30)29(47)46-19-16-31(21-46,54(50,51)25-12-10-24(35)11-13-25)22-6-8-23(9-7-22)32(33(38,39)40,34(41,42)43)52-20-26-27(36)4-3-5-28(26)37/h3-13,44H,14-21H2,1-2H3/t31-/m0/s1 RUEXFATVAPQCLO-HKBQPEDESA-N 253307 US9458171, 267 Nuclear receptor ROR-gamma [262-507] 113 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253307 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253307&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217742 346547672 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440809 CC1(CCN(CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1)C(O)=O InChI=1S/C34H31F9N2O6S/c1-30(28(46)47)13-16-44(17-14-30)29(48)45-18-15-31(20-45,52(49,50)24-11-9-23(35)10-12-24)21-5-7-22(8-6-21)32(33(38,39)40,34(41,42)43)51-19-25-26(36)3-2-4-27(25)37/h2-12H,13-20H2,1H3,(H,46,47)/t31-/m0/s1 OPHXGKAUNRAWFU-HKBQPEDESA-N 253308 US9458171, 268 Nuclear receptor ROR-gamma [262-507] 202 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253308 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253308&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217743 346547673 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440810 Fc1ccc(cc1)S(=O)(=O)[C@]1(CCN(C1)C(=O)N1CCC2(CC1)NC(=O)NC2=O)c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F InChI=1S/C34H29F9N4O6S/c35-22-8-10-23(11-9-22)54(51,52)31(14-17-47(19-31)29(50)46-15-12-30(13-16-46)27(48)44-28(49)45-30)20-4-6-21(7-5-20)32(33(38,39)40,34(41,42)43)53-18-24-25(36)2-1-3-26(24)37/h1-11H,12-19H2,(H2,44,45,48,49)/t31-/m0/s1 UAVUOTRQQDSVSN-HKBQPEDESA-N 253309 US9458171, 269 Nuclear receptor ROR-gamma [262-507] 28 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253309 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253309&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217744 346547674 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440811 OC1CCN(CC1O)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C32H29F9N2O6S/c33-21-8-10-22(11-9-21)50(47,48)29(13-15-43(18-29)28(46)42-14-12-26(44)27(45)16-42)19-4-6-20(7-5-19)30(31(36,37)38,32(39,40)41)49-17-23-24(34)2-1-3-25(23)35/h1-11,26-27,44-45H,12-18H2/t26?,27?,29-/m0/s1 HNAIYAZJZWQIJP-DMVZSUBZSA-N 253310 US9458171, 270 Nuclear receptor ROR-gamma [262-507] 111 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253310 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253310&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217745 346547675 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440812 CN1CCN(CC1)C(=O)N1CCC(C1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C32H30F9N3O4S/c1-42-15-17-43(18-16-42)28(45)44-14-13-29(20-44,49(46,47)24-11-9-23(33)10-12-24)21-5-7-22(8-6-21)30(31(36,37)38,32(39,40)41)48-19-25-26(34)3-2-4-27(25)35/h2-12H,13-20H2,1H3 NJMMFVONOYCHPO-UHFFFAOYSA-N 253311 US9458171, 271 Nuclear receptor ROR-gamma [262-507] 16 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253311 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253311&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217747 346547676 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440813 CN1CCN(CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C32H30F9N3O4S/c1-42-15-17-43(18-16-42)28(45)44-14-13-29(20-44,49(46,47)24-11-9-23(33)10-12-24)21-5-7-22(8-6-21)30(31(36,37)38,32(39,40)41)48-19-25-26(34)3-2-4-27(25)35/h2-12H,13-20H2,1H3/t29-/m0/s1 NJMMFVONOYCHPO-LJAQVGFWSA-N 253312 US9458171, 272 Nuclear receptor ROR-gamma [262-507] 44 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253312 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253312&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217748 346547677 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440814 CN1CCN(CC1)C(=O)N1CC[C@@](C1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C32H30F9N3O4S/c1-42-15-17-43(18-16-42)28(45)44-14-13-29(20-44,49(46,47)24-11-9-23(33)10-12-24)21-5-7-22(8-6-21)30(31(36,37)38,32(39,40)41)48-19-25-26(34)3-2-4-27(25)35/h2-12H,13-20H2,1H3/t29-/m1/s1 NJMMFVONOYCHPO-GDLZYMKVSA-N 253313 US9458171, 273 Nuclear receptor ROR-gamma [262-507] 58 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253313 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253313&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217749 346547678 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440815 Fc1ccc(cc1)S(=O)(=O)[C@]1(CCN(C1)C(=O)N1CCN(CC1)C1CC1)c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F InChI=1S/C34H32F9N3O4S/c35-24-8-12-26(13-9-24)51(48,49)31(14-15-46(21-31)30(47)45-18-16-44(17-19-45)25-10-11-25)22-4-6-23(7-5-22)32(33(38,39)40,34(41,42)43)50-20-27-28(36)2-1-3-29(27)37/h1-9,12-13,25H,10-11,14-21H2/t31-/m0/s1 HQPVWKHXMMLRRM-HKBQPEDESA-N 253314 US9458171, 274 Nuclear receptor ROR-gamma [262-507] 398 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253314 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253314&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217750 346547679 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440816 CC(=O)N1CCN(CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C33H30F9N3O5S/c1-21(46)43-15-17-44(18-16-43)29(47)45-14-13-30(20-45,51(48,49)25-11-9-24(34)10-12-25)22-5-7-23(8-6-22)31(32(37,38)39,33(40,41)42)50-19-26-27(35)3-2-4-28(26)36/h2-12H,13-20H2,1H3/t30-/m0/s1 JEJPPPHATFNBTE-PMERELPUSA-N 253315 US9458171, 275 Nuclear receptor ROR-gamma [262-507] 32 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253315 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253315&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217751 346547680 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440817 OC[C@@H]1CN(CCN1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C32H30F9N3O5S/c33-22-8-10-24(11-9-22)50(47,48)29(12-14-44(19-29)28(46)43-15-13-42-23(16-43)17-45)20-4-6-21(7-5-20)30(31(36,37)38,32(39,40)41)49-18-25-26(34)2-1-3-27(25)35/h1-11,23,42,45H,12-19H2/t23-,29-/m0/s1 UKKVCRPPCQSYNC-IADCTJSHSA-N 253316 US9458171, 276 Nuclear receptor ROR-gamma [262-507] 233 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253316 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253316&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217752 346547681 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440818 CC(=O)N1CCN(C[C@H]1CO)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C34H32F9N3O6S/c1-21(48)46-16-15-44(17-25(46)18-47)30(49)45-14-13-31(20-45,53(50,51)26-11-9-24(35)10-12-26)22-5-7-23(8-6-22)32(33(38,39)40,34(41,42)43)52-19-27-28(36)3-2-4-29(27)37/h2-12,25,47H,13-20H2,1H3/t25-,31-/m0/s1 OCMDDSAOJVTCTP-FKAPRUDGSA-N 253317 US9458171, 277 Nuclear receptor ROR-gamma [262-507] 75 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253317 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253317&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217753 346547682 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440819 CC(=O)N1CCN(C[C@@H]1CO)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C34H32F9N3O6S/c1-21(48)46-16-15-44(17-25(46)18-47)30(49)45-14-13-31(20-45,53(50,51)26-11-9-24(35)10-12-26)22-5-7-23(8-6-22)32(33(38,39)40,34(41,42)43)52-19-27-28(36)3-2-4-29(27)37/h2-12,25,47H,13-20H2,1H3/t25-,31+/m1/s1 OCMDDSAOJVTCTP-NJHZRGNWSA-N 253318 US9458171, 278 Nuclear receptor ROR-gamma [262-507] 65 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253318 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253318&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217755 346547683 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440820 Fc1ccc(cc1)S(=O)(=O)C1(CCN(C1)C(=O)N1CCOCC1)c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F InChI=1S/C31H27F9N2O5S/c32-22-8-10-23(11-9-22)48(44,45)28(12-13-42(19-28)27(43)41-14-16-46-17-15-41)20-4-6-21(7-5-20)29(30(35,36)37,31(38,39)40)47-18-24-25(33)2-1-3-26(24)34/h1-11H,12-19H2 AVTXZSGXHMLEBX-UHFFFAOYSA-N 253319 US9458171, 279 Nuclear receptor ROR-gamma [262-507] 95 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253319 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253319&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217754 346547684 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440821 Fc1ccc(cc1)S(=O)(=O)[C@]1(CCN(C1)C(=O)N1CCOCC1)c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F InChI=1S/C31H27F9N2O5S/c32-22-8-10-23(11-9-22)48(44,45)28(12-13-42(19-28)27(43)41-14-16-46-17-15-41)20-4-6-21(7-5-20)29(30(35,36)37,31(38,39)40)47-18-24-25(33)2-1-3-26(24)34/h1-11H,12-19H2/t28-/m0/s1 AVTXZSGXHMLEBX-NDEPHWFRSA-N 253320 US9458171, 280 Nuclear receptor ROR-gamma [262-507] 27 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253320 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253320&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217756 346547685 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440822 Fc1ccc(cc1)S(=O)(=O)[C@@]1(CCN(C1)C(=O)N1CCOCC1)c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F InChI=1S/C31H27F9N2O5S/c32-22-8-10-23(11-9-22)48(44,45)28(12-13-42(19-28)27(43)41-14-16-46-17-15-41)20-4-6-21(7-5-20)29(30(35,36)37,31(38,39)40)47-18-24-25(33)2-1-3-26(24)34/h1-11H,12-19H2/t28-/m1/s1 AVTXZSGXHMLEBX-MUUNZHRXSA-N 253321 US9458171, 281 Nuclear receptor ROR-gamma [262-507] 47 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253321 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253321&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217757 346547686 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440823 OCC1COCCN1C(=O)N1CC[C@@](C1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C32H29F9N2O6S/c33-22-8-10-24(11-9-22)50(46,47)29(12-13-42(19-29)28(45)43-14-15-48-17-23(43)16-44)20-4-6-21(7-5-20)30(31(36,37)38,32(39,40)41)49-18-25-26(34)2-1-3-27(25)35/h1-11,23,44H,12-19H2/t23?,29-/m1/s1 DVMZCZWBFXMEIG-GJQLDDCUSA-N 253322 US9458171, 282 Nuclear receptor ROR-gamma [262-507] 69 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253322 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253322&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217758 346547687 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440824 OC[C@H]1CN(CCO1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C32H29F9N2O6S/c33-22-8-10-24(11-9-22)50(46,47)29(12-13-43(19-29)28(45)42-14-15-48-23(16-42)17-44)20-4-6-21(7-5-20)30(31(36,37)38,32(39,40)41)49-18-25-26(34)2-1-3-27(25)35/h1-11,23,44H,12-19H2/t23-,29+/m1/s1 VFCCJVJDKDKWEX-BTYSJIOQSA-N 253323 US9458171, 283 Nuclear receptor ROR-gamma [262-507] 76 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253323 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253323&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217759 346547688 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440825 OC[C@@H]1CN(CCO1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C32H29F9N2O6S/c33-22-8-10-24(11-9-22)50(46,47)29(12-13-43(19-29)28(45)42-14-15-48-23(16-42)17-44)20-4-6-21(7-5-20)30(31(36,37)38,32(39,40)41)49-18-25-26(34)2-1-3-27(25)35/h1-11,23,44H,12-19H2/t23-,29-/m0/s1 VFCCJVJDKDKWEX-IADCTJSHSA-N 253324 US9458171, 284 Nuclear receptor ROR-gamma [262-507] 35 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253324 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253324&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217760 346547689 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440826 CS(=O)(=O)N1CCC(C1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccccc1 InChI=1S/C27H23F8NO5S2/c1-42(37,38)36-15-14-24(17-36,43(39,40)20-6-3-2-4-7-20)18-10-12-19(13-11-18)25(26(30,31)32,27(33,34)35)41-16-21-22(28)8-5-9-23(21)29/h2-13H,14-17H2,1H3 BILBXWRZAZSVNS-UHFFFAOYSA-N 253325 US9458171, 285 Nuclear receptor ROR-gamma [262-507] 923 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253325 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253325&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217761 346547690 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440827 COC(c1ccc(cc1)C1(CCN(C1)C(=O)C1CCN(CC1)C(C)=O)S(=O)(=O)c1ccc(F)cc1)(C(F)(F)F)C(F)(F)F InChI=1S/C28H29F7N2O5S/c1-18(38)36-14-11-19(12-15-36)24(39)37-16-13-25(17-37,43(40,41)23-9-7-22(29)8-10-23)20-3-5-21(6-4-20)26(42-2,27(30,31)32)28(33,34)35/h3-10,19H,11-17H2,1-2H3 GNWNVIZKJSOOOQ-UHFFFAOYSA-N 253326 US9458171, 286 Nuclear receptor ROR-gamma [262-507] 292 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253326 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253326&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217762 346547691 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440828 COC(c1ccc(cc1)[C@@]1(CCN(C1)C(=O)N1CCN(CC1)C(C)=O)S(=O)(=O)c1ccc(F)cc1)(C(F)(F)F)C(F)(F)F InChI=1S/C27H28F7N3O5S/c1-18(38)35-13-15-36(16-14-35)23(39)37-12-11-24(17-37,43(40,41)22-9-7-21(28)8-10-22)19-3-5-20(6-4-19)25(42-2,26(29,30)31)27(32,33)34/h3-10H,11-17H2,1-2H3/t24-/m0/s1 GIYOMXVGQGDCIB-DEOSSOPVSA-N 253327 US9458171, 287 Nuclear receptor ROR-gamma [262-507] 26 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253327 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253327&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217763 346547692 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440829 COC(c1ccc(cc1)[C@@]1(CCN(C1)C(=O)N1CCC(CC1)C(O)=O)S(=O)(=O)c1ccc(F)cc1)(C(F)(F)F)C(F)(F)F InChI=1S/C27H27F7N2O6S/c1-42-25(26(29,30)31,27(32,33)34)19-4-2-18(3-5-19)24(43(40,41)21-8-6-20(28)7-9-21)12-15-36(16-24)23(39)35-13-10-17(11-14-35)22(37)38/h2-9,17H,10-16H2,1H3,(H,37,38)/t24-/m0/s1 WAWUUBAEFFUIFT-DEOSSOPVSA-N 253328 US9458171, 288 Nuclear receptor ROR-gamma [262-507] 73 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253328 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253328&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217764 346547693 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440830 CCOC(c1ccc(cc1)[C@@]1(CCN(C1)C(=O)N1CCN(CC1)C(C)=O)S(=O)(=O)c1ccc(F)cc1)(C(F)(F)F)C(F)(F)F InChI=1S/C28H30F7N3O5S/c1-3-43-26(27(30,31)32,28(33,34)35)21-6-4-20(5-7-21)25(44(41,42)23-10-8-22(29)9-11-23)12-13-38(18-25)24(40)37-16-14-36(15-17-37)19(2)39/h4-11H,3,12-18H2,1-2H3/t25-/m0/s1 XAYTUNWJIVMROS-VWLOTQADSA-N 253329 US9458171, 289 Nuclear receptor ROR-gamma [262-507] 47 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253329 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253329&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217765 346547694 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440831 CC(=O)N1CCN(CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(OCC(F)(F)F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H27F10N3O5S/c1-18(42)39-12-14-40(15-13-39)23(43)41-11-10-24(16-41,47(44,45)22-8-6-21(29)7-9-22)19-2-4-20(5-3-19)26(27(33,34)35,28(36,37)38)46-17-25(30,31)32/h2-9H,10-17H2,1H3/t24-/m0/s1 OXESFTVHKCZSTR-DEOSSOPVSA-N 253330 US9458171, 290 Nuclear receptor ROR-gamma [262-507] 111 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253330 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253330&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118218313 346547695 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440832 COCCOC(c1ccc(cc1)[C@@]1(CCN(C1)C(=O)N1CCN(CC1)C(C)=O)S(=O)(=O)c1ccc(F)cc1)(C(F)(F)F)C(F)(F)F InChI=1S/C29H32F7N3O6S/c1-20(40)37-13-15-38(16-14-37)25(41)39-12-11-26(19-39,46(42,43)24-9-7-23(30)8-10-24)21-3-5-22(6-4-21)27(28(31,32)33,29(34,35)36)45-18-17-44-2/h3-10H,11-19H2,1-2H3/t26-/m0/s1 PSVJOJHZKMZIJP-SANMLTNESA-N 253331 US9458171, 291 Nuclear receptor ROR-gamma [262-507] 39 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253331 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253331&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217766 346547696 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440833 CC(=O)N1CCN(CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(OCC(N)=O)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H29F7N4O6S/c1-18(40)37-12-14-38(15-13-37)24(42)39-11-10-25(17-39,46(43,44)22-8-6-21(29)7-9-22)19-2-4-20(5-3-19)26(27(30,31)32,28(33,34)35)45-16-23(36)41/h2-9H,10-17H2,1H3,(H2,36,41)/t25-/m0/s1 KATBLHMZSXQSJQ-VWLOTQADSA-N 253332 US9458171, 292 Nuclear receptor ROR-gamma [262-507] 233 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253332 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253332&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217767 346547697 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440834 CC(=O)N1CCN(CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(OCC1CC1)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C30H32F7N3O5S/c1-20(41)38-14-16-39(17-15-38)26(42)40-13-12-27(19-40,46(43,44)25-10-8-24(31)9-11-25)22-4-6-23(7-5-22)28(29(32,33)34,30(35,36)37)45-18-21-2-3-21/h4-11,21H,2-3,12-19H2,1H3/t27-/m0/s1 PEOSVFRKZNPDOQ-MHZLTWQESA-N 253333 US9458171, 293 Nuclear receptor ROR-gamma [262-507] 26 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253333 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253333&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217768 346547698 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440835 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(OCC1CC1)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C31H32F7NO6S/c32-24-11-13-25(14-12-24)46(43,44)28(15-16-39(18-28)26(40)20-3-5-21(6-4-20)27(41)42)22-7-9-23(10-8-22)29(30(33,34)35,31(36,37)38)45-17-19-1-2-19/h7-14,19-21H,1-6,15-18H2,(H,41,42)/t20-,21-,28-/m0/s1 CMKVYYJUUIUKCS-CZBREUMFSA-N 253334 US9458171, 294 Nuclear receptor ROR-gamma [262-507] 25 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253334 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253334&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217769 346547699 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440836 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(OCC1CCC1)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C32H34F7NO6S/c33-25-12-14-26(15-13-25)47(44,45)29(16-17-40(19-29)27(41)21-4-6-22(7-5-21)28(42)43)23-8-10-24(11-9-23)30(31(34,35)36,32(37,38)39)46-18-20-2-1-3-20/h8-15,20-22H,1-7,16-19H2,(H,42,43)/t21-,22-,29-/m0/s1 SVXCWEQVRYRABX-SYZUXVNWSA-N 253335 US9458171, 295 Nuclear receptor ROR-gamma [262-507] 33 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253335 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253335&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217770 346547700 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440837 CC(=O)N1CCN(CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(OCC1CCCC1)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C32H36F7N3O5S/c1-22(43)40-16-18-41(19-17-40)28(44)42-15-14-29(21-42,48(45,46)27-12-10-26(33)11-13-27)24-6-8-25(9-7-24)30(31(34,35)36,32(37,38)39)47-20-23-4-2-3-5-23/h6-13,23H,2-5,14-21H2,1H3/t29-/m0/s1 FVLBERWQIPGBFE-LJAQVGFWSA-N 253336 US9458171, 296 Nuclear receptor ROR-gamma [262-507] 49 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253336 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253336&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217771 346547701 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440838 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(OCC1CCCC1)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C33H36F7NO6S/c34-26-13-15-27(16-14-26)48(45,46)30(17-18-41(20-30)28(42)22-5-7-23(8-6-22)29(43)44)24-9-11-25(12-10-24)31(32(35,36)37,33(38,39)40)47-19-21-3-1-2-4-21/h9-16,21-23H,1-8,17-20H2,(H,43,44)/t22-,23-,30-/m0/s1 PLKYVCCAKOPPGQ-ZRLASMASSA-N 253337 US9458171, 297 Nuclear receptor ROR-gamma [262-507] 96 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253337 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253337&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217772 346547702 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440839 CC(=O)N1CCN(CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(OCC1CCN(C1)C(=O)OC(C)(C)C)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C36H43F7N4O7S/c1-24(48)44-17-19-45(20-18-44)30(49)47-16-14-33(23-47,55(51,52)29-11-9-28(37)10-12-29)26-5-7-27(8-6-26)34(35(38,39)40,36(41,42)43)53-22-25-13-15-46(21-25)31(50)54-32(2,3)4/h5-12,25H,13-23H2,1-4H3/t25?,33-/m0/s1 QQYGIOQGZQIFIB-ZEWJHAJUSA-N 253338 US9458171, 298 Nuclear receptor ROR-gamma [262-507] 147 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253338 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253338&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217773 346547703 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440840 CC(=O)N1CCN(CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(OCC1CCNC1)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C31H35F7N4O5S/c1-21(43)40-14-16-41(17-15-40)27(44)42-13-11-28(20-42,48(45,46)26-8-6-25(32)7-9-26)23-2-4-24(5-3-23)29(30(33,34)35,31(36,37)38)47-19-22-10-12-39-18-22/h2-9,22,39H,10-20H2,1H3/t22?,28-/m0/s1 IPTIBIWNVMJHFZ-WNWQKLGWSA-N 253339 US9458171, 299 Nuclear receptor ROR-gamma [262-507] 1449 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253339 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253339&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217774 346547704 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440841 CC(=O)N1CCN(CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(OCC1CCCCC1)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C33H38F7N3O5S/c1-23(44)41-17-19-42(20-18-41)29(45)43-16-15-30(22-43,49(46,47)28-13-11-27(34)12-14-28)25-7-9-26(10-8-25)31(32(35,36)37,33(38,39)40)48-21-24-5-3-2-4-6-24/h7-14,24H,2-6,15-22H2,1H3/t30-/m0/s1 XEVHASXMRXANKF-PMERELPUSA-N 253340 US9458171, 300 Nuclear receptor ROR-gamma [262-507] 133 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253340 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253340&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217775 346547705 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440842 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(OCC1CCCCC1)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C34H38F7NO6S/c35-27-14-16-28(17-15-27)49(46,47)31(18-19-42(21-31)29(43)23-6-8-24(9-7-23)30(44)45)25-10-12-26(13-11-25)32(33(36,37)38,34(39,40)41)48-20-22-4-2-1-3-5-22/h10-17,22-24H,1-9,18-21H2,(H,44,45)/t23-,24-,31-/m0/s1 LNEQCJSAUMDARD-MKGJDZFWSA-N 253341 US9458171, 301 Nuclear receptor ROR-gamma [262-507] 51 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253341 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253341&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217776 346547706 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440843 CC1(COC(c2ccc(cc2)[C@@]2(CCN(C2)C(=O)[C@H]2CC[C@@H](CC2)C(O)=O)S(=O)(=O)c2ccc(F)cc2)(C(F)(F)F)C(F)(F)F)CCCCC1 InChI=1S/C35H40F7NO6S/c1-31(17-3-2-4-18-31)22-49-33(34(37,38)39,35(40,41)42)26-11-9-25(10-12-26)32(50(47,48)28-15-13-27(36)14-16-28)19-20-43(21-32)29(44)23-5-7-24(8-6-23)30(45)46/h9-16,23-24H,2-8,17-22H2,1H3,(H,45,46)/t23-,24-,32-/m0/s1 WOZXQBRMBVBXHZ-TWVHRYOLSA-N 253342 US9458171, 302 Nuclear receptor ROR-gamma [262-507] 1388 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253342 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253342&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217777 346547707 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440844 CC(=O)N1CCN(CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(OCC1CCC(O)CC1)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C33H38F7N3O6S/c1-22(44)41-16-18-42(19-17-41)29(46)43-15-14-30(21-43,50(47,48)28-12-8-26(34)9-13-28)24-4-6-25(7-5-24)31(32(35,36)37,33(38,39)40)49-20-23-2-10-27(45)11-3-23/h4-9,12-13,23,27,45H,2-3,10-11,14-21H2,1H3/t23?,27?,30-/m0/s1 YKGCDUBRROTUFB-GYTVGDFCSA-N 253343 US9458171, 303 Nuclear receptor ROR-gamma [262-507] 815 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253343 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253343&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217778 346547708 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440845 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(OCC1CCC(F)(F)CC1)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C34H36F9NO6S/c35-26-9-11-27(12-10-26)51(48,49)30(17-18-44(20-30)28(45)22-1-3-23(4-2-22)29(46)47)24-5-7-25(8-6-24)32(33(38,39)40,34(41,42)43)50-19-21-13-15-31(36,37)16-14-21/h5-12,21-23H,1-4,13-20H2,(H,46,47)/t22-,23-,30-/m0/s1 SLSWOTVFVMFSKD-ZRLASMASSA-N 253344 US9458171, 304 Nuclear receptor ROR-gamma [262-507] 231 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253344 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253344&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217779 346547709 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440753 CC(C)OC(=O)N1CCC(C1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C30H26F9NO5S/c1-18(2)45-26(41)40-15-14-27(17-40,46(42,43)22-12-10-21(31)11-13-22)19-6-8-20(9-7-19)28(29(34,35)36,30(37,38)39)44-16-23-24(32)4-3-5-25(23)33/h3-13,18H,14-17H2,1-2H3 MTONLKUQYTWONS-UHFFFAOYSA-N 253252 US9458171, 212 Nuclear receptor ROR-gamma [262-507] 119 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253252 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253252&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217698 346547617 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440846 CC(=O)N1CCN(CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(OCC1CCOCC1)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C32H36F7N3O6S/c1-22(43)40-14-16-41(17-15-40)28(44)42-13-12-29(21-42,49(45,46)27-8-6-26(33)7-9-27)24-2-4-25(5-3-24)30(31(34,35)36,32(37,38)39)48-20-23-10-18-47-19-11-23/h2-9,23H,10-21H2,1H3/t29-/m0/s1 JWGFJBWFKJAWRG-LJAQVGFWSA-N 253345 US9458171, 305 Nuclear receptor ROR-gamma [262-507] 54 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253345 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253345&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217780 346547710 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440847 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(OCC1CCOCC1)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C33H36F7NO7S/c34-26-9-11-27(12-10-26)49(45,46)30(15-16-41(20-30)28(42)22-1-3-23(4-2-22)29(43)44)24-5-7-25(8-6-24)31(32(35,36)37,33(38,39)40)48-19-21-13-17-47-18-14-21/h5-12,21-23H,1-4,13-20H2,(H,43,44)/t22-,23-,30-/m0/s1 SPAXCDRHZZTIMR-ZRLASMASSA-N 253346 US9458171, 306 Nuclear receptor ROR-gamma [262-507] 279 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253346 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253346&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217781 346547711 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440848 CC(=O)N1CCN(CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(OCC1CC2CCC1C2)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C34H38F7N3O5S/c1-22(45)42-14-16-43(17-15-42)30(46)44-13-12-31(21-44,50(47,48)29-10-8-28(35)9-11-29)26-4-6-27(7-5-26)32(33(36,37)38,34(39,40)41)49-20-25-19-23-2-3-24(25)18-23/h4-11,23-25H,2-3,12-21H2,1H3/t23?,24?,25?,31-/m0/s1 UVYFFYDOQZKDAI-VOMPLSNASA-N 253347 US9458171, 307 Nuclear receptor ROR-gamma [262-507] 99 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253347 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253347&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217782 346547712 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440849 CC(C)OC(c1ccc(cc1)[C@@]1(CCN(C1)C(=O)N1CCN(CC1)C(C)=O)S(=O)(=O)c1ccc(F)cc1)(C(F)(F)F)C(F)(F)F InChI=1S/C29H32F7N3O5S/c1-19(2)44-27(28(31,32)33,29(34,35)36)22-6-4-21(5-7-22)26(45(42,43)24-10-8-23(30)9-11-24)12-13-39(18-26)25(41)38-16-14-37(15-17-38)20(3)40/h4-11,19H,12-18H2,1-3H3/t26-/m0/s1 CESLHKAEVSNDCC-SANMLTNESA-N 253348 US9458171, 308 Nuclear receptor ROR-gamma [262-507] 39 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253348 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253348&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217783 346547713 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440850 CC(=O)N1CCN(CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(OC1CCCC1)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C31H34F7N3O5S/c1-21(42)39-16-18-40(19-17-39)27(43)41-15-14-28(20-41,47(44,45)26-12-10-24(32)11-13-26)22-6-8-23(9-7-22)29(30(33,34)35,31(36,37)38)46-25-4-2-3-5-25/h6-13,25H,2-5,14-20H2,1H3/t28-/m0/s1 BGNBJDHZVLSECC-NDEPHWFRSA-N 253349 US9458171, 309 Nuclear receptor ROR-gamma [262-507] 38 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253349 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253349&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217784 346547714 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440851 CC(=O)N1CCN(CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(OC1CCOCC1)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C31H34F7N3O6S/c1-21(42)39-14-16-40(17-15-39)27(43)41-13-12-28(20-41,48(44,45)26-8-6-24(32)7-9-26)22-2-4-23(5-3-22)29(30(33,34)35,31(36,37)38)47-25-10-18-46-19-11-25/h2-9,25H,10-20H2,1H3/t28-/m0/s1 YMEFRYPAAGBVAA-NDEPHWFRSA-N 253350 US9458171, 310 Nuclear receptor ROR-gamma [262-507] 51 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253350 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253350&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217785 346547715 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440852 CC(=O)N1CCN(CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(OCc1ccccc1)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C33H32F7N3O5S/c1-23(44)41-17-19-42(20-18-41)29(45)43-16-15-30(22-43,49(46,47)28-13-11-27(34)12-14-28)25-7-9-26(10-8-25)31(32(35,36)37,33(38,39)40)48-21-24-5-3-2-4-6-24/h2-14H,15-22H2,1H3/t30-/m0/s1 JWEFLGWIYBXXJM-PMERELPUSA-N 253351 US9458171, 311 Nuclear receptor ROR-gamma [262-507] 50 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253351 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253351&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217787 346547716 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440853 CC(=O)N1CCC(CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(OCc1ccccc1C#N)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C35H32F7N3O5S/c1-23(46)44-17-14-24(15-18-44)31(47)45-19-16-32(22-45,51(48,49)30-12-10-29(36)11-13-30)27-6-8-28(9-7-27)33(34(37,38)39,35(40,41)42)50-21-26-5-3-2-4-25(26)20-43/h2-13,24H,14-19,21-22H2,1H3/t32-/m0/s1 WIEUNNJBHDQIHS-YTTGMZPUSA-N 253352 US9458171, 312 Nuclear receptor ROR-gamma [262-507] 76 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253352 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253352&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217788 346547717 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440854 CC(=O)N1CCN(CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(OCc1ccccc1C#N)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C34H31F7N4O5S/c1-23(46)43-16-18-44(19-17-43)30(47)45-15-14-31(22-45,51(48,49)29-12-10-28(35)11-13-29)26-6-8-27(9-7-26)32(33(36,37)38,34(39,40)41)50-21-25-5-3-2-4-24(25)20-42/h2-13H,14-19,21-22H2,1H3/t31-/m0/s1 IIQMJZMUWFPOJY-HKBQPEDESA-N 253353 US9458171, 313 Nuclear receptor ROR-gamma [262-507] 121 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253353 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253353&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217786 346547718 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440855 CC(=O)N1CCN(CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(OCc1ccccc1C(F)(F)F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C34H31F10N3O5S/c1-22(48)45-16-18-46(19-17-45)29(49)47-15-14-30(21-47,53(50,51)27-12-10-26(35)11-13-27)24-6-8-25(9-7-24)31(33(39,40)41,34(42,43)44)52-20-23-4-2-3-5-28(23)32(36,37)38/h2-13H,14-21H2,1H3/t30-/m0/s1 WAMZIDQAVJMGMT-PMERELPUSA-N 253354 US9458171, 314 Nuclear receptor ROR-gamma [262-507] 78 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253354 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253354&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217789 346547719 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440856 CC(=O)N1CCN(CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(OCc1ccccc1OC(F)(F)F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C34H31F10N3O6S/c1-22(48)45-16-18-46(19-17-45)29(49)47-15-14-30(21-47,54(50,51)27-12-10-26(35)11-13-27)24-6-8-25(9-7-24)31(32(36,37)38,33(39,40)41)52-20-23-4-2-3-5-28(23)53-34(42,43)44/h2-13H,14-21H2,1H3/t30-/m0/s1 SWUAWEXSDQNHHM-PMERELPUSA-N 253355 US9458171, 315 Nuclear receptor ROR-gamma [262-507] 135 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253355 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253355&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118218343 346547720 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440857 OC(=O)C1CCN(CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(OCc1ccccc1OC(F)(F)F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C34H30F10N2O7S/c35-25-9-11-26(12-10-25)54(50,51)30(15-18-46(20-30)29(49)45-16-13-21(14-17-45)28(47)48)23-5-7-24(8-6-23)31(32(36,37)38,33(39,40)41)52-19-22-3-1-2-4-27(22)53-34(42,43)44/h1-12,21H,13-20H2,(H,47,48)/t30-/m0/s1 JDKVJXYDJXNONA-PMERELPUSA-N 253356 US9458171, 316 Nuclear receptor ROR-gamma [262-507] 47 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253356 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253356&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118218347 346547721 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440858 CC(=O)N1CCC(CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(OCc1ccccc1OC(F)(F)F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C35H32F10N2O6S/c1-22(48)46-17-14-23(15-18-46)30(49)47-19-16-31(21-47,54(50,51)28-12-10-27(36)11-13-28)25-6-8-26(9-7-25)32(33(37,38)39,34(40,41)42)52-20-24-4-2-3-5-29(24)53-35(43,44)45/h2-13,23H,14-21H2,1H3/t31-/m0/s1 AADMRFTUHJJWQK-HKBQPEDESA-N 253357 US9458171, 317 Nuclear receptor ROR-gamma [262-507] 168 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253357 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253357&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118218348 346547722 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440859 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(OCc1ccccc1OC(F)(F)F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C35H31F10NO7S/c36-26-13-15-27(16-14-26)54(50,51)31(17-18-46(20-31)29(47)21-5-7-22(8-6-21)30(48)49)24-9-11-25(12-10-24)32(33(37,38)39,34(40,41)42)52-19-23-3-1-2-4-28(23)53-35(43,44)45/h1-4,9-16,21-22H,5-8,17-20H2,(H,48,49)/t21-,22-,31-/m0/s1 UMCJFIFJTCQCOR-CYYCZYJVSA-N 253358 US9458171, 318 Nuclear receptor ROR-gamma [262-507] 72 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253358 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253358&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118218350 346547723 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440860 CC(=O)N1CCN(CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(OCc1cccc(c1)C#N)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C34H31F7N4O5S/c1-23(46)43-15-17-44(18-16-43)30(47)45-14-13-31(22-45,51(48,49)29-11-9-28(35)10-12-29)26-5-7-27(8-6-26)32(33(36,37)38,34(39,40)41)50-21-25-4-2-3-24(19-25)20-42/h2-12,19H,13-18,21-22H2,1H3/t31-/m0/s1 YWAIBAKMSZDEKJ-HKBQPEDESA-N 253359 US9458171, 319 Nuclear receptor ROR-gamma [262-507] 177 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253359 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253359&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217792 346547724 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440861 CC(=O)N1CCN(CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(OCc1ccc(F)cc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C33H30F9N3O5S/c1-21(46)43-14-16-44(17-15-43)29(47)45-13-12-30(20-45,51(48,49)27-10-8-25(34)9-11-27)23-3-5-24(6-4-23)31(32(37,38)39,33(40,41)42)50-19-22-2-7-26(35)18-28(22)36/h2-11,18H,12-17,19-20H2,1H3/t30-/m0/s1 QVTYWOQXLBYKMM-PMERELPUSA-N 253360 US9458171, 320 Nuclear receptor ROR-gamma [262-507] 263 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253360 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253360&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217796 346547725 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440862 CC(=O)N1CCN(CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(OCc1ccc(cc1F)C#N)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C34H30F8N4O5S/c1-22(47)44-14-16-45(17-15-44)30(48)46-13-12-31(21-46,52(49,50)28-10-8-27(35)9-11-28)25-4-6-26(7-5-25)32(33(37,38)39,34(40,41)42)51-20-24-3-2-23(19-43)18-29(24)36/h2-11,18H,12-17,20-21H2,1H3/t31-/m0/s1 VYKJYCXFXRIWMA-HKBQPEDESA-N 253361 US9458171, 321 Nuclear receptor ROR-gamma [262-507] 396 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253361 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253361&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217794 346547726 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440863 CC(=O)N1CCN(CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(OCc1ccc(F)cc1C#N)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C34H30F8N4O5S/c1-22(47)44-14-16-45(17-15-44)30(48)46-13-12-31(21-46,52(49,50)29-10-8-27(35)9-11-29)25-3-5-26(6-4-25)32(33(37,38)39,34(40,41)42)51-20-23-2-7-28(36)18-24(23)19-43/h2-11,18H,12-17,20-21H2,1H3/t31-/m0/s1 LZEQNVAHHXFCCI-HKBQPEDESA-N 253362 US9458171, 322 Nuclear receptor ROR-gamma [262-507] 106 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253362 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253362&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217797 346547727 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440864 COc1cc(ccc1COC(c1ccc(cc1)[C@@]1(CCN(C1)C(=O)N1CCN(CC1)C(C)=O)S(=O)(=O)c1ccc(F)cc1)(C(F)(F)F)C(F)(F)F)C#N InChI=1S/C35H33F7N4O6S/c1-23(47)44-15-17-45(18-16-44)31(48)46-14-13-32(22-46,53(49,50)29-11-9-28(36)10-12-29)26-5-7-27(8-6-26)33(34(37,38)39,35(40,41)42)52-21-25-4-3-24(20-43)19-30(25)51-2/h3-12,19H,13-18,21-22H2,1-2H3/t32-/m0/s1 WPEQRBXZEDKFOO-YTTGMZPUSA-N 253363 US9458171, 323 Nuclear receptor ROR-gamma [262-507] 383 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253363 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253363&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217800 346547728 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440865 COc1cc(ccc1COC(c1ccc(cc1)[C@@]1(CCN(C1)C(=O)N1CCN(CC1)C(C)=O)S(=O)(=O)c1ccc(F)cc1)(C(F)(F)F)C(F)(F)F)C(F)(F)F InChI=1S/C35H33F10N3O6S/c1-22(49)46-15-17-47(18-16-46)30(50)48-14-13-31(21-48,55(51,52)28-11-9-27(36)10-12-28)24-5-7-25(8-6-24)32(34(40,41)42,35(43,44)45)54-20-23-3-4-26(33(37,38)39)19-29(23)53-2/h3-12,19H,13-18,20-21H2,1-2H3/t31-/m0/s1 YTISDEJFPYIRCD-HKBQPEDESA-N 253364 US9458171, 324 Nuclear receptor ROR-gamma [262-507] 169 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253364 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253364&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118218339 346547729 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440866 CC(=O)N1CCC(CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(OCc1cc(F)ccc1C#N)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C35H31F8N3O5S/c1-22(47)45-15-12-23(13-16-45)31(48)46-17-14-32(21-46,52(49,50)30-10-8-28(36)9-11-30)26-3-5-27(6-4-26)33(34(38,39)40,35(41,42)43)51-20-25-18-29(37)7-2-24(25)19-44/h2-11,18,23H,12-17,20-21H2,1H3/t32-/m0/s1 UGAYCUJNACAIPG-YTTGMZPUSA-N 253365 US9458171, 325 Nuclear receptor ROR-gamma [262-507] 84 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253365 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253365&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217799 346547730 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440867 COc1ccc(F)cc1COC(c1ccc(cc1)[C@@]1(CCN(C1)C(=O)C1CCN(CC1)C(C)=O)S(=O)(=O)c1ccc(F)cc1)(C(F)(F)F)C(F)(F)F InChI=1S/C35H34F8N2O6S/c1-22(46)44-16-13-23(14-17-44)31(47)45-18-15-32(21-45,52(48,49)29-10-7-27(36)8-11-29)25-3-5-26(6-4-25)33(34(38,39)40,35(41,42)43)51-20-24-19-28(37)9-12-30(24)50-2/h3-12,19,23H,13-18,20-21H2,1-2H3/t32-/m0/s1 WSKBQXKGXNRHNQ-YTTGMZPUSA-N 253366 US9458171, 326 Nuclear receptor ROR-gamma [262-507] 254 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253366 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253366&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217801 346547731 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440868 COc1ccc(OC(F)(F)F)cc1COC(c1ccc(cc1)[C@@]1(CCN(C1)C(=O)C1CCN(CC1)C(C)=O)S(=O)(=O)c1ccc(F)cc1)(C(F)(F)F)C(F)(F)F InChI=1S/C36H34F10N2O7S/c1-22(49)47-16-13-23(14-17-47)31(50)48-18-15-32(21-48,56(51,52)29-10-7-27(37)8-11-29)25-3-5-26(6-4-25)33(34(38,39)40,35(41,42)43)54-20-24-19-28(55-36(44,45)46)9-12-30(24)53-2/h3-12,19,23H,13-18,20-21H2,1-2H3/t32-/m0/s1 SHURRIGGRRJZIP-YTTGMZPUSA-N 253367 US9458171, 327 Nuclear receptor ROR-gamma [262-507] 707 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253367 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253367&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217802 346547732 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440869 CC(=O)N1CCN(CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(OCc1cc(F)ccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C33H30F9N3O5S/c1-21(46)43-14-16-44(17-15-43)29(47)45-13-12-30(20-45,51(48,49)27-9-6-25(34)7-10-27)23-2-4-24(5-3-23)31(32(37,38)39,33(40,41)42)50-19-22-18-26(35)8-11-28(22)36/h2-11,18H,12-17,19-20H2,1H3/t30-/m0/s1 VSNOFJFMCCTHKO-PMERELPUSA-N 253368 US9458171, 328 Nuclear receptor ROR-gamma [262-507] 73 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253368 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253368&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217803 346547733 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440870 COc1ccc(F)cc1COC(c1ccc(cc1)[C@@]1(CCN(C1)C(=O)N1CCN(CC1)C(C)=O)S(=O)(=O)c1ccc(F)cc1)(C(F)(F)F)C(F)(F)F InChI=1S/C34H33F8N3O6S/c1-22(46)43-15-17-44(18-16-43)30(47)45-14-13-31(21-45,52(48,49)28-10-7-26(35)8-11-28)24-3-5-25(6-4-24)32(33(37,38)39,34(40,41)42)51-20-23-19-27(36)9-12-29(23)50-2/h3-12,19H,13-18,20-21H2,1-2H3/t31-/m0/s1 BEIPIFMJPBVIRZ-HKBQPEDESA-N 253369 US9458171, 329 Nuclear receptor ROR-gamma [262-507] 93 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253369 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253369&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217804 346547734 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440871 CC(=O)N1CCC(CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(OCc1c(C)cccc1C)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C36H37F7N2O5S/c1-23-5-4-6-24(2)31(23)21-50-34(35(38,39)40,36(41,42)43)28-9-7-27(8-10-28)33(51(48,49)30-13-11-29(37)12-14-30)17-20-45(22-33)32(47)26-15-18-44(19-16-26)25(3)46/h4-14,26H,15-22H2,1-3H3/t33-/m0/s1 HTTORLKYJHKSFA-XIFFEERXSA-N 253370 US9458171, 330 Nuclear receptor ROR-gamma [262-507] 188 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253370 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253370&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217805 346547735 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440872 Cc1cccc(C)c1COC(c1ccc(cc1)[C@@]1(CCN(C1)C(=O)N1CCC(CC1)C(O)=O)S(=O)(=O)c1ccc(F)cc1)(C(F)(F)F)C(F)(F)F InChI=1S/C35H35F7N2O6S/c1-22-4-3-5-23(2)29(22)20-50-33(34(37,38)39,35(40,41)42)26-8-6-25(7-9-26)32(51(48,49)28-12-10-27(36)11-13-28)16-19-44(21-32)31(47)43-17-14-24(15-18-43)30(45)46/h3-13,24H,14-21H2,1-2H3,(H,45,46)/t32-/m0/s1 FFPGJQGXXKVLRO-YTTGMZPUSA-N 253371 US9458171, 331 Nuclear receptor ROR-gamma [262-507] 75 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253371 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253371&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217806 346547736 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440873 Cc1cccc(C)c1COC(c1ccc(cc1)[C@@]1(CCN(C1)C(=O)[C@H]1CC[C@@H](CC1)C(O)=O)S(=O)(=O)c1ccc(F)cc1)(C(F)(F)F)C(F)(F)F InChI=1S/C36H36F7NO6S/c1-22-4-3-5-23(2)30(22)20-50-34(35(38,39)40,36(41,42)43)27-12-10-26(11-13-27)33(51(48,49)29-16-14-28(37)15-17-29)18-19-44(21-33)31(45)24-6-8-25(9-7-24)32(46)47/h3-5,10-17,24-25H,6-9,18-21H2,1-2H3,(H,46,47)/t24-,25-,33-/m0/s1 QDECFTZYQRFXHO-TZNXZYKKSA-N 253372 US9458171, 332 Nuclear receptor ROR-gamma [262-507] 81 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253372 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253372&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217807 346547737 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440874 CC(=O)N1CCC(CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(OCc1c(C)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C35H34F8N2O5S/c1-22-4-3-5-30(37)29(22)20-50-33(34(38,39)40,35(41,42)43)26-8-6-25(7-9-26)32(51(48,49)28-12-10-27(36)11-13-28)16-19-45(21-32)31(47)24-14-17-44(18-15-24)23(2)46/h3-13,24H,14-21H2,1-2H3/t32-/m0/s1 UTRHQJYTSQNLBO-YTTGMZPUSA-N 253373 US9458171, 333 Nuclear receptor ROR-gamma [262-507] 221 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253373 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253373&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217809 346547738 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440875 Cc1cccc(F)c1COC(c1ccc(cc1)[C@@]1(CCN(C1)C(=O)N1CCC(CC1)C(O)=O)S(=O)(=O)c1ccc(F)cc1)(C(F)(F)F)C(F)(F)F InChI=1S/C34H32F8N2O6S/c1-21-3-2-4-28(36)27(21)19-50-32(33(37,38)39,34(40,41)42)24-7-5-23(6-8-24)31(51(48,49)26-11-9-25(35)10-12-26)15-18-44(20-31)30(47)43-16-13-22(14-17-43)29(45)46/h2-12,22H,13-20H2,1H3,(H,45,46)/t31-/m0/s1 RUSYWEWAOYIIBZ-HKBQPEDESA-N 253374 US9458171, 334 Nuclear receptor ROR-gamma [262-507] 181 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253374 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253374&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217808 346547739 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440876 Cc1cccc(F)c1COC(c1ccc(cc1)[C@@]1(CCN(C1)C(=O)[C@H]1CC[C@@H](CC1)C(O)=O)S(=O)(=O)c1ccc(F)cc1)(C(F)(F)F)C(F)(F)F InChI=1S/C35H33F8NO6S/c1-21-3-2-4-29(37)28(21)19-50-33(34(38,39)40,35(41,42)43)25-11-9-24(10-12-25)32(51(48,49)27-15-13-26(36)14-16-27)17-18-44(20-32)30(45)22-5-7-23(8-6-22)31(46)47/h2-4,9-16,22-23H,5-8,17-20H2,1H3,(H,46,47)/t22-,23-,32-/m0/s1 AEIAAWBDOUMTLX-HYUGZUBYSA-N 253375 US9458171, 335 Nuclear receptor ROR-gamma [262-507] 166 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253375 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253375&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217810 346547740 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440877 CC(=O)N1CCC(CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(OCc1c(F)cccc1Cl)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C34H31ClF8N2O5S/c1-21(46)44-16-13-22(14-17-44)30(47)45-18-15-31(20-45,51(48,49)26-11-9-25(36)10-12-26)23-5-7-24(8-6-23)32(33(38,39)40,34(41,42)43)50-19-27-28(35)3-2-4-29(27)37/h2-12,22H,13-20H2,1H3/t31-/m0/s1 GKFGEGDTNFJUPQ-HKBQPEDESA-N 253376 US9458171, 336 Nuclear receptor ROR-gamma [262-507] 211 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253376 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253376&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217812 346547741 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440878 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(OCc1c(F)cccc1Cl)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C34H30ClF8NO6S/c35-27-2-1-3-28(37)26(27)18-50-32(33(38,39)40,34(41,42)43)23-10-8-22(9-11-23)31(51(48,49)25-14-12-24(36)13-15-25)16-17-44(19-31)29(45)20-4-6-21(7-5-20)30(46)47/h1-3,8-15,20-21H,4-7,16-19H2,(H,46,47)/t20-,21-,31-/m0/s1 XUEIXEHKBGZSHD-IHPVIADISA-N 253377 US9458171, 337 Nuclear receptor ROR-gamma [262-507] 54 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253377 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253377&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217811 346547742 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440879 CC(=O)N1CCC(CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(OCc1c(F)cccc1C#N)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C35H31F8N3O5S/c1-22(47)45-16-13-23(14-17-45)31(48)46-18-15-32(21-46,52(49,50)28-11-9-27(36)10-12-28)25-5-7-26(8-6-25)33(34(38,39)40,35(41,42)43)51-20-29-24(19-44)3-2-4-30(29)37/h2-12,23H,13-18,20-21H2,1H3/t32-/m0/s1 HHSIGRIRZCJEPB-YTTGMZPUSA-N 253378 US9458171, 338 Nuclear receptor ROR-gamma [262-507] 78 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253378 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253378&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217813 346547743 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440880 OC(=O)C1CCN(CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(OCc1c(F)cccc1C#N)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C34H29F8N3O6S/c35-25-8-10-26(11-9-25)52(49,50)31(14-17-45(20-31)30(48)44-15-12-21(13-16-44)29(46)47)23-4-6-24(7-5-23)32(33(37,38)39,34(40,41)42)51-19-27-22(18-43)2-1-3-28(27)36/h1-11,21H,12-17,19-20H2,(H,46,47)/t31-/m0/s1 OJSOZHZBIMYBOO-HKBQPEDESA-N 253379 US9458171, 339 Nuclear receptor ROR-gamma [262-507] 75 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253379 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253379&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217814 346547744 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440881 COc1cccc(F)c1COC(c1ccc(cc1)[C@@]1(CCN(C1)C(=O)N1CCC(CC1)C(O)=O)S(=O)(=O)c1ccc(F)cc1)(C(F)(F)F)C(F)(F)F InChI=1S/C34H32F8N2O7S/c1-50-28-4-2-3-27(36)26(28)19-51-32(33(37,38)39,34(40,41)42)23-7-5-22(6-8-23)31(52(48,49)25-11-9-24(35)10-12-25)15-18-44(20-31)30(47)43-16-13-21(14-17-43)29(45)46/h2-12,21H,13-20H2,1H3,(H,45,46)/t31-/m0/s1 LTCANAXDVYMFCL-HKBQPEDESA-N 253380 US9458171, 340 Nuclear receptor ROR-gamma [262-507] 56 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253380 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253380&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217815 346547745 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440882 COc1cccc(F)c1COC(c1ccc(cc1)[C@@]1(CCN(C1)C(=O)[C@H]1CC[C@@H](CC1)C(O)=O)S(=O)(=O)c1ccc(F)cc1)(C(F)(F)F)C(F)(F)F InChI=1S/C35H33F8NO7S/c1-50-29-4-2-3-28(37)27(29)19-51-33(34(38,39)40,35(41,42)43)24-11-9-23(10-12-24)32(52(48,49)26-15-13-25(36)14-16-26)17-18-44(20-32)30(45)21-5-7-22(8-6-21)31(46)47/h2-4,9-16,21-22H,5-8,17-20H2,1H3,(H,46,47)/t21-,22-,32-/m0/s1 NNNWKABZMXTXEL-YJRLZVGASA-N 253381 US9458171, 341 Nuclear receptor ROR-gamma [262-507] 155 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253381 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253381&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217816 346547746 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440883 COC(=O)c1cccc(F)c1COC(c1ccc(cc1)[C@@]1(CCN(C1)C(=O)C1CCN(CC1)C(C)=O)S(=O)(=O)c1ccc(F)cc1)(C(F)(F)F)C(F)(F)F InChI=1S/C36H34F8N2O7S/c1-22(47)45-17-14-23(15-18-45)31(48)46-19-16-33(21-46,54(50,51)27-12-10-26(37)11-13-27)24-6-8-25(9-7-24)34(35(39,40)41,36(42,43)44)53-20-29-28(32(49)52-2)4-3-5-30(29)38/h3-13,23H,14-21H2,1-2H3/t33-/m0/s1 CWRJYCLPWRRTHS-XIFFEERXSA-N 253382 US9458171, 342 Nuclear receptor ROR-gamma [262-507] 153 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253382 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253382&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118207986 346547747 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440884 CC(=O)N1CCC(CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(OCc1c(F)cccc1C(C)(C)O)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C37H38F8N2O6S/c1-23(48)46-18-15-24(16-19-46)32(49)47-20-17-34(22-47,54(51,52)28-13-11-27(38)12-14-28)25-7-9-26(10-8-25)35(36(40,41)42,37(43,44)45)53-21-29-30(33(2,3)50)5-4-6-31(29)39/h4-14,24,50H,15-22H2,1-3H3/t34-/m0/s1 ZDFBNZKQAVSQMH-UMSFTDKQSA-N 253383 US9458171, 343 Nuclear receptor ROR-gamma [262-507] 41 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253383 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253383&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217817 346547748 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440885 CC(=O)N1CCN(CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(OCc1c(F)cccc1C#N)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C34H30F8N4O5S/c1-22(47)44-15-17-45(18-16-44)30(48)46-14-13-31(21-46,52(49,50)27-11-9-26(35)10-12-27)24-5-7-25(8-6-24)32(33(37,38)39,34(40,41)42)51-20-28-23(19-43)3-2-4-29(28)36/h2-12H,13-18,20-21H2,1H3/t31-/m0/s1 QJQIXZIPDHUXKU-HKBQPEDESA-N 253384 US9458171, 344 Nuclear receptor ROR-gamma [262-507] 70 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253384 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253384&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search VBG 7JH2 118217818 346547749 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440886 CC(=O)N1CCN(CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(OCc1ccc(C#N)c(F)c1)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C34H30F8N4O5S/c1-22(47)44-14-16-45(17-15-44)30(48)46-13-12-31(21-46,52(49,50)28-10-8-27(35)9-11-28)25-4-6-26(7-5-25)32(33(37,38)39,34(40,41)42)51-20-23-2-3-24(19-43)29(36)18-23/h2-11,18H,12-17,20-21H2,1H3/t31-/m0/s1 SDXRTLUUZLHJRW-HKBQPEDESA-N 253385 US9458171, 345 Nuclear receptor ROR-gamma [262-507] 206 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253385 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253385&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217819 346547750 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440887 CC(=O)N1CCN(CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(OCc1ccc(F)c(c1)C#N)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C34H30F8N4O5S/c1-22(47)44-14-16-45(17-15-44)30(48)46-13-12-31(21-46,52(49,50)28-9-7-27(35)8-10-28)25-3-5-26(6-4-25)32(33(37,38)39,34(40,41)42)51-20-23-2-11-29(36)24(18-23)19-43/h2-11,18H,12-17,20-21H2,1H3/t31-/m0/s1 ONYNUCPPKZJWDJ-HKBQPEDESA-N 253386 US9458171, 346 Nuclear receptor ROR-gamma [262-507] 446 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253386 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253386&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217820 346547751 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440888 CC(=O)N1CCN(CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(OCc1c(F)cc(F)cc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C33H29F10N3O5S/c1-20(47)44-12-14-45(15-13-44)29(48)46-11-10-30(19-46,52(49,50)25-8-6-23(34)7-9-25)21-2-4-22(5-3-21)31(32(38,39)40,33(41,42)43)51-18-26-27(36)16-24(35)17-28(26)37/h2-9,16-17H,10-15,18-19H2,1H3/t30-/m0/s1 GJXPYLLXHADLPV-PMERELPUSA-N 253387 US9458171, 347 Nuclear receptor ROR-gamma [262-507] 216 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253387 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253387&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217821 346547752 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440889 CC(=O)N1CCN(CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(OCc1c(C)noc1C)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C32H33F7N4O6S/c1-20-27(21(2)49-40-20)18-48-30(31(34,35)36,32(37,38)39)24-6-4-23(5-7-24)29(50(46,47)26-10-8-25(33)9-11-26)12-13-43(19-29)28(45)42-16-14-41(15-17-42)22(3)44/h4-11H,12-19H2,1-3H3/t29-/m0/s1 OGPUHRUIEVHWNB-LJAQVGFWSA-N 253388 US9458171, 348 Nuclear receptor ROR-gamma [262-507] 96 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253388 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253388&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217822 346547753 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440890 Cc1noc(C)c1COC(c1ccc(cc1)[C@@]1(CCN(C1)C(=O)[C@H]1CC[C@@H](CC1)C(O)=O)S(=O)(=O)c1ccc(F)cc1)(C(F)(F)F)C(F)(F)F InChI=1S/C33H33F7N2O7S/c1-19-27(20(2)49-41-19)17-48-31(32(35,36)37,33(38,39)40)24-9-7-23(8-10-24)30(50(46,47)26-13-11-25(34)12-14-26)15-16-42(18-30)28(43)21-3-5-22(6-4-21)29(44)45/h7-14,21-22H,3-6,15-18H2,1-2H3,(H,44,45)/t21-,22-,30-/m0/s1 WJZVFKSDBSIGMZ-PWWNZBMUSA-N 253389 US9458171, 349 Nuclear receptor ROR-gamma [262-507] 74 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253389 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253389&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217823 346547754 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440891 CC(=O)N1CCN(CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(OCc1ccncn1)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C31H30F7N5O5S/c1-21(44)41-14-16-42(17-15-41)27(45)43-13-11-28(19-43,49(46,47)26-8-6-24(32)7-9-26)22-2-4-23(5-3-22)29(30(33,34)35,31(36,37)38)48-18-25-10-12-39-20-40-25/h2-10,12,20H,11,13-19H2,1H3/t28-/m0/s1 YFVWNOBRVDXPDM-NDEPHWFRSA-N 253390 US9458171, 350 Nuclear receptor ROR-gamma [262-507] 243 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253390 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253390&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217824 346547755 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440892 CC(=O)N1CCN(CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(OCc1ccnc(Cl)c1)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C32H30ClF7N4O5S/c1-21(45)42-14-16-43(17-15-42)28(46)44-13-11-29(20-44,50(47,48)26-8-6-25(34)7-9-26)23-2-4-24(5-3-23)30(31(35,36)37,32(38,39)40)49-19-22-10-12-41-27(33)18-22/h2-10,12,18H,11,13-17,19-20H2,1H3/t29-/m0/s1 PCOYHHFPTPPKBG-LJAQVGFWSA-N 253391 US9458171, 351 Nuclear receptor ROR-gamma [262-507] 155 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253391 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253391&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217825 346547756 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440893 CC(OC(c1ccc(cc1)[C@@]1(CCN(C1)C(=O)C1CCN(CC1)C(C)=O)S(=O)(=O)c1ccc(F)cc1)(C(F)(F)F)C(F)(F)F)c1ccccc1 InChI=1S/C35H35F7N2O5S/c1-23(25-6-4-3-5-7-25)49-33(34(37,38)39,35(40,41)42)28-10-8-27(9-11-28)32(50(47,48)30-14-12-29(36)13-15-30)18-21-44(22-32)31(46)26-16-19-43(20-17-26)24(2)45/h3-15,23,26H,16-22H2,1-2H3/t23?,32-/m0/s1 BIBVISGGSANEFW-ZXFDNSAJSA-N 253392 US9458171, 352 Nuclear receptor ROR-gamma [262-507] 220 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253392 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253392&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217826 346547757 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440894 CC(OC(c1ccc(cc1)[C@@]1(CCN(C1)C(=O)N1CCN(CC1)C(C)=O)S(=O)(=O)c1ccc(F)cc1)(C(F)(F)F)C(F)(F)F)c1ccccc1 InChI=1S/C34H34F7N3O5S/c1-23(25-6-4-3-5-7-25)49-32(33(36,37)38,34(39,40)41)27-10-8-26(9-11-27)31(50(47,48)29-14-12-28(35)13-15-29)16-17-44(22-31)30(46)43-20-18-42(19-21-43)24(2)45/h3-15,23H,16-22H2,1-2H3/t23?,31-/m0/s1 CFSXLSGMZDLAFN-HPTWYVLESA-N 253393 US9458171, 353 Nuclear receptor ROR-gamma [262-507] 187 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253393 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253393&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217830 346547758 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440895 C[C@H](OC(c1ccc(cc1)[C@@]1(CCN(C1)C(=O)[C@H]1CC[C@@H](CC1)C(O)=O)S(=O)(=O)c1ccc(F)cc1)(C(F)(F)F)C(F)(F)F)c1ccccc1 InChI=1S/C35H34F7NO6S/c1-22(23-5-3-2-4-6-23)49-33(34(37,38)39,35(40,41)42)27-13-11-26(12-14-27)32(50(47,48)29-17-15-28(36)16-18-29)19-20-43(21-32)30(44)24-7-9-25(10-8-24)31(45)46/h2-6,11-18,22,24-25H,7-10,19-21H2,1H3,(H,45,46)/t22-,24-,25-,32-/m0/s1 BISCJMCKYIZLKT-BMAJRESBSA-N 253394 US9458171, 354 Nuclear receptor ROR-gamma [262-507] 102 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253394 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253394&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217827 346547759 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440896 C[C@@H](OC(c1ccc(cc1)[C@@]1(CCN(C1)C(=O)[C@H]1CC[C@@H](CC1)C(O)=O)S(=O)(=O)c1ccc(F)cc1)(C(F)(F)F)C(F)(F)F)c1ccccc1 InChI=1S/C35H34F7NO6S/c1-22(23-5-3-2-4-6-23)49-33(34(37,38)39,35(40,41)42)27-13-11-26(12-14-27)32(50(47,48)29-17-15-28(36)16-18-29)19-20-43(21-32)30(44)24-7-9-25(10-8-24)31(45)46/h2-6,11-18,22,24-25H,7-10,19-21H2,1H3,(H,45,46)/t22-,24-,25-,32+/m1/s1 BISCJMCKYIZLKT-FUHXFKAOSA-N 253395 US9458171, 355 Nuclear receptor ROR-gamma [262-507] 46 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253395 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253395&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217828 346547760 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440897 CC(OC(c1ccc(cc1)[C@@]1(CCN(C1)C(=O)C1CCN(CC1)C(C)=O)S(=O)(=O)c1ccc(F)cc1)(C(F)(F)F)C(F)(F)F)c1c(F)cccc1F InChI=1S/C35H33F9N2O5S/c1-21(30-28(37)4-3-5-29(30)38)51-33(34(39,40)41,35(42,43)44)25-8-6-24(7-9-25)32(52(49,50)27-12-10-26(36)11-13-27)16-19-46(20-32)31(48)23-14-17-45(18-15-23)22(2)47/h3-13,21,23H,14-20H2,1-2H3/t21?,32-/m0/s1 RSBGHFHNBLJSMR-SOFIOUBHSA-N 253396 US9458171, 356 Nuclear receptor ROR-gamma [262-507] 44 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253396 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253396&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217831 346547761 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440898 CC(OC(c1ccc(cc1)[C@@]1(CCN(C1)C(=O)N1CCN(CC1)C(C)=O)S(=O)(=O)c1ccc(F)cc1)(C(F)(F)F)C(F)(F)F)C1CCCCC1 InChI=1S/C34H40F7N3O5S/c1-23(25-6-4-3-5-7-25)49-32(33(36,37)38,34(39,40)41)27-10-8-26(9-11-27)31(50(47,48)29-14-12-28(35)13-15-29)16-17-44(22-31)30(46)43-20-18-42(19-21-43)24(2)45/h8-15,23,25H,3-7,16-22H2,1-2H3/t23?,31-/m0/s1 JVADCFYYGMOJRI-HPTWYVLESA-N 253397 US9458171, 357 Nuclear receptor ROR-gamma [262-507] 182 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253397 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253397&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217834 346547762 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440899 CC(=O)N1CCC(CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(Oc1ccc(F)cc1)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C33H30F8N2O5S/c1-21(44)42-17-14-22(15-18-42)29(45)43-19-16-30(20-43,49(46,47)28-12-8-26(35)9-13-28)23-2-4-24(5-3-23)31(32(36,37)38,33(39,40)41)48-27-10-6-25(34)7-11-27/h2-13,22H,14-20H2,1H3/t30-/m0/s1 IHVPKNFLKUJYPL-PMERELPUSA-N 253398 US9458171, 358 Nuclear receptor ROR-gamma [262-507] 208 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253398 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253398&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217829 346547763 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440900 COc1ccc(OC(c2ccc(cc2)[C@@]2(CCN(C2)C(=O)C2CCN(CC2)C(C)=O)S(=O)(=O)c2ccc(F)cc2)(C(F)(F)F)C(F)(F)F)cc1 InChI=1S/C34H33F7N2O6S/c1-22(44)42-18-15-23(16-19-42)30(45)43-20-17-31(21-43,50(46,47)29-13-7-26(35)8-14-29)24-3-5-25(6-4-24)32(33(36,37)38,34(39,40)41)49-28-11-9-27(48-2)10-12-28/h3-14,23H,15-21H2,1-2H3/t31-/m0/s1 RPMXVBOPIKBTPZ-HKBQPEDESA-N 253399 US9458171, 359 Nuclear receptor ROR-gamma [262-507] 295 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253399 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253399&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118218345 346547764 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440901 CC(=O)N1CCC(CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(Oc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C33H29F9N2O5S/c1-20(45)43-16-13-21(14-17-43)29(46)44-18-15-30(19-44,50(47,48)25-11-9-24(34)10-12-25)22-5-7-23(8-6-22)31(32(37,38)39,33(40,41)42)49-28-26(35)3-2-4-27(28)36/h2-12,21H,13-19H2,1H3/t30-/m0/s1 WBZCDMFXBCSEOU-PMERELPUSA-N 253400 US9458171, 360 Nuclear receptor ROR-gamma [262-507] 86 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253400 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253400&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217833 346547765 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440902 CC(=O)N1CCC(CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(Oc1cccc2ccccc12)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C37H33F7N2O5S/c1-24(47)45-20-17-26(18-21-45)33(48)46-22-19-34(23-46,52(49,50)30-15-13-29(38)14-16-30)27-9-11-28(12-10-27)35(36(39,40)41,37(42,43)44)51-32-8-4-6-25-5-2-3-7-31(25)32/h2-16,26H,17-23H2,1H3/t34-/m0/s1 QCGFUUMLVJRVFJ-UMSFTDKQSA-N 253401 US9458171, 361 Nuclear receptor ROR-gamma [262-507] 196 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253401 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253401&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217835 346547766 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440903 CCC(C)(O)c1ccc(cc1)[C@@]1(CCN(C1)C(=O)N1CCN(CC1)C(C)=O)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C27H34FN3O5S/c1-4-26(3,34)21-5-7-22(8-6-21)27(37(35,36)24-11-9-23(28)10-12-24)13-14-31(19-27)25(33)30-17-15-29(16-18-30)20(2)32/h5-12,34H,4,13-19H2,1-3H3/t26?,27-/m0/s1 VRLOOORJGKTZDY-GEVKEYJPSA-N 253402 US9458171, 362 Nuclear receptor ROR-gamma [262-507] 365 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253402 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253402&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217836 346547767 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440904 CC(=O)N1CCN(CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(C)(O)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C26H29F4N3O5S/c1-18(34)31-13-15-32(16-14-31)23(35)33-12-11-25(17-33,39(37,38)22-9-7-21(27)8-10-22)20-5-3-19(4-6-20)24(2,36)26(28,29)30/h3-10,36H,11-17H2,1-2H3/t24?,25-/m0/s1 BIWBKQPXPARRDH-BBMPLOMVSA-N 253403 US9458171, 363 Nuclear receptor ROR-gamma [262-507] 115 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253403 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253403&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217839 346547768 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440905 COC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H28F7NO5S/c1-41-25(38)19-4-2-18(3-5-19)24(37)36-15-14-26(16-36,42(39,40)22-12-10-21(29)11-13-22)20-8-6-17(7-9-20)23(27(30,31)32)28(33,34)35/h6-13,18-19,23H,2-5,14-16H2,1H3/t18-,19-,26-/m0/s1 WTJHKWLVBYRQPN-DGUDUIIESA-N 253404 US9458171, 364 Nuclear receptor ROR-gamma [262-507] 1300 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253404 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253404&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118218328 346547769 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440906 CC(=O)N1CCN(CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(C)(OCc1c(F)cccc1F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C33H33F6N3O5S/c1-22(43)40-16-18-41(19-17-40)30(44)42-15-14-32(21-42,48(45,46)26-12-10-25(34)11-13-26)24-8-6-23(7-9-24)31(2,33(37,38)39)47-20-27-28(35)4-3-5-29(27)36/h3-13H,14-21H2,1-2H3/t31?,32-/m0/s1 LHVZABULJGNHAL-JYUUXGOASA-N 253405 US9458171, 365 Nuclear receptor ROR-gamma [262-507] 79 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253405 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253405&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217840 346547770 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440907 Fc1ccc(cc1)S(=O)(=O)[C@]1(CCN(C1)C(=O)Cc1ccc(cc1)C#N)c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F InChI=1S/C35H25F9N2O4S/c36-26-12-14-27(15-13-26)51(48,49)32(16-17-46(21-32)31(47)18-22-4-6-23(19-45)7-5-22)24-8-10-25(11-9-24)33(34(39,40)41,35(42,43)44)50-20-28-29(37)2-1-3-30(28)38/h1-15H,16-18,20-21H2/t32-/m0/s1 CZYHLRGNXMPYJO-YTTGMZPUSA-N 253406 US9458171, 366 Nuclear receptor ROR-gamma [262-507] 48 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253406 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253406&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217838 346547771 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440908 Cc1cc(ccc1F)S(=O)(=O)[C@]1(CCN(Cc2ccccc2)C1)c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F InChI=1S/C27H23F8NO2S/c1-18-15-22(11-12-23(18)28)39(37,38)24(13-14-36(17-24)16-19-5-3-2-4-6-19)20-7-9-21(10-8-20)25(29,26(30,31)32)27(33,34)35/h2-12,15H,13-14,16-17H2,1H3/t24-/m0/s1 LMPXSNXRGUFDCH-DEOSSOPVSA-N 253407 US9458171, 367 Nuclear receptor ROR-gamma [262-507] 3443 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253407 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253407&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118207998 346547772 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440909 CC(=O)N1CCN(CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)c(C)c1 InChI=1S/C27H27F8N3O4S/c1-17-15-21(7-8-22(17)28)43(41,42)24(9-10-38(16-24)23(40)37-13-11-36(12-14-37)18(2)39)19-3-5-20(6-4-19)25(29,26(30,31)32)27(33,34)35/h3-8,15H,9-14,16H2,1-2H3/t24-/m0/s1 HXNZXZJWLAHFPD-DEOSSOPVSA-N 253408 US9458171, 368 Nuclear receptor ROR-gamma [262-507] 24 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253408 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253408&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118207945 346547773 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440910 CC(=O)N1CCN(CC1)C(=O)N1CC[C@@](C1)(c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)c(C)c1 InChI=1S/C27H27F8N3O4S/c1-17-15-21(7-8-22(17)28)43(41,42)24(9-10-38(16-24)23(40)37-13-11-36(12-14-37)18(2)39)19-3-5-20(6-4-19)25(29,26(30,31)32)27(33,34)35/h3-8,15H,9-14,16H2,1-2H3/t24-/m1/s1 HXNZXZJWLAHFPD-XMMPIXPASA-N 253409 US9458171, 369 Nuclear receptor ROR-gamma [262-507] 1819 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253409 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253409&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118208151 346547774 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440911 Cc1cc(ccc1F)S(=O)(=O)[C@]1(CCN(C1)C(=O)C1(O)CCC(CC1)C(O)=O)c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F InChI=1S/C28H27F8NO6S/c1-16-14-20(6-7-21(16)29)44(42,43)25(18-2-4-19(5-3-18)26(30,27(31,32)33)28(34,35)36)12-13-37(15-25)23(40)24(41)10-8-17(9-11-24)22(38)39/h2-7,14,17,41H,8-13,15H2,1H3,(H,38,39)/t17?,24?,25-/m0/s1 UETHJQAVQPVEBU-RIIRKCAYSA-N 253410 US9458171, 370 Nuclear receptor ROR-gamma [262-507] 80 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253410 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253410&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217841 346547775 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440912 Cc1cc(ccc1F)S(=O)(=O)[C@@]1(CCN(C1)C(=O)C1(O)CCC(CC1)C(O)=O)c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F InChI=1S/C28H27F8NO6S/c1-16-14-20(6-7-21(16)29)44(42,43)25(18-2-4-19(5-3-18)26(30,27(31,32)33)28(34,35)36)12-13-37(15-25)23(40)24(41)10-8-17(9-11-24)22(38)39/h2-7,14,17,41H,8-13,15H2,1H3,(H,38,39)/t17?,24?,25-/m1/s1 UETHJQAVQPVEBU-XPBUXGOKSA-N 253411 US9458171, 371 Nuclear receptor ROR-gamma [262-507] 68 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253411 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253411&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 131636475 346547776 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440913 Cc1cc(ccc1F)S(=O)(=O)[C@]1(CCN(C1)C(=O)[C@]1(C)CC[C@@H](CC1)C(O)=O)c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F InChI=1S/C29H29F8NO5S/c1-17-15-21(7-8-22(17)30)44(42,43)26(19-3-5-20(6-4-19)27(31,28(32,33)34)29(35,36)37)13-14-38(16-26)24(41)25(2)11-9-18(10-12-25)23(39)40/h3-8,15,18H,9-14,16H2,1-2H3,(H,39,40)/t18-,25+,26-/m0/s1 MZWGMEVIRXORPA-IMDCKVJKSA-N 253412 US9458171, 372 Nuclear receptor ROR-gamma [262-507] 553 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253412 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253412&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217842 346547777 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440914 Cc1cc(ccc1F)S(=O)(=O)[C@]1(CCN(C1)C(=O)[C@@]1(C)CC[C@@H](CC1)C(O)=O)c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F InChI=1S/C29H29F8NO5S/c1-17-15-21(7-8-22(17)30)44(42,43)26(19-3-5-20(6-4-19)27(31,28(32,33)34)29(35,36)37)13-14-38(16-26)24(41)25(2)11-9-18(10-12-25)23(39)40/h3-8,15,18H,9-14,16H2,1-2H3,(H,39,40)/t18-,25-,26-/m0/s1 MZWGMEVIRXORPA-ATANMQQVSA-N 253413 US9458171, 373 Nuclear receptor ROR-gamma [262-507] 61 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253413 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253413&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217842 346547778 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440915 CC[C@@]1(CC[C@@H](CC1)C(O)=O)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)c(C)c1 InChI=1S/C30H31F8NO5S/c1-3-26(12-10-19(11-13-26)24(40)41)25(42)39-15-14-27(17-39,45(43,44)22-8-9-23(31)18(2)16-22)20-4-6-21(7-5-20)28(32,29(33,34)35)30(36,37)38/h4-9,16,19H,3,10-15,17H2,1-2H3,(H,40,41)/t19-,26-,27-/m0/s1 AHXUPPRSSHLOPV-DOYMOWJKSA-N 253414 US9458171, 374 Nuclear receptor ROR-gamma [262-507] 41 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253414 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253414&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217843 346547779 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440916 Cc1cc(ccc1F)S(=O)(=O)[C@]1(CCN(C1)C(=O)[C@@]1(F)CC[C@@H](CC1)C(O)=O)c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F InChI=1S/C28H26F9NO5S/c1-16-14-20(6-7-21(16)29)44(42,43)25(18-2-4-19(5-3-18)26(31,27(32,33)34)28(35,36)37)12-13-38(15-25)23(41)24(30)10-8-17(9-11-24)22(39)40/h2-7,14,17H,8-13,15H2,1H3,(H,39,40)/t17-,24+,25-/m0/s1 QZUWMRNMYPAEKJ-AJHZIAPWSA-N 253415 US9458171, 375 Nuclear receptor ROR-gamma [262-507] 51 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253415 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253415&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217844 346547780 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440917 CCC[C@@]1(CC[C@@H](CC1)C(O)=O)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)c(C)c1 InChI=1S/C31H33F8NO5S/c1-3-12-27(13-10-20(11-14-27)25(41)42)26(43)40-16-15-28(18-40,46(44,45)23-8-9-24(32)19(2)17-23)21-4-6-22(7-5-21)29(33,30(34,35)36)31(37,38)39/h4-9,17,20H,3,10-16,18H2,1-2H3,(H,41,42)/t20-,27-,28-/m0/s1 MWBZCGSDEGSXEB-IIZLTXOPSA-N 253416 US9458171, 376 Nuclear receptor ROR-gamma [262-507] 71 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253416 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253416&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217845 346547781 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440918 Cc1cc(ccc1F)S(=O)(=O)[C@]1(CCN(C1)C(=O)[C@@]1(CC=C)CC[C@@H](CC1)C(O)=O)c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F InChI=1S/C31H31F8NO5S/c1-3-12-27(13-10-20(11-14-27)25(41)42)26(43)40-16-15-28(18-40,46(44,45)23-8-9-24(32)19(2)17-23)21-4-6-22(7-5-21)29(33,30(34,35)36)31(37,38)39/h3-9,17,20H,1,10-16,18H2,2H3,(H,41,42)/t20-,27-,28-/m0/s1 XEECDDJNDWXXCF-IIZLTXOPSA-N 253417 US9458171, 377 Nuclear receptor ROR-gamma [262-507] 69 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253417 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253417&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217846 346547782 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440919 Cc1cc(ccc1F)S(=O)(=O)[C@]1(CCN(C1)C(=O)C12CCC(CC1)(CC2)C(O)=O)c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F InChI=1S/C30H29F8NO5S/c1-18-16-21(6-7-22(18)31)45(43,44)27(19-2-4-20(5-3-19)28(32,29(33,34)35)30(36,37)38)14-15-39(17-27)23(40)25-8-11-26(12-9-25,13-10-25)24(41)42/h2-7,16H,8-15,17H2,1H3,(H,41,42)/t25?,26?,27-/m0/s1 IQRYBXXXVMYQFI-RCSZBHJWSA-N 253418 US9458171, 378 Nuclear receptor ROR-gamma [262-507] 79 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253418 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253418&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217848 346547783 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440920 Cc1cc(ccc1F)S(=O)(=O)[C@]1(CCN(C1)C(=O)C1CCS(=O)(=O)CC1)c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F InChI=1S/C26H25F8NO5S2/c1-16-14-20(6-7-21(16)27)42(39,40)23(10-11-35(15-23)22(36)17-8-12-41(37,38)13-9-17)18-2-4-19(5-3-18)24(28,25(29,30)31)26(32,33)34/h2-7,14,17H,8-13,15H2,1H3/t23-/m0/s1 ZGKKKUYNNOOVCZ-QHCPKHFHSA-N 253419 US9458171, 379 Nuclear receptor ROR-gamma [262-507] 44 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253419 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253419&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217847 346547784 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440921 Cc1cc(ccc1F)S(=O)(=O)[C@]1(CCN(C1)C(=O)C12CCC(CC1)(CO2)C(O)=O)c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F InChI=1S/C29H27F8NO6S/c1-17-14-20(6-7-21(17)30)45(42,43)26(18-2-4-19(5-3-18)27(31,28(32,33)34)29(35,36)37)12-13-38(15-26)22(39)25-10-8-24(9-11-25,16-44-25)23(40)41/h2-7,14H,8-13,15-16H2,1H3,(H,40,41)/t24?,25?,26-/m0/s1 UIHMMCPJXQYMBR-WNMGUVTHSA-N 253420 US9458171, 380 Nuclear receptor ROR-gamma [262-507] 186 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253420 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253420&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217849 346547785 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440922 Cc1cc(ccc1F)S(=O)(=O)[C@]1(CCN(C1)C(=O)C12CCC(CC1)(OC2)C(O)=O)c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F InChI=1S/C29H27F8NO6S/c1-17-14-20(6-7-21(17)30)45(42,43)26(18-2-4-19(5-3-18)27(31,28(32,33)34)29(35,36)37)12-13-38(15-26)22(39)24-8-10-25(11-9-24,23(40)41)44-16-24/h2-7,14H,8-13,15-16H2,1H3,(H,40,41)/t24?,25?,26-/m0/s1 LJRBSKVLWJILQM-WNMGUVTHSA-N 253421 US9458171, 381 Nuclear receptor ROR-gamma [262-507] 171 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253421 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253421&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217850 346547786 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440923 C[C@@]1(CC[C@@H](CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1)C(O)=O InChI=1S/C28H27F8NO5S/c1-24(23(39)40)12-10-17(11-13-24)22(38)37-15-14-25(16-37,43(41,42)21-8-6-20(29)7-9-21)18-2-4-19(5-3-18)26(30,27(31,32)33)28(34,35)36/h2-9,17H,10-16H2,1H3,(H,39,40)/t17-,24-,25-/m0/s1 GCIQMJRRIADVCD-HDBFHEOPSA-N 253422 US9458171, 382 Nuclear receptor ROR-gamma [262-507] 57 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253422 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253422&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217851 346547787 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440924 OC(=O)[C@]1(F)CC[C@@H](CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C27H24F9NO5S/c28-19-5-7-20(8-6-19)43(41,42)24(17-1-3-18(4-2-17)25(30,26(31,32)33)27(34,35)36)13-14-37(15-24)21(38)16-9-11-23(29,12-10-16)22(39)40/h1-8,16H,9-15H2,(H,39,40)/t16-,23-,24-/m0/s1 SEPMYXWLNORQTN-ZCWWJEROSA-N 253423 US9458171, 383 Nuclear receptor ROR-gamma [262-507] 1599 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253423 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253423&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217852 346547788 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440925 OC(=O)[C@H]1CC[C@](F)(CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C27H24F9NO5S/c28-19-5-7-20(8-6-19)43(41,42)24(17-1-3-18(4-2-17)25(30,26(31,32)33)27(34,35)36)13-14-37(15-24)22(40)23(29)11-9-16(10-12-23)21(38)39/h1-8,16H,9-15H2,(H,38,39)/t16-,23-,24-/m0/s1 VXQLLPVKMJJWAK-ZCWWJEROSA-N 253424 US9458171, 384 Nuclear receptor ROR-gamma [262-507] 370 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253424 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253424&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217853 346547789 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440926 OC(=O)[C@@]1(F)CC[C@@H](CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C27H24F9NO5S/c28-19-5-7-20(8-6-19)43(41,42)24(17-1-3-18(4-2-17)25(30,26(31,32)33)27(34,35)36)13-14-37(15-24)21(38)16-9-11-23(29,12-10-16)22(39)40/h1-8,16H,9-15H2,(H,39,40)/t16-,23+,24-/m0/s1 SEPMYXWLNORQTN-GHEQTVGYSA-N 253425 US9458171, 385 Nuclear receptor ROR-gamma [262-507] 24 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253425 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253425&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217852 346547790 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440927 OC(=O)[C@H]1CC[C@@](F)(CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C27H24F9NO5S/c28-19-5-7-20(8-6-19)43(41,42)24(17-1-3-18(4-2-17)25(30,26(31,32)33)27(34,35)36)13-14-37(15-24)22(40)23(29)11-9-16(10-12-23)21(38)39/h1-8,16H,9-15H2,(H,38,39)/t16-,23+,24-/m0/s1 VXQLLPVKMJJWAK-GHEQTVGYSA-N 253426 US9458171, 386 Nuclear receptor ROR-gamma [262-507] 43 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253426 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253426&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217853 346547791 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440928 CC[C@@]1(CC[C@@H](CC1)C(O)=O)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C29H29F8NO5S/c1-2-25(13-11-18(12-14-25)23(39)40)24(41)38-16-15-26(17-38,44(42,43)22-9-7-21(30)8-10-22)19-3-5-20(6-4-19)27(31,28(32,33)34)29(35,36)37/h3-10,18H,2,11-17H2,1H3,(H,39,40)/t18-,25-,26-/m0/s1 SVRMKEVXYJZNLQ-ATANMQQVSA-N 253427 US9458171, 387 Nuclear receptor ROR-gamma [262-507] 28 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253427 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253427&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217854 346547792 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440929 C[C@@]1(CCC(F)(F)CO1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C26H23F10NO4S/c1-21(10-11-23(28,29)15-41-21)20(38)37-13-12-22(14-37,42(39,40)19-8-6-18(27)7-9-19)16-2-4-17(5-3-16)24(30,25(31,32)33)26(34,35)36/h2-9H,10-15H2,1H3/t21-,22+/m1/s1 RCLNLYLUEANSTI-YADHBBJMSA-N 253428 US9458171, 388 Nuclear receptor ROR-gamma [262-507] 311 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253428 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253428&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217855 346547793 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440930 C[C@]1(CCC(F)(F)CO1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C26H23F10NO4S/c1-21(10-11-23(28,29)15-41-21)20(38)37-13-12-22(14-37,42(39,40)19-8-6-18(27)7-9-19)16-2-4-17(5-3-16)24(30,25(31,32)33)26(34,35)36/h2-9H,10-15H2,1H3/t21-,22-/m0/s1 RCLNLYLUEANSTI-VXKWHMMOSA-N 253429 US9458171, 389 Nuclear receptor ROR-gamma [262-507] 323 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253429 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253429&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217856 346547794 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440931 OC(=O)[C@H]1CC[C@@](CC=C)(CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C30H29F8NO5S/c1-2-13-26(14-11-19(12-15-26)24(40)41)25(42)39-17-16-27(18-39,45(43,44)23-9-7-22(31)8-10-23)20-3-5-21(6-4-20)28(32,29(33,34)35)30(36,37)38/h2-10,19H,1,11-18H2,(H,40,41)/t19-,26-,27-/m0/s1 ADKRMWGYXSYHFE-DOYMOWJKSA-N 253430 US9458171, 390 Nuclear receptor ROR-gamma [262-507] 80 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253430 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253430&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217857 346547795 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440932 Fc1ccc(cc1)S(=O)(=O)[C@]1(CCN(C1)C(=O)c1ccc2ncccc2c1)c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F InChI=1S/C29H20F8N2O3S/c30-22-8-10-23(11-9-22)43(41,42)26(20-4-6-21(7-5-20)27(31,28(32,33)34)29(35,36)37)13-15-39(17-26)25(40)19-3-12-24-18(16-19)2-1-14-38-24/h1-12,14,16H,13,15,17H2/t26-/m0/s1 MDBQEINWXLSXET-SANMLTNESA-N 253431 US9458171, 391 Nuclear receptor ROR-gamma [262-507] 1435 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253431 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253431&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217861 346547796 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440933 OC(=O)C12CCC(CC1)(CC2)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C29H27F8NO5S/c30-20-5-7-21(8-6-20)44(42,43)26(18-1-3-19(4-2-18)27(31,28(32,33)34)29(35,36)37)15-16-38(17-26)22(39)24-9-12-25(13-10-24,14-11-24)23(40)41/h1-8H,9-17H2,(H,40,41)/t24?,25?,26-/m0/s1 BFUUZNNTBJZLDG-WNMGUVTHSA-N 253432 US9458171, 392 Nuclear receptor ROR-gamma [262-507] 60 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253432 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253432&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217858 346547797 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440934 CCC[C@@]1(CC[C@@H](CC1)C(O)=O)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C30H31F8NO5S/c1-2-13-26(14-11-19(12-15-26)24(40)41)25(42)39-17-16-27(18-39,45(43,44)23-9-7-22(31)8-10-23)20-3-5-21(6-4-20)28(32,29(33,34)35)30(36,37)38/h3-10,19H,2,11-18H2,1H3,(H,40,41)/t19-,26-,27-/m0/s1 SJFLTEYVNDWHPL-DOYMOWJKSA-N 253433 US9458171, 393 Nuclear receptor ROR-gamma [262-507] 142 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253433 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253433&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217859 346547798 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440935 Fc1ccc(cc1)S(=O)(=O)[C@]1(CCN(C1)C(=O)c1cccc2cnccc12)c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F InChI=1S/C29H20F8N2O3S/c30-21-8-10-22(11-9-21)43(41,42)26(19-4-6-20(7-5-19)27(31,28(32,33)34)29(35,36)37)13-15-39(17-26)25(40)24-3-1-2-18-16-38-14-12-23(18)24/h1-12,14,16H,13,15,17H2/t26-/m0/s1 CRJOQSWFAMXNHK-SANMLTNESA-N 253434 US9458171, 394 Nuclear receptor ROR-gamma [262-507] 2393 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253434 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253434&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217860 346547799 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440936 Fc1ccc(cc1)S(=O)(=O)[C@]1(CCN(C1)C(=O)c1cccc2ncccc12)c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F InChI=1S/C29H20F8N2O3S/c30-20-10-12-21(13-11-20)43(41,42)26(18-6-8-19(9-7-18)27(31,28(32,33)34)29(35,36)37)14-16-39(17-26)25(40)23-3-1-5-24-22(23)4-2-15-38-24/h1-13,15H,14,16-17H2/t26-/m0/s1 MCANSXGOOJKXIF-SANMLTNESA-N 253435 US9458171, 395 Nuclear receptor ROR-gamma [262-507] 2816 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253435 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253435&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217862 346547800 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440937 CC[C@@]1(CC[C@@H](CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1)C(O)=O InChI=1S/C29H29F8NO5S/c1-2-25(24(40)41)13-11-18(12-14-25)23(39)38-16-15-26(17-38,44(42,43)22-9-7-21(30)8-10-22)19-3-5-20(6-4-19)27(31,28(32,33)34)29(35,36)37/h3-10,18H,2,11-17H2,1H3,(H,40,41)/t18-,25-,26-/m0/s1 NMDBMKMFARAOPP-ATANMQQVSA-N 253436 US9458171, 396 Nuclear receptor ROR-gamma [262-507] 171 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253436 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253436&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217863 346547801 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440938 OC(=O)C12CCC(CC1)(C2)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H25F8NO5S/c29-19-5-7-20(8-6-19)43(41,42)25(17-1-3-18(4-2-17)26(30,27(31,32)33)28(34,35)36)13-14-37(16-25)21(38)23-9-11-24(15-23,12-10-23)22(39)40/h1-8H,9-16H2,(H,39,40)/t23?,24?,25-/m0/s1 XHTMLUDJBICVHB-STEQJIOHSA-N 253437 US9458171, 397 Nuclear receptor ROR-gamma [262-507] 1344 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253437 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253437&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118207907 346547802 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440939 OC(=O)C12C3C4C1C1C2C3C41C(=O)N1CC[C@](C1)(c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C29H21F8NO5S/c30-14-5-7-15(8-6-14)44(42,43)24(12-1-3-13(4-2-12)27(31,28(32,33)34)29(35,36)37)9-10-38(11-24)22(39)25-16-19-17(25)21-18(25)20(16)26(19,21)23(40)41/h1-8,16-21H,9-11H2,(H,40,41)/t16?,17?,18?,19?,20?,21?,24-,25?,26?/m0/s1 GAANOEMTZKTQKG-WTJSYROLSA-N 253438 US9458171, 398 Nuclear receptor ROR-gamma [262-507] 106 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253438 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253438&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217864 346547803 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440940 OC(=O)[C@@H]1[C@H]2C[C@@H](C[C@@H]12)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C27H23F8NO5S/c28-17-5-7-18(8-6-17)42(40,41)24(15-1-3-16(4-2-15)25(29,26(30,31)32)27(33,34)35)9-10-36(13-24)22(37)14-11-19-20(12-14)21(19)23(38)39/h1-8,14,19-21H,9-13H2,(H,38,39)/t14-,19-,20+,21+,24-/m0/s1 HNOZQRKROBDUDI-LPSQLEIASA-N 253439 US9458171, 399 Nuclear receptor ROR-gamma [262-507] 82 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253439 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253439&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217865 346547804 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440941 OC(=O)[C@H]1C[C@H]2[C@@H](C1)[C@@H]2C(=O)N1CC[C@](C1)(c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C27H23F8NO5S/c28-17-5-7-18(8-6-17)42(40,41)24(15-1-3-16(4-2-15)25(29,26(30,31)32)27(33,34)35)9-10-36(13-24)22(37)21-19-11-14(23(38)39)12-20(19)21/h1-8,14,19-21H,9-13H2,(H,38,39)/t14-,19-,20+,21+,24-/m0/s1 MVMNXAJUCHJIFB-LPSQLEIASA-N 253440 US9458171, 400 Nuclear receptor ROR-gamma [262-507] 159 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253440 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253440&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217866 346547805 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440942 Fc1ccc(cc1)S(=O)(=O)[C@]1(CCN(C1)C(=O)[C@H]1CC[C@@H](CC1)c1nnn[nH]1)c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F 253441 US9458171, 401 Nuclear receptor ROR-gamma [262-507] 109 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253441 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253441&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217867 346547806 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440943 OC(=O)C12CCC(CC1)(OC2)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H25F8NO6S/c29-19-5-7-20(8-6-19)44(41,42)25(17-1-3-18(4-2-17)26(30,27(31,32)33)28(34,35)36)13-14-37(15-25)21(38)24-11-9-23(10-12-24,16-43-24)22(39)40/h1-8H,9-16H2,(H,39,40)/t23?,24?,25-/m0/s1 BVABKVKAEGWJRT-STEQJIOHSA-N 253442 US9458171, 402 Nuclear receptor ROR-gamma [262-507] 51 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253442 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253442&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217868 346547807 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440944 OC(=O)C12CCC(CC1)(CO2)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H25F8NO6S/c29-19-5-7-20(8-6-19)44(41,42)25(17-1-3-18(4-2-17)26(30,27(31,32)33)28(34,35)36)13-14-37(15-25)21(38)23-9-11-24(12-10-23,22(39)40)43-16-23/h1-8H,9-16H2,(H,39,40)/t23?,24?,25-/m0/s1 XFTCOOLWDUDCCF-STEQJIOHSA-N 253443 US9458171, 403 Nuclear receptor ROR-gamma [262-507] 40 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253443 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253443&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217869 346547808 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440945 OC(=O)[C@H]1[C@H]2C[C@@H](C[C@@H]12)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C27H23F8NO5S/c28-17-5-7-18(8-6-17)42(40,41)24(15-1-3-16(4-2-15)25(29,26(30,31)32)27(33,34)35)9-10-36(13-24)22(37)14-11-19-20(12-14)21(19)23(38)39/h1-8,14,19-21H,9-13H2,(H,38,39)/t14-,19-,20+,21-,24-/m0/s1 HNOZQRKROBDUDI-VYNBFOJNSA-N 253444 US9458171, 404 Nuclear receptor ROR-gamma [262-507] 1283 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253444 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253444&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217865 346547809 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440946 Fc1ccc(cc1)S(=O)(=O)[C@]1(CCN(C1)C(=O)C1CCC2(CC1)NC(=O)NC2=O)c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F InChI=1S/C28H25F8N3O5S/c29-19-5-7-20(8-6-19)45(43,44)25(17-1-3-18(4-2-17)26(30,27(31,32)33)28(34,35)36)13-14-39(15-25)21(40)16-9-11-24(12-10-16)22(41)37-23(42)38-24/h1-8,16H,9-15H2,(H2,37,38,41,42)/t16?,24?,25-/m0/s1 QJZRZLRWRGWGLC-ITNSIVGMSA-N 253445 US9458171, 405::US9458171, 406 Nuclear receptor ROR-gamma [262-507] 1265 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253445 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253445&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217870 346547810 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440947 Fc1ccc(cc1)S(=O)(=O)[C@]1(CCN(C1)C(=O)C1CCC2(CC1)NC(=O)NC2=O)c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F InChI=1S/C28H25F8N3O5S/c29-19-5-7-20(8-6-19)45(43,44)25(17-1-3-18(4-2-17)26(30,27(31,32)33)28(34,35)36)13-14-39(15-25)21(40)16-9-11-24(12-10-16)22(41)37-23(42)38-24/h1-8,16H,9-15H2,(H2,37,38,41,42)/t16?,24?,25-/m0/s1 QJZRZLRWRGWGLC-ITNSIVGMSA-N 253445 US9458171, 405::US9458171, 406 Nuclear receptor ROR-gamma [262-507] 259 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253445 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253445&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217870 346547810 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440948 COCC1(CCC(CC1)C(O)=O)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C29H29F8NO6S/c1-44-17-25(12-10-18(11-13-25)23(39)40)24(41)38-15-14-26(16-38,45(42,43)22-8-6-21(30)7-9-22)19-2-4-20(5-3-19)27(31,28(32,33)34)29(35,36)37/h2-9,18H,10-17H2,1H3,(H,39,40)/t18?,25?,26-/m0/s1 VTXAHBUSZIDRJU-JXURVNHXSA-N 253447 US9458171, 407 Nuclear receptor ROR-gamma [262-507] 66 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253447 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253447&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217871 346547811 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440949 OC(=O)C1CCC(CF)(CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H26F9NO5S/c29-15-24(11-9-17(10-12-24)22(39)40)23(41)38-14-13-25(16-38,44(42,43)21-7-5-20(30)6-8-21)18-1-3-19(4-2-18)26(31,27(32,33)34)28(35,36)37/h1-8,17H,9-16H2,(H,39,40)/t17?,24?,25-/m0/s1 BAVCAZGYDLKIJN-RIIRKCAYSA-N 253448 US9458171, 408 Nuclear receptor ROR-gamma [262-507] 955 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253448 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253448&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217872 346547812 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440950 OC(=O)C1CCC(CF)(CC1)C(=O)N1CC[C@@](C1)(c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H26F9NO5S/c29-15-24(11-9-17(10-12-24)22(39)40)23(41)38-14-13-25(16-38,44(42,43)21-7-5-20(30)6-8-21)18-1-3-19(4-2-18)26(31,27(32,33)34)28(35,36)37/h1-8,17H,9-16H2,(H,39,40)/t17?,24?,25-/m1/s1 BAVCAZGYDLKIJN-XPBUXGOKSA-N 253449 US9458171, 409 Nuclear receptor ROR-gamma [262-507] 80 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253449 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253449&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 131636476 346547813 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440951 Fc1ccc(cc1)S(=O)(=O)[C@]1(CCN(C1)C(=O)C1CCC(=O)CC1)c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F InChI=1S/C26H23F8NO4S/c27-19-7-11-21(12-8-19)40(38,39)23(13-14-35(15-23)22(37)16-1-9-20(36)10-2-16)17-3-5-18(6-4-17)24(28,25(29,30)31)26(32,33)34/h3-8,11-12,16H,1-2,9-10,13-15H2/t23-/m0/s1 KMFPBRFAIUMNQB-QHCPKHFHSA-N 253450 US9458171, 410 Nuclear receptor ROR-gamma [262-507] 89 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253450 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253450&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217873 346547814 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440952 COC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H27F8NO5S/c1-42-24(39)18-4-2-17(3-5-18)23(38)37-15-14-25(16-37,43(40,41)22-12-10-21(29)11-13-22)19-6-8-20(9-7-19)26(30,27(31,32)33)28(34,35)36/h6-13,17-18H,2-5,14-16H2,1H3/t17-,18-,25-/m0/s1 FXDAKWRVQKBLSG-RPPIVITFSA-N 253451 US9458171, 411 Nuclear receptor ROR-gamma [262-507] 1186 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253451 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253451&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217874 346547815 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440953 CC(=O)C12CCC(CC1)(C2)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C29H27F8NO4S/c1-18(39)24-10-12-25(16-24,13-11-24)23(40)38-15-14-26(17-38,43(41,42)22-8-6-21(30)7-9-22)19-2-4-20(5-3-19)27(31,28(32,33)34)29(35,36)37/h2-9H,10-17H2,1H3/t24?,25?,26-/m0/s1 VMHLJKDCZAQASI-WNMGUVTHSA-N 253452 US9458171, 412 Nuclear receptor ROR-gamma [262-507] 266 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253452 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253452&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118208111 346547816 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440954 CC(C)(O)C12CCC(CC1)(C2)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C30H31F8NO4S/c1-24(2,41)26-13-11-25(17-26,12-14-26)23(40)39-16-15-27(18-39,44(42,43)22-9-7-21(31)8-10-22)19-3-5-20(6-4-19)28(32,29(33,34)35)30(36,37)38/h3-10,41H,11-18H2,1-2H3/t25?,26?,27-/m0/s1 HRXQYJNSWKJWMI-RCSZBHJWSA-N 253453 US9458171, 413 Nuclear receptor ROR-gamma [262-507] 320 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253453 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253453&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118207906 346547817 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440955 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(cc1)N=[N+]=[N-] InChI=1S/C27H25F7N4O5S/c28-25(26(29,30)31,27(32,33)34)19-7-5-18(6-8-19)24(44(42,43)21-11-9-20(10-12-21)36-37-35)13-14-38(15-24)22(39)16-1-3-17(4-2-16)23(40)41/h5-12,16-17H,1-4,13-15H2,(H,40,41)/t16-,17-,24-/m0/s1 BYBCVZWHHIRAPG-UAVUOLJFSA-N 253454 US9458171, 414 Nuclear receptor ROR-gamma [262-507] 62 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253454 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253454&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118207964 346547818 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440956 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(Cl)cc1 InChI=1S/C27H25ClF7NO5S/c28-20-9-11-21(12-10-20)42(40,41)24(13-14-36(15-24)22(37)16-1-3-17(4-2-16)23(38)39)18-5-7-19(8-6-18)25(29,26(30,31)32)27(33,34)35/h5-12,16-17H,1-4,13-15H2,(H,38,39)/t16-,17-,24-/m0/s1 OWEBVLUQSSGDRX-UAVUOLJFSA-N 253455 US9458171, 415 Nuclear receptor ROR-gamma [262-507] 92 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253455 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253455&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118208026 346547819 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440957 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(Br)cc1 InChI=1S/C27H25BrF7NO5S/c28-20-9-11-21(12-10-20)42(40,41)24(13-14-36(15-24)22(37)16-1-3-17(4-2-16)23(38)39)18-5-7-19(8-6-18)25(29,26(30,31)32)27(33,34)35/h5-12,16-17H,1-4,13-15H2,(H,38,39)/t16-,17-,24-/m0/s1 YKFWLWUMLCBSFF-UAVUOLJFSA-N 253456 US9458171, 416 Nuclear receptor ROR-gamma [262-507] 79 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253456 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253456&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118208140 346547820 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440958 Cc1ccc(cc1)S(=O)(=O)[C@]1(CCN(C1)C(=O)[C@H]1CC[C@@H](CC1)C(O)=O)c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F InChI=1S/C28H28F7NO5S/c1-17-2-12-22(13-3-17)42(40,41)25(14-15-36(16-25)23(37)18-4-6-19(7-5-18)24(38)39)20-8-10-21(11-9-20)26(29,27(30,31)32)28(33,34)35/h2-3,8-13,18-19H,4-7,14-16H2,1H3,(H,38,39)/t18-,19-,25-/m0/s1 PSNZDXCQJULFRM-MHPIHPPYSA-N 253457 US9458171, 417 Nuclear receptor ROR-gamma [262-507] 121 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253457 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253457&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118208086 346547821 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440959 Cc1ccc(cc1C)S(=O)(=O)[C@]1(CCN(C1)C(=O)[C@H]1CC[C@@H](CC1)C(O)=O)c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F InChI=1S/C29H30F7NO5S/c1-17-3-12-23(15-18(17)2)43(41,42)26(13-14-37(16-26)24(38)19-4-6-20(7-5-19)25(39)40)21-8-10-22(11-9-21)27(30,28(31,32)33)29(34,35)36/h3,8-12,15,19-20H,4-7,13-14,16H2,1-2H3,(H,39,40)/t19-,20-,26-/m0/s1 VANBWFYZOYNUCY-DYLHXGEVSA-N 253458 US9458171, 418 Nuclear receptor ROR-gamma [262-507] 74 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253458 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253458&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118207894 346547822 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440960 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(C=C)cc1 InChI=1S/C29H28F7NO5S/c1-2-18-3-13-23(14-4-18)43(41,42)26(15-16-37(17-26)24(38)19-5-7-20(8-6-19)25(39)40)21-9-11-22(12-10-21)27(30,28(31,32)33)29(34,35)36/h2-4,9-14,19-20H,1,5-8,15-17H2,(H,39,40)/t19-,20-,26-/m0/s1 TZDOIPQOSHYJOM-DYLHXGEVSA-N 253459 US9458171, 419 Nuclear receptor ROR-gamma [262-507] 55 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253459 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253459&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118208149 346547823 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440961 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(cc1)-c1ccccc1 InChI=1S/C33H30F7NO5S/c34-31(32(35,36)37,33(38,39)40)26-14-12-25(13-15-26)30(18-19-41(20-30)28(42)23-6-8-24(9-7-23)29(43)44)47(45,46)27-16-10-22(11-17-27)21-4-2-1-3-5-21/h1-5,10-17,23-24H,6-9,18-20H2,(H,43,44)/t23-,24-,30-/m0/s1 NDFHVLDJJGLJQH-JYUFKMNQSA-N 253460 US9458171, 420 Nuclear receptor ROR-gamma [262-507] 4621 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253460 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253460&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118208118 346547824 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440962 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(cc1)C1CC1 InChI=1S/C30H30F7NO5S/c31-28(29(32,33)34,30(35,36)37)23-11-9-22(10-12-23)27(44(42,43)24-13-7-19(8-14-24)18-1-2-18)15-16-38(17-27)25(39)20-3-5-21(6-4-20)26(40)41/h7-14,18,20-21H,1-6,15-17H2,(H,40,41)/t20-,21-,27-/m0/s1 GHGHIBNLISRAEE-IZVMNLJQSA-N 253461 US9458171, 421 Nuclear receptor ROR-gamma [262-507] 166 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253461 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253461&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118208158 346547825 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440963 CCc1ccc(cc1)S(=O)(=O)[C@]1(CCN(C1)C(=O)[C@H]1CC[C@@H](CC1)C(O)=O)c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F InChI=1S/C29H30F7NO5S/c1-2-18-3-13-23(14-4-18)43(41,42)26(15-16-37(17-26)24(38)19-5-7-20(8-6-19)25(39)40)21-9-11-22(12-10-21)27(30,28(31,32)33)29(34,35)36/h3-4,9-14,19-20H,2,5-8,15-17H2,1H3,(H,39,40)/t19-,20-,26-/m0/s1 LABVKPUHHCCTTJ-DYLHXGEVSA-N 253462 US9458171, 422 Nuclear receptor ROR-gamma [262-507] 110 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253462 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253462&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217875 346547826 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440964 COC1(CCC(CO)CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H29F8NO5S/c1-42-24(12-10-18(16-38)11-13-24)23(39)37-15-14-25(17-37,43(40,41)22-8-6-21(29)7-9-22)19-2-4-20(5-3-19)26(30,27(31,32)33)28(34,35)36/h2-9,18,38H,10-17H2,1H3/t18?,24?,25-/m0/s1 WMSJWTLTWASIPH-VHNLKAGOSA-N 253463 US9458171, 423 Nuclear receptor ROR-gamma [262-507] 426 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253463 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253463&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118208156 346547827 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440965 COC1(CCC(CO)CC1)C(=O)N1CC[C@@](C1)(c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H29F8NO5S/c1-42-24(12-10-18(16-38)11-13-24)23(39)37-15-14-25(17-37,43(40,41)22-8-6-21(29)7-9-22)19-2-4-20(5-3-19)26(30,27(31,32)33)28(34,35)36/h2-9,18,38H,10-17H2,1H3/t18?,24?,25-/m1/s1 WMSJWTLTWASIPH-QJDQLVHXSA-N 253464 US9458171, 424 Nuclear receptor ROR-gamma [262-507] 140 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253464 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253464&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 131636477 346547828 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440966 COC1(CCC(CC1)C(O)=O)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H27F8NO6S/c1-43-24(12-10-17(11-13-24)22(38)39)23(40)37-15-14-25(16-37,44(41,42)21-8-6-20(29)7-9-21)18-2-4-19(5-3-18)26(30,27(31,32)33)28(34,35)36/h2-9,17H,10-16H2,1H3,(H,38,39)/t17?,24?,25-/m0/s1 VOICMNBKPATLIE-RIIRKCAYSA-N 253465 US9458171, 425 Nuclear receptor ROR-gamma [262-507] 53 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253465 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253465&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118208048 346547829 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440967 COC1(CCC(CC1)C(O)=O)C(=O)N1CC[C@@](C1)(c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H27F8NO6S/c1-43-24(12-10-17(11-13-24)22(38)39)23(40)37-15-14-25(16-37,44(41,42)21-8-6-20(29)7-9-21)18-2-4-19(5-3-18)26(30,27(31,32)33)28(34,35)36/h2-9,17H,10-16H2,1H3,(H,38,39)/t17?,24?,25-/m1/s1 VOICMNBKPATLIE-XPBUXGOKSA-N 253466 US9458171, 426 Nuclear receptor ROR-gamma [262-507] 514 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253466 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253466&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 131636478 346547830 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440968 COC1(CCC(CC1)C(O)=O)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)c(C)c1 InChI=1S/C29H29F8NO6S/c1-17-15-21(7-8-22(17)30)45(42,43)26(19-3-5-20(6-4-19)27(31,28(32,33)34)29(35,36)37)13-14-38(16-26)24(41)25(44-2)11-9-18(10-12-25)23(39)40/h3-8,15,18H,9-14,16H2,1-2H3,(H,39,40)/t18?,25?,26-/m0/s1 YWVBBDISRGXAJT-JXURVNHXSA-N 253467 US9458171, 427 Nuclear receptor ROR-gamma [262-507] 66 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253467 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253467&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118207864 346547831 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440969 COC1(CCC(CC1)C(O)=O)C(=O)N1CC[C@@](C1)(c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)c(C)c1 InChI=1S/C29H29F8NO6S/c1-17-15-21(7-8-22(17)30)45(42,43)26(19-3-5-20(6-4-19)27(31,28(32,33)34)29(35,36)37)13-14-38(16-26)24(41)25(44-2)11-9-18(10-12-25)23(39)40/h3-8,15,18H,9-14,16H2,1-2H3,(H,39,40)/t18?,25?,26-/m1/s1 YWVBBDISRGXAJT-UQDURWBFSA-N 253468 US9458171, 428 Nuclear receptor ROR-gamma [262-507] 292 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253468 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253468&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 131636479 346547832 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440970 OC(=O)C1CCC(=CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C27H23F8NO5S/c28-20-9-11-21(12-10-20)42(40,41)24(13-14-36(15-24)22(37)16-1-3-17(4-2-16)23(38)39)18-5-7-19(8-6-18)25(29,26(30,31)32)27(33,34)35/h1,5-12,17H,2-4,13-15H2,(H,38,39)/t17?,24-/m0/s1 SPVFTPWNFKBQRE-UCSBTNPJSA-N 253469 US9458171, 429 Nuclear receptor ROR-gamma [262-507] 338 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253469 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253469&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118208076 346547833 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440971 Cc1ccc(cc1F)S(=O)(=O)[C@]1(CCN(Cc2ccccc2)C1)c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F InChI=1S/C27H23F8NO2S/c1-18-7-12-22(15-23(18)28)39(37,38)24(13-14-36(17-24)16-19-5-3-2-4-6-19)20-8-10-21(11-9-20)25(29,26(30,31)32)27(33,34)35/h2-12,15H,13-14,16-17H2,1H3/t24-/m0/s1 ILLRVKROEYFTAD-DEOSSOPVSA-N 253470 US9458171, 430 Nuclear receptor ROR-gamma [262-507] 3771 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253470 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253470&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118208171 346547834 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440972 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(O)cc1 InChI=1S/C27H26F7NO6S/c28-25(26(29,30)31,27(32,33)34)19-7-5-18(6-8-19)24(42(40,41)21-11-9-20(36)10-12-21)13-14-35(15-24)22(37)16-1-3-17(4-2-16)23(38)39/h5-12,16-17,36H,1-4,13-15H2,(H,38,39)/t16-,17-,24-/m0/s1 LOXXUYWPRHTOTL-UAVUOLJFSA-N 253471 US9458171, 431 Nuclear receptor ROR-gamma [262-507] 4222 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253471 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253471&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118208105 346547835 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440973 Cc1ccc(cc1F)S(=O)(=O)[C@@]1(CCN(C1)C(=O)[C@H]1CC[C@@H](CC1)C(O)=O)c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F InChI=1S/C28H27F8NO5S/c1-16-2-11-21(14-22(16)29)43(41,42)25(12-13-37(15-25)23(38)17-3-5-18(6-4-17)24(39)40)19-7-9-20(10-8-19)26(30,27(31,32)33)28(34,35)36/h2,7-11,14,17-18H,3-6,12-13,15H2,1H3,(H,39,40)/t17-,18-,25-/m1/s1 BLNUOGVXFZHOPR-QJMRKGMQSA-N 253472 US9458171, 432 Nuclear receptor ROR-gamma [262-507] 1860 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253472 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253472&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217877 346547836 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440974 Cc1ccc(cc1F)S(=O)(=O)[C@]1(CCN(C1)C(=O)[C@H]1CC[C@@H](CC1)C(O)=O)c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F InChI=1S/C28H27F8NO5S/c1-16-2-11-21(14-22(16)29)43(41,42)25(12-13-37(15-25)23(38)17-3-5-18(6-4-17)24(39)40)19-7-9-20(10-8-19)26(30,27(31,32)33)28(34,35)36/h2,7-11,14,17-18H,3-6,12-13,15H2,1H3,(H,39,40)/t17-,18-,25-/m0/s1 BLNUOGVXFZHOPR-RPPIVITFSA-N 253473 US9458171, 433 Nuclear receptor ROR-gamma [262-507] 310 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253473 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253473&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217878 346547837 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440975 CC[C@@]1(CC[C@@H](CC1)C(O)=O)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(C)c(F)c1 InChI=1S/C30H31F8NO5S/c1-3-26(12-10-19(11-13-26)24(40)41)25(42)39-15-14-27(17-39,45(43,44)22-9-4-18(2)23(31)16-22)20-5-7-21(8-6-20)28(32,29(33,34)35)30(36,37)38/h4-9,16,19H,3,10-15,17H2,1-2H3,(H,40,41)/t19-,26-,27-/m0/s1 BYIRJPRGMMSZSA-DOYMOWJKSA-N 253474 US9458171, 434 Nuclear receptor ROR-gamma [262-507] 670 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253474 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253474&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217880 346547838 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440976 Cc1ccc(cc1F)S(=O)(=O)[C@]1(CCN(C1)C(=O)C12CCC(CC1)(CC2)C(O)=O)c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F InChI=1S/C30H29F8NO5S/c1-18-2-7-21(16-22(18)31)45(43,44)27(19-3-5-20(6-4-19)28(32,29(33,34)35)30(36,37)38)14-15-39(17-27)23(40)25-8-11-26(12-9-25,13-10-25)24(41)42/h2-7,16H,8-15,17H2,1H3,(H,41,42)/t25?,26?,27-/m0/s1 VJFVTOOHMDOIJG-RCSZBHJWSA-N 253475 US9458171, 435 Nuclear receptor ROR-gamma [262-507] 107 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253475 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253475&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217879 346547839 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440977 Cc1ccc(cc1F)S(=O)(=O)[C@]1(CCN(C1)C(=O)[C@@]1(F)CC[C@@H](CC1)C(O)=O)c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F InChI=1S/C28H26F9NO5S/c1-16-2-7-20(14-21(16)29)44(42,43)25(18-3-5-19(6-4-18)26(31,27(32,33)34)28(35,36)37)12-13-38(15-25)23(41)24(30)10-8-17(9-11-24)22(39)40/h2-7,14,17H,8-13,15H2,1H3,(H,39,40)/t17-,24+,25-/m0/s1 CDQIUTLETSHCLA-AJHZIAPWSA-N 253476 US9458171, 436 Nuclear receptor ROR-gamma [262-507] 254 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253476 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253476&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217881 346547840 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440978 Cc1ccc(cc1F)S(=O)(=O)[C@]1(CCN(C1)C(=O)[C@H]1CC[C@@](C)(CC1)C(O)=O)c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F InChI=1S/C29H29F8NO5S/c1-17-3-8-21(15-22(17)30)44(42,43)26(19-4-6-20(7-5-19)27(31,28(32,33)34)29(35,36)37)13-14-38(16-26)23(39)18-9-11-25(2,12-10-18)24(40)41/h3-8,15,18H,9-14,16H2,1-2H3,(H,40,41)/t18-,25-,26-/m0/s1 PSTDIRZJJLTRID-ATANMQQVSA-N 253477 US9458171, 437 Nuclear receptor ROR-gamma [262-507] 72 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253477 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253477&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217883 346547841 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440979 CC(C)(C)OC(=O)N1CC[C@](C1)(c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(Br)cc1 InChI=1S/C24H23BrF7NO4S/c1-20(2,3)37-19(34)33-13-12-21(14-33,38(35,36)18-10-8-17(25)9-11-18)15-4-6-16(7-5-15)22(26,23(27,28)29)24(30,31)32/h4-11H,12-14H2,1-3H3/t21-/m0/s1 GDMDCYPWJBKXFH-NRFANRHFSA-N 253478 US9458171, 438 Nuclear receptor ROR-gamma [262-507] 609 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253478 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253478&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217882 346547842 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440980 CC(F)(c1ccc(cc1)[C@@]1(CCN(C1)C(=O)[C@H]1CC[C@@H](CC1)C(O)=O)S(=O)(=O)c1ccc(F)cc1)C(F)(F)F InChI=1S/C27H28F5NO5S/c1-25(29,27(30,31)32)19-6-8-20(9-7-19)26(39(37,38)22-12-10-21(28)11-13-22)14-15-33(16-26)23(34)17-2-4-18(5-3-17)24(35)36/h6-13,17-18H,2-5,14-16H2,1H3,(H,35,36)/t17-,18-,25?,26-/m0/s1 LGQOXMLFBZDWKB-FTZVLGSBSA-N 253479 US9458171, 439 Nuclear receptor ROR-gamma [262-507] 174 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253479 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253479&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118207860 346547843 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440981 CC(O)(c1ccc(cc1)[C@@]1(CCN(C1)C(=O)[C@H]1CC[C@@H](CC1)C(O)=O)S(=O)(=O)c1ccc(F)cc1)C(F)(F)F InChI=1S/C27H29F4NO6S/c1-25(36,27(29,30)31)19-6-8-20(9-7-19)26(39(37,38)22-12-10-21(28)11-13-22)14-15-32(16-26)23(33)17-2-4-18(5-3-17)24(34)35/h6-13,17-18,36H,2-5,14-16H2,1H3,(H,34,35)/t17-,18-,25?,26-/m0/s1 DPEWSBOYUOMMPB-FTZVLGSBSA-N 253480 US9458171, 440 Nuclear receptor ROR-gamma [262-507] 583 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253480 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253480&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118207917 346547844 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440982 FC(F)(F)C(F)(c1ccc(cc1)[C@]1(CCN(C1)C(=O)Cc1ccncc1)S(=O)(=O)c1cccc(Br)c1)C(F)(F)F InChI=1S/C26H20BrF7N2O3S/c27-20-2-1-3-21(15-20)40(38,39)23(10-13-36(16-23)22(37)14-17-8-11-35-12-9-17)18-4-6-19(7-5-18)24(28,25(29,30)31)26(32,33)34/h1-9,11-12,15H,10,13-14,16H2/t23-/m1/s1 DDVCFNVIIKKEKI-HSZRJFAPSA-N 253481 US9458171, 441 Nuclear receptor ROR-gamma [262-507] 2356 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253481 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253481&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 131636480 346547845 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440983 FC(F)(F)C(F)(c1ccc(cc1)[C@@]1(CCN(C1)C(=O)Cc1ccncc1)S(=O)(=O)c1cccc(Br)c1)C(F)(F)F InChI=1S/C26H20BrF7N2O3S/c27-20-2-1-3-21(15-20)40(38,39)23(10-13-36(16-23)22(37)14-17-8-11-35-12-9-17)18-4-6-19(7-5-18)24(28,25(29,30)31)26(32,33)34/h1-9,11-12,15H,10,13-14,16H2/t23-/m0/s1 DDVCFNVIIKKEKI-QHCPKHFHSA-N 253482 US9458171, 442 Nuclear receptor ROR-gamma [262-507] 225 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253482 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253482&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 131636481 346547846 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440984 Cc1cccc(c1)S(=O)(=O)C1(CCN(C1)C(=O)[C@H]1CC[C@@H](CC1)C(O)=O)c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F InChI=1S/C28H28F7NO5S/c1-17-3-2-4-22(15-17)42(40,41)25(13-14-36(16-25)23(37)18-5-7-19(8-6-18)24(38)39)20-9-11-21(12-10-20)26(29,27(30,31)32)28(33,34)35/h2-4,9-12,15,18-19H,5-8,13-14,16H2,1H3,(H,38,39)/t18-,19-,25? XAEMLXHWAAXRLV-DFPMAXHOSA-N 253483 US9458171, 443 Nuclear receptor ROR-gamma [262-507] 88 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253483 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253483&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118208078 346547847 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440985 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CCC(C1)(c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1cccc(C=C)c1 InChI=1S/C29H28F7NO5S/c1-2-18-4-3-5-23(16-18)43(41,42)26(14-15-37(17-26)24(38)19-6-8-20(9-7-19)25(39)40)21-10-12-22(13-11-21)27(30,28(31,32)33)29(34,35)36/h2-5,10-13,16,19-20H,1,6-9,14-15,17H2,(H,39,40)/t19-,20-,26? QBOPOTMHSKVTPM-NMUBWLRRSA-N 253484 US9458171, 444 Nuclear receptor ROR-gamma [262-507] 220 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253484 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253484&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217884 346547848 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440986 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CCC(C1)(c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1cccc(c1)C1CC1 InChI=1S/C30H30F7NO5S/c31-28(29(32,33)34,30(35,36)37)23-12-10-22(11-13-23)27(44(42,43)24-3-1-2-21(16-24)18-4-5-18)14-15-38(17-27)25(39)19-6-8-20(9-7-19)26(40)41/h1-3,10-13,16,18-20H,4-9,14-15,17H2,(H,40,41)/t19-,20-,27? LBVADVRQTJCTJH-DKFXBIDSSA-N 253485 US9458171, 445 Nuclear receptor ROR-gamma [262-507] 47 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253485 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253485&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217885 346547849 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440987 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CCC(C1)(c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1cccc(c1)-c1ccccc1 InChI=1S/C33H30F7NO5S/c34-31(32(35,36)37,33(38,39)40)26-15-13-25(14-16-26)30(17-18-41(20-30)28(42)22-9-11-23(12-10-22)29(43)44)47(45,46)27-8-4-7-24(19-27)21-5-2-1-3-6-21/h1-8,13-16,19,22-23H,9-12,17-18,20H2,(H,43,44)/t22-,23-,30? IWDPHZWDYDKFEP-BTWCTINZSA-N 253486 US9458171, 446 Nuclear receptor ROR-gamma [262-507] 51 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253486 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253486&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217888 346547850 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440988 Cn1cc(cn1)-c1cccc(c1)S(=O)(=O)C1(CCN(C1)C(=O)[C@H]1CC[C@@H](CC1)C(O)=O)c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F InChI=1S/C31H30F7N3O5S/c1-40-17-22(16-39-40)21-3-2-4-25(15-21)47(45,46)28(13-14-41(18-28)26(42)19-5-7-20(8-6-19)27(43)44)23-9-11-24(12-10-23)29(32,30(33,34)35)31(36,37)38/h2-4,9-12,15-17,19-20H,5-8,13-14,18H2,1H3,(H,43,44)/t19-,20-,28? MBXJZOWDOORUFL-KLBFEONNSA-N 253487 US9458171, 447 Nuclear receptor ROR-gamma [262-507] 606 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253487 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253487&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217886 346547851 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440989 Cc1ccccc1-c1cccc(c1)S(=O)(=O)C1(CCN(C1)C(=O)[C@H]1CC[C@@H](CC1)C(O)=O)c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F InChI=1S/C34H32F7NO5S/c1-21-5-2-3-8-28(21)24-6-4-7-27(19-24)48(46,47)31(17-18-42(20-31)29(43)22-9-11-23(12-10-22)30(44)45)25-13-15-26(16-14-25)32(35,33(36,37)38)34(39,40)41/h2-8,13-16,19,22-23H,9-12,17-18,20H2,1H3,(H,44,45)/t22-,23-,31? QOXUITWBGMLWCO-LCOQZQPXSA-N 253488 US9458171, 448 Nuclear receptor ROR-gamma [262-507] 1288 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253488 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253488&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217887 346547852 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440990 Cc1cccc(c1)-c1cccc(c1)S(=O)(=O)C1(CCN(C1)C(=O)[C@H]1CC[C@@H](CC1)C(O)=O)c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F InChI=1S/C34H32F7NO5S/c1-21-4-2-5-24(18-21)25-6-3-7-28(19-25)48(46,47)31(16-17-42(20-31)29(43)22-8-10-23(11-9-22)30(44)45)26-12-14-27(15-13-26)32(35,33(36,37)38)34(39,40)41/h2-7,12-15,18-19,22-23H,8-11,16-17,20H2,1H3,(H,44,45)/t22-,23-,31? QQEDUJFXJVEPKQ-LCOQZQPXSA-N 253489 US9458171, 449 Nuclear receptor ROR-gamma [262-507] 1526 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253489 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253489&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217889 346547853 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440991 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CCC(C1)(c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1cccc(c1)-c1cccc(c1)C#N InChI=1S/C34H29F7N2O5S/c35-32(33(36,37)38,34(39,40)41)27-13-11-26(12-14-27)31(15-16-43(20-31)29(44)22-7-9-23(10-8-22)30(45)46)49(47,48)28-6-2-5-25(18-28)24-4-1-3-21(17-24)19-42/h1-6,11-14,17-18,22-23H,7-10,15-16,20H2,(H,45,46)/t22-,23-,31? XEFURQLMAOKIDI-LCOQZQPXSA-N 253490 US9458171, 450 Nuclear receptor ROR-gamma [262-507] 2390 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253490 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253490&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217890 346547854 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440992 Cc1ccc(cc1)-c1cccc(c1)S(=O)(=O)C1(CCN(C1)C(=O)[C@H]1CC[C@@H](CC1)C(O)=O)c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F InChI=1S/C34H32F7NO5S/c1-21-5-7-22(8-6-21)25-3-2-4-28(19-25)48(46,47)31(17-18-42(20-31)29(43)23-9-11-24(12-10-23)30(44)45)26-13-15-27(16-14-26)32(35,33(36,37)38)34(39,40)41/h2-8,13-16,19,23-24H,9-12,17-18,20H2,1H3,(H,44,45)/t23-,24-,31? CQAMOIOSEJHOFT-SWZCCTPQSA-N 253491 US9458171, 451 Nuclear receptor ROR-gamma [262-507] 825 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253491 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253491&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217891 346547855 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440993 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CCC(C1)(c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1cccc(c1)-c1ccsc1 InChI=1S/C31H28F7NO5S2/c32-29(30(33,34)35,31(36,37)38)24-10-8-23(9-11-24)28(46(43,44)25-3-1-2-21(16-25)22-12-15-45-17-22)13-14-39(18-28)26(40)19-4-6-20(7-5-19)27(41)42/h1-3,8-12,15-17,19-20H,4-7,13-14,18H2,(H,41,42)/t19-,20-,28? HPVRQFMBHHVKOJ-KLBFEONNSA-N 253492 US9458171, 452 Nuclear receptor ROR-gamma [262-507] 86 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253492 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253492&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217892 346547856 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440994 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CCC(C1)(c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1cccc(c1)-c1ccncc1 InChI=1S/C32H29F7N2O5S/c33-30(31(34,35)36,32(37,38)39)25-10-8-24(9-11-25)29(14-17-41(19-29)27(42)21-4-6-22(7-5-21)28(43)44)47(45,46)26-3-1-2-23(18-26)20-12-15-40-16-13-20/h1-3,8-13,15-16,18,21-22H,4-7,14,17,19H2,(H,43,44)/t21-,22-,29? HCBSWRMOYTYSKA-FKCXMHPPSA-N 253493 US9458171, 453 Nuclear receptor ROR-gamma [262-507] 152 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253493 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253493&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217893 346547857 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440995 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CCC(C1)(c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1cccc(c1)-c1ccccn1 InChI=1S/C32H29F7N2O5S/c33-30(31(34,35)36,32(37,38)39)24-13-11-23(12-14-24)29(15-17-41(19-29)27(42)20-7-9-21(10-8-20)28(43)44)47(45,46)25-5-3-4-22(18-25)26-6-1-2-16-40-26/h1-6,11-14,16,18,20-21H,7-10,15,17,19H2,(H,43,44)/t20-,21-,29? RLGWOSFMZXKRJB-XSUAGSRNSA-N 253494 US9458171, 454 Nuclear receptor ROR-gamma [262-507] 405 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253494 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253494&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118208152 346547858 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440996 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CCC(C1)(c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccccc1 InChI=1S/C27H26F7NO5S/c28-25(26(29,30)31,27(32,33)34)20-12-10-19(11-13-20)24(41(39,40)21-4-2-1-3-5-21)14-15-35(16-24)22(36)17-6-8-18(9-7-17)23(37)38/h1-5,10-13,17-18H,6-9,14-16H2,(H,37,38)/t17-,18-,24? YFUAPIFVWFDXKT-NUJJYFHVSA-N 253495 US9458171, 455 Nuclear receptor ROR-gamma [262-507] 103 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253495 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253495&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118207833 346547859 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440997 CCc1cccc(c1)S(=O)(=O)C1(CCN(C1)C(=O)[C@H]1CC[C@@H](CC1)C(O)=O)c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F InChI=1S/C29H30F7NO5S/c1-2-18-4-3-5-23(16-18)43(41,42)26(14-15-37(17-26)24(38)19-6-8-20(9-7-19)25(39)40)21-10-12-22(13-11-21)27(30,28(31,32)33)29(34,35)36/h3-5,10-13,16,19-20H,2,6-9,14-15,17H2,1H3,(H,39,40)/t19-,20-,26? RBSDOGUANWMYHD-NMUBWLRRSA-N 253496 US9458171, 456 Nuclear receptor ROR-gamma [262-507] 59 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253496 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253496&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217894 346547860 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440998 CC(C)c1cccc(c1)S(=O)(=O)C1(CCN(C1)C(=O)[C@H]1CC[C@@H](CC1)C(O)=O)c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F InChI=1S/C30H32F7NO5S/c1-18(2)21-4-3-5-24(16-21)44(42,43)27(14-15-38(17-27)25(39)19-6-8-20(9-7-19)26(40)41)22-10-12-23(13-11-22)28(31,29(32,33)34)30(35,36)37/h3-5,10-13,16,18-20H,6-9,14-15,17H2,1-2H3,(H,40,41)/t19-,20-,27? HKERVVQWWNPEJN-DKFXBIDSSA-N 253497 US9458171, 457 Nuclear receptor ROR-gamma [262-507] 43 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253497 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253497&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217895 346547861 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 440999 CCCc1cccc(c1)S(=O)(=O)C1(CCN(C1)C(=O)[C@H]1CC[C@@H](CC1)C(O)=O)c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F InChI=1S/C30H32F7NO5S/c1-2-4-19-5-3-6-24(17-19)44(42,43)27(15-16-38(18-27)25(39)20-7-9-21(10-8-20)26(40)41)22-11-13-23(14-12-22)28(31,29(32,33)34)30(35,36)37/h3,5-6,11-14,17,20-21H,2,4,7-10,15-16,18H2,1H3,(H,40,41)/t20-,21-,27? PQOCMQDLXHITDI-DDLDZWDOSA-N 253498 US9458171, 458 Nuclear receptor ROR-gamma [262-507] 74 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253498 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253498&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217896 346547862 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 441000 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CCC(C1)(c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1cccc(c1)C1CCCC1 InChI=1S/C32H34F7NO5S/c33-30(31(34,35)36,32(37,38)39)25-14-12-24(13-15-25)29(46(44,45)26-7-3-6-23(18-26)20-4-1-2-5-20)16-17-40(19-29)27(41)21-8-10-22(11-9-21)28(42)43/h3,6-7,12-15,18,20-22H,1-2,4-5,8-11,16-17,19H2,(H,42,43)/t21-,22-,29? ZVVJYOQJMOHCSA-FKCXMHPPSA-N 253499 US9458171, 459 Nuclear receptor ROR-gamma [262-507] 109 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253499 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253499&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217897 346547863 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 441001 CC(C)Cc1cccc(c1)S(=O)(=O)C1(CCN(C1)C(=O)[C@H]1CC[C@@H](CC1)C(O)=O)c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F InChI=1S/C31H34F7NO5S/c1-19(2)16-20-4-3-5-25(17-20)45(43,44)28(14-15-39(18-28)26(40)21-6-8-22(9-7-21)27(41)42)23-10-12-24(13-11-23)29(32,30(33,34)35)31(36,37)38/h3-5,10-13,17,19,21-22H,6-9,14-16,18H2,1-2H3,(H,41,42)/t21-,22-,28? WYPFCFKFBQBBOK-TUNMPCEVSA-N 253500 US9458171, 460 Nuclear receptor ROR-gamma [262-507] 79 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253500 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253500&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217898 346547864 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 441002 COCCCc1cccc(c1)S(=O)(=O)C1(CCN(C1)C(=O)[C@H]1CC[C@@H](CC1)C(O)=O)c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F InChI=1S/C31H34F7NO6S/c1-45-17-3-5-20-4-2-6-25(18-20)46(43,44)28(15-16-39(19-28)26(40)21-7-9-22(10-8-21)27(41)42)23-11-13-24(14-12-23)29(32,30(33,34)35)31(36,37)38/h2,4,6,11-14,18,21-22H,3,5,7-10,15-17,19H2,1H3,(H,41,42)/t21-,22-,28? DDWZZDYOPGKLJK-TUNMPCEVSA-N 253501 US9458171, 461 Nuclear receptor ROR-gamma [262-507] 270 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253501 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253501&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217902 346547865 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 441003 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CCC(C1)(c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1cccc(c1)C1CCOCC1 InChI=1S/C32H34F7NO6S/c33-30(31(34,35)36,32(37,38)39)25-10-8-24(9-11-25)29(14-15-40(19-29)27(41)21-4-6-22(7-5-21)28(42)43)47(44,45)26-3-1-2-23(18-26)20-12-16-46-17-13-20/h1-3,8-11,18,20-22H,4-7,12-17,19H2,(H,42,43)/t21-,22-,29? YCDJGUFMFSDCQE-FKCXMHPPSA-N 253502 US9458171, 462 Nuclear receptor ROR-gamma [262-507] 109 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253502 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253502&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217899 346547866 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 441004 CC(c1cccc(c1)S(=O)(=O)C1(CCN(C1)C(=O)[C@H]1CC[C@@H](CC1)C(O)=O)c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)C(F)(F)F InChI=1S/C30H29F10NO5S/c1-17(28(32,33)34)20-3-2-4-23(15-20)47(45,46)26(13-14-41(16-26)24(42)18-5-7-19(8-6-18)25(43)44)21-9-11-22(12-10-21)27(31,29(35,36)37)30(38,39)40/h2-4,9-12,15,17-19H,5-8,13-14,16H2,1H3,(H,43,44)/t17?,18-,19-,26? FGJVJBKUBUOWFJ-KXACYGKMSA-N 253503 US9458171, 463 Nuclear receptor ROR-gamma [262-507] 115 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253503 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253503&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217903 346547867 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 441005 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CCC(C1)(c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1cccc(Br)c1 InChI=1S/C27H25BrF7NO5S/c28-20-2-1-3-21(14-20)42(40,41)24(12-13-36(15-24)22(37)16-4-6-17(7-5-16)23(38)39)18-8-10-19(11-9-18)25(29,26(30,31)32)27(33,34)35/h1-3,8-11,14,16-17H,4-7,12-13,15H2,(H,38,39)/t16-,17-,24? GSKSBXMGHHICAW-CCERHYJRSA-N 253504 US9458171, 464 Nuclear receptor ROR-gamma [262-507] 184 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253504 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253504&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118208163 346547868 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 441006 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CCC(C1)(c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1cccc(Cl)c1 InChI=1S/C27H25ClF7NO5S/c28-20-2-1-3-21(14-20)42(40,41)24(12-13-36(15-24)22(37)16-4-6-17(7-5-16)23(38)39)18-8-10-19(11-9-18)25(29,26(30,31)32)27(33,34)35/h1-3,8-11,14,16-17H,4-7,12-13,15H2,(H,38,39)/t16-,17-,24? POYSKJKTKCEOFR-CCERHYJRSA-N 253505 US9458171, 465 Nuclear receptor ROR-gamma [262-507] 58 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253505 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253505&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118207913 346547869 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 441007 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CCC(C1)(c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1cccc(c1)C#N InChI=1S/C28H25F7N2O5S/c29-26(27(30,31)32,28(33,34)35)21-10-8-20(9-11-21)25(43(41,42)22-3-1-2-17(14-22)15-36)12-13-37(16-25)23(38)18-4-6-19(7-5-18)24(39)40/h1-3,8-11,14,18-19H,4-7,12-13,16H2,(H,39,40)/t18-,19-,25? XAUYVUTXBASCCT-DFPMAXHOSA-N 253506 US9458171, 466 Nuclear receptor ROR-gamma [262-507] 1048 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253506 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253506&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118208128 346547870 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 441008 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CCC(C1)(c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1cccc(O)c1 InChI=1S/C27H26F7NO6S/c28-25(26(29,30)31,27(32,33)34)19-10-8-18(9-11-19)24(42(40,41)21-3-1-2-20(36)14-21)12-13-35(15-24)22(37)16-4-6-17(7-5-16)23(38)39/h1-3,8-11,14,16-17,36H,4-7,12-13,15H2,(H,38,39)/t16-,17-,24? LKDWAHXIKKOUDH-CCERHYJRSA-N 253507 US9458171, 467 Nuclear receptor ROR-gamma [262-507] 471 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253507 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253507&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118207962 346547871 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 441009 COc1cccc(c1)S(=O)(=O)C1(CCN(C1)C(=O)[C@H]1CC[C@@H](CC1)C(O)=O)c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F InChI=1S/C28H28F7NO6S/c1-42-21-3-2-4-22(15-21)43(40,41)25(13-14-36(16-25)23(37)17-5-7-18(8-6-17)24(38)39)19-9-11-20(12-10-19)26(29,27(30,31)32)28(33,34)35/h2-4,9-12,15,17-18H,5-8,13-14,16H2,1H3,(H,38,39)/t17-,18-,25? JXAKXGZMERKCMN-QSXQOXNQSA-N 253508 US9458171, 468 Nuclear receptor ROR-gamma [262-507] 117 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253508 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253508&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118208197 346547872 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 441010 CC[C@@]1(CC[C@@H](CC1)C(O)=O)C(=O)N1CCC(C1)(c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1cccc(C)c1 InChI=1S/C30H32F7NO5S/c1-3-26(13-11-20(12-14-26)24(39)40)25(41)38-16-15-27(18-38,44(42,43)23-6-4-5-19(2)17-23)21-7-9-22(10-8-21)28(31,29(32,33)34)30(35,36)37/h4-10,17,20H,3,11-16,18H2,1-2H3,(H,39,40)/t20-,26-,27? MZCNSFXVWNSJIK-OPVQIPCQSA-N 253509 US9458171, 469 Nuclear receptor ROR-gamma [262-507] 135 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253509 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253509&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118207928 346547873 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 441011 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CCC(C1)(c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1cccc(Cc2ccccc2)c1 InChI=1S/C34H32F7NO5S/c35-32(33(36,37)38,34(39,40)41)27-15-13-26(14-16-27)31(17-18-42(21-31)29(43)24-9-11-25(12-10-24)30(44)45)48(46,47)28-8-4-7-23(20-28)19-22-5-2-1-3-6-22/h1-8,13-16,20,24-25H,9-12,17-19,21H2,(H,44,45)/t24-,25-,31? NLKOASAMSOFVIB-DUJLPWPBSA-N 253510 US9458171, 470 Nuclear receptor ROR-gamma [262-507] 939 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253510 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253510&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118208115 346547874 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 441012 OCc1cccc(c1)S(=O)(=O)C1(CCN(C1)C(=O)[C@H]1CC[C@@H](CC1)C(O)=O)c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F InChI=1S/C28H28F7NO6S/c29-26(27(30,31)32,28(33,34)35)21-10-8-20(9-11-21)25(43(41,42)22-3-1-2-17(14-22)15-37)12-13-36(16-25)23(38)18-4-6-19(7-5-18)24(39)40/h1-3,8-11,14,18-19,37H,4-7,12-13,15-16H2,(H,39,40)/t18-,19-,25? AUAIGYLAYLCRPM-DFPMAXHOSA-N 253511 US9458171, 471 Nuclear receptor ROR-gamma [262-507] 2543 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253511 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253511&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118207988 346547875 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 441013 COCc1cccc(c1)S(=O)(=O)C1(CCN(C1)C(=O)[C@H]1CC[C@@H](CC1)C(O)=O)c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F InChI=1S/C29H30F7NO6S/c1-43-16-18-3-2-4-23(15-18)44(41,42)26(13-14-37(17-26)24(38)19-5-7-20(8-6-19)25(39)40)21-9-11-22(12-10-21)27(30,28(31,32)33)29(34,35)36/h2-4,9-12,15,19-20H,5-8,13-14,16-17H2,1H3,(H,39,40)/t19-,20-,26? PGTKNKQRXOVSGF-NMUBWLRRSA-N 253512 US9458171, 472 Nuclear receptor ROR-gamma [262-507] 143 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253512 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253512&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118207969 346547876 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 441014 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CCC(C1)(c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1cccc(c1)C(F)F InChI=1S/C28H26F9NO5S/c29-22(30)18-2-1-3-21(14-18)44(42,43)25(12-13-38(15-25)23(39)16-4-6-17(7-5-16)24(40)41)19-8-10-20(11-9-19)26(31,27(32,33)34)28(35,36)37/h1-3,8-11,14,16-17,22H,4-7,12-13,15H2,(H,40,41)/t16-,17-,25? UBSWSJUXWXSCCX-MLHGEARCSA-N 253513 US9458171, 473 Nuclear receptor ROR-gamma [262-507] 74 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253513 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253513&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118207994 346547877 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 441015 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CCC(C1)(c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1cccc(CC(F)F)c1 InChI=1S/C29H28F9NO5S/c30-23(31)15-17-2-1-3-22(14-17)45(43,44)26(12-13-39(16-26)24(40)18-4-6-19(7-5-18)25(41)42)20-8-10-21(11-9-20)27(32,28(33,34)35)29(36,37)38/h1-3,8-11,14,18-19,23H,4-7,12-13,15-16H2,(H,41,42)/t18-,19-,26? WWQOWBJZZJVKDB-WOOQGZDASA-N 253514 US9458171, 474 Nuclear receptor ROR-gamma [262-507] 83 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253514 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253514&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118208012 346547878 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 441016 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CCC(C1)(c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1cccc(c1)C1(O)CCC1 InChI=1S/C31H32F7NO6S/c32-29(30(33,34)35,31(36,37)38)22-11-9-21(10-12-22)28(46(44,45)24-4-1-3-23(17-24)27(43)13-2-14-27)15-16-39(18-28)25(40)19-5-7-20(8-6-19)26(41)42/h1,3-4,9-12,17,19-20,43H,2,5-8,13-16,18H2,(H,41,42)/t19-,20-,28? LISNPSULOAVPCX-KLBFEONNSA-N 253515 US9458171, 475 Nuclear receptor ROR-gamma [262-507] 2452 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253515 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253515&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118207840 346547879 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 441017 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CCC(C1)(c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1cccc(c1)C1(F)CCC1 InChI=1S/C31H31F8NO5S/c32-27(13-2-14-27)23-3-1-4-24(17-23)46(44,45)28(15-16-40(18-28)25(41)19-5-7-20(8-6-19)26(42)43)21-9-11-22(12-10-21)29(33,30(34,35)36)31(37,38)39/h1,3-4,9-12,17,19-20H,2,5-8,13-16,18H2,(H,42,43)/t19-,20-,28? IAEIWATZJQYNEW-KLBFEONNSA-N 253516 US9458171, 476 Nuclear receptor ROR-gamma [262-507] 74 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253516 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253516&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118207811 346547880 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 441018 CC(C)(F)c1cccc(c1)S(=O)(=O)C1(CCN(C1)C(=O)[C@H]1CC[C@@H](CC1)C(O)=O)c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F InChI=1S/C30H31F8NO5S/c1-26(2,31)22-4-3-5-23(16-22)45(43,44)27(14-15-39(17-27)24(40)18-6-8-19(9-7-18)25(41)42)20-10-12-21(13-11-20)28(32,29(33,34)35)30(36,37)38/h3-5,10-13,16,18-19H,6-9,14-15,17H2,1-2H3,(H,41,42)/t18-,19-,27? DOFLOUCPJZEHQO-NCDNVGARSA-N 253517 US9458171, 477 Nuclear receptor ROR-gamma [262-507] 286 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253517 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253517&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118208132 346547881 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 441019 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CCC(C1)(c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1cccc(CC(F)(F)F)c1 InChI=1S/C29H27F10NO5S/c30-26(31,32)15-17-2-1-3-22(14-17)46(44,45)25(12-13-40(16-25)23(41)18-4-6-19(7-5-18)24(42)43)20-8-10-21(11-9-20)27(33,28(34,35)36)29(37,38)39/h1-3,8-11,14,18-19H,4-7,12-13,15-16H2,(H,42,43)/t18-,19-,25? SWOBOUPOGIPMKL-DFPMAXHOSA-N 253518 US9458171, 478 Nuclear receptor ROR-gamma [262-507] 72 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253518 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253518&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118207851 346547882 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 441020 CC(C)(O)Cc1cccc(c1)S(=O)(=O)C1(CCN(C1)C(=O)[C@H]1CC[C@@H](CC1)C(O)=O)c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F InChI=1S/C31H34F7NO6S/c1-27(2,43)17-19-4-3-5-24(16-19)46(44,45)28(14-15-39(18-28)25(40)20-6-8-21(9-7-20)26(41)42)22-10-12-23(13-11-22)29(32,30(33,34)35)31(36,37)38/h3-5,10-13,16,20-21,43H,6-9,14-15,17-18H2,1-2H3,(H,41,42)/t20-,21-,28? YHNNYUPCXQLLMB-LQQNYNNYSA-N 253519 US9458171, 479 Nuclear receptor ROR-gamma [262-507] 3228 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253519 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253519&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118208069 346547883 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 441021 CC(C)(F)Cc1cccc(c1)S(=O)(=O)C1(CCN(C1)C(=O)[C@H]1CC[C@@H](CC1)C(O)=O)c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F InChI=1S/C31H33F8NO5S/c1-27(2,32)17-19-4-3-5-24(16-19)46(44,45)28(14-15-40(18-28)25(41)20-6-8-21(9-7-20)26(42)43)22-10-12-23(13-11-22)29(33,30(34,35)36)31(37,38)39/h3-5,10-13,16,20-21H,6-9,14-15,17-18H2,1-2H3,(H,42,43)/t20-,21-,28? YYTMTOACMZFPCB-LQQNYNNYSA-N 253520 US9458171, 480 Nuclear receptor ROR-gamma [262-507] 116 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253520 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253520&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118208000 346547884 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 441022 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CCC(C1)(c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1cccc(c1)C(F)(F)F InChI=1S/C28H25F10NO5S/c29-25(27(33,34)35,28(36,37)38)19-10-8-18(9-11-19)24(45(43,44)21-3-1-2-20(14-21)26(30,31)32)12-13-39(15-24)22(40)16-4-6-17(7-5-16)23(41)42/h1-3,8-11,14,16-17H,4-7,12-13,15H2,(H,41,42)/t16-,17-,24? PDCURESXUKJPMH-CCERHYJRSA-N 253521 US9458171, 481 Nuclear receptor ROR-gamma [262-507] 2705 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253521 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253521&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118208001 346547885 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 441023 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CCC(C1)(c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1cccc(c1)C(F)(F)F InChI=1S/C28H25F10NO5S/c29-25(27(33,34)35,28(36,37)38)19-10-8-18(9-11-19)24(45(43,44)21-3-1-2-20(14-21)26(30,31)32)12-13-39(15-24)22(40)16-4-6-17(7-5-16)23(41)42/h1-3,8-11,14,16-17H,4-7,12-13,15H2,(H,41,42)/t16-,17-,24? PDCURESXUKJPMH-CCERHYJRSA-N 253522 US9458171, 482 Nuclear receptor ROR-gamma [262-507] 82 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253522 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253522&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118208001 346547886 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 441024 OC(=O)C12CCC(CC1)(CC2)C(=O)N1CCC(C1)(c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1cccc(c1)C(F)(F)F InChI=1S/C30H27F10NO5S/c31-27(29(35,36)37,30(38,39)40)19-6-4-18(5-7-19)26(47(45,46)21-3-1-2-20(16-21)28(32,33)34)14-15-41(17-26)22(42)24-8-11-25(12-9-24,13-10-24)23(43)44/h1-7,16H,8-15,17H2,(H,43,44) PVAUVHZYBCCOMQ-UHFFFAOYSA-N 253523 US9458171, 483 Nuclear receptor ROR-gamma [262-507] 186 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253523 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253523&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217909 346547887 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 441025 CC[C@@]1(CC[C@@H](CC1)C(O)=O)C(=O)N1CCC(C1)(c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1cccc(c1)C(F)(F)F InChI=1S/C30H29F10NO5S/c1-2-25(12-10-18(11-13-25)23(42)43)24(44)41-15-14-26(17-41,47(45,46)22-5-3-4-21(16-22)28(32,33)34)19-6-8-20(9-7-19)27(31,29(35,36)37)30(38,39)40/h3-9,16,18H,2,10-15,17H2,1H3,(H,42,43)/t18-,25-,26? ROVGAGBHSLUQKG-MGVRTXLGSA-N 253524 US9458171, 484 Nuclear receptor ROR-gamma [262-507] 155 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253524 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253524&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217910 346547888 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 441026 Fc1ccc(cc1)S(=O)(=O)[C@]1(CCN(C1)C(=O)C1CCS(=O)(=O)CC1)c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F InChI=1S/C25H23F8NO5S2/c26-19-5-7-20(8-6-19)41(38,39)22(11-12-34(15-22)21(35)16-9-13-40(36,37)14-10-16)17-1-3-18(4-2-17)23(27,24(28,29)30)25(31,32)33/h1-8,16H,9-15H2/t22-/m0/s1 ZOHVYFFYFCNUAZ-QFIPXVFZSA-N 253525 US9458171, 485 Nuclear receptor ROR-gamma [262-507] 54 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253525 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253525&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217911 346547889 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 441027 Fc1ccc(cc1)S(=O)(=O)[C@]1(CCN(C1)C(=O)c1ccc(=O)[nH]c1)c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F 253526 US9458171, 486 Nuclear receptor ROR-gamma [262-507] 2025 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253526 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253526&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 131636482 346547890 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 441028 Fc1ccc(cc1)S(=O)(=O)[C@]1(CCN(C1)C(=O)Cc1cncs1)c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F InChI=1S/C24H18F8N2O3S2/c25-17-5-7-19(8-6-17)39(36,37)21(9-10-34(13-21)20(35)11-18-12-33-14-38-18)15-1-3-16(4-2-15)22(26,23(27,28)29)24(30,31)32/h1-8,12,14H,9-11,13H2/t21-/m0/s1 XDCUTMBIVGJCHK-NRFANRHFSA-N 253527 US9458171, 487 Nuclear receptor ROR-gamma [262-507] 293 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253527 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253527&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217913 346547891 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 441029 Cn1cc(ccc1=O)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C26H20F8N2O4S/c1-35-14-16(2-11-21(35)37)22(38)36-13-12-23(15-36,41(39,40)20-9-7-19(27)8-10-20)17-3-5-18(6-4-17)24(28,25(29,30)31)26(32,33)34/h2-11,14H,12-13,15H2,1H3/t23-/m0/s1 HBUOFUHMDLENAL-QHCPKHFHSA-N 253528 US9458171, 488 Nuclear receptor ROR-gamma [262-507] 3718 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253528 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253528&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217914 346547892 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 441030 Fc1ccc(cc1)S(=O)(=O)[C@]1(CCN(C1)C(=O)C1CCS(=O)(=O)C1)c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F InChI=1S/C24H21F8NO5S2/c25-18-5-7-19(8-6-18)40(37,38)21(10-11-33(14-21)20(34)15-9-12-39(35,36)13-15)16-1-3-17(4-2-16)22(26,23(27,28)29)24(30,31)32/h1-8,15H,9-14H2/t15?,21-/m0/s1 QABINSUJKJJFAK-FXMQYSIJSA-N 253529 US9458171, 489 Nuclear receptor ROR-gamma [262-507] 58 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253529 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253529&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217915 346547893 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 441031 Fc1ccc(cc1)S(=O)(=O)[C@@]1(CCN(C1)C(=O)C1CCS(=O)(=O)C1)c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F InChI=1S/C24H21F8NO5S2/c25-18-5-7-19(8-6-18)40(37,38)21(10-11-33(14-21)20(34)15-9-12-39(35,36)13-15)16-1-3-17(4-2-16)22(26,23(27,28)29)24(30,31)32/h1-8,15H,9-14H2/t15?,21-/m1/s1 QABINSUJKJJFAK-MZVUKIKXSA-N 253530 US9458171, 490 Nuclear receptor ROR-gamma [262-507] 133 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253530 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253530&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 131636483 346547894 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 441032 Fc1ccc(cc1)S(=O)(=O)[C@]1(CCN(C1)C(=O)C1CCNC(=O)C1)c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F InChI=1S/C25H22F8N2O4S/c26-18-5-7-19(8-6-18)40(38,39)22(10-12-35(14-22)21(37)15-9-11-34-20(36)13-15)16-1-3-17(4-2-16)23(27,24(28,29)30)25(31,32)33/h1-8,15H,9-14H2,(H,34,36)/t15?,22-/m0/s1 ZKQQDQDQBUUMSX-CEISFSOZSA-N 253531 US9458171, 491 Nuclear receptor ROR-gamma [262-507] 3665 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253531 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253531&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217916 346547895 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 441033 Fc1ccc(cc1)S(=O)(=O)[C@@]1(CCN(C1)C(=O)C1CCNC(=O)C1)c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F InChI=1S/C25H22F8N2O4S/c26-18-5-7-19(8-6-18)40(38,39)22(10-12-35(14-22)21(37)15-9-11-34-20(36)13-15)16-1-3-17(4-2-16)23(27,24(28,29)30)25(31,32)33/h1-8,15H,9-14H2,(H,34,36)/t15?,22-/m1/s1 ZKQQDQDQBUUMSX-ZZAPORBBSA-N 253532 US9458171, 492 Nuclear receptor ROR-gamma [262-507] 2054 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253532 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253532&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 131636484 346547896 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 441034 Cc1n[nH]c(C)c1CC(=O)N1CC[C@](C1)(c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 253533 US9458171, 493 Nuclear receptor ROR-gamma [262-507] 460 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253533 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253533&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217918 346547897 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 441035 CC1(CCS(=O)(=O)CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C26H25F8NO5S2/c1-22(11-14-41(37,38)15-12-22)21(36)35-13-10-23(16-35,42(39,40)20-8-6-19(27)7-9-20)17-2-4-18(5-3-17)24(28,25(29,30)31)26(32,33)34/h2-9H,10-16H2,1H3/t23-/m0/s1 IXTMSUQJALQDBC-QHCPKHFHSA-N 253534 US9458171, 494 Nuclear receptor ROR-gamma [262-507] 95 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253534 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253534&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217920 346547898 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 441036 Fc1ccc(cc1)S(=O)(=O)[C@]1(CCN(C1)C(=O)C1CCC(=O)NC1)c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F InChI=1S/C25H22F8N2O4S/c26-18-6-8-19(9-7-18)40(38,39)22(11-12-35(14-22)21(37)15-1-10-20(36)34-13-15)16-2-4-17(5-3-16)23(27,24(28,29)30)25(31,32)33/h2-9,15H,1,10-14H2,(H,34,36)/t15?,22-/m0/s1 KLLBEAUBWIZFOA-CEISFSOZSA-N 253535 US9458171, 495 Nuclear receptor ROR-gamma [262-507] 3918 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253535 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253535&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217917 346547899 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 441037 CS(=O)(=O)N1CC(C1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C24H22F8N2O5S2/c1-40(36,37)34-12-15(13-34)20(35)33-11-10-21(14-33,41(38,39)19-8-6-18(25)7-9-19)16-2-4-17(5-3-16)22(26,23(27,28)29)24(30,31)32/h2-9,15H,10-14H2,1H3/t21-/m0/s1 JPOUEXFNOOIYAK-NRFANRHFSA-N 253536 US9458171, 496 Nuclear receptor ROR-gamma [262-507] 64 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253536 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253536&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217919 346547900 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 441038 Fc1ccc(cc1)S(=O)(=O)[C@]1(CCN(C1)C(=O)C1(CCS(=O)(=O)CC1)C=C)c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F InChI=1S/C27H25F8NO5S2/c1-2-23(12-15-42(38,39)16-13-23)22(37)36-14-11-24(17-36,43(40,41)21-9-7-20(28)8-10-21)18-3-5-19(6-4-18)25(29,26(30,31)32)27(33,34)35/h2-10H,1,11-17H2/t24-/m0/s1 KMBNAGHGCKRRBQ-DEOSSOPVSA-N 253537 US9458171, 497 Nuclear receptor ROR-gamma [262-507] 65 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253537 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253537&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118208050 346547901 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 441039 Fc1ccc(cc1)S(=O)(=O)[C@]1(CCN(C1)C(=O)O[C@H]1CO[C@H]2OCC[C@@H]12)c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F InChI=1S/C26H23F8NO6S/c27-17-5-7-18(8-6-17)42(37,38)23(15-1-3-16(4-2-15)24(28,25(29,30)31)26(32,33)34)10-11-35(14-23)22(36)41-20-13-40-21-19(20)9-12-39-21/h1-8,19-21H,9-14H2/t19-,20-,21+,23-/m0/s1 UBWFNKBVHAXOEU-QXUYBEEESA-N 253538 US9458171, 498 Nuclear receptor ROR-gamma [262-507] 137 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253538 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253538&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217921 346547902 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 441040 CCC1(CCS(=O)(=O)CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C27H27F8NO5S2/c1-2-23(12-15-42(38,39)16-13-23)22(37)36-14-11-24(17-36,43(40,41)21-9-7-20(28)8-10-21)18-3-5-19(6-4-18)25(29,26(30,31)32)27(33,34)35/h3-10H,2,11-17H2,1H3/t24-/m0/s1 HQZCXDWOMVTYLT-DEOSSOPVSA-N 253539 US9458171, 499 Nuclear receptor ROR-gamma [262-507] 54 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253539 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253539&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217922 346547903 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 441041 CS(=O)(=O)N1CCC(C1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C25H24F8N2O5S2/c1-41(37,38)35-12-10-16(14-35)21(36)34-13-11-22(15-34,42(39,40)20-8-6-19(26)7-9-20)17-2-4-18(5-3-17)23(27,24(28,29)30)25(31,32)33/h2-9,16H,10-15H2,1H3/t16?,22-/m0/s1 YAXHWJCPLQDEJX-XLDIYJRPSA-N 253540 US9458171, 500 Nuclear receptor ROR-gamma [262-507] 67 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253540 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253540&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217923 346547904 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 441042 CS(=O)(=O)N1CCC(C1)C(=O)N1CC[C@@](C1)(c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C25H24F8N2O5S2/c1-41(37,38)35-12-10-16(14-35)21(36)34-13-11-22(15-34,42(39,40)20-8-6-19(26)7-9-20)17-2-4-18(5-3-17)23(27,24(28,29)30)25(31,32)33/h2-9,16H,10-15H2,1H3/t16?,22-/m1/s1 YAXHWJCPLQDEJX-VXNXSFHZSA-N 253541 US9458171, 501 Nuclear receptor ROR-gamma [262-507] 41 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253541 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253541&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 131636485 346547905 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 441043 OC1(CCS(=O)(=O)CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C25H23F8NO6S2/c26-18-5-7-19(8-6-18)42(39,40)22(9-12-34(15-22)20(35)21(36)10-13-41(37,38)14-11-21)16-1-3-17(4-2-16)23(27,24(28,29)30)25(31,32)33/h1-8,36H,9-15H2/t22-/m0/s1 YNNSWDHDROBVBW-QFIPXVFZSA-N 253542 US9458171, 502 Nuclear receptor ROR-gamma [262-507] 29 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253542 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253542&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118207841 346547906 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 441044 Fc1ccc(cc1)S(=O)(=O)[C@]1(CCN(C1)C(=O)c1cccc(Cl)c1)c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F InChI=1S/C26H18ClF8NO3S/c27-19-3-1-2-16(14-19)22(37)36-13-12-23(15-36,40(38,39)21-10-8-20(28)9-11-21)17-4-6-18(7-5-17)24(29,25(30,31)32)26(33,34)35/h1-11,14H,12-13,15H2/t23-/m0/s1 VQVXJVPGRATSCM-QHCPKHFHSA-N 253543 US9458171, 503 Nuclear receptor ROR-gamma [262-507] 3373 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253543 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253543&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217924 346547907 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 441045 COC1(CCS(=O)(=O)CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C26H25F8NO6S2/c1-41-22(11-14-42(37,38)15-12-22)21(36)35-13-10-23(16-35,43(39,40)20-8-6-19(27)7-9-20)17-2-4-18(5-3-17)24(28,25(29,30)31)26(32,33)34/h2-9H,10-16H2,1H3/t23-/m0/s1 HPMPPPHFZHTUEW-QHCPKHFHSA-N 253544 US9458171, 504 Nuclear receptor ROR-gamma [262-507] 35 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253544 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253544&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217925 346547908 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 441046 Cn1ccc(cc1=O)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C26H20F8N2O4S/c1-35-12-10-16(14-21(35)37)22(38)36-13-11-23(15-36,41(39,40)20-8-6-19(27)7-9-20)17-2-4-18(5-3-17)24(28,25(29,30)31)26(32,33)34/h2-10,12,14H,11,13,15H2,1H3/t23-/m0/s1 BTVJRCJPQDMTBM-QHCPKHFHSA-N 253545 US9458171, 505 Nuclear receptor ROR-gamma [262-507] 1727 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253545 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253545&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217926 346547909 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 441047 CS(=O)(=O)N1CCC(CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C26H26F8N2O5S2/c1-42(38,39)36-13-10-17(11-14-36)22(37)35-15-12-23(16-35,43(40,41)21-8-6-20(27)7-9-21)18-2-4-19(5-3-18)24(28,25(29,30)31)26(32,33)34/h2-9,17H,10-16H2,1H3/t23-/m0/s1 WHXSTZQJSMXRER-QHCPKHFHSA-N 253546 US9458171, 506 Nuclear receptor ROR-gamma [262-507] 122 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253546 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253546&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217927 346547910 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 441048 Fc1ccc(cc1)S(=O)(=O)[C@]1(CCN(C1)C(=O)Cc1ccnnc1)c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F InChI=1S/C25H19F8N3O3S/c26-19-5-7-20(8-6-19)40(38,39)22(10-12-36(15-22)21(37)13-16-9-11-34-35-14-16)17-1-3-18(4-2-17)23(27,24(28,29)30)25(31,32)33/h1-9,11,14H,10,12-13,15H2/t22-/m0/s1 IYSZAWCEAZECIL-QFIPXVFZSA-N 253547 US9458171, 507 Nuclear receptor ROR-gamma [262-507] 158 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253547 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253547&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217928 346547911 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 441049 Oc1cc(ccn1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C25H18F8N2O4S/c26-18-5-7-19(8-6-18)40(38,39)22(10-12-35(14-22)21(37)15-9-11-34-20(36)13-15)16-1-3-17(4-2-16)23(27,24(28,29)30)25(31,32)33/h1-9,11,13H,10,12,14H2,(H,34,36)/t22-/m0/s1 LENWYUDHHBRSCF-QFIPXVFZSA-N 253548 US9458171, 508 Nuclear receptor ROR-gamma [262-507] 1338 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253548 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253548&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217929 346547912 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 441050 Fc1ccc(cc1)S(=O)(=O)[C@]1(CCN(C1)C(=O)Cc1cncnc1)c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F InChI=1S/C25H19F8N3O3S/c26-19-5-7-20(8-6-19)40(38,39)22(9-10-36(14-22)21(37)11-16-12-34-15-35-13-16)17-1-3-18(4-2-17)23(27,24(28,29)30)25(31,32)33/h1-8,12-13,15H,9-11,14H2/t22-/m0/s1 IDSHAHAJAMJIAX-QFIPXVFZSA-N 253549 US9458171, 509 Nuclear receptor ROR-gamma [262-507] 167 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253549 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253549&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217930 346547913 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 441051 Fc1ccc(cc1)S(=O)(=O)[C@]1(CCN(C1)C(=O)Cc1cnccn1)c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F InChI=1S/C25H19F8N3O3S/c26-18-5-7-20(8-6-18)40(38,39)22(9-12-36(15-22)21(37)13-19-14-34-10-11-35-19)16-1-3-17(4-2-16)23(27,24(28,29)30)25(31,32)33/h1-8,10-11,14H,9,12-13,15H2/t22-/m0/s1 AZFIHDXUENWNJE-QFIPXVFZSA-N 253550 US9458171, 510 Nuclear receptor ROR-gamma [262-507] 457 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253550 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253550&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217931 346547914 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 441052 OC(=O)C1CCN(CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C26H24F8N2O5S/c27-19-5-7-20(8-6-19)42(40,41)23(11-14-36(15-23)22(39)35-12-9-16(10-13-35)21(37)38)17-1-3-18(4-2-17)24(28,25(29,30)31)26(32,33)34/h1-8,16H,9-15H2,(H,37,38)/t23-/m0/s1 ZJXNCGWVVZRDGK-QHCPKHFHSA-N 253551 US9458171, 511 Nuclear receptor ROR-gamma [262-507] 187 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253551 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253551&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217932 346547915 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 441053 OC(=O)C1CC2CCC(C1)N2C(=O)N1CC[C@](C1)(c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H26F8N2O5S/c29-19-5-9-22(10-6-19)44(42,43)25(17-1-3-18(4-2-17)26(30,27(31,32)33)28(34,35)36)11-12-37(15-25)24(41)38-20-7-8-21(38)14-16(13-20)23(39)40/h1-6,9-10,16,20-21H,7-8,11-15H2,(H,39,40)/t16?,20?,21?,25-/m0/s1 BGBPALYZFLJQIW-PKDLHMLKSA-N 253552 US9458171, 512 Nuclear receptor ROR-gamma [262-507] 1085 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253552 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253552&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217933 346547916 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 441054 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CC[C@@](C1)(c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C27H25F8NO5S/c28-20-9-11-21(12-10-20)42(40,41)24(13-14-36(15-24)22(37)16-1-3-17(4-2-16)23(38)39)18-5-7-19(8-6-18)25(29,26(30,31)32)27(33,34)35/h5-12,16-17H,1-4,13-15H2,(H,38,39)/t16-,17-,24-/m1/s1 AVHWMAVUUHFRKE-HOZJOUCCSA-N 253553 US9458171, 513 Nuclear receptor ROR-gamma [262-507] 1697 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253553 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253553&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217934 346547917 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 441055 OC[C@H]1CC[C@@H](CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C27H27F8NO4S/c28-21-9-11-22(12-10-21)41(39,40)24(13-14-36(16-24)23(38)18-3-1-17(15-37)2-4-18)19-5-7-20(8-6-19)25(29,26(30,31)32)27(33,34)35/h5-12,17-18,37H,1-4,13-16H2/t17-,18-,24-/m0/s1 OGSNNIRDUYYPKK-XFAGBWLFSA-N 253554 US9458171, 514 Nuclear receptor ROR-gamma [262-507] 52 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253554 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253554&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217935 346547918 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 441056 Fc1ccc(cc1)S(=O)(=O)C1(CCN(Cc2ccccc2)C1)c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F InChI=1S/C26H21F8NO2S/c27-21-10-12-22(13-11-21)38(36,37)23(14-15-35(17-23)16-18-4-2-1-3-5-18)19-6-8-20(9-7-19)24(28,25(29,30)31)26(32,33)34/h1-13H,14-17H2 POPVGYXNCKMUSW-UHFFFAOYSA-N 253555 US9458171, 515 Nuclear receptor ROR-gamma [262-507] 3780 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253555 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253555&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217936 346547919 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 441057 O[C@H]1CC[C@H](CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C26H25F8NO4S/c27-19-7-11-21(12-8-19)40(38,39)23(13-14-35(15-23)22(37)16-1-9-20(36)10-2-16)17-3-5-18(6-4-17)24(28,25(29,30)31)26(32,33)34/h3-8,11-12,16,20,36H,1-2,9-10,13-15H2/t16-,20+,23-/m0/s1 QNLMLIHRGZGZRQ-YBVWCTEOSA-N 253556 US9458171, 516 Nuclear receptor ROR-gamma [262-507] 184 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253556 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253556&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118207991 346547920 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 441058 O[C@H]1CC[C@@H](CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C26H25F8NO4S/c27-19-7-11-21(12-8-19)40(38,39)23(13-14-35(15-23)22(37)16-1-9-20(36)10-2-16)17-3-5-18(6-4-17)24(28,25(29,30)31)26(32,33)34/h3-8,11-12,16,20,36H,1-2,9-10,13-15H2/t16-,20-,23-/m0/s1 QNLMLIHRGZGZRQ-GRWTVWFQSA-N 253557 US9458171, 517 Nuclear receptor ROR-gamma [262-507] 191 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253557 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253557&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118207991 346547921 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 441059 Fc1ccc(cc1)S(=O)(=O)[C@]1(CCN(C1)C(=O)[C@@H]1CCC=CC1)c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F InChI=1S/C26H23F8NO3S/c27-20-10-12-21(13-11-20)39(37,38)23(14-15-35(16-23)22(36)17-4-2-1-3-5-17)18-6-8-19(9-7-18)24(28,25(29,30)31)26(32,33)34/h1-2,6-13,17H,3-5,14-16H2/t17-,23-/m0/s1 SFFBOQDMYMFDES-SBUREZEXSA-N 253614 US9458171, 518 Nuclear receptor ROR-gamma [262-507] 584 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253614 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253614&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 131636488 346547978 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 441060 Fc1ccc(cc1)S(=O)(=O)[C@]1(CCN(C1)C(=O)C1(F)CCS(=O)(=O)CC1)c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F InChI=1S/C25H22F9NO5S2/c26-18-5-7-19(8-6-18)42(39,40)22(9-12-35(15-22)20(36)21(27)10-13-41(37,38)14-11-21)16-1-3-17(4-2-16)23(28,24(29,30)31)25(32,33)34/h1-8H,9-15H2/t22-/m0/s1 MGPUHNPKOGQNGH-QFIPXVFZSA-N 253558 US9458171, 519 Nuclear receptor ROR-gamma [262-507] 139 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253558 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253558&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118208184 346547922 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 441061 OCC(O)C1(CCS(=O)(=O)CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C27H27F8NO7S2/c28-19-5-7-20(8-6-19)45(42,43)24(17-1-3-18(4-2-17)25(29,26(30,31)32)27(33,34)35)9-12-36(16-24)22(39)23(21(38)15-37)10-13-44(40,41)14-11-23/h1-8,21,37-38H,9-16H2/t21?,24-/m0/s1 YQKRMDKGRBAFLF-FHZUCYEKSA-N 253559 US9458171, 520 Nuclear receptor ROR-gamma [262-507] 109 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253559 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253559&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118207904 346547923 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 441062 CNC(=O)C1(CCS(=O)(=O)CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C27H26F8N2O6S2/c1-36-21(38)23(11-14-44(40,41)15-12-23)22(39)37-13-10-24(16-37,45(42,43)20-8-6-19(28)7-9-20)17-2-4-18(5-3-17)25(29,26(30,31)32)27(33,34)35/h2-9H,10-16H2,1H3,(H,36,38)/t24-/m0/s1 FIGBADDMTJYQOJ-DEOSSOPVSA-N 253560 US9458171, 521 Nuclear receptor ROR-gamma [262-507] 129 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253560 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253560&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118207940 346547924 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 441063 NC(=O)C1(CCS(=O)(=O)CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C26H24F8N2O6S2/c27-18-5-7-19(8-6-18)44(41,42)23(16-1-3-17(4-2-16)24(28,25(29,30)31)26(32,33)34)9-12-36(15-23)21(38)22(20(35)37)10-13-43(39,40)14-11-22/h1-8H,9-15H2,(H2,35,37)/t23-/m0/s1 LIGYRJHMNQSIPU-QHCPKHFHSA-N 253561 US9458171, 522 Nuclear receptor ROR-gamma [262-507] 175 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253561 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253561&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217937 346547925 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 441064 CN(C)C(=O)C1(CCS(=O)(=O)CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H28F8N2O6S2/c1-37(2)22(39)24(12-15-45(41,42)16-13-24)23(40)38-14-11-25(17-38,46(43,44)21-9-7-20(29)8-10-21)18-3-5-19(6-4-18)26(30,27(31,32)33)28(34,35)36/h3-10H,11-17H2,1-2H3/t25-/m0/s1 JJEYJNTUJYUVMT-VWLOTQADSA-N 253562 US9458171, 523 Nuclear receptor ROR-gamma [262-507] 347 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253562 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253562&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217938 346547926 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 441065 CCNC(=O)C1(CCS(=O)(=O)CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H28F8N2O6S2/c1-2-37-22(39)24(12-15-45(41,42)16-13-24)23(40)38-14-11-25(17-38,46(43,44)21-9-7-20(29)8-10-21)18-3-5-19(6-4-18)26(30,27(31,32)33)28(34,35)36/h3-10H,2,11-17H2,1H3,(H,37,39)/t25-/m0/s1 SCAROKUNRDGRHY-VWLOTQADSA-N 253563 US9458171, 524 Nuclear receptor ROR-gamma [262-507] 134 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253563 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253563&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118218352 346547927 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 441066 CCNCC1(CCS(=O)(=O)CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H30F8N2O5S2/c1-2-37-17-24(12-15-44(40,41)16-13-24)23(39)38-14-11-25(18-38,45(42,43)22-9-7-21(29)8-10-22)19-3-5-20(6-4-19)26(30,27(31,32)33)28(34,35)36/h3-10,37H,2,11-18H2,1H3/t25-/m0/s1 YSEYEJODZFQOGF-VWLOTQADSA-N 253564 US9458171, 525 Nuclear receptor ROR-gamma [262-507] 1440 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253564 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253564&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118208116 346547928 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 441067 OCC1(CCS(=O)(=O)CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C26H25F8NO6S2/c27-19-5-7-20(8-6-19)43(40,41)23(17-1-3-18(4-2-17)24(28,25(29,30)31)26(32,33)34)9-12-35(15-23)21(37)22(16-36)10-13-42(38,39)14-11-22/h1-8,36H,9-16H2/t23-/m0/s1 FGMWBGPEMWZHPH-QHCPKHFHSA-N 253615 US9458171, 526 Nuclear receptor ROR-gamma [262-507] 56 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253615 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253615&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118207954 346547979 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 441068 CCCNCC1(CCS(=O)(=O)CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C29H32F8N2O5S2/c1-2-14-38-18-25(12-16-45(41,42)17-13-25)24(40)39-15-11-26(19-39,46(43,44)23-9-7-22(30)8-10-23)20-3-5-21(6-4-20)27(31,28(32,33)34)29(35,36)37/h3-10,38H,2,11-19H2,1H3/t26-/m0/s1 OQEUMSRIDXYSGE-SANMLTNESA-N 253565 US9458171, 527 Nuclear receptor ROR-gamma [262-507] 245 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253565 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253565&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118218398 346547929 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 441069 CC(C)NCC1(CCS(=O)(=O)CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C29H32F8N2O5S2/c1-19(2)38-17-25(12-15-45(41,42)16-13-25)24(40)39-14-11-26(18-39,46(43,44)23-9-7-22(30)8-10-23)20-3-5-21(6-4-20)27(31,28(32,33)34)29(35,36)37/h3-10,19,38H,11-18H2,1-2H3/t26-/m0/s1 KWBPKGOWXKIHBQ-SANMLTNESA-N 253566 US9458171, 528 Nuclear receptor ROR-gamma [262-507] 818 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253566 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253566&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118218332 346547930 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 441070 CNCC1(CCS(=O)(=O)CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C27H28F8N2O5S2/c1-36-16-23(11-14-43(39,40)15-12-23)22(38)37-13-10-24(17-37,44(41,42)21-8-6-20(28)7-9-21)18-2-4-19(5-3-18)25(29,26(30,31)32)27(33,34)35/h2-9,36H,10-17H2,1H3/t24-/m0/s1 BBAMRSUJKFKUIU-DEOSSOPVSA-N 253567 US9458171, 529 Nuclear receptor ROR-gamma [262-507] 185 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253567 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253567&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118218334 346547931 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 441071 CN(C)CC1(CCS(=O)(=O)CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H30F8N2O5S2/c1-37(2)17-24(12-15-44(40,41)16-13-24)23(39)38-14-11-25(18-38,45(42,43)22-9-7-21(29)8-10-22)19-3-5-20(6-4-19)26(30,27(31,32)33)28(34,35)36/h3-10H,11-18H2,1-2H3/t25-/m0/s1 PMHXAHBIWLORNQ-VWLOTQADSA-N 253568 US9458171, 530 Nuclear receptor ROR-gamma [262-507] 130 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253568 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253568&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217940 346547932 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 441072 OCCNCC1(CCS(=O)(=O)CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H30F8N2O6S2/c29-21-5-7-22(8-6-21)46(43,44)25(19-1-3-20(4-2-19)26(30,27(31,32)33)28(34,35)36)9-13-38(18-25)23(40)24(17-37-12-14-39)10-15-45(41,42)16-11-24/h1-8,37,39H,9-18H2/t25-/m0/s1 XBTZQFCZAQLQNB-VWLOTQADSA-N 253569 US9458171, 531 Nuclear receptor ROR-gamma [262-507] 59 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253569 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253569&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118218333 346547933 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 441073 COC(=O)NC1(CCS(=O)(=O)CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C27H26F8N2O7S2/c1-44-22(39)36-23(11-14-45(40,41)15-12-23)21(38)37-13-10-24(16-37,46(42,43)20-8-6-19(28)7-9-20)17-2-4-18(5-3-17)25(29,26(30,31)32)27(33,34)35/h2-9H,10-16H2,1H3,(H,36,39)/t24-/m0/s1 OWNWCGTYQRITOQ-DEOSSOPVSA-N 253570 US9458171, 532 Nuclear receptor ROR-gamma [262-507] 579 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253570 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253570&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217939 346547934 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 441074 CS(=O)(=O)C1CCC(CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C27H27F8NO5S2/c1-42(38,39)21-10-2-17(3-11-21)23(37)36-15-14-24(16-36,43(40,41)22-12-8-20(28)9-13-22)18-4-6-19(7-5-18)25(29,26(30,31)32)27(33,34)35/h4-9,12-13,17,21H,2-3,10-11,14-16H2,1H3/t17?,21?,24-/m0/s1 ROJWRLPLLGYYCX-PZYUZEHPSA-N 253571 US9458171, 533 Nuclear receptor ROR-gamma [262-507] 75 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253571 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253571&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118207966 346547935 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 441075 CS(=O)(=O)C1CCC(CC1)C(=O)N1CC[C@@](C1)(c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C27H27F8NO5S2/c1-42(38,39)21-10-2-17(3-11-21)23(37)36-15-14-24(16-36,43(40,41)22-12-8-20(28)9-13-22)18-4-6-19(7-5-18)25(29,26(30,31)32)27(33,34)35/h4-9,12-13,17,21H,2-3,10-11,14-16H2,1H3/t17?,21?,24-/m1/s1 ROJWRLPLLGYYCX-INYXTNAKSA-N 253616 US9458171, 534 Nuclear receptor ROR-gamma [262-507] 246 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253616 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253616&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 131636489 346547980 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 441076 CS(=O)(=O)C1CC(C1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C25H23F8NO5S2/c1-40(36,37)20-12-15(13-20)21(35)34-11-10-22(14-34,41(38,39)19-8-6-18(26)7-9-19)16-2-4-17(5-3-16)23(27,24(28,29)30)25(31,32)33/h2-9,15,20H,10-14H2,1H3/t15?,20?,22-/m0/s1 OLHSYXOFUJBOFM-CBBPLWRESA-N 253572 US9458171, 535 Nuclear receptor ROR-gamma [262-507] 227 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253572 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253572&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217941 346547936 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 441077 CS(=O)(=O)C1CC(C1)C(=O)N1CC[C@@](C1)(c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C25H23F8NO5S2/c1-40(36,37)20-12-15(13-20)21(35)34-11-10-22(14-34,41(38,39)19-8-6-18(26)7-9-19)16-2-4-17(5-3-16)23(27,24(28,29)30)25(31,32)33/h2-9,15,20H,10-14H2,1H3/t15?,20?,22-/m1/s1 OLHSYXOFUJBOFM-GULZSTPXSA-N 253573 US9458171, 536 Nuclear receptor ROR-gamma [262-507] 117 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253573 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253573&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 131636486 346547937 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 441078 OC[C@@H]1CC(CN1C(=O)[C@H]1CC[C@@H](CC1)C(O)=O)(c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H27F8NO6S/c29-20-9-11-22(12-10-20)44(42,43)25(18-5-7-19(8-6-18)26(30,27(31,32)33)28(34,35)36)13-21(14-38)37(15-25)23(39)16-1-3-17(4-2-16)24(40)41/h5-12,16-17,21,38H,1-4,13-15H2,(H,40,41)/t16-,17-,21-,25?/m0/s1 DATRUSIZUKWQKV-YLTHOKRMSA-N 253574 US9458171, 537 Nuclear receptor ROR-gamma [262-507] 571 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253574 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253574&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118208130 346547938 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 441079 CC(C)NC(=O)[C@@H]1CC(CN1C(=O)[C@H]1CC[C@@H](CC1)C(O)=O)(c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C31H32F8N2O6S/c1-17(2)40-25(42)24-15-28(48(46,47)23-13-11-22(32)12-14-23,16-41(24)26(43)18-3-5-19(6-4-18)27(44)45)20-7-9-21(10-8-20)29(33,30(34,35)36)31(37,38)39/h7-14,17-19,24H,3-6,15-16H2,1-2H3,(H,40,42)(H,44,45)/t18-,19-,24-,28?/m0/s1 QHHYFISFJJLRQC-BLBRLZTBSA-N 253575 US9458171, 538 Nuclear receptor ROR-gamma [262-507] 2780 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253575 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253575&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118207889 346547939 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 441080 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CC[C@](C1)(c1ccc(Br)c(F)c1)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C24H24BrF2NO5S/c25-20-10-5-17(13-21(20)27)24(34(32,33)19-8-6-18(26)7-9-19)11-12-28(14-24)22(29)15-1-3-16(4-2-15)23(30)31/h5-10,13,15-16H,1-4,11-12,14H2,(H,30,31)/t15-,16-,24-/m0/s1 UZEBTQYIEYUQTK-YWTKSJFSSA-N 253576 US9458171, 539 Nuclear receptor ROR-gamma [262-507] 307 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253576 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253576&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118208135 346547940 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 441081 Cc1ccc(cc1F)[C@@]1(CCN(C1)C(=O)[C@H]1CC[C@@H](CC1)C(O)=O)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C25H27F2NO5S/c1-16-2-7-19(14-22(16)27)25(34(32,33)21-10-8-20(26)9-11-21)12-13-28(15-25)23(29)17-3-5-18(6-4-17)24(30)31/h2,7-11,14,17-18H,3-6,12-13,15H2,1H3,(H,30,31)/t17-,18-,25-/m0/s1 NOMANBXGISQTHW-RPPIVITFSA-N 253577 US9458171, 540 Nuclear receptor ROR-gamma [262-507] 687 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253577 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253577&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118208056 346547941 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 441082 OC(c1ccc(cc1F)[C@@]1(CCN(Cc2ccccc2)C1)S(=O)(=O)c1ccc(F)cc1)(C(F)(F)F)C(F)(F)F InChI=1S/C26H21F8NO3S/c27-19-7-9-20(10-8-19)39(37,38)23(12-13-35(16-23)15-17-4-2-1-3-5-17)18-6-11-21(22(28)14-18)24(36,25(29,30)31)26(32,33)34/h1-11,14,36H,12-13,15-16H2/t23-/m0/s1 UIUDLIVZJHRENV-QHCPKHFHSA-N 253578 US9458171, 541 Nuclear receptor ROR-gamma [262-507] 288 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253578 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253578&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118208121 346547942 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 441083 CC(C)(C)OC(=O)N1CC[C@](C1)(c1ccc(c(F)c1)C(O)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C24H23F8NO5S/c1-20(2,3)38-19(34)33-11-10-21(13-33,39(36,37)16-7-5-15(25)6-8-16)14-4-9-17(18(26)12-14)22(35,23(27,28)29)24(30,31)32/h4-9,12,35H,10-11,13H2,1-3H3/t21-/m0/s1 NXXWXXZMIVRHGF-NRFANRHFSA-N 253579 US9458171, 542 Nuclear receptor ROR-gamma [262-507] 80 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253579 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253579&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118208011 346547943 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 441084 COC(c1ccc(cc1F)[C@@]1(CCN(C1)C(=O)OC(C)(C)C)S(=O)(=O)c1ccc(F)cc1)(C(F)(F)F)C(F)(F)F InChI=1S/C25H25F8NO5S/c1-21(2,3)39-20(35)34-12-11-22(14-34,40(36,37)17-8-6-16(26)7-9-17)15-5-10-18(19(27)13-15)23(38-4,24(28,29)30)25(31,32)33/h5-10,13H,11-12,14H2,1-4H3/t22-/m0/s1 AZPXMDDULDUPTC-QFIPXVFZSA-N 253580 US9458171, 543 Nuclear receptor ROR-gamma [262-507] 59 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253580 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253580&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118207936 346547944 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 441085 COC(c1ccc(cc1F)[C@@]1(CCN(C1)C(=O)[C@H]1CC[C@@H](CC1)C(O)=O)S(=O)(=O)c1ccc(F)cc1)(C(F)(F)F)C(F)(F)F InChI=1S/C28H27F8NO6S/c1-43-26(27(31,32)33,28(34,35)36)21-11-6-18(14-22(21)30)25(44(41,42)20-9-7-19(29)8-10-20)12-13-37(15-25)23(38)16-2-4-17(5-3-16)24(39)40/h6-11,14,16-17H,2-5,12-13,15H2,1H3,(H,39,40)/t16-,17-,25-/m0/s1 UHMKMROEJNUKLC-TZPNTHKFSA-N 253581 US9458171, 544 Nuclear receptor ROR-gamma [262-507] 142 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253581 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253581&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118208059 346547945 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 441086 OC(=O)C12CCC(CC1)(CC2)C(=O)N1CC[C@](C1)(c1ccc(c(F)c1)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C29H26F9NO5S/c30-18-2-4-19(5-3-18)45(43,44)26(17-1-6-20(21(31)15-17)27(32,28(33,34)35)29(36,37)38)13-14-39(16-26)22(40)24-7-10-25(11-8-24,12-9-24)23(41)42/h1-6,15H,7-14,16H2,(H,41,42)/t24?,25?,26-/m0/s1 AJLOMLHFEUJYPV-WNMGUVTHSA-N 253582 US9458171, 545 Nuclear receptor ROR-gamma [262-507] 56 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253582 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253582&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118208170 346547946 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 441087 FC(F)(F)C(F)(c1ccc(cc1)C1(CCN(C1)C(=O)C1CCS(=O)(=O)CC1)S(=O)(=O)c1ccc2CCCc2c1)C(F)(F)F InChI=1S/C28H28F7NO5S2/c29-26(27(30,31)32,28(33,34)35)22-7-5-21(6-8-22)25(43(40,41)23-9-4-18-2-1-3-20(18)16-23)12-13-36(17-25)24(37)19-10-14-42(38,39)15-11-19/h4-9,16,19H,1-3,10-15,17H2 SAENAGUMWHBKHY-UHFFFAOYSA-N 253583 US9458171, 546 Nuclear receptor ROR-gamma [262-507] 202 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253583 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253583&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118207871 346547947 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 441088 Fc1ccc(cc1)S(=O)(=O)[C@]1(CCN(Cc2ccccc2)C1)c1ccc(I)c(F)c1 InChI=1S/C23H20F2INO2S/c24-19-7-9-20(10-8-19)30(28,29)23(18-6-11-22(26)21(25)14-18)12-13-27(16-23)15-17-4-2-1-3-5-17/h1-11,14H,12-13,15-16H2/t23-/m0/s1 HSPFELKFCXSWMU-QHCPKHFHSA-N 253584 US9458171, 547 Nuclear receptor ROR-gamma [262-507] 1137 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253584 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253584&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217951 346547948 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 441089 Fc1ccc(cc1)S(=O)(=O)[C@@]1(CCN(Cc2ccccc2)C1)c1ccc(I)c(F)c1 InChI=1S/C23H20F2INO2S/c24-19-7-9-20(10-8-19)30(28,29)23(18-6-11-22(26)21(25)14-18)12-13-27(16-23)15-17-4-2-1-3-5-17/h1-11,14H,12-13,15-16H2/t23-/m1/s1 HSPFELKFCXSWMU-HSZRJFAPSA-N 253585 US9458171, 548 Nuclear receptor ROR-gamma [262-507] 2524 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253585 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253585&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217953 346547949 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 441090 OC(c1ccc(cc1F)[C@]1(CCN(Cc2ccccc2)C1)S(=O)(=O)c1ccc(F)cc1)(C(F)(F)F)C(F)(F)F InChI=1S/C26H21F8NO3S/c27-19-7-9-20(10-8-19)39(37,38)23(12-13-35(16-23)15-17-4-2-1-3-5-17)18-6-11-21(22(28)14-18)24(36,25(29,30)31)26(32,33)34/h1-11,14,36H,12-13,15-16H2/t23-/m1/s1 UIUDLIVZJHRENV-HSZRJFAPSA-N 253586 US9458171, 549 Nuclear receptor ROR-gamma [262-507] 1893 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253586 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253586&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217954 346547950 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 441091 CC(=O)N1CCN(CC1)C(=O)N1CC[C@](C1)(c1ccc(c(F)c1)C(O)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C26H25F8N3O5S/c1-16(38)35-10-12-36(13-11-35)22(39)37-9-8-23(15-37,43(41,42)19-5-3-18(27)4-6-19)17-2-7-20(21(28)14-17)24(40,25(29,30)31)26(32,33)34/h2-7,14,40H,8-13,15H2,1H3/t23-/m0/s1 TXUUYKMUZDUGRM-QHCPKHFHSA-N 253587 US9458171, 550 Nuclear receptor ROR-gamma [262-507] 40 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253587 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253587&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217955 346547951 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 441092 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CC[C@](C1)(c1ccc(c(F)c1)C(O)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C27H25F8NO6S/c28-18-6-8-19(9-7-18)43(41,42)24(11-12-36(14-24)22(37)15-1-3-16(4-2-15)23(38)39)17-5-10-20(21(29)13-17)25(40,26(30,31)32)27(33,34)35/h5-10,13,15-16,40H,1-4,11-12,14H2,(H,38,39)/t15-,16-,24-/m0/s1 PQADDPZXVHWFCR-YWTKSJFSSA-N 253588 US9458171, 551 Nuclear receptor ROR-gamma [262-507] 195 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253588 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253588&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217956 346547952 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 441093 OC(c1ccc(cc1F)[C@@]1(CCN(C1)C(=O)C1CCS(=O)(=O)CC1)S(=O)(=O)c1ccc(F)cc1)(C(F)(F)F)C(F)(F)F InChI=1S/C25H23F8NO6S2/c26-17-2-4-18(5-3-17)42(39,40)22(9-10-34(14-22)21(35)15-7-11-41(37,38)12-8-15)16-1-6-19(20(27)13-16)23(36,24(28,29)30)25(31,32)33/h1-6,13,15,36H,7-12,14H2/t22-/m0/s1 KXWYARAAXXVYOW-QFIPXVFZSA-N 253589 US9458171, 552 Nuclear receptor ROR-gamma [262-507] 101 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253589 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253589&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217959 346547953 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 441094 CC[C@@]1(CC[C@@H](CC1)C(O)=O)C(=O)N1CC[C@](C1)(c1ccc(c(F)c1)C(O)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C29H29F8NO6S/c1-2-25(11-9-17(10-12-25)23(39)40)24(41)38-14-13-26(16-38,45(43,44)20-6-4-19(30)5-7-20)18-3-8-21(22(31)15-18)27(42,28(32,33)34)29(35,36)37/h3-8,15,17,42H,2,9-14,16H2,1H3,(H,39,40)/t17-,25-,26-/m0/s1 DTAUPXDFUSPIII-ODKGLIOUSA-N 253590 US9458171, 553 Nuclear receptor ROR-gamma [262-507] 91 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253590 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253590&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217957 346547954 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 441095 CC(C)N1CC[C@](C1)(c1ccc(c(F)c1)C(O)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C22H21F8NO3S/c1-13(2)31-10-9-19(12-31,35(33,34)16-6-4-15(23)5-7-16)14-3-8-17(18(24)11-14)20(32,21(25,26)27)22(28,29)30/h3-8,11,13,32H,9-10,12H2,1-2H3/t19-/m0/s1 TVHOHBRQSLQCQK-IBGZPJMESA-N 253591 US9458171, 554 Nuclear receptor ROR-gamma [262-507] 915 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253591 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253591&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217958 346547955 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 441096 CC(=O)N1CCN(CC1)C(=O)N1CC[C@](C1)(c1ccc(c(F)c1)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C26H24F9N3O4S/c1-16(39)36-10-12-37(13-11-36)22(40)38-9-8-23(15-38,43(41,42)19-5-3-18(27)4-6-19)17-2-7-20(21(28)14-17)24(29,25(30,31)32)26(33,34)35/h2-7,14H,8-13,15H2,1H3/t23-/m0/s1 JVEDRBWKUYJJEY-QHCPKHFHSA-N 253592 US9458171, 555 Nuclear receptor ROR-gamma [262-507] 81 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253592 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253592&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217962 346547956 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 441097 CC[C@@]1(CC[C@@H](CC1)C(O)=O)C(=O)N1CC[C@](C1)(c1ccc(c(F)c1)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C29H28F9NO5S/c1-2-25(11-9-17(10-12-25)23(40)41)24(42)39-14-13-26(16-39,45(43,44)20-6-4-19(30)5-7-20)18-3-8-21(22(31)15-18)27(32,28(33,34)35)29(36,37)38/h3-8,15,17H,2,9-14,16H2,1H3,(H,40,41)/t17-,25-,26-/m0/s1 UDXDBKJGYHZKOZ-ODKGLIOUSA-N 253593 US9458171, 556 Nuclear receptor ROR-gamma [262-507] 66 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253593 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253593&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217960 346547957 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 441098 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CC[C@](C1)(c1ccc(c(F)c1)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C27H24F9NO5S/c28-18-6-8-19(9-7-18)43(41,42)24(11-12-37(14-24)22(38)15-1-3-16(4-2-15)23(39)40)17-5-10-20(21(29)13-17)25(30,26(31,32)33)27(34,35)36/h5-10,13,15-16H,1-4,11-12,14H2,(H,39,40)/t15-,16-,24-/m0/s1 IQWUYQVIXNNDQL-YWTKSJFSSA-N 253594 US9458171, 557 Nuclear receptor ROR-gamma [262-507] 51 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253594 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253594&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217964 346547958 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 441099 Fc1ccc(cc1)S(=O)(=O)[C@]1(CCN(C1)C(=O)Cc1ccncc1)c1ccc(c(F)c1)C(F)(C(F)(F)F)C(F)(F)F InChI=1S/C26H19F9N2O3S/c27-18-2-4-19(5-3-18)41(39,40)23(9-12-37(15-23)22(38)13-16-7-10-36-11-8-16)17-1-6-20(21(28)14-17)24(29,25(30,31)32)26(33,34)35/h1-8,10-11,14H,9,12-13,15H2/t23-/m0/s1 JFWQGHDCIPKIHG-QHCPKHFHSA-N 253595 US9458171, 558 Nuclear receptor ROR-gamma [262-507] 66 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253595 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253595&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217961 346547959 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 441100 Fc1ccc(cc1)S(=O)(=O)[C@]1(CCN(C1)C(=O)Cc1ccnnc1)c1ccc(c(F)c1)C(F)(C(F)(F)F)C(F)(F)F InChI=1S/C25H18F9N3O3S/c26-17-2-4-18(5-3-17)41(39,40)22(8-10-37(14-22)21(38)11-15-7-9-35-36-13-15)16-1-6-19(20(27)12-16)23(28,24(29,30)31)25(32,33)34/h1-7,9,12-13H,8,10-11,14H2/t22-/m0/s1 SZPITKUBUWCABB-QFIPXVFZSA-N 253596 US9458171, 559 Nuclear receptor ROR-gamma [262-507] 131 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253596 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253596&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217963 346547960 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 441101 Fc1ccc(cc1)S(=O)(=O)[C@]1(CCN(C1)C(=O)C1CCS(=O)(=O)CC1)c1ccc(c(F)c1)C(F)(C(F)(F)F)C(F)(F)F InChI=1S/C25H22F9NO5S2/c26-17-2-4-18(5-3-17)42(39,40)22(9-10-35(14-22)21(36)15-7-11-41(37,38)12-8-15)16-1-6-19(20(27)13-16)23(28,24(29,30)31)25(32,33)34/h1-6,13,15H,7-12,14H2/t22-/m0/s1 GPTSOWDZPNFQAG-QFIPXVFZSA-N 253597 US9458171, 560 Nuclear receptor ROR-gamma [262-507] 59 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253597 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253597&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217965 346547961 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 441102 COC(c1ccc(cc1F)[C@@]1(CCN(C1)C(=O)N1CCN(CC1)C(C)=O)S(=O)(=O)c1ccc(F)cc1)(C(F)(F)F)C(F)(F)F InChI=1S/C27H27F8N3O5S/c1-17(39)36-11-13-37(14-12-36)23(40)38-10-9-24(16-38,44(41,42)20-6-4-19(28)5-7-20)18-3-8-21(22(29)15-18)25(43-2,26(30,31)32)27(33,34)35/h3-8,15H,9-14,16H2,1-2H3/t24-/m0/s1 HBNDPFPPYUEHLV-DEOSSOPVSA-N 253598 US9458171, 561 Nuclear receptor ROR-gamma [262-507] 50 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253598 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253598&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217966 346547962 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 441103 COC(c1ccc(cc1F)[C@@]1(CCN(C1)C(=O)C1CCS(=O)(=O)CC1)S(=O)(=O)c1ccc(F)cc1)(C(F)(F)F)C(F)(F)F InChI=1S/C26H25F8NO6S2/c1-41-24(25(29,30)31,26(32,33)34)20-7-2-17(14-21(20)28)23(43(39,40)19-5-3-18(27)4-6-19)10-11-35(15-23)22(36)16-8-12-42(37,38)13-9-16/h2-7,14,16H,8-13,15H2,1H3/t23-/m0/s1 FMHQQWKKZCFOLV-QHCPKHFHSA-N 253599 US9458171, 562 Nuclear receptor ROR-gamma [262-507] 46 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253599 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253599&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217967 346547963 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 441104 COC(c1ccc(cc1F)[C@@]1(CCN(C1)C(=O)C12CCC(CC1)(CC2)C(O)=O)S(=O)(=O)c1ccc(F)cc1)(C(F)(F)F)C(F)(F)F InChI=1S/C30H29F8NO6S/c1-45-28(29(33,34)35,30(36,37)38)21-7-2-18(16-22(21)32)27(46(43,44)20-5-3-19(31)4-6-20)14-15-39(17-27)23(40)25-8-11-26(12-9-25,13-10-25)24(41)42/h2-7,16H,8-15,17H2,1H3,(H,41,42)/t25?,26?,27-/m0/s1 DDUIOYBHAIECFZ-RCSZBHJWSA-N 253600 US9458171, 563 Nuclear receptor ROR-gamma [262-507] 68 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253600 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253600&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118218385 346547964 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 441105 CCOC(c1ccc(cc1F)[C@@]1(CCN(C1)C(=O)[C@H]1CC[C@@H](CC1)C(O)=O)S(=O)(=O)c1ccc(F)cc1)(C(F)(F)F)C(F)(F)F InChI=1S/C29H29F8NO6S/c1-2-44-27(28(32,33)34,29(35,36)37)22-12-7-19(15-23(22)31)26(45(42,43)21-10-8-20(30)9-11-21)13-14-38(16-26)24(39)17-3-5-18(6-4-17)25(40)41/h7-12,15,17-18H,2-6,13-14,16H2,1H3,(H,40,41)/t17-,18-,26-/m0/s1 MKVXJMADMCUWFI-XWXLMPLOSA-N 253601 US9458171, 564 Nuclear receptor ROR-gamma [262-507] 145 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253601 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253601&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118218298 346547965 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 441106 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CC[C@](C1)(c1ccc(c(F)c1)C(OCC1CC1)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C31H31F8NO6S/c32-22-8-10-23(11-9-22)47(44,45)28(13-14-40(17-28)26(41)19-3-5-20(6-4-19)27(42)43)21-7-12-24(25(33)15-21)29(30(34,35)36,31(37,38)39)46-16-18-1-2-18/h7-12,15,18-20H,1-6,13-14,16-17H2,(H,42,43)/t19-,20-,28-/m0/s1 CLGNEXOCMVNWKD-JVAKCPTJSA-N 253602 US9458171, 565 Nuclear receptor ROR-gamma [262-507] 185 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253602 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253602&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118218299 346547966 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 441107 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CC[C@](C1)(c1ccc(c(F)c1)C(OCc1ccccc1)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C34H31F8NO6S/c35-25-11-13-26(14-12-25)50(47,48)31(16-17-43(20-31)29(44)22-6-8-23(9-7-22)30(45)46)24-10-15-27(28(36)18-24)32(33(37,38)39,34(40,41)42)49-19-21-4-2-1-3-5-21/h1-5,10-15,18,22-23H,6-9,16-17,19-20H2,(H,45,46)/t22-,23-,31-/m0/s1 UMDHHGWJHDDECM-BVXAZASISA-N 253603 US9458171, 566 Nuclear receptor ROR-gamma [262-507] 256 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253603 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253603&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118218300 346547967 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 441108 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CC[C@](C1)(c1ccc(c(F)c1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C34H29F10NO6S/c35-22-9-11-23(12-10-22)52(49,50)31(14-15-45(18-31)29(46)19-4-6-20(7-5-19)30(47)48)21-8-13-25(28(38)16-21)32(33(39,40)41,34(42,43)44)51-17-24-26(36)2-1-3-27(24)37/h1-3,8-13,16,19-20H,4-7,14-15,17-18H2,(H,47,48)/t19-,20-,31-/m0/s1 OWANMCQQMNUXGY-BPJQYFMOSA-N 253604 US9458171, 567 Nuclear receptor ROR-gamma [262-507] 188 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253604 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253604&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118218301 346547968 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 441109 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CC[C@](C1)(c1ccc(C2CC2)c(F)c1)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C27H29F2NO5S/c28-21-8-10-22(11-9-21)36(34,35)27(20-7-12-23(17-1-2-17)24(29)15-20)13-14-30(16-27)25(31)18-3-5-19(6-4-18)26(32)33/h7-12,15,17-19H,1-6,13-14,16H2,(H,32,33)/t18-,19-,27-/m0/s1 XJTHMUWNSRVDQS-BATDWUPUSA-N 253605 US9458171, 568 Nuclear receptor ROR-gamma [262-507] 95 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253605 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253605&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217973 346547969 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 441110 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CC[C@](C1)(c1ccc(c(F)c1)-c1ccccc1)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C30H29F2NO5S/c31-24-11-13-25(14-12-24)39(37,38)30(23-10-15-26(27(32)18-23)20-4-2-1-3-5-20)16-17-33(19-30)28(34)21-6-8-22(9-7-21)29(35)36/h1-5,10-15,18,21-22H,6-9,16-17,19H2,(H,35,36)/t21-,22-,30-/m0/s1 TXAUIHFAQUKJDZ-PWWNZBMUSA-N 253606 US9458171, 569 Nuclear receptor ROR-gamma [262-507] 92 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253606 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253606&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217976 346547970 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 441111 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CCC(C1)(c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc2CCCc2c1 InChI=1S/C30H30F7NO5S/c31-28(29(32,33)34,30(35,36)37)23-11-9-22(10-12-23)27(44(42,43)24-13-8-18-2-1-3-21(18)16-24)14-15-38(17-27)25(39)19-4-6-20(7-5-19)26(40)41/h8-13,16,19-20H,1-7,14-15,17H2,(H,40,41)/t19-,20-,27? AYXNCUFXJQEDDS-DKFXBIDSSA-N 253607 US9458171, 570 Nuclear receptor ROR-gamma [262-507] 1177 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253607 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253607&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217974 346547971 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 441112 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CCC(C1)(c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc2CCCc2c1 InChI=1S/C30H30F7NO5S/c31-28(29(32,33)34,30(35,36)37)23-11-9-22(10-12-23)27(44(42,43)24-13-8-18-2-1-3-21(18)16-24)14-15-38(17-27)25(39)19-4-6-20(7-5-19)26(40)41/h8-13,16,19-20H,1-7,14-15,17H2,(H,40,41)/t19-,20-,27? AYXNCUFXJQEDDS-DKFXBIDSSA-N 253608 US9458171, 571 Nuclear receptor ROR-gamma [262-507] 68 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253608 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253608&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217974 346547972 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 441113 OC(=O)[C@]12CC[C@@](CC1)(CC2)C(=O)N1CCC(C1)(c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc2CCCc2c1 InChI=1S/C32H32F7NO5S/c33-30(31(34,35)36,32(37,38)39)23-7-5-22(6-8-23)29(46(44,45)24-9-4-20-2-1-3-21(20)18-24)16-17-40(19-29)25(41)27-10-13-28(14-11-27,15-12-27)26(42)43/h4-9,18H,1-3,10-17,19H2,(H,42,43)/t27-,28-,29? VKLPVKVGBHIFLE-WKZPZDPQSA-N 253609 US9458171, 572 Nuclear receptor ROR-gamma [262-507] 211 25.00 C US Patent 10.7270/Q2NK3CZM aid1803533 US9458171 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253609 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253609&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118217975 346547973 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 509427 OC(=O)c1ccc(cc1)-c1nc(C(=O)c2c(Cl)cccc2Cl)n2ccccc12 InChI=1S/C21H12Cl2N2O3/c22-14-4-3-5-15(23)17(14)19(26)20-24-18(16-6-1-2-11-25(16)20)12-7-9-13(10-8-12)21(27)28/h1-11H,(H,27,28) BZVIPZWRCDMIKL-UHFFFAOYSA-N 268402 4-(3-(2,6-Dichlorobenzoyl)imidazo[1,5-a]pyridin-1-yl)benzoic acid::US9550771, Example 1 Nuclear receptor ROR-gamma [262-507] 26.0 25.00 C US Patent 10.7270/Q2417036 aid1795379 US9550771 Fauber, B; Gobbi, A Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=268402 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=268402&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117964982 377007262 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 509428 OC(=O)c1ccc(cc1)-c1nc(Sc2c(Cl)cccc2Cl)n2ccccc12 InChI=1S/C20H12Cl2N2O2S/c21-14-4-3-5-15(22)18(14)27-20-23-17(16-6-1-2-11-24(16)20)12-7-9-13(10-8-12)19(25)26/h1-11H,(H,25,26) CZVOWGMSHURFEW-UHFFFAOYSA-N 268403 4-(6-(2,6-Dichlorobenzoyl)imidazo[1,5-a]pyrimidin-8-yl)benzoic acid::US9550771, Example 2 Nuclear receptor ROR-gamma [262-507] 262 25.00 C US Patent 10.7270/Q2417036 aid1795379 US9550771 Fauber, B; Gobbi, A Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=268403 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=268403&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122529844 377007263 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 509429 OC(=O)c1ccc(-c2nc(C(=O)c3c(Cl)cccc3Cl)n3ccccc23)c(F)c1 InChI=1S/C21H11Cl2FN2O3/c22-13-4-3-5-14(23)17(13)19(27)20-25-18(16-6-1-2-9-26(16)20)12-8-7-11(21(28)29)10-15(12)24/h1-10H,(H,28,29) ZDQDIGWUQZEPKQ-UHFFFAOYSA-N 268404 4-(3-(2-(Trifluoromethyl)benzoyl)imidazo[1,5-a]pyridin-1-yl)benzoic acid::US9550771, Example 3 Nuclear receptor ROR-gamma [262-507] 8.00 25.00 C US Patent 10.7270/Q2417036 aid1795379 US9550771 Fauber, B; Gobbi, A Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=268404 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=268404&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122529829 377007264 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 509430 OC(=O)C1CCN(CC1)c1nc(C(=O)c2c(Cl)cccc2Cl)n2ccccc12 InChI=1S/C20H17Cl2N3O3/c21-13-4-3-5-14(22)16(13)17(26)19-23-18(15-6-1-2-9-25(15)19)24-10-7-12(8-11-24)20(27)28/h1-6,9,12H,7-8,10-11H2,(H,27,28) QUQIIAMZLUCJAT-UHFFFAOYSA-N 268405 4-(3-(2-(Trifluoromethyl)benzoyl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-1-yl)benzoic acid::US9550771, Example 4 Nuclear receptor ROR-gamma [262-507] 1000 25.00 C US Patent 10.7270/Q2417036 aid1795379 US9550771 Fauber, B; Gobbi, A Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=268405 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=268405&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122529859 377007265 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 509431 OC(=O)c1ccc(-c2nc(C(=O)c3ccccc3C(F)(F)F)n3ccccc23)c(F)c1 InChI=1S/C22H12F4N2O3/c23-16-11-12(21(30)31)8-9-14(16)18-17-7-3-4-10-28(17)20(27-18)19(29)13-5-1-2-6-15(13)22(24,25)26/h1-11H,(H,30,31) KYLXFVCMWJMZJG-UHFFFAOYSA-N 268406 1-(3-(2-chloro-6-(trifluoromethyl)benzoyl)imidazo[1,5-a]pyridin-1-yl)piperidine-4-carboxylic acid::US9550771, Example 5 Nuclear receptor ROR-gamma [262-507] 77.0 25.00 C US Patent 10.7270/Q2417036 aid1795379 US9550771 Fauber, B; Gobbi, A Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=268406 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=268406&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122529830 377007266 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 509432 OC(=O)c1ccc(cc1)-c1nc(C(=O)c2ccccc2C(F)(F)F)n2ccccc12 InChI=1S/C22H13F3N2O3/c23-22(24,25)16-6-2-1-5-15(16)19(28)20-26-18(17-7-3-4-12-27(17)20)13-8-10-14(11-9-13)21(29)30/h1-12H,(H,29,30) LNDNDAFLVKTHJZ-UHFFFAOYSA-N 268407 4-[3-[2- (trifluoromethyl)benzoyl]imidazo [1,5-a]pyridin-1-yl]benzoic acid::US9550771, Example 6 Nuclear receptor ROR-gamma [262-507] 179 25.00 C US Patent 10.7270/Q2417036 aid1795379 US9550771 Fauber, B; Gobbi, A Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=268407 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=268407&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117964931 377007267 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 509433 OC(=O)C1CCN(CC1)c1nc(C(=O)c2ccccc2C(F)(F)F)n2ccccc12 InChI=1S/C21H18F3N3O3/c22-21(23,24)15-6-2-1-5-14(15)17(28)19-25-18(16-7-3-4-10-27(16)19)26-11-8-13(9-12-26)20(29)30/h1-7,10,13H,8-9,11-12H2,(H,29,30) YWMNGZHTLFHANP-UHFFFAOYSA-N 268408 1-[3-[2- (trifluoromethyl)benzoyl]imidazo [1,5-a]pyridin-1-yl]piperidine-4- carboxylic acid::US9550771, Example 7 Nuclear receptor ROR-gamma [262-507] 2700 25.00 C US Patent 10.7270/Q2417036 aid1795379 US9550771 Fauber, B; Gobbi, A Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=268408 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=268408&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117964988 377007268 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 509434 OC(=O)c1ccc(cc1Cl)-c1nc(C(=O)c2ccccc2C(F)(F)F)n2ccccc12 InChI=1S/C22H12ClF3N2O3/c23-16-11-12(8-9-14(16)21(30)31)18-17-7-3-4-10-28(17)20(27-18)19(29)13-5-1-2-6-15(13)22(24,25)26/h1-11H,(H,30,31) HJMQIWTYSQWLTP-UHFFFAOYSA-N 268409 2-chloro-4-[3-[2- (trifluoromethyl)benzoyl]imidazo [1,5-a]pyridin-1-yl]benzoic acid::US9550771, Example 8 Nuclear receptor ROR-gamma [262-507] 2900 25.00 C US Patent 10.7270/Q2417036 aid1795379 US9550771 Fauber, B; Gobbi, A Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=268409 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=268409&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117964991 377007269 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 509435 OC(=O)c1ccc(-c2nc(C(=O)c3ccccc3C(F)(F)F)n3ccccc23)c(Cl)c1 InChI=1S/C22H12ClF3N2O3/c23-16-11-12(21(30)31)8-9-14(16)18-17-7-3-4-10-28(17)20(27-18)19(29)13-5-1-2-6-15(13)22(24,25)26/h1-11H,(H,30,31) XFGGAVDGHSFDBS-UHFFFAOYSA-N 268410 3-chloro-4-[3-[2- (trifluoromethyl)benzoyl]imidazo [1,5-a]pyridin-1-yl]benzoic acid::US9550771, Example 9 Nuclear receptor ROR-gamma [262-507] 496 25.00 C US Patent 10.7270/Q2417036 aid1795379 US9550771 Fauber, B; Gobbi, A Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=268410 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=268410&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117964993 377007270 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 509436 Cc1cc(ccc1-c1nc(C(=O)c2ccccc2C(F)(F)F)n2ccccc12)C(O)=O InChI=1S/C23H15F3N2O3/c1-13-12-14(22(30)31)9-10-15(13)19-18-8-4-5-11-28(18)21(27-19)20(29)16-6-2-3-7-17(16)23(24,25)26/h2-12H,1H3,(H,30,31) DOZMTDOUFLKMQN-UHFFFAOYSA-N 268411 3-methyl-4-[3-[2- (trifluoromethyl)benzoyl]imidazo [1,5-a]pyridin-1-yl]benzoic acid::US9550771, Example 10 Nuclear receptor ROR-gamma [262-507] 529 25.00 C US Patent 10.7270/Q2417036 aid1795379 US9550771 Fauber, B; Gobbi, A Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=268411 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=268411&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117965002 377007271 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 509437 OC(=O)c1ccc(cc1F)-c1nc(C(=O)c2ccccc2C(F)(F)F)n2ccccc12 InChI=1S/C22H12F4N2O3/c23-16-11-12(8-9-14(16)21(30)31)18-17-7-3-4-10-28(17)20(27-18)19(29)13-5-1-2-6-15(13)22(24,25)26/h1-11H,(H,30,31) OOPCWZZOEKEFJJ-UHFFFAOYSA-N 268412 2-fluoro-4-[3-[2- (trifluoromethyl)benzoyl]imidazo [1,5-a]pyridin-1-yl]benzoic acid::US9550771, Example 11 Nuclear receptor ROR-gamma [262-507] 486 25.00 C US Patent 10.7270/Q2417036 aid1795379 US9550771 Fauber, B; Gobbi, A Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=268412 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=268412&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117964994 377007272 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 509438 OC(=O)c1ccc(cc1O)-c1nc(C(=O)c2ccccc2C(F)(F)F)n2ccccc12 InChI=1S/C22H13F3N2O4/c23-22(24,25)15-6-2-1-5-13(15)19(29)20-26-18(16-7-3-4-10-27(16)20)12-8-9-14(21(30)31)17(28)11-12/h1-11,28H,(H,30,31) KJPIFQGPJKQLLO-UHFFFAOYSA-N 268413 2-hydroxy-4-[3-[2- (trifluoromethyl)benzoyl]imidazo [1,5-a]pyridin-1-yl]benzoic acid::US9550771, Example 12 Nuclear receptor ROR-gamma [262-507] 3.00 25.00 C US Patent 10.7270/Q2417036 aid1795379 US9550771 Fauber, B; Gobbi, A Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=268413 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=268413&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117964992 377007273 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 509439 OC(=O)c1cc(ccc1O)-c1nc(C(=O)c2ccccc2C(F)(F)F)n2ccccc12 InChI=1S/C22H13F3N2O4/c23-22(24,25)15-6-2-1-5-13(15)19(29)20-26-18(16-7-3-4-10-27(16)20)12-8-9-17(28)14(11-12)21(30)31/h1-11,28H,(H,30,31) CWVLEYMBYHXEIB-UHFFFAOYSA-N 268414 2-hydroxy-5-[3-[2- (trifluoromethyl)benzoyl]imidazo [1,5-a]pyridin-1-yl]benzoic acid::US9550771, Example 13 Nuclear receptor ROR-gamma [262-507] 6300 25.00 C US Patent 10.7270/Q2417036 aid1795379 US9550771 Fauber, B; Gobbi, A Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=268414 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=268414&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122529843 377007274 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 509440 OC(=O)c1ccc(-c2nc(C(=O)c3ccccc3C(F)(F)F)n3ccccc23)c(F)c1F InChI=1S/C22H11F5N2O3/c23-16-12(8-9-13(17(16)24)21(31)32)18-15-7-3-4-10-29(15)20(28-18)19(30)11-5-1-2-6-14(11)22(25,26)27/h1-10H,(H,31,32) INYJYMAFIREOFB-UHFFFAOYSA-N 268415 2,3-difluoro-4-[3-[2- (trifluoromethyl)benzoyl]imidazo [1,5-a]pyridin-1-yl]benzoic acid::US9550771, Example 14 Nuclear receptor ROR-gamma [262-507] 358 25.00 C US Patent 10.7270/Q2417036 aid1795379 US9550771 Fauber, B; Gobbi, A Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=268415 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=268415&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122529833 377007275 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 509441 OC(=O)c1cc(F)c(-c2nc(C(=O)c3ccccc3C(F)(F)F)n3ccccc23)c(F)c1 InChI=1S/C22H11F5N2O3/c23-14-9-11(21(31)32)10-15(24)17(14)18-16-7-3-4-8-29(16)20(28-18)19(30)12-5-1-2-6-13(12)22(25,26)27/h1-10H,(H,31,32) TYRZSXNQRHAGBN-UHFFFAOYSA-N 268416 3,5-difluoro-4-[3-[2- (trifluoromethyl)benzoyl]imidazo [1,5-a]pyridin-1-yl]benzoic acid::US9550771, Example 15 Nuclear receptor ROR-gamma [262-507] 189 25.00 C US Patent 10.7270/Q2417036 aid1795379 US9550771 Fauber, B; Gobbi, A Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=268416 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=268416&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122529826 377007276 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 509442 OC(=O)c1ccc(cc1O)-c1nc(C(=O)c2c(Cl)cccc2Cl)n2ccccc12 InChI=1S/C21H12Cl2N2O4/c22-13-4-3-5-14(23)17(13)19(27)20-24-18(15-6-1-2-9-25(15)20)11-7-8-12(21(28)29)16(26)10-11/h1-10,26H,(H,28,29) HUZGIHSCXSCKET-UHFFFAOYSA-N 268417 4-[3-(2,6- dichlorobenzoyl)imidazo[1,5 a]pyridin-1-yl]-2-hydroxy- benzoic acid::US9550771, Example 16 Nuclear receptor ROR-gamma [262-507] 3.00 25.00 C US Patent 10.7270/Q2417036 aid1795379 US9550771 Fauber, B; Gobbi, A Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=268417 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=268417&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122529855 377007277 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 509443 OC(=O)c1ccc(cc1O)-c1nc(C(=O)c2c(Cl)cccc2C(F)(F)F)n2ccccc12 InChI=1S/C22H12ClF3N2O4/c23-14-5-3-4-13(22(24,25)26)17(14)19(30)20-27-18(15-6-1-2-9-28(15)20)11-7-8-12(21(31)32)16(29)10-11/h1-10,29H,(H,31,32) UAAUZNSONHHQQI-UHFFFAOYSA-N 50106287 CHEMBL3598148::US9550771, Example 17 Nuclear receptor ROR-gamma [262-507] 2.00 25.00 C US Patent 10.7270/Q2417036 aid1795379 US9550771 Fauber, B; Gobbi, A Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50106287 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50106287&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 91664317 319492791 CHEMBL3598148 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 509444 OC(=O)c1ccc(cc1)-c1nc(C(=O)c2c(Cl)cccc2Cl)n2cccnc12 InChI=1S/C20H11Cl2N3O3/c21-13-3-1-4-14(22)15(13)17(26)19-24-16(18-23-9-2-10-25(18)19)11-5-7-12(8-6-11)20(27)28/h1-10H,(H,27,28) CNNYWBQQJARBAU-UHFFFAOYSA-N 268419 4-[6-(2,6- dichlorobenzoyl)imidazo[1,5- a]pyrimidin-8-yl]benzoic acid::US9550771, Example 18 Nuclear receptor ROR-gamma [262-507] 84.0 25.00 C US Patent 10.7270/Q2417036 aid1795379 US9550771 Fauber, B; Gobbi, A Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=268419 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=268419&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117964959 377007279 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 509445 COc1cccc(F)c1C(=O)c1nc(-c2ccc(cc2)C(O)=O)n2CCCCc12 InChI=1S/C22H19FN2O4/c1-29-17-7-4-5-15(23)18(17)20(26)19-16-6-2-3-12-25(16)21(24-19)13-8-10-14(11-9-13)22(27)28/h4-5,7-11H,2-3,6,12H2,1H3,(H,27,28) HQNLDFJZVCJINX-UHFFFAOYSA-N 268420 4-[1-(2-fluoro-6-methoxy- benzoyl)-5,6,7,8- tetrahydroimidazo[1,5-a]pyridin- 3-yl]benzoic acid::US9550771, Example 19 Nuclear receptor ROR-gamma [262-507] 4400 25.00 C US Patent 10.7270/Q2417036 aid1795379 US9550771 Fauber, B; Gobbi, A Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=268420 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=268420&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122529850 377007280 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 509446 OC(=O)c1ccc(cc1)-c1nc(C(=O)c2ccccc2C(F)(F)F)n2CCCCc12 InChI=1S/C22H17F3N2O3/c23-22(24,25)16-6-2-1-5-15(16)19(28)20-26-18(17-7-3-4-12-27(17)20)13-8-10-14(11-9-13)21(29)30/h1-2,5-6,8-11H,3-4,7,12H2,(H,29,30) NPIABGMDQLMFAY-UHFFFAOYSA-N 268421 4-[3-[2- (trifluoromethyl)benzoyl]-5,6,7,8- tetrahydroimidazo[1,5-a]pyridin- 1-yl]benzoic acid::US9550771, Example 20 Nuclear receptor ROR-gamma [262-507] 2200 25.00 C US Patent 10.7270/Q2417036 aid1795379 US9550771 Fauber, B; Gobbi, A Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=268421 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=268421&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117964957 377007281 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 509447 OC(=O)c1ccc(-c2nc(C(=O)c3c(Cl)cccc3C(F)(F)F)n3CCCCc23)c(F)c1 InChI=1S/C22H15ClF4N2O3/c23-14-5-3-4-13(22(25,26)27)17(14)19(30)20-28-18(16-6-1-2-9-29(16)20)12-8-7-11(21(31)32)10-15(12)24/h3-5,7-8,10H,1-2,6,9H2,(H,31,32) BQKPQRMICRYEPE-UHFFFAOYSA-N 50106289 CHEMBL3596270::US9550771, Example 21 Nuclear receptor ROR-gamma [262-507] 32.0 25.00 C US Patent 10.7270/Q2417036 aid1795379 US9550771 Fauber, B; Gobbi, A Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50106289 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50106289&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117964998 319492793 CHEMBL3596270 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 509448 OC(=O)c1ccc(cc1)-c1nc(C(=O)c2c(Cl)cccc2C(F)(F)F)n2CCCCc12 InChI=1S/C22H16ClF3N2O3/c23-15-5-3-4-14(22(24,25)26)17(15)19(29)20-27-18(16-6-1-2-11-28(16)20)12-7-9-13(10-8-12)21(30)31/h3-5,7-10H,1-2,6,11H2,(H,30,31) GMCJUSQYDSWBGL-UHFFFAOYSA-N 50106302 CHEMBL3598142::US9550771, Example 22 Nuclear receptor ROR-gamma [262-507] 58.0 25.00 C US Patent 10.7270/Q2417036 aid1795379 US9550771 Fauber, B; Gobbi, A Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50106302 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50106302&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117964989 319492806 CHEMBL3598142 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 509449 OC(=O)c1ccc(cc1F)-c1nc(C(=O)c2c(Cl)cccc2C(F)(F)F)n2CCCCc12 InChI=1S/C22H15ClF4N2O3/c23-14-5-3-4-13(22(25,26)27)17(14)19(30)20-28-18(16-6-1-2-9-29(16)20)11-7-8-12(21(31)32)15(24)10-11/h3-5,7-8,10H,1-2,6,9H2,(H,31,32) GKOMLTNKESYVSN-UHFFFAOYSA-N 268424 4-[3-[2-chloro-6- (trifluoromethyl)benzoyl]-5,6,7,8- tetrahydroimidazo[1,5-a]pyridin- 1-yl]-2-fluoro-benzoic acid::US9550771, Example 23 Nuclear receptor ROR-gamma [262-507] 205 25.00 C US Patent 10.7270/Q2417036 aid1795379 US9550771 Fauber, B; Gobbi, A Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=268424 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=268424&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117964999 377007284 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 509450 OC(=O)c1ccc(cc1O)-c1nc(C(=O)c2c(Cl)cccc2C(F)(F)F)n2CCCCc12 InChI=1S/C22H16ClF3N2O4/c23-14-5-3-4-13(22(24,25)26)17(14)19(30)20-27-18(15-6-1-2-9-28(15)20)11-7-8-12(21(31)32)16(29)10-11/h3-5,7-8,10,29H,1-2,6,9H2,(H,31,32) VENZMHQHEPVVMH-UHFFFAOYSA-N 268425 4-[3-[2-chloro-6- (trifluoromethyl)benzoyl]-5,6,7,8- tetrahydroimidazo[1,5-a]pyridin- 1-yl]-2-hydroxy-benzoic acid::US9550771, Example 24 Nuclear receptor ROR-gamma [262-507] 3.00 25.00 C US Patent 10.7270/Q2417036 aid1795379 US9550771 Fauber, B; Gobbi, A Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=268425 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=268425&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117965000 377007285 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 509451 OC(=O)c1ccc(-c2nc(C(=O)c3c(Cl)cccc3C(F)(F)F)n3CCCCc23)c(Cl)c1 InChI=1S/C22H15Cl2F3N2O3/c23-14-5-3-4-13(22(25,26)27)17(14)19(30)20-28-18(16-6-1-2-9-29(16)20)12-8-7-11(21(31)32)10-15(12)24/h3-5,7-8,10H,1-2,6,9H2,(H,31,32) ULNLHCGGTSMXAO-UHFFFAOYSA-N 268426 3-chloro-4-[3-[2-chloro-6- (trifluoromethyl)benzoyl]-5,6,7,8- tetrahydroimidazo[1,5-a]pyridin- 1-yl]benzoic acid::US9550771, Example 25 Nuclear receptor ROR-gamma [262-507] 171 25.00 C US Patent 10.7270/Q2417036 aid1795379 US9550771 Fauber, B; Gobbi, A Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=268426 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=268426&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117964995 377007286 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 509452 CC(=O)Oc1cc(ccc1C(O)=O)-c1nc(C(=O)c2c(Cl)cccc2C(F)(F)F)n2ccccc12 InChI=1S/C24H14ClF3N2O5/c1-12(31)35-18-11-13(8-9-14(18)23(33)34)20-17-7-2-3-10-30(17)22(29-20)21(32)19-15(24(26,27)28)5-4-6-16(19)25/h2-11H,1H3,(H,33,34) ZAQIWXNEJZRDGF-UHFFFAOYSA-N 268427 2-acetoxy-4-[3-[2-chloro-6- (trifluoromethyl)benzoyl]imidazo [1,5-a]pyridin-1-yl]benzoic acid::US9550771, Example 26 Nuclear receptor ROR-gamma [262-507] 7.00 25.00 C US Patent 10.7270/Q2417036 aid1795379 US9550771 Fauber, B; Gobbi, A Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=268427 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=268427&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117965003 377007287 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 509453 OC(=O)c1ccc(cc1)-c1nc(C(=O)c2c(Cl)cccc2C(F)(F)F)n2ccccc12 InChI=1S/C22H12ClF3N2O3/c23-15-5-3-4-14(22(24,25)26)17(15)19(29)20-27-18(16-6-1-2-11-28(16)20)12-7-9-13(10-8-12)21(30)31/h1-11H,(H,30,31) RUEKRLSPXAQNCP-UHFFFAOYSA-N 50106286 CHEMBL3598141::US9550771, Example 27 Nuclear receptor ROR-gamma [262-507] 10.00 25.00 C US Patent 10.7270/Q2417036 aid1795379 US9550771 Fauber, B; Gobbi, A Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50106286 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50106286&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117964978 319492790 CHEMBL3598141 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 509454 OC(=O)c1ccc(-c2nc(C(=O)c3c(Cl)cccc3C(F)(F)F)n3ccccc23)c(F)c1 InChI=1S/C22H11ClF4N2O3/c23-14-5-3-4-13(22(25,26)27)17(14)19(30)20-28-18(16-6-1-2-9-29(16)20)12-8-7-11(21(31)32)10-15(12)24/h1-10H,(H,31,32) LTTBADSZQZHNMO-UHFFFAOYSA-N 50106288 CHEMBL3598149::US9550771, Example 28 Nuclear receptor ROR-gamma [262-507] 9.00 25.00 C US Patent 10.7270/Q2417036 aid1795379 US9550771 Fauber, B; Gobbi, A Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50106288 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50106288&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117964962 319492792 CHEMBL3598149 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 509455 OC(=O)C1CCC(=CC1)c1nc(C(=O)c2c(Cl)cccc2C(F)(F)F)n2ccccc12 InChI=1S/C22H16ClF3N2O3/c23-15-5-3-4-14(22(24,25)26)17(15)19(29)20-27-18(16-6-1-2-11-28(16)20)12-7-9-13(10-8-12)21(30)31/h1-7,11,13H,8-10H2,(H,30,31) PVQJAHJILZAYMT-UHFFFAOYSA-N 50106325 CHEMBL3598150::US9550771, Example 29 Nuclear receptor ROR-gamma [262-507] 103 25.00 C US Patent 10.7270/Q2417036 aid1795379 US9550771 Fauber, B; Gobbi, A Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50106325 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50106325&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 10958231 104001880 CHEMBL3598150 ZINC13470082 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 509456 OC(=O)C1CCN(CC1)c1nc(C(=O)c2c(Cl)cccc2C(F)(F)F)n2ccccc12 InChI=1S/C21H17ClF3N3O3/c22-14-5-3-4-13(21(23,24)25)16(14)17(29)19-26-18(15-6-1-2-9-28(15)19)27-10-7-12(8-11-27)20(30)31/h1-6,9,12H,7-8,10-11H2,(H,30,31) GMKDGMOOAQPPOB-UHFFFAOYSA-N 50106326 CHEMBL3598153::US9550771, Example 30 Nuclear receptor ROR-gamma [262-507] 539 25.00 C US Patent 10.7270/Q2417036 aid1795379 US9550771 Fauber, B; Gobbi, A Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50106326 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50106326&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 11564613 104001881 CHEMBL3598153 ZINC12370211 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 509457 CC#Cc1cccc(Cl)c1C(=O)c1nc(-c2ccc(cc2)C(O)=O)c2ccccn12 InChI=1S/C24H15ClN2O3/c1-2-6-15-7-5-8-18(25)20(15)22(28)23-26-21(19-9-3-4-14-27(19)23)16-10-12-17(13-11-16)24(29)30/h3-5,7-14H,1H3,(H,29,30) CWOSGIROISSPTK-UHFFFAOYSA-N 268432 4-[3-(2-chloro-6-prop-1-ynyl- benzoyl)imidazo[1,5-a]pyridin-1- yl]benzoic acid::US9550771, Example 31 Nuclear receptor ROR-gamma [262-507] 202 25.00 C US Patent 10.7270/Q2417036 aid1795379 US9550771 Fauber, B; Gobbi, A Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=268432 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=268432&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117964979 377007292 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 509458 OC(=O)c1ccc(cc1)-c1nc(C(=O)c2c(Cl)cccc2C#CC2CC2)n2ccccc12 InChI=1S/C26H17ClN2O3/c27-20-5-3-4-17(10-9-16-7-8-16)22(20)24(30)25-28-23(21-6-1-2-15-29(21)25)18-11-13-19(14-12-18)26(31)32/h1-6,11-16H,7-8H2,(H,31,32) YIBFLPUJTLRJPL-UHFFFAOYSA-N 268433 4-[3-[2-chloro-6-(2- cyclopropylethynyl)benzoyl] imidazo[1,5-a]pyridin-1-yl] benzoic acid::US9550771, Example 32 Nuclear receptor ROR-gamma [262-507] 191 25.00 C US Patent 10.7270/Q2417036 aid1795379 US9550771 Fauber, B; Gobbi, A Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=268433 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=268433&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117964966 377007293 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 509459 OC(=O)C1(F)CCN(CC1)c1nc(C(=O)c2c(Cl)cccc2C(F)(F)F)n2ccccc12 InChI=1S/C21H16ClF4N3O3/c22-13-5-3-4-12(21(24,25)26)15(13)16(30)18-27-17(14-6-1-2-9-29(14)18)28-10-7-20(23,8-11-28)19(31)32/h1-6,9H,7-8,10-11H2,(H,31,32) GPEHHJBKXXAPAX-UHFFFAOYSA-N 268434 1-[3-[2-chloro-6- (trifluoromethyl)benzoyl]imidazo [1,5-a]pyridin-1-yl]-4-fluoro- piperidine-4-carboxylic acid::US9550771, Example 33 Nuclear receptor ROR-gamma [262-507] 1300 25.00 C US Patent 10.7270/Q2417036 aid1795379 US9550771 Fauber, B; Gobbi, A Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=268434 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=268434&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122529827 377007294 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 509460 OC(=O)c1ccc(cc1)-c1nc(C(=O)c2c(Cl)cccc2C2CC2)n2ccccc12 InChI=1S/C24H17ClN2O3/c25-18-5-3-4-17(14-7-8-14)20(18)22(28)23-26-21(19-6-1-2-13-27(19)23)15-9-11-16(12-10-15)24(29)30/h1-6,9-14H,7-8H2,(H,29,30) QLPYRJMIYCGJEV-UHFFFAOYSA-N 268435 4-[3-(2-chloro-6-cyclopropyl- benzoyl)imidazo[1,5-a]pyridin-1- yl]benzoic acid::US9550771, Example 34 Nuclear receptor ROR-gamma [262-507] 9.00 25.00 C US Patent 10.7270/Q2417036 aid1795379 US9550771 Fauber, B; Gobbi, A Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=268435 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=268435&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122529831 377007295 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 509461 OC(=O)C1CCC(=CC1)c1nc(C(=O)c2c(Cl)cccc2C2CC2)n2ccccc12 InChI=1S/C24H21ClN2O3/c25-18-5-3-4-17(14-7-8-14)20(18)22(28)23-26-21(19-6-1-2-13-27(19)23)15-9-11-16(12-10-15)24(29)30/h1-6,9,13-14,16H,7-8,10-12H2,(H,29,30) BGZZGZSCNJVLLB-UHFFFAOYSA-N 268436 4-[3-(2-chloro-6-cyclopropyl- benzoyl)imidazo[1,5-a]pyridin-1- yl]cyclohex-3-ene-1-carboxylic acid::US9550771, Example 35 Nuclear receptor ROR-gamma [262-507] 45.0 25.00 C US Patent 10.7270/Q2417036 aid1795379 US9550771 Fauber, B; Gobbi, A Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=268436 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=268436&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122529847 377007296 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 509462 OC(=O)C1CCN(CC1)c1nc(C(=O)c2c(Cl)cccc2C2CC2)n2ccccc12 InChI=1S/C23H22ClN3O3/c24-17-5-3-4-16(14-7-8-14)19(17)20(28)22-25-21(18-6-1-2-11-27(18)22)26-12-9-15(10-13-26)23(29)30/h1-6,11,14-15H,7-10,12-13H2,(H,29,30) TYDBOGPZWVFMSW-UHFFFAOYSA-N 268437 1-[3-(2-chloro-6-cyclopropyl- benzoyl)imidazo[1,5-a]pyridin-1- yl]piperidine-4-carboxylic acid::US9550771, Example 36 Nuclear receptor ROR-gamma [262-507] 368 25.00 C US Patent 10.7270/Q2417036 aid1795379 US9550771 Fauber, B; Gobbi, A Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=268437 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=268437&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122529854 377007297 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 509463 OC1CN(CCC1C(O)=O)c1nc(C(=O)c2c(Cl)cccc2C(F)(F)F)n2ccccc12 InChI=1S/C21H17ClF3N3O4/c22-13-5-3-4-12(21(23,24)25)16(13)17(30)19-26-18(14-6-1-2-8-28(14)19)27-9-7-11(20(31)32)15(29)10-27/h1-6,8,11,15,29H,7,9-10H2,(H,31,32) PSVGIMRVVSJLCX-UHFFFAOYSA-N 268438 1-[3-[2-chloro-6- (trifluoromethyl)benzoyl]imidazo [1,5-a]pyridin-1-yl]-3-hydroxy- piperidine-4-carboxylic acid::US9550771, Example 37 Nuclear receptor ROR-gamma [262-507] 72.0 25.00 C US Patent 10.7270/Q2417036 aid1795379 US9550771 Fauber, B; Gobbi, A Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=268438 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=268438&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122529842 377007298 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 509464 OC(=O)c1ccc(cc1O)-c1nc(C(=O)c2ccccc2C2CC2)n2ccccc12 InChI=1S/C24H18N2O4/c27-20-13-15(10-11-18(20)24(29)30)21-19-7-3-4-12-26(19)23(25-21)22(28)17-6-2-1-5-16(17)14-8-9-14/h1-7,10-14,27H,8-9H2,(H,29,30) GMNGQJANLXHCDO-UHFFFAOYSA-N 268439 4-[3-(2- cyclopropylbenzoyl)imidazo[1,5- a]pyridin-1-yl]-2-hydroxy- benzoic acid::US9550771, Example 38 Nuclear receptor ROR-gamma [262-507] 3.00 25.00 C US Patent 10.7270/Q2417036 aid1795379 US9550771 Fauber, B; Gobbi, A Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=268439 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=268439&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122529858 377007299 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 509465 FC(F)(F)c1cccc(Cl)c1C(=O)c1nc(-c2ccc3C(=O)NS(=O)(=O)c3c2)c2ccccn12 InChI=1S/C22H11ClF3N3O4S/c23-14-5-3-4-13(22(24,25)26)17(14)19(30)20-27-18(15-6-1-2-9-29(15)20)11-7-8-12-16(10-11)34(32,33)28-21(12)31/h1-10H,(H,28,31) YDIICRVLICJBFG-UHFFFAOYSA-N 268440 6-[3-[2-chloro-6- (trifluoromethyl)benzoyl]imidazo [1,5-a]pyridin-1-yl]-1,1-dioxo- 1,2-benzothiazol-3-one::US9550771, Example 39 Nuclear receptor ROR-gamma [262-507] 111 25.00 C US Patent 10.7270/Q2417036 aid1795379 US9550771 Fauber, B; Gobbi, A Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=268440 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=268440&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122529832 377007300 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 509466 OC(=O)c1ccc(cc1)-c1nc(C(=O)c2c(Cl)cccc2CC#N)n2ccccc12 InChI=1S/C23H14ClN3O3/c24-17-5-3-4-14(11-12-25)19(17)21(28)22-26-20(18-6-1-2-13-27(18)22)15-7-9-16(10-8-15)23(29)30/h1-10,13H,11H2,(H,29,30) WJQTXFFWPIQBBS-UHFFFAOYSA-N 268441 4-[3-[2-chloro-6- (cyanomethyl)benzoyl]imidazo [1,5-a]pyridin-1-yl]benzoic acid::US9550771, Example 40 Nuclear receptor ROR-gamma [262-507] 195 25.00 C US Patent 10.7270/Q2417036 aid1795379 US9550771 Fauber, B; Gobbi, A Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=268441 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=268441&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122529825 377007301 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 509467 O[C@@H]1CN(CC[C@H]1C(O)=O)c1nc(C(=O)c2c(Cl)cccc2C(F)(F)F)n2ccccc12 InChI=1S/C21H17ClF3N3O4/c22-13-5-3-4-12(21(23,24)25)16(13)17(30)19-26-18(14-6-1-2-8-28(14)19)27-9-7-11(20(31)32)15(29)10-27/h1-6,8,11,15,29H,7,9-10H2,(H,31,32)/t11-,15-/m1/s1 PSVGIMRVVSJLCX-IAQYHMDHSA-N 50106293 CHEMBL3596269::US9550771, Example 41 Nuclear receptor ROR-gamma [262-507] 97.0 25.00 C US Patent 10.7270/Q2417036 aid1795379 US9550771 Fauber, B; Gobbi, A Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50106293 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50106293&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122182699 319492797 CHEMBL3596269 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 509468 O[C@H]1CN(CC[C@@H]1C(O)=O)c1nc(C(=O)c2c(Cl)cccc2C(F)(F)F)n2ccccc12 InChI=1S/C21H17ClF3N3O4/c22-13-5-3-4-12(21(23,24)25)16(13)17(30)19-26-18(14-6-1-2-8-28(14)19)27-9-7-11(20(31)32)15(29)10-27/h1-6,8,11,15,29H,7,9-10H2,(H,31,32)/t11-,15-/m0/s1 PSVGIMRVVSJLCX-NHYWBVRUSA-N 50106292 CHEMBL3598155::US9550771, Example 92 Nuclear receptor ROR-gamma [262-507] 437 25.00 C US Patent 10.7270/Q2417036 aid1795379 US9550771 Fauber, B; Gobbi, A Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50106292 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50106292&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122184177 319492796 CHEMBL3598155 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 509469 CN(C)C(=O)c1ccc2c(nc(C(=O)c3c(Cl)cccc3C3CC3)n2c1)-c1ccc(cc1)C(O)=O InChI=1S/C27H22ClN3O4/c1-30(2)26(33)18-12-13-21-23(16-8-10-17(11-9-16)27(34)35)29-25(31(21)14-18)24(32)22-19(15-6-7-15)4-3-5-20(22)28/h3-5,8-15H,6-7H2,1-2H3,(H,34,35) WRYZXIWTOGSLTM-UHFFFAOYSA-N 268444 4-[3-(2-chloro-6-cyclopropyl- benzoyl)-6- (dimethylcarbamoyl)imidazo[1,5- a]pyridin-1-yl]benzoic acid::US9550771, Example 43 Nuclear receptor ROR-gamma [262-507] 6.00 25.00 C US Patent 10.7270/Q2417036 aid1795379 US9550771 Fauber, B; Gobbi, A Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=268444 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=268444&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122529857 377007304 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 509470 CN(C)C(=O)c1ccc2c(nc(C(=O)c3c(Cl)cccc3C3CC3)n2c1)C1=CCC(CC1)C(O)=O InChI=1S/C27H26ClN3O4/c1-30(2)26(33)18-12-13-21-23(16-8-10-17(11-9-16)27(34)35)29-25(31(21)14-18)24(32)22-19(15-6-7-15)4-3-5-20(22)28/h3-5,8,12-15,17H,6-7,9-11H2,1-2H3,(H,34,35) GUFQEQAIYSCPGG-UHFFFAOYSA-N 268445 4-[3-(2-chloro-6-cyclopropyl- benzoyl)-6- (dimethylcarbamoyl)imidazo[1,5- a]pyridin-1-yl]cyclohex-3-ene-1- carboxylic acid::US9550771, Example 44 Nuclear receptor ROR-gamma [262-507] 22.0 25.00 C US Patent 10.7270/Q2417036 aid1795379 US9550771 Fauber, B; Gobbi, A Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=268445 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=268445&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122529834 377007305 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 509471 OC1CN(CCC1C(O)=O)c1nc(C(=O)c2c(Cl)cccc2C2CC2)n2ccccc12 InChI=1S/C23H22ClN3O4/c24-16-5-3-4-14(13-7-8-13)19(16)20(29)22-25-21(17-6-1-2-10-27(17)22)26-11-9-15(23(30)31)18(28)12-26/h1-6,10,13,15,18,28H,7-9,11-12H2,(H,30,31) HEHJXQDTIPZDHS-UHFFFAOYSA-N 268446 1-[3-(2-chloro-6-cyclopropyl- benzoyl)imidazo[1,5-a]pyridin-1- yl]-3-hydroxy-piperidine-4- carboxylic acid::US9550771, Example 45 Nuclear receptor ROR-gamma [262-507] 139 25.00 C US Patent 10.7270/Q2417036 aid1795379 US9550771 Fauber, B; Gobbi, A Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=268446 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=268446&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122529861 377007306 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 509472 OCc1cc(ccc1-c1nc(C(=O)c2c(Cl)cccc2C2CC2)n2ccccc12)C(O)=O InChI=1S/C25H19ClN2O4/c26-19-5-3-4-17(14-7-8-14)21(19)23(30)24-27-22(20-6-1-2-11-28(20)24)18-10-9-15(25(31)32)12-16(18)13-29/h1-6,9-12,14,29H,7-8,13H2,(H,31,32) ICEVEDHMYRVPDH-UHFFFAOYSA-N 268447 4-[3-(2-chloro-6-cyclopropyl- benzoyl)imidazo[1,5-a]pyridin-1- yl]-3-(hydroxymethyl)benzoic acid::US9550771, Example 46 Nuclear receptor ROR-gamma [262-507] 109 25.00 C US Patent 10.7270/Q2417036 aid1795379 US9550771 Fauber, B; Gobbi, A Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=268447 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=268447&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122529852 377007307 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 509473 OC(=O)c1ccc(cc1O)-c1nc(C(=O)c2ccccc2N2CCOCC2)n2ccccc12 InChI=1S/C25H21N3O5/c29-21-15-16(8-9-18(21)25(31)32)22-20-7-3-4-10-28(20)24(26-22)23(30)17-5-1-2-6-19(17)27-11-13-33-14-12-27/h1-10,15,29H,11-14H2,(H,31,32) LPYGWLBKRVIXLS-UHFFFAOYSA-N 268448 2-hydroxy-4-[3-(2- morpholinobenzoyl)imidazo[1,5- a]pyridin-1-yl]benzoic acid::US9550771, Example 47 Nuclear receptor ROR-gamma [262-507] 50.0 25.00 C US Patent 10.7270/Q2417036 aid1795379 US9550771 Fauber, B; Gobbi, A Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=268448 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=268448&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122529860 377007308 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 509474 OC(=O)c1ccc(cc1)-c1nc(C(=O)c2c(Cl)cccc2C2CC2)n2cc(ccc12)C(=O)N1CCC1 InChI=1S/C28H22ClN3O4/c29-21-4-1-3-20(16-5-6-16)23(21)25(33)26-30-24(17-7-9-18(10-8-17)28(35)36)22-12-11-19(15-32(22)26)27(34)31-13-2-14-31/h1,3-4,7-12,15-16H,2,5-6,13-14H2,(H,35,36) KJKQXUULNHCCHZ-UHFFFAOYSA-N 268449 4-[6-(azetidine-1-carbonyl)-3-(2- chloro-6-cyclopropyl- benzoyl)imidazo[1,5-a]pyridin-1- yl]benzoic acid::US9550771, Example 48 Nuclear receptor ROR-gamma [262-507] 3.00 25.00 C US Patent 10.7270/Q2417036 aid1795379 US9550771 Fauber, B; Gobbi, A Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=268449 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=268449&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117964984 377007309 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 509475 O[C@@H]1CN(CC[C@H]1C(O)=O)c1nc(C(=O)c2c(Cl)cccc2C2CC2)n2ccccc12 InChI=1S/C23H22ClN3O4/c24-16-5-3-4-14(13-7-8-13)19(16)20(29)22-25-21(17-6-1-2-10-27(17)22)26-11-9-15(23(30)31)18(28)12-26/h1-6,10,13,15,18,28H,7-9,11-12H2,(H,30,31)/t15-,18-/m1/s1 HEHJXQDTIPZDHS-CRAIPNDOSA-N 268450 (3S,4R)-1-[3-(2-chloro-6- cyclopropyl- benzoyl)imidazo[1,5-a]pyridin-1- yl]-3-hydroxy-piperidine-4- carboxylic acid (RACEMATE)::US9550771, Example 49::US9550771, Example 51 Nuclear receptor ROR-gamma [262-507] 63.0 25.00 C US Patent 10.7270/Q2417036 aid1795379 US9550771 Fauber, B; Gobbi, A Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=268450 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=268450&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117964965 377007310 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 509476 O[C@H]1CN(CC[C@H]1C(O)=O)c1nc(C(=O)c2c(Cl)cccc2C2CC2)n2ccccc12 InChI=1S/C23H22ClN3O4/c24-16-5-3-4-14(13-7-8-13)19(16)20(29)22-25-21(17-6-1-2-10-27(17)22)26-11-9-15(23(30)31)18(28)12-26/h1-6,10,13,15,18,28H,7-9,11-12H2,(H,30,31)/t15-,18+/m1/s1 HEHJXQDTIPZDHS-QAPCUYQASA-N 268451 (3R,4R)-1-[3-(2-chloro-6- cyclopropyl- benzoyl)imidazo[1,5-a]pyridin-1- yl]-3-hydroxy-piperidine-4- carboxylic acid (RACEMATE)::US9550771, Example 50 Nuclear receptor ROR-gamma [262-507] 1500 25.00 C US Patent 10.7270/Q2417036 aid1795379 US9550771 Fauber, B; Gobbi, A Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=268451 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=268451&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117964964 377007311 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 509477 O[C@@H]1CN(CC[C@H]1C(O)=O)c1nc(C(=O)c2c(Cl)cccc2C2CC2)n2ccccc12 InChI=1S/C23H22ClN3O4/c24-16-5-3-4-14(13-7-8-13)19(16)20(29)22-25-21(17-6-1-2-10-27(17)22)26-11-9-15(23(30)31)18(28)12-26/h1-6,10,13,15,18,28H,7-9,11-12H2,(H,30,31)/t15-,18-/m1/s1 HEHJXQDTIPZDHS-CRAIPNDOSA-N 268450 (3S,4R)-1-[3-(2-chloro-6- cyclopropyl- benzoyl)imidazo[1,5-a]pyridin-1- yl]-3-hydroxy-piperidine-4- carboxylic acid (RACEMATE)::US9550771, Example 49::US9550771, Example 51 Nuclear receptor ROR-gamma [262-507] 29.0 25.00 C US Patent 10.7270/Q2417036 aid1795379 US9550771 Fauber, B; Gobbi, A Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=268450 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=268450&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117964965 377007310 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 509478 O[C@H]1CN(CC[C@@H]1C(O)=O)c1nc(C(=O)c2c(Cl)cccc2C2CC2)n2ccccc12 InChI=1S/C23H22ClN3O4/c24-16-5-3-4-14(13-7-8-13)19(16)20(29)22-25-21(17-6-1-2-10-27(17)22)26-11-9-15(23(30)31)18(28)12-26/h1-6,10,13,15,18,28H,7-9,11-12H2,(H,30,31)/t15-,18-/m0/s1 HEHJXQDTIPZDHS-YJBOKZPZSA-N 268453 (3R,4S)-1-[3-(2-chloro-6- cyclopropyl- benzoyl)imidazo[1,5-a]pyridin-1- yl]-3-hydroxy-piperidine-4- carboxylic acid::US9550771, Example 52 Nuclear receptor ROR-gamma [262-507] 369 25.00 C US Patent 10.7270/Q2417036 aid1795379 US9550771 Fauber, B; Gobbi, A Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=268453 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=268453&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117964969 377007312 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 509479 OC(=O)c1ccc(cc1O)-c1nc(C(=O)c2c(Cl)cccc2N2CCOCC2)n2ccccc12 InChI=1S/C25H20ClN3O5/c26-17-4-3-6-18(28-10-12-34-13-11-28)21(17)23(31)24-27-22(19-5-1-2-9-29(19)24)15-7-8-16(25(32)33)20(30)14-15/h1-9,14,30H,10-13H2,(H,32,33) NYYMGAIAXWUXHT-UHFFFAOYSA-N 268454 4-[3-(2-chloro-6-morpholino- benzoyl)imidazo[1,5-a]pyridin-1- yl]-2-hydroxy-benzoic acid::US9550771, Example 53 Nuclear receptor ROR-gamma [262-507] 3.00 25.00 C US Patent 10.7270/Q2417036 aid1795379 US9550771 Fauber, B; Gobbi, A Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=268454 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=268454&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117964985 377007313 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 509480 OC(=O)c1ccc(cc1O)-c1nc(C(=O)c2c(Cl)cccc2C2CC2)n2cccc(Cl)c12 InChI=1S/C24H16Cl2N2O4/c25-16-4-1-3-14(12-6-7-12)19(16)22(30)23-27-20(21-17(26)5-2-10-28(21)23)13-8-9-15(24(31)32)18(29)11-13/h1-5,8-12,29H,6-7H2,(H,31,32) QPNQFQHZVVTZFD-UHFFFAOYSA-N 268455 4-[8-chloro-3-(2-chloro-6- cyclopropyl- benzoyl)imidazo[1,5-a]pyridin-1- yl]-2-hydroxy-benzoic acid::US9550771, Example 54 Nuclear receptor ROR-gamma [262-507] 2.00 25.00 C US Patent 10.7270/Q2417036 aid1795379 US9550771 Fauber, B; Gobbi, A Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=268455 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=268455&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122529828 377007314 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 509481 OC1CN(CCC1C(O)=O)c1nc(C(=O)c2c(Cl)cccc2C2CC2)n2cc(ccc12)C(=O)N1CCC1 InChI=1S/C27H27ClN4O5/c28-19-4-1-3-17(15-5-6-15)22(19)23(34)25-29-24(31-12-9-18(27(36)37)21(33)14-31)20-8-7-16(13-32(20)25)26(35)30-10-2-11-30/h1,3-4,7-8,13,15,18,21,33H,2,5-6,9-12,14H2,(H,36,37) BJTIYNHKMMNZLW-UHFFFAOYSA-N 268456 1-[6-(azetidine-1-carbonyl)-3-(2- chloro-6-cyclopropyl- benzoyl)imidazo[1,5-a]pyridin-1- yl]-3-hydroxy-piperidine-4- carboxylic acid::US9550771, Example 55 Nuclear receptor ROR-gamma [262-507] 50.0 25.00 C US Patent 10.7270/Q2417036 aid1795379 US9550771 Fauber, B; Gobbi, A Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=268456 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=268456&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122529835 377007315 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 509482 CN(C)C(=O)c1ccc2c(nc(C(=O)c3c(Cl)cccc3C3CC3)n2c1)N1CC[C@H]([C@H](O)C1)C(O)=O InChI=1S/C26H27ClN4O5/c1-29(2)25(34)15-8-9-19-23(30-11-10-17(26(35)36)20(32)13-30)28-24(31(19)12-15)22(33)21-16(14-6-7-14)4-3-5-18(21)27/h3-5,8-9,12,14,17,20,32H,6-7,10-11,13H2,1-2H3,(H,35,36)/t17-,20-/m1/s1 BYKSVSOXQWTAGR-YLJYHZDGSA-N 268457 (3S,4R)-1-[3-(2-chloro-6- cyclopropyl-benzoyl)-6- (dimethylcarbamoyl)imidazo[1,5- a]pyridin-1-yl]-3-hydroxy- piperidine-4-carboxylic acid (RACEMATE)::US9550771, Example 56 Nuclear receptor ROR-gamma [262-507] 19.0 25.00 C US Patent 10.7270/Q2417036 aid1795379 US9550771 Fauber, B; Gobbi, A Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=268457 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=268457&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122529853 377007316 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 509483 CN(C)C(=O)c1ccc2c(nc(C(=O)c3c(Cl)cccc3C3CC3)n2c1)N1CC[C@H]([C@@H](O)C1)C(O)=O InChI=1S/C26H27ClN4O5/c1-29(2)25(34)15-8-9-19-23(30-11-10-17(26(35)36)20(32)13-30)28-24(31(19)12-15)22(33)21-16(14-6-7-14)4-3-5-18(21)27/h3-5,8-9,12,14,17,20,32H,6-7,10-11,13H2,1-2H3,(H,35,36)/t17-,20+/m1/s1 BYKSVSOXQWTAGR-XLIONFOSSA-N 268458 (3R,4R)-1-[3-(2-chloro-6- cyclopropyl-benzoyl)-6- (dimethylcarbamoyl)imidazo[1,5- a]pyridin-1-yl]-3-hydroxy- piperidine-4-carboxylic acid (RACEMATE)::US9550771, Example 57 Nuclear receptor ROR-gamma [262-507] 440 25.00 C US Patent 10.7270/Q2417036 aid1795379 US9550771 Fauber, B; Gobbi, A Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=268458 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=268458&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122529845 377007317 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 509484 COC1CN(C1)C(=O)c1ccc2c(nc(C(=O)c3c(Cl)cccc3C3CC3)n2c1)N1CCC(C(O)C1)C(O)=O InChI=1S/C28H29ClN4O6/c1-39-17-12-32(13-17)27(36)16-7-8-21-25(31-10-9-19(28(37)38)22(34)14-31)30-26(33(21)11-16)24(35)23-18(15-5-6-15)3-2-4-20(23)29/h2-4,7-8,11,15,17,19,22,34H,5-6,9-10,12-14H2,1H3,(H,37,38) NOFVRJLCNLQIDX-UHFFFAOYSA-N 268459 1-[3-(2-chloro-6-cyclopropyl- benzoyl)-6-(3-methoxyazetidine- 1-carbonyl)imidazo[1,5- a]pyridin-1-yl]-3-hydroxy- piperidine-4-carboxylic acid::US9550771, Example 58 Nuclear receptor ROR-gamma [262-507] 70.0 25.00 C US Patent 10.7270/Q2417036 aid1795379 US9550771 Fauber, B; Gobbi, A Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=268459 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=268459&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122529840 377007318 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 509485 OC(=O)C1CCC(CC1)c1nc(C(=O)c2c(Cl)cccc2C(F)(F)F)n2ccccc12 InChI=1S/C22H18ClF3N2O3/c23-15-5-3-4-14(22(24,25)26)17(15)19(29)20-27-18(16-6-1-2-11-28(16)20)12-7-9-13(10-8-12)21(30)31/h1-6,11-13H,7-10H2,(H,30,31) PPNHIYVYFFQQAM-UHFFFAOYSA-N 268460 4-[3-[2-chloro-6- (trifluoromethyl)benzoyl]imidazo [1,5-a]pyridin-1- yl]cyclohexanecarboxylic acid::US9550771, Example 59 Nuclear receptor ROR-gamma [262-507] 404 25.00 C US Patent 10.7270/Q2417036 aid1795379 US9550771 Fauber, B; Gobbi, A Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=268460 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=268460&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117964946 377007319 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 509486 O[C@@H]1CN(CC[C@H]1C(O)=O)c1nc(C(=O)c2c(Cl)cccc2C2CC2)n2cccc(Cl)c12 InChI=1S/C23H21Cl2N3O4/c24-15-4-1-3-13(12-6-7-12)18(15)20(30)22-26-21(19-16(25)5-2-9-28(19)22)27-10-8-14(23(31)32)17(29)11-27/h1-5,9,12,14,17,29H,6-8,10-11H2,(H,31,32)/t14-,17-/m1/s1 BSGHIZNLZVICMF-RHSMWYFYSA-N 268461 (3S,4R)-1-[8-chloro-3-(2-chloro- 6-cyclopropyl- benzoyl)imidazo[1,5-a]pyridin-1- yl]-3-hydroxy-piperidine-4- carboxylic acid (RACEMATE)::US9550771, Example 60 Nuclear receptor ROR-gamma [262-507] 13.0 25.00 C US Patent 10.7270/Q2417036 aid1795379 US9550771 Fauber, B; Gobbi, A Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=268461 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=268461&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117964953 377007320 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 509487 O[C@H]1CN(CC[C@H]1C(O)=O)c1nc(C(=O)c2c(Cl)cccc2C2CC2)n2cccc(Cl)c12 InChI=1S/C23H21Cl2N3O4/c24-15-4-1-3-13(12-6-7-12)18(15)20(30)22-26-21(19-16(25)5-2-9-28(19)22)27-10-8-14(23(31)32)17(29)11-27/h1-5,9,12,14,17,29H,6-8,10-11H2,(H,31,32)/t14-,17+/m1/s1 BSGHIZNLZVICMF-PBHICJAKSA-N 268462 (3R,4R)-1-[8-chloro-3-(2-chloro- 6-cyclopropyl- benzoyl)imidazo[1,5-a]pyridin-1- yl]-3-hydroxy-piperidine-4- carboxylic acid (RACEMATE)::US9550771, Example 61 Nuclear receptor ROR-gamma [262-507] 194 25.00 C US Patent 10.7270/Q2417036 aid1795379 US9550771 Fauber, B; Gobbi, A Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=268462 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=268462&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122529851 377007321 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 509488 OC(=O)c1ccc(cc1O)-c1nc(C(=O)c2ccccc2C(F)(F)F)n2CCCCc12 InChI=1S/C22H17F3N2O4/c23-22(24,25)15-6-2-1-5-13(15)19(29)20-26-18(16-7-3-4-10-27(16)20)12-8-9-14(21(30)31)17(28)11-12/h1-2,5-6,8-9,11,28H,3-4,7,10H2,(H,30,31) USEUCXXHGOMPNX-UHFFFAOYSA-N 268463 2-hydroxy-4-[3-[2- (trifluoromethyl)benzoyl]-5,6,7,8- tetrahydroimidazo[1,5-a]pyridin- 1-yl]benzoic acid::US9550771, Example 62 Nuclear receptor ROR-gamma [262-507] 49.0 25.00 C US Patent 10.7270/Q2417036 aid1795379 US9550771 Fauber, B; Gobbi, A Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=268463 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=268463&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122529836 377007322 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 509489 OC(=O)c1ccc(-c2nc(C(=O)c3ccccc3C(F)(F)F)n3CCCCc23)c(F)c1 InChI=1S/C22H16F4N2O3/c23-16-11-12(21(30)31)8-9-14(16)18-17-7-3-4-10-28(17)20(27-18)19(29)13-5-1-2-6-15(13)22(24,25)26/h1-2,5-6,8-9,11H,3-4,7,10H2,(H,30,31) PXZVETSQGNIYAQ-UHFFFAOYSA-N 50106294 CHEMBL3596271::US9550771, Example 63 Nuclear receptor ROR-gamma [262-507] 842 25.00 C US Patent 10.7270/Q2417036 aid1795379 US9550771 Fauber, B; Gobbi, A Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50106294 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50106294&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122182700 319492798 CHEMBL3596271 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 509490 OC(=O)c1ccc(-c2nc(C(=O)c3c(F)cccc3Cl)n3CCCCc23)c(F)c1 InChI=1S/C21H15ClF2N2O3/c22-13-4-3-5-14(23)17(13)19(27)20-25-18(16-6-1-2-9-26(16)20)12-8-7-11(21(28)29)10-15(12)24/h3-5,7-8,10H,1-2,6,9H2,(H,28,29) LYQOYBQJYMWTBG-UHFFFAOYSA-N 50106295 CHEMBL3596272::US9550771, Example 64 Nuclear receptor ROR-gamma [262-507] 191 25.00 C US Patent 10.7270/Q2417036 aid1795379 US9550771 Fauber, B; Gobbi, A Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50106295 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50106295&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122182701 319492799 CHEMBL3596272 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 509491 OC(=O)c1ccc(-c2nc(C(=O)c3c(F)cccc3F)n3CCCCc23)c(F)c1 InChI=1S/C21H15F3N2O3/c22-13-4-3-5-14(23)17(13)19(27)20-25-18(16-6-1-2-9-26(16)20)12-8-7-11(21(28)29)10-15(12)24/h3-5,7-8,10H,1-2,6,9H2,(H,28,29) JMFCFXVFIGMVGB-UHFFFAOYSA-N 268466 4-[3-(2,6-difluorobenzoyl)- 5,6,7,8-tetrahydroimidazo[1,5- a]pyridin-1-yl]-3-fluoro-benzoic acid::US9550771, Example 65 Nuclear receptor ROR-gamma [262-507] 420 25.00 C US Patent 10.7270/Q2417036 aid1795379 US9550771 Fauber, B; Gobbi, A Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=268466 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=268466&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122529856 377007325 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 509492 ONC(=O)c1ccc(cc1)-c1nc(C(=O)c2c(Cl)cccc2C(F)(F)F)n2CCCCc12 InChI=1S/C22H17ClF3N3O3/c23-15-5-3-4-14(22(24,25)26)17(15)19(30)20-27-18(16-6-1-2-11-29(16)20)12-7-9-13(10-8-12)21(31)28-32/h3-5,7-10,32H,1-2,6,11H2,(H,28,31) GAYCVSBIRBAJLB-UHFFFAOYSA-N 268467 4-[3-[2-chloro-6- (trifluoromethyl)benzoyl]-5,6,7,8- tetrahydroimidazo[1,5-a]pyridin- 1-yl]benzenecarbohydroxamic acid::US9550771, Example 66 Nuclear receptor ROR-gamma [262-507] 3100 25.00 C US Patent 10.7270/Q2417036 aid1795379 US9550771 Fauber, B; Gobbi, A Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=268467 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=268467&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117964955 377007326 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 509493 OC(=O)c1ccc(cc1)-c1nc(C(=O)c2c(Cl)cccc2Cl)n2CCCCc12 InChI=1S/C21H16Cl2N2O3/c22-14-4-3-5-15(23)17(14)19(26)20-24-18(16-6-1-2-11-25(16)20)12-7-9-13(10-8-12)21(27)28/h3-5,7-10H,1-2,6,11H2,(H,27,28) YEGDBFCQBMWARY-UHFFFAOYSA-N 268468 4-[3-(2,6-dichlorobenzoyl)- 5,6,7,8-tetrahydroimidazo[1,5- a]pyridin-1-yl]benzoic acid::US9550771, Example 67 Nuclear receptor ROR-gamma [262-507] 195 25.00 C US Patent 10.7270/Q2417036 aid1795379 US9550771 Fauber, B; Gobbi, A Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=268468 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=268468&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117964948 377007327 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 509494 OC(=O)c1ccc(cc1O)-c1nc(C(=O)c2c(Cl)cccc2Cl)n2CCCCc12 InChI=1S/C21H16Cl2N2O4/c22-13-4-3-5-14(23)17(13)19(27)20-24-18(15-6-1-2-9-25(15)20)11-7-8-12(21(28)29)16(26)10-11/h3-5,7-8,10,26H,1-2,6,9H2,(H,28,29) ISFUJDIYAHBBSS-UHFFFAOYSA-N 268469 4-[3-(2,6-dichlorobenzoyl)- 5,6,7,8-tetrahydroimidazo[1,5- a]pyridin-1-yl]-2-hydroxy- benzoic acid::US9550771, Example 68 Nuclear receptor ROR-gamma [262-507] 8.00 25.00 C US Patent 10.7270/Q2417036 aid1795379 US9550771 Fauber, B; Gobbi, A Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=268469 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=268469&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117964949 377007328 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 509495 OC(=O)c1ccc(-c2nc(C(=O)c3c(Cl)cccc3Cl)n3CCCCc23)c(F)c1 InChI=1S/C21H15Cl2FN2O3/c22-13-4-3-5-14(23)17(13)19(27)20-25-18(16-6-1-2-9-26(16)20)12-8-7-11(21(28)29)10-15(12)24/h3-5,7-8,10H,1-2,6,9H2,(H,28,29) ZENLCDFVQUEFSK-UHFFFAOYSA-N 50106296 CHEMBL3596273::US9550771, Example 69 Nuclear receptor ROR-gamma [262-507] 77.0 25.00 C US Patent 10.7270/Q2417036 aid1795379 US9550771 Fauber, B; Gobbi, A Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50106296 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50106296&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117964950 319492800 CHEMBL3596273 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 509496 FC(F)(F)c1cccc(Cl)c1C(=O)c1nc(c2CCCCn12)-c1ccc(NS(=O)(=O)C(F)(F)F)cc1 InChI=1S/C22H16ClF6N3O3S/c23-15-5-3-4-14(21(24,25)26)17(15)19(33)20-30-18(16-6-1-2-11-32(16)20)12-7-9-13(10-8-12)31-36(34,35)22(27,28)29/h3-5,7-10,31H,1-2,6,11H2 XGNZUMNDBUXCBN-UHFFFAOYSA-N 268471 N-[4-[3-[2-chloro-6- (trifluoromethyl)benzoyl]-5,6,7,8- tetrahydroimidazo[1,5-a]pyridin- 1-yl]phenyl]-1,1,1-trifluoro- methanesulfonamide::US9550771, Example 70 Nuclear receptor ROR-gamma [262-507] 1800 25.00 C US Patent 10.7270/Q2417036 aid1795379 US9550771 Fauber, B; Gobbi, A Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=268471 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=268471&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122529841 377007330 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 509497 OC(=O)c1ccc(-c2nc(C(=O)c3c(cccc3C(F)(F)F)C#N)n3CCCCc23)c(F)c1 InChI=1S/C23H15F4N3O3/c24-16-10-12(22(32)33)7-8-14(16)19-17-6-1-2-9-30(17)21(29-19)20(31)18-13(11-28)4-3-5-15(18)23(25,26)27/h3-5,7-8,10H,1-2,6,9H2,(H,32,33) GCPABWQSYTVJOD-UHFFFAOYSA-N 50106299 CHEMBL3596277::US9550771, Example 71 Nuclear receptor ROR-gamma [262-507] 215 25.00 C US Patent 10.7270/Q2417036 aid1795379 US9550771 Fauber, B; Gobbi, A Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50106299 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50106299&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117964951 319492803 CHEMBL3596277 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 509498 COc1cccc(Cl)c1C(=O)c1nc(c2CCCCn12)-c1ccc(cc1F)C(O)=O InChI=1S/C22H18ClFN2O4/c1-30-17-7-4-5-14(23)18(17)20(27)21-25-19(16-6-2-3-10-26(16)21)13-9-8-12(22(28)29)11-15(13)24/h4-5,7-9,11H,2-3,6,10H2,1H3,(H,28,29) XYJWRFFZVGIEEG-UHFFFAOYSA-N 50106298 CHEMBL3596275::US9550771, Example 72 Nuclear receptor ROR-gamma [262-507] 236 25.00 C US Patent 10.7270/Q2417036 aid1795379 US9550771 Fauber, B; Gobbi, A Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50106298 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50106298&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122182703 319492802 CHEMBL3596275 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 509499 OC(=O)c1ccc(cc1O)-c1nc(C(=O)c2c(Br)cccc2C(F)(F)F)n2CCCCc12 InChI=1S/C22H16BrF3N2O4/c23-14-5-3-4-13(22(24,25)26)17(14)19(30)20-27-18(15-6-1-2-9-28(15)20)11-7-8-12(21(31)32)16(29)10-11/h3-5,7-8,10,29H,1-2,6,9H2,(H,31,32) OQQRDXHFPVGCSX-UHFFFAOYSA-N 268474 4-[3-[2-bromo-6- (trifluoromethyl)benzoyl]-5,6,7,8- tetrahydroimidazo[1,5-a]pyridin- 1-yl]-2-hydroxy-benzoic acid::US9550771, Example 73 Nuclear receptor ROR-gamma [262-507] 6.00 25.00 C US Patent 10.7270/Q2417036 aid1795379 US9550771 Fauber, B; Gobbi, A Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=268474 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=268474&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117964961 377007333 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 509500 OC(=O)c1ccc(cc1O)-c1nc(C(=O)c2c(Cl)cccc2Br)n2CCCCc12 InChI=1S/C21H16BrClN2O4/c22-13-4-3-5-14(23)17(13)19(27)20-24-18(15-6-1-2-9-25(15)20)11-7-8-12(21(28)29)16(26)10-11/h3-5,7-8,10,26H,1-2,6,9H2,(H,28,29) HAAAJVKGCLZQSI-UHFFFAOYSA-N 268475 4-[3-(2-bromo-6-chloro-benzoyl)- 5,6,7,8-tetrahydroimidazo[1,5- a]pyridin-1-yl]-2-hydroxy- benzoic acid::US9550771, Example 74 Nuclear receptor ROR-gamma [262-507] 7.00 25.00 C US Patent 10.7270/Q2417036 aid1795379 US9550771 Fauber, B; Gobbi, A Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=268475 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=268475&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122529839 377007334 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 509501 Nc1cc(ccc1C(O)=O)-c1nc(C(=O)c2c(Cl)cccc2C(F)(F)F)n2CCCCc12 InChI=1S/C22H17ClF3N3O3/c23-14-5-3-4-13(22(24,25)26)17(14)19(30)20-28-18(16-6-1-2-9-29(16)20)11-7-8-12(21(31)32)15(27)10-11/h3-5,7-8,10H,1-2,6,9,27H2,(H,31,32) ZNAUWMTYDBOXBB-UHFFFAOYSA-N 268476 2-amino-4-[3-[2-chloro-6- (trifluoromethyl)benzoyl]-5,6,7,8- tetrahydroimidazo[1,5-a]pyridin- 1-yl]benzoic acid::US9550771, Example 75 Nuclear receptor ROR-gamma [262-507] 1600 25.00 C US Patent 10.7270/Q2417036 aid1795379 US9550771 Fauber, B; Gobbi, A Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=268476 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=268476&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117964981 377007335 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 509502 Oc1cc(=O)oc2cc(ccc12)-c1nc(C(=O)c2c(Cl)cccc2C(F)(F)F)n2CCCCc12 InChI=1S/C24H16ClF3N2O4/c25-15-5-3-4-14(24(26,27)28)20(15)22(33)23-29-21(16-6-1-2-9-30(16)23)12-7-8-13-17(31)11-19(32)34-18(13)10-12/h3-5,7-8,10-11,31H,1-2,6,9H2 CWAMGKFHFVUIDI-UHFFFAOYSA-N 268477 7-[3-[2-chloro-6- (trifluoromethyl)benzoyl]-5,6,7,8- tetrahydroimidazo[1,5-a]pyridin- 1-yl]-4-hydroxy-chromen-2-one::US9550771, Example 76 Nuclear receptor ROR-gamma [262-507] 1600 25.00 C US Patent 10.7270/Q2417036 aid1795379 US9550771 Fauber, B; Gobbi, A Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=268477 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=268477&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117964983 377007336 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 509503 Cc1cccc(c1C(=O)c1nc(c2CCCCn12)-c1ccc(C(O)=O)c(O)c1)C(F)(F)F InChI=1S/C23H19F3N2O4/c1-12-5-4-6-15(23(24,25)26)18(12)20(30)21-27-19(16-7-2-3-10-28(16)21)13-8-9-14(22(31)32)17(29)11-13/h4-6,8-9,11,29H,2-3,7,10H2,1H3,(H,31,32) CGGUFQYAXIPHKB-UHFFFAOYSA-N 268478 2-hydroxy-4-[3-[2-methyl-6- (trifluoromethyl)benzoyl]-5,6,7,8- tetrahydroimidazo[1,5-a]pyridin- 1-yl]benzoic acid::US9550771, Example 77 Nuclear receptor ROR-gamma [262-507] 14.0 25.00 C US Patent 10.7270/Q2417036 aid1795379 US9550771 Fauber, B; Gobbi, A Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=268478 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=268478&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117964968 377007337 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 509504 OC(=O)c1c(O)cc(cc1F)-c1nc(C(=O)c2c(Cl)cccc2C(F)(F)F)n2CCCCc12 InChI=1S/C22H15ClF4N2O4/c23-12-5-3-4-11(22(25,26)27)16(12)19(31)20-28-18(14-6-1-2-7-29(14)20)10-8-13(24)17(21(32)33)15(30)9-10/h3-5,8-9,30H,1-2,6-7H2,(H,32,33) LPTKLVMNFZHOSL-UHFFFAOYSA-N 268479 4-[3-[2-chloro-6- (trifluoromethyl)benzoyl]-5,6,7,8- tetrahydroimidazo[1,5-a]pyridin- 1-yl]-2-fluoro-6-hydroxy-benzoic acid::US9550771, Example 78 Nuclear receptor ROR-gamma [262-507] 4.00 25.00 C US Patent 10.7270/Q2417036 aid1795379 US9550771 Fauber, B; Gobbi, A Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=268479 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=268479&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117964958 377007338 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 509505 COc1cccc(c1C(=O)c1nc(c2CCCCn12)-c1ccc(cc1F)C(O)=O)C(F)(F)F InChI=1S/C23H18F4N2O4/c1-33-17-7-4-5-14(23(25,26)27)18(17)20(30)21-28-19(16-6-2-3-10-29(16)21)13-9-8-12(22(31)32)11-15(13)24/h4-5,7-9,11H,2-3,6,10H2,1H3,(H,31,32) QMZQFEKUHKOUPA-UHFFFAOYSA-N 50106300 CHEMBL3596278::US9550771, Example 79 Nuclear receptor ROR-gamma [262-507] 672 25.00 C US Patent 10.7270/Q2417036 aid1795379 US9550771 Fauber, B; Gobbi, A Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50106300 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50106300&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117964963 319492804 CHEMBL3596278 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 509506 OC(=O)c1cc(F)c(cc1O)-c1nc(C(=O)c2c(Cl)cccc2C(F)(F)F)n2CCCCc12 InChI=1S/C22H15ClF4N2O4/c23-13-5-3-4-12(22(25,26)27)17(13)19(31)20-28-18(15-6-1-2-7-29(15)20)10-9-16(30)11(21(32)33)8-14(10)24/h3-5,8-9,30H,1-2,6-7H2,(H,32,33) JXNQHZQPIZBXKK-UHFFFAOYSA-N 268481 4-[3-[2-chloro-6- (trifluoromethyl)benzoyl]-5,6,7,8- tetrahydroimidazo[1,5-a]pyridin- 1-yl]-5-fluoro-2-hydroxy-benzoic acid::US9550771, Example 80 Nuclear receptor ROR-gamma [262-507] 6.00 25.00 C US Patent 10.7270/Q2417036 aid1795379 US9550771 Fauber, B; Gobbi, A Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=268481 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=268481&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117964944 377007340 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 509507 Cc1cc(C(O)=O)c(O)cc1-c1nc(C(=O)c2c(Cl)cccc2C(F)(F)F)n2CCCCc12 InChI=1S/C23H18ClF3N2O4/c1-11-9-13(22(32)33)17(30)10-12(11)19-16-7-2-3-8-29(16)21(28-19)20(31)18-14(23(25,26)27)5-4-6-15(18)24/h4-6,9-10,30H,2-3,7-8H2,1H3,(H,32,33) WQBSFWMTHQQHMQ-UHFFFAOYSA-N 268482 4-[3-[2-chloro-6- (trifluoromethyl)benzoyl]-5,6,7,8- tetrahydroimidazo[1,5-a]pyridin- 1-yl]-2-hydroxy-5-methyl- benzoic acid::US9550771, Example 81 Nuclear receptor ROR-gamma [262-507] 12.0 25.00 C US Patent 10.7270/Q2417036 aid1795379 US9550771 Fauber, B; Gobbi, A Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=268482 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=268482&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117964943 377007341 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 509508 OC(=O)c1ccc(-c2nc(C(=O)c3c(Cl)cccc3C(F)(F)F)n3CCCCc23)c(F)c1O InChI=1S/C22H15ClF4N2O4/c23-13-5-3-4-12(22(25,26)27)15(13)19(31)20-28-17(14-6-1-2-9-29(14)20)10-7-8-11(21(32)33)18(30)16(10)24/h3-5,7-8,30H,1-2,6,9H2,(H,32,33) LBTHOKGYILFTBT-UHFFFAOYSA-N 268483 4-[3-[2-chloro-6- (trifluoromethyl)benzoyl]-5,6,7,8- tetrahydroimidazo[1,5-a]pyridin- 1-yl]-3-fluoro-2-hydroxy-benzoic acid::US9550771, Example 82 Nuclear receptor ROR-gamma [262-507] 4.00 25.00 C US Patent 10.7270/Q2417036 aid1795379 US9550771 Fauber, B; Gobbi, A Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=268483 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=268483&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117964929 377007342 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 509509 OC(=O)C1CCC(=CC1)c1nc(C(=O)c2c(Cl)cccc2C(F)(F)F)n2CCCCc12 InChI=1S/C22H20ClF3N2O3/c23-15-5-3-4-14(22(24,25)26)17(15)19(29)20-27-18(16-6-1-2-11-28(16)20)12-7-9-13(10-8-12)21(30)31/h3-5,7,13H,1-2,6,8-11H2,(H,30,31) YFOJKVZIEISBLZ-UHFFFAOYSA-N 268484 4-[3-[2-chloro-6- (trifluoromethyl)benzoyl]-5,6,7,8- tetrahydroimidazo[1,5-a]pyridin- 1-yl]cyclohex-3-ene-1-carboxylic acid::US9550771, Example 83 Nuclear receptor ROR-gamma [262-507] 833 25.00 C US Patent 10.7270/Q2417036 aid1795379 US9550771 Fauber, B; Gobbi, A Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=268484 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=268484&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117964933 377007343 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 509510 CNc1cc(ccc1C(O)=O)-c1nc(C(=O)c2c(Cl)cccc2C(F)(F)F)n2CCCCc12 InChI=1S/C23H19ClF3N3O3/c1-28-16-11-12(8-9-13(16)22(32)33)19-17-7-2-3-10-30(17)21(29-19)20(31)18-14(23(25,26)27)5-4-6-15(18)24/h4-6,8-9,11,28H,2-3,7,10H2,1H3,(H,32,33) YJDVLPPSXHMJKT-UHFFFAOYSA-N 268485 4-[3-[2-chloro-6- (trifluoromethyl)benzoyl]-5,6,7,8- tetrahydroimidazo[1,5-a]pyridin- 1-yl]-2-(methylamino)benzoic acid::US9550771, Example 84 Nuclear receptor ROR-gamma [262-507] 5300 25.00 C US Patent 10.7270/Q2417036 aid1795379 US9550771 Fauber, B; Gobbi, A Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=268485 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=268485&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122529862 377007344 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 509511 COc1cc(Cl)c(C(=O)c2nc(c3CCCCn23)-c2ccc(cc2)C(O)=O)c(Cl)c1 InChI=1S/C22H18Cl2N2O4/c1-30-14-10-15(23)18(16(24)11-14)20(27)21-25-19(17-4-2-3-9-26(17)21)12-5-7-13(8-6-12)22(28)29/h5-8,10-11H,2-4,9H2,1H3,(H,28,29) PONJXPVZFSRVPR-UHFFFAOYSA-N 268486 4-[3-(2,6-dichloro-4-methoxy- benzoyl)-5,6,7,8- tetrahydroimidazo[1,5-a]pyridin- 1-yl]benzoic acid::US9550771, Example 85 Nuclear receptor ROR-gamma [262-507] 2000 25.00 C US Patent 10.7270/Q2417036 aid1795379 US9550771 Fauber, B; Gobbi, A Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=268486 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=268486&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122529837 377007345 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 509512 COc1cc(Cl)cc(Cl)c1C(=O)c1nc(c2CCCCn12)-c1ccc(cc1)C(O)=O InChI=1S/C22H18Cl2N2O4/c1-30-17-11-14(23)10-15(24)18(17)20(27)21-25-19(16-4-2-3-9-26(16)21)12-5-7-13(8-6-12)22(28)29/h5-8,10-11H,2-4,9H2,1H3,(H,28,29) LHACDSURZUNJQP-UHFFFAOYSA-N 268487 4-[3-(2,4-dichloro-6-methoxy- benzoyl)-5,6,7,8- tetrahydroimidazo[1,5-a]pyridin- 1-yl]benzoic acid::US9550771, Example 86 Nuclear receptor ROR-gamma [262-507] 3000 25.00 C US Patent 10.7270/Q2417036 aid1795379 US9550771 Fauber, B; Gobbi, A Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=268487 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=268487&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117964924 377007346 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 509513 FC(F)(F)c1cccc(Cl)c1C(=O)c1nc(c2CCCCn12)-c1ccc2C(=O)NS(=O)(=O)c2c1 InChI=1S/C22H15ClF3N3O4S/c23-14-5-3-4-13(22(24,25)26)17(14)19(30)20-27-18(15-6-1-2-9-29(15)20)11-7-8-12-16(10-11)34(32,33)28-21(12)31/h3-5,7-8,10H,1-2,6,9H2,(H,28,31) BFDFLAGRTATNEE-UHFFFAOYSA-N 268488 6-[3-[2-chloro-6- (trifluoromethyl)benzoyl]-5,6,7,8- tetrahydroimidazo[1,5-a]pyridin- 1-yl]-1,1-dioxo-1,2-benzothiazol- 3-one::US9550771, Example 87 Nuclear receptor ROR-gamma [262-507] 691 25.00 C US Patent 10.7270/Q2417036 aid1795379 US9550771 Fauber, B; Gobbi, A Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=268488 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=268488&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117964972 377007347 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 509514 OC(=O)c1ccc(-c2nc(C(=O)c3c(Cl)cccc3C#N)n3CCCCc23)c(F)c1 InChI=1S/C22H15ClFN3O3/c23-15-5-3-4-13(11-25)18(15)20(28)21-26-19(17-6-1-2-9-27(17)21)14-8-7-12(22(29)30)10-16(14)24/h3-5,7-8,10H,1-2,6,9H2,(H,29,30) JBTNQIRSIMLEKM-UHFFFAOYSA-N 50106297 CHEMBL3596274::US9550771, Example 88 Nuclear receptor ROR-gamma [262-507] 250 25.00 C US Patent 10.7270/Q2417036 aid1795379 US9550771 Fauber, B; Gobbi, A Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50106297 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50106297&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122182702 319492801 CHEMBL3596274 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 509515 OC(=O)c1ccc(-c2nc(C(=O)c3c(Cl)cccc3C3CC3)n3CCCCc23)c(F)c1 InChI=1S/C24H20ClFN2O3/c25-17-5-3-4-15(13-7-8-13)20(17)22(29)23-27-21(19-6-1-2-11-28(19)23)16-10-9-14(24(30)31)12-18(16)26/h3-5,9-10,12-13H,1-2,6-8,11H2,(H,30,31) PCWVUKNALKMATE-UHFFFAOYSA-N 50106290 CHEMBL3596276::US9550771, Example 89 Nuclear receptor ROR-gamma [262-507] 27.0 25.00 C US Patent 10.7270/Q2417036 aid1795379 US9550771 Fauber, B; Gobbi, A Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50106290 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50106290&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117964973 319492794 CHEMBL3596276 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 509516 Cc1cc(C(O)=O)c(O)cc1-c1nc(C(=O)c2c(Cl)cccc2C2CC2)n2CCCCc12 InChI=1S/C25H23ClN2O4/c1-13-11-17(25(31)32)20(29)12-16(13)22-19-7-2-3-10-28(19)24(27-22)23(30)21-15(14-8-9-14)5-4-6-18(21)26/h4-6,11-12,14,29H,2-3,7-10H2,1H3,(H,31,32) UVNSKDMDTJPPIC-UHFFFAOYSA-N 268491 4-[3-(2-chloro-6-cyclopropyl- benzoyl)-5,6,7,8- tetrahydroimidazo[1,5-a]pyridin- 1-yl]-2-hydroxy-5-methyl- benzoic acid; formic acid::US9550771, Example 90 Nuclear receptor ROR-gamma [262-507] 9.00 25.00 C US Patent 10.7270/Q2417036 aid1795379 US9550771 Fauber, B; Gobbi, A Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=268491 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=268491&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122529846 377007350 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 509517 OC(=O)c1ccc(cc1O)-c1nc(C(=O)c2c(Cl)cccc2C2CC2)n2cccnc12 InChI=1S/C23H16ClN3O4/c24-16-4-1-3-14(12-5-6-12)18(16)20(29)22-26-19(21-25-9-2-10-27(21)22)13-7-8-15(23(30)31)17(28)11-13/h1-4,7-12,28H,5-6H2,(H,30,31) GIYKJPISDNWSJD-UHFFFAOYSA-N 50106285 CHEMBL3596279::US9550771, Example 91 Nuclear receptor ROR-gamma [262-507] 2.00 25.00 C US Patent 10.7270/Q2417036 aid1795379 US9550771 Fauber, B; Gobbi, A Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50106285 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50106285&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117964975 319492789 CHEMBL3596279 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 509518 O[C@H]1CN(CC[C@@H]1C(O)=O)c1nc(C(=O)c2c(Cl)cccc2C(F)(F)F)n2ccccc12 InChI=1S/C21H17ClF3N3O4/c22-13-5-3-4-12(21(23,24)25)16(13)17(30)19-26-18(14-6-1-2-8-28(14)19)27-9-7-11(20(31)32)15(29)10-27/h1-6,8,11,15,29H,7,9-10H2,(H,31,32)/t11-,15-/m0/s1 PSVGIMRVVSJLCX-NHYWBVRUSA-N 50106292 CHEMBL3598155::US9550771, Example 92 Nuclear receptor ROR-gamma [262-507] 305 25.00 C US Patent 10.7270/Q2417036 aid1795379 US9550771 Fauber, B; Gobbi, A Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50106292 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50106292&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122184177 319492796 CHEMBL3598155 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 509519 OC(=O)C1CCC(CC1)c1nc(C(=O)c2c(Cl)cccc2C(F)(F)F)n2ccccc12 InChI=1S/C22H18ClF3N2O3/c23-15-5-3-4-14(22(24,25)26)17(15)19(29)20-27-18(16-6-1-2-11-28(16)20)12-7-9-13(10-8-12)21(30)31/h1-6,11-13H,7-10H2,(H,30,31) PPNHIYVYFFQQAM-UHFFFAOYSA-N 268494 4-[3-[2-chloro-6- (trifluoromethyl)benzoyl]imidazo [1,5-a]pyridin-1- yl]cyclohexanecarboxylic acid::US9550771, Example 93 Nuclear receptor ROR-gamma [262-507] 4300 25.00 C US Patent 10.7270/Q2417036 aid1795379 US9550771 Fauber, B; Gobbi, A Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=268494 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=268494&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117964946 377007353 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 640603 Fc1ccc(cc1)S(=O)(=O)C1(CCOCC1)c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F InChI=1S/C27H21F9O4S/c28-19-8-10-20(11-9-19)41(37,38)24(12-14-39-15-13-24)17-4-6-18(7-5-17)25(26(31,32)33,27(34,35)36)40-16-21-22(29)2-1-3-23(21)30/h1-11H,12-16H2 UJYPJXGRUNXLOK-UHFFFAOYSA-N 326335 US9637455, 1 Nuclear receptor ROR-gamma [262-507] 170 US Patent 10.7270/Q21R6SKX aid1796769 US9637455 Duan, J; Dhar, TG; Jiang, B; Karmakar, A; Gupta, AK; Lu, Z Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326335 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326335&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118219068 384581291 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 640604 Fc1ccc(cc1)S(=O)(=O)C(=C)c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F InChI=1S/C24H15F9O3S/c1-14(37(34,35)18-11-9-17(25)10-12-18)15-5-7-16(8-6-15)22(23(28,29)30,24(31,32)33)36-13-19-20(26)3-2-4-21(19)27/h2-12H,1,13H2 XUJVCVLNDXVLPH-UHFFFAOYSA-N 325785 (3-(4-(2-((2,6-difluorobenzyl)oxy)-1,1,1,3,3,3-hexafluoropropan-2-yl)phenyl)-3-((4-fluorophenyl)sulfonyl)piperidin-1-yl)(4-hydroxy-4-(trifluoromethyl)piperidin-1-yl)methanone::US9637455, 2 Nuclear receptor ROR-gamma [262-507] 2630 US Patent 10.7270/Q21R6SKX aid1796769 US9637455 Duan, J; Dhar, TG; Jiang, B; Karmakar, A; Gupta, AK; Lu, Z Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=325785 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=325785&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118208073 384580750 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 640605 CC(C)(C)OC(=O)N1CCC(CC1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C32H30F9NO5S/c1-28(2,3)47-27(43)42-17-15-29(16-18-42,48(44,45)23-13-11-22(33)12-14-23)20-7-9-21(10-8-20)30(31(36,37)38,32(39,40)41)46-19-24-25(34)5-4-6-26(24)35/h4-14H,15-19H2,1-3H3 ATWDSVMKVQYHBH-UHFFFAOYSA-N 325786 1-(4-(4-(4-(2-((2,6-difluorobenzyl)oxy)-1,1,1,3,3,3-hexafluoropropan-2-yl)phenyl)-4-((4-fluorophenyl)sulfonyl)piperidine-1-carbonyl)piperazin-1-yl)ethanone::US9637455, 3 Nuclear receptor ROR-gamma [262-507] 219 US Patent 10.7270/Q21R6SKX aid1796769 US9637455 Duan, J; Dhar, TG; Jiang, B; Karmakar, A; Gupta, AK; Lu, Z Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=325786 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=325786&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118209041 384580751 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 640606 Fc1ccc(cc1)S(=O)(=O)C1(CCN(CC1)C(=O)CC1CCOCC1)c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F InChI=1S/C34H32F9NO5S/c35-25-8-10-26(11-9-25)50(46,47)31(14-16-44(17-15-31)30(45)20-22-12-18-48-19-13-22)23-4-6-24(7-5-23)32(33(38,39)40,34(41,42)43)49-21-27-28(36)2-1-3-29(27)37/h1-11,22H,12-21H2 IXXZPORRDATIIK-UHFFFAOYSA-N 325787 1-(4-(4-(2-((2,6-difluorobenzyl)oxy)-1,1,1,3,3,3-hexafluoropropan-2-yl)phenyl)-4-((4-fluorophenyl)sulfonyl)piperidin-1-yl)-2-(tetrahydro-2H-pyran-4-yl)ethanone::US9637455, 4 Nuclear receptor ROR-gamma [262-507] 57.0 US Patent 10.7270/Q21R6SKX aid1796769 US9637455 Duan, J; Dhar, TG; Jiang, B; Karmakar, A; Gupta, AK; Lu, Z Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=325787 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=325787&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118209038 384580752 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 640607 CCC(=O)N1CCC(CC1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C30H26F9NO4S/c1-2-26(41)40-16-14-27(15-17-40,45(42,43)22-12-10-21(31)11-13-22)19-6-8-20(9-7-19)28(29(34,35)36,30(37,38)39)44-18-23-24(32)4-3-5-25(23)33/h3-13H,2,14-18H2,1H3 LORGSXSIDKPRTH-UHFFFAOYSA-N 325789 US9637455, 5 Nuclear receptor ROR-gamma [262-507] 93.0 US Patent 10.7270/Q21R6SKX aid1796769 US9637455 Duan, J; Dhar, TG; Jiang, B; Karmakar, A; Gupta, AK; Lu, Z Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=325789 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=325789&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118219097 384580754 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 640608 COCC(=O)N1CCC(CC1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C30H26F9NO5S/c1-44-18-26(41)40-15-13-27(14-16-40,46(42,43)22-11-9-21(31)10-12-22)19-5-7-20(8-6-19)28(29(34,35)36,30(37,38)39)45-17-23-24(32)3-2-4-25(23)33/h2-12H,13-18H2,1H3 XVUFUJOWNSWXEN-UHFFFAOYSA-N 325790 US9637455, 6 Nuclear receptor ROR-gamma [262-507] 62.0 US Patent 10.7270/Q21R6SKX aid1796769 US9637455 Duan, J; Dhar, TG; Jiang, B; Karmakar, A; Gupta, AK; Lu, Z Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=325790 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=325790&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118219096 384580755 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 640609 Fc1ccc(cc1)S(=O)(=O)C1(CCN(CC1)C(=O)Cc1ccccc1)c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F InChI=1S/C35H28F9NO4S/c36-26-13-15-27(16-14-26)50(47,48)32(17-19-45(20-18-32)31(46)21-23-5-2-1-3-6-23)24-9-11-25(12-10-24)33(34(39,40)41,35(42,43)44)49-22-28-29(37)7-4-8-30(28)38/h1-16H,17-22H2 PWCPHIGRTSDJBC-UHFFFAOYSA-N 325791 US9637455, 7 Nuclear receptor ROR-gamma [262-507] 166 US Patent 10.7270/Q21R6SKX aid1796769 US9637455 Duan, J; Dhar, TG; Jiang, B; Karmakar, A; Gupta, AK; Lu, Z Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=325791 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=325791&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118219102 384580756 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 640610 NC(=O)c1ccc(CC(=O)N2CCC(CC2)(c2ccc(cc2)C(OCc2c(F)cccc2F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c2ccc(F)cc2)cc1 InChI=1S/C36H29F9N2O5S/c37-26-12-14-27(15-13-26)53(50,51)33(16-18-47(19-17-33)31(48)20-22-4-6-23(7-5-22)32(46)49)24-8-10-25(11-9-24)34(35(40,41)42,36(43,44)45)52-21-28-29(38)2-1-3-30(28)39/h1-15H,16-21H2,(H2,46,49) DAAJYMMIVOBADE-UHFFFAOYSA-N 325792 US9637455, 8 Nuclear receptor ROR-gamma [262-507] 167 US Patent 10.7270/Q21R6SKX aid1796769 US9637455 Duan, J; Dhar, TG; Jiang, B; Karmakar, A; Gupta, AK; Lu, Z Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=325792 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=325792&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118219099 384580757 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 640611 Fc1ccc(cc1)S(=O)(=O)C1(CCN(CC1)C(=O)Cc1ccc(cc1)C#N)c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F InChI=1S/C36H27F9N2O4S/c37-27-12-14-28(15-13-27)52(49,50)33(16-18-47(19-17-33)32(48)20-23-4-6-24(21-46)7-5-23)25-8-10-26(11-9-25)34(35(40,41)42,36(43,44)45)51-22-29-30(38)2-1-3-31(29)39/h1-15H,16-20,22H2 LQEARRXKDLMPFP-UHFFFAOYSA-N 325793 US9637455, 9 Nuclear receptor ROR-gamma [262-507] 1387 US Patent 10.7270/Q21R6SKX aid1796769 US9637455 Duan, J; Dhar, TG; Jiang, B; Karmakar, A; Gupta, AK; Lu, Z Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=325793 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=325793&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118219098 384580758 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 640612 Fc1ccc(cc1)S(=O)(=O)C1(CCN(CC1)C(=O)Cc1cccnc1)c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F InChI=1S/C34H27F9N2O4S/c35-25-10-12-26(13-11-25)50(47,48)31(14-17-45(18-15-31)30(46)19-22-3-2-16-44-20-22)23-6-8-24(9-7-23)32(33(38,39)40,34(41,42)43)49-21-27-28(36)4-1-5-29(27)37/h1-13,16,20H,14-15,17-19,21H2 NQGUOLYSYGXQMG-UHFFFAOYSA-N 325794 US9637455, 10 Nuclear receptor ROR-gamma [262-507] 148 US Patent 10.7270/Q21R6SKX aid1796769 US9637455 Duan, J; Dhar, TG; Jiang, B; Karmakar, A; Gupta, AK; Lu, Z Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=325794 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=325794&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118219100 384580759 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 640613 Fc1ccc(cc1)S(=O)(=O)C1(CCN(CC1)C(=O)Cc1ccncc1)c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F InChI=1S/C34H27F9N2O4S/c35-25-8-10-26(11-9-25)50(47,48)31(14-18-45(19-15-31)30(46)20-22-12-16-44-17-13-22)23-4-6-24(7-5-23)32(33(38,39)40,34(41,42)43)49-21-27-28(36)2-1-3-29(27)37/h1-13,16-17H,14-15,18-21H2 WOGJRVXQXSBCOH-UHFFFAOYSA-N 325795 US9637455, 11 Nuclear receptor ROR-gamma [262-507] 195 US Patent 10.7270/Q21R6SKX aid1796769 US9637455 Duan, J; Dhar, TG; Jiang, B; Karmakar, A; Gupta, AK; Lu, Z Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=325795 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=325795&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118219101 384580760 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 640614 Fc1ccc(cc1)S(=O)(=O)C1(CCN(CC1)C(=O)c1cccnc1)c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F InChI=1S/C33H25F9N2O4S/c34-24-10-12-25(13-11-24)49(46,47)30(14-17-44(18-15-30)29(45)21-3-2-16-43-19-21)22-6-8-23(9-7-22)31(32(37,38)39,33(40,41)42)48-20-26-27(35)4-1-5-28(26)36/h1-13,16,19H,14-15,17-18,20H2 NSSLRRJLOQECCJ-UHFFFAOYSA-N 325796 US9637455, 12 Nuclear receptor ROR-gamma [262-507] 191 US Patent 10.7270/Q21R6SKX aid1796769 US9637455 Duan, J; Dhar, TG; Jiang, B; Karmakar, A; Gupta, AK; Lu, Z Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=325796 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=325796&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118219105 384580761 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 640615 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CCC(CC1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C35H32F9NO6S/c36-25-12-14-26(15-13-25)52(49,50)32(16-18-45(19-17-32)30(46)21-4-6-22(7-5-21)31(47)48)23-8-10-24(11-9-23)33(34(39,40)41,35(42,43)44)51-20-27-28(37)2-1-3-29(27)38/h1-3,8-15,21-22H,4-7,16-20H2,(H,47,48)/t21-,22- AHBUSZXBDAMUFD-HZCBDIJESA-N 325797 US9637455, 13 Nuclear receptor ROR-gamma [262-507] 340 US Patent 10.7270/Q21R6SKX aid1796769 US9637455 Duan, J; Dhar, TG; Jiang, B; Karmakar, A; Gupta, AK; Lu, Z Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=325797 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=325797&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118219107 384580762 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 640616 CC(=O)N1CCC(CC1)C(=O)N1CCC(CC1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C35H33F9N2O5S/c1-22(47)45-17-13-23(14-18-45)31(48)46-19-15-32(16-20-46,52(49,50)27-11-9-26(36)10-12-27)24-5-7-25(8-6-24)33(34(39,40)41,35(42,43)44)51-21-28-29(37)3-2-4-30(28)38/h2-12,23H,13-21H2,1H3 SJMZMUOKJYEQQE-UHFFFAOYSA-N 325798 US9637455, 14 Nuclear receptor ROR-gamma [262-507] 314 US Patent 10.7270/Q21R6SKX aid1796769 US9637455 Duan, J; Dhar, TG; Jiang, B; Karmakar, A; Gupta, AK; Lu, Z Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=325798 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=325798&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118219103 384580763 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 640617 Fc1ccc(cc1)S(=O)(=O)C1(CCN(CC1)C(=O)C1CCOCC1)c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F InChI=1S/C33H30F9NO5S/c34-24-8-10-25(11-9-24)49(45,46)30(14-16-43(17-15-30)29(44)21-12-18-47-19-13-21)22-4-6-23(7-5-22)31(32(37,38)39,33(40,41)42)48-20-26-27(35)2-1-3-28(26)36/h1-11,21H,12-20H2 FVZFHZHEMQUFKL-UHFFFAOYSA-N 325799 US9637455, 15 Nuclear receptor ROR-gamma [262-507] 56.0 US Patent 10.7270/Q21R6SKX aid1796769 US9637455 Duan, J; Dhar, TG; Jiang, B; Karmakar, A; Gupta, AK; Lu, Z Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=325799 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=325799&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 91820658 384580764 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 640618 COC(=O)N1CCC(CC1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C29H24F9NO5S/c1-43-25(40)39-15-13-26(14-16-39,45(41,42)21-11-9-20(30)10-12-21)18-5-7-19(8-6-18)27(28(33,34)35,29(36,37)38)44-17-22-23(31)3-2-4-24(22)32/h2-12H,13-17H2,1H3 HEPMKKUDGQUYCO-UHFFFAOYSA-N 325800 US9637455, 16 Nuclear receptor ROR-gamma [262-507] 140 US Patent 10.7270/Q21R6SKX aid1796769 US9637455 Duan, J; Dhar, TG; Jiang, B; Karmakar, A; Gupta, AK; Lu, Z Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=325800 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=325800&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118219106 384580765 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 640619 Fc1ccc(cc1)S(=O)(=O)C1(CCN(CC1)C(=O)OCc1ccccc1)c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F InChI=1S/C35H28F9NO5S/c36-26-13-15-27(16-14-26)51(47,48)32(17-19-45(20-18-32)31(46)49-21-23-5-2-1-3-6-23)24-9-11-25(12-10-24)33(34(39,40)41,35(42,43)44)50-22-28-29(37)7-4-8-30(28)38/h1-16H,17-22H2 BAUZXGBARDBKEW-UHFFFAOYSA-N 325801 US9637455, 17 Nuclear receptor ROR-gamma [262-507] 488 US Patent 10.7270/Q21R6SKX aid1796769 US9637455 Duan, J; Dhar, TG; Jiang, B; Karmakar, A; Gupta, AK; Lu, Z Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=325801 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=325801&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118219104 384580766 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 640620 CCNC(=O)N1CCC(CC1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C30H27F9N2O4S/c1-2-40-26(42)41-16-14-27(15-17-41,46(43,44)22-12-10-21(31)11-13-22)19-6-8-20(9-7-19)28(29(34,35)36,30(37,38)39)45-18-23-24(32)4-3-5-25(23)33/h3-13H,2,14-18H2,1H3,(H,40,42) NRVOQMDGGNOFDF-UHFFFAOYSA-N 325802 US9637455, 18 Nuclear receptor ROR-gamma [262-507] 63.0 US Patent 10.7270/Q21R6SKX aid1796769 US9637455 Duan, J; Dhar, TG; Jiang, B; Karmakar, A; Gupta, AK; Lu, Z Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=325802 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=325802&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118219109 384580767 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 640621 CC(C)(C)NC(=O)N1CCC(CC1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C32H31F9N2O4S/c1-28(2,3)42-27(44)43-17-15-29(16-18-43,48(45,46)23-13-11-22(33)12-14-23)20-7-9-21(10-8-20)30(31(36,37)38,32(39,40)41)47-19-24-25(34)5-4-6-26(24)35/h4-14H,15-19H2,1-3H3,(H,42,44) SAFZJDJLMHBODJ-UHFFFAOYSA-N 325803 US9637455, 19 Nuclear receptor ROR-gamma [262-507] 128 US Patent 10.7270/Q21R6SKX aid1796769 US9637455 Duan, J; Dhar, TG; Jiang, B; Karmakar, A; Gupta, AK; Lu, Z Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=325803 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=325803&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118219108 384580768 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 640622 Fc1ccc(cc1)S(=O)(=O)C1(CCN(CC1)C(=O)Nc1ccncc1)c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F InChI=1S/C33H26F9N3O4S/c34-23-8-10-25(11-9-23)50(47,48)30(14-18-45(19-15-30)29(46)44-24-12-16-43-17-13-24)21-4-6-22(7-5-21)31(32(37,38)39,33(40,41)42)49-20-26-27(35)2-1-3-28(26)36/h1-13,16-17H,14-15,18-20H2,(H,43,44,46) VXCNAXGSSGCKPX-UHFFFAOYSA-N 325804 US9637455, 20 Nuclear receptor ROR-gamma [262-507] 93.0 US Patent 10.7270/Q21R6SKX aid1796769 US9637455 Duan, J; Dhar, TG; Jiang, B; Karmakar, A; Gupta, AK; Lu, Z Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=325804 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=325804&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118219071 384580769 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 640623 CS(=O)(=O)N1CCC(CC1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H24F9NO5S2/c1-44(39,40)38-15-13-25(14-16-38,45(41,42)21-11-9-20(29)10-12-21)18-5-7-19(8-6-18)26(27(32,33)34,28(35,36)37)43-17-22-23(30)3-2-4-24(22)31/h2-12H,13-17H2,1H3 FSKOLIJAFIURGL-UHFFFAOYSA-N 325805 US9637455, 21 Nuclear receptor ROR-gamma [262-507] 118 US Patent 10.7270/Q21R6SKX aid1796769 US9637455 Duan, J; Dhar, TG; Jiang, B; Karmakar, A; Gupta, AK; Lu, Z Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=325805 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=325805&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 118219073 384580770 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643513 OC(c1ccc2N([C@H](CC(=O)NCC3CNC(=O)O3)CCc2c1)S(=O)(=O)c1ccc(F)cc1)(C(F)(F)F)C(F)(F)F InChI=1S/C24H22F7N3O6S/c25-15-3-6-18(7-4-15)41(38,39)34-16(10-20(35)32-11-17-12-33-21(36)40-17)5-1-13-9-14(2-8-19(13)34)22(37,23(26,27)28)24(29,30)31/h2-4,6-9,16-17,37H,1,5,10-12H2,(H,32,35)(H,33,36)/t16-,17?/m0/s1 LBZVVMJHAQYJQJ-BHWOMJMDSA-N 327449 2-((S)-1-((4-fluorophenyl)sulfonyl)-6-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,2,3,4-tetrahydroquinolin-2-yl)-N-((2-oxooxazolidin-5-yl)methyl)acetamide::US9663469, 1 Nuclear receptor ROR-gamma [262-507] 16.7 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327449 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327449&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117949975 384582393 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643514 CC(C)(N)CNC(=O)C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C24H26F7N3O4S/c1-21(2,32)13-33-20(35)12-17-7-3-14-11-15(22(36,23(26,27)28)24(29,30)31)4-10-19(14)34(17)39(37,38)18-8-5-16(25)6-9-18/h4-6,8-11,17,36H,3,7,12-13,32H2,1-2H3,(H,33,35)/t17-/m0/s1 MZAQVKDRIUVRCM-KRWDZBQOSA-N 327450 (S)—N-(2-amino-2-methylpropyl)-2-(1-((4-fluorophenyl)sulfonyl)-6-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,2,3,4-tetrahydroquinolin-2-yl)acetamide::US9663469, 2 Nuclear receptor ROR-gamma [262-507] 48.5 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327450 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327450&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117940676 384582394 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643515 CN(CC(C)(C)O)C(=O)C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C25H27F7N2O5S/c1-22(2,36)14-33(3)21(35)13-18-8-4-15-12-16(23(37,24(27,28)29)25(30,31)32)5-11-20(15)34(18)40(38,39)19-9-6-17(26)7-10-19/h5-7,9-12,18,36-37H,4,8,13-14H2,1-3H3/t18-/m0/s1 ITDBJRVRXPTXKJ-SFHVURJKSA-N 327451 (S)-2-(1-((4-fluorophenyl)sulfonyl)-6-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,2,3,4-tetrahydroquinolin-2-yl)-N-(2-hydroxy-2-methylpropyl)-N-methylacetamide::US9663469, 3 Nuclear receptor ROR-gamma [262-507] 29.3 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327451 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327451&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117940686 384582395 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643516 CC(C)(C)OC(=O)N[C@@H]1CCN(C1)C(=O)C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C29H32F7N3O6S/c1-26(2,3)45-25(41)37-20-12-13-38(16-20)24(40)15-21-8-4-17-14-18(27(42,28(31,32)33)29(34,35)36)5-11-23(17)39(21)46(43,44)22-9-6-19(30)7-10-22/h5-7,9-11,14,20-21,42H,4,8,12-13,15-16H2,1-3H3,(H,37,41)/t20-,21+/m1/s1 QPMZNWITXALVDE-RTWAWAEBSA-N 327452 Tert-butyl ((R)-1-(2-((S)-1-((4-fluorophenyl)sulfonyl)-6-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,2,3,4-tetrahydroquinolin-2-yl)acetyl)pyrrolidin-3-yl)carbamate::US9663469, 4 Nuclear receptor ROR-gamma [262-507] 71.1 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327452 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327452&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117949992 384582396 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643517 O[C@@H]1CCN(C1)C(=O)C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C24H23F7N2O5S/c25-16-3-6-19(7-4-16)39(37,38)33-17(12-21(35)32-10-9-18(34)13-32)5-1-14-11-15(2-8-20(14)33)22(36,23(26,27)28)24(29,30)31/h2-4,6-8,11,17-18,34,36H,1,5,9-10,12-13H2/t17-,18+/m0/s1 GSTDINZZKFXQTI-ZWKOTPCHSA-N 327454 2-((S)-1-((4-fluorophenyl)sulfonyl)-6-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,2,3,4-tetrahydroquinolin-2-yl)-1-((R)-3-hydroxypyrrolidin-1-yl)ethanone::US9663469, 5 Nuclear receptor ROR-gamma [262-507] 24.3 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327454 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327454&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117950112 384582398 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643518 CC(C)(C)OC(=O)N[C@H]1CCN(C1)C(=O)C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C29H32F7N3O6S/c1-26(2,3)45-25(41)37-20-12-13-38(16-20)24(40)15-21-8-4-17-14-18(27(42,28(31,32)33)29(34,35)36)5-11-23(17)39(21)46(43,44)22-9-6-19(30)7-10-22/h5-7,9-11,14,20-21,42H,4,8,12-13,15-16H2,1-3H3,(H,37,41)/t20-,21-/m0/s1 QPMZNWITXALVDE-SFTDATJTSA-N 327455 Tert-butyl ((S)-1-(2-((S)-1-((4-fluorophenyl)sulfonyl)-6-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,2,3,4-tetrahydroquinolin-2-yl)acetyl)pyrrolidin-3-yl)carbamate::US9663469, 6 Nuclear receptor ROR-gamma [262-507] 34.5 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327455 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327455&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117949991 384582399 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643519 O[C@H]1CCN(C1)C(=O)C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C24H23F7N2O5S/c25-16-3-6-19(7-4-16)39(37,38)33-17(12-21(35)32-10-9-18(34)13-32)5-1-14-11-15(2-8-20(14)33)22(36,23(26,27)28)24(29,30)31/h2-4,6-8,11,17-18,34,36H,1,5,9-10,12-13H2/t17-,18-/m0/s1 GSTDINZZKFXQTI-ROUUACIJSA-N 327459 2-((S)-1-((4-fluorophenyl)sulfonyl)-6-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,2,3,4-tetrahydroquinolin-2-yl)-1-((S)-3-hydroxypyrrolidin-1-yl)ethanone::US9663469, 7 Nuclear receptor ROR-gamma [262-507] 25.8 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327459 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327459&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117950133 384582403 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643520 CC1(CNC(=O)C[C@@H]2CCc3cc(ccc3N2S(=O)(=O)c2ccc(F)cc2)C(O)(C(F)(F)F)C(F)(F)F)NC(=O)NC1=O InChI=1S/C25H23F7N4O6S/c1-22(20(38)34-21(39)35-22)12-33-19(37)11-16-6-2-13-10-14(23(40,24(27,28)29)25(30,31)32)3-9-18(13)36(16)43(41,42)17-7-4-15(26)5-8-17/h3-5,7-10,16,40H,2,6,11-12H2,1H3,(H,33,37)(H2,34,35,38,39)/t16-,22?/m0/s1 LKFUEJLMOOSAOD-CISYCMJJSA-N 327463 2-((S)-1-((4-fluorophenyl)sulfonyl)-6-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,2,3,4-tetrahydroquinolin-2-yl)-N-((4-methyl-2,5-dioxoimidazolidin-4-yl)methyl)acetamide::US9663469, 8 Nuclear receptor ROR-gamma [262-507] 55.8 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327463 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327463&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117940740 384582407 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643521 OC(c1ccc2N([C@H](CC(=O)N3CCC4(CC3)NC(=O)NC4=O)CCc2c1)S(=O)(=O)c1ccc(F)cc1)(C(F)(F)F)C(F)(F)F InChI=1S/C27H25F7N4O6S/c28-17-3-6-19(7-4-17)45(43,44)38-18(14-21(39)37-11-9-24(10-12-37)22(40)35-23(41)36-24)5-1-15-13-16(2-8-20(15)38)25(42,26(29,30)31)27(32,33)34/h2-4,6-8,13,18,42H,1,5,9-12,14H2,(H2,35,36,40,41)/t18-/m0/s1 KNWUZYSNKFGSBP-SFHVURJKSA-N 327468 (S)-8-(2-(1-((4-fluorophenyl)sulfonyl)-6-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,2,3,4-tetrahydroquinolin-2-yl)acetyl)-1,3,8-triazaspiro[4.5]decane-2,4-dione::US9663469, 9 Nuclear receptor ROR-gamma [262-507] 24.4 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327468 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327468&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117949973 384582412 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643522 OC(c1ccc2N([C@H](CC(=O)N3CCC4(C3)NC(=O)NC4=O)CCc2c1)S(=O)(=O)c1ccc(F)cc1)(C(F)(F)F)C(F)(F)F InChI=1S/C26H23F7N4O6S/c27-16-3-6-18(7-4-16)44(42,43)37-17(12-20(38)36-10-9-23(13-36)21(39)34-22(40)35-23)5-1-14-11-15(2-8-19(14)37)24(41,25(28,29)30)26(31,32)33/h2-4,6-8,11,17,41H,1,5,9-10,12-13H2,(H2,34,35,39,40)/t17-,23?/m0/s1 SLNICQZZTIMVDU-NVHKAFQKSA-N 327469 7-(2-((S)-1-((4-fluorophenyl)sulfonyl)-6-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,2,3,4-tetrahydroquinolin-2-yl)acetyl)-1,3,7-triazaspiro[4.4]nonane-2,4-dione::US9663469, 10 Nuclear receptor ROR-gamma [262-507] 31.0 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327469 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327469&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117940965 384582413 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643523 N[C@@H]1CCN(C1)C(=O)C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C24H24F7N3O4S/c25-16-3-6-19(7-4-16)39(37,38)34-18(12-21(35)33-10-9-17(32)13-33)5-1-14-11-15(2-8-20(14)34)22(36,23(26,27)28)24(29,30)31/h2-4,6-8,11,17-18,36H,1,5,9-10,12-13,32H2/t17-,18+/m1/s1 WOOJYBRETVZTMI-MSOLQXFVSA-N 327470 1-((R)-3-aminopyrrolidin-1-yl)-2-((S)-1-((4-fluorophenyl)sulfonyl)-6-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,2,3,4-tetrahydroquinolin-2-yl)ethanone::US9663469, 11 Nuclear receptor ROR-gamma [262-507] 62.9 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327470 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327470&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117940702 384582414 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643524 N[C@H]1CCN(C1)C(=O)C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C24H24F7N3O4S/c25-16-3-6-19(7-4-16)39(37,38)34-18(12-21(35)33-10-9-17(32)13-33)5-1-14-11-15(2-8-20(14)34)22(36,23(26,27)28)24(29,30)31/h2-4,6-8,11,17-18,36H,1,5,9-10,12-13,32H2/t17-,18-/m0/s1 WOOJYBRETVZTMI-ROUUACIJSA-N 327471 1-((S)-3-aminopyrrolidin-1-yl)-2-((S)-1-((4-fluorophenyl)sulfonyl)-6-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,2,3,4-tetrahydroquinolin-2-yl)ethanone::US9663469, 12 Nuclear receptor ROR-gamma [262-507] 124 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327471 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327471&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117940707 384582415 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643525 OC(c1ccc2N([C@H](CC(=O)NCC3(NC(=O)NC3=O)C3CCCO3)CCc2c1)S(=O)(=O)c1ccc(F)cc1)(C(F)(F)F)C(F)(F)F InChI=1S/C28H27F7N4O7S/c29-17-5-8-19(9-6-17)47(44,45)39-18(13-22(40)36-14-25(21-2-1-11-46-21)23(41)37-24(42)38-25)7-3-15-12-16(4-10-20(15)39)26(43,27(30,31)32)28(33,34)35/h4-6,8-10,12,18,21,43H,1-3,7,11,13-14H2,(H,36,40)(H2,37,38,41,42)/t18-,21?,25?/m0/s1 LEDXILLOVKJOND-HHIIEYADSA-N 327472 N-((2,5-dioxo-4-(tetrahydrofuran-2-yl)imidazolidin-4-yl)methyl)-2-((S)-1-((4-fluorophenyl)sulfonyl)-6-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,2,3,4-tetrahydroquinolin-2-yl)acetamide::US9663469, 13 Nuclear receptor ROR-gamma [262-507] 59.1 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327472 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327472&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117940693 384582416 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643526 CC(C)(O)[C@H](F)CNC(=O)C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C25H26F8N2O5S/c1-22(2,37)20(27)13-34-21(36)12-17-7-3-14-11-15(23(38,24(28,29)30)25(31,32)33)4-10-19(14)35(17)41(39,40)18-8-5-16(26)6-9-18/h4-6,8-11,17,20,37-38H,3,7,12-13H2,1-2H3,(H,34,36)/t17-,20+/m0/s1 FQWMGYJHFABALZ-FXAWDEMLSA-N 327473 N—((S)-2-fluoro-3-hydroxy-3-methylbutyl)-2-((S)-1-((4-fluorophenyl)sulfonyl)-6-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,2,3,4-tetrahydroquinolin-2-yl)acetamide::US9663469, 14 Nuclear receptor ROR-gamma [262-507] 22.1 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327473 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327473&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117949985 384582417 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643527 CC1(CNC(=O)C[C@@H]2CCc3cc(ccc3N2S(=O)(=O)c2ccc(F)cc2)C(O)(C(F)(F)F)C(F)(F)F)COC(=O)N1 InChI=1S/C25H24F7N3O6S/c1-22(13-41-21(37)34-22)12-33-20(36)11-17-6-2-14-10-15(23(38,24(27,28)29)25(30,31)32)3-9-19(14)35(17)42(39,40)18-7-4-16(26)5-8-18/h3-5,7-10,17,38H,2,6,11-13H2,1H3,(H,33,36)(H,34,37)/t17-,22?/m0/s1 JBNGJIIHIKHGSS-LBOXEOMUSA-N 327474 2-((S)-1-((4-fluorophenyl)sulfonyl)-6-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,2,3,4-tetrahydroquinolin-2-yl)-N-((4-methyl-2-oxooxazolidin-4-yl)methyl)acetamide::US9663469, 15 Nuclear receptor ROR-gamma [262-507] 17.4 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327474 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327474&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117940779 384582418 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643528 CC(=O)NC(C)(C)CNC(=O)C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C26H28F7N3O5S/c1-15(37)35-23(2,3)14-34-22(38)13-19-8-4-16-12-17(24(39,25(28,29)30)26(31,32)33)5-11-21(16)36(19)42(40,41)20-9-6-18(27)7-10-20/h5-7,9-12,19,39H,4,8,13-14H2,1-3H3,(H,34,38)(H,35,37)/t19-/m0/s1 WJIVFPNORAWSDM-IBGZPJMESA-N 327475 (S)—N-(2-acetamido-2-methylpropyl)-2-(1-((4-fluorophenyl)sulfonyl)-6-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,2,3,4-tetrahydroquinolin-2-yl)acetamide::US9663469, 16 Nuclear receptor ROR-gamma [262-507] 47.6 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327475 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327475&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122652371 384582419 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643529 C[C@@]1(O)CN(C[C@H]1NC(=O)C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F)C(=O)OCc1ccccc1 InChI=1S/C33H32F7N3O7S/c1-30(46)19-42(29(45)50-18-20-5-3-2-4-6-20)17-27(30)41-28(44)16-24-11-7-21-15-22(31(47,32(35,36)37)33(38,39)40)8-14-26(21)43(24)51(48,49)25-12-9-23(34)10-13-25/h2-6,8-10,12-15,24,27,46-47H,7,11,16-19H2,1H3,(H,41,44)/t24-,27+,30+/m0/s1 WIUPPWPKAYNNHG-FHFHAPQWSA-N 327476 (3R,4R)-benzyl 4-(2-((S)-1-((4-fluorophenyl)sulfonyl)-6-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,2,3,4-tetrahydroquinolin-2-yl)acetamido)-3-hydroxy-3-methylpyrrolidine-1-carboxylate::US9663469, 17 Nuclear receptor ROR-gamma [262-507] 110 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327476 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327476&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122662284 384582420 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643530 C[C@@]1(O)CNC[C@H]1NC(=O)C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C25H26F7N3O5S/c1-22(37)13-33-12-20(22)34-21(36)11-17-6-2-14-10-15(23(38,24(27,28)29)25(30,31)32)3-9-19(14)35(17)41(39,40)18-7-4-16(26)5-8-18/h3-5,7-10,17,20,33,37-38H,2,6,11-13H2,1H3,(H,34,36)/t17-,20+,22+/m0/s1 RLGPHJYRKNQCPW-UCNVEGJOSA-N 327477 2-((S)-1-((4-fluorophenyl)sulfonyl)-6-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,2,3,4-tetrahydroquinolin-2-yl)-N-((3R,4R)-4-hydroxy-4-methylpyrrolidin-3-yl)acetamide::US9663469, 18 Nuclear receptor ROR-gamma [262-507] 189 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327477 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327477&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117940966 384582421 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643531 CN1C[C@@H](NC(=O)C[C@@H]2CCc3cc(ccc3N2S(=O)(=O)c2ccc(F)cc2)C(O)(C(F)(F)F)C(F)(F)F)[C@](C)(O)C1 InChI=1S/C26H28F7N3O5S/c1-23(38)14-35(2)13-21(23)34-22(37)12-18-7-3-15-11-16(24(39,25(28,29)30)26(31,32)33)4-10-20(15)36(18)42(40,41)19-8-5-17(27)6-9-19/h4-6,8-11,18,21,38-39H,3,7,12-14H2,1-2H3,(H,34,37)/t18-,21+,23+/m0/s1 GYXRGMAOYRYZET-QTGUNEKASA-N 327478 2-((S)-1-((4-fluorophenyl)sulfonyl)-6-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,2,3,4-tetrahydroquinolin-2-yl)-N-((3R,4R)-4-hydroxy-1,4-dimethylpyrrolidin-3-yl)acetamide::US9663469, 19 Nuclear receptor ROR-gamma [262-507] 103 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327478 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327478&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117941067 384582422 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643532 CC(=O)N1C[C@@H](NC(=O)C[C@@H]2CCc3cc(ccc3N2S(=O)(=O)c2ccc(F)cc2)C(O)(C(F)(F)F)C(F)(F)F)[C@](C)(O)C1 InChI=1S/C27H28F7N3O6S/c1-15(38)36-13-22(24(2,40)14-36)35-23(39)12-19-7-3-16-11-17(25(41,26(29,30)31)27(32,33)34)4-10-21(16)37(19)44(42,43)20-8-5-18(28)6-9-20/h4-6,8-11,19,22,40-41H,3,7,12-14H2,1-2H3,(H,35,39)/t19-,22+,24+/m0/s1 IBURFKSZJPJFNP-BPUDTRNYSA-N 327479 N-((3R,4R)-1-acetyl-4-hydroxy-4-methylpyrrolidin-3-yl)-2-((S)-1-((4-fluorophenyl)sulfonyl)-6-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,2,3,4-tetrahydroquinolin-2-yl)acetamide::US9663469, 20 Nuclear receptor ROR-gamma [262-507] 117 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327479 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327479&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117940614 384582423 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643533 CC1(CNC(=O)C[C@@H]2CCc3cc(ccc3N2S(=O)(=O)c2ccc(F)cc2)C(O)(C(F)(F)F)C(F)(F)F)CNC(=O)O1 InChI=1S/C25H24F7N3O6S/c1-22(13-34-21(37)41-22)12-33-20(36)11-17-6-2-14-10-15(23(38,24(27,28)29)25(30,31)32)3-9-19(14)35(17)42(39,40)18-7-4-16(26)5-8-18/h3-5,7-10,17,38H,2,6,11-13H2,1H3,(H,33,36)(H,34,37)/t17-,22?/m0/s1 ALKCVHQIPZMGTP-LBOXEOMUSA-N 327480 2-((S)-1-((4-fluorophenyl)sulfonyl)-6-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,2,3,4-tetrahydroquinolin-2-yl)-N-((5-methyl-2-oxooxazolidin-5-yl)methyl)acetamide::US9663469, 21 Nuclear receptor ROR-gamma [262-507] 14.4 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327480 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327480&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117941094 384582424 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643534 OC(c1ccc2N([C@H](CC(=O)N[C@@H]3CNC[C@H]3CF)CCc2c1)S(=O)(=O)c1ccc(F)cc1)(C(F)(F)F)C(F)(F)F InChI=1S/C25H25F8N3O4S/c26-11-15-12-34-13-20(15)35-22(37)10-18-5-1-14-9-16(23(38,24(28,29)30)25(31,32)33)2-8-21(14)36(18)41(39,40)19-6-3-17(27)4-7-19/h2-4,6-9,15,18,20,34,38H,1,5,10-13H2,(H,35,37)/t15-,18+,20-/m1/s1 MHYXUPWNHQYTLF-MOXGXCLJSA-N 327481 N-((3R,4R)-4-(fluoromethyl)pyrrolidin-3-yl)-2-((S)-1-((4-fluorophenyl)sulfonyl)-6-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,2,3,4-tetrahydroquinolin-2-yl)acetamide::US9663469, 22 Nuclear receptor ROR-gamma [262-507] 51.5 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327481 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327481&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 129167164 384582425 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643535 C[C@@]1(N)CC[C@H](NC(=O)C[C@@H]2CCc3cc(ccc3N2S(=O)(=O)c2ccc(F)cc2)C(O)(C(F)(F)F)C(F)(F)F)C1(C)C InChI=1S/C28H32F7N3O4S/c1-24(2)22(12-13-25(24,3)36)37-23(39)15-19-8-4-16-14-17(26(40,27(30,31)32)28(33,34)35)5-11-21(16)38(19)43(41,42)20-9-6-18(29)7-10-20/h5-7,9-11,14,19,22,40H,4,8,12-13,15,36H2,1-3H3,(H,37,39)/t19-,22-,25+/m0/s1 RDVOPTXVWXIKIK-KIVTUJJHSA-N 327482 N-((1S,3R)-3-amino-2,2,3-trimethylcyclopentyl)-2-((S)-1-((4-fluorophenyl)sulfonyl)-6-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,2,3,4-tetrahydroquinolin-2-yl)acetamide::US9663469, 23 Nuclear receptor ROR-gamma [262-507] 69.0 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327482 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327482&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122652410 384582426 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643536 N[C@H]1CN(C[C@H]1CF)C(=O)C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C25H25F8N3O4S/c26-11-15-12-35(13-20(15)34)22(37)10-18-5-1-14-9-16(23(38,24(28,29)30)25(31,32)33)2-8-21(14)36(18)41(39,40)19-6-3-17(27)4-7-19/h2-4,6-9,15,18,20,38H,1,5,10-13,34H2/t15-,18+,20+/m1/s1 OWQWDYMPUMGARG-BPAFIMBUSA-N 327483 1-((3R,4R)-3-amino-4-(fluoromethyl)pyrrolidin-1-yl)-2-((S)-1-((4-fluorophenyl)sulfonyl)-6-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,2,3,4-tetrahydroquinolin-2-yl)ethanone::US9663469, 24 Nuclear receptor ROR-gamma [262-507] 28.6 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327483 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327483&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117940619 384582427 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643537 C[C@]1(O)CC[C@H](NC(=O)C[C@@H]2CCc3cc(ccc3N2S(=O)(=O)c2ccc(F)cc2)C(O)(C(F)(F)F)C(F)(F)F)C1(C)C InChI=1S/C28H31F7N2O5S/c1-24(2)22(12-13-25(24,3)39)36-23(38)15-19-8-4-16-14-17(26(40,27(30,31)32)28(33,34)35)5-11-21(16)37(19)43(41,42)20-9-6-18(29)7-10-20/h5-7,9-11,14,19,22,39-40H,4,8,12-13,15H2,1-3H3,(H,36,38)/t19-,22-,25-/m0/s1 VRJBRDGTBPYAGF-JTJYXVOQSA-N 327484 2-((S)-1-((4-fluorophenyl)sulfonyl)-6-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,2,3,4-tetrahydroquinolin-2-yl)-N-((1S,3S)-3-hydroxy-2,2,3-trimethylcyclopentyl)acetamide::US9663469, 25 Nuclear receptor ROR-gamma [262-507] 30.8 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327484 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327484&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122652345 384582428 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643538 NC(=O)[C@@H]1CC(F)(F)CN1C(=O)C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C25H22F9N3O5S/c26-15-3-6-17(7-4-15)43(41,42)37-16(10-20(38)36-12-22(27,28)11-19(36)21(35)39)5-1-13-9-14(2-8-18(13)37)23(40,24(29,30)31)25(32,33)34/h2-4,6-9,16,19,40H,1,5,10-12H2,(H2,35,39)/t16-,19-/m0/s1 ZHESBASGZWYEJE-LPHOPBHVSA-N 327485 (S)-4,4-difluoro-1-(2-((S)-1-((4-fluorophenyl)sulfonyl)-6-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,2,3,4-tetrahydroquinolin-2-yl)acetyl)pyrrolidine-2-carboxamide::US9663469, 26 Nuclear receptor ROR-gamma [262-507] 45.0 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327485 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327485&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117949994 384582429 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643539 CN1C(=O)NC(C)(CNC(=O)C[C@@H]2CCc3cc(ccc3N2S(=O)(=O)c2ccc(F)cc2)C(O)(C(F)(F)F)C(F)(F)F)C1=O InChI=1S/C26H25F7N4O6S/c1-23(21(39)36(2)22(40)35-23)13-34-20(38)12-17-7-3-14-11-15(24(41,25(28,29)30)26(31,32)33)4-10-19(14)37(17)44(42,43)18-8-5-16(27)6-9-18/h4-6,8-11,17,41H,3,7,12-13H2,1-2H3,(H,34,38)(H,35,40)/t17-,23?/m0/s1 KZTWZXGWLYKGMJ-NVHKAFQKSA-N 327486 N-(1,4-dimethyl-2,5-dioxoimidazolidin-4-yl)methyl)-2-((S)-1-((4-fluorophenyl)sulfonyl)-6-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,2,3,4-tetrahydroquinolin-2-yl)acetamide::US9663469, 27 Nuclear receptor ROR-gamma [262-507] 50.6 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327486 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327486&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117940682 384582430 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643540 CCNC(=O)N[C@H]1CCN(C1)C(=O)C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C27H29F7N4O5S/c1-2-35-24(40)36-19-11-12-37(15-19)23(39)14-20-7-3-16-13-17(25(41,26(29,30)31)27(32,33)34)4-10-22(16)38(20)44(42,43)21-8-5-18(28)6-9-21/h4-6,8-10,13,19-20,41H,2-3,7,11-12,14-15H2,1H3,(H2,35,36,40)/t19-,20-/m0/s1 ZYIJHWXUSBZRQN-PMACEKPBSA-N 327487 1-ethyl-3-((S)-1-(2-((S)-1-((4-fluorophenyl)sulfonyl)-6-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,2,3,4-tetrahydroquinolin-2-yl)acetyl)pyrrolidin-3-yl)urea::US9663469, 28 Nuclear receptor ROR-gamma [262-507] 28.0 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327487 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327487&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117950132 384582431 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643541 COC(=O)N[C@H]1CCN(C1)C(=O)C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C26H26F7N3O6S/c1-42-23(38)34-18-10-11-35(14-18)22(37)13-19-6-2-15-12-16(24(39,25(28,29)30)26(31,32)33)3-9-21(15)36(19)43(40,41)20-7-4-17(27)5-8-20/h3-5,7-9,12,18-19,39H,2,6,10-11,13-14H2,1H3,(H,34,38)/t18-,19-/m0/s1 UCNJATLLECDEOP-OALUTQOASA-N 327488 Methyl ((S)-1-(2-((S)-1-((4-fluorophenyl)sulfonyl)-6-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,2,3,4-tetrahydroquinolin-2-yl)acetyl)pyrrolidin-3-yl)carbamate::US9663469, 29 Nuclear receptor ROR-gamma [262-507] 57.1 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327488 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327488&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117949998 384582432 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643542 CC1(CNC(=O)C[C@@H]2CCc3cc(ccc3N2S(=O)(=O)c2ccc(F)cc2)C(O)(C(F)(F)F)C(F)(F)F)CNC(=O)N1 InChI=1S/C25H25F7N4O5S/c1-22(13-34-21(38)35-22)12-33-20(37)11-17-6-2-14-10-15(23(39,24(27,28)29)25(30,31)32)3-9-19(14)36(17)42(40,41)18-7-4-16(26)5-8-18/h3-5,7-10,17,39H,2,6,11-13H2,1H3,(H,33,37)(H2,34,35,38)/t17-,22?/m0/s1 WXPRNAPFMYHTGN-LBOXEOMUSA-N 327489 2-((S)-1-((4-fluorophenyl)sulfonyl)-6-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,2,3,4-tetrahydroquinolin-2-yl)-N-((4-methyl-2-oxoimidazolidin-4-yl)methyl)acetamide::US9663469, 30 Nuclear receptor ROR-gamma [262-507] 54.2 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327489 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327489&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117940959 384582433 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643543 OC(c1ccc2N([C@H](CC(=O)N3CCC(=O)N3)CCc2c1)S(=O)(=O)c1ccc(F)cc1)(C(F)(F)F)C(F)(F)F InChI=1S/C23H20F7N3O5S/c24-15-3-6-17(7-4-15)39(37,38)33-16(12-20(35)32-10-9-19(34)31-32)5-1-13-11-14(2-8-18(13)33)21(36,22(25,26)27)23(28,29)30/h2-4,6-8,11,16,36H,1,5,9-10,12H2,(H,31,34)/t16-/m0/s1 YEIZWXKWIDQIRE-INIZCTEOSA-N 327490 (S)-1-(2-(1-((4-fluorophenyl)sulfonyl)-6-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,2,3,4-tetrahydroquinolin-2-yl)acetyl)pyrazolidin-3-one::US9663469, 31 Nuclear receptor ROR-gamma [262-507] 167 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327490 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327490&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117949980 384582434 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643544 COC(=O)N[C@H]1CN(CC[C@H]1O)C(=O)C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C27H28F7N3O7S/c1-44-24(40)35-20-14-36(11-10-22(20)38)23(39)13-18-6-2-15-12-16(25(41,26(29,30)31)27(32,33)34)3-9-21(15)37(18)45(42,43)19-7-4-17(28)5-8-19/h3-5,7-9,12,18,20,22,38,41H,2,6,10-11,13-14H2,1H3,(H,35,40)/t18-,20-,22+/m0/s1 SCABNUSDCCYFAX-RCZSKKKRSA-N 327491 Methyl (trans-(2-((S)-1-((4-fluorophenyl)sulfonyl)-6-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,2,3,4-tetrahydroquinolin-2-yl)acetyl)-4-hydroxypiperidin-3-yl)carbamate::US9663469, 32 Nuclear receptor ROR-gamma [262-507] 33.0 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327491 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327491&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122662302 384582435 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643545 CN1CCN(CC1=O)C(=O)C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C25H24F7N3O5S/c1-33-10-11-34(14-22(33)37)21(36)13-18-6-2-15-12-16(23(38,24(27,28)29)25(30,31)32)3-9-20(15)35(18)41(39,40)19-7-4-17(26)5-8-19/h3-5,7-9,12,18,38H,2,6,10-11,13-14H2,1H3/t18-/m0/s1 FNHQYQAQYUJBTC-SFHVURJKSA-N 327492 (S)-4-(2-(1-((4-fluorophenyl)sulfonyl)-6-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,2,3,4-tetrahydroquinolin-2-yl)acetyl)-1-methylpiperazin-2-one::US9663469, 33 Nuclear receptor ROR-gamma [262-507] 29.6 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327492 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327492&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117950155 384582436 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643546 OC(c1ccc2N([C@H](CC(=O)N3CNC(=O)C3)CCc2c1)S(=O)(=O)c1ccc(F)cc1)(C(F)(F)F)C(F)(F)F InChI=1S/C23H20F7N3O5S/c24-15-3-6-17(7-4-15)39(37,38)33-16(10-20(35)32-11-19(34)31-12-32)5-1-13-9-14(2-8-18(13)33)21(36,22(25,26)27)23(28,29)30/h2-4,6-9,16,36H,1,5,10-12H2,(H,31,34)/t16-/m0/s1 MRRBXYSCEJOJBQ-INIZCTEOSA-N 327493 (S)-1-(2-(1-((4-fluorophenyl)sulfonyl)-6-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,2,3,4-tetrahydroquinolin-2-yl)acetyl)imidazolidin-4-one::US9663469, 34 Nuclear receptor ROR-gamma [262-507] 26.6 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327493 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327493&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117949978 384582437 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643547 OC(c1ccc2N([C@H](CC(=O)N3CCNC(=O)C3)CCc2c1)S(=O)(=O)c1ccc(F)cc1)(C(F)(F)F)C(F)(F)F InChI=1S/C24H22F7N3O5S/c25-16-3-6-18(7-4-16)40(38,39)34-17(12-21(36)33-10-9-32-20(35)13-33)5-1-14-11-15(2-8-19(14)34)22(37,23(26,27)28)24(29,30)31/h2-4,6-8,11,17,37H,1,5,9-10,12-13H2,(H,32,35)/t17-/m0/s1 GOYGXUBMHNNAHN-KRWDZBQOSA-N 327494 (S)-4-(2-(1-((4-fluorophenyl)sulfonyl)-6-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,2,3,4-tetrahydroquinolin-2-yl)acetyl)piperazin-2-one::US9663469, 35 Nuclear receptor ROR-gamma [262-507] 26.2 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327494 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327494&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117940845 384582438 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643548 OC(c1ccc2N([C@H](CC(=O)NC3CNC(=O)C3)CCc2c1)S(=O)(=O)c1ccc(F)cc1)(C(F)(F)F)C(F)(F)F InChI=1S/C24H22F7N3O5S/c25-15-3-6-18(7-4-15)40(38,39)34-17(11-21(36)33-16-10-20(35)32-12-16)5-1-13-9-14(2-8-19(13)34)22(37,23(26,27)28)24(29,30)31/h2-4,6-9,16-17,37H,1,5,10-12H2,(H,32,35)(H,33,36)/t16?,17-/m0/s1 JUGUQACETMFSGX-DJNXLDHESA-N 327495 2-((S)-1-((4-fluorophenyl)sulfonyl)-6-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,2,3,4-tetrahydroquinolin-2-yl)-N-(5-oxopyrrolidin-3-yl)acetamide::US9663469, 36 Nuclear receptor ROR-gamma [262-507] 32.8 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327495 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327495&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117940585 384582439 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643549 CC1(C)OC(=O)CC1NC(=O)C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C26H25F7N2O6S/c1-23(2)20(13-22(37)41-23)34-21(36)12-17-7-3-14-11-15(24(38,25(28,29)30)26(31,32)33)4-10-19(14)35(17)42(39,40)18-8-5-16(27)6-9-18/h4-6,8-11,17,20,38H,3,7,12-13H2,1-2H3,(H,34,36)/t17-,20?/m0/s1 SWCLPVNIFRSXBL-DIMJTDRSSA-N 327496 US9663469, 37A Nuclear receptor ROR-gamma [262-507] 27.8 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327496 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327496&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122652480 384582440 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643550 CC1(C)OC(=O)CC1NC(=O)C[C@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C26H25F7N2O6S/c1-23(2)20(13-22(37)41-23)34-21(36)12-17-7-3-14-11-15(24(38,25(28,29)30)26(31,32)33)4-10-19(14)35(17)42(39,40)18-8-5-16(27)6-9-18/h4-6,8-11,17,20,38H,3,7,12-13H2,1-2H3,(H,34,36)/t17-,20?/m1/s1 SWCLPVNIFRSXBL-DIAVIDTQSA-N 327497 US9663469, 37B Nuclear receptor ROR-gamma [262-507] 20.7 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327497 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327497&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 138404123 384582441 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643551 OC(c1ccc2N([C@H](CC(=O)N3CC=CC3)CCc2c1)S(=O)(=O)c1ccc(F)cc1)(C(F)(F)F)C(F)(F)F InChI=1S/C24H21F7N2O4S/c25-17-5-8-19(9-6-17)38(36,37)33-18(14-21(34)32-11-1-2-12-32)7-3-15-13-16(4-10-20(15)33)22(35,23(26,27)28)24(29,30)31/h1-2,4-6,8-10,13,18,35H,3,7,11-12,14H2/t18-/m0/s1 PXJJYJIXHVTGSP-SFHVURJKSA-N 327498 Step A: (S)-1-(2,5-dihydro-1H-pyrrol-1-yl)-2-(1-((4-fluorophenyl)sulfonyl)-6-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,2,3,4-tetrahydroquinolin-2-yl)ethanone::US9663469, 38 Nuclear receptor ROR-gamma [262-507] 41.6 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327498 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327498&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117940698 384582442 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643552 CC(C)C(C)(NC(=O)C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F)C(N)=O InChI=1S/C26H28F7N3O5S/c1-14(2)23(3,22(34)38)35-21(37)13-18-8-4-15-12-16(24(39,25(28,29)30)26(31,32)33)5-11-20(15)36(18)42(40,41)19-9-6-17(27)7-10-19/h5-7,9-12,14,18,39H,4,8,13H2,1-3H3,(H2,34,38)(H,35,37)/t18-,23?/m0/s1 NQNUEQUYYUNMQK-XNUZUHMRSA-N 327499 US9663469, 39A Nuclear receptor ROR-gamma [262-507] 193 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327499 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327499&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117950163 384582443 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643553 CC(C)C(C)(NC(=O)C[C@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F)C(N)=O InChI=1S/C26H28F7N3O5S/c1-14(2)23(3,22(34)38)35-21(37)13-18-8-4-15-12-16(24(39,25(28,29)30)26(31,32)33)5-11-20(15)36(18)42(40,41)19-9-6-17(27)7-10-19/h5-7,9-12,14,18,39H,4,8,13H2,1-3H3,(H2,34,38)(H,35,37)/t18-,23?/m1/s1 NQNUEQUYYUNMQK-FKSKYRLFSA-N 327500 US9663469, 39B Nuclear receptor ROR-gamma [262-507] 149 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327500 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327500&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 138404124 384582444 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643554 CC1(CNC(=O)C[C@@H]2CCc3cc(ccc3N2S(=O)(=O)c2ccc(F)cc2)C(O)(C(F)(F)F)C(F)(F)F)NC(=O)N(CF)C1=O InChI=1S/C26H24F8N4O6S/c1-23(21(40)37(13-27)22(41)36-23)12-35-20(39)11-17-6-2-14-10-15(24(42,25(29,30)31)26(32,33)34)3-9-19(14)38(17)45(43,44)18-7-4-16(28)5-8-18/h3-5,7-10,17,42H,2,6,11-13H2,1H3,(H,35,39)(H,36,41)/t17-,23?/m0/s1 HSJNGIPODAMJQT-NVHKAFQKSA-N 327501 N-((1-(fluoromethyl)-4-methyl-2,5-dioxoimidazolidin-4-yl)methyl)-2-((S)-1-((4-fluorophenyl)sulfonyl)-6-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,2,3,4-tetrahydroquinolin-2-yl)acetamide::US9663469, 40 Nuclear receptor ROR-gamma [262-507] 52.3 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327501 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327501&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117940723 384582445 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643555 OCC1(O)CCN(C1)C(=O)C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C25H25F7N2O6S/c26-17-3-6-19(7-4-17)41(39,40)34-18(12-21(36)33-10-9-22(37,13-33)14-35)5-1-15-11-16(2-8-20(15)34)23(38,24(27,28)29)25(30,31)32/h2-4,6-8,11,18,35,37-38H,1,5,9-10,12-14H2/t18-,22?/m0/s1 PYUXVEQDFXRJEX-HXBUSHRASA-N 327502 2-((S)-1-((4-fluorophenyl)sulfonyl)-6-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,2,3,4-tetrahydroquinolin-2-yl)-1-(3-hydroxy-3-(hydroxymethyl)pyrrolidin-1-yl)ethanone::US9663469, 41 Nuclear receptor ROR-gamma [262-507] 23.7 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327502 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327502&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117941097 384582446 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643556 OC(c1ccc2N([C@H](CC(=O)N3C[C@H]4OC(=O)O[C@H]4C3)CCc2c1)S(=O)(=O)c1ccc(F)cc1)(C(F)(F)F)C(F)(F)F InChI=1S/C25H21F7N2O7S/c26-15-3-6-17(7-4-15)42(38,39)34-16(10-21(35)33-11-19-20(12-33)41-22(36)40-19)5-1-13-9-14(2-8-18(13)34)23(37,24(27,28)29)25(30,31)32/h2-4,6-9,16,19-20,37H,1,5,10-12H2/t16-,19-,20+/m0/s1 LUUWXUJAFYCKEM-FFZOFVMBSA-N 327503 US9663469, 42 Nuclear receptor ROR-gamma [262-507] 11.8 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327503 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327503&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117949993 384582447 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643557 CC(C)(O)CN1C(=O)NC(C)(CN(Cc2ccccc2)Cc2ccccc2)C1=O InChI=1S/C23H29N3O3/c1-22(2,29)16-26-20(27)23(3,24-21(26)28)17-25(14-18-10-6-4-7-11-18)15-19-12-8-5-9-13-19/h4-13,29H,14-17H2,1-3H3,(H,24,28) VIYUSGLIUUPALR-UHFFFAOYSA-N 327504 Step A: 5-((dibenzylamino)methyl)-3-(2-hydroxy-2-methylpropyl)-5-methylimidazolidine-2,4-dione::US9663469, 43 Nuclear receptor ROR-gamma [262-507] 20.6 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327504 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327504&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117940868 384582448 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643558 OC(c1ccc2N([C@H](CC(=O)NCC(=O)OCc3ccccc3)CCc2c1)S(=O)(=O)c1ccc(F)cc1)(C(F)(F)F)C(F)(F)F InChI=1S/C29H25F7N2O6S/c30-21-8-11-23(12-9-21)45(42,43)38-22(15-25(39)37-16-26(40)44-17-18-4-2-1-3-5-18)10-6-19-14-20(7-13-24(19)38)27(41,28(31,32)33)29(34,35)36/h1-5,7-9,11-14,22,41H,6,10,15-17H2,(H,37,39)/t22-/m0/s1 YHLULYRXCGFVGB-QFIPXVFZSA-N 327505 (S)-benzyl 2-(2-(1-((4-fluorophenyl)sulfonyl)-6-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,2,3,4-tetrahydroquinolin-2-yl)acetamido)acetate::US9663469, 44 Nuclear receptor ROR-gamma [262-507] 63.4 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327505 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327505&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117950136 384582449 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643559 OC(=O)CNC(=O)C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C22H19F7N2O6S/c23-14-3-6-16(7-4-14)38(36,37)31-15(10-18(32)30-11-19(33)34)5-1-12-9-13(2-8-17(12)31)20(35,21(24,25)26)22(27,28)29/h2-4,6-9,15,35H,1,5,10-11H2,(H,30,32)(H,33,34)/t15-/m0/s1 LEZVJLHMDYPHQY-HNNXBMFYSA-N 327506 (S)-2-(2-(1-((4-fluorophenyl)sulfonyl)-6-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,2,3,4-tetrahydroquinolin-2-yl)acetamido)acetic acid::US9663469, 45 Nuclear receptor ROR-gamma [262-507] 99.9 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327506 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327506&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117940843 384582450 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643560 OC(c1ccc2N([C@H](CC(=O)N[C@@H]3COC(=O)C3)CCc2c1)S(=O)(=O)c1ccc(F)cc1)(C(F)(F)F)C(F)(F)F InChI=1S/C24H21F7N2O6S/c25-15-3-6-18(7-4-15)40(37,38)33-17(11-20(34)32-16-10-21(35)39-12-16)5-1-13-9-14(2-8-19(13)33)22(36,23(26,27)28)24(29,30)31/h2-4,6-9,16-17,36H,1,5,10-12H2,(H,32,34)/t16-,17-/m0/s1 GRMNGHBHBPRMIK-IRXDYDNUSA-N 327507 2-((S)-1-((4-fluorophenyl)sulfonyl)-6-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,2,3,4-tetrahydroquinolin-2-yl)-N—((S)-5-oxotetrahydro furan-3-yl)acetamide::US9663469, 46 Nuclear receptor ROR-gamma [262-507] 19.2 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327507 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327507&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117940951 384582451 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643561 CC1(O)CCN(C1)C(=O)C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C25H25F7N2O5S/c1-22(36)10-11-33(14-22)21(35)13-18-6-2-15-12-16(23(37,24(27,28)29)25(30,31)32)3-9-20(15)34(18)40(38,39)19-7-4-17(26)5-8-19/h3-5,7-9,12,18,36-37H,2,6,10-11,13-14H2,1H3/t18-,22?/m0/s1 BMPNKLCPHIYLRR-HXBUSHRASA-N 327508 2-((S)-1-((4-fluorophenyl)sulfonyl)-6-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,2,3,4-tetrahydroquinolin-2-yl)-1-(3-hydroxy-3-methylpyrrolidin-1-yl)ethanone::US9663469, 47 Nuclear receptor ROR-gamma [262-507] 16.1 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327508 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327508&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117950141 384582452 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643562 OC1CN(C1)C(=O)CNC(=O)C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C25H24F7N3O6S/c26-16-3-6-19(7-4-16)42(40,41)35-17(10-21(37)33-11-22(38)34-12-18(36)13-34)5-1-14-9-15(2-8-20(14)35)23(39,24(27,28)29)25(30,31)32/h2-4,6-9,17-18,36,39H,1,5,10-13H2,(H,33,37)/t17-/m0/s1 HODWZBJHXZYQBH-KRWDZBQOSA-N 327509 (S)-2-(1-((4-fluorophenyl)sulfonyl)-6-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,2,3,4-tetrahydroquinolin-2-yl)-N-(2-(3-hydroxyazetidin-1-yl)-2-oxoethyl)acetamide::US9663469, 48 Nuclear receptor ROR-gamma [262-507] 47.0 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327509 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327509&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117949996 384582453 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643563 NCC1(O)CCN(C1)C(=O)C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C25H26F7N3O5S/c26-17-3-6-19(7-4-17)41(39,40)35-18(12-21(36)34-10-9-22(37,13-33)14-34)5-1-15-11-16(2-8-20(15)35)23(38,24(27,28)29)25(30,31)32/h2-4,6-8,11,18,37-38H,1,5,9-10,12-14,33H2/t18-,22?/m0/s1 UEOBVUINZXMETE-HXBUSHRASA-N 327510 1-(3-(aminomethyl)-3-hydroxypyrrolidin-1-yl)-2-((S)-1-((4-fluorophenyl)sulfonyl)-6-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,2,3,4-tetrahydroquinolin-2-yl)ethanone::US9663469, 49 Nuclear receptor ROR-gamma [262-507] 80.1 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327510 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327510&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117940794 384582454 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643564 OC1CN(C1)C(=O)C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C23H21F7N2O5S/c24-15-3-6-18(7-4-15)38(36,37)32-16(10-20(34)31-11-17(33)12-31)5-1-13-9-14(2-8-19(13)32)21(35,22(25,26)27)23(28,29)30/h2-4,6-9,16-17,33,35H,1,5,10-12H2/t16-/m0/s1 BLBDURVDDQPEOM-INIZCTEOSA-N 327511 (S)-2-(1-((4-fluorophenyl)sulfonyl)-6-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,2,3,4-tetrahydroquinolin-2-yl)-1-(3-hydroxyazetidin-1-yl)ethanone::US9663469, 50 Nuclear receptor ROR-gamma [262-507] 19.6 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327511 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327511&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117950151 384582455 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643565 OC(c1ccc2N([C@H](CC(=O)N3CCC4(CNC(=O)O4)C3)CCc2c1)S(=O)(=O)c1ccc(F)cc1)(C(F)(F)F)C(F)(F)F InChI=1S/C26H24F7N3O6S/c27-17-3-6-19(7-4-17)43(40,41)36-18(12-21(37)35-10-9-23(14-35)13-34-22(38)42-23)5-1-15-11-16(2-8-20(15)36)24(39,25(28,29)30)26(31,32)33/h2-4,6-8,11,18,39H,1,5,9-10,12-14H2,(H,34,38)/t18-,23?/m0/s1 YJKJFKSXIHIWSQ-XNUZUHMRSA-N 327512 7-(2-((S)-1-((4-fluorophenyl)sulfonyl)-6-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,2,3,4-tetrahydroquinolin-2-yl)acetyl)-1-oxa-3,7-diazaspiro[4.4]nonan-2-one::US9663469, 51 Nuclear receptor ROR-gamma [262-507] 23.2 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327512 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327512&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117940790 384582456 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643566 OC(c1ccc2N([C@H](CC(=O)NCc3nnn[nH]3)CCc2c1)S(=O)(=O)c1ccc(F)cc1)(C(F)(F)F)C(F)(F)F 327513 (S)—N-((1H-tetrazol-5-yl)methyl)-2-(1-((4-fluorophenyl)sulfonyl)-6-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,2,3,4-tetrahydroquinolin-2-yl)acetamide::US9663469, 52 Nuclear receptor ROR-gamma [262-507] 49.9 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327513 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327513&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117940629 384582457 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643567 OC(c1ccc2N([C@H](CC(=O)N3CCC(C3)NC(=O)c3ccccc3)CCc2c1)S(=O)(=O)c1ccc(F)cc1)(C(F)(F)F)C(F)(F)F InChI=1S/C31H28F7N3O5S/c32-22-8-11-25(12-9-22)47(45,46)41-24(17-27(42)40-15-14-23(18-40)39-28(43)19-4-2-1-3-5-19)10-6-20-16-21(7-13-26(20)41)29(44,30(33,34)35)31(36,37)38/h1-5,7-9,11-13,16,23-24,44H,6,10,14-15,17-18H2,(H,39,43)/t23?,24-/m0/s1 NULKBXRLIDQIMK-CGAIIQECSA-N 327514 N-(1-(2-((S)-1-((4-fluorophenyl)sulfonyl)-6-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,2,3,4-tetrahydroquinolin-2-yl)acetyl)pyrrolidin-3-yl)benzamide::US9663469, 53 Nuclear receptor ROR-gamma [262-507] 43.0 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327514 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327514&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117949999 384582458 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643568 CCNC(=O)NCC1(O)CCN(C1)C(=O)C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C28H31F7N4O6S/c1-2-36-24(41)37-15-25(42)11-12-38(16-25)23(40)14-20-7-3-17-13-18(26(43,27(30,31)32)28(33,34)35)4-10-22(17)39(20)46(44,45)21-8-5-19(29)6-9-21/h4-6,8-10,13,20,42-43H,2-3,7,11-12,14-16H2,1H3,(H2,36,37,41)/t20-,25?/m0/s1 AKBCMGCVEIKBIP-JINQPTGOSA-N 327515 1-ethyl-3-((1-(2-((S)-1-((4-fluorophenyl)sulfonyl)-6-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,2,3,4-tetrahydroquinolin-2-yl)acetyl)-3-hydroxypyrrolidin-3-yl)methyl)urea::US9663469, 54 Nuclear receptor ROR-gamma [262-507] 75.2 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327515 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327515&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117941082 384582459 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643569 CCOC(=O)NCC1(O)CCN(C1)C(=O)C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C28H30F7N3O7S/c1-2-45-24(40)36-15-25(41)11-12-37(16-25)23(39)14-20-7-3-17-13-18(26(42,27(30,31)32)28(33,34)35)4-10-22(17)38(20)46(43,44)21-8-5-19(29)6-9-21/h4-6,8-10,13,20,41-42H,2-3,7,11-12,14-16H2,1H3,(H,36,40)/t20-,25?/m0/s1 JHQYYGNFJUSGAW-JINQPTGOSA-N 327516 Ethyl ((1-(2-((S)-1-((4-fluorophenyl)sulfonyl)-6-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,2,3,4-tetrahydroquinolin-2-yl)acetyl)-3-hydroxypyrrolidin-3-yl)methyl)carbamate::US9663469, 55 Nuclear receptor ROR-gamma [262-507] 42.8 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327516 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327516&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117950152 384582460 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643570 OC(c1ccc2N([C@H](CC(=O)N3CCC4(COC(=O)O4)C3)CCc2c1)S(=O)(=O)c1ccc(F)cc1)(C(F)(F)F)C(F)(F)F InChI=1S/C26H23F7N2O7S/c27-17-3-6-19(7-4-17)43(39,40)35-18(12-21(36)34-10-9-23(13-34)14-41-22(37)42-23)5-1-15-11-16(2-8-20(15)35)24(38,25(28,29)30)26(31,32)33/h2-4,6-8,11,18,38H,1,5,9-10,12-14H2/t18-,23?/m0/s1 WXZKJRHAYLCPEV-XNUZUHMRSA-N 327517 7-(2-((S)-1-((4-fluorophenyl)sulfonyl)-6-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,2,3,4-tetrahydroquinolin-2-yl)acetyl)-1,3-dioxa-7-azaspiro[4.4]nonan-2-one::US9663469, 56 Nuclear receptor ROR-gamma [262-507] 28.5 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327517 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327517&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117940556 384582461 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643571 CCN1C(=O)NC(C)(CNC(=O)C[C@@H]2CCc3cc(ccc3N2S(=O)(=O)c2ccc(F)cc2)C(O)(C(F)(F)F)C(F)(F)F)C1=O InChI=1S/C27H27F7N4O6S/c1-3-37-22(40)24(2,36-23(37)41)14-35-21(39)13-18-8-4-15-12-16(25(42,26(29,30)31)27(32,33)34)5-11-20(15)38(18)45(43,44)19-9-6-17(28)7-10-19/h5-7,9-12,18,42H,3-4,8,13-14H2,1-2H3,(H,35,39)(H,36,41)/t18-,24?/m0/s1 WLKPHMUGPVKIME-VEXWJQHLSA-N 327518 N-((1-ethyl-4-methyl-2,5-dioxoimidazolidin-4-yl)methyl)-2-((S)-1-((4-fluorophenyl)sulfonyl)-6-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,2,3,4-tetrahydroquinolin-2-yl)acetamide::US9663469, 57 Nuclear receptor ROR-gamma [262-507] 25.2 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327518 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327518&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117940683 384582462 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643572 NC(=O)[C@@H]1CCC[C@@H]1NC(=O)C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C26H26F7N3O5S/c27-16-6-9-18(10-7-16)42(40,41)36-17(13-22(37)35-20-3-1-2-19(20)23(34)38)8-4-14-12-15(5-11-21(14)36)24(39,25(28,29)30)26(31,32)33/h5-7,9-12,17,19-20,39H,1-4,8,13H2,(H2,34,38)(H,35,37)/t17-,19+,20-/m0/s1 ZOMDOJSYEAJNFT-SXLOBPIMSA-N 327519 Cis-2-(2-((S)-1-((4-fluorophenyl)sulfonyl)-6-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,2,3,4-tetrahydroquinolin-2-yl)acetamido)cyclopentanecarboxamide::US9663469, 58 Nuclear receptor ROR-gamma [262-507] 41.2 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327519 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327519&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117940746 384582463 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643573 NC(=O)C1CCN(C1)C(=O)C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C25H24F7N3O5S/c26-17-3-6-19(7-4-17)41(39,40)35-18(12-21(36)34-10-9-15(13-34)22(33)37)5-1-14-11-16(2-8-20(14)35)23(38,24(27,28)29)25(30,31)32/h2-4,6-8,11,15,18,38H,1,5,9-10,12-13H2,(H2,33,37)/t15?,18-/m0/s1 CMKSWKCBVAVDPK-PKHIMPSTSA-N 327520 1-(2-((S)-1-((4-fluorophenyl)sulfonyl)-6-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,2,3,4-tetrahydroquinolin-2-yl)acetyl)pyrrolidine-3-carboxamide::US9663469, 59 Nuclear receptor ROR-gamma [262-507] 46.7 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327520 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327520&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117950118 384582464 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643574 OC(c1ccc2N([C@H](CC(=O)NC3COC3=O)CCc2c1)S(=O)(=O)c1ccc(F)cc1)(C(F)(F)F)C(F)(F)F InChI=1S/C23H19F7N2O6S/c24-14-3-6-16(7-4-14)39(36,37)32-15(10-19(33)31-17-11-38-20(17)34)5-1-12-9-13(2-8-18(12)32)21(35,22(25,26)27)23(28,29)30/h2-4,6-9,15,17,35H,1,5,10-11H2,(H,31,33)/t15-,17?/m0/s1 CPYVBRBSDRGMBK-MYJWUSKBSA-N 327521 2-((S)-1-((4-fluorophenyl)sulfonyl)-6-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,2,3,4-tetrahydroquinolin-2-yl)-N-(2-oxooxetan-3-yl)acetamide::US9663469, 60 Nuclear receptor ROR-gamma [262-507] 588 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327521 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327521&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117950187 384582465 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643575 OCC1(O)CCN(C1)C(=O)CNC(=O)C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C27H28F7N3O7S/c28-18-3-6-20(7-4-18)45(43,44)37-19(12-22(39)35-13-23(40)36-10-9-24(41,14-36)15-38)5-1-16-11-17(2-8-21(16)37)25(42,26(29,30)31)27(32,33)34/h2-4,6-8,11,19,38,41-42H,1,5,9-10,12-15H2,(H,35,39)/t19-,24?/m0/s1 ICHMHWHFLQKJPG-XGLRFROISA-N 327522 2-((S)-1-((4-fluorophenyl)sulfonyl)-6-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,2,3,4-tetrahydroquinolin-2-yl)-N-(2-(3-hydroxy-3-(hydroxymethyl)pyrrolidin-1-yl)-2-oxoethyl)acetamide::US9663469, 61 Nuclear receptor ROR-gamma [262-507] 33.3 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327522 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327522&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117941076 384582466 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643576 OCc1ccccc1NC(=O)C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C27H23F7N2O5S/c28-19-7-10-21(11-8-19)42(40,41)36-20(14-24(38)35-22-4-2-1-3-17(22)15-37)9-5-16-13-18(6-12-23(16)36)25(39,26(29,30)31)27(32,33)34/h1-4,6-8,10-13,20,37,39H,5,9,14-15H2,(H,35,38)/t20-/m0/s1 FZAMVHVCXHOKJK-FQEVSTJZSA-N 327523 (S)-2-(1-((4-fluorophenyl)sulfonyl)-6-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,2,3,4-tetrahydroquinolin-2-yl)-N-(2-(hydroxymethyl)phenyl)acetamide::US9663469, 62 Nuclear receptor ROR-gamma [262-507] 10.1 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327523 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327523&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117940647 384582467 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643577 O[C@H]1CC[C@@H](CC1)NC(=O)CNC(=O)C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C28H30F7N3O6S/c29-18-3-10-22(11-4-18)45(43,44)38-20(14-24(40)36-15-25(41)37-19-5-8-21(39)9-6-19)7-1-16-13-17(2-12-23(16)38)26(42,27(30,31)32)28(33,34)35/h2-4,10-13,19-21,39,42H,1,5-9,14-15H2,(H,36,40)(H,37,41)/t19-,20-,21-/m0/s1 BLWKQLOJUXKTGZ-ACRUOGEOSA-N 327524 2-((S)-1-((4-fluorophenyl)sulfonyl)-6-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,2,3,4-tetrahydroquinolin-2-yl)-N-(2-((trans-4-hydroxycyclohexyl)amino)-2-oxoethyl)acetamide::US9663469, 63 Nuclear receptor ROR-gamma [262-507] 12.2 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327524 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327524&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117940636 384582468 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643578 NC(=O)[C@H]1CCCN1C(=O)C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C25H24F7N3O5S/c26-16-5-8-18(9-6-16)41(39,40)35-17(13-21(36)34-11-1-2-20(34)22(33)37)7-3-14-12-15(4-10-19(14)35)23(38,24(27,28)29)25(30,31)32/h4-6,8-10,12,17,20,38H,1-3,7,11,13H2,(H2,33,37)/t17-,20+/m0/s1 GSZQEKORIJSYSX-FXAWDEMLSA-N 327525 (R)-1-(2-((S)-1-((4-fluorophenyl)sulfonyl)-6-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,2,3,4-tetrahydroquinolin-2-yl)acetyl)pyrrolidine-2-carboxamide::US9663469, 64 Nuclear receptor ROR-gamma [262-507] 23.7 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327525 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327525&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117950001 384582469 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643579 NC(=O)[C@@H]1CCCN1C(=O)C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C25H24F7N3O5S/c26-16-5-8-18(9-6-16)41(39,40)35-17(13-21(36)34-11-1-2-20(34)22(33)37)7-3-14-12-15(4-10-19(14)35)23(38,24(27,28)29)25(30,31)32/h4-6,8-10,12,17,20,38H,1-3,7,11,13H2,(H2,33,37)/t17-,20-/m0/s1 GSZQEKORIJSYSX-PXNSSMCTSA-N 327526 (S)-1-(2-((S)-1-((4-fluorophenyl)sulfonyl)-6-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,2,3,4-tetrahydroquinolin-2-yl)acetyl)pyrrolidine-2-carboxamide::US9663469, 65 Nuclear receptor ROR-gamma [262-507] 21.6 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327526 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327526&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117950091 384582470 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643580 CN(C)[C@H]1CN(C[C@@H]1O)C(=O)C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C26H28F7N3O5S/c1-34(2)21-13-35(14-22(21)37)23(38)12-18-7-3-15-11-16(24(39,25(28,29)30)26(31,32)33)4-10-20(15)36(18)42(40,41)19-8-5-17(27)6-9-19/h4-6,8-11,18,21-22,37,39H,3,7,12-14H2,1-2H3/t18-,21-,22-/m0/s1 NAGJTDGXUVVWJO-NYVOZVTQSA-N 327527 US9663469, 66::trans-3-(dimethylamino)-4-hydroxypyrrolidin-1-yl)-2-((S)-1-((4-fluorophenyl)sulfonyl)-6-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,2,3,4-tetrahydroquinolin-2-yl)ethanone Nuclear receptor ROR-gamma [262-507] 39.8 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327527 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327527&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117950000 384582471 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643581 OCC1[C@@H](O)[C@@H](O)CN1C(=O)C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C25H25F7N2O7S/c26-15-3-6-17(7-4-15)42(40,41)34-16(10-21(37)33-11-20(36)22(38)19(33)12-35)5-1-13-9-14(2-8-18(13)34)23(39,24(27,28)29)25(30,31)32/h2-4,6-9,16,19-20,22,35-36,38-39H,1,5,10-12H2/t16-,19?,20-,22+/m0/s1 OSZKXYVXALGRHQ-DKFAITCISA-N 327528 1-(cis-3,4-dihydroxy-2-(hydroxymethyl)pyrrolidin-1-yl)-2-((S)-1-((4-fluorophenyl)sulfonyl)-6-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,2,3,4-tetrahydroquinolin-2-yl)ethanone::US9663469, 67 Nuclear receptor ROR-gamma [262-507] 52.1 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327528 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327528&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117950154 384582472 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643582 OC(c1ccc2N([C@H](CC(=O)NC3CCOC3=O)CCc2c1)S(=O)(=O)c1ccc(F)cc1)(C(F)(F)F)C(F)(F)F InChI=1S/C24H21F7N2O6S/c25-15-3-6-17(7-4-15)40(37,38)33-16(12-20(34)32-18-9-10-39-21(18)35)5-1-13-11-14(2-8-19(13)33)22(36,23(26,27)28)24(29,30)31/h2-4,6-8,11,16,18,36H,1,5,9-10,12H2,(H,32,34)/t16-,18?/m0/s1 HZRLMXSPKXYGBH-ATNAJCNCSA-N 327529 2-((S)-1-((4-fluorophenyl)sulfonyl)-6-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,2,3,4-tetrahydroquinolin-2-yl)-N-(2-oxotetrahydrofuran-3-yl)acetamide::US9663469, 68 Nuclear receptor ROR-gamma [262-507] 45.5 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327529 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327529&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117940849 384582473 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643583 OC(c1ccc2N([C@H](CC(=O)NCC(=O)N[C@@H]3COC(=O)C3)CCc2c1)S(=O)(=O)c1ccc(F)cc1)(C(F)(F)F)C(F)(F)F InChI=1S/C26H24F7N3O7S/c27-16-3-6-19(7-4-16)44(41,42)36-18(11-21(37)34-12-22(38)35-17-10-23(39)43-13-17)5-1-14-9-15(2-8-20(14)36)24(40,25(28,29)30)26(31,32)33/h2-4,6-9,17-18,40H,1,5,10-13H2,(H,34,37)(H,35,38)/t17-,18-/m0/s1 VAOGJOSWJFCIMN-ROUUACIJSA-N 327530 2-((S)-1-((4-fluorophenyl)sulfonyl)-6-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,2,3,4-tetrahydroquinolin-2-yl)-N-(2-oxo-2-(((S)-5-oxotetrahydrofuran-3-yl)amino)ethyl)acetamide::US9663469, 69 Nuclear receptor ROR-gamma [262-507] 51.0 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327530 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327530&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117940979 384582474 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643584 NC(=O)[C@H]1C2CCC(O2)[C@H]1NC(=O)C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C27H26F7N3O6S/c28-15-3-6-17(7-4-15)44(41,42)37-16(12-21(38)36-23-20-10-9-19(43-20)22(23)24(35)39)5-1-13-11-14(2-8-18(13)37)25(40,26(29,30)31)27(32,33)34/h2-4,6-8,11,16,19-20,22-23,40H,1,5,9-10,12H2,(H2,35,39)(H,36,38)/t16-,19?,20?,22-,23+/m0/s1 XNQZKOBAKYMIEM-MXNRAWRZSA-N 327531 Exo-3-(2-((S)-1-((4-fluorophenyl)sulfonyl)-6-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,2,3,4-tetrahydroquinolin-2-yl)acetamido)-7-oxabicyclo[2.2.1]heptane-2-carboxamide::US9663469, 70 Nuclear receptor ROR-gamma [262-507] 58.1 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327531 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327531&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117950153 384582475 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643585 CC(C)(O)CNC(=O)CC1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C24H25F7N2O5S/c1-21(2,35)13-32-20(34)12-17-7-3-14-11-15(22(36,23(26,27)28)24(29,30)31)4-10-19(14)33(17)39(37,38)18-8-5-16(25)6-9-18/h4-6,8-11,17,35-36H,3,7,12-13H2,1-2H3,(H,32,34) WKDNXLPZDBZVOG-UHFFFAOYSA-N 327532 (�) 2-(1-((4-fluorophenyl)sulfonyl)-6-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,2,3,4-tetrahydroquinolin-2-yl)-N-(2-hydroxy-2-methylpropyl)acetamide::US9663469, 71 Nuclear receptor ROR-gamma [262-507] 46.0 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327532 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327532&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117940657 384582476 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643586 OC1CCN(CC1)C(=O)CC1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C25H25F7N2O5S/c26-17-3-6-20(7-4-17)40(38,39)34-18(14-22(36)33-11-9-19(35)10-12-33)5-1-15-13-16(2-8-21(15)34)23(37,24(27,28)29)25(30,31)32/h2-4,6-8,13,18-19,35,37H,1,5,9-12,14H2 VBIGJSRWMKNQGL-UHFFFAOYSA-N 327533 US9663469, 72 Nuclear receptor ROR-gamma [262-507] 35.8 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327533 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327533&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117950158 384582477 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643587 OC(c1ccc2N(C(CC(=O)N3CCNC(=O)C3)CCc2c1)S(=O)(=O)c1ccc(F)cc1)(C(F)(F)F)C(F)(F)F InChI=1S/C24H22F7N3O5S/c25-16-3-6-18(7-4-16)40(38,39)34-17(12-21(36)33-10-9-32-20(35)13-33)5-1-14-11-15(2-8-19(14)34)22(37,23(26,27)28)24(29,30)31/h2-4,6-8,11,17,37H,1,5,9-10,12-13H2,(H,32,35) GOYGXUBMHNNAHN-UHFFFAOYSA-N 327534 US9663469, 73 Nuclear receptor ROR-gamma [262-507] 45.4 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327534 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327534&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117940847 384582478 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643588 O[C@H]1CC[C@@H](CC1)NC(=O)CC1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C26H27F7N2O5S/c27-17-3-10-21(11-4-17)41(39,40)35-19(14-23(37)34-18-5-8-20(36)9-6-18)7-1-15-13-16(2-12-22(15)35)24(38,25(28,29)30)26(31,32)33/h2-4,10-13,18-20,36,38H,1,5-9,14H2,(H,34,37)/t18-,19?,20- GCPFGEWBHXJOOI-UQTQIZBZSA-N 327535 US9663469, 74 Nuclear receptor ROR-gamma [262-507] 40.8 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327535 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327535&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117950156 384582479 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643589 OCCNC(=O)CC1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C22H21F7N2O5S/c23-15-3-6-17(7-4-15)37(35,36)31-16(12-19(33)30-9-10-32)5-1-13-11-14(2-8-18(13)31)20(34,21(24,25)26)22(27,28)29/h2-4,6-8,11,16,32,34H,1,5,9-10,12H2,(H,30,33) QSFCOBZABPBZRM-UHFFFAOYSA-N 327536 US9663469, 75 Nuclear receptor ROR-gamma [262-507] 36.1 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327536 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327536&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117950166 384582480 C04080 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643590 C[C@](O)(CO)CNC(=O)C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C24H25F7N2O6S/c1-21(36,13-34)12-32-20(35)11-17-6-2-14-10-15(22(37,23(26,27)28)24(29,30)31)3-9-19(14)33(17)40(38,39)18-7-4-16(25)5-8-18/h3-5,7-10,17,34,36-37H,2,6,11-13H2,1H3,(H,32,35)/t17-,21+/m0/s1 RLUPBJVKCABYOH-LAUBAEHRSA-N 327537 US9663469, 76 Nuclear receptor ROR-gamma [262-507] 23.0 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327537 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327537&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117950183 384582481 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643591 C[C@@](O)(CO)CNC(=O)C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C24H25F7N2O6S/c1-21(36,13-34)12-32-20(35)11-17-6-2-14-10-15(22(37,23(26,27)28)24(29,30)31)3-9-19(14)33(17)40(38,39)18-7-4-16(25)5-8-18/h3-5,7-10,17,34,36-37H,2,6,11-13H2,1H3,(H,32,35)/t17-,21-/m0/s1 RLUPBJVKCABYOH-UWJYYQICSA-N 327538 US9663469, 77 Nuclear receptor ROR-gamma [262-507] 49.0 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327538 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327538&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117950171 384582482 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643592 OCCCNC(=O)CC1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C23H23F7N2O5S/c24-16-4-7-18(8-5-16)38(36,37)32-17(13-20(34)31-10-1-11-33)6-2-14-12-15(3-9-19(14)32)21(35,22(25,26)27)23(28,29)30/h3-5,7-9,12,17,33,35H,1-2,6,10-11,13H2,(H,31,34) NISRTHDBZHZJQA-UHFFFAOYSA-N 327539 US9663469, 78 Nuclear receptor ROR-gamma [262-507] 37.3 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327539 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327539&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117950193 384582483 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643593 CO[C@H]1CN(C[C@@H]1O)C(=O)C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C25H25F7N2O6S/c1-40-21-13-33(12-20(21)35)22(36)11-17-6-2-14-10-15(23(37,24(27,28)29)25(30,31)32)3-9-19(14)34(17)41(38,39)18-7-4-16(26)5-8-18/h3-5,7-10,17,20-21,35,37H,2,6,11-13H2,1H3/t17-,20-,21-/m0/s1 DAPDDIPXYUECRW-YYWHXJBOSA-N 327540 US9663469, 79 Nuclear receptor ROR-gamma [262-507] 137 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327540 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327540&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122660483 384582484 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643594 CCOC(=O)[C@H]1C2CCC(C2)[C@H]1NC(=O)C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C30H31F7N2O6S/c1-2-45-27(41)25-17-3-4-18(13-17)26(25)38-24(40)15-21-9-5-16-14-19(28(42,29(32,33)34)30(35,36)37)6-12-23(16)39(21)46(43,44)22-10-7-20(31)8-11-22/h6-8,10-12,14,17-18,21,25-26,42H,2-5,9,13,15H2,1H3,(H,38,40)/t17?,18?,21-,25-,26+/m0/s1 SQKXNPLIUBXKNY-HDXZOOEYSA-N 327541 US9663469, 80 Nuclear receptor ROR-gamma [262-507] 21.3 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327541 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327541&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122662338 384582485 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643595 CC(C)(C)OC(=O)N1CC[C@@H](NC(=O)C[C@@H]2CCc3cc(ccc3N2S(=O)(=O)c2ccc(F)cc2)C(O)(C(F)(F)F)C(F)(F)F)[C@H](CO)C1 InChI=1S/C31H36F7N3O7S/c1-28(2,3)48-27(44)40-13-12-24(19(16-40)17-42)39-26(43)15-22-8-4-18-14-20(29(45,30(33,34)35)31(36,37)38)5-11-25(18)41(22)49(46,47)23-9-6-21(32)7-10-23/h5-7,9-11,14,19,22,24,42,45H,4,8,12-13,15-17H2,1-3H3,(H,39,43)/t19-,22-,24+/m0/s1 QYIYSFVLACHXHW-NGYIFUPDSA-N 327542 US9663469, 81 Nuclear receptor ROR-gamma [262-507] 52.8 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327542 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327542&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122662337 384582486 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643596 CC(C)(C)OC(=O)N1C[C@@H](NC(=O)C[C@@H]2CCc3cc(ccc3N2S(=O)(=O)c2ccc(F)cc2)C(O)(C(F)(F)F)C(F)(F)F)[C@@H](C1)C(O)=O InChI=1S/C30H32F7N3O8S/c1-27(2,3)48-26(44)39-14-21(25(42)43)22(15-39)38-24(41)13-19-8-4-16-12-17(28(45,29(32,33)34)30(35,36)37)5-11-23(16)40(19)49(46,47)20-9-6-18(31)7-10-20/h5-7,9-12,19,21-22,45H,4,8,13-15H2,1-3H3,(H,38,41)(H,42,43)/t19-,21+,22+/m0/s1 LNJPLIYVRXXFCI-KSEOMHKRSA-N 327543 US9663469, 82 Nuclear receptor ROR-gamma [262-507] 288 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327543 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327543&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122662359 384582487 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643597 O[C@@H]1CN(C[C@H]1O)C(=O)C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C24H23F7N2O6S/c25-15-3-6-17(7-4-15)40(38,39)33-16(10-21(36)32-11-19(34)20(35)12-32)5-1-13-9-14(2-8-18(13)33)22(37,23(26,27)28)24(29,30)31/h2-4,6-9,16,19-20,34-35,37H,1,5,10-12H2/t16-,19+,20+/m0/s1 ZQHJNPLTLLUIIB-PWIZWCRZSA-N 327544 US9663469, 83 Nuclear receptor ROR-gamma [262-507] 43.8 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327544 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327544&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122660494 384582488 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643598 CC(C)(C)OC(=O)N1C[C@@H](CO)[C@@H](C1)NC(=O)C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C30H34F7N3O7S/c1-27(2,3)47-26(43)39-14-18(16-41)23(15-39)38-25(42)13-21-8-4-17-12-19(28(44,29(32,33)34)30(35,36)37)5-11-24(17)40(21)48(45,46)22-9-6-20(31)7-10-22/h5-7,9-12,18,21,23,41,44H,4,8,13-16H2,1-3H3,(H,38,42)/t18-,21-,23+/m0/s1 HZKAYWPYYAWNLG-AVCGJXAMSA-N 327545 US9663469, 84 Nuclear receptor ROR-gamma [262-507] 69.8 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327545 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327545&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122662270 384582489 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643599 COc1cccc(c1)N1CC(CC1=O)NC(=O)C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C31H28F7N3O6S/c1-47-24-4-2-3-22(15-24)40-17-21(14-28(40)43)39-27(42)16-23-9-5-18-13-19(29(44,30(33,34)35)31(36,37)38)6-12-26(18)41(23)48(45,46)25-10-7-20(32)8-11-25/h2-4,6-8,10-13,15,21,23,44H,5,9,14,16-17H2,1H3,(H,39,42)/t21?,23-/m0/s1 CXGXXYPSSOYMQL-YANBTOMASA-N 327546 US9663469, 85::US9663469, 89 Nuclear receptor ROR-gamma [262-507] 306 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327546 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327546&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122662308 384582490 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643600 CCCN1CC(CC1=O)NC(=O)C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C27H28F7N3O5S/c1-2-11-36-15-19(13-24(36)39)35-23(38)14-20-7-3-16-12-17(25(40,26(29,30)31)27(32,33)34)4-10-22(16)37(20)43(41,42)21-8-5-18(28)6-9-21/h4-6,8-10,12,19-20,40H,2-3,7,11,13-15H2,1H3,(H,35,38)/t19?,20-/m0/s1 APJCWTPVRXODMI-ANYOKISRSA-N 327547 US9663469, 86 Nuclear receptor ROR-gamma [262-507] 10.8 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327547 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327547&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122662376 384582491 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643601 CC(C)(O)CCNC(=O)C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C25H27F7N2O5S/c1-22(2,36)11-12-33-21(35)14-18-7-3-15-13-16(23(37,24(27,28)29)25(30,31)32)4-10-20(15)34(18)40(38,39)19-8-5-17(26)6-9-19/h4-6,8-10,13,18,36-37H,3,7,11-12,14H2,1-2H3,(H,33,35)/t18-/m0/s1 YAKOZLMOVOSZNF-SFHVURJKSA-N 327548 US9663469, 87 Nuclear receptor ROR-gamma [262-507] 24.4 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327548 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327548&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122662273 384582492 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643602 OC(c1ccc2N([C@H](CC(=O)NC3CCCCC3)CCc2c1)S(=O)(=O)c1ccc(F)cc1)(C(F)(F)F)C(F)(F)F InChI=1S/C26H27F7N2O4S/c27-18-8-11-21(12-9-18)40(38,39)35-20(15-23(36)34-19-4-2-1-3-5-19)10-6-16-14-17(7-13-22(16)35)24(37,25(28,29)30)26(31,32)33/h7-9,11-14,19-20,37H,1-6,10,15H2,(H,34,36)/t20-/m0/s1 XDFIRZBZAOBUNZ-FQEVSTJZSA-N 327549 US9663469, 88 Nuclear receptor ROR-gamma [262-507] 25.5 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327549 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327549&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122662340 384582493 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643603 COc1cccc(c1)N1CC(CC1=O)NC(=O)C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C31H28F7N3O6S/c1-47-24-4-2-3-22(15-24)40-17-21(14-28(40)43)39-27(42)16-23-9-5-18-13-19(29(44,30(33,34)35)31(36,37)38)6-12-26(18)41(23)48(45,46)25-10-7-20(32)8-11-25/h2-4,6-8,10-13,15,21,23,44H,5,9,14,16-17H2,1H3,(H,39,42)/t21?,23-/m0/s1 CXGXXYPSSOYMQL-YANBTOMASA-N 327546 US9663469, 85::US9663469, 89 Nuclear receptor ROR-gamma [262-507] 66.6 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327546 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327546&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122662308 384582490 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643604 OC[C@@H]1CNC[C@H]1NC(=O)C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C25H26F7N3O5S/c26-17-3-6-19(7-4-17)41(39,40)35-18(10-22(37)34-20-12-33-11-15(20)13-36)5-1-14-9-16(2-8-21(14)35)23(38,24(27,28)29)25(30,31)32/h2-4,6-9,15,18,20,33,36,38H,1,5,10-13H2,(H,34,37)/t15-,18-,20+/m0/s1 VXIXVGMGRZLDFG-ZAAXVRCTSA-N 327551 US9663469, 90 Nuclear receptor ROR-gamma [262-507] 110 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327551 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327551&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122662313 384582494 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643605 CC(=O)N1C[C@@H](CO)[C@@H](C1)NC(=O)C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C27H28F7N3O6S/c1-15(39)36-12-17(14-38)22(13-36)35-24(40)11-20-6-2-16-10-18(25(41,26(29,30)31)27(32,33)34)3-9-23(16)37(20)44(42,43)21-7-4-19(28)5-8-21/h3-5,7-10,17,20,22,38,41H,2,6,11-14H2,1H3,(H,35,40)/t17-,20-,22+/m0/s1 DVFZICGMTNTAAX-RBDMOPTHSA-N 327552 US9663469, 91 Nuclear receptor ROR-gamma [262-507] 19.6 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327552 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327552&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122662288 384582495 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643606 OC(c1ccc2N([C@H](CC(=O)N[C@H]3COC(=O)C3)CCc2c1)S(=O)(=O)c1ccc(F)cc1)(C(F)(F)F)C(F)(F)F InChI=1S/C24H21F7N2O6S/c25-15-3-6-18(7-4-15)40(37,38)33-17(11-20(34)32-16-10-21(35)39-12-16)5-1-13-9-14(2-8-19(13)33)22(36,23(26,27)28)24(29,30)31/h2-4,6-9,16-17,36H,1,5,10-12H2,(H,32,34)/t16-,17+/m1/s1 GRMNGHBHBPRMIK-SJORKVTESA-N 327553 US9663469, 92 Nuclear receptor ROR-gamma [262-507] 20.2 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327553 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327553&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122662342 384582496 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643607 OCc1cnccc1NC(=O)C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C26H22F7N3O5S/c27-18-3-6-20(7-4-18)42(40,41)36-19(12-23(38)35-21-9-10-34-13-16(21)14-37)5-1-15-11-17(2-8-22(15)36)24(39,25(28,29)30)26(31,32)33/h2-4,6-11,13,19,37,39H,1,5,12,14H2,(H,34,35,38)/t19-/m0/s1 YFOVQQKCVZVGGS-IBGZPJMESA-N 327554 US9663469, 93 Nuclear receptor ROR-gamma [262-507] 68.8 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327554 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327554&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122662377 384582497 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643608 OC(c1ccc2N([C@H](CC(=O)NC3CCOC3)CCc2c1)S(=O)(=O)c1ccc(F)cc1)(C(F)(F)F)C(F)(F)F InChI=1S/C24H23F7N2O5S/c25-16-3-6-19(7-4-16)39(36,37)33-18(12-21(34)32-17-9-10-38-13-17)5-1-14-11-15(2-8-20(14)33)22(35,23(26,27)28)24(29,30)31/h2-4,6-8,11,17-18,35H,1,5,9-10,12-13H2,(H,32,34)/t17?,18-/m0/s1 SPKUZABTFOYFJV-ZVAWYAOSSA-N 327555 BMT-095613::US9663469, 94 Nuclear receptor ROR-gamma [262-507] 17.1 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327555 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327555&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122662290 384582498 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643609 OC(c1ccc2N([C@H](CC(=O)NC3CCOCC3)CCc2c1)S(=O)(=O)c1ccc(F)cc1)(C(F)(F)F)C(F)(F)F InChI=1S/C25H25F7N2O5S/c26-17-3-6-20(7-4-17)40(37,38)34-19(14-22(35)33-18-9-11-39-12-10-18)5-1-15-13-16(2-8-21(15)34)23(36,24(27,28)29)25(30,31)32/h2-4,6-8,13,18-19,36H,1,5,9-12,14H2,(H,33,35)/t19-/m0/s1 ZKBTVZJXZIPAEW-IBGZPJMESA-N 327556 US9663469, 95 Nuclear receptor ROR-gamma [262-507] 14.8 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327556 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327556&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122662272 384582499 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643610 OC(c1ccc2N([C@H](CC(=O)NC3CCNC(=O)C3)CCc2c1)S(=O)(=O)c1ccc(F)cc1)(C(F)(F)F)C(F)(F)F InChI=1S/C25H24F7N3O5S/c26-16-3-6-19(7-4-16)41(39,40)35-18(13-22(37)34-17-9-10-33-21(36)12-17)5-1-14-11-15(2-8-20(14)35)23(38,24(27,28)29)25(30,31)32/h2-4,6-8,11,17-18,38H,1,5,9-10,12-13H2,(H,33,36)(H,34,37)/t17?,18-/m0/s1 RUZAMBMUTVNACU-ZVAWYAOSSA-N 327557 US9663469, 96 Nuclear receptor ROR-gamma [262-507] 48.4 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327557 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327557&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122662289 384582500 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643611 OC[C@H]1C2CCC(C2)[C@H]1NC(=O)C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C28H29F7N2O5S/c29-19-5-8-21(9-6-19)43(41,42)37-20(13-24(39)36-25-17-2-1-15(11-17)22(25)14-38)7-3-16-12-18(4-10-23(16)37)26(40,27(30,31)32)28(33,34)35/h4-6,8-10,12,15,17,20,22,25,38,40H,1-3,7,11,13-14H2,(H,36,39)/t15?,17?,20-,22-,25+/m0/s1 PKRLPLKJMHKXSC-URSVZBKFSA-N 327558 US9663469, 97 Nuclear receptor ROR-gamma [262-507] 84.7 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327558 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327558&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122662291 384582501 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643612 OC(c1ccc2N([C@H](CC(=O)NC3CCCC3)CCc2c1)S(=O)(=O)c1ccc(F)cc1)(C(F)(F)F)C(F)(F)F InChI=1S/C25H25F7N2O4S/c26-17-7-10-20(11-8-17)39(37,38)34-19(14-22(35)33-18-3-1-2-4-18)9-5-15-13-16(6-12-21(15)34)23(36,24(27,28)29)25(30,31)32/h6-8,10-13,18-19,36H,1-5,9,14H2,(H,33,35)/t19-/m0/s1 ZMCBWKUQESCZDE-IBGZPJMESA-N 327559 US9663469, 98 Nuclear receptor ROR-gamma [262-507] 162 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327559 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327559&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117950255 384582502 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643613 OC[C@H]1C[C@@H](NC(=O)C[C@@H]2CCc3cc(ccc3N2S(=O)(=O)c2ccc(F)cc2)C(O)(C(F)(F)F)C(F)(F)F)[C@H](O)[C@@H]1O InChI=1S/C26H27F7N2O7S/c27-16-3-6-18(7-4-16)43(41,42)35-17(11-21(37)34-19-10-14(12-36)22(38)23(19)39)5-1-13-9-15(2-8-20(13)35)24(40,25(28,29)30)26(31,32)33/h2-4,6-9,14,17,19,22-23,36,38-40H,1,5,10-12H2,(H,34,37)/t14-,17+,19-,22-,23+/m1/s1 DYFPSEYOXLPHRQ-ZRABJEGWSA-N 327560 US9663469, 99 Nuclear receptor ROR-gamma [262-507] 71.5 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327560 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327560&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122662271 384582503 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643614 C[C@]1(F)CCC[C@H]1NC(=O)C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C26H26F8N2O4S/c1-23(28)12-2-3-21(23)35-22(37)14-18-8-4-15-13-16(24(38,25(29,30)31)26(32,33)34)5-11-20(15)36(18)41(39,40)19-9-6-17(27)7-10-19/h5-7,9-11,13,18,21,38H,2-4,8,12,14H2,1H3,(H,35,37)/t18-,21+,23-/m0/s1 HOMCTMTVNIIQOQ-ZEYPLWLESA-N 327561 US9663469, 100 Nuclear receptor ROR-gamma [262-507] 51.1 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327561 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327561&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122662310 384582504 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643615 C[C@@]1(O)CCC[C@H]1NC(=O)C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C26H27F7N2O5S/c1-23(37)12-2-3-21(23)34-22(36)14-18-8-4-15-13-16(24(38,25(28,29)30)26(31,32)33)5-11-20(15)35(18)41(39,40)19-9-6-17(27)7-10-19/h5-7,9-11,13,18,21,37-38H,2-4,8,12,14H2,1H3,(H,34,36)/t18-,21+,23+/m0/s1 NZORVXOOMWOSOK-QTGUNEKASA-N 327562 US9663469, 101 Nuclear receptor ROR-gamma [262-507] 27.9 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327562 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327562&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122662304 384582505 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643616 O[C@@H]1COC[C@H]1NC(=O)C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C24H23F7N2O6S/c25-15-3-6-17(7-4-15)40(37,38)33-16(10-21(35)32-18-11-39-12-20(18)34)5-1-13-9-14(2-8-19(13)33)22(36,23(26,27)28)24(29,30)31/h2-4,6-9,16,18,20,34,36H,1,5,10-12H2,(H,32,35)/t16-,18+,20+/m0/s1 DOXNIYKGJKIXRN-ILZDJORESA-N 327563 US9663469, 102::US9663469, 120::US9663469, 121 Nuclear receptor ROR-gamma [262-507] 32.9 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327563 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327563&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122662292 384582506 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643617 CC1[C@@H](COC1=O)NC(=O)C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C25H23F7N2O6S/c1-13-19(12-40-22(13)36)33-21(35)11-17-6-2-14-10-15(23(37,24(27,28)29)25(30,31)32)3-9-20(14)34(17)41(38,39)18-7-4-16(26)5-8-18/h3-5,7-10,13,17,19,37H,2,6,11-12H2,1H3,(H,33,35)/t13?,17-,19+/m0/s1 WEMISEGUPWASAD-ZJLLDPBHSA-N 327564 US9663469, 103 Nuclear receptor ROR-gamma [262-507] 12.9 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327564 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327564&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122662311 384582507 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643618 CC1(C)[C@@H](COC1=O)NC(=O)C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C26H25F7N2O6S/c1-23(2)20(13-41-22(23)37)34-21(36)12-17-7-3-14-11-15(24(38,25(28,29)30)26(31,32)33)4-10-19(14)35(17)42(39,40)18-8-5-16(27)6-9-18/h4-6,8-11,17,20,38H,3,7,12-13H2,1-2H3,(H,34,36)/t17-,20+/m0/s1 BVRPKODITLMGPP-FXAWDEMLSA-N 327565 US9663469, 104 Nuclear receptor ROR-gamma [262-507] 44.6 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327565 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327565&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122662293 384582508 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643619 OC(=O)c1ncccc1NC(=O)C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C26H20F7N3O6S/c27-16-5-8-18(9-6-16)43(41,42)36-17(13-21(37)35-19-2-1-11-34-22(19)23(38)39)7-3-14-12-15(4-10-20(14)36)24(40,25(28,29)30)26(31,32)33/h1-2,4-6,8-12,17,40H,3,7,13H2,(H,35,37)(H,38,39)/t17-/m0/s1 ZPGATDMQGOXSRW-KRWDZBQOSA-N 327566 US9663469, 105 Nuclear receptor ROR-gamma [262-507] 181 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327566 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327566&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122662305 384582509 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643620 C[C@]1(CCC[C@H]1O)NC(=O)C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C26H27F7N2O5S/c1-23(12-2-3-21(23)36)34-22(37)14-18-8-4-15-13-16(24(38,25(28,29)30)26(31,32)33)5-11-20(15)35(18)41(39,40)19-9-6-17(27)7-10-19/h5-7,9-11,13,18,21,36,38H,2-4,8,12,14H2,1H3,(H,34,37)/t18-,21+,23+/m0/s1 KBNMUXPXKKTSTD-QTGUNEKASA-N 327567 US9663469, 106 Nuclear receptor ROR-gamma [262-507] 33.5 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327567 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327567&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122662294 384582510 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643621 CC(C)(C)OC(=O)N[C@@H]1CC[C@H](C1)NC(=O)C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C30H34F7N3O6S/c1-27(2,3)46-26(42)39-21-9-8-20(15-21)38-25(41)16-22-10-4-17-14-18(28(43,29(32,33)34)30(35,36)37)5-13-24(17)40(22)47(44,45)23-11-6-19(31)7-12-23/h5-7,11-14,20-22,43H,4,8-10,15-16H2,1-3H3,(H,38,41)(H,39,42)/t20-,21-,22+/m1/s1 QULQFAPUGNMHRJ-VSKRKVRLSA-N 327568 US9663469, 107 Nuclear receptor ROR-gamma [262-507] 209 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327568 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327568&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122662362 384582511 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643622 N[C@@H]1CC[C@H](C1)NC(=O)C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C25H26F7N3O4S/c26-16-3-8-20(9-4-16)40(38,39)35-19(13-22(36)34-18-6-5-17(33)12-18)7-1-14-11-15(2-10-21(14)35)23(37,24(27,28)29)25(30,31)32/h2-4,8-11,17-19,37H,1,5-7,12-13,33H2,(H,34,36)/t17-,18-,19+/m1/s1 WOYJOPTYMMIDNR-QRVBRYPASA-N 327569 US9663469, 108 Nuclear receptor ROR-gamma [262-507] 118 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327569 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327569&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122662361 384582512 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643623 OCc1ncccc1NC(=O)C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C26H22F7N3O5S/c27-17-5-8-19(9-6-17)42(40,41)36-18(13-23(38)35-20-2-1-11-34-21(20)14-37)7-3-15-12-16(4-10-22(15)36)24(39,25(28,29)30)26(31,32)33/h1-2,4-6,8-12,18,37,39H,3,7,13-14H2,(H,35,38)/t18-/m0/s1 JQISLIRLFHEPBX-SFHVURJKSA-N 327570 US9663469, 109 Nuclear receptor ROR-gamma [262-507] 48.2 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327570 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327570&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117950042 384582513 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643624 CC(=O)N[C@@H]1CC[C@H](C1)NC(=O)C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C27H28F7N3O5S/c1-15(38)35-19-6-7-20(13-19)36-24(39)14-21-8-2-16-12-17(25(40,26(29,30)31)27(32,33)34)3-11-23(16)37(21)43(41,42)22-9-4-18(28)5-10-22/h3-5,9-12,19-21,40H,2,6-8,13-14H2,1H3,(H,35,38)(H,36,39)/t19-,20-,21+/m1/s1 IOXAIIZYBYDSJI-NJYVYQBISA-N 327571 US9663469, 110 Nuclear receptor ROR-gamma [262-507] 103 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327571 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327571&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122662274 384582514 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643625 N[C@@H]1CCC[C@H]1NC(=O)C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C25H26F7N3O4S/c26-16-6-9-18(10-7-16)40(38,39)35-17(13-22(36)34-20-3-1-2-19(20)33)8-4-14-12-15(5-11-21(14)35)23(37,24(27,28)29)25(30,31)32/h5-7,9-12,17,19-20,37H,1-4,8,13,33H2,(H,34,36)/t17-,19+,20+/m0/s1 HSKHLQFQFFAIJS-DFQSSKMNSA-N 327572 US9663469, 111 Nuclear receptor ROR-gamma [262-507] 185 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327572 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327572&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122662363 384582515 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643626 COC(=O)CC(C)(NC(=O)C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F)C(O)=O InChI=1S/C26H25F7N2O8S/c1-23(22(38)39,13-21(37)43-2)34-20(36)12-17-7-3-14-11-15(24(40,25(28,29)30)26(31,32)33)4-10-19(14)35(17)44(41,42)18-8-5-16(27)6-9-18/h4-6,8-11,17,40H,3,7,12-13H2,1-2H3,(H,34,36)(H,38,39)/t17-,23?/m0/s1 WJMPQLOBGYXHPJ-NVHKAFQKSA-N 327573 US9663469, 112 Nuclear receptor ROR-gamma [262-507] 269 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327573 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327573&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122662391 384582516 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643627 CC(=O)N[C@@H]1CCC[C@H]1NC(=O)C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C27H28F7N3O5S/c1-15(38)35-21-3-2-4-22(21)36-24(39)14-19-9-5-16-13-17(25(40,26(29,30)31)27(32,33)34)6-12-23(16)37(19)43(41,42)20-10-7-18(28)8-11-20/h6-8,10-13,19,21-22,40H,2-5,9,14H2,1H3,(H,35,38)(H,36,39)/t19-,21+,22+/m0/s1 YXHTUMCPBCRTKF-KSEOMHKRSA-N 327574 US9663469, 113 Nuclear receptor ROR-gamma [262-507] 45.8 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327574 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327574&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122662378 384582517 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643628 OC(c1ccc2N([C@H](CC(=O)NC3CC=CC3)CCc2c1)S(=O)(=O)c1ccc(F)cc1)(C(F)(F)F)C(F)(F)F InChI=1S/C25H23F7N2O4S/c26-17-7-10-20(11-8-17)39(37,38)34-19(14-22(35)33-18-3-1-2-4-18)9-5-15-13-16(6-12-21(15)34)23(36,24(27,28)29)25(30,31)32/h1-2,6-8,10-13,18-19,36H,3-5,9,14H2,(H,33,35)/t19-/m0/s1 BCAKXCHWUHAVRG-IBGZPJMESA-N 327575 US9663469, 114 Nuclear receptor ROR-gamma [262-507] 99.9 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327575 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327575&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122662344 384582518 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643629 OCC1COCCN1C(=O)C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C25H25F7N2O6S/c26-17-3-6-20(7-4-17)41(38,39)34-18(12-22(36)33-9-10-40-14-19(33)13-35)5-1-15-11-16(2-8-21(15)34)23(37,24(27,28)29)25(30,31)32/h2-4,6-8,11,18-19,35,37H,1,5,9-10,12-14H2/t18-,19?/m0/s1 SQNXCCNJISWASH-OYKVQYDMSA-N 327576 US9663469, 116 Nuclear receptor ROR-gamma [262-507] 26.5 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327576 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327576&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122660488 384582519 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643630 O[C@H]1CC(C[C@H]1O)NC(=O)C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C25H25F7N2O6S/c26-15-3-6-18(7-4-15)41(39,40)34-17(12-22(37)33-16-10-20(35)21(36)11-16)5-1-13-9-14(2-8-19(13)34)23(38,24(27,28)29)25(30,31)32/h2-4,6-9,16-17,20-21,35-36,38H,1,5,10-12H2,(H,33,37)/t16?,17-,20-,21+/m0/s1 FKUZHQCAPZAYRG-IXZQFDRKSA-N 327577 US9663469, 117 Nuclear receptor ROR-gamma [262-507] 64.2 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327577 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327577&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122662366 384582520 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643631 OCc1cccnc1NC(=O)C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C26H22F7N3O5S/c27-18-5-8-20(9-6-18)42(40,41)36-19(13-22(38)35-23-16(14-37)2-1-11-34-23)7-3-15-12-17(4-10-21(15)36)24(39,25(28,29)30)26(31,32)33/h1-2,4-6,8-12,19,37,39H,3,7,13-14H2,(H,34,35,38)/t19-/m0/s1 LIWKZOSAHCUBDR-IBGZPJMESA-N 327578 US9663469, 118 Nuclear receptor ROR-gamma [262-507] 149 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327578 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327578&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122662307 384582521 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643632 CCOC(=O)N[C@@H]1CCC[C@H]1NC(=O)C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C28H30F7N3O6S/c1-2-44-25(40)37-22-5-3-4-21(22)36-24(39)15-19-10-6-16-14-17(26(41,27(30,31)32)28(33,34)35)7-13-23(16)38(19)45(42,43)20-11-8-18(29)9-12-20/h7-9,11-14,19,21-22,41H,2-6,10,15H2,1H3,(H,36,39)(H,37,40)/t19-,21+,22+/m0/s1 FGMDBVPKUMIOMI-KSEOMHKRSA-N 327579 US9663469, 119 Nuclear receptor ROR-gamma [262-507] 70.0 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327579 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327579&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122662382 384582522 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643633 O[C@@H]1COC[C@H]1NC(=O)C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C24H23F7N2O6S/c25-15-3-6-17(7-4-15)40(37,38)33-16(10-21(35)32-18-11-39-12-20(18)34)5-1-13-9-14(2-8-19(13)33)22(36,23(26,27)28)24(29,30)31/h2-4,6-9,16,18,20,34,36H,1,5,10-12H2,(H,32,35)/t16-,18+,20+/m0/s1 DOXNIYKGJKIXRN-ILZDJORESA-N 327563 US9663469, 102::US9663469, 120::US9663469, 121 Nuclear receptor ROR-gamma [262-507] 14.8 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327563 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327563&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122662292 384582506 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643634 O[C@@H]1COC[C@H]1NC(=O)C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C24H23F7N2O6S/c25-15-3-6-17(7-4-15)40(37,38)33-16(10-21(35)32-18-11-39-12-20(18)34)5-1-13-9-14(2-8-19(13)33)22(36,23(26,27)28)24(29,30)31/h2-4,6-9,16,18,20,34,36H,1,5,10-12H2,(H,32,35)/t16-,18+,20+/m0/s1 DOXNIYKGJKIXRN-ILZDJORESA-N 327563 US9663469, 102::US9663469, 120::US9663469, 121 Nuclear receptor ROR-gamma [262-507] 16.9 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327563 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327563&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122662292 384582506 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643635 CCOC(=O)N1CC(NC(=O)C[C@@H]2CCc3cc(ccc3N2S(=O)(=O)c2ccc(F)cc2)C(O)(C(F)(F)F)C(F)(F)F)C(O)c2ccccc12 InChI=1S/C32H30F7N3O7S/c1-2-49-29(45)41-17-24(28(44)23-5-3-4-6-26(23)41)40-27(43)16-21-11-7-18-15-19(30(46,31(34,35)36)32(37,38)39)8-14-25(18)42(21)50(47,48)22-12-9-20(33)10-13-22/h3-6,8-10,12-15,21,24,28,44,46H,2,7,11,16-17H2,1H3,(H,40,43)/t21-,24?,28?/m0/s1 KUDNBOXTJYSBNM-NWXIOREVSA-N 327582 US9663469, 122 Nuclear receptor ROR-gamma [262-507] 69.2 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327582 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327582&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122662275 384582523 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643636 CN1CC(NC(=O)C[C@@H]2CCc3cc(ccc3N2S(=O)(=O)c2ccc(F)cc2)C(O)(C(F)(F)F)C(F)(F)F)C(O)c2ccccc12 InChI=1S/C30H28F7N3O5S/c1-39-16-23(27(42)22-4-2-3-5-25(22)39)38-26(41)15-20-10-6-17-14-18(28(43,29(32,33)34)30(35,36)37)7-13-24(17)40(20)46(44,45)21-11-8-19(31)9-12-21/h2-5,7-9,11-14,20,23,27,42-43H,6,10,15-16H2,1H3,(H,38,41)/t20-,23?,27?/m0/s1 NJGASGGYMSVBOE-RQOXUDFDSA-N 327583 US9663469, 123 Nuclear receptor ROR-gamma [262-507] 42.7 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327583 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327583&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122662365 384582524 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643637 OC1CS(=O)(=O)CC1NC(=O)C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C24H23F7N2O7S2/c25-15-3-6-17(7-4-15)42(39,40)33-16(10-21(35)32-18-11-41(37,38)12-20(18)34)5-1-13-9-14(2-8-19(13)33)22(36,23(26,27)28)24(29,30)31/h2-4,6-9,16,18,20,34,36H,1,5,10-12H2,(H,32,35)/t16-,18?,20?/m0/s1 BXALSXGHIHTYCZ-VQSBYGRUSA-N 327584 US9663469, 124 Nuclear receptor ROR-gamma [262-507] 41.7 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327584 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327584&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122662317 384582525 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643638 OC1CSCC1NC(=O)C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C24H23F7N2O5S2/c25-15-3-6-17(7-4-15)40(37,38)33-16(10-21(35)32-18-11-39-12-20(18)34)5-1-13-9-14(2-8-19(13)33)22(36,23(26,27)28)24(29,30)31/h2-4,6-9,16,18,20,34,36H,1,5,10-12H2,(H,32,35)/t16-,18?,20?/m0/s1 WSHHNWBTSUFWJJ-VQSBYGRUSA-N 327585 US9663469, 125 Nuclear receptor ROR-gamma [262-507] 23.0 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327585 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327585&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117950017 384582526 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643639 OC(c1ccc2N([C@H](CC(=O)N[C@H]3CCCCC3(O)c3ccccc3)CCc2c1)S(=O)(=O)c1ccc(F)cc1)(C(F)(F)F)C(F)(F)F InChI=1S/C32H31F7N2O5S/c33-23-11-14-25(15-12-23)47(45,46)41-24(19-28(42)40-27-8-4-5-17-29(27,43)21-6-2-1-3-7-21)13-9-20-18-22(10-16-26(20)41)30(44,31(34,35)36)32(37,38)39/h1-3,6-7,10-12,14-16,18,24,27,43-44H,4-5,8-9,13,17,19H2,(H,40,42)/t24-,27-,29?/m0/s1 VDYAPOSSBAOBRS-RDPNNQSWSA-N 327586 US9663469, 126::US9663469, 127 Nuclear receptor ROR-gamma [262-507] 40.4 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327586 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327586&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122662383 384582527 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643640 OC(c1ccc2N([C@H](CC(=O)N[C@H]3CCCCC3(O)c3ccccc3)CCc2c1)S(=O)(=O)c1ccc(F)cc1)(C(F)(F)F)C(F)(F)F InChI=1S/C32H31F7N2O5S/c33-23-11-14-25(15-12-23)47(45,46)41-24(19-28(42)40-27-8-4-5-17-29(27,43)21-6-2-1-3-7-21)13-9-20-18-22(10-16-26(20)41)30(44,31(34,35)36)32(37,38)39/h1-3,6-7,10-12,14-16,18,24,27,43-44H,4-5,8-9,13,17,19H2,(H,40,42)/t24-,27-,29?/m0/s1 VDYAPOSSBAOBRS-RDPNNQSWSA-N 327586 US9663469, 126::US9663469, 127 Nuclear receptor ROR-gamma [262-507] 42.9 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327586 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327586&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122662383 384582527 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643641 CC(C)(O)[C@H](F)CNC(=O)CC1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)c(F)c1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C25H25F9N2O5S/c1-22(2,38)20(28)12-35-21(37)10-15-5-3-13-9-14(23(39,24(29,30)31)25(32,33)34)4-8-19(13)36(15)42(40,41)16-6-7-17(26)18(27)11-16/h4,6-9,11,15,20,38-39H,3,5,10,12H2,1-2H3,(H,35,37)/t15?,20-/m1/s1 CEMJCUOKPZCQCE-YQYDADCPSA-N 327588 US9663469, 129 Nuclear receptor ROR-gamma [262-507] 13.0 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327588 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327588&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117950217 384582528 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643642 OCc1ccncc1NC(=O)C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C26H22F7N3O5S/c27-18-3-6-20(7-4-18)42(40,41)36-19(12-23(38)35-21-13-34-10-9-16(21)14-37)5-1-15-11-17(2-8-22(15)36)24(39,25(28,29)30)26(31,32)33/h2-4,6-11,13,19,37,39H,1,5,12,14H2,(H,35,38)/t19-/m0/s1 ZPSMIGDTZOZECX-IBGZPJMESA-N 327589 US9663469, 130 Nuclear receptor ROR-gamma [262-507] 41.7 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327589 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327589&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122662276 384582529 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643643 CC(C)(O)[C@H](F)CNC(=O)CC1CCc2cc(ccc2N1S(=O)(=O)c1ccc(Cl)cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C25H26ClF7N2O5S/c1-22(2,37)20(27)13-34-21(36)12-17-7-3-14-11-15(23(38,24(28,29)30)25(31,32)33)4-10-19(14)35(17)41(39,40)18-8-5-16(26)6-9-18/h4-6,8-11,17,20,37-38H,3,7,12-13H2,1-2H3,(H,34,36)/t17?,20-/m1/s1 BQEQABBYKJVMAA-UUSAFJCLSA-N 327590 US9663469, 131 Nuclear receptor ROR-gamma [262-507] 35.8 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327590 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327590&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117950232 384582530 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643644 CC(C)(O)[C@H](F)CNC(=O)CC1CCc2cc(ccc2N1S(=O)(=O)c1ccc(Cl)nc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C24H25ClF7N3O5S/c1-21(2,37)18(26)12-34-20(36)10-15-5-3-13-9-14(22(38,23(27,28)29)24(30,31)32)4-7-17(13)35(15)41(39,40)16-6-8-19(25)33-11-16/h4,6-9,11,15,18,37-38H,3,5,10,12H2,1-2H3,(H,34,36)/t15?,18-/m1/s1 ZJYSUZQAEDDJQX-KPMSDPLLSA-N 327591 US9663469, 132 Nuclear receptor ROR-gamma [262-507] 39.2 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327591 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327591&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122662320 384582531 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643645 COc1ccc(cc1)S(=O)(=O)N1C(CC(=O)NC[C@@H](F)C(C)(C)O)CCc2cc(ccc12)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C26H29F7N2O6S/c1-23(2,37)21(27)14-34-22(36)13-17-6-4-15-12-16(24(38,25(28,29)30)26(31,32)33)5-11-20(15)35(17)42(39,40)19-9-7-18(41-3)8-10-19/h5,7-12,17,21,37-38H,4,6,13-14H2,1-3H3,(H,34,36)/t17?,21-/m1/s1 HOUKPKPVRFJXIV-FBLFFUNLSA-N 327592 US9663469, 133 Nuclear receptor ROR-gamma [262-507] 34.6 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327592 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327592&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122662279 384582532 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643646 CC(C)(O)[C@H](F)CNC(=O)CC1CCc2cc(ccc2N1S(=O)(=O)c1ccc(cc1)C#N)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C26H26F7N3O5S/c1-23(2,38)21(27)14-35-22(37)12-18-7-5-16-11-17(24(39,25(28,29)30)26(31,32)33)6-10-20(16)36(18)42(40,41)19-8-3-15(13-34)4-9-19/h3-4,6,8-11,18,21,38-39H,5,7,12,14H2,1-2H3,(H,35,37)/t18?,21-/m1/s1 VILOAZSKOABTAW-BDPMCISCSA-N 327593 US9663469, 134 Nuclear receptor ROR-gamma [262-507] 73.6 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327593 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327593&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122662321 384582533 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643647 OC1CCOCC1NC(=O)C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C25H25F7N2O6S/c26-16-3-6-18(7-4-16)41(38,39)34-17(12-22(36)33-19-13-40-10-9-21(19)35)5-1-14-11-15(2-8-20(14)34)23(37,24(27,28)29)25(30,31)32/h2-4,6-8,11,17,19,21,35,37H,1,5,9-10,12-13H2,(H,33,36)/t17-,19?,21?/m0/s1 BKESMAMIBMVXIJ-OCDPCBSRSA-N 327594 US9663469, 135 Nuclear receptor ROR-gamma [262-507] 80.0 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327594 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327594&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122662368 384582534 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643648 CN1CCOc2cc(cnc12)S(=O)(=O)N1C(CC(=O)NC[C@@H](F)C(C)(C)O)CCc2cc(ccc12)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C27H31F7N4O6S/c1-24(2,40)21(28)14-35-22(39)11-17-6-4-15-10-16(25(41,26(29,30)31)27(32,33)34)5-7-19(15)38(17)45(42,43)18-12-20-23(36-13-18)37(3)8-9-44-20/h5,7,10,12-13,17,21,40-41H,4,6,8-9,11,14H2,1-3H3,(H,35,39)/t17?,21-/m1/s1 SBDBFYFQQMVQFX-FBLFFUNLSA-N 327595 US9663469, 136 Nuclear receptor ROR-gamma [262-507] 1560 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327595 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327595&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122662345 384582535 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643649 OC(c1ccc2N([C@H](CC(=O)NC3CC(F)(F)C3)CCc2c1)S(=O)(=O)c1ccc(F)cc1)(C(F)(F)F)C(F)(F)F InChI=1S/C24H21F9N2O4S/c25-15-3-6-18(7-4-15)40(38,39)35-17(10-20(36)34-16-11-21(26,27)12-16)5-1-13-9-14(2-8-19(13)35)22(37,23(28,29)30)24(31,32)33/h2-4,6-9,16-17,37H,1,5,10-12H2,(H,34,36)/t17-/m0/s1 DNYUDYQWSHXMIP-KRWDZBQOSA-N 327596 US9663469, 137 Nuclear receptor ROR-gamma [262-507] 50.0 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327596 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327596&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122662322 384582536 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643650 OC(c1ccc2N([C@H](CC(=O)NC3COCC3=O)CCc2c1)S(=O)(=O)c1ccc(F)cc1)(C(F)(F)F)C(F)(F)F InChI=1S/C24H21F7N2O6S/c25-15-3-6-17(7-4-15)40(37,38)33-16(10-21(35)32-18-11-39-12-20(18)34)5-1-13-9-14(2-8-19(13)33)22(36,23(26,27)28)24(29,30)31/h2-4,6-9,16,18,36H,1,5,10-12H2,(H,32,35)/t16-,18?/m0/s1 DFTDQOTTYDYILV-ATNAJCNCSA-N 327597 US9663469, 138 Nuclear receptor ROR-gamma [262-507] 100.0 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327597 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327597&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122662367 384582537 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643651 CC1(O)COCC1NC(=O)C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C25H25F7N2O6S/c1-22(36)13-40-12-20(22)33-21(35)11-17-6-2-14-10-15(23(37,24(27,28)29)25(30,31)32)3-9-19(14)34(17)41(38,39)18-7-4-16(26)5-8-18/h3-5,7-10,17,20,36-37H,2,6,11-13H2,1H3,(H,33,35)/t17-,20?,22?/m0/s1 WNBHWRLAZQVRHX-RYHLMMNBSA-N 327598 US9663469, 140 Nuclear receptor ROR-gamma [262-507] 90.0 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327598 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327598&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122662347 384582538 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643652 OC1CCC[C@@H](NC(=O)C[C@@H]2CCc3cc(ccc3N2S(=O)(=O)c2ccc(F)cc2)C(O)(C(F)(F)F)C(F)(F)F)[C@@H]1O InChI=1S/C26H27F7N2O6S/c27-16-6-9-18(10-7-16)42(40,41)35-17(13-22(37)34-19-2-1-3-21(36)23(19)38)8-4-14-12-15(5-11-20(14)35)24(39,25(28,29)30)26(31,32)33/h5-7,9-12,17,19,21,23,36,38-39H,1-4,8,13H2,(H,34,37)/t17-,19+,21?,23-/m0/s1 RYRVSXWTYKLEGO-NSTSXIQSSA-N 327599 US9663469, 141::US9663469, 142 Nuclear receptor ROR-gamma [262-507] 120 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327599 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327599&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117950066 384582539 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643653 OC1CCC[C@@H](NC(=O)C[C@@H]2CCc3cc(ccc3N2S(=O)(=O)c2ccc(F)cc2)C(O)(C(F)(F)F)C(F)(F)F)[C@@H]1O InChI=1S/C26H27F7N2O6S/c27-16-6-9-18(10-7-16)42(40,41)35-17(13-22(37)34-19-2-1-3-21(36)23(19)38)8-4-14-12-15(5-11-20(14)35)24(39,25(28,29)30)26(31,32)33/h5-7,9-12,17,19,21,23,36,38-39H,1-4,8,13H2,(H,34,37)/t17-,19+,21?,23-/m0/s1 RYRVSXWTYKLEGO-NSTSXIQSSA-N 327599 US9663469, 141::US9663469, 142 Nuclear receptor ROR-gamma [262-507] 70.0 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327599 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327599&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117950066 384582539 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643654 O[C@@H]1[C@H](CCCC1(F)F)NC(=O)C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C26H25F9N2O5S/c27-16-5-8-18(9-6-16)43(41,42)37-17(13-21(38)36-19-2-1-11-23(28,29)22(19)39)7-3-14-12-15(4-10-20(14)37)24(40,25(30,31)32)26(33,34)35/h4-6,8-10,12,17,19,22,39-40H,1-3,7,11,13H2,(H,36,38)/t17-,19-,22+/m0/s1 OTBBRRHELUNCAX-LQBOVUBWSA-N 327601 US9663469, 143 Nuclear receptor ROR-gamma [262-507] 70.0 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327601 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327601&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122662323 384582540 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643655 OC(c1ccc2N([C@H](CC(=O)NC3COCCC3=O)CCc2c1)S(=O)(=O)c1ccc(F)cc1)(C(F)(F)F)C(F)(F)F InChI=1S/C25H23F7N2O6S/c26-16-3-6-18(7-4-16)41(38,39)34-17(12-22(36)33-19-13-40-10-9-21(19)35)5-1-14-11-15(2-8-20(14)34)23(37,24(27,28)29)25(30,31)32/h2-4,6-8,11,17,19,37H,1,5,9-10,12-13H2,(H,33,36)/t17-,19?/m0/s1 PLKRXMDIZBUFGJ-KKFHFHRHSA-N 327602 US9663469, 144 Nuclear receptor ROR-gamma [262-507] 170 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327602 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327602&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122662324 384582541 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643656 CC(C)(O)[C@H](F)CNC(=O)C[C@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(cc1)C#N)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C26H26F7N3O5S/c1-23(2,38)21(27)14-35-22(37)12-18-7-5-16-11-17(24(39,25(28,29)30)26(31,32)33)6-10-20(16)36(18)42(40,41)19-8-3-15(13-34)4-9-19/h3-4,6,8-11,18,21,38-39H,5,7,12,14H2,1-2H3,(H,35,37)/t18-,21-/m1/s1 VILOAZSKOABTAW-WIYYLYMNSA-N 327603 US9663469, 145 Nuclear receptor ROR-gamma [262-507] 2590 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327603 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327603&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122662280 384582542 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643657 OC(CNC(=O)C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F)C(F)(F)F InChI=1S/C23H20F10N2O5S/c24-14-3-6-16(7-4-14)41(39,40)35-15(10-19(37)34-11-18(36)21(25,26)27)5-1-12-9-13(2-8-17(12)35)20(38,22(28,29)30)23(31,32)33/h2-4,6-9,15,18,36,38H,1,5,10-11H2,(H,34,37)/t15-,18?/m0/s1 MRSGOCIKEYSWKR-BUSXIPJBSA-N 327604 US9663469, 146 Nuclear receptor ROR-gamma [262-507] 40.0 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327604 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327604&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122662281 384582543 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643658 O[C@H]1[C@@H](CCCC1(F)F)NC(=O)C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C26H25F9N2O5S/c27-16-5-8-18(9-6-16)43(41,42)37-17(13-21(38)36-19-2-1-11-23(28,29)22(19)39)7-3-14-12-15(4-10-20(14)37)24(40,25(30,31)32)26(33,34)35/h4-6,8-10,12,17,19,22,39-40H,1-3,7,11,13H2,(H,36,38)/t17-,19+,22-/m0/s1 OTBBRRHELUNCAX-KPLVRAHFSA-N 327605 US9663469, 147 Nuclear receptor ROR-gamma [262-507] 150 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327605 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327605&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122662390 384582544 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643659 O[C@@H]1COCC[C@H]1NC(=O)C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C25H25F7N2O6S/c26-16-3-6-18(7-4-16)41(38,39)34-17(12-22(36)33-19-9-10-40-13-21(19)35)5-1-14-11-15(2-8-20(14)34)23(37,24(27,28)29)25(30,31)32/h2-4,6-8,11,17,19,21,35,37H,1,5,9-10,12-13H2,(H,33,36)/t17-,19+,21+/m0/s1 SHONJWHEXSFHSY-FBBABVLZSA-N 327606 US9663469, 148 Nuclear receptor ROR-gamma [262-507] 70.0 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327606 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327606&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117950231 384582545 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643660 CC1(O)CCOCC1NC(=O)C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C26H27F7N2O6S/c1-23(37)10-11-41-14-21(23)34-22(36)13-18-6-2-15-12-16(24(38,25(28,29)30)26(31,32)33)3-9-20(15)35(18)42(39,40)19-7-4-17(27)5-8-19/h3-5,7-9,12,18,21,37-38H,2,6,10-11,13-14H2,1H3,(H,34,36)/t18-,21?,23?/m0/s1 UFIBSOHDAYXNPP-RHKCVOJBSA-N 327607 US9663469, 149::US9663469, 150 Nuclear receptor ROR-gamma [262-507] 110 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327607 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327607&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122662282 384582546 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643661 CC1(O)CCOCC1NC(=O)C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C26H27F7N2O6S/c1-23(37)10-11-41-14-21(23)34-22(36)13-18-6-2-15-12-16(24(38,25(28,29)30)26(31,32)33)3-9-20(15)35(18)42(39,40)19-7-4-17(27)5-8-19/h3-5,7-9,12,18,21,37-38H,2,6,10-11,13-14H2,1H3,(H,34,36)/t18-,21?,23?/m0/s1 UFIBSOHDAYXNPP-RHKCVOJBSA-N 327607 US9663469, 149::US9663469, 150 Nuclear receptor ROR-gamma [262-507] 220 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327607 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327607&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122662282 384582546 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643662 OC(c1ccc2N([C@H](CC(=O)NC3CCOCC3)CCc2c1)S(=O)(=O)c1ccc(cc1)C#N)(C(F)(F)F)C(F)(F)F InChI=1S/C26H25F6N3O5S/c27-25(28,29)24(37,26(30,31)32)18-4-8-22-17(13-18)3-5-20(14-23(36)34-19-9-11-40-12-10-19)35(22)41(38,39)21-6-1-16(15-33)2-7-21/h1-2,4,6-8,13,19-20,37H,3,5,9-12,14H2,(H,34,36)/t20-/m0/s1 ZBSKEVWJHGEOCO-FQEVSTJZSA-N 327609 US9663469, 151 Nuclear receptor ROR-gamma [262-507] 250 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327609 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327609&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122662285 384582547 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643663 CC(C)(O)C(F)(F)CNC(=O)C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C25H25F9N2O5S/c1-21(2,38)22(27,28)13-35-20(37)12-17-7-3-14-11-15(23(39,24(29,30)31)25(32,33)34)4-10-19(14)36(17)42(40,41)18-8-5-16(26)6-9-18/h4-6,8-11,17,38-39H,3,7,12-13H2,1-2H3,(H,35,37)/t17-/m0/s1 JQMFXMQXWQFFPA-KRWDZBQOSA-N 327610 US9663469, 152 Nuclear receptor ROR-gamma [262-507] 50.0 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327610 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327610&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122662346 384582548 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643664 OC(c1ccc2N([C@H](CC(=O)Nc3nncs3)CCc2c1)S(=O)(=O)c1ccc(F)cc1)(C(F)(F)F)C(F)(F)F InChI=1S/C22H17F7N4O4S2/c23-14-3-6-16(7-4-14)39(36,37)33-15(10-18(34)31-19-32-30-11-38-19)5-1-12-9-13(2-8-17(12)33)20(35,21(24,25)26)22(27,28)29/h2-4,6-9,11,15,35H,1,5,10H2,(H,31,32,34)/t15-/m0/s1 ACUSUCJVTSEDAF-HNNXBMFYSA-N 327611 US9663469, 153 Nuclear receptor ROR-gamma [262-507] 24.5 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327611 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327611&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117950005 384582549 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643665 CN1CCN(CC1)C(=O)C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C25H26F7N3O4S/c1-33-10-12-34(13-11-33)22(36)15-19-6-2-16-14-17(23(37,24(27,28)29)25(30,31)32)3-9-21(16)35(19)40(38,39)20-7-4-18(26)5-8-20/h3-5,7-9,14,19,37H,2,6,10-13,15H2,1H3/t19-/m0/s1 NVXMPCIQBVWQGT-IBGZPJMESA-N 327612 US9663469, 154 Nuclear receptor ROR-gamma [262-507] 33.7 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327612 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327612&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117950011 384582550 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643666 OC(c1ccc2N([C@H](CC(=O)NCc3ccncc3)CCc2c1)S(=O)(=O)c1ccc(F)cc1)(C(F)(F)F)C(F)(F)F InChI=1S/C26H22F7N3O4S/c27-19-3-6-21(7-4-19)41(39,40)36-20(14-23(37)35-15-16-9-11-34-12-10-16)5-1-17-13-18(2-8-22(17)36)24(38,25(28,29)30)26(31,32)33/h2-4,6-13,20,38H,1,5,14-15H2,(H,35,37)/t20-/m0/s1 ZUOLMCXGDRMSAG-FQEVSTJZSA-N 327613 US9663469, 155 Nuclear receptor ROR-gamma [262-507] 10.0 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327613 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327613&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 91663305 384582551 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643667 CC1(CNC(=O)C[C@@H]2CCc3cc(ccc3N2S(=O)(=O)c2ccc(F)cc2)C(O)(C(F)(F)F)C(F)(F)F)CCCO1 InChI=1S/C26H27F7N2O5S/c1-23(11-2-12-40-23)15-34-22(36)14-19-7-3-16-13-17(24(37,25(28,29)30)26(31,32)33)4-10-21(16)35(19)41(38,39)20-8-5-18(27)6-9-20/h4-6,8-10,13,19,37H,2-3,7,11-12,14-15H2,1H3,(H,34,36)/t19-,23?/m0/s1 ARVXUCGFTXSHFK-HSTJUUNISA-N 327614 US9663469, 156 Nuclear receptor ROR-gamma [262-507] 25.7 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327614 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327614&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117950006 384582552 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643668 OC[C@@H]1CCCN1C(=O)C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C25H25F7N2O5S/c26-17-5-8-20(9-6-17)40(38,39)34-18(13-22(36)33-11-1-2-19(33)14-35)7-3-15-12-16(4-10-21(15)34)23(37,24(27,28)29)25(30,31)32/h4-6,8-10,12,18-19,35,37H,1-3,7,11,13-14H2/t18-,19-/m0/s1 WDRUIGHGKRJBGP-OALUTQOASA-N 327615 US9663469, 157 Nuclear receptor ROR-gamma [262-507] 30.3 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327615 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327615&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117950007 384582553 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643669 OC(c1ccc2N([C@H](CC(=O)N3CCN(CC3)c3ccccc3)CCc2c1)S(=O)(=O)c1ccc(F)cc1)(C(F)(F)F)C(F)(F)F InChI=1S/C30H28F7N3O4S/c31-22-8-11-25(12-9-22)45(43,44)40-24(19-27(41)39-16-14-38(15-17-39)23-4-2-1-3-5-23)10-6-20-18-21(7-13-26(20)40)28(42,29(32,33)34)30(35,36)37/h1-5,7-9,11-13,18,24,42H,6,10,14-17,19H2/t24-/m0/s1 AFPBNBPBMXSLDM-DEOSSOPVSA-N 327616 US9663469, 158 Nuclear receptor ROR-gamma [262-507] 110 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327616 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327616&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122660495 384582554 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643670 OC(c1ccc2N([C@H](CC(=O)N3CCOCC3)CCc2c1)S(=O)(=O)c1ccc(F)cc1)(C(F)(F)F)C(F)(F)F InChI=1S/C24H23F7N2O5S/c25-17-3-6-19(7-4-17)39(36,37)33-18(14-21(34)32-9-11-38-12-10-32)5-1-15-13-16(2-8-20(15)33)22(35,23(26,27)28)24(29,30)31/h2-4,6-8,13,18,35H,1,5,9-12,14H2/t18-/m0/s1 MCRVGGOGVATIRG-SFHVURJKSA-N 327617 US9663469, 159 Nuclear receptor ROR-gamma [262-507] 28.8 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327617 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327617&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117950117 384582555 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643671 CN(C(=O)C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F)c1ccccc1 InChI=1S/C27H23F7N2O4S/c1-35(20-5-3-2-4-6-20)24(37)16-21-11-7-17-15-18(25(38,26(29,30)31)27(32,33)34)8-14-23(17)36(21)41(39,40)22-12-9-19(28)10-13-22/h2-6,8-10,12-15,21,38H,7,11,16H2,1H3/t21-/m0/s1 GOAZPCKDWPGOGB-NRFANRHFSA-N 327618 US9663469, 160 Nuclear receptor ROR-gamma [262-507] 145 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327618 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327618&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117950121 384582556 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643672 OC(c1ccc2N([C@H](CC(=O)Nc3cccnc3)CCc2c1)S(=O)(=O)c1ccc(F)cc1)(C(F)(F)F)C(F)(F)F InChI=1S/C25H20F7N3O4S/c26-17-5-8-20(9-6-17)40(38,39)35-19(13-22(36)34-18-2-1-11-33-14-18)7-3-15-12-16(4-10-21(15)35)23(37,24(27,28)29)25(30,31)32/h1-2,4-6,8-12,14,19,37H,3,7,13H2,(H,34,36)/t19-/m0/s1 HXNLHYUZNKAVHC-IBGZPJMESA-N 327619 US9663469, 161 Nuclear receptor ROR-gamma [262-507] 26.9 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327619 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327619&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117950111 384582557 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643673 OC(c1ccc2N([C@H](CC(=O)NCc3cccnc3)CCc2c1)S(=O)(=O)c1ccc(F)cc1)(C(F)(F)F)C(F)(F)F InChI=1S/C26H22F7N3O4S/c27-19-5-8-21(9-6-19)41(39,40)36-20(13-23(37)35-15-16-2-1-11-34-14-16)7-3-17-12-18(4-10-22(17)36)24(38,25(28,29)30)26(31,32)33/h1-2,4-6,8-12,14,20,38H,3,7,13,15H2,(H,35,37)/t20-/m0/s1 AUHGTDSNRBUXOU-FQEVSTJZSA-N 327620 US9663469, 162 Nuclear receptor ROR-gamma [262-507] 41.6 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327620 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327620&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117950125 384582558 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643674 OCC1CCN(CC1)C(=O)C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C26H27F7N2O5S/c27-19-3-6-21(7-4-19)41(39,40)35-20(14-23(37)34-11-9-16(15-36)10-12-34)5-1-17-13-18(2-8-22(17)35)24(38,25(28,29)30)26(31,32)33/h2-4,6-8,13,16,20,36,38H,1,5,9-12,14-15H2/t20-/m0/s1 AOAGOGCFRLTFQE-FQEVSTJZSA-N 327621 US9663469, 163 Nuclear receptor ROR-gamma [262-507] 12.4 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327621 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327621&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117950137 384582559 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643675 OC(c1ccc2N([C@H](CC(=O)N3CCc4ccccc4C3)CCc2c1)S(=O)(=O)c1ccc(F)cc1)(C(F)(F)F)C(F)(F)F InChI=1S/C29H25F7N2O4S/c30-22-7-10-24(11-8-22)43(41,42)38-23(16-26(39)37-14-13-18-3-1-2-4-20(18)17-37)9-5-19-15-21(6-12-25(19)38)27(40,28(31,32)33)29(34,35)36/h1-4,6-8,10-12,15,23,40H,5,9,13-14,16-17H2/t23-/m0/s1 RIPPVEXRGNFCTM-QHCPKHFHSA-N 327622 US9663469, 164 Nuclear receptor ROR-gamma [262-507] 366 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327622 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327622&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117950138 384582560 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643676 OC(c1ccc2N([C@H](CC(=O)Nc3ccccc3)CCc2c1)S(=O)(=O)c1ccc(F)cc1)(C(F)(F)F)C(F)(F)F InChI=1S/C26H21F7N2O4S/c27-18-8-11-21(12-9-18)40(38,39)35-20(15-23(36)34-19-4-2-1-3-5-19)10-6-16-14-17(7-13-22(16)35)24(37,25(28,29)30)26(31,32)33/h1-5,7-9,11-14,20,37H,6,10,15H2,(H,34,36)/t20-/m0/s1 RIOXXFZGJOWRNY-FQEVSTJZSA-N 327623 US9663469, 165 Nuclear receptor ROR-gamma [262-507] 18.8 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327623 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327623&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117950139 384582561 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643677 CC(=O)NCCNC(=O)C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C24H24F7N3O5S/c1-14(35)32-10-11-33-21(36)13-18-6-2-15-12-16(22(37,23(26,27)28)24(29,30)31)3-9-20(15)34(18)40(38,39)19-7-4-17(25)5-8-19/h3-5,7-9,12,18,37H,2,6,10-11,13H2,1H3,(H,32,35)(H,33,36)/t18-/m0/s1 FEKHDXWCKCDURG-SFHVURJKSA-N 327624 US9663469, 168 Nuclear receptor ROR-gamma [262-507] 24.8 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327624 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327624&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117950149 384582562 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643678 OC(c1ccc2N([C@H](CC(=O)NC3CCN(Cc4ccccc4)C3)CCc2c1)S(=O)(=O)c1ccc(F)cc1)(C(F)(F)F)C(F)(F)F InChI=1S/C31H30F7N3O4S/c32-23-8-11-26(12-9-23)46(44,45)41-25(17-28(42)39-24-14-15-40(19-24)18-20-4-2-1-3-5-20)10-6-21-16-22(7-13-27(21)41)29(43,30(33,34)35)31(36,37)38/h1-5,7-9,11-13,16,24-25,43H,6,10,14-15,17-19H2,(H,39,42)/t24?,25-/m0/s1 ZDZSNGCVWUKMMA-BBMPLOMVSA-N 327625 US9663469, 169 Nuclear receptor ROR-gamma [262-507] 44.7 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327625 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327625&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117950068 384582563 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643679 NC(=O)CCNC(=O)C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C23H22F7N3O5S/c24-15-3-6-17(7-4-15)39(37,38)33-16(12-20(35)32-10-9-19(31)34)5-1-13-11-14(2-8-18(13)33)21(36,22(25,26)27)23(28,29)30/h2-4,6-8,11,16,36H,1,5,9-10,12H2,(H2,31,34)(H,32,35)/t16-/m0/s1 LOGOJYKIBQVZTB-INIZCTEOSA-N 327626 US9663469, 170 Nuclear receptor ROR-gamma [262-507] 24.8 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327626 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327626&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117950102 384582564 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643680 NS(=O)(=O)c1ccc(CNC(=O)C[C@@H]2CCc3cc(ccc3N2S(=O)(=O)c2ccc(F)cc2)C(O)(C(F)(F)F)C(F)(F)F)cc1 InChI=1S/C27H24F7N3O6S2/c28-19-5-10-22(11-6-19)45(42,43)37-20(14-24(38)36-15-16-1-8-21(9-2-16)44(35,40)41)7-3-17-13-18(4-12-23(17)37)25(39,26(29,30)31)27(32,33)34/h1-2,4-6,8-13,20,39H,3,7,14-15H2,(H,36,38)(H2,35,40,41)/t20-/m0/s1 AFMDEFPKHSWDJJ-FQEVSTJZSA-N 327627 US9663469, 171 Nuclear receptor ROR-gamma [262-507] 49.7 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327627 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327627&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117950105 384582565 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643681 NC(=O)CNC(=O)C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C22H20F7N3O5S/c23-14-3-6-16(7-4-14)38(36,37)32-15(10-19(34)31-11-18(30)33)5-1-12-9-13(2-8-17(12)32)20(35,21(24,25)26)22(27,28)29/h2-4,6-9,15,35H,1,5,10-11H2,(H2,30,33)(H,31,34)/t15-/m0/s1 GKKXRZWGUDGBLY-HNNXBMFYSA-N 327628 US9663469, 172 Nuclear receptor ROR-gamma [262-507] 17.0 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327628 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327628&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122662369 384582566 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643682 OC(c1ccc2N([C@H](CC(=O)Nc3ccc4ncsc4c3)CCc2c1)S(=O)(=O)c1ccc(F)cc1)(C(F)(F)F)C(F)(F)F InChI=1S/C27H20F7N3O4S2/c28-17-3-7-20(8-4-17)43(40,41)37-19(13-24(38)36-18-5-9-21-23(12-18)42-14-35-21)6-1-15-11-16(2-10-22(15)37)25(39,26(29,30)31)27(32,33)34/h2-5,7-12,14,19,39H,1,6,13H2,(H,36,38)/t19-/m0/s1 BUWPSTBEGJNIDS-IBGZPJMESA-N 327629 US9663469, 173 Nuclear receptor ROR-gamma [262-507] 30.0 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327629 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327629&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117950106 384582567 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643683 Cc1cnc(CNC(=O)C[C@@H]2CCc3cc(ccc3N2S(=O)(=O)c2ccc(F)cc2)C(O)(C(F)(F)F)C(F)(F)F)cn1 InChI=1S/C26H23F7N4O4S/c1-15-12-35-19(13-34-15)14-36-23(38)11-20-6-2-16-10-17(24(39,25(28,29)30)26(31,32)33)3-9-22(16)37(20)42(40,41)21-7-4-18(27)5-8-21/h3-5,7-10,12-13,20,39H,2,6,11,14H2,1H3,(H,36,38)/t20-/m0/s1 YJWBGJBYDZKFRE-FQEVSTJZSA-N 327630 US9663469, 174 Nuclear receptor ROR-gamma [262-507] 144 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327630 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327630&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117950072 384582568 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643684 COC(C)(C)CNC(=O)C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C25H27F7N2O5S/c1-22(2,39-3)14-33-21(35)13-18-8-4-15-12-16(23(36,24(27,28)29)25(30,31)32)5-11-20(15)34(18)40(37,38)19-9-6-17(26)7-10-19/h5-7,9-12,18,36H,4,8,13-14H2,1-3H3,(H,33,35)/t18-/m0/s1 NEIINYMOHSHPAZ-SFHVURJKSA-N 327631 US9663469, 175 Nuclear receptor ROR-gamma [262-507] 10.3 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327631 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327631&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117950069 384582569 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643685 COC(=O)CNC(=O)C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C23H21F7N2O6S/c1-38-20(34)12-31-19(33)11-16-6-2-13-10-14(21(35,22(25,26)27)23(28,29)30)3-9-18(13)32(16)39(36,37)17-7-4-15(24)5-8-17/h3-5,7-10,16,35H,2,6,11-12H2,1H3,(H,31,33)/t16-/m0/s1 MLNPNTAFQOZRML-INIZCTEOSA-N 327632 US9663469, 176 Nuclear receptor ROR-gamma [262-507] 22.2 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327632 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327632&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117950107 384582570 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643686 OC(c1ccc2N([C@H](CC(=O)NCc3nc4ccccc4s3)CCc2c1)S(=O)(=O)c1ccc(F)cc1)(C(F)(F)F)C(F)(F)F InChI=1S/C28H22F7N3O4S2/c29-18-7-10-20(11-8-18)44(41,42)38-19(14-24(39)36-15-25-37-21-3-1-2-4-23(21)43-25)9-5-16-13-17(6-12-22(16)38)26(40,27(30,31)32)28(33,34)35/h1-4,6-8,10-13,19,40H,5,9,14-15H2,(H,36,39)/t19-/m0/s1 YIKLLLFGZQYTTL-IBGZPJMESA-N 327633 US9663469, 177 Nuclear receptor ROR-gamma [262-507] 192 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327633 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327633&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117950113 384582571 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643687 OC(c1ccc2N([C@H](CC(=O)NCCCN3CCCC3=O)CCc2c1)S(=O)(=O)c1ccc(F)cc1)(C(F)(F)F)C(F)(F)F InChI=1S/C27H28F7N3O5S/c28-19-6-9-21(10-7-19)43(41,42)37-20(16-23(38)35-12-2-14-36-13-1-3-24(36)39)8-4-17-15-18(5-11-22(17)37)25(40,26(29,30)31)27(32,33)34/h5-7,9-11,15,20,40H,1-4,8,12-14,16H2,(H,35,38)/t20-/m0/s1 LFUKEXNWLSBAIV-FQEVSTJZSA-N 327634 US9663469, 178 Nuclear receptor ROR-gamma [262-507] 29.3 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327634 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327634&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117950071 384582572 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643688 OC(c1ccc2N([C@H](CC(=O)NCc3ccccn3)CCc2c1)S(=O)(=O)c1ccc(F)cc1)(C(F)(F)F)C(F)(F)F InChI=1S/C26H22F7N3O4S/c27-18-6-9-21(10-7-18)41(39,40)36-20(14-23(37)35-15-19-3-1-2-12-34-19)8-4-16-13-17(5-11-22(16)36)24(38,25(28,29)30)26(31,32)33/h1-3,5-7,9-13,20,38H,4,8,14-15H2,(H,35,37)/t20-/m0/s1 ZWUNXPIGHUJBSB-FQEVSTJZSA-N 327635 US9663469, 179 Nuclear receptor ROR-gamma [262-507] 125 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327635 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327635&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117950114 384582573 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643689 CN(C)CCNC(=O)C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C24H26F7N3O4S/c1-33(2)12-11-32-21(35)14-18-7-3-15-13-16(22(36,23(26,27)28)24(29,30)31)4-10-20(15)34(18)39(37,38)19-8-5-17(25)6-9-19/h4-6,8-10,13,18,36H,3,7,11-12,14H2,1-2H3,(H,32,35)/t18-/m0/s1 KTXJZUNEXXHDGW-SFHVURJKSA-N 327636 US9663469, 180 Nuclear receptor ROR-gamma [262-507] 37.8 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327636 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327636&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117950089 384582574 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643690 OC(c1ccc2N([C@H](CC(=O)N3CCC(O)(CC3)c3ccccc3)CCc2c1)S(=O)(=O)c1ccc(F)cc1)(C(F)(F)F)C(F)(F)F InChI=1S/C31H29F7N2O5S/c32-23-8-11-25(12-9-23)46(44,45)40-24(19-27(41)39-16-14-28(42,15-17-39)21-4-2-1-3-5-21)10-6-20-18-22(7-13-26(20)40)29(43,30(33,34)35)31(36,37)38/h1-5,7-9,11-13,18,24,42-43H,6,10,14-17,19H2/t24-/m0/s1 UQQLNHNEFRGRFK-DEOSSOPVSA-N 327637 US9663469, 182 Nuclear receptor ROR-gamma [262-507] 32.0 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327637 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327637&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117950108 384582575 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643691 OCCNC(=O)C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C22H21F7N2O5S/c23-15-3-6-17(7-4-15)37(35,36)31-16(12-19(33)30-9-10-32)5-1-13-11-14(2-8-18(13)31)20(34,21(24,25)26)22(27,28)29/h2-4,6-8,11,16,32,34H,1,5,9-10,12H2,(H,30,33)/t16-/m0/s1 QSFCOBZABPBZRM-INIZCTEOSA-N 327638 US9663469, 183 Nuclear receptor ROR-gamma [262-507] 19.9 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327638 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327638&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117950073 384582576 C04080 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643692 OC1CCC(CC1)NC(=O)C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C26H27F7N2O5S/c27-17-3-10-21(11-4-17)41(39,40)35-19(14-23(37)34-18-5-8-20(36)9-6-18)7-1-15-13-16(2-12-22(15)35)24(38,25(28,29)30)26(31,32)33/h2-4,10-13,18-20,36,38H,1,5-9,14H2,(H,34,37)/t18?,19-,20?/m0/s1 GCPFGEWBHXJOOI-GPJFCIFZSA-N 327639 US9663469, 184 Nuclear receptor ROR-gamma [262-507] 18.9 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327639 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327639&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117950029 384582577 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643693 CC1(C)COCCN1C(=O)C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C26H27F7N2O5S/c1-23(2)15-40-12-11-34(23)22(36)14-19-7-3-16-13-17(24(37,25(28,29)30)26(31,32)33)4-10-21(16)35(19)41(38,39)20-8-5-18(27)6-9-20/h4-6,8-10,13,19,37H,3,7,11-12,14-15H2,1-2H3/t19-/m0/s1 TZMFPSTVBPHCRV-IBGZPJMESA-N 327640 US9663469, 185 Nuclear receptor ROR-gamma [262-507] 52.4 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327640 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327640&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117950018 384582578 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643694 COCCNC(=O)C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C23H23F7N2O5S/c1-37-11-10-31-20(33)13-17-6-2-14-12-15(21(34,22(25,26)27)23(28,29)30)3-9-19(14)32(17)38(35,36)18-7-4-16(24)5-8-18/h3-5,7-9,12,17,34H,2,6,10-11,13H2,1H3,(H,31,33)/t17-/m0/s1 NWIVVKXKCQJNCV-KRWDZBQOSA-N 327641 US9663469, 186 Nuclear receptor ROR-gamma [262-507] 73.3 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327641 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327641&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117950023 384582579 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643695 OC(c1ccc2N([C@H](CC(=O)NCC#C)CCc2c1)S(=O)(=O)c1ccc(F)cc1)(C(F)(F)F)C(F)(F)F InChI=1S/C23H19F7N2O4S/c1-2-11-31-20(33)13-17-7-3-14-12-15(21(34,22(25,26)27)23(28,29)30)4-10-19(14)32(17)37(35,36)18-8-5-16(24)6-9-18/h1,4-6,8-10,12,17,34H,3,7,11,13H2,(H,31,33)/t17-/m0/s1 FPYMBYPOUSZDTI-KRWDZBQOSA-N 327642 US9663469, 187 Nuclear receptor ROR-gamma [262-507] 18.9 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327642 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327642&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117950019 384582580 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643696 OC(c1ccc2N([C@H](CC(=O)NC3C[C@@H]3c3ccccc3)CCc2c1)S(=O)(=O)c1ccc(F)cc1)(C(F)(F)F)C(F)(F)F InChI=1S/C29H25F7N2O4S/c30-20-8-11-22(12-9-20)43(41,42)38-21(15-26(39)37-24-16-23(24)17-4-2-1-3-5-17)10-6-18-14-19(7-13-25(18)38)27(40,28(31,32)33)29(34,35)36/h1-5,7-9,11-14,21,23-24,40H,6,10,15-16H2,(H,37,39)/t21-,23+,24?/m0/s1 CVKFPEROFFRLRL-AZIDCLHTSA-N 327643 US9663469, 188 Nuclear receptor ROR-gamma [262-507] 21.0 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327643 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327643&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122660496 384582581 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643697 OC(c1ccc2N([C@H](CC(=O)NC3CCC3)CCc2c1)S(=O)(=O)c1ccc(F)cc1)(C(F)(F)F)C(F)(F)F InChI=1S/C24H23F7N2O4S/c25-16-6-9-19(10-7-16)38(36,37)33-18(13-21(34)32-17-2-1-3-17)8-4-14-12-15(5-11-20(14)33)22(35,23(26,27)28)24(29,30)31/h5-7,9-12,17-18,35H,1-4,8,13H2,(H,32,34)/t18-/m0/s1 QCIKZNIBQZQZEX-SFHVURJKSA-N 327644 US9663469, 189 Nuclear receptor ROR-gamma [262-507] 43.9 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327644 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327644&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117950196 384582582 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643698 COCCN(C)C(=O)C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C24H25F7N2O5S/c1-32(11-12-38-2)21(34)14-18-7-3-15-13-16(22(35,23(26,27)28)24(29,30)31)4-10-20(15)33(18)39(36,37)19-8-5-17(25)6-9-19/h4-6,8-10,13,18,35H,3,7,11-12,14H2,1-2H3/t18-/m0/s1 ROJPJPDYBSCNDC-SFHVURJKSA-N 327645 US9663469, 190 Nuclear receptor ROR-gamma [262-507] 162 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327645 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327645&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117950220 384582583 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643699 CC(=O)N1CCN(CC1)C(=O)C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C26H26F7N3O5S/c1-16(37)34-10-12-35(13-11-34)23(38)15-20-6-2-17-14-18(24(39,25(28,29)30)26(31,32)33)3-9-22(17)36(20)42(40,41)21-7-4-19(27)5-8-21/h3-5,7-9,14,20,39H,2,6,10-13,15H2,1H3/t20-/m0/s1 XULTUZDEBOKZIO-FQEVSTJZSA-N 327646 US9663469, 191 Nuclear receptor ROR-gamma [262-507] 30.9 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327646 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327646&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117950202 384582584 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643700 CN(C)C1CCN(CC1)C(=O)C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C27H30F7N3O4S/c1-35(2)20-11-13-36(14-12-20)24(38)16-21-7-3-17-15-18(25(39,26(29,30)31)27(32,33)34)4-10-23(17)37(21)42(40,41)22-8-5-19(28)6-9-22/h4-6,8-10,15,20-21,39H,3,7,11-14,16H2,1-2H3/t21-/m0/s1 LPSMFPGQTOYVCE-NRFANRHFSA-N 327647 US9663469, 192 Nuclear receptor ROR-gamma [262-507] 110 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327647 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327647&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117950197 384582585 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643701 OC(c1ccc2N([C@H](CC(=O)Nc3ccc(cc3)-c3cnco3)CCc2c1)S(=O)(=O)c1ccc(F)cc1)(C(F)(F)F)C(F)(F)F InChI=1S/C29H22F7N3O5S/c30-20-5-10-23(11-6-20)45(42,43)39-22(14-26(40)38-21-7-1-17(2-8-21)25-15-37-16-44-25)9-3-18-13-19(4-12-24(18)39)27(41,28(31,32)33)29(34,35)36/h1-2,4-8,10-13,15-16,22,41H,3,9,14H2,(H,38,40)/t22-/m0/s1 SSTRXQUDMUCPMK-QFIPXVFZSA-N 327648 US9663469, 193 Nuclear receptor ROR-gamma [262-507] 26.3 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327648 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327648&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117950142 384582586 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643702 OC(c1ccc2N([C@H](CC(=O)NCC3CCS(=O)(=O)C3)CCc2c1)S(=O)(=O)c1ccc(F)cc1)(C(F)(F)F)C(F)(F)F InChI=1S/C25H25F7N2O6S2/c26-18-3-6-20(7-4-18)42(39,40)34-19(12-22(35)33-13-15-9-10-41(37,38)14-15)5-1-16-11-17(2-8-21(16)34)23(36,24(27,28)29)25(30,31)32/h2-4,6-8,11,15,19,36H,1,5,9-10,12-14H2,(H,33,35)/t15?,19-/m0/s1 AAIAPBHTOLZBLS-FUBQLUNQSA-N 327649 US9663469, 194 Nuclear receptor ROR-gamma [262-507] 16.1 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327649 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327649&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122662379 384582587 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643703 OC[C@H](NC(=O)C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F)c1ccccc1 InChI=1S/C28H25F7N2O5S/c29-20-8-11-22(12-9-20)43(41,42)37-21(15-25(39)36-23(16-38)17-4-2-1-3-5-17)10-6-18-14-19(7-13-24(18)37)26(40,27(30,31)32)28(33,34)35/h1-5,7-9,11-14,21,23,38,40H,6,10,15-16H2,(H,36,39)/t21-,23-/m0/s1 UXCZYXRIWFCIAT-GMAHTHKFSA-N 327650 US9663469, 195 Nuclear receptor ROR-gamma [262-507] 35.0 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327650 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327650&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117950134 384582588 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643704 OC[C@@H](NC(=O)C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F)[C@H](O)c1ccccc1 InChI=1S/C29H27F7N2O6S/c30-20-8-11-22(12-9-20)45(43,44)38-21(15-25(40)37-23(16-39)26(41)17-4-2-1-3-5-17)10-6-18-14-19(7-13-24(18)38)27(42,28(31,32)33)29(34,35)36/h1-5,7-9,11-14,21,23,26,39,41-42H,6,10,15-16H2,(H,37,40)/t21-,23+,26+/m0/s1 JVFGIEFHYAKWIJ-POGFHVCPSA-N 327651 US9663469, 197 Nuclear receptor ROR-gamma [262-507] 56.0 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327651 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327651&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117950135 384582589 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643705 OCC(CO)NC(=O)C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C23H23F7N2O6S/c24-15-3-6-18(7-4-15)39(37,38)32-17(10-20(35)31-16(11-33)12-34)5-1-13-9-14(2-8-19(13)32)21(36,22(25,26)27)23(28,29)30/h2-4,6-9,16-17,33-34,36H,1,5,10-12H2,(H,31,35)/t17-/m0/s1 KIMPELSMQFTOLP-KRWDZBQOSA-N 327652 US9663469, 198 Nuclear receptor ROR-gamma [262-507] 35.0 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327652 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327652&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117950010 384582590 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643706 OC[C@H](NC(=O)C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F)[C@@H](O)c1ccccc1 InChI=1S/C29H27F7N2O6S/c30-20-8-11-22(12-9-20)45(43,44)38-21(15-25(40)37-23(16-39)26(41)17-4-2-1-3-5-17)10-6-18-14-19(7-13-24(18)38)27(42,28(31,32)33)29(34,35)36/h1-5,7-9,11-14,21,23,26,39,41-42H,6,10,15-16H2,(H,37,40)/t21-,23-,26-/m0/s1 JVFGIEFHYAKWIJ-KJOQGJGQSA-N 327653 US9663469, 199 Nuclear receptor ROR-gamma [262-507] 30.6 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327653 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327653&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122662370 384582591 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643707 OC[C@@H](NC(=O)C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F)c1ccccc1 InChI=1S/C28H25F7N2O5S/c29-20-8-11-22(12-9-20)43(41,42)37-21(15-25(39)36-23(16-38)17-4-2-1-3-5-17)10-6-18-14-19(7-13-24(18)37)26(40,27(30,31)32)28(33,34)35/h1-5,7-9,11-14,21,23,38,40H,6,10,15-16H2,(H,36,39)/t21-,23+/m0/s1 UXCZYXRIWFCIAT-JTHBVZDNSA-N 327654 US9663469, 200 Nuclear receptor ROR-gamma [262-507] 34.4 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327654 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327654&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117950012 384582592 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643708 OC(c1ccc2N([C@H](CC(=O)NCc3ccccc3)CCc2c1)S(=O)(=O)c1ccc(F)cc1)(C(F)(F)F)C(F)(F)F InChI=1S/C27H23F7N2O4S/c28-20-8-11-22(12-9-20)41(39,40)36-21(15-24(37)35-16-17-4-2-1-3-5-17)10-6-18-14-19(7-13-23(18)36)25(38,26(29,30)31)27(32,33)34/h1-5,7-9,11-14,21,38H,6,10,15-16H2,(H,35,37)/t21-/m0/s1 VQBOIELNXOYKOK-NRFANRHFSA-N 327655 US9663469, 201 Nuclear receptor ROR-gamma [262-507] 118 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327655 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327655&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117950028 384582593 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643709 NC(=O)[C@H](CO)NC(=O)C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C23H22F7N3O6S/c24-14-3-6-16(7-4-14)40(38,39)33-15(10-19(35)32-17(11-34)20(31)36)5-1-12-9-13(2-8-18(12)33)21(37,22(25,26)27)23(28,29)30/h2-4,6-9,15,17,34,37H,1,5,10-11H2,(H2,31,36)(H,32,35)/t15-,17-/m0/s1 JTIJLYDBXNUDOV-RDJZCZTQSA-N 327656 US9663469, 202 Nuclear receptor ROR-gamma [262-507] 65.5 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327656 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327656&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117950026 384582594 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643710 OC[C@H]1CCCN1C(=O)C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C25H25F7N2O5S/c26-17-5-8-20(9-6-17)40(38,39)34-18(13-22(36)33-11-1-2-19(33)14-35)7-3-15-12-16(4-10-21(15)34)23(37,24(27,28)29)25(30,31)32/h4-6,8-10,12,18-19,35,37H,1-3,7,11,13-14H2/t18-,19+/m0/s1 WDRUIGHGKRJBGP-RBUKOAKNSA-N 327657 US9663469, 203 Nuclear receptor ROR-gamma [262-507] 27.3 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327657 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327657&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117950051 384582595 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643711 OC[C@H](Cc1c[nH]cn1)NC(=O)C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F 327658 US9663469, 204 Nuclear receptor ROR-gamma [262-507] 40.2 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327658 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327658&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122662371 384582596 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643712 CC(C)(C)[C@@H](CO)NC(=O)C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C26H29F7N2O5S/c1-23(2,3)21(14-36)34-22(37)13-18-8-4-15-12-16(24(38,25(28,29)30)26(31,32)33)5-11-20(15)35(18)41(39,40)19-9-6-17(27)7-10-19/h5-7,9-12,18,21,36,38H,4,8,13-14H2,1-3H3,(H,34,37)/t18-,21+/m0/s1 QMLDATGCOLXPGV-GHTZIAJQSA-N 327659 US9663469, 205 Nuclear receptor ROR-gamma [262-507] 55.7 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327659 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327659&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117950053 384582597 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643713 C[C@@H](O)[C@H](CO)NC(=O)C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C24H25F7N2O6S/c1-13(35)19(12-34)32-21(36)11-17-6-2-14-10-15(22(37,23(26,27)28)24(29,30)31)3-9-20(14)33(17)40(38,39)18-7-4-16(25)5-8-18/h3-5,7-10,13,17,19,34-35,37H,2,6,11-12H2,1H3,(H,32,36)/t13-,17+,19+/m1/s1 LBFMUBWXMXJBJO-FMEYXAORSA-N 327660 US9663469, 207 Nuclear receptor ROR-gamma [262-507] 45.9 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327660 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327660&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117950093 384582598 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643714 OC[C@@H](Cc1c[nH]cn1)NC(=O)C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F 327661 US9663469, 208 Nuclear receptor ROR-gamma [262-507] 95.3 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327661 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327661&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122662392 384582599 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643715 OC(c1ccc2N([C@H](CC(=O)NCC#N)CCc2c1)S(=O)(=O)c1ccc(F)cc1)(C(F)(F)F)C(F)(F)F InChI=1S/C22H18F7N3O4S/c23-15-3-6-17(7-4-15)37(35,36)32-16(12-19(33)31-10-9-30)5-1-13-11-14(2-8-18(13)32)20(34,21(24,25)26)22(27,28)29/h2-4,6-8,11,16,34H,1,5,10,12H2,(H,31,33)/t16-/m0/s1 SZWILCGSBYSZIQ-INIZCTEOSA-N 327662 US9663469, 209 Nuclear receptor ROR-gamma [262-507] 19.9 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327662 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327662&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117950035 384582600 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643716 C[C@@H](O)[C@@H](CO)NC(=O)C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C24H25F7N2O6S/c1-13(35)19(12-34)32-21(36)11-17-6-2-14-10-15(22(37,23(26,27)28)24(29,30)31)3-9-20(14)33(17)40(38,39)18-7-4-16(25)5-8-18/h3-5,7-10,13,17,19,34-35,37H,2,6,11-12H2,1H3,(H,32,36)/t13-,17+,19-/m1/s1 LBFMUBWXMXJBJO-XVGQJIODSA-N 327663 US9663469, 210 Nuclear receptor ROR-gamma [262-507] 46.9 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327663 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327663&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117950027 384582601 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643717 C[C@H](O)[C@@H](CO)NC(=O)C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C24H25F7N2O6S/c1-13(35)19(12-34)32-21(36)11-17-6-2-14-10-15(22(37,23(26,27)28)24(29,30)31)3-9-20(14)33(17)40(38,39)18-7-4-16(25)5-8-18/h3-5,7-10,13,17,19,34-35,37H,2,6,11-12H2,1H3,(H,32,36)/t13-,17-,19+/m0/s1 LBFMUBWXMXJBJO-SOVGHPHASA-N 327664 US9663469, 211 Nuclear receptor ROR-gamma [262-507] 35.3 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327664 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327664&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117950044 384582602 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643718 C[C@H](O)[C@H](CO)NC(=O)C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C24H25F7N2O6S/c1-13(35)19(12-34)32-21(36)11-17-6-2-14-10-15(22(37,23(26,27)28)24(29,30)31)3-9-20(14)33(17)40(38,39)18-7-4-16(25)5-8-18/h3-5,7-10,13,17,19,34-35,37H,2,6,11-12H2,1H3,(H,32,36)/t13-,17-,19-/m0/s1 LBFMUBWXMXJBJO-IXDGSTSKSA-N 327665 US9663469, 212 Nuclear receptor ROR-gamma [262-507] 68.1 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327665 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327665&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117950045 384582603 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643719 COc1ccccc1C[C@@H](CO)NC(=O)C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C30H29F7N2O6S/c1-45-26-5-3-2-4-19(26)15-22(17-40)38-27(41)16-23-10-6-18-14-20(28(42,29(32,33)34)30(35,36)37)7-13-25(18)39(23)46(43,44)24-11-8-21(31)9-12-24/h2-5,7-9,11-14,22-23,40,42H,6,10,15-17H2,1H3,(H,38,41)/t22-,23-/m0/s1 GPYCHLXEQXSPMB-GOTSBHOMSA-N 327666 US9663469, 213 Nuclear receptor ROR-gamma [262-507] 30.7 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327666 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327666&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117950046 384582604 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643720 OC[C@@H](Cc1ccccc1)NC(=O)C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C29H27F7N2O5S/c30-21-8-11-24(12-9-21)44(42,43)38-23(16-26(40)37-22(17-39)14-18-4-2-1-3-5-18)10-6-19-15-20(7-13-25(19)38)27(41,28(31,32)33)29(34,35)36/h1-5,7-9,11-13,15,22-23,39,41H,6,10,14,16-17H2,(H,37,40)/t22-,23+/m1/s1 UTUGBHMWNBWYOF-PKTZIBPZSA-N 327667 US9663469, 214 Nuclear receptor ROR-gamma [262-507] 46.9 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327667 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327667&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117950047 384582605 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643721 OCC(NC(=O)C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F)c1cccnc1 InChI=1S/C27H24F7N3O5S/c28-19-5-8-21(9-6-19)43(41,42)37-20(13-24(39)36-22(15-38)17-2-1-11-35-14-17)7-3-16-12-18(4-10-23(16)37)25(40,26(29,30)31)27(32,33)34/h1-2,4-6,8-12,14,20,22,38,40H,3,7,13,15H2,(H,36,39)/t20-,22?/m0/s1 MWDXATKXZHMASC-AIBWNMTMSA-N 327668 US9663469, 215::US9663469, 217 Nuclear receptor ROR-gamma [262-507] 51.1 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327668 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327668&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117950036 384582606 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643722 OC[C@H](NC(=O)C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F)c1cccc(CN2CCOCC2)c1 InChI=1S/C33H34F7N3O6S/c34-25-6-9-27(10-7-25)50(47,48)43-26(8-4-23-17-24(5-11-29(23)43)31(46,32(35,36)37)33(38,39)40)18-30(45)41-28(20-44)22-3-1-2-21(16-22)19-42-12-14-49-15-13-42/h1-3,5-7,9-11,16-17,26,28,44,46H,4,8,12-15,18-20H2,(H,41,45)/t26-,28-/m0/s1 WPZXXUBVPHDWBC-XCZPVHLTSA-N 327669 US9663469, 216 Nuclear receptor ROR-gamma [262-507] 76.5 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327669 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327669&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117950094 384582607 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643723 OCC(NC(=O)C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F)c1cccnc1 InChI=1S/C27H24F7N3O5S/c28-19-5-8-21(9-6-19)43(41,42)37-20(13-24(39)36-22(15-38)17-2-1-11-35-14-17)7-3-16-12-18(4-10-23(16)37)25(40,26(29,30)31)27(32,33)34/h1-2,4-6,8-12,14,20,22,38,40H,3,7,13,15H2,(H,36,39)/t20-,22?/m0/s1 MWDXATKXZHMASC-AIBWNMTMSA-N 327668 US9663469, 215::US9663469, 217 Nuclear receptor ROR-gamma [262-507] 31.1 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327668 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327668&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117950036 384582606 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643724 OC(c1ccc2N([C@H](CC(=O)N3CCC(C3)c3c[nH]c4ccccc34)CCc2c1)S(=O)(=O)c1ccc(F)cc1)(C(F)(F)F)C(F)(F)F 327671 US9663469, 218 Nuclear receptor ROR-gamma [262-507] 29.5 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327671 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327671&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122660497 384582608 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643725 OC(c1ccc2N([C@H](CC(=O)N3CCC(C3)Nc3c(-c4ccccc4)c(=O)c3=O)CCc2c1)S(=O)(=O)c1ccc(F)cc1)(C(F)(F)F)C(F)(F)F InChI=1S/C34H28F7N3O6S/c35-22-8-11-25(12-9-22)51(49,50)44-24(10-6-20-16-21(7-13-26(20)44)32(48,33(36,37)38)34(39,40)41)17-27(45)43-15-14-23(18-43)42-29-28(30(46)31(29)47)19-4-2-1-3-5-19/h1-5,7-9,11-13,16,23-24,42,48H,6,10,14-15,17-18H2/t23?,24-/m0/s1 FJJUUSUZNOLBHE-CGAIIQECSA-N 327672 US9663469, 219 Nuclear receptor ROR-gamma [262-507] 67.1 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327672 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327672&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 138404125 384582609 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643726 CN1C2CN(CC2c2ccccc2C1=O)C(=O)C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C32H28F7N3O5S/c1-40-27-17-41(16-25(27)23-4-2-3-5-24(23)29(40)44)28(43)15-21-10-6-18-14-19(30(45,31(34,35)36)32(37,38)39)7-13-26(18)42(21)48(46,47)22-11-8-20(33)9-12-22/h2-5,7-9,11-14,21,25,27,45H,6,10,15-17H2,1H3/t21-,25?,27?/m0/s1 WAQOJXKKQSOBRJ-WSFMRIJLSA-N 327673 US9663469, 220 Nuclear receptor ROR-gamma [262-507] 29.9 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327673 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327673&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122660499 384582610 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643727 OC(c1ccc2N([C@H](CC(=O)N[C@H]3CCC[C@H]3n3ccnc3)CCc2c1)S(=O)(=O)c1ccc(F)cc1)(C(F)(F)F)C(F)(F)F InChI=1S/C28H27F7N4O4S/c29-19-6-9-21(10-7-19)44(42,43)39-20(15-25(40)37-22-2-1-3-24(22)38-13-12-36-16-38)8-4-17-14-18(5-11-23(17)39)26(41,27(30,31)32)28(33,34)35/h5-7,9-14,16,20,22,24,41H,1-4,8,15H2,(H,37,40)/t20-,22-,24+/m0/s1 CIOJZJKDBSPCKS-ODGPQVTHSA-N 327674 US9663469, 221 Nuclear receptor ROR-gamma [262-507] 17.8 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327674 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327674&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122662296 384582611 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643728 OC(c1ccc2N([C@H](CC(=O)N[C@H]3CCCC[C@H]3c3cccnc3)CCc2c1)S(=O)(=O)c1ccc(F)cc1)(C(F)(F)F)C(F)(F)F InChI=1S/C31H30F7N3O4S/c32-22-9-12-24(13-10-22)46(44,45)41-23(17-28(42)40-26-6-2-1-5-25(26)20-4-3-15-39-18-20)11-7-19-16-21(8-14-27(19)41)29(43,30(33,34)35)31(36,37)38/h3-4,8-10,12-16,18,23,25-26,43H,1-2,5-7,11,17H2,(H,40,42)/t23-,25-,26-/m0/s1 VKANCTSTNDYIHL-RNXOBYDBSA-N 327675 US9663469, 222 Nuclear receptor ROR-gamma [262-507] 44.7 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327675 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327675&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117950250 384582612 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643729 OC[C@H](Cc1ccc(F)cc1)NC(=O)C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C29H26F8N2O5S/c30-20-5-1-17(2-6-20)13-22(16-40)38-26(41)15-23-9-3-18-14-19(27(42,28(32,33)34)29(35,36)37)4-12-25(18)39(23)45(43,44)24-10-7-21(31)8-11-24/h1-2,4-8,10-12,14,22-23,40,42H,3,9,13,15-16H2,(H,38,41)/t22-,23-/m0/s1 SMZIQSREQPBRQL-GOTSBHOMSA-N 327676 US9663469, 223 Nuclear receptor ROR-gamma [262-507] 20.1 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327676 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327676&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 129167186 384582613 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643730 OC[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F 327677 US9663469, 224 Nuclear receptor ROR-gamma [262-507] 16.9 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327677 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327677&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117950096 384582614 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643731 OC[C@H](Cc1ccccc1)NC(=O)C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C29H27F7N2O5S/c30-21-8-11-24(12-9-21)44(42,43)38-23(16-26(40)37-22(17-39)14-18-4-2-1-3-5-18)10-6-19-15-20(7-13-25(19)38)27(41,28(31,32)33)29(34,35)36/h1-5,7-9,11-13,15,22-23,39,41H,6,10,14,16-17H2,(H,37,40)/t22-,23-/m0/s1 UTUGBHMWNBWYOF-GOTSBHOMSA-N 327678 US9663469, 225 Nuclear receptor ROR-gamma [262-507] 17.7 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327678 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327678&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122662332 384582615 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643732 COc1ccc(C[C@H]2[C@@H](OC(C)=O)[C@H](O)CN2C(=O)C[C@@H]2CCc3cc(ccc3N2S(=O)(=O)c2ccc(F)cc2)C(O)(C(F)(F)F)C(F)(F)F)cc1 InChI=1S/C34H33F7N2O8S/c1-19(44)51-31-28(15-20-3-10-25(50-2)11-4-20)42(18-29(31)45)30(46)17-24-9-5-21-16-22(32(47,33(36,37)38)34(39,40)41)6-14-27(21)43(24)52(48,49)26-12-7-23(35)8-13-26/h3-4,6-8,10-14,16,24,28-29,31,45,47H,5,9,15,17-18H2,1-2H3/t24-,28-,29+,31+/m0/s1 PHOFJUHHIXDWNE-PJVKZBBJSA-N 327679 US9663469, 226 Nuclear receptor ROR-gamma [262-507] 28.7 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327679 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327679&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 129166399 384582616 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643733 OC(c1ccc2N([C@H](CC(=O)N3CC4NC(=O)c5ccccc5C4C3)CCc2c1)S(=O)(=O)c1ccc(F)cc1)(C(F)(F)F)C(F)(F)F InChI=1S/C31H26F7N3O5S/c32-19-7-10-21(11-8-19)47(45,46)41-20(9-5-17-13-18(6-12-26(17)41)29(44,30(33,34)35)31(36,37)38)14-27(42)40-15-24-22-3-1-2-4-23(22)28(43)39-25(24)16-40/h1-4,6-8,10-13,20,24-25,44H,5,9,14-16H2,(H,39,43)/t20-,24?,25?/m0/s1 UINXOLXXRDZOKS-LXKSKSEUSA-N 327680 US9663469, 227 Nuclear receptor ROR-gamma [262-507] 16.4 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327680 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327680&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122660501 384582617 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643734 OC[C@@H]1CCCC[C@H]1NC(=O)C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C27H29F7N2O5S/c28-19-7-10-21(11-8-19)42(40,41)36-20(14-24(38)35-22-4-2-1-3-17(22)15-37)9-5-16-13-18(6-12-23(16)36)25(39,26(29,30)31)27(32,33)34/h6-8,10-13,17,20,22,37,39H,1-5,9,14-15H2,(H,35,38)/t17-,20-,22+/m0/s1 IBGVAQXRLZNIFR-RBDMOPTHSA-N 327681 US9663469, 228 Nuclear receptor ROR-gamma [262-507] 33.7 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327681 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327681&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117950088 384582618 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643735 OC(c1ccc2N([C@H](CC(=O)N[C@H]3CCCC[C@H]3n3cnc(Cl)c3)CCc2c1)S(=O)(=O)c1ccc(F)cc1)(C(F)(F)F)C(F)(F)F InChI=1S/C29H28ClF7N4O4S/c30-25-15-40(16-38-25)24-4-2-1-3-22(24)39-26(42)14-20-9-5-17-13-18(27(43,28(32,33)34)29(35,36)37)6-12-23(17)41(20)46(44,45)21-10-7-19(31)8-11-21/h6-8,10-13,15-16,20,22,24,43H,1-5,9,14H2,(H,39,42)/t20-,22-,24+/m0/s1 GVSYUVZBOUMXHN-ODGPQVTHSA-N 327682 US9663469, 229 Nuclear receptor ROR-gamma [262-507] 64.4 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327682 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327682&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117950081 384582619 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643736 OC(c1ccc2N([C@H](CC(=O)N3CCC[C@H]3c3nc4ccccc4[nH]3)CCc2c1)S(=O)(=O)c1ccc(F)cc1)(C(F)(F)F)C(F)(F)F 327683 US9663469, 230 Nuclear receptor ROR-gamma [262-507] 111 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327683 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327683&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117950070 384582620 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643737 OC(c1ccc2N([C@H](CC(=O)N3CCCC3c3c[nH]c4ccccc34)CCc2c1)S(=O)(=O)c1ccc(F)cc1)(C(F)(F)F)C(F)(F)F 327684 US9663469, 231::US9663469, 232 Nuclear receptor ROR-gamma [262-507] 53.5 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327684 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327684&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117950246 384582621 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643738 OC(c1ccc2N([C@H](CC(=O)N3CCCC3c3c[nH]c4ccccc34)CCc2c1)S(=O)(=O)c1ccc(F)cc1)(C(F)(F)F)C(F)(F)F 327684 US9663469, 231::US9663469, 232 Nuclear receptor ROR-gamma [262-507] 47.5 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327684 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327684&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117950246 384582621 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643739 COc1ccc(C[C@@H]2[C@H](OC(C)=O)[C@H](O)CN2C(=O)C[C@@H]2CCc3cc(ccc3N2S(=O)(=O)c2ccc(F)cc2)C(O)(C(F)(F)F)C(F)(F)F)cc1 InChI=1S/C34H33F7N2O8S/c1-19(44)51-31-28(15-20-3-10-25(50-2)11-4-20)42(18-29(31)45)30(46)17-24-9-5-21-16-22(32(47,33(36,37)38)34(39,40)41)6-14-27(21)43(24)52(48,49)26-12-7-23(35)8-13-26/h3-4,6-8,10-14,16,24,28-29,31,45,47H,5,9,15,17-18H2,1-2H3/t24-,28+,29+,31-/m0/s1 PHOFJUHHIXDWNE-AFVYQLHNSA-N 327686 US9663469, 233 Nuclear receptor ROR-gamma [262-507] 22.2 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327686 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327686&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117950251 384582622 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643740 OC[C@H]1CCCC[C@H]1NC(=O)C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C27H29F7N2O5S/c28-19-7-10-21(11-8-19)42(40,41)36-20(14-24(38)35-22-4-2-1-3-17(22)15-37)9-5-16-13-18(6-12-23(16)36)25(39,26(29,30)31)27(32,33)34/h6-8,10-13,17,20,22,37,39H,1-5,9,14-15H2,(H,35,38)/t17-,20+,22-/m1/s1 IBGVAQXRLZNIFR-PIPMEXSNSA-N 327687 US9663469, 234 Nuclear receptor ROR-gamma [262-507] 23.2 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327687 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327687&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117950243 384582623 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643741 COc1ccc(cn1)[C@@H]1CCCC[C@@H]1NC(=O)C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C32H32F7N3O5S/c1-47-29-15-7-20(18-40-29)25-4-2-3-5-26(25)41-28(43)17-23-11-6-19-16-21(30(44,31(34,35)36)32(37,38)39)8-14-27(19)42(23)48(45,46)24-12-9-22(33)10-13-24/h7-10,12-16,18,23,25-26,44H,2-6,11,17H2,1H3,(H,41,43)/t23-,25-,26-/m0/s1 DFMRFDFSZDXRMP-RNXOBYDBSA-N 327688 US9663469, 235 Nuclear receptor ROR-gamma [262-507] 41.2 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327688 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327688&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117950247 384582624 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643742 OC(c1ccc2N([C@H](CC(=O)N[C@H]3CCC[C@H]3c3ccc(F)cc3)CCc2c1)S(=O)(=O)c1ccc(F)cc1)(C(F)(F)F)C(F)(F)F InChI=1S/C31H28F8N2O4S/c32-21-8-4-18(5-9-21)25-2-1-3-26(25)40-28(42)17-23-12-6-19-16-20(29(43,30(34,35)36)31(37,38)39)7-15-27(19)41(23)46(44,45)24-13-10-22(33)11-14-24/h4-5,7-11,13-16,23,25-26,43H,1-3,6,12,17H2,(H,40,42)/t23-,25-,26-/m0/s1 PUJIMOPOHHUYBD-RNXOBYDBSA-N 327689 US9663469, 236 Nuclear receptor ROR-gamma [262-507] 18.9 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327689 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327689&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117950244 384582625 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643743 OC(c1ccc2N([C@H](CC(=O)N[C@H]3CCCC[C@H]3c3ccc(Cl)nc3)CCc2c1)S(=O)(=O)c1ccc(F)cc1)(C(F)(F)F)C(F)(F)F InChI=1S/C31H29ClF7N3O4S/c32-27-14-6-19(17-40-27)24-3-1-2-4-25(24)41-28(43)16-22-10-5-18-15-20(29(44,30(34,35)36)31(37,38)39)7-13-26(18)42(22)47(45,46)23-11-8-21(33)9-12-23/h6-9,11-15,17,22,24-25,44H,1-5,10,16H2,(H,41,43)/t22-,24-,25-/m0/s1 UGVLTTJAVDAMDD-HVCNVCAESA-N 327690 US9663469, 237 Nuclear receptor ROR-gamma [262-507] 63.6 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327690 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327690&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117950248 384582626 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643744 OC(c1ccc2N([C@H](CC(=O)N[C@H]3CCCC[C@H]3C(=O)Nc3ccncc3)CCc2c1)S(=O)(=O)c1ccc(F)cc1)(C(F)(F)F)C(F)(F)F InChI=1S/C32H31F7N4O5S/c33-21-7-10-24(11-8-21)49(47,48)43-23(9-5-19-17-20(6-12-27(19)43)30(46,31(34,35)36)32(37,38)39)18-28(44)42-26-4-2-1-3-25(26)29(45)41-22-13-15-40-16-14-22/h6-8,10-17,23,25-26,46H,1-5,9,18H2,(H,42,44)(H,40,41,45)/t23-,25+,26-/m0/s1 KGDJRFTZVICWSH-DMDYGQEQSA-N 327691 US9663469, 238 Nuclear receptor ROR-gamma [262-507] 26.0 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327691 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327691&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117950252 384582627 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643745 OC(c1ccc2N([C@H](CC(=O)N[C@@H]3CCC[C@H]3c3ccc(F)cc3)CCc2c1)S(=O)(=O)c1ccc(F)cc1)(C(F)(F)F)C(F)(F)F InChI=1S/C31H28F8N2O4S/c32-21-8-4-18(5-9-21)25-2-1-3-26(25)40-28(42)17-23-12-6-19-16-20(29(43,30(34,35)36)31(37,38)39)7-15-27(19)41(23)46(44,45)24-13-10-22(33)11-14-24/h4-5,7-11,13-16,23,25-26,43H,1-3,6,12,17H2,(H,40,42)/t23-,25-,26+/m0/s1 PUJIMOPOHHUYBD-AYRHNUGRSA-N 327692 US9663469, 239 Nuclear receptor ROR-gamma [262-507] 33.7 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327692 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327692&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117950259 384582628 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643746 COC(=O)N[C@@H]([C@@H]1CCCCN1C(=O)C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F)c1ccccc1 InChI=1S/C34H34F7N3O6S/c1-50-31(46)42-30(21-7-3-2-4-8-21)28-9-5-6-18-43(28)29(45)20-25-14-10-22-19-23(32(47,33(36,37)38)34(39,40)41)11-17-27(22)44(25)51(48,49)26-15-12-24(35)13-16-26/h2-4,7-8,11-13,15-17,19,25,28,30,47H,5-6,9-10,14,18,20H2,1H3,(H,42,46)/t25-,28-,30+/m0/s1 SWQCFKRQPAMGOJ-QPLJZLFBSA-N 327693 US9663469, 240::US9663469, 241 Nuclear receptor ROR-gamma [262-507] 42.2 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327693 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327693&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117950256 384582629 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643747 COC(=O)N[C@@H]([C@@H]1CCCCN1C(=O)C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F)c1ccccc1 InChI=1S/C34H34F7N3O6S/c1-50-31(46)42-30(21-7-3-2-4-8-21)28-9-5-6-18-43(28)29(45)20-25-14-10-22-19-23(32(47,33(36,37)38)34(39,40)41)11-17-27(22)44(25)51(48,49)26-15-12-24(35)13-16-26/h2-4,7-8,11-13,15-17,19,25,28,30,47H,5-6,9-10,14,18,20H2,1H3,(H,42,46)/t25-,28-,30+/m0/s1 SWQCFKRQPAMGOJ-QPLJZLFBSA-N 327693 US9663469, 240::US9663469, 241 Nuclear receptor ROR-gamma [262-507] 61.5 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327693 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327693&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117950256 384582629 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643748 CC1(C)CN(CC[C@]1(O)c1ccc(Cl)cc1)C(=O)C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C33H32ClF7N2O5S/c1-29(2)19-42(16-15-30(29,45)21-4-7-23(34)8-5-21)28(44)18-25-11-3-20-17-22(31(46,32(36,37)38)33(39,40)41)6-14-27(20)43(25)49(47,48)26-12-9-24(35)10-13-26/h4-10,12-14,17,25,45-46H,3,11,15-16,18-19H2,1-2H3/t25-,30-/m0/s1 IDKACUZKNZOXAD-QCDSWUKFSA-N 327695 US9663469, 242 Nuclear receptor ROR-gamma [262-507] 26.1 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327695 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327695&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117950257 384582630 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643749 Cc1nc[nH]c1C1CCN(CC1)C(=O)C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F 327696 US9663469, 243 Nuclear receptor ROR-gamma [262-507] 23.6 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327696 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327696&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122660503 384582631 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643750 OC(c1ccc2N([C@H](CC(=O)N3CCC(CC3)N3Cc4ccccc4C3=O)CCc2c1)S(=O)(=O)c1ccc(F)cc1)(C(F)(F)F)C(F)(F)F InChI=1S/C33H30F7N3O5S/c34-23-7-10-26(11-8-23)49(47,48)43-25(9-5-20-17-22(6-12-28(20)43)31(46,32(35,36)37)33(38,39)40)18-29(44)41-15-13-24(14-16-41)42-19-21-3-1-2-4-27(21)30(42)45/h1-4,6-8,10-12,17,24-25,46H,5,9,13-16,18-19H2/t25-/m0/s1 VZQQOTDRIONYDF-VWLOTQADSA-N 327697 US9663469, 244 Nuclear receptor ROR-gamma [262-507] 65.1 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327697 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327697&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 129166400 384582632 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643751 OC(c1ccc2N([C@H](CC(=O)N3CCC4(CC3)NC(=O)Cc3ccccc43)CCc2c1)S(=O)(=O)c1ccc(F)cc1)(C(F)(F)F)C(F)(F)F InChI=1S/C33H30F7N3O5S/c34-23-7-10-25(11-8-23)49(47,48)43-24(9-5-21-17-22(6-12-27(21)43)31(46,32(35,36)37)33(38,39)40)19-29(45)42-15-13-30(14-16-42)26-4-2-1-3-20(26)18-28(44)41-30/h1-4,6-8,10-12,17,24,46H,5,9,13-16,18-19H2,(H,41,44)/t24-/m0/s1 FREIYWPAJQURTI-DEOSSOPVSA-N 327698 US9663469, 245 Nuclear receptor ROR-gamma [262-507] 59.4 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327698 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327698&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122660504 384582633 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643752 OCC(NC(=O)C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F)c1cc(Cl)cc(Cl)c1 InChI=1S/C28H23Cl2F7N2O5S/c29-18-10-16(11-19(30)12-18)23(14-40)38-25(41)13-21-5-1-15-9-17(26(42,27(32,33)34)28(35,36)37)2-8-24(15)39(21)45(43,44)22-6-3-20(31)4-7-22/h2-4,6-12,21,23,40,42H,1,5,13-14H2,(H,38,41)/t21-,23?/m0/s1 WFZQYURDLJFESO-BBQAJUCSSA-N 327699 US9663469, 246::US9663469, 247 Nuclear receptor ROR-gamma [262-507] 66.1 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327699 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327699&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117950253 384582634 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643753 OCC(NC(=O)C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F)c1cc(Cl)cc(Cl)c1 InChI=1S/C28H23Cl2F7N2O5S/c29-18-10-16(11-19(30)12-18)23(14-40)38-25(41)13-21-5-1-15-9-17(26(42,27(32,33)34)28(35,36)37)2-8-24(15)39(21)45(43,44)22-6-3-20(31)4-7-22/h2-4,6-12,21,23,40,42H,1,5,13-14H2,(H,38,41)/t21-,23?/m0/s1 WFZQYURDLJFESO-BBQAJUCSSA-N 327699 US9663469, 246::US9663469, 247 Nuclear receptor ROR-gamma [262-507] 25.3 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327699 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327699&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117950253 384582634 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643754 CC(C)c1cc([nH]n1)C(=O)N1CC2(C1)CCC(CC2)C(=O)C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F 327701 US9663469, 248 Nuclear receptor ROR-gamma [262-507] 57.3 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327701 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327701&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 129166401 384582635 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643755 OC(c1ccc2N([C@H](CC(=O)N3CCC(Cn4c5ccccc5[nH]c4=O)CC3)CCc2c1)S(=O)(=O)c1ccc(F)cc1)(C(F)(F)F)C(F)(F)F 327702 US9663469, 249 Nuclear receptor ROR-gamma [262-507] 89.1 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327702 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327702&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 129166402 384582636 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643756 OC(c1ccc2N([C@H](CC(=O)N3CCC4(CC3)OC(=O)Nc3ccccc43)CCc2c1)S(=O)(=O)c1ccc(F)cc1)(C(F)(F)F)C(F)(F)F InChI=1S/C32H28F7N3O6S/c33-21-7-10-23(11-8-21)49(46,47)42-22(9-5-19-17-20(6-12-26(19)42)30(45,31(34,35)36)32(37,38)39)18-27(43)41-15-13-29(14-16-41)24-3-1-2-4-25(24)40-28(44)48-29/h1-4,6-8,10-12,17,22,45H,5,9,13-16,18H2,(H,40,44)/t22-/m0/s1 KDZXTIARHBBZFR-QFIPXVFZSA-N 327703 US9663469, 250 Nuclear receptor ROR-gamma [262-507] 31.2 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327703 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327703&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 129166403 384582637 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643757 OC(c1ccc2N([C@H](CC(=O)N[C@H]3CCCC[C@H]3n3ccnc3)CCc2c1)S(=O)(=O)c1ccc(F)cc1)(C(F)(F)F)C(F)(F)F InChI=1S/C29H29F7N4O4S/c30-20-7-10-22(11-8-20)45(43,44)40-21(16-26(41)38-23-3-1-2-4-25(23)39-14-13-37-17-39)9-5-18-15-19(6-12-24(18)40)27(42,28(31,32)33)29(34,35)36/h6-8,10-15,17,21,23,25,42H,1-5,9,16H2,(H,38,41)/t21-,23-,25+/m0/s1 UTDNSDXDDJUXCX-UMXIMWEHSA-N 327704 US9663469, 251 Nuclear receptor ROR-gamma [262-507] 40.1 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327704 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327704&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117950263 384582638 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643758 OC[C@H](O)[C@H]1CCCCN1C(=O)C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C27H29F7N2O6S/c28-18-6-9-20(10-7-18)43(41,42)36-19(14-24(39)35-12-2-1-3-22(35)23(38)15-37)8-4-16-13-17(5-11-21(16)36)25(40,26(29,30)31)27(32,33)34/h5-7,9-11,13,19,22-23,37-38,40H,1-4,8,12,14-15H2/t19-,22+,23-/m0/s1 VPWCXRAMEIZMQL-PMOQBDJRSA-N 327705 US9663469, 252 Nuclear receptor ROR-gamma [262-507] 16.5 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327705 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327705&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117950144 384582639 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643759 OC(c1ccc2N([C@H](CC(=O)N3CCC(CC3)N3Cc4ccccc4NC3=O)CCc2c1)S(=O)(=O)c1ccc(F)cc1)(C(F)(F)F)C(F)(F)F InChI=1S/C33H31F7N4O5S/c34-23-7-10-26(11-8-23)50(48,49)44-25(9-5-20-17-22(6-12-28(20)44)31(47,32(35,36)37)33(38,39)40)18-29(45)42-15-13-24(14-16-42)43-19-21-3-1-2-4-27(21)41-30(43)46/h1-4,6-8,10-12,17,24-25,47H,5,9,13-16,18-19H2,(H,41,46)/t25-/m0/s1 GTWSXKXRIJMETK-VWLOTQADSA-N 327706 US9663469, 253 Nuclear receptor ROR-gamma [262-507] 172 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327706 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327706&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 129166404 384582640 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643760 OC(c1ccc2N([C@H](CC(=O)N[C@H]3CCC[C@H]3C(=O)Nc3ccncc3)CCc2c1)S(=O)(=O)c1ccc(F)cc1)(C(F)(F)F)C(F)(F)F InChI=1S/C31H29F7N4O5S/c32-20-6-9-23(10-7-20)48(46,47)42-22(8-4-18-16-19(5-11-26(18)42)29(45,30(33,34)35)31(36,37)38)17-27(43)41-25-3-1-2-24(25)28(44)40-21-12-14-39-15-13-21/h5-7,9-16,22,24-25,45H,1-4,8,17H2,(H,41,43)(H,39,40,44)/t22-,24+,25-/m0/s1 SJPINOBMTUDBSR-CAOCKLPOSA-N 327707 US9663469, 254 Nuclear receptor ROR-gamma [262-507] 14.4 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327707 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327707&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117950146 384582641 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643761 C[C@@H](NC(=O)C1CCCN1C(=O)C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F)c1cccc(c1)-c1cccnc1 InChI=1S/C38H35F7N4O5S/c1-23(24-5-2-6-25(19-24)27-7-3-17-46-22-27)47-35(51)33-8-4-18-48(33)34(50)21-30-13-9-26-20-28(36(52,37(40,41)42)38(43,44)45)10-16-32(26)49(30)55(53,54)31-14-11-29(39)12-15-31/h2-3,5-7,10-12,14-17,19-20,22-23,30,33,52H,4,8-9,13,18,21H2,1H3,(H,47,51)/t23-,30+,33?/m1/s1 HCBOTKDQRWDFQX-QNCYGGIPSA-N 327708 US9663469, 255 Nuclear receptor ROR-gamma [262-507] 56.6 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327708 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327708&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117950145 384582642 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643762 C[C@@H](NC(=O)C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F)C(N)=O InChI=1S/C23H22F7N3O5S/c1-12(20(31)35)32-19(34)11-16-6-2-13-10-14(21(36,22(25,26)27)23(28,29)30)3-9-18(13)33(16)39(37,38)17-7-4-15(24)5-8-17/h3-5,7-10,12,16,36H,2,6,11H2,1H3,(H2,31,35)(H,32,34)/t12-,16+/m1/s1 WNCDLPIYJNFMJH-WBMJQRKESA-N 327709 US9663469, 256 Nuclear receptor ROR-gamma [262-507] 34.7 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327709 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327709&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117950038 384582643 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643763 NC(=O)[C@@H](NC(=O)C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F)c1ccccc1 InChI=1S/C28H24F7N3O5S/c29-19-8-11-21(12-9-19)44(42,43)38-20(15-23(39)37-24(25(36)40)16-4-2-1-3-5-16)10-6-17-14-18(7-13-22(17)38)26(41,27(30,31)32)28(33,34)35/h1-5,7-9,11-14,20,24,41H,6,10,15H2,(H2,36,40)(H,37,39)/t20-,24-/m0/s1 OQIRFMIELHLPPJ-RDPSFJRHSA-N 327710 US9663469, 257 Nuclear receptor ROR-gamma [262-507] 33.0 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327710 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327710&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117950037 384582644 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643764 NC(=O)[C@H](NC(=O)C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F)c1ccccc1 InChI=1S/C28H24F7N3O5S/c29-19-8-11-21(12-9-19)44(42,43)38-20(15-23(39)37-24(25(36)40)16-4-2-1-3-5-16)10-6-17-14-18(7-13-22(17)38)26(41,27(30,31)32)28(33,34)35/h1-5,7-9,11-14,20,24,41H,6,10,15H2,(H2,36,40)(H,37,39)/t20-,24+/m0/s1 OQIRFMIELHLPPJ-GBXCKJPGSA-N 327711 US9663469, 258 Nuclear receptor ROR-gamma [262-507] 41.9 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327711 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327711&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117950048 384582645 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643765 CN(C)C(=O)CNC(=O)C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C24H24F7N3O5S/c1-33(2)21(36)13-32-20(35)12-17-7-3-14-11-15(22(37,23(26,27)28)24(29,30)31)4-10-19(14)34(17)40(38,39)18-8-5-16(25)6-9-18/h4-6,8-11,17,37H,3,7,12-13H2,1-2H3,(H,32,35)/t17-/m0/s1 DNVFTQKCWFAOGH-KRWDZBQOSA-N 327712 US9663469, 259 Nuclear receptor ROR-gamma [262-507] 25.4 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327712 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327712&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117950054 384582646 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643766 OC(c1ccc2N([C@H](CC(=O)NCC(=O)N3CCOCC3)CCc2c1)S(=O)(=O)c1ccc(F)cc1)(C(F)(F)F)C(F)(F)F InChI=1S/C26H26F7N3O6S/c27-18-3-6-20(7-4-18)43(40,41)36-19(14-22(37)34-15-23(38)35-9-11-42-12-10-35)5-1-16-13-17(2-8-21(16)36)24(39,25(28,29)30)26(31,32)33/h2-4,6-8,13,19,39H,1,5,9-12,14-15H2,(H,34,37)/t19-/m0/s1 OPPITUNWYDLAJN-IBGZPJMESA-N 327713 US9663469, 260 Nuclear receptor ROR-gamma [262-507] 17.4 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327713 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327713&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117950055 384582647 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643767 NC(=O)C(NC(=O)C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F)C#N InChI=1S/C23H19F7N4O5S/c24-14-3-6-16(7-4-14)40(38,39)34-15(10-19(35)33-17(11-31)20(32)36)5-1-12-9-13(2-8-18(12)34)21(37,22(25,26)27)23(28,29)30/h2-4,6-9,15,17,37H,1,5,10H2,(H2,32,36)(H,33,35)/t15-,17?/m0/s1 WLHNWHQOBPTCNY-MYJWUSKBSA-N 327714 US9663469, 261 Nuclear receptor ROR-gamma [262-507] 22.5 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327714 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327714&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117950270 384582648 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643768 C[C@H](NC(=O)C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F)C(N)=O InChI=1S/C23H22F7N3O5S/c1-12(20(31)35)32-19(34)11-16-6-2-13-10-14(21(36,22(25,26)27)23(28,29)30)3-9-18(13)33(16)39(37,38)17-7-4-15(24)5-8-17/h3-5,7-10,12,16,36H,2,6,11H2,1H3,(H2,31,35)(H,32,34)/t12-,16-/m0/s1 WNCDLPIYJNFMJH-LRDDRELGSA-N 327715 US9663469, 262 Nuclear receptor ROR-gamma [262-507] 23.9 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327715 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327715&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117950276 384582649 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643769 CNC(=O)CNC(=O)C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C23H22F7N3O5S/c1-31-20(35)12-32-19(34)11-16-6-2-13-10-14(21(36,22(25,26)27)23(28,29)30)3-9-18(13)33(16)39(37,38)17-7-4-15(24)5-8-17/h3-5,7-10,16,36H,2,6,11-12H2,1H3,(H,31,35)(H,32,34)/t16-/m0/s1 MZCTXGHYWNTKPO-INIZCTEOSA-N 327716 US9663469, 263 Nuclear receptor ROR-gamma [262-507] 49.3 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327716 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327716&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117950277 384582650 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643770 OC(c1ccc2N([C@H](CC(=O)NCC(=O)N3CCCC3)CCc2c1)S(=O)(=O)c1ccc(F)cc1)(C(F)(F)F)C(F)(F)F InChI=1S/C26H26F7N3O5S/c27-18-5-8-20(9-6-18)42(40,41)36-19(14-22(37)34-15-23(38)35-11-1-2-12-35)7-3-16-13-17(4-10-21(16)36)24(39,25(28,29)30)26(31,32)33/h4-6,8-10,13,19,39H,1-3,7,11-12,14-15H2,(H,34,37)/t19-/m0/s1 YVLLOJNAKJGBDF-IBGZPJMESA-N 327717 US9663469, 264 Nuclear receptor ROR-gamma [262-507] 28.5 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327717 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327717&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117950274 384582651 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643771 OC(c1ccc2N([C@H](CC(=O)N3CCCC3c3cccnc3)CCc2c1)S(=O)(=O)c1ccc(F)cc1)(C(F)(F)F)C(F)(F)F InChI=1S/C29H26F7N3O4S/c30-21-7-10-23(11-8-21)44(42,43)39-22(16-26(40)38-14-2-4-24(38)19-3-1-13-37-17-19)9-5-18-15-20(6-12-25(18)39)27(41,28(31,32)33)29(34,35)36/h1,3,6-8,10-13,15,17,22,24,41H,2,4-5,9,14,16H2/t22-,24?/m0/s1 ZGJNQNWNNBOBMW-OWJIYDKWSA-N 327718 US9663469, 265 Nuclear receptor ROR-gamma [262-507] 47.4 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327718 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327718&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117950059 384582652 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643772 CC1(C)Oc2ccncc2[C@H](NC(=O)C[C@@H]2CCc3cc(ccc3N2S(=O)(=O)c2ccc(F)cc2)C(O)(C(F)(F)F)C(F)(F)F)[C@H]1O InChI=1S/C30H28F7N3O6S/c1-27(2)26(42)25(21-15-38-12-11-23(21)46-27)39-24(41)14-19-7-3-16-13-17(28(43,29(32,33)34)30(35,36)37)4-10-22(16)40(19)47(44,45)20-8-5-18(31)6-9-20/h4-6,8-13,15,19,25-26,42-43H,3,7,14H2,1-2H3,(H,39,41)/t19-,25-,26+/m0/s1 SJDUDMUBVUJENF-RRWZXMNXSA-N 327719 US9663469, 266 Nuclear receptor ROR-gamma [262-507] 83.7 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327719 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327719&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117950060 384582653 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643773 OC(c1ccc2N([C@H](CC(=O)N[C@H]3CCC[C@H]3C(=O)Nc3ccccc3F)CCc2c1)S(=O)(=O)c1ccc(F)cc1)(C(F)(F)F)C(F)(F)F InChI=1S/C32H29F8N3O5S/c33-20-10-13-22(14-11-20)49(47,48)43-21(12-8-18-16-19(9-15-27(18)43)30(46,31(35,36)37)32(38,39)40)17-28(44)41-25-7-3-4-23(25)29(45)42-26-6-2-1-5-24(26)34/h1-2,5-6,9-11,13-16,21,23,25,46H,3-4,7-8,12,17H2,(H,41,44)(H,42,45)/t21-,23+,25-/m0/s1 HHSYFOKUNYOHII-PWWKTKHKSA-N 327720 US9663469, 267 Nuclear receptor ROR-gamma [262-507] 30.4 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327720 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327720&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122660509 384582654 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643774 CC(C)(C)NC(=O)CNC(=O)C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C26H28F7N3O5S/c1-23(2,3)35-22(38)14-34-21(37)13-18-8-4-15-12-16(24(39,25(28,29)30)26(31,32)33)5-11-20(15)36(18)42(40,41)19-9-6-17(27)7-10-19/h5-7,9-12,18,39H,4,8,13-14H2,1-3H3,(H,34,37)(H,35,38)/t18-/m0/s1 BZSCGWZBUJAFHH-SFHVURJKSA-N 327721 US9663469, 268 Nuclear receptor ROR-gamma [262-507] 37.4 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327721 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327721&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117950061 384582655 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643775 CN(C1CCN(C)CC1)C(=O)CNC(=O)C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C29H33F7N4O5S/c1-38-13-11-21(12-14-38)39(2)26(42)17-37-25(41)16-22-7-3-18-15-19(27(43,28(31,32)33)29(34,35)36)4-10-24(18)40(22)46(44,45)23-8-5-20(30)6-9-23/h4-6,8-10,15,21-22,43H,3,7,11-14,16-17H2,1-2H3,(H,37,41)/t22-/m0/s1 ZCVCOJBPCYQLRY-QFIPXVFZSA-N 327722 US9663469, 269 Nuclear receptor ROR-gamma [262-507] 199 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327722 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327722&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117950095 384582656 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643776 O[C@@H]1CCCC[C@H]1NC(=O)C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C26H27F7N2O5S/c27-17-7-10-19(11-8-17)41(39,40)35-18(14-23(37)34-20-3-1-2-4-22(20)36)9-5-15-13-16(6-12-21(15)35)24(38,25(28,29)30)26(31,32)33/h6-8,10-13,18,20,22,36,38H,1-5,9,14H2,(H,34,37)/t18-,20+,22+/m0/s1 MVLBSHGQZKKTKG-CZTZKLFOSA-N 327723 US9663469, 270 Nuclear receptor ROR-gamma [262-507] 21.9 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327723 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327723&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117950056 384582657 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643777 CC1(C)Oc2ccc(cc2[C@@H](O)[C@@H]1NC(=O)C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F)C#N InChI=1S/C32H28F7N3O6S/c1-29(2)28(27(44)23-13-17(16-40)3-12-25(23)48-29)41-26(43)15-21-8-4-18-14-19(30(45,31(34,35)36)32(37,38)39)5-11-24(18)42(21)49(46,47)22-9-6-20(33)7-10-22/h3,5-7,9-14,21,27-28,44-45H,4,8,15H2,1-2H3,(H,41,43)/t21-,27+,28-/m0/s1 NCUSWAOTPCGWSX-TXQOIQMMSA-N 327724 US9663469, 271 Nuclear receptor ROR-gamma [262-507] 50.5 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327724 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327724&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117950049 384582658 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643778 O[C@H]1CCC[C@@H]1NC(=O)C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C25H25F7N2O5S/c26-16-6-9-18(10-7-16)40(38,39)34-17(13-22(36)33-19-2-1-3-21(19)35)8-4-14-12-15(5-11-20(14)34)23(37,24(27,28)29)25(30,31)32/h5-7,9-12,17,19,21,35,37H,1-4,8,13H2,(H,33,36)/t17-,19-,21-/m0/s1 BOFMYIPZOVTKJL-CUWPLCDZSA-N 327725 US9663469, 272 Nuclear receptor ROR-gamma [262-507] 31.9 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327725 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327725&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117950057 384582659 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643779 CC(=O)c1ccc2OC(C)(C)[C@@H](O)[C@H](NC(=O)C[C@@H]3CCc4cc(ccc4N3S(=O)(=O)c3ccc(F)cc3)C(O)(C(F)(F)F)C(F)(F)F)c2c1 InChI=1S/C33H31F7N2O7S/c1-17(43)18-5-13-26-24(15-18)28(29(45)30(2,3)49-26)41-27(44)16-22-9-4-19-14-20(31(46,32(35,36)37)33(38,39)40)6-12-25(19)42(22)50(47,48)23-10-7-21(34)8-11-23/h5-8,10-15,22,28-29,45-46H,4,9,16H2,1-3H3,(H,41,44)/t22-,28+,29-/m0/s1 CGXTVYMESMLGPG-GJDOKZOISA-N 327726 US9663469, 273 Nuclear receptor ROR-gamma [262-507] 104 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327726 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327726&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117950267 384582660 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643780 O[C@H]1[C@H](Cc2ccccc12)NC(=O)C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C29H25F7N2O5S/c30-19-7-10-21(11-8-19)44(42,43)38-20(15-25(39)37-23-14-16-3-1-2-4-22(16)26(23)40)9-5-17-13-18(6-12-24(17)38)27(41,28(31,32)33)29(34,35)36/h1-4,6-8,10-13,20,23,26,40-41H,5,9,14-15H2,(H,37,39)/t20-,23-,26+/m0/s1 LTRAKUCRYWTBKO-AMZDPNTKSA-N 327727 US9663469, 274 Nuclear receptor ROR-gamma [262-507] 29.4 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327727 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327727&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117950264 384582661 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643781 Cc1ncc(CO)c(CNC(=O)C[C@@H]2CCc3cc(ccc3N2S(=O)(=O)c2ccc(F)cc2)C(O)(C(F)(F)F)C(F)(F)F)c1O InChI=1S/C28H26F7N3O6S/c1-15-25(41)22(17(14-39)12-36-15)13-37-24(40)11-20-6-2-16-10-18(26(42,27(30,31)32)28(33,34)35)3-9-23(16)38(20)45(43,44)21-7-4-19(29)5-8-21/h3-5,7-10,12,20,39,41-42H,2,6,11,13-14H2,1H3,(H,37,40)/t20-/m0/s1 KWZULLAIOOXXII-FQEVSTJZSA-N 327728 US9663469, 275 Nuclear receptor ROR-gamma [262-507] 71.0 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327728 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327728&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117950271 384582662 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643782 CC1(C)Oc2ccc(cc2[C@@H](NC(=O)C[C@@H]2CCc3cc(ccc3N2S(=O)(=O)c2ccc(F)cc2)C(O)(C(F)(F)F)C(F)(F)F)[C@@H]1O)C#N InChI=1S/C32H28F7N3O6S/c1-29(2)28(44)27(23-13-17(16-40)3-12-25(23)48-29)41-26(43)15-21-8-4-18-14-19(30(45,31(34,35)36)32(37,38)39)5-11-24(18)42(21)49(46,47)22-9-6-20(33)7-10-22/h3,5-7,9-14,21,27-28,44-45H,4,8,15H2,1-2H3,(H,41,43)/t21-,27+,28-/m0/s1 FXTHYRKOIPPIKM-TXQOIQMMSA-N 327729 US9663469, 276 Nuclear receptor ROR-gamma [262-507] 100 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327729 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327729&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117950268 384582663 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643783 O[C@@H]1Cc2ccccc2[C@@H]1NC(=O)C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C29H25F7N2O5S/c30-19-7-10-21(11-8-19)44(42,43)38-20(15-25(40)37-26-22-4-2-1-3-16(22)14-24(26)39)9-5-17-13-18(6-12-23(17)38)27(41,28(31,32)33)29(34,35)36/h1-4,6-8,10-13,20,24,26,39,41H,5,9,14-15H2,(H,37,40)/t20-,24+,26-/m0/s1 IJTBLHGSDMQVJG-KHMOSXFSSA-N 327730 US9663469, 277 Nuclear receptor ROR-gamma [262-507] 54.8 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327730 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327730&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117950189 384582664 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643784 O[C@H]1CCCC[C@H]1NC(=O)C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C26H27F7N2O5S/c27-17-7-10-19(11-8-17)41(39,40)35-18(14-23(37)34-20-3-1-2-4-22(20)36)9-5-15-13-16(6-12-21(15)35)24(38,25(28,29)30)26(31,32)33/h6-8,10-13,18,20,22,36,38H,1-5,9,14H2,(H,34,37)/t18-,20+,22-/m0/s1 MVLBSHGQZKKTKG-DWLFOUALSA-N 327731 US9663469, 278 Nuclear receptor ROR-gamma [262-507] 24.3 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327731 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327731&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122660510 384582665 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643785 COC(=O)c1ccc2OC(C)(C)[C@@H](O)[C@H](NC(=O)C[C@@H]3CCc4cc(ccc4N3S(=O)(=O)c3ccc(F)cc3)C(O)(C(F)(F)F)C(F)(F)F)c2c1 InChI=1S/C33H31F7N2O8S/c1-30(2)28(44)27(23-15-18(29(45)49-3)5-13-25(23)50-30)41-26(43)16-21-9-4-17-14-19(31(46,32(35,36)37)33(38,39)40)6-12-24(17)42(21)51(47,48)22-10-7-20(34)8-11-22/h5-8,10-15,21,27-28,44,46H,4,9,16H2,1-3H3,(H,41,43)/t21-,27+,28-/m0/s1 LONDQNGPWYTOJS-TXQOIQMMSA-N 327732 US9663469, 279 Nuclear receptor ROR-gamma [262-507] 137 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327732 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327732&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117950225 384582666 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643786 O[C@@H]1CCC[C@@H]1NC(=O)C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C25H25F7N2O5S/c26-16-6-9-18(10-7-16)40(38,39)34-17(13-22(36)33-19-2-1-3-21(19)35)8-4-14-12-15(5-11-20(14)34)23(37,24(27,28)29)25(30,31)32/h5-7,9-12,17,19,21,35,37H,1-4,8,13H2,(H,33,36)/t17-,19-,21+/m0/s1 BOFMYIPZOVTKJL-HFSMHLIXSA-N 327733 US9663469, 280 Nuclear receptor ROR-gamma [262-507] 23.1 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327733 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327733&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117950190 384582667 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643787 CC1(C)[C@@H](O)[C@H](NC(=O)C[C@@H]2CCc3cc(ccc3N2S(=O)(=O)c2ccc(F)cc2)C(O)(C(F)(F)F)C(F)(F)F)c2cc(ccc12)[N+]([O-])=O InChI=1S/C31H28F7N3O7S/c1-28(2)23-11-8-20(41(45)46)14-22(23)26(27(28)43)39-25(42)15-19-7-3-16-13-17(29(44,30(33,34)35)31(36,37)38)4-12-24(16)40(19)49(47,48)21-9-5-18(32)6-10-21/h4-6,8-14,19,26-27,43-44H,3,7,15H2,1-2H3,(H,39,42)/t19-,26+,27-/m0/s1 WOKISMASGWLYKE-PIVNMMCNSA-N 327734 US9663469, 281::US9663469, 282 Nuclear receptor ROR-gamma [262-507] 49.1 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327734 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327734&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122660511 384582668 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643788 CC1(C)[C@@H](O)[C@H](NC(=O)C[C@@H]2CCc3cc(ccc3N2S(=O)(=O)c2ccc(F)cc2)C(O)(C(F)(F)F)C(F)(F)F)c2cc(ccc12)[N+]([O-])=O InChI=1S/C31H28F7N3O7S/c1-28(2)23-11-8-20(41(45)46)14-22(23)26(27(28)43)39-25(42)15-19-7-3-16-13-17(29(44,30(33,34)35)31(36,37)38)4-12-24(16)40(19)49(47,48)21-9-5-18(32)6-10-21/h4-6,8-14,19,26-27,43-44H,3,7,15H2,1-2H3,(H,39,42)/t19-,26+,27-/m0/s1 WOKISMASGWLYKE-PIVNMMCNSA-N 327734 US9663469, 281::US9663469, 282 Nuclear receptor ROR-gamma [262-507] 17.4 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327734 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327734&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122660511 384582668 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643789 OC(c1ccc2N([C@H](CC(=O)NC3CCCOC3)CCc2c1)S(=O)(=O)c1ccc(F)cc1)(C(F)(F)F)C(F)(F)F InChI=1S/C25H25F7N2O5S/c26-17-5-8-20(9-6-17)40(37,38)34-19(13-22(35)33-18-2-1-11-39-14-18)7-3-15-12-16(4-10-21(15)34)23(36,24(27,28)29)25(30,31)32/h4-6,8-10,12,18-19,36H,1-3,7,11,13-14H2,(H,33,35)/t18?,19-/m0/s1 IQJBSBDIEJHTFC-GGYWPGCISA-N 327736 US9663469, 283 Nuclear receptor ROR-gamma [262-507] 36.3 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327736 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327736&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117950050 384582669 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643790 CC1(C)Oc2ccccc2[C@@H](NC(=O)C[C@@H]2CCc3cc(ccc3N2S(=O)(=O)c2ccc(F)cc2)C(O)(C(F)(F)F)C(F)(F)F)[C@@H]1O InChI=1S/C31H29F7N2O6S/c1-28(2)27(42)26(22-5-3-4-6-24(22)46-28)39-25(41)16-20-11-7-17-15-18(29(43,30(33,34)35)31(36,37)38)8-14-23(17)40(20)47(44,45)21-12-9-19(32)10-13-21/h3-6,8-10,12-15,20,26-27,42-43H,7,11,16H2,1-2H3,(H,39,41)/t20-,26+,27-/m0/s1 KSAKQAKISILNKW-BAURHKQJSA-N 327737 US9663469, 284::US9663469, 285 Nuclear receptor ROR-gamma [262-507] 116 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327737 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327737&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117950120 384582670 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643791 CC1(C)Oc2ccccc2[C@@H](NC(=O)C[C@@H]2CCc3cc(ccc3N2S(=O)(=O)c2ccc(F)cc2)C(O)(C(F)(F)F)C(F)(F)F)[C@@H]1O InChI=1S/C31H29F7N2O6S/c1-28(2)27(42)26(22-5-3-4-6-24(22)46-28)39-25(41)16-20-11-7-17-15-18(29(43,30(33,34)35)31(36,37)38)8-14-23(17)40(20)47(44,45)21-12-9-19(32)10-13-21/h3-6,8-10,12-15,20,26-27,42-43H,7,11,16H2,1-2H3,(H,39,41)/t20-,26+,27-/m0/s1 KSAKQAKISILNKW-BAURHKQJSA-N 327737 US9663469, 284::US9663469, 285 Nuclear receptor ROR-gamma [262-507] 108 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327737 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327737&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117950120 384582670 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643792 OC(c1ccc2N([C@H](CC(=O)NC3CCCC3Oc3c(Cl)cccc3Cl)CCc2c1)S(=O)(=O)c1ccc(F)cc1)(C(F)(F)F)C(F)(F)F InChI=1S/C31H27Cl2F7N2O5S/c32-22-3-1-4-23(33)28(22)47-26-6-2-5-24(26)41-27(43)16-20-11-7-17-15-18(29(44,30(35,36)37)31(38,39)40)8-14-25(17)42(20)48(45,46)21-12-9-19(34)10-13-21/h1,3-4,8-10,12-15,20,24,26,44H,2,5-7,11,16H2,(H,41,43)/t20-,24?,26?/m0/s1 KYDUEDDFAHXLNX-IGDXQIGKSA-N 327739 US9663469, 286 Nuclear receptor ROR-gamma [262-507] 170 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327739 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327739&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122660512 384582671 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643793 O[C@H]1CCCC[C@@H]1NC(=O)C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C26H27F7N2O5S/c27-17-7-10-19(11-8-17)41(39,40)35-18(14-23(37)34-20-3-1-2-4-22(20)36)9-5-15-13-16(6-12-21(15)35)24(38,25(28,29)30)26(31,32)33/h6-8,10-13,18,20,22,36,38H,1-5,9,14H2,(H,34,37)/t18-,20-,22-/m0/s1 MVLBSHGQZKKTKG-VCOUNFBDSA-N 327740 US9663469, 287 Nuclear receptor ROR-gamma [262-507] 68.4 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327740 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327740&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117950115 384582672 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643794 CC(C)(C)c1cncc(c1)C(C)(C)NC(=O)C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C32H34F7N3O4S/c1-28(2,3)21-15-22(18-40-17-21)29(4,5)41-27(43)16-24-10-6-19-14-20(30(44,31(34,35)36)32(37,38)39)7-13-26(19)42(24)47(45,46)25-11-8-23(33)9-12-25/h7-9,11-15,17-18,24,44H,6,10,16H2,1-5H3,(H,41,43)/t24-/m0/s1 QALOJXZAEWAGRQ-DEOSSOPVSA-N 327741 US9663469, 288 Nuclear receptor ROR-gamma [262-507] 112 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327741 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327741&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122660513 384582673 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643795 CN(CC(O)c1cccc(O)c1)C(=O)C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C29H27F7N2O6S/c1-37(16-25(40)18-3-2-4-22(39)14-18)26(41)15-21-9-5-17-13-19(27(42,28(31,32)33)29(34,35)36)6-12-24(17)38(21)45(43,44)23-10-7-20(30)8-11-23/h2-4,6-8,10-14,21,25,39-40,42H,5,9,15-16H2,1H3/t21-,25?/m0/s1 YBIFTXUTFXAZDK-BWDMCYIDSA-N 327742 US9663469, 289 Nuclear receptor ROR-gamma [262-507] 71.9 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327742 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327742&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122660514 384582674 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643796 CC(C)(O)CNC(=O)C1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C23H23F7N2O5S/c1-20(2,34)12-31-19(33)18-9-3-13-11-14(21(35,22(25,26)27)23(28,29)30)4-10-17(13)32(18)38(36,37)16-7-5-15(24)6-8-16/h4-8,10-11,18,34-35H,3,9,12H2,1-2H3,(H,31,33) PQOALJYKWPKEOE-UHFFFAOYSA-N 327743 (�) 1-((4-fluorophenyl)sulfonyl)-6-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-N-(2-hydroxy-2-methylpropyl)-1,2,3,4-tetrahydroquinoline-2-carboxamide::US9663469, 290 Nuclear receptor ROR-gamma [262-507] 579 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327743 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327743&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117950147 384582675 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643797 OC1CCN(CC1)C(=O)C1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C24H23F7N2O5S/c25-16-3-5-18(6-4-16)39(37,38)33-19-8-2-15(22(36,23(26,27)28)24(29,30)31)13-14(19)1-7-20(33)21(35)32-11-9-17(34)10-12-32/h2-6,8,13,17,20,34,36H,1,7,9-12H2 HVMOUOBDSCIASG-UHFFFAOYSA-N 327744 (�) (1-((4-fluorophenyl)sulfonyl)-6-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,2,3,4-tetrahydroquinolin-2-yl)(4-hydroxypiperidin-1-yl)methanone::US9663469, 291 Nuclear receptor ROR-gamma [262-507] 182 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327744 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327744&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117950092 384582676 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643798 CC(C)(O)CNC(=O)CC1CSc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C23H23F7N2O5S2/c1-20(2,34)12-31-19(33)10-15-11-38-18-9-13(21(35,22(25,26)27)23(28,29)30)3-8-17(18)32(15)39(36,37)16-6-4-14(24)5-7-16/h3-9,15,34-35H,10-12H2,1-2H3,(H,31,33) DUBUCROMSYFQOW-UHFFFAOYSA-N 327745 (�) 2-(4-((4-fluorophenyl)sulfonyl)-7-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-3,4-dihydro-2H-benzo[b][1,4]thiazin-3-yl)-N-(2-hydroxy-2-methylpropyl)acetamide::US9663469, 292 Nuclear receptor ROR-gamma [262-507] 16.9 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327745 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327745&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117950226 384582677 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643799 O[C@H]1CC[C@@H](CC1)NC(=O)CC1CSc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C25H25F7N2O5S2/c26-15-2-8-19(9-3-15)41(38,39)34-17(12-22(36)33-16-4-6-18(35)7-5-16)13-40-21-11-14(1-10-20(21)34)23(37,24(27,28)29)25(30,31)32/h1-3,8-11,16-18,35,37H,4-7,12-13H2,(H,33,36)/t16-,17?,18- YQPHNXZPCVIQCR-KFZAHXERSA-N 327746 US9663469, 293 Nuclear receptor ROR-gamma [262-507] 46.7 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327746 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327746&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122662341 384582678 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643800 CC(C)(N)CNC(=O)CC1CSc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C23H24F7N3O4S2/c1-20(2,31)12-32-19(34)10-15-11-38-18-9-13(21(35,22(25,26)27)23(28,29)30)3-8-17(18)33(15)39(36,37)16-6-4-14(24)5-7-16/h3-9,15,35H,10-12,31H2,1-2H3,(H,32,34) FXBHTKZKMMCKDJ-UHFFFAOYSA-N 327747 US9663469, 294 Nuclear receptor ROR-gamma [262-507] 179 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327747 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327747&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117950211 384582679 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643801 C[C@](O)(CO)CNC(=O)C[C@@H]1CSc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C23H23F7N2O6S2/c1-20(35,12-33)11-31-19(34)9-15-10-39-18-8-13(21(36,22(25,26)27)23(28,29)30)2-7-17(18)32(15)40(37,38)16-5-3-14(24)4-6-16/h2-8,15,33,35-36H,9-12H2,1H3,(H,31,34)/t15-,20-/m1/s1 SUWATLRCDDPSRM-FOIQADDNSA-N 327748 US9663469, 295 Nuclear receptor ROR-gamma [262-507] 24.4 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327748 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327748&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117950205 384582680 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643802 C[C@](O)(CO)CNC(=O)C[C@H]1CSc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C23H23F7N2O6S2/c1-20(35,12-33)11-31-19(34)9-15-10-39-18-8-13(21(36,22(25,26)27)23(28,29)30)2-7-17(18)32(15)40(37,38)16-5-3-14(24)4-6-16/h2-8,15,33,35-36H,9-12H2,1H3,(H,31,34)/t15-,20+/m0/s1 SUWATLRCDDPSRM-MGPUTAFESA-N 327749 US9663469, 296 Nuclear receptor ROR-gamma [262-507] 69.7 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327749 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327749&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117950206 384582681 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643803 C[C@@](O)(CO)CNC(=O)C[C@@H]1CSc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C23H23F7N2O6S2/c1-20(35,12-33)11-31-19(34)9-15-10-39-18-8-13(21(36,22(25,26)27)23(28,29)30)2-7-17(18)32(15)40(37,38)16-5-3-14(24)4-6-16/h2-8,15,33,35-36H,9-12H2,1H3,(H,31,34)/t15-,20+/m1/s1 SUWATLRCDDPSRM-QRWLVFNGSA-N 327750 US9663469, 297 Nuclear receptor ROR-gamma [262-507] 35.6 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327750 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327750&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117950122 384582682 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643804 C[C@@](O)(CO)CNC(=O)C[C@H]1CSc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C23H23F7N2O6S2/c1-20(35,12-33)11-31-19(34)9-15-10-39-18-8-13(21(36,22(25,26)27)23(28,29)30)2-7-17(18)32(15)40(37,38)16-5-3-14(24)4-6-16/h2-8,15,33,35-36H,9-12H2,1H3,(H,31,34)/t15-,20-/m0/s1 SUWATLRCDDPSRM-YWZLYKJASA-N 327751 US9663469, 298 Nuclear receptor ROR-gamma [262-507] 134 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327751 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327751&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117950124 384582683 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643805 OC(c1ccc2N([C@H](CNC(=O)OCc3ccccc3)CCc2c1)S(=O)(=O)c1ccc(F)cc1)(C(F)(F)F)C(F)(F)F InChI=1S/C27H23F7N2O5S/c28-20-8-11-22(12-9-20)42(39,40)36-21(15-35-24(37)41-16-17-4-2-1-3-5-17)10-6-18-14-19(7-13-23(18)36)25(38,26(29,30)31)27(32,33)34/h1-5,7-9,11-14,21,38H,6,10,15-16H2,(H,35,37)/t21-/m0/s1 OCCANZWESSQQKU-NRFANRHFSA-N 327752 (S)-benzyl ((1-((4-fluorophenyl)sulfonyl)-6-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,2,3,4-tetrahydroquinolin-2-yl)methyl)carbamate::US9663469, 299 Nuclear receptor ROR-gamma [262-507] 260 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327752 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327752&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 138404126 384582684 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643806 NC[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C19H17F7N2O3S/c20-13-3-6-15(7-4-13)32(30,31)28-14(10-27)5-1-11-9-12(2-8-16(11)28)17(29,18(21,22)23)19(24,25)26/h2-4,6-9,14,29H,1,5,10,27H2/t14-/m0/s1 ZMTOEBRUTVMLHO-AWEZNQCLSA-N 327753 Step A: (S)-2-(2-(aminomethyl)-1-((4-fluorophenyl)sulfonyl)-1,2,3,4-tetrahydroquinolin-6-yl)-1,1,1,3,3,3-hexafluoropropan-2-ol, HCl::US9663469, 300 Nuclear receptor ROR-gamma [262-507] 70.0 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327753 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327753&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117941088 384582685 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643807 CC(C)(O)C(=O)NC[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C23H23F7N2O5S/c1-20(2,34)19(33)31-12-16-7-3-13-11-14(21(35,22(25,26)27)23(28,29)30)4-10-18(13)32(16)38(36,37)17-8-5-15(24)6-9-17/h4-6,8-11,16,34-35H,3,7,12H2,1-2H3,(H,31,33)/t16-/m0/s1 CXKWUWYQTJFZKJ-INIZCTEOSA-N 327754 US9663469, 301 Nuclear receptor ROR-gamma [262-507] 40.0 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327754 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327754&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122660524 384582686 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643808 OC(c1ccc2N([C@H](CNC(=O)C3CCOCC3)CCc2c1)S(=O)(=O)c1ccc(F)cc1)(C(F)(F)F)C(F)(F)F InChI=1S/C25H25F7N2O5S/c26-18-3-6-20(7-4-18)40(37,38)34-19(14-33-22(35)15-9-11-39-12-10-15)5-1-16-13-17(2-8-21(16)34)23(36,24(27,28)29)25(30,31)32/h2-4,6-8,13,15,19,36H,1,5,9-12,14H2,(H,33,35)/t19-/m0/s1 IUCDMYLTPTWZDD-IBGZPJMESA-N 327755 US9663469, 302 Nuclear receptor ROR-gamma [262-507] 40.0 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327755 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327755&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122660531 384582687 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643809 OCCC(=O)NC[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C22H21F7N2O5S/c23-15-3-6-17(7-4-15)37(35,36)31-16(12-30-19(33)9-10-32)5-1-13-11-14(2-8-18(13)31)20(34,21(24,25)26)22(27,28)29/h2-4,6-8,11,16,32,34H,1,5,9-10,12H2,(H,30,33)/t16-/m0/s1 QMGZBLNGQUAZHA-INIZCTEOSA-N 327756 US9663469, 303 Nuclear receptor ROR-gamma [262-507] 70.0 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327756 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327756&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122660520 384582688 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643810 COC1CCC(CC1)C(=O)NC[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C27H29F7N2O5S/c1-41-21-9-3-16(4-10-21)24(37)35-15-20-8-2-17-14-18(25(38,26(29,30)31)27(32,33)34)5-13-23(17)36(20)42(39,40)22-11-6-19(28)7-12-22/h5-7,11-14,16,20-21,38H,2-4,8-10,15H2,1H3,(H,35,37)/t16?,20-,21?/m0/s1 LXCLDECWKWAESX-WJAMPBCPSA-N 327757 US9663469, 304 Nuclear receptor ROR-gamma [262-507] 30.0 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327757 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327757&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122660525 384582689 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643811 OC(c1ccc2N([C@H](CNC(=O)Cc3ccccn3)CCc2c1)S(=O)(=O)c1ccc(F)cc1)(C(F)(F)F)C(F)(F)F InChI=1S/C26H22F7N3O4S/c27-18-6-9-21(10-7-18)41(39,40)36-20(15-35-23(37)14-19-3-1-2-12-34-19)8-4-16-13-17(5-11-22(16)36)24(38,25(28,29)30)26(31,32)33/h1-3,5-7,9-13,20,38H,4,8,14-15H2,(H,35,37)/t20-/m0/s1 UWPDLEQWAFBLRH-FQEVSTJZSA-N 327758 US9663469, 305 Nuclear receptor ROR-gamma [262-507] 140 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327758 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327758&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117950266 384582690 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643812 OC(c1ccc2N([C@H](CNC(=O)Cc3cccnc3)CCc2c1)S(=O)(=O)c1ccc(F)cc1)(C(F)(F)F)C(F)(F)F InChI=1S/C26H22F7N3O4S/c27-19-5-8-21(9-6-19)41(39,40)36-20(15-35-23(37)12-16-2-1-11-34-14-16)7-3-17-13-18(4-10-22(17)36)24(38,25(28,29)30)26(31,32)33/h1-2,4-6,8-11,13-14,20,38H,3,7,12,15H2,(H,35,37)/t20-/m0/s1 XODNBJNRELKMDF-FQEVSTJZSA-N 327759 US9663469, 306 Nuclear receptor ROR-gamma [262-507] 190 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327759 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327759&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122660533 384582691 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643813 OC(c1ccc2N([C@H](CNC(=O)Cc3ccncc3)CCc2c1)S(=O)(=O)c1ccc(F)cc1)(C(F)(F)F)C(F)(F)F InChI=1S/C26H22F7N3O4S/c27-19-3-6-21(7-4-19)41(39,40)36-20(15-35-23(37)13-16-9-11-34-12-10-16)5-1-17-14-18(2-8-22(17)36)24(38,25(28,29)30)26(31,32)33/h2-4,6-12,14,20,38H,1,5,13,15H2,(H,35,37)/t20-/m0/s1 RZJACGHXKGFODW-FQEVSTJZSA-N 327760 US9663469, 307 Nuclear receptor ROR-gamma [262-507] 30.0 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327760 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327760&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122660526 384582692 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643814 OC(c1ccc2N([C@H](CNC(=O)c3ccccn3)CCc2c1)S(=O)(=O)c1ccc(F)cc1)(C(F)(F)F)C(F)(F)F InChI=1S/C25H20F7N3O4S/c26-17-6-9-19(10-7-17)40(38,39)35-18(14-34-22(36)20-3-1-2-12-33-20)8-4-15-13-16(5-11-21(15)35)23(37,24(27,28)29)25(30,31)32/h1-3,5-7,9-13,18,37H,4,8,14H2,(H,34,36)/t18-/m0/s1 WBYJXHAHBLFVCP-SFHVURJKSA-N 327761 US9663469, 308 Nuclear receptor ROR-gamma [262-507] 80.0 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327761 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327761&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122660527 384582693 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643815 OC(c1ccc2N([C@H](CNC(=O)c3ccc(nc3)C#N)CCc2c1)S(=O)(=O)c1ccc(F)cc1)(C(F)(F)F)C(F)(F)F InChI=1S/C26H19F7N4O4S/c27-18-4-8-21(9-5-18)42(40,41)37-20(14-36-23(38)16-1-6-19(12-34)35-13-16)7-2-15-11-17(3-10-22(15)37)24(39,25(28,29)30)26(31,32)33/h1,3-6,8-11,13,20,39H,2,7,14H2,(H,36,38)/t20-/m0/s1 QEYSQVREDXOKBJ-FQEVSTJZSA-N 327762 US9663469, 309 Nuclear receptor ROR-gamma [262-507] 50.0 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327762 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327762&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122660518 384582694 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643816 OC(c1ccc2N([C@H](CNC(=O)c3cccnc3)CCc2c1)S(=O)(=O)c1ccc(F)cc1)(C(F)(F)F)C(F)(F)F InChI=1S/C25H20F7N3O4S/c26-18-5-8-20(9-6-18)40(38,39)35-19(14-34-22(36)16-2-1-11-33-13-16)7-3-15-12-17(4-10-21(15)35)23(37,24(27,28)29)25(30,31)32/h1-2,4-6,8-13,19,37H,3,7,14H2,(H,34,36)/t19-/m0/s1 OCYFGDLMPXJMEI-IBGZPJMESA-N 327763 US9663469, 310 Nuclear receptor ROR-gamma [262-507] 60.0 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327763 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327763&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122660521 384582695 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643817 OC(c1ccc2N([C@H](CNC(=O)c3ccncc3)CCc2c1)S(=O)(=O)c1ccc(F)cc1)(C(F)(F)F)C(F)(F)F InChI=1S/C25H20F7N3O4S/c26-18-3-6-20(7-4-18)40(38,39)35-19(14-34-22(36)15-9-11-33-12-10-15)5-1-16-13-17(2-8-21(16)35)23(37,24(27,28)29)25(30,31)32/h2-4,6-13,19,37H,1,5,14H2,(H,34,36)/t19-/m0/s1 SFHKWDBZYVTSPK-IBGZPJMESA-N 327764 US9663469, 311 Nuclear receptor ROR-gamma [262-507] 30.0 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327764 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327764&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122660523 384582696 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643818 COc1ccc(cn1)C(=O)NC[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C26H22F7N3O5S/c1-41-22-11-3-16(13-34-22)23(37)35-14-19-7-2-15-12-17(24(38,25(28,29)30)26(31,32)33)4-10-21(15)36(19)42(39,40)20-8-5-18(27)6-9-20/h3-6,8-13,19,38H,2,7,14H2,1H3,(H,35,37)/t19-/m0/s1 OPRGELNGQOOQKM-IBGZPJMESA-N 327765 US9663469, 313 Nuclear receptor ROR-gamma [262-507] 130 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327765 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327765&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122660535 384582697 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643819 OC(c1ccc2N([C@H](CNC(=O)c3ccnc(F)c3)CCc2c1)S(=O)(=O)c1ccc(F)cc1)(C(F)(F)F)C(F)(F)F InChI=1S/C25H19F8N3O4S/c26-17-3-6-19(7-4-17)41(39,40)36-18(13-35-22(37)15-9-10-34-21(27)12-15)5-1-14-11-16(2-8-20(14)36)23(38,24(28,29)30)25(31,32)33/h2-4,6-12,18,38H,1,5,13H2,(H,35,37)/t18-/m0/s1 XROLFCFATKOEGL-SFHVURJKSA-N 327766 US9663469, 314 Nuclear receptor ROR-gamma [262-507] 30.0 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327766 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327766&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122660528 384582698 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643820 COc1cc(ccn1)C(=O)NC[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C26H22F7N3O5S/c1-41-22-13-16(10-11-34-22)23(37)35-14-19-6-2-15-12-17(24(38,25(28,29)30)26(31,32)33)3-9-21(15)36(19)42(39,40)20-7-4-18(27)5-8-20/h3-5,7-13,19,38H,2,6,14H2,1H3,(H,35,37)/t19-/m0/s1 CZSBBVMQVKNJKU-IBGZPJMESA-N 327767 US9663469, 315 Nuclear receptor ROR-gamma [262-507] 70.0 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327767 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327767&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122660529 384582699 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643821 OCC(O)C(=O)NC[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C22H21F7N2O6S/c23-14-3-6-16(7-4-14)38(36,37)31-15(10-30-19(34)18(33)11-32)5-1-12-9-13(2-8-17(12)31)20(35,21(24,25)26)22(27,28)29/h2-4,6-9,15,18,32-33,35H,1,5,10-11H2,(H,30,34)/t15-,18?/m0/s1 ZSPSYOKSVUWJJS-BUSXIPJBSA-N 327768 US9663469, 316 Nuclear receptor ROR-gamma [262-507] 40.0 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327768 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327768&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122660536 384582700 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643822 CC(C)(N)CC(=O)NC[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C24H26F7N3O4S/c1-21(2,32)12-20(35)33-13-17-7-3-14-11-15(22(36,23(26,27)28)24(29,30)31)4-10-19(14)34(17)39(37,38)18-8-5-16(25)6-9-18/h4-6,8-11,17,36H,3,7,12-13,32H2,1-2H3,(H,33,35)/t17-/m0/s1 PASYYTVKLNADAF-KRWDZBQOSA-N 327769 US9663469, 317 Nuclear receptor ROR-gamma [262-507] 70.0 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327769 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327769&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122660519 384582701 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643823 NC1(CCCC1)C(=O)NC[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C25H26F7N3O4S/c26-17-5-8-19(9-6-17)40(38,39)35-18(14-34-21(36)22(33)11-1-2-12-22)7-3-15-13-16(4-10-20(15)35)23(37,24(27,28)29)25(30,31)32/h4-6,8-10,13,18,37H,1-3,7,11-12,14,33H2,(H,34,36)/t18-/m0/s1 WZTTUSOPFXOZGM-SFHVURJKSA-N 327770 US9663469, 318 Nuclear receptor ROR-gamma [262-507] 100.0 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327770 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327770&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122660537 384582702 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643824 CC(=O)N1CCC(CC1)C(=O)NC[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C27H28F7N3O5S/c1-16(38)36-12-10-17(11-13-36)24(39)35-15-21-6-2-18-14-19(25(40,26(29,30)31)27(32,33)34)3-9-23(18)37(21)43(41,42)22-7-4-20(28)5-8-22/h3-5,7-9,14,17,21,40H,2,6,10-13,15H2,1H3,(H,35,39)/t21-/m0/s1 KSSVQBXNLITGOL-NRFANRHFSA-N 327771 US9663469, 319 Nuclear receptor ROR-gamma [262-507] 80.0 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327771 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327771&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122660522 384582703 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643825 NC(C(=O)NC[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F)C(F)(F)F InChI=1S/C22H19F10N3O4S/c23-13-3-6-15(7-4-13)40(38,39)35-14(10-34-18(36)17(33)20(24,25)26)5-1-11-9-12(2-8-16(11)35)19(37,21(27,28)29)22(30,31)32/h2-4,6-9,14,17,37H,1,5,10,33H2,(H,34,36)/t14-,17?/m0/s1 CNAMPFFAFZYNOM-MBIQTGHCSA-N 327772 US9663469, 320 Nuclear receptor ROR-gamma [262-507] 20.0 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327772 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327772&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122660538 384582704 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643826 NC1(COC1)C(=O)NC[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C23H22F7N3O5S/c24-15-3-6-17(7-4-15)39(36,37)33-16(10-32-19(34)20(31)11-38-12-20)5-1-13-9-14(2-8-18(13)33)21(35,22(25,26)27)23(28,29)30/h2-4,6-9,16,35H,1,5,10-12,31H2,(H,32,34)/t16-/m0/s1 XAAFHNVPMAPTTH-INIZCTEOSA-N 327773 US9663469, 321 Nuclear receptor ROR-gamma [262-507] 20.0 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327773 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327773&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122660530 384582705 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643827 OC(c1ccc2N([C@H](CNC(=O)C3CNC(=O)N3)CCc2c1)S(=O)(=O)c1ccc(F)cc1)(C(F)(F)F)C(F)(F)F InChI=1S/C23H21F7N4O5S/c24-14-3-6-16(7-4-14)40(38,39)34-15(10-31-19(35)17-11-32-20(36)33-17)5-1-12-9-13(2-8-18(12)34)21(37,22(25,26)27)23(28,29)30/h2-4,6-9,15,17,37H,1,5,10-11H2,(H,31,35)(H2,32,33,36)/t15-,17?/m0/s1 KXXUSRAKHHXMCV-MYJWUSKBSA-N 327774 US9663469, 322 Nuclear receptor ROR-gamma [262-507] 60.0 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327774 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327774&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117950104 384582706 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643828 N[C@H](Cc1ccccc1)[C@H](O)C(=O)NC[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C29H28F7N3O5S/c30-20-8-11-22(12-9-20)45(43,44)39-21(16-38-26(41)25(40)23(37)14-17-4-2-1-3-5-17)10-6-18-15-19(7-13-24(18)39)27(42,28(31,32)33)29(34,35)36/h1-5,7-9,11-13,15,21,23,25,40,42H,6,10,14,16,37H2,(H,38,41)/t21-,23+,25-/m0/s1 QCWAVKSEDLCGHN-PWWKTKHKSA-N 327775 US9663469, 323 Nuclear receptor ROR-gamma [262-507] 60.0 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327775 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327775&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117950127 384582707 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643829 N[C@@H](CNC(N)=O)C(=O)NC[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C23H24F7N5O5S/c24-14-3-6-16(7-4-14)41(39,40)35-15(10-33-19(36)17(31)11-34-20(32)37)5-1-12-9-13(2-8-18(12)35)21(38,22(25,26)27)23(28,29)30/h2-4,6-9,15,17,38H,1,5,10-11,31H2,(H,33,36)(H3,32,34,37)/t15-,17-/m0/s1 WHIIGVPQETVHTF-RDJZCZTQSA-N 327776 US9663469, 324 Nuclear receptor ROR-gamma [262-507] 20.0 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327776 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327776&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122660534 384582708 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643830 CC(C)(O)[C@@H](N)C(=O)NC[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C24H26F7N3O5S/c1-21(2,36)19(32)20(35)33-12-16-7-3-13-11-14(22(37,23(26,27)28)24(29,30)31)4-10-18(13)34(16)40(38,39)17-8-5-15(25)6-9-17/h4-6,8-11,16,19,36-37H,3,7,12,32H2,1-2H3,(H,33,35)/t16-,19-/m0/s1 RRKJXSCLYRAVFY-LPHOPBHVSA-N 327777 US9663469, 325 Nuclear receptor ROR-gamma [262-507] 80.0 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327777 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327777&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117950128 384582709 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 643831 COC[C@H](N)C(=O)NC[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C23H24F7N3O5S/c1-38-12-18(31)20(34)32-11-16-6-2-13-10-14(21(35,22(25,26)27)23(28,29)30)3-9-19(13)33(16)39(36,37)17-7-4-15(24)5-8-17/h3-5,7-10,16,18,35H,2,6,11-12,31H2,1H3,(H,32,34)/t16-,18-/m0/s1 WMKWSKXEPAMUTG-WMZOPIPTSA-N 327778 US9663469, 326 Nuclear receptor ROR-gamma [262-507] 100.0 US Patent 10.7270/Q2ZS2ZN3 aid1796793 US9663469 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327778 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327778&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 117950077 384582710 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931058 Cc1ccc(cc1)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)[C@H]1CC[C@@](F)(CC1)C(O)=O InChI=1S/C30H29F8NO5S/c1-17-2-6-21(7-3-17)45(43,44)27-14-15-39(24(40)18-10-12-26(31,13-11-18)25(41)42)23(27)9-4-19-16-20(5-8-22(19)27)28(32,29(33,34)35)30(36,37)38/h2-3,5-8,16,18,23H,4,9-15H2,1H3,(H,41,42)/t18-,23?,26+,27? WPGVXUGXFMJDHZ-MJALUPOVSA-N 382247 US10273259, Example 31::US10711020, Example 31 Nuclear receptor ROR-gamma [262-507] 64.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382247 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382247&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678955 404851620 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931059 COc1ccc(cc1)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C12CCC(CC1)(CC2)C(O)=O InChI=1S/C32H32F7NO6S/c1-46-21-4-6-22(7-5-21)47(44,45)29-16-17-40(25(41)27-10-13-28(14-11-27,15-12-27)26(42)43)24(29)9-2-19-18-20(3-8-23(19)29)30(33,31(34,35)36)32(37,38)39/h3-8,18,24H,2,9-17H2,1H3,(H,42,43) WVDKLXHBJUUHGG-UHFFFAOYSA-N 382436 US10273259, Example 147::US10711020, Example 147 Nuclear receptor ROR-gamma [262-507] 250 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382436 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382436&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678600 404851805 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931060 CCOc1ccc(cc1)S(=O)(=O)C12CCCN(C1COc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C12CCC(CC1)(CC2)C(O)=O InChI=1S/C33H34F7NO7S/c1-2-47-21-5-7-22(8-6-21)49(45,46)30-10-3-17-41(26(42)28-11-14-29(15-12-28,16-13-28)27(43)44)25(30)19-48-24-18-20(4-9-23(24)30)31(34,32(35,36)37)33(38,39)40/h4-9,18,25H,2-3,10-17,19H2,1H3,(H,43,44) WBLZUSMDKVYAAZ-UHFFFAOYSA-N 382437 US10273259, Example 148::US10711020, Example 148 Nuclear receptor ROR-gamma [262-507] 442 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382437 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382437&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678908 404851806 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931061 CCOc1ccc(cc1)S(=O)(=O)C12CCCN(C1COc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)[C@H]1CC[C@@H](CC1)C(O)=O InChI=1S/C31H32F7NO7S/c1-2-45-21-9-11-22(12-10-21)47(43,44)28-14-3-15-39(26(40)18-4-6-19(7-5-18)27(41)42)25(28)17-46-24-16-20(8-13-23(24)28)29(32,30(33,34)35)31(36,37)38/h8-13,16,18-19,25H,2-7,14-15,17H2,1H3,(H,41,42)/t18-,19-,25?,28? UIBKSJWIRDQSAZ-XUNNZJKZSA-N 382438 US10273259, Example 149::US10711020, Example 149 Nuclear receptor ROR-gamma [262-507] 265 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382438 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382438&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678684 404851807 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931062 OC(=O)C1CC2(C1)CC(C2)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)Cc1ccccc1 InChI=1S/C31H30F7NO5S/c32-29(30(33,34)35,31(36,37)38)22-7-8-23-19(12-22)6-9-24-28(23,45(43,44)17-18-4-2-1-3-5-18)10-11-39(24)25(40)20-13-27(14-20)15-21(16-27)26(41)42/h1-5,7-8,12,20-21,24H,6,9-11,13-17H2,(H,41,42) URMVEXBURMYAMS-UHFFFAOYSA-N 453187 US10711020, Example 150 Nuclear receptor ROR-gamma [262-507] 11.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=453187 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=453187&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679019 440969153 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931063 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CCCC2(C1COc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C29H27F8NO6S/c30-19-7-9-20(10-8-19)45(42,43)26-12-1-13-38(24(39)16-2-4-17(5-3-16)25(40)41)23(26)15-44-22-14-18(6-11-21(22)26)27(31,28(32,33)34)29(35,36)37/h6-11,14,16-17,23H,1-5,12-13,15H2,(H,40,41)/t16-,17-,23?,26? GWCRKJLRLXBACM-LRVXPCDCSA-N 382440 US10273259, Example 151::US10711020, Example 151 Nuclear receptor ROR-gamma [262-507] 56.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382440 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382440&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678809 404851809 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931064 CCOc1ccc(cc1)S(=O)(=O)C12CCCN(C1COc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)[C@H]1CC[C@@](C)(CC1)C(O)=O InChI=1S/C32H34F7NO7S/c1-3-46-21-6-8-22(9-7-21)48(44,45)29-13-4-16-40(26(41)19-11-14-28(2,15-12-19)27(42)43)25(29)18-47-24-17-20(5-10-23(24)29)30(33,31(34,35)36)32(37,38)39/h5-10,17,19,25H,3-4,11-16,18H2,1-2H3,(H,42,43)/t19-,25?,28-,29? XOBNEYKSLOEJHF-NAOKKOESSA-N 382441 US10273259, Example 152::US10711020, Example 152 Nuclear receptor ROR-gamma [262-507] 1631 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382441 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382441&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678687 404851810 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931065 OC(=O)C12CCC(CC1)(CC2)C(=O)N1CCCC2(C1COc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C31H29F8NO6S/c32-19-3-5-20(6-4-19)47(44,45)28-8-1-15-40(24(41)26-9-12-27(13-10-26,14-11-26)25(42)43)23(28)17-46-22-16-18(2-7-21(22)28)29(33,30(34,35)36)31(37,38)39/h2-7,16,23H,1,8-15,17H2,(H,42,43) MEAXOPGVTHXMOP-UHFFFAOYSA-N 382442 US10273259, Example 153::US10711020, Example 153 Nuclear receptor ROR-gamma [262-507] 56.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382442 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382442&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678604 404851811 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931066 OC(=O)c1ccc(cc1)C(=O)N1CCC2(C1COc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H19F8NO6S/c29-18-6-8-19(9-7-18)44(41,42)25-11-12-37(23(38)15-1-3-16(4-2-15)24(39)40)22(25)14-43-21-13-17(5-10-20(21)25)26(30,27(31,32)33)28(34,35)36/h1-10,13,22H,11-12,14H2,(H,39,40) ILAQGJPMXAMLFT-UHFFFAOYSA-N 382445 US10273259, Example 154::US10711020, Example 154 Nuclear receptor ROR-gamma [262-507] 58.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382445 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382445&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678808 404851814 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931067 OC(=O)C1CC2(C1)CC(C2)C(=O)N1CCC2(C1COc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C29H25F8NO6S/c30-18-2-4-19(5-3-18)45(42,43)26-7-8-38(23(39)15-10-25(11-15)12-16(13-25)24(40)41)22(26)14-44-21-9-17(1-6-20(21)26)27(31,28(32,33)34)29(35,36)37/h1-6,9,15-16,22H,7-8,10-14H2,(H,40,41) CCTNQUKJYIYGEN-UHFFFAOYSA-N 453192 US10711020, Example 155 Nuclear receptor ROR-gamma [262-507] 40.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=453192 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=453192&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678545 440969158 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931068 OC(=O)c1ccc(cc1)C(=O)N1CCC2(C1COc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccccc1 InChI=1S/C28H20F7NO6S/c29-26(27(30,31)32,28(33,34)35)18-10-11-20-21(14-18)42-15-22-25(20,43(40,41)19-4-2-1-3-5-19)12-13-36(22)23(37)16-6-8-17(9-7-16)24(38)39/h1-11,14,22H,12-13,15H2,(H,38,39) PUDJFIKPZYXPHL-UHFFFAOYSA-N 382447 US10273259, Example 156::US10711020, Example 156 Nuclear receptor ROR-gamma [262-507] 193 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382447 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382447&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679020 404851816 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931069 OC(=O)c1ccc(cc1)C(=O)N1CC[C@]2([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C29H21F8NO5S/c30-20-7-9-21(10-8-20)44(42,43)26-13-14-38(24(39)16-1-3-17(4-2-16)25(40)41)23(26)12-5-18-15-19(6-11-22(18)26)27(31,28(32,33)34)29(35,36)37/h1-4,6-11,15,23H,5,12-14H2,(H,40,41)/t23-,26-/m0/s1 ZKAXALRFUNLGET-OZXSUGGESA-N 382448 US10273259, Example 157::US10711020, Example 157 Nuclear receptor ROR-gamma [262-507] 3562 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382448 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382448&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678910 404851817 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931070 OC(=O)C1CC2(C1)CC(C2)C(=O)N1CC[C@]2([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C30H27F8NO5S/c31-20-3-5-21(6-4-20)45(43,44)27-9-10-39(24(40)17-12-26(13-17)14-18(15-26)25(41)42)23(27)8-1-16-11-19(2-7-22(16)27)28(32,29(33,34)35)30(36,37)38/h2-7,11,17-18,23H,1,8-10,12-15H2,(H,41,42)/t17?,18?,23-,26?,27-/m0/s1 UPWOYPBEIAJQBZ-KOQJTCBRSA-N 453195 US10711020, Example 158 Nuclear receptor ROR-gamma [262-507] 6188 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=453195 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=453195&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 145995587 440969161 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931071 Cc1ccc(cc1Cl)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1CC2(CC(C2)C(O)=O)C1 InChI=1S/C31H29ClF7NO5S/c1-16-2-5-21(11-23(16)32)46(44,45)28-8-9-40(25(41)18-12-27(13-18)14-19(15-27)26(42)43)24(28)7-3-17-10-20(4-6-22(17)28)29(33,30(34,35)36)31(37,38)39/h2,4-6,10-11,18-19,24H,3,7-9,12-15H2,1H3,(H,42,43) MRQOETRHXRHSPW-UHFFFAOYSA-N 453196 US10711020, Example 159 Nuclear receptor ROR-gamma [262-507] 82.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=453196 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=453196&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 145995588 440969162 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931072 OC(=O)c1ccc(cc1)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)Cc1ccccc1 InChI=1S/C30H24F7NO5S/c31-28(29(32,33)34,30(35,36)37)22-11-12-23-21(16-22)10-13-24-27(23,44(42,43)17-18-4-2-1-3-5-18)14-15-38(24)25(39)19-6-8-20(9-7-19)26(40)41/h1-9,11-12,16,24H,10,13-15,17H2,(H,40,41) UOAMDRXYIVRQRQ-UHFFFAOYSA-N 382451 US10273259, Example 160::US10711020, Example 160 Nuclear receptor ROR-gamma [262-507] 196 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382451 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382451&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679028 404851820 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931073 OC(=O)C1CC2(C1)CC(C2)C(=O)N1CCCC2(C1COc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C30H27F8NO6S/c31-19-3-5-20(6-4-19)46(43,44)27-8-1-9-39(24(40)16-11-26(12-16)13-17(14-26)25(41)42)23(27)15-45-22-10-18(2-7-21(22)27)28(32,29(33,34)35)30(36,37)38/h2-7,10,16-17,23H,1,8-9,11-15H2,(H,41,42) AAERXBIWJSWMNS-UHFFFAOYSA-N 453198 US10711020, Example 161 Nuclear receptor ROR-gamma [262-507] 49.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=453198 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=453198&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679058 440969164 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931074 CCOc1ccc(cc1)S(=O)(=O)C12CCCN(C1COc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1CC2(CC(C2)C(O)=O)C1 InChI=1S/C32H32F7NO7S/c1-2-46-21-5-7-22(8-6-21)48(44,45)29-10-3-11-40(26(41)18-13-28(14-18)15-19(16-28)27(42)43)25(29)17-47-24-12-20(4-9-23(24)29)30(33,31(34,35)36)32(37,38)39/h4-9,12,18-19,25H,2-3,10-11,13-17H2,1H3,(H,42,43) ZOEHIFAUSJBKOJ-UHFFFAOYSA-N 453199 US10711020, Example 162 Nuclear receptor ROR-gamma [262-507] 1130 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=453199 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=453199&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678607 440969165 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931075 CCOc1ccc(cc1)S(=O)(=O)C12CCCN(C1COc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)[C@@]1(F)CC[C@@H](CC1)C(O)=O InChI=1S/C31H31F8NO7S/c1-2-46-20-5-7-21(8-6-20)48(44,45)28-12-3-15-40(26(43)27(32)13-10-18(11-14-27)25(41)42)24(28)17-47-23-16-19(4-9-22(23)28)29(33,30(34,35)36)31(37,38)39/h4-9,16,18,24H,2-3,10-15,17H2,1H3,(H,41,42)/t18-,24?,27+,28? YRSCQNBXKMEDOA-UBOLYAJWSA-N 382454 US10273259, Example 163::US10711020, Example 163 Nuclear receptor ROR-gamma [262-507] 113 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382454 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382454&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678924 404851823 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931076 OC(=O)[C@H]1CC[C@@](F)(CC1)C(=O)N1CCCC2(C1COc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C29H26F9NO6S/c30-18-3-5-19(6-4-18)46(43,44)26-10-1-13-39(24(42)25(31)11-8-16(9-12-25)23(40)41)22(26)15-45-21-14-17(2-7-20(21)26)27(32,28(33,34)35)29(36,37)38/h2-7,14,16,22H,1,8-13,15H2,(H,40,41)/t16-,22?,25+,26? MVWMLNLMDAEPAF-VXBFRIGJSA-N 382455 US10273259, Example 164::US10711020, Example 164 Nuclear receptor ROR-gamma [262-507] 231 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382455 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382455&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678810 404851824 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931077 OC(=O)C1CC2(C1)CC(C2)C(=O)N1CCC2(C1COc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccccc1 InChI=1S/C29H26F7NO6S/c30-27(28(31,32)33,29(34,35)36)18-6-7-20-21(10-18)43-15-22-26(20,44(41,42)19-4-2-1-3-5-19)8-9-37(22)23(38)16-11-25(12-16)13-17(14-25)24(39)40/h1-7,10,16-17,22H,8-9,11-15H2,(H,39,40) RVNGYUPTCMYSDI-UHFFFAOYSA-N 453202 US10711020, Example 165 Nuclear receptor ROR-gamma [262-507] 31.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=453202 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=453202&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678930 440969168 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931078 Cc1ccc(cc1)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1CC2(CC(C2)C(O)=O)C1 InChI=1S/C31H30F7NO5S/c1-17-2-6-22(7-3-17)45(43,44)28-10-11-39(25(40)19-13-27(14-19)15-20(16-27)26(41)42)24(28)9-4-18-12-21(5-8-23(18)28)29(32,30(33,34)35)31(36,37)38/h2-3,5-8,12,19-20,24H,4,9-11,13-16H2,1H3,(H,41,42) BNXFWARFAXWGKQ-UHFFFAOYSA-N 453203 US10711020, Example 166 Nuclear receptor ROR-gamma [262-507] 43.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=453203 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=453203&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678814 440969169 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931079 OC(=O)c1ccc(cc1)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(cc1)C(F)(F)F InChI=1S/C30H21F10NO5S/c31-27(29(35,36)37,30(38,39)40)20-8-11-22-18(15-20)5-12-23-26(22,47(45,46)21-9-6-19(7-10-21)28(32,33)34)13-14-41(23)24(42)16-1-3-17(4-2-16)25(43)44/h1-4,6-11,15,23H,5,12-14H2,(H,43,44) COBJQSVVZCRECX-UHFFFAOYSA-N 382458 US10273259, Example 167::US10711020, Example 167 Nuclear receptor ROR-gamma [262-507] 656 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382458 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382458&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679033 404851827 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931080 CCc1ccc(cc1)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)c1ccc(cc1)C(O)=O InChI=1S/C31H26F7NO5S/c1-2-18-3-11-23(12-4-18)45(43,44)28-15-16-39(26(40)19-5-7-20(8-6-19)27(41)42)25(28)14-9-21-17-22(10-13-24(21)28)29(32,30(33,34)35)31(36,37)38/h3-8,10-13,17,25H,2,9,14-16H2,1H3,(H,41,42) QQPSJEBSULQWPI-UHFFFAOYSA-N 382459 US10273259, Example 168::US10711020, Example 168 Nuclear receptor ROR-gamma [262-507] 184 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382459 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382459&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678929 404851828 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931081 OC(=O)C1CC2(C1)CC(C2)C(=O)N1CCC2(C1COc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C29H25F8NO6S/c30-18-2-4-19(5-3-18)45(42,43)26-7-8-38(23(39)15-10-25(11-15)12-16(13-25)24(40)41)22(26)14-44-21-9-17(1-6-20(21)26)27(31,28(32,33)34)29(35,36)37/h1-6,9,15-16,22H,7-8,10-14H2,(H,40,41) CCTNQUKJYIYGEN-UHFFFAOYSA-N 382446 US10273259, Example 155::US10711020, Example 170 Nuclear receptor ROR-gamma [262-507] 140 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382446 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382446&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678545 404851815 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931082 OC(=O)C1CC2(C1)CC(C2)C(=O)N1CCC2(C1COc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C29H25F8NO6S/c30-18-2-4-19(5-3-18)45(42,43)26-7-8-38(23(39)15-10-25(11-15)12-16(13-25)24(40)41)22(26)14-44-21-9-17(1-6-20(21)26)27(31,28(32,33)34)29(35,36)37/h1-6,9,15-16,22H,7-8,10-14H2,(H,40,41) CCTNQUKJYIYGEN-UHFFFAOYSA-N 382446 US10273259, Example 155::US10711020, Example 170 Nuclear receptor ROR-gamma [262-507] 68.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382446 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382446&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678545 404851815 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931083 Cc1ccc(cc1)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1CC2(CC(C2)C(O)=O)C1 InChI=1S/C31H30F7NO5S/c1-17-2-6-22(7-3-17)45(43,44)28-10-11-39(25(40)19-13-27(14-19)15-20(16-27)26(41)42)24(28)9-4-18-12-21(5-8-23(18)28)29(32,30(33,34)35)31(36,37)38/h2-3,5-8,12,19-20,24H,4,9-11,13-16H2,1H3,(H,41,42) BNXFWARFAXWGKQ-UHFFFAOYSA-N 382457 US10273259, Example 166::US10711020, Example 172 Nuclear receptor ROR-gamma [262-507] 256 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382457 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382457&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678814 404851826 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931084 Cc1ccc(cc1)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1CC2(CC(C2)C(O)=O)C1 InChI=1S/C31H30F7NO5S/c1-17-2-6-22(7-3-17)45(43,44)28-10-11-39(25(40)19-13-27(14-19)15-20(16-27)26(41)42)24(28)9-4-18-12-21(5-8-23(18)28)29(32,30(33,34)35)31(36,37)38/h2-3,5-8,12,19-20,24H,4,9-11,13-16H2,1H3,(H,41,42) BNXFWARFAXWGKQ-UHFFFAOYSA-N 382457 US10273259, Example 166::US10711020, Example 172 Nuclear receptor ROR-gamma [262-507] 185 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382457 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382457&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678814 404851826 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931085 OC(=O)C1CC2(C1)CC(C2)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(cc1)C(F)(F)F InChI=1S/C31H27F10NO5S/c32-28(30(36,37)38,31(39,40)41)20-4-7-22-16(11-20)1-8-23-27(22,48(46,47)21-5-2-19(3-6-21)29(33,34)35)9-10-42(23)24(43)17-12-26(13-17)14-18(15-26)25(44)45/h2-7,11,17-18,23H,1,8-10,12-15H2,(H,44,45) OREGCUCQACYGQO-UHFFFAOYSA-N 382464 US10273259, Example 173::US10711020, Example 174 Nuclear receptor ROR-gamma [262-507] 147 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382464 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382464&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 138592475 404851833 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931086 OC(=O)C1CC2(C1)CC(C2)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(cc1)C(F)(F)F InChI=1S/C31H27F10NO5S/c32-28(30(36,37)38,31(39,40)41)20-4-7-22-16(11-20)1-8-23-27(22,48(46,47)21-5-2-19(3-6-21)29(33,34)35)9-10-42(23)24(43)17-12-26(13-17)14-18(15-26)25(44)45/h2-7,11,17-18,23H,1,8-10,12-15H2,(H,44,45) OREGCUCQACYGQO-UHFFFAOYSA-N 382464 US10273259, Example 173::US10711020, Example 174 Nuclear receptor ROR-gamma [262-507] 60.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382464 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382464&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 138592475 404851833 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931087 OC(=O)C1CC2(C1)CC(C2)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccccn1 InChI=1S/C29H27F7N2O5S/c30-27(28(31,32)33,29(34,35)36)19-5-6-20-16(11-19)4-7-21-26(20,44(42,43)22-3-1-2-9-37-22)8-10-38(21)23(39)17-12-25(13-17)14-18(15-25)24(40)41/h1-3,5-6,9,11,17-18,21H,4,7-8,10,12-15H2,(H,40,41) FKJUIKKANHHJKI-UHFFFAOYSA-N 382466 US10273259, Example 175::US10711020, Example 176 Nuclear receptor ROR-gamma [262-507] 77.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382466 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382466&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 138592460 404851835 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931088 OC(=O)C1CC2(C1)CC(C2)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccccn1 InChI=1S/C29H27F7N2O5S/c30-27(28(31,32)33,29(34,35)36)19-5-6-20-16(11-19)4-7-21-26(20,44(42,43)22-3-1-2-9-37-22)8-10-38(21)23(39)17-12-25(13-17)14-18(15-25)24(40)41/h1-3,5-6,9,11,17-18,21H,4,7-8,10,12-15H2,(H,40,41) FKJUIKKANHHJKI-UHFFFAOYSA-N 382466 US10273259, Example 175::US10711020, Example 176 Nuclear receptor ROR-gamma [262-507] 70.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382466 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382466&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 138592460 404851835 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931089 CCc1ccc(cc1)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1CC2(CC(C2)C(O)=O)C1 InChI=1S/C32H32F7NO5S/c1-2-18-3-7-23(8-4-18)46(44,45)29-11-12-40(26(41)20-14-28(15-20)16-21(17-28)27(42)43)25(29)10-5-19-13-22(6-9-24(19)29)30(33,31(34,35)36)32(37,38)39/h3-4,6-9,13,20-21,25H,2,5,10-12,14-17H2,1H3,(H,42,43) ABLUPHLRENFCNH-UHFFFAOYSA-N 382468 US10273259, Example 177::US10273259, Example 178::US10711020, Example 178 Nuclear receptor ROR-gamma [262-507] 99.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382468 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382468&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 138592461 404851837 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931090 CCc1ccc(cc1)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1CC2(CC(C2)C(O)=O)C1 InChI=1S/C32H32F7NO5S/c1-2-18-3-7-23(8-4-18)46(44,45)29-11-12-40(26(41)20-14-28(15-20)16-21(17-28)27(42)43)25(29)10-5-19-13-22(6-9-24(19)29)30(33,31(34,35)36)32(37,38)39/h3-4,6-9,13,20-21,25H,2,5,10-12,14-17H2,1H3,(H,42,43) ABLUPHLRENFCNH-UHFFFAOYSA-N 382468 US10273259, Example 177::US10273259, Example 178::US10711020, Example 178 Nuclear receptor ROR-gamma [262-507] 79.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382468 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382468&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 138592461 404851837 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931091 CC1(CCS(=O)(=O)CC1)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccccn1 InChI=1S/C27H27F7N2O5S2/c1-23(10-14-42(38,39)15-11-23)22(37)36-13-9-24(43(40,41)21-4-2-3-12-35-21)19-7-6-18(16-17(19)5-8-20(24)36)25(28,26(29,30)31)27(32,33)34/h2-4,6-7,12,16,20H,5,8-11,13-15H2,1H3 QYXGXJIPIUURBV-UHFFFAOYSA-N 382470 US10273259, Example 179::US10711020, Example 179 Nuclear receptor ROR-gamma [262-507] 132 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382470 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382470&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678605 404851838 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931092 OC(=O)C1CC2(C1)CC(C2)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(Cl)cc1 InChI=1S/C30H27ClF7NO5S/c31-20-3-5-21(6-4-20)45(43,44)27-9-10-39(24(40)17-12-26(13-17)14-18(15-26)25(41)42)23(27)8-1-16-11-19(2-7-22(16)27)28(32,29(33,34)35)30(36,37)38/h2-7,11,17-18,23H,1,8-10,12-15H2,(H,41,42) RGXXEOFNVGRMPO-UHFFFAOYSA-N 382471 US10273259, Example 180::US10711020, Example 182 Nuclear receptor ROR-gamma [262-507] 35.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382471 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382471&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679078 404851839 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931093 FC(F)(F)C(F)(c1ccc2c(CCC3N(CCC23S(=O)(=O)c2ccccn2)C(=O)C2CCS(=O)(=O)CC2)c1)C(F)(F)F InChI=1S/C26H25F7N2O5S2/c27-24(25(28,29)30,26(31,32)33)18-5-6-19-17(15-18)4-7-20-23(19,42(39,40)21-3-1-2-11-34-21)10-12-35(20)22(36)16-8-13-41(37,38)14-9-16/h1-3,5-6,11,15-16,20H,4,7-10,12-14H2 GMYAHKGUKTUYTI-UHFFFAOYSA-N 382404 US10273259, Example 116::US10273259, Example 181::US10711020, Example 116 Nuclear receptor ROR-gamma [262-507] 121 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382404 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382404&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678791 404851774 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931094 OC(=O)C1CC2(C1)CC(C2)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(Cl)cc1 InChI=1S/C30H27ClF7NO5S/c31-20-3-5-21(6-4-20)45(43,44)27-9-10-39(24(40)17-12-26(13-17)14-18(15-26)25(41)42)23(27)8-1-16-11-19(2-7-22(16)27)28(32,29(33,34)35)30(36,37)38/h2-7,11,17-18,23H,1,8-10,12-15H2,(H,41,42) RGXXEOFNVGRMPO-UHFFFAOYSA-N 382471 US10273259, Example 180::US10711020, Example 182 Nuclear receptor ROR-gamma [262-507] 72.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382471 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382471&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679078 404851839 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931095 OC1(CCS(=O)(=O)CC1)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccccn1 InChI=1S/C26H25F7N2O6S2/c27-24(25(28,29)30,26(31,32)33)17-5-6-18-16(15-17)4-7-19-23(18,43(40,41)20-3-1-2-11-34-20)8-12-35(19)21(36)22(37)9-13-42(38,39)14-10-22/h1-3,5-6,11,15,19,37H,4,7-10,12-14H2 WJJYJLVRZNZANL-UHFFFAOYSA-N 382474 US10273259, Example 183::US10711020, Example 183 Nuclear receptor ROR-gamma [262-507] 37.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382474 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382474&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678691 404851841 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931096 Cc1ccc(cc1)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1CCS(=O)(=O)C1 InChI=1S/C27H26F7NO5S2/c1-16-2-6-20(7-3-16)42(39,40)24-11-12-35(23(36)18-10-13-41(37,38)15-18)22(24)9-4-17-14-19(5-8-21(17)24)25(28,26(29,30)31)27(32,33)34/h2-3,5-8,14,18,22H,4,9-13,15H2,1H3 JCZODKLTPOVXKK-UHFFFAOYSA-N 382475 US10273259, Example 184::US10711020, Example 184 Nuclear receptor ROR-gamma [262-507] 31.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382475 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382475&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 138592512 404851842 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931097 FC(F)(F)c1ccc(cc1)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1CCS(=O)(=O)C1 InChI=1S/C27H23F10NO5S2/c28-24(26(32,33)34,27(35,36)37)18-4-7-20-15(13-18)1-8-21-23(20,10-11-38(21)22(39)16-9-12-44(40,41)14-16)45(42,43)19-5-2-17(3-6-19)25(29,30)31/h2-7,13,16,21H,1,8-12,14H2 BMEFUXGXMBLNNG-UHFFFAOYSA-N 382476 US10273259, Example 185::US10711020, Example 185 Nuclear receptor ROR-gamma [262-507] 21.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382476 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382476&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 132123625 404851843 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931098 CCc1ccc(cc1)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1CCS(=O)(=O)C1 InChI=1S/C28H28F7NO5S2/c1-2-17-3-7-21(8-4-17)43(40,41)25-12-13-36(24(37)19-11-14-42(38,39)16-19)23(25)10-5-18-15-20(6-9-22(18)25)26(29,27(30,31)32)28(33,34)35/h3-4,6-9,15,19,23H,2,5,10-14,16H2,1H3 KXQQBYSAEDZSOY-UHFFFAOYSA-N 382477 US10273259, Example 186::US10711020, Example 186 Nuclear receptor ROR-gamma [262-507] 42.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382477 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382477&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679061 404851844 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931099 FC(F)(F)c1ccc(cc1)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1CCS(=O)(=O)CC1 InChI=1S/C28H25F10NO5S2/c29-25(27(33,34)35,28(36,37)38)19-4-7-21-17(15-19)1-8-22-24(21,46(43,44)20-5-2-18(3-6-20)26(30,31)32)11-12-39(22)23(40)16-9-13-45(41,42)14-10-16/h2-7,15-16,22H,1,8-14H2 NMJDADYOTDMQRM-UHFFFAOYSA-N 382478 US10273259, Example 187::US10711020, Example 187 Nuclear receptor ROR-gamma [262-507] 43.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382478 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382478&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678694 404851845 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931100 FC(F)(F)C(F)(c1ccc2c(CCC3N(CCC23S(=O)(=O)c2ccccn2)C(=O)C2CCS(=O)(=O)C2)c1)C(F)(F)F InChI=1S/C25H23F7N2O5S2/c26-23(24(27,28)29,25(30,31)32)17-5-6-18-15(13-17)4-7-19-22(18,41(38,39)20-3-1-2-10-33-20)9-11-34(19)21(35)16-8-12-40(36,37)14-16/h1-3,5-6,10,13,16,19H,4,7-9,11-12,14H2 MJHVPJDIGHIQDH-UHFFFAOYSA-N 382479 US10273259, Example 188::US10711020, Example 188 Nuclear receptor ROR-gamma [262-507] 63.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382479 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382479&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678696 404851846 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931101 OC1(CCS(=O)(=O)CC1)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(Cl)cc1 InChI=1S/C27H25ClF7NO6S2/c28-18-3-5-19(6-4-18)44(41,42)24-9-12-36(22(37)23(38)10-13-43(39,40)14-11-23)21(24)8-1-16-15-17(2-7-20(16)24)25(29,26(30,31)32)27(33,34)35/h2-7,15,21,38H,1,8-14H2 QYPYNJHEHYAJCO-UHFFFAOYSA-N 382480 US10273259, Example 189::US10711020, Example 189 Nuclear receptor ROR-gamma [262-507] 41.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382480 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382480&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679044 404851847 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931102 CC1(CCS(=O)(=O)CC1)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(Cl)cc1 InChI=1S/C28H27ClF7NO5S2/c1-24(11-14-43(39,40)15-12-24)23(38)37-13-10-25(44(41,42)20-6-4-19(29)5-7-20)21-8-3-18(16-17(21)2-9-22(25)37)26(30,27(31,32)33)28(34,35)36/h3-8,16,22H,2,9-15H2,1H3 IKMGSFDIFWQQER-UHFFFAOYSA-N 382481 US10273259, Example 190::US10711020, Example 190 Nuclear receptor ROR-gamma [262-507] 20.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382481 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382481&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678702 404851848 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931103 FC(F)(F)C(F)(c1ccc2c(CCC3N(CCC23S(=O)(=O)c2ccc(Cl)cc2)C(=O)C2CCS(=O)(=O)C2)c1)C(F)(F)F InChI=1S/C26H23ClF7NO5S2/c27-18-3-5-19(6-4-18)42(39,40)23-10-11-35(22(36)16-9-12-41(37,38)14-16)21(23)8-1-15-13-17(2-7-20(15)23)24(28,25(29,30)31)26(32,33)34/h2-7,13,16,21H,1,8-12,14H2 MXSYEHXMCRTPGX-UHFFFAOYSA-N 382483 US10273259, Example 192::US10273259, Example 193::US10711020, Example 193 Nuclear receptor ROR-gamma [262-507] 9.00 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382483 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382483&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678606 404851850 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931104 FC(F)(F)C(F)(c1ccc2c(CCC3N(CCC23S(=O)(=O)c2ccc(Cl)cc2)C(=O)C2CCS(=O)(=O)C2)c1)C(F)(F)F InChI=1S/C26H23ClF7NO5S2/c27-18-3-5-19(6-4-18)42(39,40)23-10-11-35(22(36)16-9-12-41(37,38)14-16)21(23)8-1-15-13-17(2-7-20(15)23)24(28,25(29,30)31)26(32,33)34/h2-7,13,16,21H,1,8-12,14H2 MXSYEHXMCRTPGX-UHFFFAOYSA-N 382483 US10273259, Example 192::US10273259, Example 193::US10711020, Example 193 Nuclear receptor ROR-gamma [262-507] 21.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382483 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382483&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678606 404851850 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931105 FC(F)(F)C(F)(c1ccc2c(CCC3N(CCC23S(=O)(=O)c2ccc(Cl)cc2)C(=O)C2CCS(=O)(=O)C2)c1)C(F)(F)F InChI=1S/C26H23ClF7NO5S2/c27-18-3-5-19(6-4-18)42(39,40)23-10-11-35(22(36)16-9-12-41(37,38)14-16)21(23)8-1-15-13-17(2-7-20(15)23)24(28,25(29,30)31)26(32,33)34/h2-7,13,16,21H,1,8-12,14H2 MXSYEHXMCRTPGX-UHFFFAOYSA-N 382483 US10273259, Example 192::US10273259, Example 193::US10711020, Example 193 Nuclear receptor ROR-gamma [262-507] 21.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382483 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382483&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678606 404851850 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931106 CC(C)N1[C@@H](CCC1=O)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C29H28F8N2O4S/c1-16(2)39-22(10-12-24(39)40)25(41)38-14-13-26(44(42,43)20-7-5-19(30)6-8-20)21-9-4-18(15-17(21)3-11-23(26)38)27(31,28(32,33)34)29(35,36)37/h4-9,15-16,22-23H,3,10-14H2,1-2H3/t22-,23?,26?/m0/s1 KFUALJWIARVOTP-MFNHVEPQSA-N 382485 US10273259, Example 194::US10711020, Example 194 Nuclear receptor ROR-gamma [262-507] 162 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382485 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382485&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678936 404851851 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931107 Cc1cccc(c1)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)[C@H]1CC[C@@H](CC1)C(O)=O InChI=1S/C30H30F7NO5S/c1-17-3-2-4-22(15-17)44(42,43)27-13-14-38(25(39)18-5-7-19(8-6-18)26(40)41)24(27)12-9-20-16-21(10-11-23(20)27)28(31,29(32,33)34)30(35,36)37/h2-4,10-11,15-16,18-19,24H,5-9,12-14H2,1H3,(H,40,41)/t18-,19-,24?,27? UCLOLQONKUCIPI-QXIWJBPRSA-N 382486 US10273259, Example 195::US10711020, Example 195 Nuclear receptor ROR-gamma [262-507] 49.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382486 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382486&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 132123482 404851852 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931108 Cc1cccc(c1)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C12CCC(CC1)(CC2)C(O)=O InChI=1S/C32H32F7NO5S/c1-19-3-2-4-22(17-19)46(44,45)29-15-16-40(25(41)27-9-12-28(13-10-27,14-11-27)26(42)43)24(29)8-5-20-18-21(6-7-23(20)29)30(33,31(34,35)36)32(37,38)39/h2-4,6-7,17-18,24H,5,8-16H2,1H3,(H,42,43) PZMOQFDJYDGCBV-UHFFFAOYSA-N 382487 US10273259, Example 196::US10711020, Example 196 Nuclear receptor ROR-gamma [262-507] 43.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382487 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382487&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 132123502 404851853 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931109 Cc1cccc(c1)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)[C@@H]1CCC(=O)N1Cc1ccc(cc1)C#N InChI=1S/C35H30F7N3O4S/c1-21-3-2-4-26(17-21)50(48,49)32-15-16-44(31(47)28-12-14-30(46)45(28)20-23-7-5-22(19-43)6-8-23)29(32)13-9-24-18-25(10-11-27(24)32)33(36,34(37,38)39)35(40,41)42/h2-8,10-11,17-18,28-29H,9,12-16,20H2,1H3/t28-,29?,32?/m0/s1 RTPQBZCQABROSE-SLIGCLJVSA-N 382488 US10273259, Example 197::US10711020, Example 197 Nuclear receptor ROR-gamma [262-507] 40.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382488 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382488&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 132123727 404851854 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931110 CN1[C@@H](CCC1=O)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1cccc(C)c1 InChI=1S/C28H27F7N2O4S/c1-16-4-3-5-19(14-16)42(40,41)25-12-13-37(24(39)21-9-11-23(38)36(21)2)22(25)10-6-17-15-18(7-8-20(17)25)26(29,27(30,31)32)28(33,34)35/h3-5,7-8,14-15,21-22H,6,9-13H2,1-2H3/t21-,22?,25?/m0/s1 MVLVBWCMWKBUDK-LBXYRFPKSA-N 382489 US10273259, Example 198::US10273259, Example 199::US10711020, Example 199 Nuclear receptor ROR-gamma [262-507] 45.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382489 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382489&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678701 404851855 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931111 CN1[C@@H](CCC1=O)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1cccc(C)c1 InChI=1S/C28H27F7N2O4S/c1-16-4-3-5-19(14-16)42(40,41)25-12-13-37(24(39)21-9-11-23(38)36(21)2)22(25)10-6-17-15-18(7-8-20(17)25)26(29,27(30,31)32)28(33,34)35/h3-5,7-8,14-15,21-22H,6,9-13H2,1-2H3/t21-,22?,25?/m0/s1 MVLVBWCMWKBUDK-LBXYRFPKSA-N 382489 US10273259, Example 198::US10273259, Example 199::US10711020, Example 199 Nuclear receptor ROR-gamma [262-507] 41.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382489 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382489&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678701 404851855 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931112 Cc1cccc(c1)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1CCS(=O)(=O)CC1 InChI=1S/C28H28F7NO5S2/c1-17-3-2-4-21(15-17)43(40,41)25-11-12-36(24(37)18-9-13-42(38,39)14-10-18)23(25)8-5-19-16-20(6-7-22(19)25)26(29,27(30,31)32)28(33,34)35/h2-4,6-7,15-16,18,23H,5,8-14H2,1H3 BZYBMICTADZPGU-UHFFFAOYSA-N 382491 US10273259, Example 200::US10711020, Example 200 Nuclear receptor ROR-gamma [262-507] 143 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382491 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382491&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 132123481 404851856 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931113 Cc1cccc(c1)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1(C)CCS(=O)(=O)CC1 InChI=1S/C29H30F7NO5S2/c1-18-4-3-5-21(16-18)44(41,42)26-10-13-37(24(38)25(2)11-14-43(39,40)15-12-25)23(26)9-6-19-17-20(7-8-22(19)26)27(30,28(31,32)33)29(34,35)36/h3-5,7-8,16-17,23H,6,9-15H2,1-2H3 XOJBDZKNWQXWLC-UHFFFAOYSA-N 382492 US10273259, Example 201::US10711020, Example 201 Nuclear receptor ROR-gamma [262-507] 141 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382492 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382492&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 132123503 404851857 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931114 Cc1cccc(c1)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1(O)CCC(CC1)C(O)=O InChI=1S/C30H30F7NO6S/c1-17-3-2-4-21(15-17)45(43,44)27-13-14-38(25(41)26(42)11-9-18(10-12-26)24(39)40)23(27)8-5-19-16-20(6-7-22(19)27)28(31,29(32,33)34)30(35,36)37/h2-4,6-7,15-16,18,23,42H,5,8-14H2,1H3,(H,39,40) SIEJUYOUEAJNOR-UHFFFAOYSA-N 382493 US10273259, Example 202::US10711020, Example 202 Nuclear receptor ROR-gamma [262-507] 204 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382493 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382493&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 132123505 404851858 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931115 Cc1cccc(c1)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)[C@@]1(C)CC[C@@H](CC1)C(O)=O InChI=1S/C31H32F7NO5S/c1-18-4-3-5-22(16-18)45(43,44)28-14-15-39(26(42)27(2)12-10-19(11-13-27)25(40)41)24(28)9-6-20-17-21(7-8-23(20)28)29(32,30(33,34)35)31(36,37)38/h3-5,7-8,16-17,19,24H,6,9-15H2,1-2H3,(H,40,41)/t19-,24?,27-,28? YLTAZSBNSYXNGO-XJNMGFQWSA-N 382494 US10273259, Example 203::US10711020, Example 203 Nuclear receptor ROR-gamma [262-507] 68.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382494 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382494&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 132123504 404851859 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931116 Cc1cccc(c1)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)CC(C)(C)O InChI=1S/C27H28F7NO4S/c1-16-5-4-6-19(13-16)40(38,39)24-11-12-35(22(36)15-23(2,3)37)21(24)10-7-17-14-18(8-9-20(17)24)25(28,26(29,30)31)27(32,33)34/h4-6,8-9,13-14,21,37H,7,10-12,15H2,1-3H3 PFYZSCUZQWTTQR-UHFFFAOYSA-N 382495 US10273259, Example 204::US10711020, Example 204 Nuclear receptor ROR-gamma [262-507] 79.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382495 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382495&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122680844 404851860 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931117 Fc1cccc(c1)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)[C@@H]1CCC(=O)N1Cc1ccc(cc1)C#N InChI=1S/C34H27F8N3O4S/c35-24-2-1-3-25(17-24)50(48,49)31-14-15-44(30(47)27-11-13-29(46)45(27)19-21-6-4-20(18-43)5-7-21)28(31)12-8-22-16-23(9-10-26(22)31)32(36,33(37,38)39)34(40,41)42/h1-7,9-10,16-17,27-28H,8,11-15,19H2/t27-,28?,31?/m0/s1 FAXVEERWTHXMMC-XFXVWLJXSA-N 382496 US10273259, Example 205::US10711020, Example 205 Nuclear receptor ROR-gamma [262-507] 136 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382496 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382496&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 132123831 404851861 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931118 CN1[C@@H](CCC1=O)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1cccc(F)c1 InChI=1S/C27H24F8N2O4S/c1-36-20(8-10-22(36)38)23(39)37-12-11-24(42(40,41)18-4-2-3-17(28)14-18)19-7-6-16(13-15(19)5-9-21(24)37)25(29,26(30,31)32)27(33,34)35/h2-4,6-7,13-14,20-21H,5,8-12H2,1H3/t20-,21?,24?/m0/s1 JPICNJJDAWWROI-MFMCRYCZSA-N 382497 US10273259, Example 206::US10273259, Example 207::US10711020, Example 207 Nuclear receptor ROR-gamma [262-507] 59.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382497 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382497&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679029 404851862 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931119 CN1[C@@H](CCC1=O)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1cccc(F)c1 InChI=1S/C27H24F8N2O4S/c1-36-20(8-10-22(36)38)23(39)37-12-11-24(42(40,41)18-4-2-3-17(28)14-18)19-7-6-16(13-15(19)5-9-21(24)37)25(29,26(30,31)32)27(33,34)35/h2-4,6-7,13-14,20-21H,5,8-12H2,1H3/t20-,21?,24?/m0/s1 JPICNJJDAWWROI-MFMCRYCZSA-N 382497 US10273259, Example 206::US10273259, Example 207::US10711020, Example 207 Nuclear receptor ROR-gamma [262-507] 54.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382497 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382497&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679029 404851862 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931120 FC(F)(F)C(F)(c1ccc2c(CCC3N(CCC23S(=O)(=O)c2cccc(Cl)c2)C(=O)C2CCS(=O)(=O)CC2)c1)C(F)(F)F InChI=1S/C27H25ClF7NO5S2/c28-19-2-1-3-20(15-19)43(40,41)24-10-11-36(23(37)16-8-12-42(38,39)13-9-16)22(24)7-4-17-14-18(5-6-21(17)24)25(29,26(30,31)32)27(33,34)35/h1-3,5-6,14-16,22H,4,7-13H2 CUKKBZSRYISQBH-UHFFFAOYSA-N 382499 US10273259, Example 208::US10711020, Example 208 Nuclear receptor ROR-gamma [262-507] 38.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382499 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382499&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678937 404851863 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931121 OC(=O)[C@H]1CC[C@@](O)(CC1)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1cccc(Cl)c1 InChI=1S/C29H27ClF7NO6S/c30-19-2-1-3-20(15-19)45(43,44)26-12-13-38(24(41)25(42)10-8-16(9-11-25)23(39)40)22(26)7-4-17-14-18(5-6-21(17)26)27(31,28(32,33)34)29(35,36)37/h1-3,5-6,14-16,22,42H,4,7-13H2,(H,39,40)/t16-,22?,25+,26? OWQNPYOBRQKKOE-VXBFRIGJSA-N 382500 US10273259, Example 209::US10711020, Example 209 Nuclear receptor ROR-gamma [262-507] 123 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382500 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382500&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678816 404851864 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931122 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1cccc(Cl)c1 InChI=1S/C29H27ClF7NO5S/c30-20-2-1-3-21(15-20)44(42,43)26-12-13-38(24(39)16-4-6-17(7-5-16)25(40)41)23(26)11-8-18-14-19(9-10-22(18)26)27(31,28(32,33)34)29(35,36)37/h1-3,9-10,14-17,23H,4-8,11-13H2,(H,40,41)/t16-,17-,23?,26? CFTRQLKAHBITQD-LRVXPCDCSA-N 382501 US10273259, Example 210::US10711020, Example 210 Nuclear receptor ROR-gamma [262-507] 24.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382501 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382501&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678941 404851865 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931123 OC(=O)C12CCC(CC1)(CC2)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1cccc(Cl)c1 InChI=1S/C31H29ClF7NO5S/c32-20-2-1-3-21(17-20)46(44,45)28-14-15-40(24(41)26-8-11-27(12-9-26,13-10-26)25(42)43)23(28)7-4-18-16-19(5-6-22(18)28)29(33,30(34,35)36)31(37,38)39/h1-3,5-6,16-17,23H,4,7-15H2,(H,42,43) YAPKXGXXZUYCIH-UHFFFAOYSA-N 382502 US10273259, Example 211::US10711020, Example 211 Nuclear receptor ROR-gamma [262-507] 22.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382502 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382502&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678707 404851866 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931124 CN1[C@@H](CCC1=O)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1cccc(Cl)c1 InChI=1S/C27H24ClF7N2O4S/c1-36-20(8-10-22(36)38)23(39)37-12-11-24(42(40,41)18-4-2-3-17(28)14-18)19-7-6-16(13-15(19)5-9-21(24)37)25(29,26(30,31)32)27(33,34)35/h2-4,6-7,13-14,20-21H,5,8-12H2,1H3/t20-,21?,24?/m0/s1 MIZXAOSVPMWBEM-MFMCRYCZSA-N 382503 US10273259, Example 212::US10273259, Example 213::US10711020, Example 213 Nuclear receptor ROR-gamma [262-507] 22.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382503 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382503&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678817 404851867 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931125 CN1[C@@H](CCC1=O)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1cccc(Cl)c1 InChI=1S/C27H24ClF7N2O4S/c1-36-20(8-10-22(36)38)23(39)37-12-11-24(42(40,41)18-4-2-3-17(28)14-18)19-7-6-16(13-15(19)5-9-21(24)37)25(29,26(30,31)32)27(33,34)35/h2-4,6-7,13-14,20-21H,5,8-12H2,1H3/t20-,21?,24?/m0/s1 MIZXAOSVPMWBEM-MFMCRYCZSA-N 382503 US10273259, Example 212::US10273259, Example 213::US10711020, Example 213 Nuclear receptor ROR-gamma [262-507] 97.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382503 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382503&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678817 404851867 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931126 FC(F)(F)C(F)(c1ccc2c(CCC3N(CCC23S(=O)(=O)c2cccc(Cl)c2)C(=O)[C@@H]2CCC(=O)N2Cc2ccc(cc2)C#N)c1)C(F)(F)F InChI=1S/C34H27ClF7N3O4S/c35-24-2-1-3-25(17-24)50(48,49)31-14-15-44(30(47)27-11-13-29(46)45(27)19-21-6-4-20(18-43)5-7-21)28(31)12-8-22-16-23(9-10-26(22)31)32(36,33(37,38)39)34(40,41)42/h1-7,9-10,16-17,27-28H,8,11-15,19H2/t27-,28?,31?/m0/s1 SHLJQZILEURESG-XFXVWLJXSA-N 382505 US10273259, Example 214::US10711020, Example 214 Nuclear receptor ROR-gamma [262-507] 64.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382505 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382505&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679026 404851868 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931127 OC(=O)[C@H]1CC[C@@](F)(CC1)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1cccc(Cl)c1 InChI=1S/C29H26ClF8NO5S/c30-19-2-1-3-20(15-19)45(43,44)26-12-13-39(24(42)25(31)10-8-16(9-11-25)23(40)41)22(26)7-4-17-14-18(5-6-21(17)26)27(32,28(33,34)35)29(36,37)38/h1-3,5-6,14-16,22H,4,7-13H2,(H,40,41)/t16-,22?,25+,26? BFEDNCMUXBBKEB-VXBFRIGJSA-N 382506 US10273259, Example 215::US10711020, Example 215 Nuclear receptor ROR-gamma [262-507] 92.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382506 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382506&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678456 404851869 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931128 OC(=O)[C@@]1(F)CC[C@@H](CC1)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1cccc(Cl)c1 InChI=1S/C29H26ClF8NO5S/c30-19-2-1-3-20(15-19)45(43,44)26-12-13-39(23(40)16-8-10-25(31,11-9-16)24(41)42)22(26)7-4-17-14-18(5-6-21(17)26)27(32,28(33,34)35)29(36,37)38/h1-3,5-6,14-16,22H,4,7-13H2,(H,41,42)/t16-,22?,25+,26? FTJWEFHBTUWKLO-VXBFRIGJSA-N 382507 US10273259, Example 216::US10711020, Example 216 Nuclear receptor ROR-gamma [262-507] 111 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382507 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382507&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678429 404851870 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931129 Cc1cccc(c1)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)[C@@]1(F)CC[C@@H](CC1)C(O)=O InChI=1S/C30H29F8NO5S/c1-17-3-2-4-21(15-17)45(43,44)27-13-14-39(25(42)26(31)11-9-18(10-12-26)24(40)41)23(27)8-5-19-16-20(6-7-22(19)27)28(32,29(33,34)35)30(36,37)38/h2-4,6-7,15-16,18,23H,5,8-14H2,1H3,(H,40,41)/t18-,23?,26+,27? RIZHVHAYTAMLNT-MJALUPOVSA-N 382508 US10273259, Example 217::US10711020, Example 217 Nuclear receptor ROR-gamma [262-507] 95.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382508 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382508&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 132123778 404851871 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931130 C[C@@]1(CC[C@@H](CC1)C(O)=O)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1cccc(Cl)c1 InChI=1S/C30H29ClF7NO5S/c1-26(11-9-17(10-12-26)24(40)41)25(42)39-14-13-27(45(43,44)21-4-2-3-20(31)16-21)22-7-6-19(15-18(22)5-8-23(27)39)28(32,29(33,34)35)30(36,37)38/h2-4,6-7,15-17,23H,5,8-14H2,1H3,(H,40,41)/t17-,23?,26-,27? NCIMWYXTFMBJEU-PYPIJRSMSA-N 382509 US10273259, Example 218::US10711020, Example 218 Nuclear receptor ROR-gamma [262-507] 216 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382509 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382509&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678542 404851872 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931131 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)[C@@H]1CCC(=O)N1Cc1ccc(cc1)C#N InChI=1S/C34H27F8N3O4S/c35-24-7-9-25(10-8-24)50(48,49)31-15-16-44(30(47)27-12-14-29(46)45(27)19-21-3-1-20(18-43)2-4-21)28(31)13-5-22-17-23(6-11-26(22)31)32(36,33(37,38)39)34(40,41)42/h1-4,6-11,17,27-28H,5,12-16,19H2/t27-,28+,31+/m0/s1 LUUKHFWCCAZXEK-WTNLLYQRSA-N 382510 US10273259, Example 219::US10711020, Example 219 Nuclear receptor ROR-gamma [262-507] 135 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382510 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382510&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679035 404851873 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931132 CN1[C@@H](CCC1=O)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C27H24F8N2O4S/c1-36-20(9-11-22(36)38)23(39)37-13-12-24(42(40,41)18-6-4-17(28)5-7-18)19-8-3-16(14-15(19)2-10-21(24)37)25(29,26(30,31)32)27(33,34)35/h3-8,14,20-21H,2,9-13H2,1H3/t20-,21+,24+/m0/s1 SWQNFSBHLVEMAL-YZUZCNPQSA-N 382511 US10273259, Example 220::US10273259, Example 222::US10711020, Example 222 Nuclear receptor ROR-gamma [262-507] 31.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382511 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382511&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678945 404851874 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931133 CC(C)(O)CC(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C26H25F8NO4S/c1-22(2,37)14-21(36)35-12-11-23(40(38,39)18-7-5-17(27)6-8-18)19-9-4-16(13-15(19)3-10-20(23)35)24(28,25(29,30)31)26(32,33)34/h4-9,13,20,37H,3,10-12,14H2,1-2H3/t20-,23-/m1/s1 FAZFPWKELKKKPT-NFBKMPQASA-N 382512 US10273259, Example 221::US10711020, Example 221 Nuclear receptor ROR-gamma [262-507] 27.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382512 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382512&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678819 404851875 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931134 CN1[C@@H](CCC1=O)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C27H24F8N2O4S/c1-36-20(9-11-22(36)38)23(39)37-13-12-24(42(40,41)18-6-4-17(28)5-7-18)19-8-3-16(14-15(19)2-10-21(24)37)25(29,26(30,31)32)27(33,34)35/h3-8,14,20-21H,2,9-13H2,1H3/t20-,21+,24+/m0/s1 SWQNFSBHLVEMAL-YZUZCNPQSA-N 382511 US10273259, Example 220::US10273259, Example 222::US10711020, Example 222 Nuclear receptor ROR-gamma [262-507] 30.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382511 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382511&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678945 404851874 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931135 CCN1[C@@H](CCC1=O)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H26F8N2O4S/c1-2-37-21(10-12-23(37)39)24(40)38-14-13-25(43(41,42)19-7-5-18(29)6-8-19)20-9-4-17(15-16(20)3-11-22(25)38)26(30,27(31,32)33)28(34,35)36/h4-9,15,21-22H,2-3,10-14H2,1H3/t21-,22+,25+/m0/s1 LTSZYGRBVCICKD-SGIRGMQISA-N 382514 US10273259, Example 223::US10711020, Example 223 Nuclear receptor ROR-gamma [262-507] 58.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382514 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382514&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678617 404851876 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931136 Fc1ccc(CN2[C@@H](CCC2=O)C(=O)N2CC[C@@]3([C@H]2CCc2cc(ccc32)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c2ccc(F)cc2)cc1 InChI=1S/C33H27F9N2O4S/c34-22-5-1-19(2-6-22)18-44-26(12-14-28(44)45)29(46)43-16-15-30(49(47,48)24-9-7-23(35)8-10-24)25-11-4-21(17-20(25)3-13-27(30)43)31(36,32(37,38)39)33(40,41)42/h1-2,4-11,17,26-27H,3,12-16,18H2/t26-,27+,30+/m0/s1 VEVVQCYACXKTGP-PVTPYKNESA-N 382515 US10273259, Example 224::US10711020, Example 224 Nuclear receptor ROR-gamma [262-507] 129 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382515 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382515&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678614 404851877 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931137 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)Cc1ccnnc1 InChI=1S/C27H21F8N3O3S/c28-19-3-5-20(6-4-19)42(40,41)24-10-12-38(23(39)13-16-9-11-36-37-15-16)22(24)8-1-17-14-18(2-7-21(17)24)25(29,26(30,31)32)27(33,34)35/h2-7,9,11,14-15,22H,1,8,10,12-13H2/t22-,24-/m1/s1 PTUBSSJVFTVOLU-ISKFKSNPSA-N 382516 US10273259, Example 225::US10711020, Example 225 Nuclear receptor ROR-gamma [262-507] 114 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382516 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382516&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678609 404851878 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931138 FC(F)(F)C(F)(c1ccc2c(CCC3N(CCC23S(=O)(=O)c2cccc(Cl)c2)C(=O)Cc2ccnnc2)c1)C(F)(F)F InChI=1S/C27H21ClF7N3O3S/c28-19-2-1-3-20(14-19)42(40,41)24-9-11-38(23(39)12-16-8-10-36-37-15-16)22(24)7-4-17-13-18(5-6-21(17)24)25(29,26(30,31)32)27(33,34)35/h1-3,5-6,8,10,13-15,22H,4,7,9,11-12H2 RCBBIBUSYNZLMW-UHFFFAOYSA-N 382517 US10273259, Example 226::US10711020, Example 226 Nuclear receptor ROR-gamma [262-507] 145 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382517 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382517&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678946 404851879 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931139 CC(C)(O)[C@H]1CC[C@@H](CC1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C31H33F8NO4S/c1-27(2,42)20-6-3-18(4-7-20)26(41)40-16-15-28(45(43,44)23-11-9-22(32)10-12-23)24-13-8-21(17-19(24)5-14-25(28)40)29(33,30(34,35)36)31(37,38)39/h8-13,17-18,20,25,42H,3-7,14-16H2,1-2H3/t18-,20-,25-,28-/m1/s1 IBDGDPWJUBUPMH-CVODSWBYSA-N 382518 US10273259, Example 227::US10711020, Example 227 Nuclear receptor ROR-gamma [262-507] 137 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382518 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382518&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679049 404851880 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931140 CC(C)(O)C12CCC(CC1)(CC2)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C33H35F8NO4S/c1-27(2,44)29-14-11-28(12-15-29,13-16-29)26(43)42-18-17-30(47(45,46)23-7-5-22(34)6-8-23)24-9-4-21(19-20(24)3-10-25(30)42)31(35,32(36,37)38)33(39,40)41/h4-9,19,25,44H,3,10-18H2,1-2H3/t25-,28?,29?,30-/m1/s1 CDRGPHDRUUQNEB-SBIUAKNBSA-N 382519 US10273259, Example 228::US10711020, Example 228 Nuclear receptor ROR-gamma [262-507] 464 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382519 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382519&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678610 404851881 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931141 OC(=O)c1cc([nH]n1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 382520 US10273259, Example 229::US10711020, Example 229 Nuclear receptor ROR-gamma [262-507] 56.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382520 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382520&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678622 404851882 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931142 CN1[C@@H](C[C@@H](F)C1=O)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C27H23F9N2O4S/c1-37-20(13-19(29)22(37)39)23(40)38-11-10-24(43(41,42)17-6-4-16(28)5-7-17)18-8-3-15(12-14(18)2-9-21(24)38)25(30,26(31,32)33)27(34,35)36/h3-8,12,19-21H,2,9-11,13H2,1H3/t19-,20+,21-,24-/m1/s1 PDJZLHFYLDTXLV-OOICKAIWSA-N 382521 US10273259, Example 230::US10711020, Example 230 Nuclear receptor ROR-gamma [262-507] 175 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382521 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382521&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 145995590 404851883 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931143 CN1[C@@H](C[C@H](F)C1=O)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C27H23F9N2O4S/c1-37-20(13-19(29)22(37)39)23(40)38-11-10-24(43(41,42)17-6-4-16(28)5-7-17)18-8-3-15(12-14(18)2-9-21(24)38)25(30,26(31,32)33)27(34,35)36/h3-8,12,19-21H,2,9-11,13H2,1H3/t19-,20-,21+,24+/m0/s1 PDJZLHFYLDTXLV-VMIIQTFKSA-N 382522 US10273259, Example 231::US10273259, Example 243::US10711020, Example 243 Nuclear receptor ROR-gamma [262-507] 68.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382522 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382522&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678541 404851884 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931144 CN1[C@@H](CC(F)(F)C1=O)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C27H22F10N2O4S/c1-38-19(13-24(29,30)22(38)41)21(40)39-11-10-23(44(42,43)17-6-4-16(28)5-7-17)18-8-3-15(12-14(18)2-9-20(23)39)25(31,26(32,33)34)27(35,36)37/h3-8,12,19-20H,2,9-11,13H2,1H3/t19-,20+,23+/m0/s1 UENBCEQAMCZVQL-MIZPHKNDSA-N 382523 US10273259, Example 232::US10711020, Example 232 Nuclear receptor ROR-gamma [262-507] 174 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382523 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382523&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 145995591 404851885 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931145 CN1[C@@H](C[C@H](F)C1=O)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(Cl)cc1 InChI=1S/C27H23ClF8N2O4S/c1-37-20(13-19(29)22(37)39)23(40)38-11-10-24(43(41,42)17-6-4-16(28)5-7-17)18-8-3-15(12-14(18)2-9-21(24)38)25(30,26(31,32)33)27(34,35)36/h3-8,12,19-21H,2,9-11,13H2,1H3/t19-,20-,21?,24?/m0/s1 MGBSTZNMVHLPCT-SZYSUKIFSA-N 382524 US10273259, Example 233::US10711020, Example 233 Nuclear receptor ROR-gamma [262-507] 45.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382524 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382524&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 145995592 404851886 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931146 CN1[C@@H](CC(F)(F)C1=O)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(Cl)cc1 InChI=1S/C27H22ClF9N2O4S/c1-38-19(13-24(29,30)22(38)41)21(40)39-11-10-23(44(42,43)17-6-4-16(28)5-7-17)18-8-3-15(12-14(18)2-9-20(23)39)25(31,26(32,33)34)27(35,36)37/h3-8,12,19-20H,2,9-11,13H2,1H3/t19-,20?,23?/m0/s1 WITOGCPDCBASFX-UDTLNKQYSA-N 382525 US10273259, Example 234::US10711020, Example 234 Nuclear receptor ROR-gamma [262-507] 283 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382525 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382525&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 145995593 404851887 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931147 CN1[C@@H](C[C@H](F)C1=O)C(=O)N1CCC2(C1COc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccccc1 InChI=1S/C26H22F8N2O5S/c1-35-18(12-17(27)21(35)37)22(38)36-10-9-23(42(39,40)15-5-3-2-4-6-15)16-8-7-14(11-19(16)41-13-20(23)36)24(28,25(29,30)31)26(32,33)34/h2-8,11,17-18,20H,9-10,12-13H2,1H3/t17-,18-,20?,23?/m0/s1 SEMYZRMHEFTJLB-NEPPSICNSA-N 382526 US10273259, Example 235::US10711020, Example 235 Nuclear receptor ROR-gamma [262-507] 53.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382526 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382526&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 145995594 404851888 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931148 CN1[C@@H](C[C@H](F)C1=O)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccccc1 InChI=1S/C27H24F8N2O4S/c1-36-20(14-19(28)22(36)38)23(39)37-12-11-24(42(40,41)17-5-3-2-4-6-17)18-9-8-16(13-15(18)7-10-21(24)37)25(29,26(30,31)32)27(33,34)35/h2-6,8-9,13,19-21H,7,10-12,14H2,1H3/t19-,20-,21+,24+/m0/s1 PEYOSKFVXLWXDJ-VMIIQTFKSA-N 382527 US10273259, Example 236::US10711020, Example 236 Nuclear receptor ROR-gamma [262-507] 39.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382527 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382527&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 145995595 404851889 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931149 CN1[C@@H](C[C@H](F)C1=O)C(=O)N1CCC2(C1COc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C26H21F9N2O5S/c1-36-18(11-17(28)21(36)38)22(39)37-9-8-23(43(40,41)15-5-3-14(27)4-6-15)16-7-2-13(10-19(16)42-12-20(23)37)24(29,25(30,31)32)26(33,34)35/h2-7,10,17-18,20H,8-9,11-12H2,1H3/t17-,18-,20?,23?/m0/s1 AAGXBENZSYRCQC-NEPPSICNSA-N 382528 US10273259, Example 237::US10711020, Example 237 Nuclear receptor ROR-gamma [262-507] 42.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382528 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382528&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 145995596 404851890 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931150 CN1[C@@H](C[C@H](F)C1=O)C(=O)N1CCC2(C1COc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(Cl)cc1 InChI=1S/C26H21ClF8N2O5S/c1-36-18(11-17(28)21(36)38)22(39)37-9-8-23(43(40,41)15-5-3-14(27)4-6-15)16-7-2-13(10-19(16)42-12-20(23)37)24(29,25(30,31)32)26(33,34)35/h2-7,10,17-18,20H,8-9,11-12H2,1H3/t17-,18-,20?,23?/m0/s1 ROGCQVPPXUJQNA-NEPPSICNSA-N 382529 US10273259, Example 238::US10711020, Example 238 Nuclear receptor ROR-gamma [262-507] 71.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382529 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382529&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 145995597 404851891 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931151 CN1C(CCS1(=O)=O)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C26H24F8N2O5S2/c1-35-20(10-13-42(35,38)39)22(37)36-12-11-23(43(40,41)18-6-4-17(27)5-7-18)19-8-3-16(14-15(19)2-9-21(23)36)24(28,25(29,30)31)26(32,33)34/h3-8,14,20-21H,2,9-13H2,1H3/t20?,21-,23-/m1/s1 YFUKOVVZMSALOZ-CQQDSARBSA-N 382530 US10273259, Example 239::US10711020, Example 239 Nuclear receptor ROR-gamma [262-507] 14.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382530 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382530&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 145995598 404851892 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931152 CN1CC(CC1=O)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C27H24F8N2O4S/c1-36-14-16(13-22(36)38)23(39)37-11-10-24(42(40,41)19-6-4-18(28)5-7-19)20-8-3-17(12-15(20)2-9-21(24)37)25(29,26(30,31)32)27(33,34)35/h3-8,12,16,21H,2,9-11,13-14H2,1H3/t16?,21-,24-/m1/s1 HFWOMLYIVVVHFI-DKAGOCCWSA-N 382531 US10273259, Example 240::US10711020, Example 240 Nuclear receptor ROR-gamma [262-507] 13.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382531 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382531&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 145995599 404851893 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931153 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1CCC(=O)N1CCC#N InChI=1S/C29H25F8N3O4S/c30-19-4-6-20(7-5-19)45(43,44)26-12-15-40(25(42)22-9-11-24(41)39(22)14-1-13-38)23(26)10-2-17-16-18(3-8-21(17)26)27(31,28(32,33)34)29(35,36)37/h3-8,16,22-23H,1-2,9-12,14-15H2/t22?,23-,26-/m1/s1 XDDWLXGEQFTMIY-IQIYYKORSA-N 382532 US10273259, Example 241::US10711020, Example 241 Nuclear receptor ROR-gamma [262-507] 36.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382532 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382532&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678947 404851894 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931154 CN1C(=O)CCC1(C)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H26F8N2O4S/c1-24(12-11-22(39)37(24)2)23(40)38-14-13-25(43(41,42)19-7-5-18(29)6-8-19)20-9-4-17(15-16(20)3-10-21(25)38)26(30,27(31,32)33)28(34,35)36/h4-9,15,21H,3,10-14H2,1-2H3/t21-,24?,25-/m1/s1 ULPQTSLOGZZSRD-TYIXABJVSA-N 382533 US10273259, Example 242::US10711020, Example 242 Nuclear receptor ROR-gamma [262-507] 25.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382533 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382533&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 145995600 404851895 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931155 CN1[C@@H](C[C@H](F)C1=O)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C27H23F9N2O4S/c1-37-20(13-19(29)22(37)39)23(40)38-11-10-24(43(41,42)17-6-4-16(28)5-7-17)18-8-3-15(12-14(18)2-9-21(24)38)25(30,26(31,32)33)27(34,35)36/h3-8,12,19-21H,2,9-11,13H2,1H3/t19-,20-,21+,24+/m0/s1 PDJZLHFYLDTXLV-VMIIQTFKSA-N 382522 US10273259, Example 231::US10273259, Example 243::US10711020, Example 243 Nuclear receptor ROR-gamma [262-507] 64.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382522 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382522&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678541 404851884 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931156 CC(C)N1[C@@H](C[C@H](F)C1=O)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C29H27F9N2O4S/c1-15(2)40-22(14-21(31)24(40)41)25(42)39-12-11-26(45(43,44)19-7-5-18(30)6-8-19)20-9-4-17(13-16(20)3-10-23(26)39)27(32,28(33,34)35)29(36,37)38/h4-9,13,15,21-23H,3,10-12,14H2,1-2H3/t21-,22-,23+,26+/m0/s1 ZLVIPALKYFKUPO-OHTANWTRSA-N 382535 US10273259, Example 244::US10711020, Example 244 Nuclear receptor ROR-gamma [262-507] 112 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382535 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382535&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678720 404851896 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931157 COCCN1[C@@H](C[C@H](F)C1=O)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C29H27F9N2O5S/c1-45-13-12-39-22(15-21(31)24(39)41)25(42)40-11-10-26(46(43,44)19-6-4-18(30)5-7-19)20-8-3-17(14-16(20)2-9-23(26)40)27(32,28(33,34)35)29(36,37)38/h3-8,14,21-23H,2,9-13,15H2,1H3/t21-,22-,23+,26+/m0/s1 IKFKMNGGPLUNSF-OHTANWTRSA-N 382536 US10273259, Example 245::US10711020, Example 245 Nuclear receptor ROR-gamma [262-507] 54.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382536 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382536&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678823 404851897 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931158 CN1[C@@H](C[C@H](O)C1=O)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C27H24F8N2O5S/c1-36-19(13-20(38)23(36)40)22(39)37-11-10-24(43(41,42)17-6-4-16(28)5-7-17)18-8-3-15(12-14(18)2-9-21(24)37)25(29,26(30,31)32)27(33,34)35/h3-8,12,19-21,38H,2,9-11,13H2,1H3/t19-,20-,21+,24+/m0/s1 KAKUQEOIEAWDFB-VMIIQTFKSA-N 382537 US10273259, Example 246::US10273259, Example 494::US10711020, Example 494 Nuclear receptor ROR-gamma [262-507] 46.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382537 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382537&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678788 404851898 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931159 OC(=O)C12CCC(CC1)(CC2)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1cccc(F)c1 InChI=1S/C31H29F8NO5S/c32-20-2-1-3-21(17-20)46(44,45)28-14-15-40(24(41)26-8-11-27(12-9-26,13-10-26)25(42)43)23(28)7-4-18-16-19(5-6-22(18)28)29(33,30(34,35)36)31(37,38)39/h1-3,5-6,16-17,23H,4,7-15H2,(H,42,43) QVKAWLKXDAVRSX-UHFFFAOYSA-N 382538 US10273259, Example 247::US10711020, Example 247 Nuclear receptor ROR-gamma [262-507] 40.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382538 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382538&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679076 404851899 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931160 OC(=O)[C@H]1CC[C@@](F)(CC1)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1cccc(F)c1 InChI=1S/C29H26F9NO5S/c30-19-2-1-3-20(15-19)45(43,44)26-12-13-39(24(42)25(31)10-8-16(9-11-25)23(40)41)22(26)7-4-17-14-18(5-6-21(17)26)27(32,28(33,34)35)29(36,37)38/h1-3,5-6,14-16,22H,4,7-13H2,(H,40,41)/t16-,22?,25+,26? ZOJNDSHZKIPWLY-VXBFRIGJSA-N 382539 US10273259, Example 248::US10711020, Example 248 Nuclear receptor ROR-gamma [262-507] 34.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382539 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382539&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678950 404851900 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931161 C[C@@]1(CC[C@@H](CC1)C(O)=O)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1cccc(F)c1 InChI=1S/C30H29F8NO5S/c1-26(11-9-17(10-12-26)24(40)41)25(42)39-14-13-27(45(43,44)21-4-2-3-20(31)16-21)22-7-6-19(15-18(22)5-8-23(27)39)28(32,29(33,34)35)30(36,37)38/h2-4,6-7,15-17,23H,5,8-14H2,1H3,(H,40,41)/t17-,23?,26-,27? IAEWJYSPAAAVCL-PYPIJRSMSA-N 382540 US10273259, Example 249::US10711020, Example 249 Nuclear receptor ROR-gamma [262-507] 68.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382540 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382540&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679060 404851901 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931162 Fc1cccc(c1)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1CCS(=O)(=O)CC1 InChI=1S/C27H25F8NO5S2/c28-19-2-1-3-20(15-19)43(40,41)24-10-11-36(23(37)16-8-12-42(38,39)13-9-16)22(24)7-4-17-14-18(5-6-21(17)24)25(29,26(30,31)32)27(33,34)35/h1-3,5-6,14-16,22H,4,7-13H2 OBOQQJZBXHFEFQ-UHFFFAOYSA-N 382541 US10273259, Example 250::US10273259, Example 253::US10711020, Example 253 Nuclear receptor ROR-gamma [262-507] 46.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382541 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382541&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678598 404851902 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931163 OC(=O)[C@H]1CC[C@@](O)(CC1)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1cccc(F)c1 InChI=1S/C29H27F8NO6S/c30-19-2-1-3-20(15-19)45(43,44)26-12-13-38(24(41)25(42)10-8-16(9-11-25)23(39)40)22(26)7-4-17-14-18(5-6-21(17)26)27(31,28(32,33)34)29(35,36)37/h1-3,5-6,14-16,22,42H,4,7-13H2,(H,39,40)/t16-,22?,25+,26? CYSYXHPBNQFPED-VXBFRIGJSA-N 382542 US10273259, Example 251::US10711020, Example 251 Nuclear receptor ROR-gamma [262-507] 54.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382542 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382542&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679040 404851903 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931164 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1cccc(F)c1 InChI=1S/C29H27F8NO5S/c30-20-2-1-3-21(15-20)44(42,43)26-12-13-38(24(39)16-4-6-17(7-5-16)25(40)41)23(26)11-8-18-14-19(9-10-22(18)26)27(31,28(32,33)34)29(35,36)37/h1-3,9-10,14-17,23H,4-8,11-13H2,(H,40,41)/t16-,17-,23?,26? LIWMGZMUBKUREU-LRVXPCDCSA-N 382543 US10273259, Example 252::US10711020, Example 265 Nuclear receptor ROR-gamma [262-507] 48.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382543 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382543&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679068 404851904 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931165 Fc1cccc(c1)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1CCS(=O)(=O)CC1 InChI=1S/C27H25F8NO5S2/c28-19-2-1-3-20(15-19)43(40,41)24-10-11-36(23(37)16-8-12-42(38,39)13-9-16)22(24)7-4-17-14-18(5-6-21(17)24)25(29,26(30,31)32)27(33,34)35/h1-3,5-6,14-16,22H,4,7-13H2 OBOQQJZBXHFEFQ-UHFFFAOYSA-N 382541 US10273259, Example 250::US10273259, Example 253::US10711020, Example 253 Nuclear receptor ROR-gamma [262-507] 3556 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382541 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382541&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678598 404851902 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931166 OC(=O)C12CCC(CC1)(CO2)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C30H27F8NO6S/c31-19-3-5-20(6-4-19)46(43,44)27-13-14-39(23(40)25-9-11-26(12-10-25,24(41)42)45-16-25)22(27)8-1-17-15-18(2-7-21(17)27)28(32,29(33,34)35)30(36,37)38/h2-7,15,22H,1,8-14,16H2,(H,41,42)/t22-,25?,26?,27-/m1/s1 OFTMRBWXEACVFZ-LPDNJITPSA-N 382545 US10273259, Example 254::US10711020, Example 254 Nuclear receptor ROR-gamma [262-507] 84.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382545 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382545&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678615 404851905 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931167 OC(=O)C12CCC(CC1)(OC2)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C30H27F8NO6S/c31-19-3-5-20(6-4-19)46(43,44)27-13-14-39(23(40)26-11-9-25(10-12-26,16-45-26)24(41)42)22(27)8-1-17-15-18(2-7-21(17)27)28(32,29(33,34)35)30(36,37)38/h2-7,15,22H,1,8-14,16H2,(H,41,42)/t22-,25?,26?,27-/m1/s1 RVUSZWSBSZBUBX-LPDNJITPSA-N 382546 US10273259, Example 255::US10711020, Example 255 Nuclear receptor ROR-gamma [262-507] 24.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382546 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382546&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678952 404851906 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931168 OC(=O)C12CCC(CC1)(OC2)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(Cl)cc1 InChI=1S/C30H27ClF7NO6S/c31-19-3-5-20(6-4-19)46(43,44)27-13-14-39(23(40)26-11-9-25(10-12-26,16-45-26)24(41)42)22(27)8-1-17-15-18(2-7-21(17)27)28(32,29(33,34)35)30(36,37)38/h2-7,15,22H,1,8-14,16H2,(H,41,42) VKVORPFBSUVVNV-UHFFFAOYSA-N 382547 US10273259, Example 256::US10711020, Example 256 Nuclear receptor ROR-gamma [262-507] 324 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382547 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382547&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678616 404851907 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931169 OC(=O)C1CC2(C1)CC(C2)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(Cl)cc1 InChI=1S/C30H27ClF7NO5S/c31-20-3-5-21(6-4-20)45(43,44)27-9-10-39(24(40)17-12-26(13-17)14-18(15-26)25(41)42)23(27)8-1-16-11-19(2-7-22(16)27)28(32,29(33,34)35)30(36,37)38/h2-7,11,17-18,23H,1,8-10,12-15H2,(H,41,42) RGXXEOFNVGRMPO-UHFFFAOYSA-N 453294 US10711020, Example 257 Nuclear receptor ROR-gamma [262-507] 124 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=453294 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=453294&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679078 440969259 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931170 CN1CCC(CC1=O)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H26F8N2O4S/c1-37-12-10-17(15-23(37)39)24(40)38-13-11-25(43(41,42)20-6-4-19(29)5-7-20)21-8-3-18(14-16(21)2-9-22(25)38)26(30,27(31,32)33)28(34,35)36/h3-8,14,17,22H,2,9-13,15H2,1H3/t17?,22-,25-/m1/s1 YDBZXBHDAXQLST-MUNXEIQQSA-N 382549 US10273259, Example 258::US10711020, Example 258 Nuclear receptor ROR-gamma [262-507] 12.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382549 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382549&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678458 404851909 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931171 OC1(CCS(=O)(=O)CC1)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1cccc(F)c1 InChI=1S/C27H25F8NO6S2/c28-18-2-1-3-19(15-18)44(41,42)24-8-11-36(22(37)23(38)9-12-43(39,40)13-10-23)21(24)7-4-16-14-17(5-6-20(16)24)25(29,26(30,31)32)27(33,34)35/h1-3,5-6,14-15,21,38H,4,7-13H2 SURGLXFVHQGKJJ-UHFFFAOYSA-N 382550 US10273259, Example 259::US10711020, Example 259 Nuclear receptor ROR-gamma [262-507] 75.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382550 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382550&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678951 404851910 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931172 CC(C)(CC(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1cccc(F)c1)C(O)=O InChI=1S/C27H25F8NO5S/c1-23(2,22(38)39)14-21(37)36-11-10-24(42(40,41)18-5-3-4-17(28)13-18)19-8-7-16(12-15(19)6-9-20(24)36)25(29,26(30,31)32)27(33,34)35/h3-5,7-8,12-13,20H,6,9-11,14H2,1-2H3,(H,38,39) WENPJLVMTZTJFZ-UHFFFAOYSA-N 382551 US10273259, Example 260::US10711020, Example 260 Nuclear receptor ROR-gamma [262-507] 75.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382551 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382551&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679054 404851911 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931173 OC(=O)[C@]1(O)CC[C@@H](CC1)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1cccc(F)c1 InChI=1S/C29H27F8NO6S/c30-19-2-1-3-20(15-19)45(43,44)26-12-13-38(23(39)16-8-10-25(42,11-9-16)24(40)41)22(26)7-4-17-14-18(5-6-21(17)26)27(31,28(32,33)34)29(35,36)37/h1-3,5-6,14-16,22,42H,4,7-13H2,(H,40,41)/t16-,22?,25-,26? QIVQLOROWZUEMV-FVSSTLBOSA-N 382552 US10273259, Example 261::US10711020, Example 261 Nuclear receptor ROR-gamma [262-507] 115 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382552 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382552&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679048 404851912 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931174 CC(C)[C@@H](CC(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1cccc(F)c1)C(O)=O InChI=1S/C28H27F8NO5S/c1-15(2)20(24(39)40)14-23(38)37-11-10-25(43(41,42)19-5-3-4-18(29)13-19)21-8-7-17(12-16(21)6-9-22(25)37)26(30,27(31,32)33)28(34,35)36/h3-5,7-8,12-13,15,20,22H,6,9-11,14H2,1-2H3,(H,39,40)/t20-,22?,25?/m1/s1 ICFMTTWVAHXYNR-HUFXOUDFSA-N 382553 US10273259, Example 262::US10711020, Example 262 Nuclear receptor ROR-gamma [262-507] 69.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382553 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382553&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678832 404851913 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931175 OC(=O)CC(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1cccc(F)c1 InChI=1S/C24H19F8NO5S/c25-15-2-1-3-16(11-15)39(37,38)21-8-9-33(19(34)12-20(35)36)18(21)7-4-13-10-14(5-6-17(13)21)22(26,23(27,28)29)24(30,31)32/h1-3,5-6,10-11,18H,4,7-9,12H2,(H,35,36) CLOWCGWHESTLIG-UHFFFAOYSA-N 382554 US10273259, Example 263::US10711020, Example 263 Nuclear receptor ROR-gamma [262-507] 648 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382554 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382554&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678954 404851914 C01656 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931176 CC(C)(CC(O)=O)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1cccc(F)c1 InChI=1S/C27H25F8NO5S/c1-23(2,14-21(37)38)22(39)36-11-10-24(42(40,41)18-5-3-4-17(28)13-18)19-8-7-16(12-15(19)6-9-20(24)36)25(29,26(30,31)32)27(33,34)35/h3-5,7-8,12-13,20H,6,9-11,14H2,1-2H3,(H,37,38) WDBWWFALMRQCBC-UHFFFAOYSA-N 382555 US10273259, Example 264::US10711020, Example 264 Nuclear receptor ROR-gamma [262-507] 16.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382555 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382555&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678504 404851915 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931177 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1cccc(F)c1 InChI=1S/C29H27F8NO5S/c30-20-2-1-3-21(15-20)44(42,43)26-12-13-38(24(39)16-4-6-17(7-5-16)25(40)41)23(26)11-8-18-14-19(9-10-22(18)26)27(31,28(32,33)34)29(35,36)37/h1-3,9-10,14-17,23H,4-8,11-13H2,(H,40,41)/t16-,17-,23?,26? LIWMGZMUBKUREU-LRVXPCDCSA-N 382543 US10273259, Example 252::US10711020, Example 265 Nuclear receptor ROR-gamma [262-507] 3098 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382543 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382543&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679068 404851904 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931178 Cc1ccc(cc1)S(=O)(=O)C12CCN(C1COc1cc(Br)ccc21)C(=O)[C@H]1CC[C@@H](CC1)C(O)=O InChI=1S/C26H28BrNO6S/c1-16-2-9-20(10-3-16)35(32,33)26-12-13-28(24(29)17-4-6-18(7-5-17)25(30)31)23(26)15-34-22-14-19(27)8-11-21(22)26/h2-3,8-11,14,17-18,23H,4-7,12-13,15H2,1H3,(H,30,31)/t17-,18-,23?,26? AFINFWAWCZYKJF-GIHSMNABSA-N 382557 US10273259, Example 266::US10711020, Example 266 Nuclear receptor ROR-gamma [262-507] 1652 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382557 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382557&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678539 404851917 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931179 Cc1ccc(cc1)S(=O)(=O)C12CCN(C1COc1cc(Br)ccc21)C(=O)C12CCC(CC1)(CC2)C(O)=O InChI=1S/C28H30BrNO6S/c1-18-2-5-20(6-3-18)37(34,35)28-14-15-30(23(28)17-36-22-16-19(29)4-7-21(22)28)24(31)26-8-11-27(12-9-26,13-10-26)25(32)33/h2-7,16,23H,8-15,17H2,1H3,(H,32,33) WSRCYQFNPFFCMX-UHFFFAOYSA-N 382558 US10273259, Example 267::US10711020, Example 267 Nuclear receptor ROR-gamma [262-507] 182 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382558 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382558&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678501 404851918 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931180 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CCC2(C1CCc1cc(Br)ccc21)S(=O)(=O)c1cccc(F)c1 InChI=1S/C26H27BrFNO5S/c27-19-9-10-22-18(14-19)8-11-23-26(22,35(33,34)21-3-1-2-20(28)15-21)12-13-29(23)24(30)16-4-6-17(7-5-16)25(31)32/h1-3,9-10,14-17,23H,4-8,11-13H2,(H,31,32)/t16-,17-,23?,26? FLUGMCIXCKJUHH-LRVXPCDCSA-N 382559 US10273259, Example 268::US10711020, Example 268 Nuclear receptor ROR-gamma [262-507] 108 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382559 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382559&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679071 404851919 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931181 CC(C)(C)c1ccc2c(CCC3N(CCC23S(=O)(=O)c2cccc(F)c2)C(=O)[C@H]2CC[C@@H](CC2)C(O)=O)c1 InChI=1S/C30H36FNO5S/c1-29(2,3)22-12-13-25-21(17-22)11-14-26-30(25,38(36,37)24-6-4-5-23(31)18-24)15-16-32(26)27(33)19-7-9-20(10-8-19)28(34)35/h4-6,12-13,17-20,26H,7-11,14-16H2,1-3H3,(H,34,35)/t19-,20-,26?,30? NRSPFIZINSCLCX-XZJQCRQJSA-N 382560 US10273259, Example 269::US10273259, Example 270::US10711020, Example 270 Nuclear receptor ROR-gamma [262-507] 44.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382560 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382560&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678464 404851920 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931182 CC(C)(C)c1ccc2c(CCC3N(CCC23S(=O)(=O)c2cccc(F)c2)C(=O)[C@H]2CC[C@@H](CC2)C(O)=O)c1 InChI=1S/C30H36FNO5S/c1-29(2,3)22-12-13-25-21(17-22)11-14-26-30(25,38(36,37)24-6-4-5-23(31)18-24)15-16-32(26)27(33)19-7-9-20(10-8-19)28(34)35/h4-6,12-13,17-20,26H,7-11,14-16H2,1-3H3,(H,34,35)/t19-,20-,26?,30? NRSPFIZINSCLCX-XZJQCRQJSA-N 382560 US10273259, Example 269::US10273259, Example 270::US10711020, Example 270 Nuclear receptor ROR-gamma [262-507] 3430 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382560 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382560&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678464 404851920 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931183 CC(C)(C)c1ccc2c(CCC3N(CCC23S(=O)(=O)c2cccc(F)c2)C(=O)C23CCC(CC2)(CC3)C(O)=O)c1 InChI=1S/C32H38FNO5S/c1-29(2,3)22-8-9-25-21(19-22)7-10-26-32(25,40(38,39)24-6-4-5-23(33)20-24)17-18-34(26)27(35)30-11-14-31(15-12-30,16-13-30)28(36)37/h4-6,8-9,19-20,26H,7,10-18H2,1-3H3,(H,36,37) OKAADCSOQUCVGS-UHFFFAOYSA-N 382562 US10273259, Example 271::US10711020, Example 271 Nuclear receptor ROR-gamma [262-507] 50.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382562 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382562&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679072 404851921 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931184 CC(C)(C)c1ccc2c(CCC3N(CCC23S(=O)(=O)c2cccc(F)c2)C(=O)C2CCS(=O)(=O)CC2)c1 InChI=1S/C28H34FNO5S2/c1-27(2,3)21-8-9-24-20(17-21)7-10-25-28(24,37(34,35)23-6-4-5-22(29)18-23)13-14-30(25)26(31)19-11-15-36(32,33)16-12-19/h4-6,8-9,17-19,25H,7,10-16H2,1-3H3 MPYDARFDYPFKMC-UHFFFAOYSA-N 382563 US10273259, Example 272::US10711020, Example 272 Nuclear receptor ROR-gamma [262-507] 42.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382563 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382563&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679085 404851922 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931185 Cc1cc(ccc1Cl)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)[C@H]1CC[C@@H](CC1)C(O)=O InChI=1S/C30H29ClF7NO5S/c1-16-14-21(8-10-23(16)31)45(43,44)27-12-13-39(25(40)17-2-4-18(5-3-17)26(41)42)24(27)11-6-19-15-20(7-9-22(19)27)28(32,29(33,34)35)30(36,37)38/h7-10,14-15,17-18,24H,2-6,11-13H2,1H3,(H,41,42)/t17-,18-,24?,27? CXZPWDRHFGQVNB-VRSFHCCXSA-N 382564 US10273259, Example 273::US10273259, Example 278::US10711020, Example 278 Nuclear receptor ROR-gamma [262-507] 64.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382564 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382564&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678710 404851923 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931186 Cc1cc(ccc1Cl)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C12CCC(CC1)(CC2)C(O)=O InChI=1S/C32H31ClF7NO5S/c1-18-16-21(4-6-23(18)33)47(45,46)29-14-15-41(25(42)27-8-11-28(12-9-27,13-10-27)26(43)44)24(29)7-2-19-17-20(3-5-22(19)29)30(34,31(35,36)37)32(38,39)40/h3-6,16-17,24H,2,7-15H2,1H3,(H,43,44) XTTDRKVWPOUOJI-UHFFFAOYSA-N 382565 US10273259, Example 274::US10711020, Example 274 Nuclear receptor ROR-gamma [262-507] 179 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382565 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382565&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678839 404851924 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931187 Cc1cc(ccc1Cl)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)[C@@]1(O)CC[C@@H](CC1)C(O)=O InChI=1S/C30H29ClF7NO6S/c1-16-14-20(4-6-22(16)31)46(44,45)27-12-13-39(25(42)26(43)10-8-17(9-11-26)24(40)41)23(27)7-2-18-15-19(3-5-21(18)27)28(32,29(33,34)35)30(36,37)38/h3-6,14-15,17,23,43H,2,7-13H2,1H3,(H,40,41)/t17-,23?,26+,27? DRGNQJLXZGBYPJ-MTOUGUCQSA-N 382566 US10273259, Example 275::US10711020, Example 275 Nuclear receptor ROR-gamma [262-507] 150 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382566 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382566&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678612 404851925 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931188 Cc1cc(ccc1Cl)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)[C@@]1(C)CC[C@@H](CC1)C(O)=O InChI=1S/C31H31ClF7NO5S/c1-17-15-21(5-7-23(17)32)46(44,45)28-13-14-40(26(43)27(2)11-9-18(10-12-27)25(41)42)24(28)8-3-19-16-20(4-6-22(19)28)29(33,30(34,35)36)31(37,38)39/h4-7,15-16,18,24H,3,8-14H2,1-2H3,(H,41,42)/t18-,24?,27-,28? CRUSBSVDMSHIJP-GLMFJJLTSA-N 382567 US10273259, Example 276::US10711020, Example 276 Nuclear receptor ROR-gamma [262-507] 166 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382567 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382567&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678856 404851926 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931189 Cc1cc(ccc1Cl)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)[C@H]1CC[C@@](C)(CC1)C(O)=O InChI=1S/C31H31ClF7NO5S/c1-17-15-21(5-7-23(17)32)46(44,45)28-13-14-40(25(41)18-9-11-27(2,12-10-18)26(42)43)24(28)8-3-19-16-20(4-6-22(19)28)29(33,30(34,35)36)31(37,38)39/h4-7,15-16,18,24H,3,8-14H2,1-2H3,(H,42,43)/t18-,24?,27-,28? OVEJXCRQIMBGPQ-GLMFJJLTSA-N 382568 US10273259, Example 277::US10711020, Example 277 Nuclear receptor ROR-gamma [262-507] 68.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382568 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382568&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678717 404851927 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931190 Cc1cc(ccc1Cl)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)[C@H]1CC[C@@H](CC1)C(O)=O InChI=1S/C30H29ClF7NO5S/c1-16-14-21(8-10-23(16)31)45(43,44)27-12-13-39(25(40)17-2-4-18(5-3-17)26(41)42)24(27)11-6-19-15-20(7-9-22(19)27)28(32,29(33,34)35)30(36,37)38/h7-10,14-15,17-18,24H,2-6,11-13H2,1H3,(H,41,42)/t17-,18-,24?,27? CXZPWDRHFGQVNB-VRSFHCCXSA-N 382564 US10273259, Example 273::US10273259, Example 278::US10711020, Example 278 Nuclear receptor ROR-gamma [262-507] 5561 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382564 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382564&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678710 404851923 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931191 Cc1cc(ccc1F)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C12CCC(CC1)(CC2)C(O)=O InChI=1S/C32H31F8NO5S/c1-18-16-21(4-6-23(18)33)47(45,46)29-14-15-41(25(42)27-8-11-28(12-9-27,13-10-27)26(43)44)24(29)7-2-19-17-20(3-5-22(19)29)30(34,31(35,36)37)32(38,39)40/h3-6,16-17,24H,2,7-15H2,1H3,(H,43,44) SHMZBEASAIVZGQ-UHFFFAOYSA-N 382570 US10273259, Example 279::US10273259, Example 406::US10711020, Example 406 Nuclear receptor ROR-gamma [262-507] 42.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382570 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382570&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679057 404851928 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931192 Cc1cc(ccc1F)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)[C@@]1(F)CC[C@@H](CC1)C(O)=O InChI=1S/C30H28F9NO5S/c1-16-14-20(4-6-22(16)31)46(44,45)27-12-13-40(25(43)26(32)10-8-17(9-11-26)24(41)42)23(27)7-2-18-15-19(3-5-21(18)27)28(33,29(34,35)36)30(37,38)39/h3-6,14-15,17,23H,2,7-13H2,1H3,(H,41,42)/t17-,23?,26+,27? HMUIKTMNWCIRAR-MTOUGUCQSA-N 382571 US10273259, Example 280::US10711020, Example 407 Nuclear receptor ROR-gamma [262-507] 52.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382571 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382571&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678841 404851929 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931193 Cc1cc(ccc1F)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)[C@H]1CC[C@@H](CC1)C(O)=O InChI=1S/C30H29F8NO5S/c1-16-14-21(8-10-23(16)31)45(43,44)27-12-13-39(25(40)17-2-4-18(5-3-17)26(41)42)24(27)11-6-19-15-20(7-9-22(19)27)28(32,29(33,34)35)30(36,37)38/h7-10,14-15,17-18,24H,2-6,11-13H2,1H3,(H,41,42)/t17-,18-,24?,27? HLPIMFURZPXHEZ-VRSFHCCXSA-N 382684 US10273259, Example 393::US10273259, Example 394::US10711020, Example 394 Nuclear receptor ROR-gamma [262-507] 32.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382684 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382684&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678625 404852035 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931194 Cc1cc(ccc1F)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1CCS(=O)(=O)CC1 InChI=1S/C28H27F8NO5S2/c1-16-14-20(4-6-22(16)29)44(41,42)25-10-11-37(24(38)17-8-12-43(39,40)13-9-17)23(25)7-2-18-15-19(3-5-21(18)25)26(30,27(31,32)33)28(34,35)36/h3-6,14-15,17,23H,2,7-13H2,1H3 ZLKCPAJNBVGSGB-UHFFFAOYSA-N 382573 US10273259, Example 282::US10273259, Example 392::US10711020, Example 392 Nuclear receptor ROR-gamma [262-507] 55.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382573 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382573&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678618 404851931 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931195 Cc1cc(ccc1F)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1CC2(CC(C2)C(O)=O)C1 InChI=1S/C31H29F8NO5S/c1-16-10-21(4-6-23(16)32)46(44,45)28-8-9-40(25(41)18-12-27(13-18)14-19(15-27)26(42)43)24(28)7-2-17-11-20(3-5-22(17)28)29(33,30(34,35)36)31(37,38)39/h3-6,10-11,18-19,24H,2,7-9,12-15H2,1H3,(H,42,43) JSFTYTJBIXKDLT-UHFFFAOYSA-N 453320 US10711020, Example 283 Nuclear receptor ROR-gamma [262-507] 33.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=453320 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=453320&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 145995601 440969275 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931196 CC(=O)N[C@H]1CC[C@H](CC1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C30H30F8N2O4S/c1-17(41)39-22-8-2-18(3-9-22)26(42)40-15-14-27(45(43,44)23-10-6-21(31)7-11-23)24-12-5-20(16-19(24)4-13-25(27)40)28(32,29(33,34)35)30(36,37)38/h5-7,10-12,16,18,22,25H,2-4,8-9,13-15H2,1H3,(H,39,41)/t18-,22+,25-,27-/m1/s1 FCWDXBLPNWKWRH-XGHUSFQNSA-N 382575 US10273259, Example 284::US10711020, Example 284 Nuclear receptor ROR-gamma [262-507] 51.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382575 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382575&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678543 404851933 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931197 CC(=O)N[C@H]1CC[C@@H](CC1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C30H30F8N2O4S/c1-17(41)39-22-8-2-18(3-9-22)26(42)40-15-14-27(45(43,44)23-10-6-21(31)7-11-23)24-12-5-20(16-19(24)4-13-25(27)40)28(32,29(33,34)35)30(36,37)38/h5-7,10-12,16,18,22,25H,2-4,8-9,13-15H2,1H3,(H,39,41)/t18-,22-,25-,27-/m1/s1 FCWDXBLPNWKWRH-ZDABEDDOSA-N 382576 US10273259, Example 285::US10711020, Example 285 Nuclear receptor ROR-gamma [262-507] 46.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382576 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382576&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678543 404851934 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931198 CC(=O)NC12CCC(CC1)(CC2)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C32H32F8N2O4S/c1-19(43)41-28-13-10-27(11-14-28,12-15-28)26(44)42-17-16-29(47(45,46)23-6-4-22(33)5-7-23)24-8-3-21(18-20(24)2-9-25(29)42)30(34,31(35,36)37)32(38,39)40/h3-8,18,25H,2,9-17H2,1H3,(H,41,43)/t25-,27?,28?,29-/m1/s1 CWZVPVLLTKPSAH-RFBOAJLRSA-N 382577 US10273259, Example 286::US10711020, Example 286 Nuclear receptor ROR-gamma [262-507] 88.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382577 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382577&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678709 404851935 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931199 OC(=O)C1CC2(C1)CC(C2)C(=O)N1CCCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1cccc(F)c1 InChI=1S/C31H29F8NO5S/c32-21-3-1-4-22(12-21)46(44,45)28-9-2-10-40(25(41)18-13-27(14-18)15-19(16-27)26(42)43)24(28)8-5-17-11-20(6-7-23(17)28)29(33,30(34,35)36)31(37,38)39/h1,3-4,6-7,11-12,18-19,24H,2,5,8-10,13-16H2,(H,42,43) HEPPQSRFVKCCOU-UHFFFAOYSA-N 382578 US10273259, Example 287::US10711020, Example 287 Nuclear receptor ROR-gamma [262-507] 40.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382578 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382578&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678864 404851936 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931200 OC(=O)C1CC2(C1)CC(C2)C(=O)N1CCCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C31H29F8NO5S/c32-21-4-6-22(7-5-21)46(44,45)28-10-1-11-40(25(41)18-13-27(14-18)15-19(16-27)26(42)43)24(28)9-2-17-12-20(3-8-23(17)28)29(33,30(34,35)36)31(37,38)39/h3-8,12,18-19,24H,1-2,9-11,13-16H2,(H,42,43) UKJAMYVHOFCMAX-UHFFFAOYSA-N 382579 US10273259, Example 288::US10711020, Example 288 Nuclear receptor ROR-gamma [262-507] 22.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382579 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382579&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678971 404851937 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931201 CC1CC(CCS1(=O)=O)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H27F8NO5S2/c1-16-14-18(10-13-43(16,39)40)24(38)37-12-11-25(44(41,42)21-6-4-20(29)5-7-21)22-8-3-19(15-17(22)2-9-23(25)37)26(30,27(31,32)33)28(34,35)36/h3-8,15-16,18,23H,2,9-14H2,1H3/t16?,18?,23-,25-/m1/s1 IOIGWHJVXBSMDU-WCCBJSLHSA-N 382580 US10273259, Example 289::US10273259, Example 290::US10711020, Example 290 Nuclear receptor ROR-gamma [262-507] 42.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382580 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382580&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 145995602 404851938 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931202 CC1CC(CCS1(=O)=O)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H27F8NO5S2/c1-16-14-18(10-13-43(16,39)40)24(38)37-12-11-25(44(41,42)21-6-4-20(29)5-7-21)22-8-3-19(15-17(22)2-9-23(25)37)26(30,27(31,32)33)28(34,35)36/h3-8,15-16,18,23H,2,9-14H2,1H3/t16?,18?,23-,25-/m1/s1 IOIGWHJVXBSMDU-WCCBJSLHSA-N 382580 US10273259, Example 289::US10273259, Example 290::US10711020, Example 290 Nuclear receptor ROR-gamma [262-507] 53.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382580 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382580&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 145995602 404851938 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931203 OC(=O)C12CCC(CC1)(CC2)C(=O)N1CCC2(C1CCc1cc(Cl)ccc21)S(=O)(=O)c1cccc(F)c1 InChI=1S/C28H29ClFNO5S/c29-19-5-6-22-18(16-19)4-7-23-28(22,37(35,36)21-3-1-2-20(30)17-21)14-15-31(23)24(32)26-8-11-27(12-9-26,13-10-26)25(33)34/h1-3,5-6,16-17,23H,4,7-15H2,(H,33,34) BSKKXSIZSHWHBM-UHFFFAOYSA-N 382582 US10273259, Example 291::US10711020, Example 291 Nuclear receptor ROR-gamma [262-507] 237 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382582 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382582&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679079 404851939 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931204 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CCC2(C1CCc1cc(Cl)ccc21)S(=O)(=O)c1cccc(F)c1 InChI=1S/C26H27ClFNO5S/c27-19-9-10-22-18(14-19)8-11-23-26(22,35(33,34)21-3-1-2-20(28)15-21)12-13-29(23)24(30)16-4-6-17(7-5-16)25(31)32/h1-3,9-10,14-17,23H,4-8,11-13H2,(H,31,32)/t16-,17-,23?,26? VRSSOVTVTCALKR-LRVXPCDCSA-N 382583 US10273259, Example 292::US10711020, Example 292 Nuclear receptor ROR-gamma [262-507] 134 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382583 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382583&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678697 404851940 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931205 C[C@H]1CN(C2CCc3cc(ccc3C12S(=O)(=O)c1ccc(F)cc1)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1CCS(=O)(=O)CC1 InChI=1S/C28H27F8NO5S2/c1-16-15-37(24(38)17-10-12-43(39,40)13-11-17)23-9-2-18-14-19(26(30,27(31,32)33)28(34,35)36)3-8-22(18)25(16,23)44(41,42)21-6-4-20(29)5-7-21/h3-8,14,16-17,23H,2,9-13,15H2,1H3/t16-,23?,25?/m0/s1 PDDCPKPORGRAHB-MQHNZPCDSA-N 382584 US10273259, Example 293::US10711020, Example 293 Nuclear receptor ROR-gamma [262-507] 160 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382584 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382584&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678611 404851941 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931206 C[C@H]1CN(C2CCc3cc(ccc3C12S(=O)(=O)c1ccc(F)cc1)C(F)(C(F)(F)F)C(F)(F)F)C(=O)[C@H]1CC[C@@H](CC1)C(O)=O InChI=1S/C30H29F8NO5S/c1-16-15-39(25(40)17-2-4-18(5-3-17)26(41)42)24-13-6-19-14-20(28(32,29(33,34)35)30(36,37)38)7-12-23(19)27(16,24)45(43,44)22-10-8-21(31)9-11-22/h7-12,14,16-18,24H,2-6,13,15H2,1H3,(H,41,42)/t16-,17-,18-,24?,27?/m0/s1 INLCDNRAIIGCBA-KGGGPQMJSA-N 382585 US10273259, Example 294::US10711020, Example 294 Nuclear receptor ROR-gamma [262-507] 125 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382585 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382585&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678621 404851942 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931207 C[C@H]1CC2(C(CCc3cc(ccc23)C(F)(C(F)(F)F)C(F)(F)F)N1C(=O)C1CCS(=O)(=O)CC1)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H27F8NO5S2/c1-16-15-25(44(41,42)21-6-4-20(29)5-7-21)22-8-3-19(26(30,27(31,32)33)28(34,35)36)14-18(22)2-9-23(25)37(16)24(38)17-10-12-43(39,40)13-11-17/h3-8,14,16-17,23H,2,9-13,15H2,1H3/t16-,23?,25?/m0/s1 IXIYUCDUDFGTPU-MQHNZPCDSA-N 382586 US10273259, Example 295::US10711020, Example 295 Nuclear receptor ROR-gamma [262-507] 205 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382586 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382586&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679082 404851943 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931208 C[C@@H]1CN(C2CCc3cc(ccc3C12S(=O)(=O)c1ccc(F)cc1)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1CCS(=O)(=O)CC1 InChI=1S/C28H27F8NO5S2/c1-16-15-37(24(38)17-10-12-43(39,40)13-11-17)23-9-2-18-14-19(26(30,27(31,32)33)28(34,35)36)3-8-22(18)25(16,23)44(41,42)21-6-4-20(29)5-7-21/h3-8,14,16-17,23H,2,9-13,15H2,1H3/t16-,23?,25?/m1/s1 PDDCPKPORGRAHB-UOMYTMTESA-N 382587 US10273259, Example 296::US10711020, Example 296 Nuclear receptor ROR-gamma [262-507] 55.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382587 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382587&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678514 404851944 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931209 C[C@@H]1CC2(C(CCc3cc(ccc23)C(F)(C(F)(F)F)C(F)(F)F)N1C(=O)C1CCS(=O)(=O)CC1)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H27F8NO5S2/c1-16-15-25(44(41,42)21-6-4-20(29)5-7-21)22-8-3-19(26(30,27(31,32)33)28(34,35)36)14-18(22)2-9-23(25)37(16)24(38)17-10-12-43(39,40)13-11-17/h3-8,14,16-17,23H,2,9-13,15H2,1H3/t16-,23?,25?/m1/s1 IXIYUCDUDFGTPU-UOMYTMTESA-N 382588 US10273259, Example 297::US10711020, Example 297 Nuclear receptor ROR-gamma [262-507] 43.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382588 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382588&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678457 404851945 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931210 C[C@@H]1CN(C2CCc3cc(ccc3C12S(=O)(=O)c1ccc(F)cc1)C(F)(C(F)(F)F)C(F)(F)F)C(=O)[C@H]1CC[C@@H](CC1)C(O)=O InChI=1S/C30H29F8NO5S/c1-16-15-39(25(40)17-2-4-18(5-3-17)26(41)42)24-13-6-19-14-20(28(32,29(33,34)35)30(36,37)38)7-12-23(19)27(16,24)45(43,44)22-10-8-21(31)9-11-22/h7-12,14,16-18,24H,2-6,13,15H2,1H3,(H,41,42)/t16-,17-,18-,24?,27?/m1/s1 INLCDNRAIIGCBA-NTUALMSUSA-N 382589 US10273259, Example 298::US10711020, Example 298 Nuclear receptor ROR-gamma [262-507] 49.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382589 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382589&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679098 404851946 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931211 C[C@H]1CC2(C(CCc3cc(ccc23)C(F)(C(F)(F)F)C(F)(F)F)N1C(=O)[C@H]1CC[C@@H](CC1)C(O)=O)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C30H29F8NO5S/c1-16-15-27(45(43,44)22-10-8-21(31)9-11-22)23-12-7-20(28(32,29(33,34)35)30(36,37)38)14-19(23)6-13-24(27)39(16)25(40)17-2-4-18(5-3-17)26(41)42/h7-12,14,16-18,24H,2-6,13,15H2,1H3,(H,41,42)/t16-,17-,18-,24?,27?/m0/s1 NLAWXJFYNVXSGK-KGGGPQMJSA-N 382590 US10273259, Example 299::US10711020, Example 299 Nuclear receptor ROR-gamma [262-507] 47.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382590 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382590&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678410 404851947 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931212 OC(=O)CN1[C@@H](CCC1=O)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H24F8N2O6S/c29-17-3-5-18(6-4-17)45(43,44)25-11-12-37(24(42)20-8-10-22(39)38(20)14-23(40)41)21(25)9-1-15-13-16(2-7-19(15)25)26(30,27(31,32)33)28(34,35)36/h2-7,13,20-21H,1,8-12,14H2,(H,40,41)/t20-,21+,25+/m0/s1 RMJOQNJGTTYNCO-BPYKYCOYSA-N 382591 US10273259, Example 300::US10711020, Example 300 Nuclear receptor ROR-gamma [262-507] 19.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382591 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382591&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678718 404851948 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931213 C[C@H]1CC2(C(CCc3cc(ccc23)C(F)(C(F)(F)F)C(F)(F)F)N1C(=O)C1(O)CCS(=O)(=O)CC1)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H27F8NO6S2/c1-16-15-25(45(42,43)20-6-4-19(29)5-7-20)21-8-3-18(26(30,27(31,32)33)28(34,35)36)14-17(21)2-9-22(25)37(16)23(38)24(39)10-12-44(40,41)13-11-24/h3-8,14,16,22,39H,2,9-13,15H2,1H3/t16-,22?,25?/m0/s1 AUVKXICOJLQARP-FPXRNPNWSA-N 382592 US10273259, Example 301::US10711020, Example 301 Nuclear receptor ROR-gamma [262-507] 89.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382592 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382592&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678840 404851949 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931214 C[C@H]1CC2(C(CCc3cc(ccc23)C(F)(C(F)(F)F)C(F)(F)F)N1C(=O)[C@@]1(F)CC[C@@H](CC1)C(O)=O)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C30H28F9NO5S/c1-16-15-27(46(44,45)21-6-4-20(31)5-7-21)22-8-3-19(28(33,29(34,35)36)30(37,38)39)14-18(22)2-9-23(27)40(16)25(43)26(32)12-10-17(11-13-26)24(41)42/h3-8,14,16-17,23H,2,9-13,15H2,1H3,(H,41,42)/t16-,17-,23?,26+,27?/m0/s1 DKGOXSGVARKBRJ-JYPCXJDLSA-N 382593 US10273259, Example 302::US10711020, Example 302 Nuclear receptor ROR-gamma [262-507] 154 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382593 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382593&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678630 404851950 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931215 C[C@H]1CN(C2CCc3cc(ccc3C12S(=O)(=O)c1ccc(F)cc1)C(F)(C(F)(F)F)C(F)(F)F)C(=O)[C@@]1(F)CC[C@@H](CC1)C(O)=O InChI=1S/C30H28F9NO5S/c1-16-15-40(25(43)26(32)12-10-17(11-13-26)24(41)42)23-9-2-18-14-19(28(33,29(34,35)36)30(37,38)39)3-8-22(18)27(16,23)46(44,45)21-6-4-20(31)5-7-21/h3-8,14,16-17,23H,2,9-13,15H2,1H3,(H,41,42)/t16-,17-,23?,26+,27?/m0/s1 PCCONJHZMXEANB-JYPCXJDLSA-N 382594 US10273259, Example 303::US10711020, Example 303 Nuclear receptor ROR-gamma [262-507] 38.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382594 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382594&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678977 404851951 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931216 OC(=O)[C@@H]1CCC(=O)N1CC(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H24F8N2O6S/c29-17-3-5-18(6-4-17)45(43,44)25-11-12-37(23(40)14-38-20(24(41)42)8-10-22(38)39)21(25)9-1-15-13-16(2-7-19(15)25)26(30,27(31,32)33)28(34,35)36/h2-7,13,20-21H,1,8-12,14H2,(H,41,42)/t20-,21+,25+/m0/s1 QEWNJCVCXUYNBH-BPYKYCOYSA-N 382595 US10273259, Example 304::US10711020, Example 304 Nuclear receptor ROR-gamma [262-507] 75.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382595 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382595&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678884 404851952 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931217 CC1(C)OCC(C)(CO1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C29H29F8NO5S/c1-24(2)42-15-25(3,16-43-24)23(39)38-13-12-26(44(40,41)20-8-6-19(30)7-9-20)21-10-5-18(14-17(21)4-11-22(26)38)27(31,28(32,33)34)29(35,36)37/h5-10,14,22H,4,11-13,15-16H2,1-3H3/t22-,26-/m1/s1 BDXQIXFFUBQGIT-ATIYNZHBSA-N 382596 US10273259, Example 305::US10711020, Example 305 Nuclear receptor ROR-gamma [262-507] 66.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382596 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382596&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122669231 404851953 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931218 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CCCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1cccc(F)c1 InChI=1S/C30H29F8NO5S/c31-21-3-1-4-22(16-21)45(43,44)27-13-2-14-39(25(40)17-5-7-18(8-6-17)26(41)42)24(27)12-9-19-15-20(10-11-23(19)27)28(32,29(33,34)35)30(36,37)38/h1,3-4,10-11,15-18,24H,2,5-9,12-14H2,(H,41,42)/t17-,18-,24?,27? FLCUOBVSOPIEMY-VRSFHCCXSA-N 382597 US10273259, Example 306::US10711020, Example 306 Nuclear receptor ROR-gamma [262-507] 31.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382597 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382597&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678978 404851954 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931219 OC(=O)C12CCC(CC1)(CC2)C(=O)N1CCCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1cccc(F)c1 InChI=1S/C32H31F8NO5S/c33-21-3-1-4-22(18-21)47(45,46)29-9-2-16-41(25(42)27-10-13-28(14-11-27,15-12-27)26(43)44)24(29)8-5-19-17-20(6-7-23(19)29)30(34,31(35,36)37)32(38,39)40/h1,3-4,6-7,17-18,24H,2,5,8-16H2,(H,43,44) LQNFAKZLTXMKMT-UHFFFAOYSA-N 382598 US10273259, Example 307::US10711020, Example 307 Nuclear receptor ROR-gamma [262-507] 35.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382598 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382598&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678525 404851955 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931220 Fc1cccc(c1)S(=O)(=O)C12CCCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1CCS(=O)(=O)CC1 InChI=1S/C28H27F8NO5S2/c29-20-3-1-4-21(16-20)44(41,42)25-11-2-12-37(24(38)17-9-13-43(39,40)14-10-17)23(25)8-5-18-15-19(6-7-22(18)25)26(30,27(31,32)33)28(34,35)36/h1,3-4,6-7,15-17,23H,2,5,8-14H2 NIVPOSHCFNLVCO-UHFFFAOYSA-N 382599 US10273259, Example 308::US10711020, Example 308 Nuclear receptor ROR-gamma [262-507] 26.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382599 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382599&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678885 404851956 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931221 C[C@@]1(CC[C@@H](CC1)C(O)=O)C(=O)N1CCCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1cccc(F)c1 InChI=1S/C31H31F8NO5S/c1-27(13-10-18(11-14-27)25(41)42)26(43)40-15-3-12-28(46(44,45)22-5-2-4-21(32)17-22)23-8-7-20(16-19(23)6-9-24(28)40)29(33,30(34,35)36)31(37,38)39/h2,4-5,7-8,16-18,24H,3,6,9-15H2,1H3,(H,41,42)/t18-,24?,27-,28? KNSUHCRQKJESPE-GLMFJJLTSA-N 382600 US10273259, Example 309::US10711020, Example 309 Nuclear receptor ROR-gamma [262-507] 56.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382600 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382600&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678518 404851957 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931222 Fc1ccc(cc1)S(=O)(=O)C12CCCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1CCS(=O)(=O)CC1 InChI=1S/C28H27F8NO5S2/c29-20-4-6-21(7-5-20)44(41,42)25-12-1-13-37(24(38)17-10-14-43(39,40)15-11-17)23(25)9-2-18-16-19(3-8-22(18)25)26(30,27(31,32)33)28(34,35)36/h3-8,16-17,23H,1-2,9-15H2 ILUFATUAWRPTIE-UHFFFAOYSA-N 382601 US10273259, Example 310::US10711020, Example 310 Nuclear receptor ROR-gamma [262-507] 184 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382601 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382601&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678725 404851958 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931223 OC(=O)C12CCC(CC1)(CC2)C(=O)N1CCCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C32H31F8NO5S/c33-21-4-6-22(7-5-21)47(45,46)29-10-1-17-41(25(42)27-11-14-28(15-12-27,16-13-27)26(43)44)24(29)9-2-19-18-20(3-8-23(19)29)30(34,31(35,36)37)32(38,39)40/h3-8,18,24H,1-2,9-17H2,(H,43,44) IISZWODINTVQOP-UHFFFAOYSA-N 382602 US10273259, Example 311::US10711020, Example 311 Nuclear receptor ROR-gamma [262-507] 37.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382602 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382602&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679095 404851959 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931224 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CCCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccccc1 InChI=1S/C30H30F7NO5S/c31-28(29(32,33)34,30(35,36)37)21-12-13-23-20(17-21)11-14-24-27(23,44(42,43)22-5-2-1-3-6-22)15-4-16-38(24)25(39)18-7-9-19(10-8-18)26(40)41/h1-3,5-6,12-13,17-19,24H,4,7-11,14-16H2,(H,40,41)/t18-,19-,24?,27? WTYIAQZPHNCSLJ-QXIWJBPRSA-N 382603 US10273259, Example 312::US10711020, Example 312 Nuclear receptor ROR-gamma [262-507] 68.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382603 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382603&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678875 404851960 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931225 OC(=O)C12CCC(CC1)(CC2)C(=O)N1CCCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccccc1 InChI=1S/C32H32F7NO5S/c33-30(31(34,35)36,32(37,38)39)21-8-9-23-20(19-21)7-10-24-29(23,46(44,45)22-5-2-1-3-6-22)11-4-18-40(24)25(41)27-12-15-28(16-13-27,17-14-27)26(42)43/h1-3,5-6,8-9,19,24H,4,7,10-18H2,(H,42,43) VINXYLSNORSEJE-UHFFFAOYSA-N 382604 US10273259, Example 313::US10711020, Example 313 Nuclear receptor ROR-gamma [262-507] 32.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382604 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382604&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678506 404851961 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931226 C[C@@]1(CC[C@@H](CC1)C(=O)N1CCCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccccc1)C(O)=O InChI=1S/C31H32F7NO5S/c1-27(26(41)42)15-12-19(13-16-27)25(40)39-17-5-14-28(45(43,44)22-6-3-2-4-7-22)23-10-9-21(18-20(23)8-11-24(28)39)29(32,30(33,34)35)31(36,37)38/h2-4,6-7,9-10,18-19,24H,5,8,11-17H2,1H3,(H,41,42)/t19-,24?,27-,28? FROWNVDAEYRDAL-XJNMGFQWSA-N 382605 US10273259, Example 314::US10711020, Example 314 Nuclear receptor ROR-gamma [262-507] 99.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382605 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382605&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678528 404851962 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931227 OC(=O)c1ccc(cc1)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1cccc(F)c1 InChI=1S/C29H21F8NO5S/c30-20-2-1-3-21(15-20)44(42,43)26-12-13-38(24(39)16-4-6-17(7-5-16)25(40)41)23(26)11-8-18-14-19(9-10-22(18)26)27(31,28(32,33)34)29(35,36)37/h1-7,9-10,14-15,23H,8,11-13H2,(H,40,41) FFEDCEHLNOSYJO-UHFFFAOYSA-N 382606 US10273259, Example 315::US10711020, Example 315 Nuclear receptor ROR-gamma [262-507] 97.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382606 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382606&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679083 404851963 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931228 OC(=O)Cc1ccc(CC(=O)N2CCC3(C2CCc2cc(ccc32)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c2cccc(F)c2)cc1 InChI=1S/C31H25F8NO5S/c32-22-2-1-3-23(17-22)46(44,45)28-12-13-40(26(41)14-18-4-6-19(7-5-18)15-27(42)43)25(28)11-8-20-16-21(9-10-24(20)28)29(33,30(34,35)36)31(37,38)39/h1-7,9-10,16-17,25H,8,11-15H2,(H,42,43) DPJNUSSDKWBHOF-UHFFFAOYSA-N 382607 US10273259, Example 316::US10711020, Example 316 Nuclear receptor ROR-gamma [262-507] 103 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382607 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382607&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678631 404851964 C03768 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931229 Fc1cccc(c1)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)Cc1ccc(cc1)C#N InChI=1S/C30H22F8N2O3S/c31-22-2-1-3-23(16-22)44(42,43)27-12-13-40(26(41)14-18-4-6-19(17-39)7-5-18)25(27)11-8-20-15-21(9-10-24(20)27)28(32,29(33,34)35)30(36,37)38/h1-7,9-10,15-16,25H,8,11-14H2 JEPADORYZCYPTI-UHFFFAOYSA-N 382608 US10273259, Example 317::US10711020, Example 317 Nuclear receptor ROR-gamma [262-507] 336 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382608 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382608&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678623 404851965 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931230 OC(=O)C1CCC(C1)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1cccc(F)c1 InChI=1S/C28H25F8NO5S/c29-19-2-1-3-20(14-19)43(41,42)25-10-11-37(23(38)16-4-5-17(12-16)24(39)40)22(25)9-6-15-13-18(7-8-21(15)25)26(30,27(31,32)33)28(34,35)36/h1-3,7-8,13-14,16-17,22H,4-6,9-12H2,(H,39,40) WBLHKOGHJJCBTF-UHFFFAOYSA-N 382609 US10273259, Example 318::US10711020, Example 318 Nuclear receptor ROR-gamma [262-507] 111 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382609 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382609&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678627 404851966 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931231 OC(=O)c1cccc(CC(=O)N2CCC3(C2CCc2cc(ccc32)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c2cccc(F)c2)c1 InChI=1S/C30H23F8NO5S/c31-21-5-2-6-22(16-21)45(43,44)27-11-12-39(25(40)14-17-3-1-4-19(13-17)26(41)42)24(27)10-7-18-15-20(8-9-23(18)27)28(32,29(33,34)35)30(36,37)38/h1-6,8-9,13,15-16,24H,7,10-12,14H2,(H,41,42) MMOQILWYIZMKNT-UHFFFAOYSA-N 382610 US10273259, Example 319::US10711020, Example 319 Nuclear receptor ROR-gamma [262-507] 78.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382610 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382610&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679114 404851967 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931232 OC(=O)c1cncc(CC(=O)N2CCC3(C2CCc2cc(ccc32)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c2cccc(F)c2)c1 InChI=1S/C29H22F8N2O5S/c30-20-2-1-3-21(13-20)45(43,44)26-8-9-39(24(40)11-16-10-18(25(41)42)15-38-14-16)23(26)7-4-17-12-19(5-6-22(17)26)27(31,28(32,33)34)29(35,36)37/h1-3,5-6,10,12-15,23H,4,7-9,11H2,(H,41,42) QNRDHNGPUHQURA-UHFFFAOYSA-N 382611 US10273259, Example 320::US10711020, Example 320 Nuclear receptor ROR-gamma [262-507] 333 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382611 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382611&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679117 404851968 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931233 OC(=O)C1CC2(C1)CC(C2)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1cccc(F)c1 InChI=1S/C30H27F8NO5S/c31-20-2-1-3-21(11-20)45(43,44)27-8-9-39(24(40)17-12-26(13-17)14-18(15-26)25(41)42)23(27)7-4-16-10-19(5-6-22(16)27)28(32,29(33,34)35)30(36,37)38/h1-3,5-6,10-11,17-18,23H,4,7-9,12-15H2,(H,41,42) KYPLGCNUBPIZLF-UHFFFAOYSA-N 453358 US10711020, Example 321 Nuclear receptor ROR-gamma [262-507] 81.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=453358 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=453358&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678540 440969277 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931234 OC(=O)c1ccc(cc1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C29H21F8NO5S/c30-20-7-9-21(10-8-20)44(42,43)26-13-14-38(24(39)16-1-3-17(4-2-16)25(40)41)23(26)12-5-18-15-19(6-11-22(18)26)27(31,28(32,33)34)29(35,36)37/h1-4,6-11,15,23H,5,12-14H2,(H,40,41)/t23-,26-/m1/s1 ZKAXALRFUNLGET-ZEQKJWHPSA-N 382613 US10273259, Example 322::US10711020, Example 322 Nuclear receptor ROR-gamma [262-507] 74.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382613 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382613&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679105 404851970 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931235 OC(=O)C1CCC(C1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H25F8NO5S/c29-19-5-7-20(8-6-19)43(41,42)25-11-12-37(23(38)16-1-2-17(13-16)24(39)40)22(25)10-3-15-14-18(4-9-21(15)25)26(30,27(31,32)33)28(34,35)36/h4-9,14,16-17,22H,1-3,10-13H2,(H,39,40)/t16?,17?,22-,25-/m1/s1 XRRXYBCURUVMRW-AZNPCEPYSA-N 382614 US10273259, Example 323::US10711020, Example 323 Nuclear receptor ROR-gamma [262-507] 125 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382614 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382614&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678527 404851971 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931236 OC(=O)c1cnc(cn1)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1cccc(F)c1 InChI=1S/C27H19F8N3O5S/c28-16-2-1-3-17(11-16)44(42,43)24-8-9-38(22(39)19-12-37-20(13-36-19)23(40)41)21(24)7-4-14-10-15(5-6-18(14)24)25(29,26(30,31)32)27(33,34)35/h1-3,5-6,10-13,21H,4,7-9H2,(H,40,41) FDAQVIWZIHQLPI-UHFFFAOYSA-N 382615 US10273259, Example 324::US10711020, Example 324 Nuclear receptor ROR-gamma [262-507] 128 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382615 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382615&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678505 404851972 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931237 Cc1cc(cc(c1)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1cccc(F)c1)C(O)=O InChI=1S/C30H23F8NO5S/c1-16-11-18(13-19(12-16)26(41)42)25(40)39-10-9-27(45(43,44)22-4-2-3-21(31)15-22)23-7-6-20(14-17(23)5-8-24(27)39)28(32,29(33,34)35)30(36,37)38/h2-4,6-7,11-15,24H,5,8-10H2,1H3,(H,41,42) DWXDIERSXAHUBC-UHFFFAOYSA-N 382616 US10273259, Example 325::US10711020, Example 325 Nuclear receptor ROR-gamma [262-507] 152 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382616 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382616&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679093 404851973 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931238 OC(=O)C1CC2(C1)CC(C2)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C30H27F8NO5S/c31-20-3-5-21(6-4-20)45(43,44)27-9-10-39(24(40)17-12-26(13-17)14-18(15-26)25(41)42)23(27)8-1-16-11-19(2-7-22(16)27)28(32,29(33,34)35)30(36,37)38/h2-7,11,17-18,23H,1,8-10,12-15H2,(H,41,42)/t17?,18?,23-,26?,27-/m1/s1 UPWOYPBEIAJQBZ-CRDIYBEASA-N 453363 US10711020, Example 326 Nuclear receptor ROR-gamma [262-507] 128 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=453363 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=453363&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678649 440969278 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931239 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)c1ccc(cc1)-c1nnco1 InChI=1S/C30H21F8N3O4S/c31-21-7-9-22(10-8-21)46(43,44)27-13-14-41(26(42)18-3-1-17(2-4-18)25-40-39-16-45-25)24(27)12-5-19-15-20(6-11-23(19)27)28(32,29(33,34)35)30(36,37)38/h1-4,6-11,15-16,24H,5,12-14H2/t24-,27-/m1/s1 HVZIZFONULYDJA-SHQCIBLASA-N 382618 US10273259, Example 327::US10711020, Example 327 Nuclear receptor ROR-gamma [262-507] 82.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382618 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382618&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678734 404851975 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931240 OCc1ccc(cc1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C29H23F8NO4S/c30-21-7-9-22(10-8-21)43(41,42)26-13-14-38(25(40)18-3-1-17(16-39)2-4-18)24(26)12-5-19-15-20(6-11-23(19)26)27(31,28(32,33)34)29(35,36)37/h1-4,6-11,15,24,39H,5,12-14,16H2/t24-,26-/m1/s1 XLQOBXBSKGJKGF-AOYPEHQESA-N 382619 US10273259, Example 328::US10711020, Example 328 Nuclear receptor ROR-gamma [262-507] 54.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382619 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382619&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678633 404851976 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931241 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)c1ccc(cc1)-c1nn[nH]n1 382620 US10273259, Example 329::US10711020, Example 329 Nuclear receptor ROR-gamma [262-507] 62.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382620 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382620&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678695 404851977 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931242 NS(=O)(=O)c1ccc(cc1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H22F8N2O5S2/c29-19-5-9-20(10-6-19)44(40,41)25-13-14-38(24(39)16-1-7-21(8-2-16)45(37,42)43)23(25)12-3-17-15-18(4-11-22(17)25)26(30,27(31,32)33)28(34,35)36/h1-2,4-11,15,23H,3,12-14H2,(H2,37,42,43)/t23-,25-/m1/s1 WMCHBRMNHFQGED-ILBGXUMGSA-N 382621 US10273259, Example 330::US10711020, Example 330 Nuclear receptor ROR-gamma [262-507] 115 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382621 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382621&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679102 404851978 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931243 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)Cc1ccncc1 InChI=1S/C28H22F8N2O3S/c29-20-3-5-21(6-4-20)42(40,41)25-11-14-38(24(39)15-17-9-12-37-13-10-17)23(25)8-1-18-16-19(2-7-22(18)25)26(30,27(31,32)33)28(34,35)36/h2-7,9-10,12-13,16,23H,1,8,11,14-15H2/t23-,25-/m1/s1 SEDSNSRRZRDDNP-ILBGXUMGSA-N 382622 US10273259, Example 331::US10711020, Example 331 Nuclear receptor ROR-gamma [262-507] 54.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382622 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382622&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679108 404851979 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931244 OC(=O)c1ccc(cc1)S(=O)(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H21F8NO6S2/c29-19-5-9-20(10-6-19)44(40,41)25-13-14-37(45(42,43)21-7-1-16(2-8-21)24(38)39)23(25)12-3-17-15-18(4-11-22(17)25)26(30,27(31,32)33)28(34,35)36/h1-2,4-11,15,23H,3,12-14H2,(H,38,39)/t23-,25-/m1/s1 SEXUZVDOMNAALM-ILBGXUMGSA-N 382623 US10273259, Example 332::US10711020, Example 332 Nuclear receptor ROR-gamma [262-507] 121 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382623 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382623&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678868 404851980 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931245 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)Cc1cncnc1 InChI=1S/C27H21F8N3O3S/c28-19-3-5-20(6-4-19)42(40,41)24-9-10-38(23(39)11-16-13-36-15-37-14-16)22(24)8-1-17-12-18(2-7-21(17)24)25(29,26(30,31)32)27(33,34)35/h2-7,12-15,22H,1,8-11H2/t22-,24-/m1/s1 LEKQDPRYEBJVIH-ISKFKSNPSA-N 382624 US10273259, Example 333::US10711020, Example 333 Nuclear receptor ROR-gamma [262-507] 88.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382624 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382624&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678845 404851981 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931246 NS(=O)(=O)c1cc(ccc1Cl)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H21ClF8N2O5S2/c29-21-9-1-16(14-22(21)46(38,43)44)24(40)39-12-11-25(45(41,42)19-6-4-18(30)5-7-19)20-8-3-17(13-15(20)2-10-23(25)39)26(31,27(32,33)34)28(35,36)37/h1,3-9,13-14,23H,2,10-12H2,(H2,38,43,44)/t23-,25-/m1/s1 RPNHVVAALQLNOB-ILBGXUMGSA-N 382625 US10273259, Example 334::US10711020, Example 334 Nuclear receptor ROR-gamma [262-507] 41.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382625 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382625&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678821 404851982 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931247 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)c1ccc2C(=O)NCc2c1 InChI=1S/C30H22F8N2O4S/c31-20-4-6-21(7-5-20)45(43,44)27-11-12-40(26(42)17-1-8-22-18(13-17)15-39-25(22)41)24(27)10-2-16-14-19(3-9-23(16)27)28(32,29(33,34)35)30(36,37)38/h1,3-9,13-14,24H,2,10-12,15H2,(H,39,41)/t24-,27-/m1/s1 UBTUPRGYKVUASL-SHQCIBLASA-N 382626 US10273259, Example 335::US10711020, Example 335 Nuclear receptor ROR-gamma [262-507] 140 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382626 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382626&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678603 404851983 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931248 NS(=O)(=O)c1cccc(c1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H22F8N2O5S2/c29-19-6-8-20(9-7-19)44(40,41)25-12-13-38(24(39)17-2-1-3-21(15-17)45(37,42)43)23(25)11-4-16-14-18(5-10-22(16)25)26(30,27(31,32)33)28(34,35)36/h1-3,5-10,14-15,23H,4,11-13H2,(H2,37,42,43)/t23-,25-/m1/s1 NWFBAZUHPGTJHC-ILBGXUMGSA-N 382627 US10273259, Example 336::US10711020, Example 336 Nuclear receptor ROR-gamma [262-507] 119 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382627 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382627&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678626 404851984 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931249 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)c1ccc2NC(=O)Cc2c1 InChI=1S/C30H22F8N2O4S/c31-20-4-6-21(7-5-20)45(43,44)27-11-12-40(26(42)17-1-9-23-18(13-17)15-25(41)39-23)24(27)10-2-16-14-19(3-8-22(16)27)28(32,29(33,34)35)30(36,37)38/h1,3-9,13-14,24H,2,10-12,15H2,(H,39,41)/t24-,27-/m1/s1 HVAGBVYVAFXHLT-SHQCIBLASA-N 382628 US10273259, Example 337::US10711020, Example 337 Nuclear receptor ROR-gamma [262-507] 186 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382628 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382628&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678993 404851985 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931250 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)c1ccc2[nH]cnc2c1 382629 US10273259, Example 338::US10711020, Example 338 Nuclear receptor ROR-gamma [262-507] 239 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382629 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382629&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678728 404851986 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931251 OC(=O)c1cc(cc(c1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1)C(O)=O InChI=1S/C30H21F8NO7S/c31-20-3-5-21(6-4-20)47(45,46)27-9-10-39(24(40)16-11-17(25(41)42)13-18(12-16)26(43)44)23(27)8-1-15-14-19(2-7-22(15)27)28(32,29(33,34)35)30(36,37)38/h2-7,11-14,23H,1,8-10H2,(H,41,42)(H,43,44)/t23-,27-/m1/s1 KENMFEAXPXMJJS-YIXXDRMTSA-N 382630 US10273259, Example 339::US10711020, Example 339 Nuclear receptor ROR-gamma [262-507] 197 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382630 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382630&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678732 404851987 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931252 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)c1ccc2NC(=O)COc2c1 InChI=1S/C30H22F8N2O5S/c31-19-4-6-20(7-5-19)46(43,44)27-11-12-40(26(42)17-1-9-22-23(14-17)45-15-25(41)39-22)24(27)10-2-16-13-18(3-8-21(16)27)28(32,29(33,34)35)30(36,37)38/h1,3-9,13-14,24H,2,10-12,15H2,(H,39,41)/t24-,27-/m1/s1 PNAROIQEGCCOSJ-SHQCIBLASA-N 382631 US10273259, Example 340::US10711020, Example 340 Nuclear receptor ROR-gamma [262-507] 37.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382631 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382631&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679125 404851988 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931253 OC(=O)C1CC2(C1)CC(C2)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccccc1 InChI=1S/C30H28F7NO5S/c31-28(29(32,33)34,30(35,36)37)20-7-8-22-17(12-20)6-9-23-27(22,44(42,43)21-4-2-1-3-5-21)10-11-38(23)24(39)18-13-26(14-18)15-19(16-26)25(40)41/h1-5,7-8,12,18-19,23H,6,9-11,13-16H2,(H,40,41)/t18?,19?,23-,26?,27-/m1/s1 WOJBGBRWZMNGRI-YTJHPHSKSA-N 453378 US10711020, Example 341 Nuclear receptor ROR-gamma [262-507] 44.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=453378 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=453378&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678519 440969282 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931254 OC(=O)c1ccc(cc1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccccc1 InChI=1S/C29H22F7NO5S/c30-27(28(31,32)33,29(34,35)36)20-11-12-22-19(16-20)10-13-23-26(22,43(41,42)21-4-2-1-3-5-21)14-15-37(23)24(38)17-6-8-18(9-7-17)25(39)40/h1-9,11-12,16,23H,10,13-15H2,(H,39,40)/t23-,26-/m1/s1 USKRCYFWVMZWRP-ZEQKJWHPSA-N 382633 US10273259, Example 342::US10711020, Example 342 Nuclear receptor ROR-gamma [262-507] 119 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382633 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382633&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678999 404851990 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931255 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)c1ccc2c(c1)C(=O)NS2(=O)=O InChI=1S/C29H20F8N2O6S2/c30-18-4-6-19(7-5-18)46(42,43)26-11-12-39(25(41)16-1-9-22-20(14-16)24(40)38-47(22,44)45)23(26)10-2-15-13-17(3-8-21(15)26)27(31,28(32,33)34)29(35,36)37/h1,3-9,13-14,23H,2,10-12H2,(H,38,40)/t23-,26-/m1/s1 YOVDSGAMTHRXTK-ZEQKJWHPSA-N 382634 US10273259, Example 343::US10711020, Example 343 Nuclear receptor ROR-gamma [262-507] 106 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382634 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382634&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678863 404851991 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931256 OC(=O)c1cc(Cl)c(cc1Cl)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C29H19Cl2F8NO5S/c30-21-13-19(25(42)43)22(31)12-18(21)24(41)40-10-9-26(46(44,45)17-5-3-16(32)4-6-17)20-7-2-15(11-14(20)1-8-23(26)40)27(33,28(34,35)36)29(37,38)39/h2-7,11-13,23H,1,8-10H2,(H,42,43)/t23-,26-/m1/s1 FXAFXCOGEVHGHY-ZEQKJWHPSA-N 382635 US10273259, Example 344::US10711020, Example 344 Nuclear receptor ROR-gamma [262-507] 10.00 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382635 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382635&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678982 404851992 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931257 NC(=O)c1ccc(cc1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C29H22F8N2O4S/c30-20-7-9-21(10-8-20)44(42,43)26-13-14-39(25(41)17-3-1-16(2-4-17)24(38)40)23(26)12-5-18-15-19(6-11-22(18)26)27(31,28(32,33)34)29(35,36)37/h1-4,6-11,15,23H,5,12-14H2,(H2,38,40)/t23-,26-/m1/s1 LQUHSHQSUFRMIQ-ZEQKJWHPSA-N 382636 US10273259, Example 345::US10711020, Example 345 Nuclear receptor ROR-gamma [262-507] 22.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382636 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382636&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679112 404851993 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931258 NC(=O)c1ccc(C(=O)N2CC[C@@]3([C@H]2CCc2cc(ccc32)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c2ccc(F)cc2)c(F)c1 InChI=1S/C29H21F9N2O4S/c30-18-4-6-19(7-5-18)45(43,44)26-11-12-40(25(42)20-8-1-16(24(39)41)14-22(20)31)23(26)10-2-15-13-17(3-9-21(15)26)27(32,28(33,34)35)29(36,37)38/h1,3-9,13-14,23H,2,10-12H2,(H2,39,41)/t23-,26-/m1/s1 MDWYXKVEAFUDBW-ZEQKJWHPSA-N 382637 US10273259, Example 346::US10711020, Example 346 Nuclear receptor ROR-gamma [262-507] 78.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382637 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382637&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678729 404851994 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931259 OC(=O)C1CCCC(C1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C29H27F8NO5S/c30-20-6-8-21(9-7-20)44(42,43)26-12-13-38(24(39)17-2-1-3-18(14-17)25(40)41)23(26)11-4-16-15-19(5-10-22(16)26)27(31,28(32,33)34)29(35,36)37/h5-10,15,17-18,23H,1-4,11-14H2,(H,40,41)/t17?,18?,23-,26-/m1/s1 FWTGORCOGNNJLR-OYUWVLQBSA-N 382638 US10273259, Example 347::US10273259, Example 348::US10711020, Example 348 Nuclear receptor ROR-gamma [262-507] 5.00 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382638 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382638&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 132123319 404851995 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931260 OC(=O)C1CCCC(C1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C29H27F8NO5S/c30-20-6-8-21(9-7-20)44(42,43)26-12-13-38(24(39)17-2-1-3-18(14-17)25(40)41)23(26)11-4-16-15-19(5-10-22(16)26)27(31,28(32,33)34)29(35,36)37/h5-10,15,17-18,23H,1-4,11-14H2,(H,40,41)/t17?,18?,23-,26-/m1/s1 FWTGORCOGNNJLR-OYUWVLQBSA-N 382638 US10273259, Example 347::US10273259, Example 348::US10711020, Example 348 Nuclear receptor ROR-gamma [262-507] 34.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382638 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382638&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 132123319 404851995 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931261 OC(=O)c1cc(O)c(cc1O)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C29H21F8NO7S/c30-16-3-5-17(6-4-16)46(44,45)26-9-10-38(24(41)18-12-22(40)19(25(42)43)13-21(18)39)23(26)8-1-14-11-15(2-7-20(14)26)27(31,28(32,33)34)29(35,36)37/h2-7,11-13,23,39-40H,1,8-10H2,(H,42,43)/t23-,26-/m1/s1 MXEIMENGTNBDPI-ZEQKJWHPSA-N 382640 US10273259, Example 349::US10711020, Example 349 Nuclear receptor ROR-gamma [262-507] 601 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382640 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382640&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679115 404851996 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931262 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1CCCCC1 InChI=1S/C28H27F8NO3S/c29-20-8-10-21(11-9-20)41(39,40)25-14-15-37(24(38)17-4-2-1-3-5-17)23(25)13-6-18-16-19(7-12-22(18)25)26(30,27(31,32)33)28(34,35)36/h7-12,16-17,23H,1-6,13-15H2/t23-,25-/m1/s1 JAQLPAODRGTVQT-ILBGXUMGSA-N 382641 US10273259, Example 350::US10711020, Example 350 Nuclear receptor ROR-gamma [262-507] 240 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382641 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382641&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678913 404851997 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931263 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)c1ccccc1 InChI=1S/C28H21F8NO3S/c29-20-8-10-21(11-9-20)41(39,40)25-14-15-37(24(38)17-4-2-1-3-5-17)23(25)13-6-18-16-19(7-12-22(18)25)26(30,27(31,32)33)28(34,35)36/h1-5,7-12,16,23H,6,13-15H2/t23-,25-/m1/s1 JVLYDNYXTISUKO-ILBGXUMGSA-N 382642 US10273259, Example 351::US10711020, Example 351 Nuclear receptor ROR-gamma [262-507] 85.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382642 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382642&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678628 404851998 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931264 NC(=O)c1cccc(c1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C29H22F8N2O4S/c30-20-6-8-21(9-7-20)44(42,43)26-12-13-39(25(41)18-3-1-2-17(14-18)24(38)40)23(26)11-4-16-15-19(5-10-22(16)26)27(31,28(32,33)34)29(35,36)37/h1-3,5-10,14-15,23H,4,11-13H2,(H2,38,40)/t23-,26-/m1/s1 MOZRISUTSMGOOS-ZEQKJWHPSA-N 382643 US10273259, Example 352::US10711020, Example 352 Nuclear receptor ROR-gamma [262-507] 96.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382643 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382643&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678719 404851999 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931265 Cn1ccc(cc1=O)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H22F8N2O4S/c1-37-12-10-17(15-23(37)39)24(40)38-13-11-25(43(41,42)20-6-4-19(29)5-7-20)21-8-3-18(14-16(21)2-9-22(25)38)26(30,27(31,32)33)28(34,35)36/h3-8,10,12,14-15,22H,2,9,11,13H2,1H3/t22-,25-/m1/s1 SIVXBFINULJZLY-RCZVLFRGSA-N 382644 US10273259, Example 353::US10711020, Example 353 Nuclear receptor ROR-gamma [262-507] 953 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382644 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382644&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679118 404852000 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931266 Cn1cc(ccc1=O)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H22F8N2O4S/c1-37-15-17(3-11-23(37)39)24(40)38-13-12-25(43(41,42)20-7-5-19(29)6-8-20)21-9-4-18(14-16(21)2-10-22(25)38)26(30,27(31,32)33)28(34,35)36/h3-9,11,14-15,22H,2,10,12-13H2,1H3/t22-,25-/m1/s1 OVTLIBRJQHFICL-RCZVLFRGSA-N 382645 US10273259, Example 354::US10711020, Example 354 Nuclear receptor ROR-gamma [262-507] 230 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382645 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382645&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678500 404852001 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931267 O[C@H]1CC[C@@H](CC1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H27F8NO4S/c29-19-5-9-21(10-6-19)42(40,41)25-13-14-37(24(39)16-1-7-20(38)8-2-16)23(25)12-3-17-15-18(4-11-22(17)25)26(30,27(31,32)33)28(34,35)36/h4-6,9-11,15-16,20,23,38H,1-3,7-8,12-14H2/t16-,20-,23-,25-/m1/s1 CZOAKRDFNBPBNH-STHMRSITSA-N 382646 US10273259, Example 355::US10711020, Example 355 Nuclear receptor ROR-gamma [262-507] 285 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382646 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382646&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678619 404852002 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931268 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1CCC2(CC1)NC(=O)NC2=O InChI=1S/C30H27F8N3O5S/c31-19-3-5-20(6-4-19)47(45,46)27-13-14-41(23(42)16-9-11-26(12-10-16)24(43)39-25(44)40-26)22(27)8-1-17-15-18(2-7-21(17)27)28(32,29(33,34)35)30(36,37)38/h2-7,15-16,22H,1,8-14H2,(H2,39,40,43,44)/t16?,22-,26?,27-/m1/s1 SBVRHUOLSBTQLX-UHFDNVQUSA-N 453393 US10711020, Example 356 Nuclear receptor ROR-gamma [262-507] 266 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=453393 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=453393&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679009 440969297 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931269 OC(=O)C1CC2(C1)CC(C2)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C30H27F8NO5S/c31-20-3-5-21(6-4-20)45(43,44)27-9-10-39(24(40)17-12-26(13-17)14-18(15-26)25(41)42)23(27)8-1-16-11-19(2-7-22(16)27)28(32,29(33,34)35)30(36,37)38/h2-7,11,17-18,23H,1,8-10,12-15H2,(H,41,42)/t17?,18?,23-,26?,27-/m1/s1 UPWOYPBEIAJQBZ-CRDIYBEASA-N 382617 US10273259, Example 326::US10711020, Example 358 Nuclear receptor ROR-gamma [262-507] 104 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382617 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382617&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678649 404851974 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931270 OC(=O)C1CC2(C1)CC(C2)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C30H27F8NO5S/c31-20-3-5-21(6-4-20)45(43,44)27-9-10-39(24(40)17-12-26(13-17)14-18(15-26)25(41)42)23(27)8-1-16-11-19(2-7-22(16)27)28(32,29(33,34)35)30(36,37)38/h2-7,11,17-18,23H,1,8-10,12-15H2,(H,41,42)/t17?,18?,23-,26?,27-/m1/s1 UPWOYPBEIAJQBZ-CRDIYBEASA-N 382617 US10273259, Example 326::US10711020, Example 358 Nuclear receptor ROR-gamma [262-507] 136 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382617 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382617&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678649 404851974 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931271 Fc1ccc(cc1)S(=O)(=O)C12CCN(C1COc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1CCC2(CC1)NC(=O)NC2=O InChI=1S/C29H25F8N3O6S/c30-17-2-4-18(5-3-17)47(44,45)26-11-12-40(22(41)15-7-9-25(10-8-15)23(42)38-24(43)39-25)21(26)14-46-20-13-16(1-6-19(20)26)27(31,28(32,33)34)29(35,36)37/h1-6,13,15,21H,7-12,14H2,(H2,38,39,42,43) SGTGAONQNSKSPX-UHFFFAOYSA-N 382650 US10273259, Example 359::US10273259, Example 360::US10711020, Example 360 Nuclear receptor ROR-gamma [262-507] 130 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382650 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382650&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678739 404852006 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931272 Fc1ccc(cc1)S(=O)(=O)C12CCN(C1COc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1CCC2(CC1)NC(=O)NC2=O InChI=1S/C29H25F8N3O6S/c30-17-2-4-18(5-3-17)47(44,45)26-11-12-40(22(41)15-7-9-25(10-8-15)23(42)38-24(43)39-25)21(26)14-46-20-13-16(1-6-19(20)26)27(31,28(32,33)34)29(35,36)37/h1-6,13,15,21H,7-12,14H2,(H2,38,39,42,43) SGTGAONQNSKSPX-UHFFFAOYSA-N 382650 US10273259, Example 359::US10273259, Example 360::US10711020, Example 360 Nuclear receptor ROR-gamma [262-507] 77.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382650 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382650&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678739 404852006 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931273 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)[C@H]1CC[C@@H](CC1)c1nnn[nH]1 382652 US10273259, Example 361::US10711020, Example 361 Nuclear receptor ROR-gamma [262-507] 46.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382652 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382652&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679104 404852007 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931274 CS(=O)(=O)c1ccc(cc1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C29H23F8NO5S2/c1-44(40,41)21-8-2-17(3-9-21)25(39)38-15-14-26(45(42,43)22-10-6-20(30)7-11-22)23-12-5-19(16-18(23)4-13-24(26)38)27(31,28(32,33)34)29(35,36)37/h2-3,5-12,16,24H,4,13-15H2,1H3/t24-,26-/m1/s1 UWJXXUWARUDOHU-AOYPEHQESA-N 382653 US10273259, Example 362::US10711020, Example 362 Nuclear receptor ROR-gamma [262-507] 47.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382653 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382653&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678516 404852008 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931275 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)CC1CCS(=O)(=O)C1 InChI=1S/C27H25F8NO5S2/c28-19-3-5-20(6-4-19)43(40,41)24-10-11-36(23(37)13-16-9-12-42(38,39)15-16)22(24)8-1-17-14-18(2-7-21(17)24)25(29,26(30,31)32)27(33,34)35/h2-7,14,16,22H,1,8-13,15H2/t16?,22-,24-/m1/s1 UCYZQOKQNNPHCL-QOPVDAPCSA-N 382654 US10273259, Example 363::US10711020, Example 363 Nuclear receptor ROR-gamma [262-507] 12.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382654 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382654&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678920 404852009 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931276 CC(=O)N1CC(C1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C27H24F8N2O4S/c1-15(38)36-13-17(14-36)23(39)37-11-10-24(42(40,41)20-6-4-19(28)5-7-20)21-8-3-18(12-16(21)2-9-22(24)37)25(29,26(30,31)32)27(33,34)35/h3-8,12,17,22H,2,9-11,13-14H2,1H3/t22-,24-/m1/s1 GCLHWQFHIDGCFL-ISKFKSNPSA-N 382655 US10273259, Example 364::US10711020, Example 364 Nuclear receptor ROR-gamma [262-507] 20.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382655 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382655&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678967 404852010 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931277 CS(=O)(=O)N1CCC(CC1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H28F8N2O5S2/c1-44(40,41)37-13-10-17(11-14-37)24(39)38-15-12-25(45(42,43)21-6-4-20(29)5-7-21)22-8-3-19(16-18(22)2-9-23(25)38)26(30,27(31,32)33)28(34,35)36/h3-8,16-17,23H,2,9-15H2,1H3/t23-,25-/m1/s1 VEYOQDOVAYUNHR-ILBGXUMGSA-N 382656 US10273259, Example 365::US10711020, Example 365 Nuclear receptor ROR-gamma [262-507] 35.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382656 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382656&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678985 404852011 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931278 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)CC1CCS(=O)(=O)C1 InChI=1S/C27H25F8NO5S2/c28-19-3-5-20(6-4-19)43(40,41)24-10-11-36(23(37)13-16-9-12-42(38,39)15-16)22(24)8-1-17-14-18(2-7-21(17)24)25(29,26(30,31)32)27(33,34)35/h2-7,14,16,22H,1,8-13,15H2/t16?,22-,24-/m1/s1 UCYZQOKQNNPHCL-QOPVDAPCSA-N 382657 US10273259, Example 366::US10273259, Example 367::US10711020, Example 367 Nuclear receptor ROR-gamma [262-507] 35.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382657 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382657&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678920 404852012 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931279 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)CC1CCS(=O)(=O)C1 InChI=1S/C27H25F8NO5S2/c28-19-3-5-20(6-4-19)43(40,41)24-10-11-36(23(37)13-16-9-12-42(38,39)15-16)22(24)8-1-17-14-18(2-7-21(17)24)25(29,26(30,31)32)27(33,34)35/h2-7,14,16,22H,1,8-13,15H2/t16?,22-,24-/m1/s1 UCYZQOKQNNPHCL-QOPVDAPCSA-N 382657 US10273259, Example 366::US10273259, Example 367::US10711020, Example 367 Nuclear receptor ROR-gamma [262-507] 62.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382657 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382657&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678920 404852012 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931280 CS(=O)(=O)N1CCC(CC1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccccc1 InChI=1S/C28H29F7N2O5S2/c1-43(39,40)36-14-11-18(12-15-36)24(38)37-16-13-25(44(41,42)21-5-3-2-4-6-21)22-9-8-20(17-19(22)7-10-23(25)37)26(29,27(30,31)32)28(33,34)35/h2-6,8-9,17-18,23H,7,10-16H2,1H3/t23-,25-/m1/s1 GJNHXNRJADDQTA-ILBGXUMGSA-N 382659 US10273259, Example 368::US10711020, Example 368 Nuclear receptor ROR-gamma [262-507] 24.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382659 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382659&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679004 404852013 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931281 Cc1cc(ccc1F)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1CCN(CC1)S(C)(=O)=O InChI=1S/C29H30F8N2O5S2/c1-17-15-21(5-7-23(17)30)46(43,44)26-11-14-39(25(40)18-9-12-38(13-10-18)45(2,41)42)24(26)8-3-19-16-20(4-6-22(19)26)27(31,28(32,33)34)29(35,36)37/h4-7,15-16,18,24H,3,8-14H2,1-2H3 ZNTDQSZSJDSAST-UHFFFAOYSA-N 382660 US10273259, Example 369::US10711020, Example 369 Nuclear receptor ROR-gamma [262-507] 35.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382660 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382660&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678524 404852014 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931282 CS(=O)(=O)N1CCC(CC1)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1cccc(F)c1 InChI=1S/C28H28F8N2O5S2/c1-44(40,41)37-12-9-17(10-13-37)24(39)38-14-11-25(45(42,43)21-4-2-3-20(29)16-21)22-7-6-19(15-18(22)5-8-23(25)38)26(30,27(31,32)33)28(34,35)36/h2-4,6-7,15-17,23H,5,8-14H2,1H3 REHJUZSIENCEGO-UHFFFAOYSA-N 382661 US10273259, Example 370::US10711020, Example 370 Nuclear receptor ROR-gamma [262-507] 35.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382661 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382661&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679141 404852015 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931283 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)c1ccc(cc1)-n1cnnn1 InChI=1S/C29H21F8N5O3S/c30-20-5-9-22(10-6-20)46(44,45)26-13-14-41(25(43)17-1-7-21(8-2-17)42-16-38-39-40-42)24(26)12-3-18-15-19(4-11-23(18)26)27(31,28(32,33)34)29(35,36)37/h1-2,4-11,15-16,24H,3,12-14H2/t24-,26-/m1/s1 ALTLNQMAVJRFDW-AOYPEHQESA-N 382662 US10273259, Example 371::US10711020, Example 371 Nuclear receptor ROR-gamma [262-507] 109 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382662 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382662&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678853 404852016 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931284 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)c1ccc(cc1)C#N InChI=1S/C29H20F8N2O3S/c30-21-7-9-22(10-8-21)43(41,42)26-13-14-39(25(40)18-3-1-17(16-38)2-4-18)24(26)12-5-19-15-20(6-11-23(19)26)27(31,28(32,33)34)29(35,36)37/h1-4,6-11,15,24H,5,12-14H2/t24-,26-/m1/s1 PSJUQUWQRJEGSX-AOYPEHQESA-N 382663 US10273259, Example 372::US10711020, Example 372 Nuclear receptor ROR-gamma [262-507] 161 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382663 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382663&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678914 404852017 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931285 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)CC1CCS(=O)(=O)CC1 InChI=1S/C28H27F8NO5S2/c29-20-3-5-21(6-4-20)44(41,42)25-11-12-37(24(38)15-17-9-13-43(39,40)14-10-17)23(25)8-1-18-16-19(2-7-22(18)25)26(30,27(31,32)33)28(34,35)36/h2-7,16-17,23H,1,8-15H2/t23-,25-/m1/s1 YHSUVAQNZOATEZ-ILBGXUMGSA-N 382664 US10273259, Example 373::US10711020, Example 373 Nuclear receptor ROR-gamma [262-507] 55.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382664 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382664&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678928 404852018 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931286 FC(F)(F)C(F)(c1ccc2c(OCC3N(CCC23S(=O)(=O)c2ccccc2)C(=O)CC2CCS(=O)(=O)CC2)c1)C(F)(F)F InChI=1S/C27H26F7NO6S2/c28-25(26(29,30)31,27(32,33)34)18-6-7-20-21(15-18)41-16-22-24(20,43(39,40)19-4-2-1-3-5-19)10-11-35(22)23(36)14-17-8-12-42(37,38)13-9-17/h1-7,15,17,22H,8-14,16H2 FPLSYMMKDGXYBR-UHFFFAOYSA-N 382665 US10273259, Example 374::US10711020, Example 374 Nuclear receptor ROR-gamma [262-507] 58.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382665 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382665&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678730 404852019 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931287 CC(=O)N1CCC(CC1C(O)=O)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C30H28F8N2O6S/c1-16(41)39-12-10-18(15-23(39)26(43)44)25(42)40-13-11-27(47(45,46)21-6-4-20(31)5-7-21)22-8-3-19(14-17(22)2-9-24(27)40)28(32,29(33,34)35)30(36,37)38/h3-8,14,18,23-24H,2,9-13,15H2,1H3,(H,43,44)/t18?,23?,24-,27-/m1/s1 BMMOWNJBCYQWAL-OBTYJLIHSA-N 382666 US10273259, Example 375::US10711020, Example 375 Nuclear receptor ROR-gamma [262-507] 60.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382666 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382666&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679136 404852020 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931288 OC(=O)c1cc(ccc1Cl)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C29H20ClF8NO5S/c30-22-9-1-16(14-20(22)25(41)42)24(40)39-12-11-26(45(43,44)19-6-4-18(31)5-7-19)21-8-3-17(13-15(21)2-10-23(26)39)27(32,28(33,34)35)29(36,37)38/h1,3-9,13-14,23H,2,10-12H2,(H,41,42)/t23-,26-/m1/s1 PRJIYEFFGGSXHE-ZEQKJWHPSA-N 382667 US10273259, Example 376::US10711020, Example 376 Nuclear receptor ROR-gamma [262-507] 255 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382667 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382667&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678632 404852021 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931289 COc1ccc(cc1C#N)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C30H22F8N2O4S/c1-44-24-10-2-18(14-19(24)16-39)26(41)40-13-12-27(45(42,43)22-7-5-21(31)6-8-22)23-9-4-20(15-17(23)3-11-25(27)40)28(32,29(33,34)35)30(36,37)38/h2,4-10,14-15,25H,3,11-13H2,1H3/t25-,27-/m1/s1 KOVISBJEYKJXRE-XNMGPUDCSA-N 382668 US10273259, Example 377::US10711020, Example 377 Nuclear receptor ROR-gamma [262-507] 628 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382668 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382668&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678624 404852022 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931290 Oc1c(F)cc(cc1F)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H19F10NO4S/c29-17-3-5-18(6-4-17)44(42,43)25-9-10-39(24(41)15-12-20(30)23(40)21(31)13-15)22(25)8-1-14-11-16(2-7-19(14)25)26(32,27(33,34)35)28(36,37)38/h2-7,11-13,22,40H,1,8-10H2/t22-,25-/m1/s1 INIUSJJUSRBSBN-RCZVLFRGSA-N 382669 US10273259, Example 378::US10711020, Example 378 Nuclear receptor ROR-gamma [262-507] 72.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382669 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382669&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678918 404852023 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931291 OC(=O)c1c(F)cc(cc1F)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C29H19F10NO5S/c30-17-3-5-18(6-4-17)46(44,45)26-9-10-40(24(41)15-12-20(31)23(25(42)43)21(32)13-15)22(26)8-1-14-11-16(2-7-19(14)26)27(33,28(34,35)36)29(37,38)39/h2-7,11-13,22H,1,8-10H2,(H,42,43)/t22-,26-/m1/s1 VYUYFJSMSPSIIO-ATIYNZHBSA-N 382670 US10273259, Example 379::US10711020, Example 379 Nuclear receptor ROR-gamma [262-507] 55.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382670 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382670&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678867 404852024 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931292 CC(=O)N1CCC(CO)(CC1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C30H30F8N2O5S/c1-18(42)39-13-10-26(17-41,11-14-39)25(43)40-15-12-27(46(44,45)22-6-4-21(31)5-7-22)23-8-3-20(16-19(23)2-9-24(27)40)28(32,29(33,34)35)30(36,37)38/h3-8,16,24,41H,2,9-15,17H2,1H3/t24-,27-/m1/s1 WXVJDKALKJHVLF-SHQCIBLASA-N 382671 US10273259, Example 380::US10711020, Example 380 Nuclear receptor ROR-gamma [262-507] 36.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382671 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382671&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678640 404852025 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931293 CC(=O)N1CC(CC(=O)N2CC[C@@]3([C@H]2CCc2cc(ccc32)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c2ccc(F)cc2)C1 InChI=1S/C28H26F8N2O4S/c1-16(39)37-14-17(15-37)12-24(40)38-11-10-25(43(41,42)21-6-4-20(29)5-7-21)22-8-3-19(13-18(22)2-9-23(25)38)26(30,27(31,32)33)28(34,35)36/h3-8,13,17,23H,2,9-12,14-15H2,1H3/t23-,25-/m1/s1 OAAYOFOYFQMJKB-ILBGXUMGSA-N 382672 US10273259, Example 381::US10711020, Example 381 Nuclear receptor ROR-gamma [262-507] 89.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382672 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382672&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678648 404852026 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931294 CS(=O)(=O)N1CC(CC(=O)N2CC[C@@]3([C@H]2CCc2cc(ccc32)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c2ccc(F)cc2)C1 InChI=1S/C27H26F8N2O5S2/c1-43(39,40)36-14-16(15-36)12-23(38)37-11-10-24(44(41,42)20-6-4-19(28)5-7-20)21-8-3-18(13-17(21)2-9-22(24)37)25(29,26(30,31)32)27(33,34)35/h3-8,13,16,22H,2,9-12,14-15H2,1H3/t22-,24-/m1/s1 KLFYGMCSUKVLQF-ISKFKSNPSA-N 382673 US10273259, Example 382::US10711020, Example 382 Nuclear receptor ROR-gamma [262-507] 38.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382673 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382673&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678740 404852027 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931295 CS(=O)(=O)N1CCC(CC(=O)N2CC[C@@]3([C@H]2CCc2cc(ccc32)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c2ccc(F)cc2)CC1 InChI=1S/C29H30F8N2O5S2/c1-45(41,42)38-13-10-18(11-14-38)16-25(40)39-15-12-26(46(43,44)22-6-4-21(30)5-7-22)23-8-3-20(17-19(23)2-9-24(26)39)27(31,28(32,33)34)29(35,36)37/h3-8,17-18,24H,2,9-16H2,1H3/t24-,26-/m1/s1 VIAPZQFNYCNANL-AOYPEHQESA-N 382674 US10273259, Example 383::US10711020, Example 383 Nuclear receptor ROR-gamma [262-507] 32.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382674 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382674&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679096 404852028 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931296 OC(=O)c1cc(ccc1O)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C29H21F8NO6S/c30-18-4-6-19(7-5-18)45(43,44)26-11-12-38(24(40)16-1-9-22(39)20(14-16)25(41)42)23(26)10-2-15-13-17(3-8-21(15)26)27(31,28(32,33)34)29(35,36)37/h1,3-9,13-14,23,39H,2,10-12H2,(H,41,42)/t23-,26-/m1/s1 SVMSLDKUKRXWKG-ZEQKJWHPSA-N 382675 US10273259, Example 384::US10711020, Example 384 Nuclear receptor ROR-gamma [262-507] 150 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382675 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382675&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678716 404852029 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931297 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)c1ccc(CC#N)cc1 InChI=1S/C30H22F8N2O3S/c31-22-7-9-23(10-8-22)44(42,43)27-14-16-40(26(41)19-3-1-18(2-4-19)13-15-39)25(27)12-5-20-17-21(6-11-24(20)27)28(32,29(33,34)35)30(36,37)38/h1-4,6-11,17,25H,5,12-14,16H2/t25-,27-/m1/s1 YOCMXJSMJZMBHH-XNMGPUDCSA-N 382676 US10273259, Example 385::US10711020, Example 385 Nuclear receptor ROR-gamma [262-507] 780 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382676 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382676&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678926 404852030 C04116 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931298 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)c1ccc(C#N)c(F)c1 InChI=1S/C29H19F9N2O3S/c30-20-5-7-21(8-6-20)44(42,43)26-11-12-40(25(41)17-1-2-18(15-39)23(31)14-17)24(26)10-3-16-13-19(4-9-22(16)26)27(32,28(33,34)35)29(36,37)38/h1-2,4-9,13-14,24H,3,10-12H2/t24-,26-/m1/s1 LYQHRMBDKHMXBU-AOYPEHQESA-N 382677 US10273259, Example 386::US10711020, Example 386 Nuclear receptor ROR-gamma [262-507] 215 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382677 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382677&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122669200 404852031 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931299 NC(=O)c1c(F)cc(cc1F)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C29H20F10N2O4S/c30-17-3-5-18(6-4-17)46(44,45)26-9-10-41(25(43)15-12-20(31)23(24(40)42)21(32)13-15)22(26)8-1-14-11-16(2-7-19(14)26)27(33,28(34,35)36)29(37,38)39/h2-7,11-13,22H,1,8-10H2,(H2,40,42)/t22-,26-/m1/s1 PSWQLEYTOSCYAF-ATIYNZHBSA-N 382678 US10273259, Example 387::US10711020, Example 387 Nuclear receptor ROR-gamma [262-507] 25.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382678 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382678&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678745 404852032 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931300 CC1CC(CCS1(=O)=O)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)c(C)c1 InChI=1S/C29H29F8NO5S2/c1-16-13-21(5-7-23(16)30)45(42,43)26-10-11-38(25(39)19-9-12-44(40,41)17(2)14-19)24(26)8-3-18-15-20(4-6-22(18)26)27(31,28(32,33)34)29(35,36)37/h4-7,13,15,17,19,24H,3,8-12,14H2,1-2H3 ZLUXNHCJQCSDDZ-UHFFFAOYSA-N 382679 US10273259, Example 388::US10273259, Example 389::US10711020, Example 389 Nuclear receptor ROR-gamma [262-507] 24.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382679 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382679&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679017 404852033 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931301 CC1CC(CCS1(=O)=O)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)c(C)c1 InChI=1S/C29H29F8NO5S2/c1-16-13-21(5-7-23(16)30)45(42,43)26-10-11-38(25(39)19-9-12-44(40,41)17(2)14-19)24(26)8-3-18-15-20(4-6-22(18)26)27(31,28(32,33)34)29(35,36)37/h4-7,13,15,17,19,24H,3,8-12,14H2,1-2H3 ZLUXNHCJQCSDDZ-UHFFFAOYSA-N 382679 US10273259, Example 388::US10273259, Example 389::US10711020, Example 389 Nuclear receptor ROR-gamma [262-507] 50.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382679 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382679&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679017 404852033 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931302 CC1CC(CCS1(=O)=O)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(Cl)cc1 InChI=1S/C28H27ClF7NO5S2/c1-16-14-18(10-13-43(16,39)40)24(38)37-12-11-25(44(41,42)21-6-4-20(29)5-7-21)22-8-3-19(15-17(22)2-9-23(25)37)26(30,27(31,32)33)28(34,35)36/h3-8,15-16,18,23H,2,9-14H2,1H3 UWKRQZVWZCDNKU-UHFFFAOYSA-N 382681 US10273259, Example 390::US10273259, Example 391::US10711020, Example 391 Nuclear receptor ROR-gamma [262-507] 27.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382681 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382681&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678635 404852034 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931303 CC1CC(CCS1(=O)=O)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(Cl)cc1 InChI=1S/C28H27ClF7NO5S2/c1-16-14-18(10-13-43(16,39)40)24(38)37-12-11-25(44(41,42)21-6-4-20(29)5-7-21)22-8-3-19(15-17(22)2-9-23(25)37)26(30,27(31,32)33)28(34,35)36/h3-8,15-16,18,23H,2,9-14H2,1H3 UWKRQZVWZCDNKU-UHFFFAOYSA-N 382681 US10273259, Example 390::US10273259, Example 391::US10711020, Example 391 Nuclear receptor ROR-gamma [262-507] 13.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382681 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382681&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678635 404852034 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931304 Cc1cc(ccc1F)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1CCS(=O)(=O)CC1 InChI=1S/C28H27F8NO5S2/c1-16-14-20(4-6-22(16)29)44(41,42)25-10-11-37(24(38)17-8-12-43(39,40)13-9-17)23(25)7-2-18-15-19(3-5-21(18)25)26(30,27(31,32)33)28(34,35)36/h3-6,14-15,17,23H,2,7-13H2,1H3 ZLKCPAJNBVGSGB-UHFFFAOYSA-N 382573 US10273259, Example 282::US10273259, Example 392::US10711020, Example 392 Nuclear receptor ROR-gamma [262-507] 56.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382573 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382573&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678618 404851931 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931305 Cc1cc(ccc1F)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)[C@H]1CC[C@@H](CC1)C(O)=O InChI=1S/C30H29F8NO5S/c1-16-14-21(8-10-23(16)31)45(43,44)27-12-13-39(25(40)17-2-4-18(5-3-17)26(41)42)24(27)11-6-19-15-20(7-9-22(19)27)28(32,29(33,34)35)30(36,37)38/h7-10,14-15,17-18,24H,2-6,11-13H2,1H3,(H,41,42)/t17-,18-,24?,27? HLPIMFURZPXHEZ-VRSFHCCXSA-N 382684 US10273259, Example 393::US10273259, Example 394::US10711020, Example 394 Nuclear receptor ROR-gamma [262-507] 4411 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382684 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382684&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678625 404852035 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931306 Cc1cc(ccc1F)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)[C@H]1CC[C@@H](CC1)C(O)=O InChI=1S/C30H29F8NO5S/c1-16-14-21(8-10-23(16)31)45(43,44)27-12-13-39(25(40)17-2-4-18(5-3-17)26(41)42)24(27)11-6-19-15-20(7-9-22(19)27)28(32,29(33,34)35)30(36,37)38/h7-10,14-15,17-18,24H,2-6,11-13H2,1H3,(H,41,42)/t17-,18-,24?,27? HLPIMFURZPXHEZ-VRSFHCCXSA-N 382684 US10273259, Example 393::US10273259, Example 394::US10711020, Example 394 Nuclear receptor ROR-gamma [262-507] 60.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382684 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382684&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678625 404852035 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931307 CC(C)c1cc(ccc1F)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)[C@H]1CC[C@@H](CC1)C(O)=O InChI=1S/C32H33F8NO5S/c1-17(2)23-16-22(9-11-25(23)33)47(45,46)29-13-14-41(27(42)18-3-5-19(6-4-18)28(43)44)26(29)12-7-20-15-21(8-10-24(20)29)30(34,31(35,36)37)32(38,39)40/h8-11,15-19,26H,3-7,12-14H2,1-2H3,(H,43,44)/t18-,19-,26?,29? UVYWQJZRZXZHKO-HOBQQJKGSA-N 382686 US10273259, Example 395::US10711020, Example 395 Nuclear receptor ROR-gamma [262-507] 58.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382686 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382686&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678735 404852036 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931308 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1CCS(=O)(=O)C1 InChI=1S/C26H23F8NO5S2/c27-18-3-5-19(6-4-18)42(39,40)23-10-11-35(22(36)16-9-12-41(37,38)14-16)21(23)8-1-15-13-17(2-7-20(15)23)24(28,25(29,30)31)26(32,33)34/h2-7,13,16,21H,1,8-12,14H2/t16?,21-,23-/m1/s1 MQPDYHGYOCEGLJ-KDTADFBSSA-N 382688 US10273259, Example 397::US10273259, Example 400::US10711020, Example 400 Nuclear receptor ROR-gamma [262-507] 29.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382688 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382688&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678645 404852038 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931309 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1CCS(=O)(=O)C1 InChI=1S/C26H23F8NO5S2/c27-18-3-5-19(6-4-18)42(39,40)23-10-11-35(22(36)16-9-12-41(37,38)14-16)21(23)8-1-15-13-17(2-7-20(15)23)24(28,25(29,30)31)26(32,33)34/h2-7,13,16,21H,1,8-12,14H2/t16?,21-,23-/m1/s1 MQPDYHGYOCEGLJ-KDTADFBSSA-N 382688 US10273259, Example 397::US10273259, Example 400::US10711020, Example 400 Nuclear receptor ROR-gamma [262-507] 90.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382688 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382688&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678645 404852038 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931310 OC(=O)[C@@]1(O)CC[C@@H](CC1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C29H27F8NO6S/c30-19-3-5-20(6-4-19)45(43,44)26-13-14-38(23(39)16-9-11-25(42,12-10-16)24(40)41)22(26)8-1-17-15-18(2-7-21(17)26)27(31,28(32,33)34)29(35,36)37/h2-7,15-16,22,42H,1,8-14H2,(H,40,41)/t16-,22-,25+,26-/m1/s1 UAAXXHYNFYTCMH-PNOGGZOTSA-N 382689 US10273259, Example 398::US10711020, Example 398 Nuclear receptor ROR-gamma [262-507] 40.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382689 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382689&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678699 404852039 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931311 CC(C)c1cc(ccc1F)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)[C@@]1(F)CC[C@@H](CC1)C(O)=O InChI=1S/C32H32F9NO5S/c1-17(2)22-16-21(5-7-24(22)33)48(46,47)29-13-14-42(27(45)28(34)11-9-18(10-12-28)26(43)44)25(29)8-3-19-15-20(4-6-23(19)29)30(35,31(36,37)38)32(39,40)41/h4-7,15-18,25H,3,8-14H2,1-2H3,(H,43,44)/t18-,25?,28+,29? CAFPAOPORLESDV-BYAWYYDZSA-N 382690 US10273259, Example 399::US10711020, Example 399 Nuclear receptor ROR-gamma [262-507] 48.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382690 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382690&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679143 404852040 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931312 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1CCS(=O)(=O)C1 InChI=1S/C26H23F8NO5S2/c27-18-3-5-19(6-4-18)42(39,40)23-10-11-35(22(36)16-9-12-41(37,38)14-16)21(23)8-1-15-13-17(2-7-20(15)23)24(28,25(29,30)31)26(32,33)34/h2-7,13,16,21H,1,8-12,14H2/t16?,21-,23-/m1/s1 MQPDYHGYOCEGLJ-KDTADFBSSA-N 382688 US10273259, Example 397::US10273259, Example 400::US10711020, Example 400 Nuclear receptor ROR-gamma [262-507] 87.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382688 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382688&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678645 404852038 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931313 CC(C)c1cc(ccc1F)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1(O)CCS(=O)(=O)CC1 InChI=1S/C30H31F8NO6S2/c1-17(2)21-16-20(5-7-23(21)31)47(44,45)27-9-12-39(25(40)26(41)10-13-46(42,43)14-11-26)24(27)8-3-18-15-19(4-6-22(18)27)28(32,29(33,34)35)30(36,37)38/h4-7,15-17,24,41H,3,8-14H2,1-2H3 MBBCCEFPCBIYCJ-UHFFFAOYSA-N 382692 US10273259, Example 401::US10711020, Example 401 Nuclear receptor ROR-gamma [262-507] 134 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382692 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382692&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678644 404852041 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931314 CC(C)c1cc(ccc1F)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C12CCC(CC1)(CC2)C(O)=O InChI=1S/C34H35F8NO5S/c1-19(2)23-18-22(5-7-25(23)35)49(47,48)31-15-16-43(27(44)29-9-12-30(13-10-29,14-11-29)28(45)46)26(31)8-3-20-17-21(4-6-24(20)31)32(36,33(37,38)39)34(40,41)42/h4-7,17-19,26H,3,8-16H2,1-2H3,(H,45,46) JSYKHBPCHDJROF-UHFFFAOYSA-N 382693 US10273259, Example 402::US10711020, Example 402 Nuclear receptor ROR-gamma [262-507] 638 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382693 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382693&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678517 404852042 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931315 OC(=O)[C@H]1CC[C@@](F)(CC1)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(Cl)c(Cl)c1 InChI=1S/C29H25Cl2F8NO5S/c30-20-5-3-18(14-21(20)31)46(44,45)26-11-12-40(24(43)25(32)9-7-15(8-10-25)23(41)42)22(26)6-1-16-13-17(2-4-19(16)26)27(33,28(34,35)36)29(37,38)39/h2-5,13-15,22H,1,6-12H2,(H,41,42)/t15-,22?,25+,26? CSTNVACFPMQTLI-CQQLRPNFSA-N 382694 US10273259, Example 403::US10711020, Example 403 Nuclear receptor ROR-gamma [262-507] 46.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382694 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382694&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678934 404852043 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931316 OC1(CCS(=O)(=O)CC1)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(Cl)c(Cl)c1 InChI=1S/C27H24Cl2F7NO6S2/c28-19-5-3-17(14-20(19)29)45(42,43)24-7-10-37(22(38)23(39)8-11-44(40,41)12-9-23)21(24)6-1-15-13-16(2-4-18(15)24)25(30,26(31,32)33)27(34,35)36/h2-5,13-14,21,39H,1,6-12H2 XWNSASURLTZSBY-UHFFFAOYSA-N 382695 US10273259, Example 404::US10711020, Example 404 Nuclear receptor ROR-gamma [262-507] 34.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382695 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382695&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678629 404852044 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931317 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(Cl)c(Cl)c1 InChI=1S/C29H26Cl2F7NO5S/c30-21-9-7-19(14-22(21)31)45(43,44)26-11-12-39(24(40)15-1-3-16(4-2-15)25(41)42)23(26)10-5-17-13-18(6-8-20(17)26)27(32,28(33,34)35)29(36,37)38/h6-9,13-16,23H,1-5,10-12H2,(H,41,42)/t15-,16-,23?,26? SRLZSKMQJBCAIV-KMLPXHMCSA-N 382696 US10273259, Example 405::US10711020, Example 405 Nuclear receptor ROR-gamma [262-507] 12.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382696 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382696&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679030 404852045 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931318 Cc1cc(ccc1F)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C12CCC(CC1)(CC2)C(O)=O InChI=1S/C32H31F8NO5S/c1-18-16-21(4-6-23(18)33)47(45,46)29-14-15-41(25(42)27-8-11-28(12-9-27,13-10-27)26(43)44)24(29)7-2-19-17-20(3-5-22(19)29)30(34,31(35,36)37)32(38,39)40/h3-6,16-17,24H,2,7-15H2,1H3,(H,43,44) SHMZBEASAIVZGQ-UHFFFAOYSA-N 382570 US10273259, Example 279::US10273259, Example 406::US10711020, Example 406 Nuclear receptor ROR-gamma [262-507] 31.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382570 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382570&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679057 404851928 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931319 Cc1cc(ccc1F)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)[C@@]1(F)CC[C@@H](CC1)C(O)=O InChI=1S/C30H28F9NO5S/c1-16-14-20(4-6-22(16)31)46(44,45)27-12-13-40(25(43)26(32)10-8-17(9-11-26)24(41)42)23(27)7-2-18-15-19(3-5-21(18)27)28(33,29(34,35)36)30(37,38)39/h3-6,14-15,17,23H,2,7-13H2,1H3,(H,41,42)/t17-,23?,26+,27? HMUIKTMNWCIRAR-MTOUGUCQSA-N 382571 US10273259, Example 280::US10711020, Example 407 Nuclear receptor ROR-gamma [262-507] 21.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382571 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382571&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678841 404851929 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931320 OC(=O)C1CCC(C1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H25F8NO5S/c29-19-5-7-20(8-6-19)43(41,42)25-11-12-37(23(38)16-1-2-17(13-16)24(39)40)22(25)10-3-15-14-18(4-9-21(15)25)26(30,27(31,32)33)28(34,35)36/h4-9,14,16-17,22H,1-3,10-13H2,(H,39,40)/t16?,17?,22-,25-/m1/s1 XRRXYBCURUVMRW-AZNPCEPYSA-N 382699 US10273259, Example 408::US10273259, Example 525::US10273259, Example 526::US10273259, Example 527::US10273259, Example 528::US10711020, Example 528 Nuclear receptor ROR-gamma [262-507] 73.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382699 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382699&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678527 404852047 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931321 OC(=O)C1CCC(CC(=O)N2CC[C@@]3([C@H]2CCc2cc(ccc32)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c2ccc(F)cc2)C1 InChI=1S/C29H27F8NO5S/c30-20-5-7-21(8-6-20)44(42,43)26-11-12-38(24(39)14-16-1-2-18(13-16)25(40)41)23(26)10-3-17-15-19(4-9-22(17)26)27(31,28(32,33)34)29(35,36)37/h4-9,15-16,18,23H,1-3,10-14H2,(H,40,41)/t16?,18?,23-,26-/m1/s1 CLLSKFXPLSGITG-LJMAUKNNSA-N 453446 US10711020, Example 409 Nuclear receptor ROR-gamma [262-507] 143 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=453446 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=453446&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679015 440969349 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931322 CS(=O)(=O)N1CCC(F)(CC1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H27F9N2O5S2/c1-45(41,42)38-13-10-24(30,11-14-38)23(40)39-15-12-25(46(43,44)20-6-4-19(29)5-7-20)21-8-3-18(16-17(21)2-9-22(25)39)26(31,27(32,33)34)28(35,36)37/h3-8,16,22H,2,9-15H2,1H3/t22-,25-/m1/s1 AXYMWEHYHGFQIE-RCZVLFRGSA-N 382701 US10273259, Example 410::US10711020, Example 410 Nuclear receptor ROR-gamma [262-507] 47.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382701 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382701&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678620 404852049 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931323 OC(=O)C12CC(C1)(C2)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H23F8NO5S/c29-17-3-5-18(6-4-17)43(41,42)25-9-10-37(21(38)23-12-24(13-23,14-23)22(39)40)20(25)8-1-15-11-16(2-7-19(15)25)26(30,27(31,32)33)28(34,35)36/h2-7,11,20H,1,8-10,12-14H2,(H,39,40)/t20-,23?,24?,25-/m1/s1 VCOSISKXMJHFPP-ZSAXZHEQSA-N 382702 US10273259, Example 411::US10711020, Example 411 Nuclear receptor ROR-gamma [262-507] 16.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382702 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382702&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679031 404852050 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931324 CS(=O)(=O)NC1CC2(C1)CC(C2)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C30H30F8N2O5S2/c1-46(42,43)39-21-15-26(16-21)13-18(14-26)25(41)40-11-10-27(47(44,45)22-6-4-20(31)5-7-22)23-8-3-19(12-17(23)2-9-24(27)40)28(32,29(33,34)35)30(36,37)38/h3-8,12,18,21,24,39H,2,9-11,13-16H2,1H3/t18?,21?,24-,26?,27-/m1/s1 GPCHRRGMXNZQNW-VUKGGDMXSA-N 453449 US10711020, Example 412 Nuclear receptor ROR-gamma [262-507] 34.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=453449 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=453449&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679142 440969352 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931325 OCC1(CCNCC1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H28F8N2O4S/c29-19-3-5-20(6-4-19)43(41,42)25-11-14-38(23(40)24(16-39)9-12-37-13-10-24)22(25)8-1-17-15-18(2-7-21(17)25)26(30,27(31,32)33)28(34,35)36/h2-7,15,22,37,39H,1,8-14,16H2/t22-,25-/m1/s1 BMLHBAGBPLSTOG-RCZVLFRGSA-N 382704 US10273259, Example 413::US10711020, Example 413 Nuclear receptor ROR-gamma [262-507] 15.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382704 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382704&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678835 404852052 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931326 CS(=O)(=O)N1CCC(CO)(CC1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C29H30F8N2O6S2/c1-46(42,43)38-13-10-25(17-40,11-14-38)24(41)39-15-12-26(47(44,45)21-6-4-20(30)5-7-21)22-8-3-19(16-18(22)2-9-23(26)39)27(31,28(32,33)34)29(35,36)37/h3-8,16,23,40H,2,9-15,17H2,1H3/t23-,26-/m1/s1 VOIHBOVYCLWYMD-ZEQKJWHPSA-N 382705 US10273259, Example 414::US10711020, Example 414 Nuclear receptor ROR-gamma [262-507] 20.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382705 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382705&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678942 404852053 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931327 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1CCOCC1 InChI=1S/C27H25F8NO4S/c28-19-3-5-20(6-4-19)41(38,39)24-11-12-36(23(37)16-9-13-40-14-10-16)22(24)8-1-17-15-18(2-7-21(17)24)25(29,26(30,31)32)27(33,34)35/h2-7,15-16,22H,1,8-14H2/t22-,24-/m1/s1 RRUIDSFYZVLBPV-ISKFKSNPSA-N 382706 US10273259, Example 415::US10711020, Example 415 Nuclear receptor ROR-gamma [262-507] 14.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382706 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382706&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678522 404852054 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931328 NC(=O)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C23H18F8N2O4S/c24-14-3-5-15(6-4-14)38(36,37)20-9-10-33(19(35)18(32)34)17(20)8-1-12-11-13(2-7-16(12)20)21(25,22(26,27)28)23(29,30)31/h2-7,11,17H,1,8-10H2,(H2,32,34)/t17-,20-/m1/s1 RFPHYYFHTLPVST-YLJYHZDGSA-N 382707 US10273259, Example 416::US10711020, Example 416 Nuclear receptor ROR-gamma [262-507] 135 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382707 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382707&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678660 404852055 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931329 CNC(=O)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C24H20F8N2O4S/c1-33-19(35)20(36)34-11-10-21(39(37,38)16-6-4-15(25)5-7-16)17-8-3-14(12-13(17)2-9-18(21)34)22(26,23(27,28)29)24(30,31)32/h3-8,12,18H,2,9-11H2,1H3,(H,33,35)/t18-,21-/m1/s1 QPIOFEWTPWOHDQ-WIYYLYMNSA-N 382708 US10273259, Example 417::US10711020, Example 417 Nuclear receptor ROR-gamma [262-507] 178 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382708 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382708&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679138 404852056 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931330 NC(=O)CC(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C24H20F8N2O4S/c25-15-3-5-16(6-4-15)39(37,38)21-9-10-34(20(36)12-19(33)35)18(21)8-1-13-11-14(2-7-17(13)21)22(26,23(27,28)29)24(30,31)32/h2-7,11,18H,1,8-10,12H2,(H2,33,35)/t18-,21-/m1/s1 QWYSBNUYXPHNOA-WIYYLYMNSA-N 382709 US10273259, Example 418::US10711020, Example 418 Nuclear receptor ROR-gamma [262-507] 128 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382709 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382709&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679147 404852057 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931331 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)c1ncc[nH]1 382710 US10273259, Example 419::US10711020, Example 419 Nuclear receptor ROR-gamma [262-507] 1106 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382710 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382710&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679047 404852058 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931332 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)c1nnn[nH]1 382711 US10273259, Example 420::US10711020, Example 420 Nuclear receptor ROR-gamma [262-507] 732 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382711 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382711&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678526 404852059 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931333 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)Cc1nnn[nH]1 382712 US10273259, Example 421::US10711020, Example 421 Nuclear receptor ROR-gamma [262-507] 164 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382712 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382712&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679126 404852060 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931334 CCS(=O)(=O)c1ccc(CC(=O)N2CC[C@@]3([C@H]2CCc2cc(ccc32)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c2ccc(F)cc2)cc1 InChI=1S/C31H27F8NO5S2/c1-2-46(42,43)23-9-3-19(4-10-23)17-27(41)40-16-15-28(47(44,45)24-11-7-22(32)8-12-24)25-13-6-21(18-20(25)5-14-26(28)40)29(33,30(34,35)36)31(37,38)39/h3-4,6-13,18,26H,2,5,14-17H2,1H3/t26-,28-/m1/s1 FSYKKORHAQSADK-IXCJQBJRSA-N 382713 US10273259, Example 422::US10711020, Example 422 Nuclear receptor ROR-gamma [262-507] 87.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382713 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382713&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678912 404852061 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931335 CC(C)(C)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C26H25F8NO3S/c1-22(2,3)21(36)35-13-12-23(39(37,38)18-8-6-17(27)7-9-18)19-10-5-16(14-15(19)4-11-20(23)35)24(28,25(29,30)31)26(32,33)34/h5-10,14,20H,4,11-13H2,1-3H3/t20-,23-/m1/s1 ZDGCIDCRAGIXSY-NFBKMPQASA-N 382714 US10273259, Example 423::US10711020, Example 423 Nuclear receptor ROR-gamma [262-507] 46.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382714 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382714&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679150 404852062 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931336 CC(C)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C25H23F8NO3S/c1-14(2)21(35)34-12-11-22(38(36,37)18-7-5-17(26)6-8-18)19-9-4-16(13-15(19)3-10-20(22)34)23(27,24(28,29)30)25(31,32)33/h4-9,13-14,20H,3,10-12H2,1-2H3/t20-,22-/m1/s1 PZEOTOMZRDNWHA-IFMALSPDSA-N 382715 US10273259, Example 424::US10711020, Example 424 Nuclear receptor ROR-gamma [262-507] 84.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382715 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382715&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678948 404852063 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931337 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1(CCC1)C(F)(F)F InChI=1S/C27H22F11NO3S/c28-17-4-6-18(7-5-17)43(41,42)23-12-13-39(21(40)22(10-1-11-22)25(30,31)32)20(23)9-2-15-14-16(3-8-19(15)23)24(29,26(33,34)35)27(36,37)38/h3-8,14,20H,1-2,9-13H2/t20-,23-/m1/s1 UCNQYSBFRVQZAI-NFBKMPQASA-N 382716 US10273259, Example 425::US10711020, Example 425 Nuclear receptor ROR-gamma [262-507] 55.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382716 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382716&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678969 404852064 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931338 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C#C InChI=1S/C24H17F8NO3S/c1-2-20(34)33-12-11-21(37(35,36)17-7-5-16(25)6-8-17)18-9-4-15(13-14(18)3-10-19(21)33)22(26,23(27,28)29)24(30,31)32/h1,4-9,13,19H,3,10-12H2/t19-,21-/m1/s1 VTXNXWQKVCWVFI-TZIWHRDSSA-N 382717 US10273259, Example 426::US10711020, Example 426 Nuclear receptor ROR-gamma [262-507] 956 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382717 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382717&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678520 404852065 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931339 CC#CC(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C25H19F8NO3S/c1-2-3-21(35)34-13-12-22(38(36,37)18-8-6-17(26)7-9-18)19-10-5-16(14-15(19)4-11-20(22)34)23(27,24(28,29)30)25(31,32)33/h5-10,14,20H,4,11-13H2,1H3/t20-,22-/m1/s1 ZMJVPQUCVMDEPO-IFMALSPDSA-N 382718 US10273259, Example 427::US10711020, Example 427 Nuclear receptor ROR-gamma [262-507] 272 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382718 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382718&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678956 404852066 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931340 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1CC1 InChI=1S/C25H21F8NO3S/c26-17-5-7-18(8-6-17)38(36,37)22-11-12-34(21(35)14-1-2-14)20(22)10-3-15-13-16(4-9-19(15)22)23(27,24(28,29)30)25(31,32)33/h4-9,13-14,20H,1-3,10-12H2/t20-,22-/m1/s1 DGVMLHUCFQGWJB-IFMALSPDSA-N 382719 US10273259, Example 428::US10711020, Example 428 Nuclear receptor ROR-gamma [262-507] 50.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382719 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382719&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679152 404852067 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931341 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1CC(F)(F)C1 InChI=1S/C26H21F10NO3S/c27-17-3-5-18(6-4-17)41(39,40)23-9-10-37(21(38)15-12-22(28,29)13-15)20(23)8-1-14-11-16(2-7-19(14)23)24(30,25(31,32)33)26(34,35)36/h2-7,11,15,20H,1,8-10,12-13H2/t20-,23-/m1/s1 QSDJZAIYWPFVKD-NFBKMPQASA-N 382720 US10273259, Example 429::US10711020, Example 429 Nuclear receptor ROR-gamma [262-507] 173 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382720 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382720&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679122 404852068 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931342 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1(CCC1)C#N InChI=1S/C27H22F8N2O3S/c28-18-4-6-19(7-5-18)41(39,40)24-12-13-37(22(38)23(15-36)10-1-11-23)21(24)9-2-16-14-17(3-8-20(16)24)25(29,26(30,31)32)27(33,34)35/h3-8,14,21H,1-2,9-13H2/t21-,24-/m1/s1 CKFFJKYUQOUQAR-ZJSXRUAMSA-N 382721 US10273259, Example 430::US10711020, Example 430 Nuclear receptor ROR-gamma [262-507] 77.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382721 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382721&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679036 404852069 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931343 CC1(C)C(C(=O)N2CC[C@@]3([C@H]2CCc2cc(ccc32)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c2ccc(F)cc2)C1(C)C InChI=1S/C29H29F8NO3S/c1-24(2)22(25(24,3)4)23(39)38-14-13-26(42(40,41)19-9-7-18(30)8-10-19)20-11-6-17(15-16(20)5-12-21(26)38)27(31,28(32,33)34)29(35,36)37/h6-11,15,21-22H,5,12-14H2,1-4H3/t21-,26-/m1/s1 UOCIENQBFQTBKD-QFQXNSOFSA-N 382722 US10273259, Example 431::US10711020, Example 431 Nuclear receptor ROR-gamma [262-507] 44.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382722 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382722&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679103 404852070 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931344 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)[C@H]1[C@H]2COC[C@@H]12 InChI=1S/C27H23F8NO4S/c28-16-3-5-17(6-4-16)41(38,39)24-9-10-36(23(37)22-18-12-40-13-19(18)22)21(24)8-1-14-11-15(2-7-20(14)24)25(29,26(30,31)32)27(33,34)35/h2-7,11,18-19,21-22H,1,8-10,12-13H2/t18-,19+,21-,22-,24-/m1/s1 MCVPKUDMFTZCOJ-MMUOCADFSA-N 382723 US10273259, Example 432::US10711020, Example 432 Nuclear receptor ROR-gamma [262-507] 52.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382723 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382723&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679037 404852071 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931345 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1CCC1 InChI=1S/C26H23F8NO3S/c27-18-6-8-19(9-7-18)39(37,38)23-12-13-35(22(36)15-2-1-3-15)21(23)11-4-16-14-17(5-10-20(16)23)24(28,25(29,30)31)26(32,33)34/h5-10,14-15,21H,1-4,11-13H2/t21-,23-/m1/s1 MZVOIROIUZWGJI-FYYLOGMGSA-N 382724 US10273259, Example 433::US10711020, Example 433 Nuclear receptor ROR-gamma [262-507] 63.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382724 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382724&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679168 404852072 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931346 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)CC(F)(F)F InChI=1S/C24H18F11NO3S/c25-15-3-5-16(6-4-15)40(38,39)20-9-10-36(19(37)12-21(26,27)28)18(20)8-1-13-11-14(2-7-17(13)20)22(29,23(30,31)32)24(33,34)35/h2-7,11,18H,1,8-10,12H2/t18-,20-/m1/s1 BQRALVPHWJHCKT-UYAOXDASSA-N 382725 US10273259, Example 434::US10711020, Example 434 Nuclear receptor ROR-gamma [262-507] 86.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382725 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382725&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678651 404852073 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931347 CC1(CC1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C26H23F8NO3S/c1-22(10-11-22)21(36)35-13-12-23(39(37,38)18-6-4-17(27)5-7-18)19-8-3-16(14-15(19)2-9-20(23)35)24(28,25(29,30)31)26(32,33)34/h3-8,14,20H,2,9-13H2,1H3/t20-,23-/m1/s1 KSVOVRFPDQTPFV-NFBKMPQASA-N 382726 US10273259, Example 435::US10711020, Example 435 Nuclear receptor ROR-gamma [262-507] 188 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382726 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382726&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679131 404852074 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931348 FC1CC(C1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C26H22F9NO3S/c27-17-3-5-19(6-4-17)40(38,39)23-9-10-36(22(37)15-12-18(28)13-15)21(23)8-1-14-11-16(2-7-20(14)23)24(29,25(30,31)32)26(33,34)35/h2-7,11,15,18,21H,1,8-10,12-13H2/t15?,18?,21-,23-/m1/s1 IHVZWPJUIUZODC-XGZPXUMOSA-N 382727 US10273259, Example 436::US10273259, Example 437::US10711020, Example 437 Nuclear receptor ROR-gamma [262-507] 49.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382727 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382727&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678655 404852075 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931349 FC1CC(C1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C26H22F9NO3S/c27-17-3-5-19(6-4-17)40(38,39)23-9-10-36(22(37)15-12-18(28)13-15)21(23)8-1-14-11-16(2-7-20(14)23)24(29,25(30,31)32)26(33,34)35/h2-7,11,15,18,21H,1,8-10,12-13H2/t15?,18?,21-,23-/m1/s1 IHVZWPJUIUZODC-XGZPXUMOSA-N 382727 US10273259, Example 436::US10273259, Example 437::US10711020, Example 437 Nuclear receptor ROR-gamma [262-507] 51.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382727 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382727&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678655 404852075 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931350 CC(O)(C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1)C(F)(F)F InChI=1S/C25H20F11NO4S/c1-20(39,23(28,29)30)19(38)37-11-10-21(42(40,41)16-6-4-15(26)5-7-16)17-8-3-14(12-13(17)2-9-18(21)37)22(27,24(31,32)33)25(34,35)36/h3-8,12,18,39H,2,9-11H2,1H3/t18-,20?,21-/m1/s1 NKKSYHKSTOWHIH-TXZDUHFLSA-N 382729 US10273259, Example 438::US10711020, Example 438 Nuclear receptor ROR-gamma [262-507] 73.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382729 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382729&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679144 404852076 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931351 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1(CC1)C(F)(F)F InChI=1S/C26H20F11NO3S/c27-16-3-5-17(6-4-16)42(40,41)22-11-12-38(20(39)21(9-10-21)24(29,30)31)19(22)8-1-14-13-15(2-7-18(14)22)23(28,25(32,33)34)26(35,36)37/h2-7,13,19H,1,8-12H2/t19-,22-/m1/s1 GCMFUUXMYRLJTH-DENIHFKCSA-N 382730 US10273259, Example 439::US10711020, Example 439 Nuclear receptor ROR-gamma [262-507] 214 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382730 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382730&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679160 404852077 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931352 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1COC1 InChI=1S/C25H21F8NO4S/c26-17-3-5-18(6-4-17)39(36,37)22-9-10-34(21(35)15-12-38-13-15)20(22)8-1-14-11-16(2-7-19(14)22)23(27,24(28,29)30)25(31,32)33/h2-7,11,15,20H,1,8-10,12-13H2/t20-,22-/m1/s1 CSJOJZVZBOTLNM-IFMALSPDSA-N 382731 US10273259, Example 440::US10711020, Example 440 Nuclear receptor ROR-gamma [262-507] 72.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382731 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382731&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678960 404852078 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931353 OC(=O)C1(CCC1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C27H23F8NO5S/c28-17-4-6-18(7-5-17)42(40,41)24-12-13-36(21(37)23(22(38)39)10-1-11-23)20(24)9-2-15-14-16(3-8-19(15)24)25(29,26(30,31)32)27(33,34)35/h3-8,14,20H,1-2,9-13H2,(H,38,39)/t20-,24-/m1/s1 MGEITVYVWKMTKQ-HYBUGGRVSA-N 382732 US10273259, Example 441::US10711020, Example 441 Nuclear receptor ROR-gamma [262-507] 159 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382732 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382732&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679167 404852079 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931354 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1(CCCC1)C(F)(F)F InChI=1S/C28H24F11NO3S/c29-18-5-7-19(8-6-18)44(42,43)24-13-14-40(22(41)23(26(31,32)33)11-1-2-12-23)21(24)10-3-16-15-17(4-9-20(16)24)25(30,27(34,35)36)28(37,38)39/h4-9,15,21H,1-3,10-14H2/t21-,24-/m1/s1 VMKQXKDIUXZZDG-ZJSXRUAMSA-N 382733 US10273259, Example 442::US10711020, Example 442 Nuclear receptor ROR-gamma [262-507] 145 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382733 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382733&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678662 404852080 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931355 CC(C)(C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1)C(F)(F)F InChI=1S/C26H22F11NO3S/c1-21(2,24(29,30)31)20(39)38-12-11-22(42(40,41)17-7-5-16(27)6-8-17)18-9-4-15(13-14(18)3-10-19(22)38)23(28,25(32,33)34)26(35,36)37/h4-9,13,19H,3,10-12H2,1-2H3/t19-,22-/m1/s1 NPEVFGJGEHYCQW-DENIHFKCSA-N 382734 US10273259, Example 443::US10273259, Example 475::US10711020, Example 476 Nuclear receptor ROR-gamma [262-507] 48.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382734 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382734&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678665 404852081 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931356 CC(C)(O)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C25H23F8NO4S/c1-21(2,36)20(35)34-12-11-22(39(37,38)17-7-5-16(26)6-8-17)18-9-4-15(13-14(18)3-10-19(22)34)23(27,24(28,29)30)25(31,32)33/h4-9,13,19,36H,3,10-12H2,1-2H3/t19-,22-/m1/s1 ISLBBCMLQNJKEJ-DENIHFKCSA-N 382735 US10273259, Example 444::US10711020, Example 444 Nuclear receptor ROR-gamma [262-507] 45.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382735 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382735&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678675 404852082 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931357 OCC(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C23H19F8NO4S/c24-15-3-5-16(6-4-15)37(35,36)20-9-10-32(19(34)12-33)18(20)8-1-13-11-14(2-7-17(13)20)21(25,22(26,27)28)23(29,30)31/h2-7,11,18,33H,1,8-10,12H2/t18-,20-/m1/s1 CKKJHGTWWADHAE-UYAOXDASSA-N 382736 US10273259, Example 445::US10711020, Example 445 Nuclear receptor ROR-gamma [262-507] 70.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382736 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382736&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678754 404852083 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931358 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1CCC(F)(F)CC1 InChI=1S/C28H25F10NO3S/c29-19-3-5-20(6-4-19)43(41,42)25-13-14-39(23(40)16-9-11-24(30,31)12-10-16)22(25)8-1-17-15-18(2-7-21(17)25)26(32,27(33,34)35)28(36,37)38/h2-7,15-16,22H,1,8-14H2/t22-,25-/m1/s1 AOPFHWGNRUOVBK-RCZVLFRGSA-N 382737 US10273259, Example 446::US10711020, Example 446 Nuclear receptor ROR-gamma [262-507] 143 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382737 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382737&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678659 404852084 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931359 O[C@@H](C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1)C(F)(F)F InChI=1S/C24H18F11NO4S/c25-14-3-5-15(6-4-14)41(39,40)20-9-10-36(19(38)18(37)22(27,28)29)17(20)8-1-12-11-13(2-7-16(12)20)21(26,23(30,31)32)24(33,34)35/h2-7,11,17-18,37H,1,8-10H2/t17-,18+,20-/m1/s1 XDCCRDKBCXJGQP-WSTZPKSXSA-N 382738 US10273259, Example 447::US10711020, Example 447 Nuclear receptor ROR-gamma [262-507] 14.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382738 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382738&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679156 404852085 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931360 CS(=O)(=O)CC(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C24H21F8NO5S2/c1-39(35,36)13-20(34)33-11-10-21(40(37,38)17-6-4-16(25)5-7-17)18-8-3-15(12-14(18)2-9-19(21)33)22(26,23(27,28)29)24(30,31)32/h3-8,12,19H,2,9-11,13H2,1H3/t19-,21-/m1/s1 LASKNXVSIDQPHY-TZIWHRDSSA-N 382739 US10273259, Example 448::US10711020, Example 448 Nuclear receptor ROR-gamma [262-507] 26.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382739 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382739&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679162 404852086 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931361 CC(C)S(=O)(=O)CC(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C26H25F8NO5S2/c1-15(2)41(37,38)14-22(36)35-12-11-23(42(39,40)19-7-5-18(27)6-8-19)20-9-4-17(13-16(20)3-10-21(23)35)24(28,25(29,30)31)26(32,33)34/h4-9,13,15,21H,3,10-12,14H2,1-2H3/t21-,23-/m1/s1 XBPPGWNYVTWTKT-FYYLOGMGSA-N 382740 US10273259, Example 449::US10711020, Example 449 Nuclear receptor ROR-gamma [262-507] 30.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382740 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382740&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678658 404852087 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931362 CC(C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1)S(C)(=O)=O InChI=1S/C25H23F8NO5S2/c1-14(40(2,36)37)21(35)34-12-11-22(41(38,39)18-7-5-17(26)6-8-18)19-9-4-16(13-15(19)3-10-20(22)34)23(27,24(28,29)30)25(31,32)33/h4-9,13-14,20H,3,10-12H2,1-2H3/t14?,20-,22-/m1/s1 UHPWILVTCPQMJG-FRPDIZBGSA-N 382741 US10273259, Example 450::US10711020, Example 450 Nuclear receptor ROR-gamma [262-507] 32.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382741 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382741&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679171 404852088 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931363 Fc1ccc(cc1)S(=O)(=O)CC(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C29H22F9NO5S2/c30-19-3-7-21(8-4-19)45(41,42)16-25(40)39-14-13-26(46(43,44)22-9-5-20(31)6-10-22)23-11-2-18(15-17(23)1-12-24(26)39)27(32,28(33,34)35)29(36,37)38/h2-11,15,24H,1,12-14,16H2/t24-,26-/m1/s1 IUCRZXFSMDUWGK-AOYPEHQESA-N 382742 US10273259, Example 451::US10711020, Example 451 Nuclear receptor ROR-gamma [262-507] 177 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382742 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382742&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678963 404852089 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931364 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)CS(=O)(=O)c1ccccc1 InChI=1S/C29H23F8NO5S2/c30-20-8-10-22(11-9-20)45(42,43)26-14-15-38(25(39)17-44(40,41)21-4-2-1-3-5-21)24(26)13-6-18-16-19(7-12-23(18)26)27(31,28(32,33)34)29(35,36)37/h1-5,7-12,16,24H,6,13-15,17H2/t24-,26-/m1/s1 QWXOCEUSGWHMSH-AOYPEHQESA-N 382743 US10273259, Example 452::US10711020, Example 452 Nuclear receptor ROR-gamma [262-507] 153 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382743 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382743&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679064 404852090 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931365 CC(CS(=O)(=O)c1ccc(Cl)cc1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C31H26ClF8NO5S2/c1-18(17-47(43,44)23-8-4-21(32)5-9-23)27(42)41-15-14-28(48(45,46)24-10-6-22(33)7-11-24)25-12-3-20(16-19(25)2-13-26(28)41)29(34,30(35,36)37)31(38,39)40/h3-12,16,18,26H,2,13-15,17H2,1H3/t18?,26-,28-/m1/s1 HJYAVGSDGOESHW-QAFNWWFMSA-N 382744 US10273259, Example 453::US10711020, Example 453 Nuclear receptor ROR-gamma [262-507] 443 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382744 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382744&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678889 404852091 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931366 CC(C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1)S(=O)(=O)c1ccc(cn1)C(F)(F)F InChI=1S/C30H23F11N2O5S2/c1-16(49(45,46)24-11-4-19(15-42-24)28(33,34)35)25(44)43-13-12-26(50(47,48)21-7-5-20(31)6-8-21)22-9-3-18(14-17(22)2-10-23(26)43)27(32,29(36,37)38)30(39,40)41/h3-9,11,14-16,23H,2,10,12-13H2,1H3/t16?,23-,26-/m1/s1 LJGSUUCDIWSYNO-OAJVEDRUSA-N 382745 US10273259, Example 454::US10711020, Example 454 Nuclear receptor ROR-gamma [262-507] 718 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382745 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382745&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679002 404852092 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931367 CC(CC(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1)S(=O)(=O)c1ccc(Cl)cc1 InChI=1S/C31H26ClF8NO5S2/c1-18(47(43,44)23-8-4-21(32)5-9-23)16-27(42)41-15-14-28(48(45,46)24-10-6-22(33)7-11-24)25-12-3-20(17-19(25)2-13-26(28)41)29(34,30(35,36)37)31(38,39)40/h3-12,17-18,26H,2,13-16H2,1H3/t18?,26-,28-/m1/s1 XARPKWNUUHSWGZ-QAFNWWFMSA-N 382746 US10273259, Example 455::US10711020, Example 455 Nuclear receptor ROR-gamma [262-507] 83.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382746 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382746&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678513 404852093 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931368 CS(=O)(=O)CCC(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C25H23F8NO5S2/c1-40(36,37)13-10-21(35)34-12-11-22(41(38,39)18-6-4-17(26)5-7-18)19-8-3-16(14-15(19)2-9-20(22)34)23(27,24(28,29)30)25(31,32)33/h3-8,14,20H,2,9-13H2,1H3/t20-,22-/m1/s1 BYYTWPXMJYJHDQ-IFMALSPDSA-N 382747 US10273259, Example 456::US10711020, Example 456 Nuclear receptor ROR-gamma [262-507] 27.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382747 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382747&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678668 404852094 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931369 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)CS(=O)(=O)c1ccc(Cl)cc1 InChI=1S/C29H22ClF8NO5S2/c30-19-3-7-21(8-4-19)45(41,42)16-25(40)39-14-13-26(46(43,44)22-9-5-20(31)6-10-22)23-11-2-18(15-17(23)1-12-24(26)39)27(32,28(33,34)35)29(36,37)38/h2-11,15,24H,1,12-14,16H2/t24-,26-/m1/s1 ZSLGDUXOGUBLDQ-AOYPEHQESA-N 382748 US10273259, Example 457::US10711020, Example 457 Nuclear receptor ROR-gamma [262-507] 76.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382748 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382748&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679175 404852095 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931370 Cc1ccc(cc1)S(=O)(=O)CCC(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C31H27F8NO5S2/c1-19-2-8-23(9-3-19)46(42,43)17-14-27(41)40-16-15-28(47(44,45)24-10-6-22(32)7-11-24)25-12-5-21(18-20(25)4-13-26(28)40)29(33,30(34,35)36)31(37,38)39/h2-3,5-12,18,26H,4,13-17H2,1H3/t26-,28-/m1/s1 RPLMWNRMFNEEOY-IXCJQBJRSA-N 382749 US10273259, Example 458::US10711020, Example 458 Nuclear receptor ROR-gamma [262-507] 101 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382749 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382749&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678670 404852096 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931371 NC(C1CCS(=O)(=O)CC1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H28F8N2O5S2/c29-19-3-5-20(6-4-19)45(42,43)25-11-12-38(24(39)23(37)16-9-13-44(40,41)14-10-16)22(25)8-1-17-15-18(2-7-21(17)25)26(30,27(31,32)33)28(34,35)36/h2-7,15-16,22-23H,1,8-14,37H2/t22-,23?,25-/m1/s1 PSFKEQFCQTZZHB-VJBIEYCASA-N 382750 US10273259, Example 459::US10711020, Example 459 Nuclear receptor ROR-gamma [262-507] 64.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382750 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382750&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679148 404852097 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931372 CC(=O)NC(C1CCS(=O)(=O)CC1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C30H30F8N2O6S2/c1-17(41)39-25(18-10-14-47(43,44)15-11-18)26(42)40-13-12-27(48(45,46)22-6-4-21(31)5-7-22)23-8-3-20(16-19(23)2-9-24(27)40)28(32,29(33,34)35)30(36,37)38/h3-8,16,18,24-25H,2,9-15H2,1H3,(H,39,41)/t24-,25?,27-/m1/s1 SUPJBGKWXGOUMU-PTYBVJFYSA-N 382751 US10273259, Example 460::US10273259, Example 461::US10711020, Example 461 Nuclear receptor ROR-gamma [262-507] 30.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382751 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382751&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678452 404852098 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931373 CC(=O)NC(C1CCS(=O)(=O)CC1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C30H30F8N2O6S2/c1-17(41)39-25(18-10-14-47(43,44)15-11-18)26(42)40-13-12-27(48(45,46)22-6-4-21(31)5-7-22)23-8-3-20(16-19(23)2-9-24(27)40)28(32,29(33,34)35)30(36,37)38/h3-8,16,18,24-25H,2,9-15H2,1H3,(H,39,41)/t24-,25?,27-/m1/s1 SUPJBGKWXGOUMU-PTYBVJFYSA-N 382751 US10273259, Example 460::US10273259, Example 461::US10711020, Example 461 Nuclear receptor ROR-gamma [262-507] 68.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382751 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382751&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678452 404852098 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931374 OCC(=O)NC(C1CCS(=O)(=O)CC1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C30H30F8N2O7S2/c31-20-3-5-21(6-4-20)49(46,47)27-11-12-40(26(43)25(39-24(42)16-41)17-9-13-48(44,45)14-10-17)23(27)8-1-18-15-19(2-7-22(18)27)28(32,29(33,34)35)30(36,37)38/h2-7,15,17,23,25,41H,1,8-14,16H2,(H,39,42)/t23-,25?,27-/m1/s1 PQMIEJDNNYHWBW-TXQBPDISSA-N 382753 US10273259, Example 462::US10711020, Example 462 Nuclear receptor ROR-gamma [262-507] 59.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382753 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382753&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678939 404852099 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931375 NC1(CCC1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C26H24F8N2O3S/c27-17-4-6-18(7-5-17)40(38,39)23-12-13-36(21(37)22(35)10-1-11-22)20(23)9-2-15-14-16(3-8-19(15)23)24(28,25(29,30)31)26(32,33)34/h3-8,14,20H,1-2,9-13,35H2/t20-,23-/m1/s1 DHGVZZVMUBPXJT-NFBKMPQASA-N 382754 US10273259, Example 463::US10711020, Example 463 Nuclear receptor ROR-gamma [262-507] 37.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382754 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382754&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678973 404852100 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931376 CC(O)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C24H21F8NO4S/c1-13(34)20(35)33-11-10-21(38(36,37)17-6-4-16(25)5-7-17)18-8-3-15(12-14(18)2-9-19(21)33)22(26,23(27,28)29)24(30,31)32/h3-8,12-13,19,34H,2,9-11H2,1H3/t13?,19-,21-/m1/s1 BRORFVNRYCQKTI-BTSGLNRLSA-N 382755 US10273259, Example 464::US10711020, Example 464 Nuclear receptor ROR-gamma [262-507] 23.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382755 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382755&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678654 404852101 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931377 O[C@H](C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1)C(F)(F)F InChI=1S/C24H18F11NO4S/c25-14-3-5-15(6-4-14)41(39,40)20-9-10-36(19(38)18(37)22(27,28)29)17(20)8-1-12-11-13(2-7-16(12)20)21(26,23(30,31)32)24(33,34)35/h2-7,11,17-18,37H,1,8-10H2/t17-,18-,20-/m1/s1 XDCCRDKBCXJGQP-QWFCFKBJSA-N 382756 US10273259, Example 465::US10711020, Example 465 Nuclear receptor ROR-gamma [262-507] 53.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382756 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382756&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678681 404852102 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931378 C[C@@](O)(C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1)C(F)(F)F InChI=1S/C25H20F11NO4S/c1-20(39,23(28,29)30)19(38)37-11-10-21(42(40,41)16-6-4-15(26)5-7-16)17-8-3-14(12-13(17)2-9-18(21)37)22(27,24(31,32)33)25(34,35)36/h3-8,12,18,39H,2,9-11H2,1H3/t18-,20-,21-/m1/s1 NKKSYHKSTOWHIH-HMXCVIKNSA-N 382757 US10273259, Example 466::US10711020, Example 466 Nuclear receptor ROR-gamma [262-507] 28.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382757 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382757&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679166 404852103 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931379 CCC(C)(O)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C26H25F8NO4S/c1-3-22(2,37)21(36)35-13-12-23(40(38,39)18-8-6-17(27)7-9-18)19-10-5-16(14-15(19)4-11-20(23)35)24(28,25(29,30)31)26(32,33)34/h5-10,14,20,37H,3-4,11-13H2,1-2H3/t20-,22?,23-/m1/s1 UXFWEECXIIFGOQ-WPLVIQRKSA-N 382758 US10273259, Example 467::US10711020, Example 467 Nuclear receptor ROR-gamma [262-507] 50.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382758 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382758&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678756 404852104 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931380 OC1(CCCCC1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H27F8NO4S/c29-19-6-8-20(9-7-19)42(40,41)25-14-15-37(23(38)24(39)12-2-1-3-13-24)22(25)11-4-17-16-18(5-10-21(17)25)26(30,27(31,32)33)28(34,35)36/h5-10,16,22,39H,1-4,11-15H2/t22-,25-/m1/s1 RAFFAZLEYOPBCR-RCZVLFRGSA-N 382759 US10273259, Example 468::US10711020, Example 468 Nuclear receptor ROR-gamma [262-507] 22.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382759 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382759&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679170 404852105 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931381 OC(C1CCOCC1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H27F8NO5S/c29-19-3-5-20(6-4-19)43(40,41)25-11-12-37(24(39)23(38)16-9-13-42-14-10-16)22(25)8-1-17-15-18(2-7-21(17)25)26(30,27(31,32)33)28(34,35)36/h2-7,15-16,22-23,38H,1,8-14H2/t22-,23?,25-/m1/s1 MGKWDVNKZNFTMG-VJBIEYCASA-N 382760 US10273259, Example 469::US10711020, Example 469 Nuclear receptor ROR-gamma [262-507] 21.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382760 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382760&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678958 404852106 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931382 OC1(CCC1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C26H23F8NO4S/c27-17-4-6-18(7-5-17)40(38,39)23-12-13-35(21(36)22(37)10-1-11-22)20(23)9-2-15-14-16(3-8-19(15)23)24(28,25(29,30)31)26(32,33)34/h3-8,14,20,37H,1-2,9-13H2/t20-,23-/m1/s1 CHTHFBQVPAHCST-NFBKMPQASA-N 382761 US10273259, Example 470::US10711020, Example 470 Nuclear receptor ROR-gamma [262-507] 25.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382761 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382761&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678975 404852107 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931383 OC1(CCOCC1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C27H25F8NO5S/c28-18-3-5-19(6-4-18)42(39,40)24-9-12-36(22(37)23(38)10-13-41-14-11-23)21(24)8-1-16-15-17(2-7-20(16)24)25(29,26(30,31)32)27(33,34)35/h2-7,15,21,38H,1,8-14H2/t21-,24-/m1/s1 QEUMJSPHXVPHCH-ZJSXRUAMSA-N 382762 US10273259, Example 471::US10711020, Example 471 Nuclear receptor ROR-gamma [262-507] 30.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382762 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382762&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122669279 404852108 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931384 OC1(CC1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C25H21F8NO4S/c26-16-3-5-17(6-4-16)39(37,38)22-11-12-34(20(35)21(36)9-10-21)19(22)8-1-14-13-15(2-7-18(14)22)23(27,24(28,29)30)25(31,32)33/h2-7,13,19,36H,1,8-12H2/t19-,22-/m1/s1 XHLRBPZQDLHCDE-DENIHFKCSA-N 382763 US10273259, Example 472::US10711020, Example 472 Nuclear receptor ROR-gamma [262-507] 25.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382763 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382763&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679032 404852109 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931385 CC(C)(C)[C@H](O)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C27H27F8NO4S/c1-23(2,3)21(37)22(38)36-13-12-24(41(39,40)18-8-6-17(28)7-9-18)19-10-5-16(14-15(19)4-11-20(24)36)25(29,26(30,31)32)27(33,34)35/h5-10,14,20-21,37H,4,11-13H2,1-3H3/t20-,21-,24-/m1/s1 KNSMXEWTUCOISP-PQNGQFLHSA-N 382764 US10273259, Example 473::US10711020, Example 473 Nuclear receptor ROR-gamma [262-507] 17.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382764 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382764&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678693 404852110 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931386 O[C@H](C1CCCCC1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C29H29F8NO4S/c30-20-8-10-21(11-9-20)43(41,42)26-14-15-38(25(40)24(39)17-4-2-1-3-5-17)23(26)13-6-18-16-19(7-12-22(18)26)27(31,28(32,33)34)29(35,36)37/h7-12,16-17,23-24,39H,1-6,13-15H2/t23-,24-,26-/m1/s1 LLEXHPCGSMBVED-DGWZTRNLSA-N 382765 US10273259, Example 474::US10711020, Example 474 Nuclear receptor ROR-gamma [262-507] 26.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382765 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382765&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678749 404852111 C03491 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931387 CC(C)(C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1)C(F)(F)F InChI=1S/C26H22F11NO3S/c1-21(2,24(29,30)31)20(39)38-12-11-22(42(40,41)17-7-5-16(27)6-8-17)18-9-4-15(13-14(18)3-10-19(22)38)23(28,25(32,33)34)26(35,36)37/h4-9,13,19H,3,10-12H2,1-2H3/t19-,22-/m1/s1 NPEVFGJGEHYCQW-DENIHFKCSA-N 382734 US10273259, Example 443::US10273259, Example 475::US10711020, Example 476 Nuclear receptor ROR-gamma [262-507] 19.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382734 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382734&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678665 404852081 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931388 CC(C)(C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1)C(F)(F)F InChI=1S/C26H22F11NO3S/c1-21(2,24(29,30)31)20(39)38-12-11-22(42(40,41)17-7-5-16(27)6-8-17)18-9-4-15(13-14(18)3-10-19(22)38)23(28,25(32,33)34)26(35,36)37/h4-9,13,19H,3,10-12H2,1-2H3/t19-,22-/m1/s1 NPEVFGJGEHYCQW-DENIHFKCSA-N 382734 US10273259, Example 443::US10273259, Example 475::US10711020, Example 476 Nuclear receptor ROR-gamma [262-507] 23.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382734 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382734&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678665 404852081 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931389 CCNS(=O)(=O)CCC(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C26H26F8N2O5S2/c1-2-35-42(38,39)14-11-22(37)36-13-12-23(43(40,41)19-7-5-18(27)6-8-19)20-9-4-17(15-16(20)3-10-21(23)36)24(28,25(29,30)31)26(32,33)34/h4-9,15,21,35H,2-3,10-14H2,1H3/t21-,23-/m1/s1 MHTYIQHQPSLEMR-FYYLOGMGSA-N 382768 US10273259, Example 477::US10711020, Example 477 Nuclear receptor ROR-gamma [262-507] 18.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382768 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382768&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679139 404852113 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931390 CC(=O)NC1(CCS(=O)(=O)CC1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C29H28F8N2O6S2/c1-17(40)38-25(11-14-46(42,43)15-12-25)24(41)39-13-10-26(47(44,45)21-6-4-20(30)5-7-21)22-8-3-19(16-18(22)2-9-23(26)39)27(31,28(32,33)34)29(35,36)37/h3-8,16,23H,2,9-15H2,1H3,(H,38,40)/t23-,26-/m1/s1 JIXDBABJZVFEGC-ZEQKJWHPSA-N 382769 US10273259, Example 478::US10711020, Example 478 Nuclear receptor ROR-gamma [262-507] 28.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382769 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382769&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678927 404852114 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931391 NC1(CCS(=O)(=O)CC1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C27H26F8N2O5S2/c28-18-3-5-19(6-4-18)44(41,42)24-9-12-37(22(38)23(36)10-13-43(39,40)14-11-23)21(24)8-1-16-15-17(2-7-20(16)24)25(29,26(30,31)32)27(33,34)35/h2-7,15,21H,1,8-14,36H2/t21-,24-/m1/s1 SEMDYPUEGFCPCQ-ZJSXRUAMSA-N 382770 US10273259, Example 479::US10711020, Example 479 Nuclear receptor ROR-gamma [262-507] 35.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382770 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382770&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678776 404852115 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931392 CC(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C23H19F8NO3S/c1-13(33)32-11-10-20(36(34,35)17-6-4-16(24)5-7-17)18-8-3-15(12-14(18)2-9-19(20)32)21(25,22(26,27)28)23(29,30)31/h3-8,12,19H,2,9-11H2,1H3/t19-,20-/m1/s1 TVONFWVDRJIBRS-WOJBJXKFSA-N 382771 US10273259, Example 482::US10711020, Example 482 Nuclear receptor ROR-gamma [262-507] 85.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382771 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382771&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679018 404852116 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931393 CCC(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C24H21F8NO3S/c1-2-20(34)33-12-11-21(37(35,36)17-7-5-16(25)6-8-17)18-9-4-15(13-14(18)3-10-19(21)33)22(26,23(27,28)29)24(30,31)32/h4-9,13,19H,2-3,10-12H2,1H3/t19-,21-/m1/s1 IMRSYMIEXNFKNZ-TZIWHRDSSA-N 382772 US10273259, Example 483::US10711020, Example 483 Nuclear receptor ROR-gamma [262-507] 92.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382772 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382772&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679053 404852117 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931394 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C=C InChI=1S/C24H19F8NO3S/c1-2-20(34)33-12-11-21(37(35,36)17-7-5-16(25)6-8-17)18-9-4-15(13-14(18)3-10-19(21)33)22(26,23(27,28)29)24(30,31)32/h2,4-9,13,19H,1,3,10-12H2/t19-,21-/m1/s1 PSSQOMQMODJTRZ-TZIWHRDSSA-N 382773 US10273259, Example 484::US10711020, Example 484 Nuclear receptor ROR-gamma [262-507] 98.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382773 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382773&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679165 404852118 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931395 CCC(C)(O)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C26H25F8NO4S/c1-3-22(2,37)21(36)35-13-12-23(40(38,39)18-8-6-17(27)7-9-18)19-10-5-16(14-15(19)4-11-20(23)35)24(28,25(29,30)31)26(32,33)34/h5-10,14,20,37H,3-4,11-13H2,1-2H3/t20-,22?,23-/m1/s1 UXFWEECXIIFGOQ-WPLVIQRKSA-N 382774 US10273259, Example 485::US10273259, Example 486::US10711020, Example 486 Nuclear receptor ROR-gamma [262-507] 36.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382774 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382774&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678756 404852119 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931396 CCC(C)(O)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C26H25F8NO4S/c1-3-22(2,37)21(36)35-13-12-23(40(38,39)18-8-6-17(27)7-9-18)19-10-5-16(14-15(19)4-11-20(23)35)24(28,25(29,30)31)26(32,33)34/h5-10,14,20,37H,3-4,11-13H2,1-2H3/t20-,22?,23-/m1/s1 UXFWEECXIIFGOQ-WPLVIQRKSA-N 382774 US10273259, Example 485::US10273259, Example 486::US10711020, Example 486 Nuclear receptor ROR-gamma [262-507] 51.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382774 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382774&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678756 404852119 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931397 OC(=O)C12CCC(CC1)(C2)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C30H27F8NO5S/c31-19-3-5-20(6-4-19)45(43,44)27-13-14-39(23(40)25-9-11-26(16-25,12-10-25)24(41)42)22(27)8-1-17-15-18(2-7-21(17)27)28(32,29(33,34)35)30(36,37)38/h2-7,15,22H,1,8-14,16H2,(H,41,42)/t22-,25?,26?,27-/m1/s1 ISVYIUNLJVBPHV-LPDNJITPSA-N 382776 US10273259, Example 487::US10711020, Example 487 Nuclear receptor ROR-gamma [262-507] 283 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382776 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382776&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678523 404852120 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931398 OC(=O)[C@@H]1[C@H]2C[C@@H](C[C@@H]12)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C29H25F8NO5S/c30-17-3-5-18(6-4-17)44(42,43)26-9-10-38(24(39)15-12-19-20(13-15)23(19)25(40)41)22(26)8-1-14-11-16(2-7-21(14)26)27(31,28(32,33)34)29(35,36)37/h2-7,11,15,19-20,22-23H,1,8-10,12-13H2,(H,40,41)/t15-,19-,20+,22-,23+,26-/m1/s1 UHLJJPHZGHFJLZ-UCCTXEPQSA-N 382777 US10273259, Example 488::US10711020, Example 488 Nuclear receptor ROR-gamma [262-507] 145 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382777 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382777&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678769 404852121 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931399 CCC[C@@]1(CC[C@@H](CC1)C(O)=O)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C32H33F8NO5S/c1-2-13-28(14-11-19(12-15-28)26(42)43)27(44)41-17-16-29(47(45,46)23-7-5-22(33)6-8-23)24-9-4-21(18-20(24)3-10-25(29)41)30(34,31(35,36)37)32(38,39)40/h4-9,18-19,25H,2-3,10-17H2,1H3,(H,42,43)/t19-,25-,28-,29-/m1/s1 CLXDXGGRGJNBCB-LNJOXGPJSA-N 382778 US10273259, Example 489::US10711020, Example 489 Nuclear receptor ROR-gamma [262-507] 438 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382778 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382778&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678688 404852122 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931400 COCC1(CCC(CC1)C(O)=O)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C31H31F8NO6S/c1-46-17-27(12-10-18(11-13-27)25(41)42)26(43)40-15-14-28(47(44,45)22-6-4-21(32)5-7-22)23-8-3-20(16-19(23)2-9-24(28)40)29(33,30(34,35)36)31(37,38)39/h3-8,16,18,24H,2,9-15,17H2,1H3,(H,41,42)/t18?,24-,27?,28-/m1/s1 CLSLHBGKFQLFSL-ISBMXXRTSA-N 453525 US10711020, Example 490 Nuclear receptor ROR-gamma [262-507] 195 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=453525 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=453525&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678698 440969426 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931401 OC(=O)C1(O)CCC(CC1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C29H27F8NO6S/c30-19-3-5-20(6-4-19)45(43,44)26-13-14-38(23(39)16-9-11-25(42,12-10-16)24(40)41)22(26)8-1-17-15-18(2-7-21(17)26)27(31,28(32,33)34)29(35,36)37/h2-7,15-16,22,42H,1,8-14H2,(H,40,41)/t16?,22-,25?,26-/m1/s1 UAAXXHYNFYTCMH-YLDCRMAMSA-N 453526 US10711020, Example 491 Nuclear receptor ROR-gamma [262-507] 121 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=453526 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=453526&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678699 440969427 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931402 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1CCOC1 InChI=1S/C26H23F8NO4S/c27-18-3-5-19(6-4-18)40(37,38)23-10-11-35(22(36)16-9-12-39-14-16)21(23)8-1-15-13-17(2-7-20(15)23)24(28,25(29,30)31)26(32,33)34/h2-7,13,16,21H,1,8-12,14H2/t16?,21-,23-/m1/s1 BKWHSBXYDDIEGE-KDTADFBSSA-N 382781 US10273259, Example 492::US10711020, Example 492 Nuclear receptor ROR-gamma [262-507] 52.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382781 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382781&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678703 404852125 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931403 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1(CCOCC1)C#N InChI=1S/C28H24F8N2O4S/c29-19-3-5-20(6-4-19)43(40,41)25-9-12-38(23(39)24(16-37)10-13-42-14-11-24)22(25)8-1-17-15-18(2-7-21(17)25)26(30,27(31,32)33)28(34,35)36/h2-7,15,22H,1,8-14H2/t22-,25-/m1/s1 DHERJBCEZJWWBP-RCZVLFRGSA-N 382782 US10273259, Example 493::US10711020, Example 493 Nuclear receptor ROR-gamma [262-507] 103 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382782 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382782&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678705 404852126 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931404 CN1[C@@H](C[C@H](O)C1=O)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C27H24F8N2O5S/c1-36-19(13-20(38)23(36)40)22(39)37-11-10-24(43(41,42)17-6-4-16(28)5-7-17)18-8-3-15(12-14(18)2-9-21(24)37)25(29,26(30,31)32)27(33,34)35/h3-8,12,19-21,38H,2,9-11,13H2,1H3/t19-,20-,21+,24+/m0/s1 KAKUQEOIEAWDFB-VMIIQTFKSA-N 382537 US10273259, Example 246::US10273259, Example 494::US10711020, Example 494 Nuclear receptor ROR-gamma [262-507] 23.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382537 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382537&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678788 404851898 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931405 C[C@H]1C[C@H](C[C@@H](C)S1(=O)=O)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C29H29F8NO5S2/c1-16-13-19(14-17(2)44(16,40)41)25(39)38-12-11-26(45(42,43)22-7-5-21(30)6-8-22)23-9-4-20(15-18(23)3-10-24(26)38)27(31,28(32,33)34)29(35,36)37/h4-9,15-17,19,24H,3,10-14H2,1-2H3/t16-,17+,19+,24-,26-/m1/s1 MQFDMIAESKMWEC-CHQNCTNHSA-N 382784 US10273259, Example 495::US10711020, Example 495 Nuclear receptor ROR-gamma [262-507] 64.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382784 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382784&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679149 404852127 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931406 OC1(CCNCC1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C27H26F8N2O4S/c28-18-3-5-19(6-4-18)42(40,41)24-11-14-37(22(38)23(39)9-12-36-13-10-23)21(24)8-1-16-15-17(2-7-20(16)24)25(29,26(30,31)32)27(33,34)35/h2-7,15,21,36,39H,1,8-14H2/t21-,24-/m1/s1 MSSLTMDBRWZWPK-ZJSXRUAMSA-N 382785 US10273259, Example 496::US10711020, Example 496 Nuclear receptor ROR-gamma [262-507] 77.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382785 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382785&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678981 404852128 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931407 C[C@H]1C[C@H](C[C@@H](C)S1(=O)=O)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(Cl)cc1 InChI=1S/C29H29ClF7NO5S2/c1-16-13-19(14-17(2)44(16,40)41)25(39)38-12-11-26(45(42,43)22-7-5-21(30)6-8-22)23-9-4-20(15-18(23)3-10-24(26)38)27(31,28(32,33)34)29(35,36)37/h4-9,15-17,19,24H,3,10-14H2,1-2H3/t16-,17+,19+,24?,26? ZEUUQSLMFOAELZ-XLSVLJSMSA-N 382786 US10273259, Example 497::US10711020, Example 497 Nuclear receptor ROR-gamma [262-507] 64.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382786 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382786&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679207 404852129 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931408 OCCN1[C@@H](C[C@H](F)C1=O)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H25F9N2O5S/c29-17-3-5-18(6-4-17)45(43,44)25-9-10-39(24(42)21-14-20(30)23(41)38(21)11-12-40)22(25)8-1-15-13-16(2-7-19(15)25)26(31,27(32,33)34)28(35,36)37/h2-7,13,20-22,40H,1,8-12,14H2/t20-,21-,22+,25+/m0/s1 OZWSYBBGXBLWCW-VRIJDZSUSA-N 382787 US10273259, Example 498::US10711020, Example 498 Nuclear receptor ROR-gamma [262-507] 42.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382787 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382787&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678678 404852130 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931409 FC(F)(F)C(F)(c1ccc2c(CCC3N(CCC23S(=O)(=O)c2ccc(Cl)cc2)C(=O)c2ccc3cncn3c2)c1)C(F)(F)F InChI=1S/C29H21ClF7N3O3S/c30-20-4-7-22(8-5-20)44(42,43)26-11-12-40(25(41)18-1-6-21-14-38-16-39(21)15-18)24(26)10-2-17-13-19(3-9-23(17)26)27(31,28(32,33)34)29(35,36)37/h1,3-9,13-16,24H,2,10-12H2 KPDGUAFDYQGWEV-UHFFFAOYSA-N 382788 US10273259, Example 499::US10711020, Example 499 Nuclear receptor ROR-gamma [262-507] 26.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382788 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382788&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679146 404852131 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931410 CC1(C)OC(=O)CC1C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H25F8NO5S/c1-24(2)20(14-22(38)42-24)23(39)37-12-11-25(43(40,41)18-7-5-17(29)6-8-18)19-9-4-16(13-15(19)3-10-21(25)37)26(30,27(31,32)33)28(34,35)36/h4-9,13,20-21H,3,10-12,14H2,1-2H3/t20?,21-,25-/m1/s1 LBTFXZSCWMJOLQ-NOCHFJEPSA-N 382789 US10273259, Example 500::US10711020, Example 500 Nuclear receptor ROR-gamma [262-507] 53.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382789 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382789&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679039 404852132 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931411 CC(C)C1CC(CCO1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C30H31F8NO4S/c1-17(2)24-16-19(11-14-43-24)26(40)39-13-12-27(44(41,42)22-7-5-21(31)6-8-22)23-9-4-20(15-18(23)3-10-25(27)39)28(32,29(33,34)35)30(36,37)38/h4-9,15,17,19,24-25H,3,10-14,16H2,1-2H3/t19?,24?,25-,27-/m1/s1 BJJKMASKHJPBMA-OTAHFMTBSA-N 382790 US10273259, Example 501::US10711020, Example 501 Nuclear receptor ROR-gamma [262-507] 37.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382790 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382790&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678712 404852133 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931412 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)c1ccc2cncn2c1 InChI=1S/C29H21F8N3O3S/c30-20-4-7-22(8-5-20)44(42,43)26-11-12-40(25(41)18-1-6-21-14-38-16-39(21)15-18)24(26)10-2-17-13-19(3-9-23(17)26)27(31,28(32,33)34)29(35,36)37/h1,3-9,13-16,24H,2,10-12H2/t24-,26-/m1/s1 RXUWLKZLOJWMFP-AOYPEHQESA-N 382791 US10273259, Example 502::US10711020, Example 502 Nuclear receptor ROR-gamma [262-507] 20.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382791 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382791&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678706 404852134 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931413 CO[C@H]1C[C@H](N(C)C1=O)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H26F8N2O5S/c1-37-20(14-21(43-2)24(37)40)23(39)38-12-11-25(44(41,42)18-7-5-17(29)6-8-18)19-9-4-16(13-15(19)3-10-22(25)38)26(30,27(31,32)33)28(34,35)36/h4-9,13,20-22H,3,10-12,14H2,1-2H3/t20-,21-,22+,25+/m0/s1 WQGALPRYPWUIGZ-VRIJDZSUSA-N 382792 US10273259, Example 503::US10711020, Example 503 Nuclear receptor ROR-gamma [262-507] 83.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382792 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382792&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678785 404852135 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931414 OC(=O)[C@H]1CC[C@@](F)(CC1)C(=O)N1CCCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C30H28F9NO5S/c31-20-4-6-21(7-5-20)46(44,45)27-12-1-15-40(25(43)26(32)13-10-17(11-14-26)24(41)42)23(27)9-2-18-16-19(3-8-22(18)27)28(33,29(34,35)36)30(37,38)39/h3-8,16-17,23H,1-2,9-15H2,(H,41,42)/t17-,23?,26+,27? XTHIANFXMPOKFF-MTOUGUCQSA-N 382793 US10273259, Example 504::US10711020, Example 504 Nuclear receptor ROR-gamma [262-507] 57.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382793 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382793&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678775 404852136 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931415 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)CN1CCS(=O)(=O)CC1 InChI=1S/C27H26F8N2O5S2/c28-19-3-5-20(6-4-19)44(41,42)24-9-10-37(23(38)16-36-11-13-43(39,40)14-12-36)22(24)8-1-17-15-18(2-7-21(17)24)25(29,26(30,31)32)27(33,34)35/h2-7,15,22H,1,8-14,16H2/t22-,24-/m1/s1 TUVYEZREOAAMDT-ISKFKSNPSA-N 382794 US10273259, Example 505::US10711020, Example 505 Nuclear receptor ROR-gamma [262-507] 88.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382794 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382794&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678802 404852137 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931416 Cc1cc(ccc1F)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)[C@@]1(O)CC[C@@H](CC1)C(O)=O InChI=1S/C30H29F8NO6S/c1-16-14-20(4-6-22(16)31)46(44,45)27-12-13-39(25(42)26(43)10-8-17(9-11-26)24(40)41)23(27)7-2-18-15-19(3-5-21(18)27)28(32,29(33,34)35)30(36,37)38/h3-6,14-15,17,23,43H,2,7-13H2,1H3,(H,40,41)/t17-,23?,26+,27? ZXRWJHQYBPGKEZ-MTOUGUCQSA-N 382795 US10273259, Example 506::US10711020, Example 506 Nuclear receptor ROR-gamma [262-507] 223 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382795 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382795&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679066 404852138 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931417 OC(=O)[C@H]1CC[C@@](F)(CC1)C(=O)N1CCCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1cccc(F)c1 InChI=1S/C30H28F9NO5S/c31-20-3-1-4-21(16-20)46(44,45)27-11-2-14-40(25(43)26(32)12-9-17(10-13-26)24(41)42)23(27)8-5-18-15-19(6-7-22(18)27)28(33,29(34,35)36)30(37,38)39/h1,3-4,6-7,15-17,23H,2,5,8-14H2,(H,41,42)/t17-,23?,26+,27? NUATZYDOTDTTAN-MTOUGUCQSA-N 382796 US10273259, Example 507::US10711020, Example 507 Nuclear receptor ROR-gamma [262-507] 135 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382796 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382796&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678793 404852139 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931418 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CCC2(C1CNc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H26F8N2O5S/c29-18-6-8-19(9-7-18)44(42,43)25-11-12-38(23(39)15-1-3-16(4-2-15)24(40)41)22(25)14-37-21-13-17(5-10-20(21)25)26(30,27(31,32)33)28(34,35)36/h5-10,13,15-16,22,37H,1-4,11-12,14H2,(H,40,41)/t15-,16-,22?,25? WCICLOUJTXBWJG-QAXNPQHNSA-N 382797 US10273259, Example 508::US10273259, Example 509::US10711020, Example 509 Nuclear receptor ROR-gamma [262-507] 2830 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382797 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382797&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122669120 404852140 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931419 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CCC2(C1CNc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H26F8N2O5S/c29-18-6-8-19(9-7-18)44(42,43)25-11-12-38(23(39)15-1-3-16(4-2-15)24(40)41)22(25)14-37-21-13-17(5-10-20(21)25)26(30,27(31,32)33)28(34,35)36/h5-10,13,15-16,22,37H,1-4,11-12,14H2,(H,40,41)/t15-,16-,22?,25? WCICLOUJTXBWJG-QAXNPQHNSA-N 382797 US10273259, Example 508::US10273259, Example 509::US10711020, Example 509 Nuclear receptor ROR-gamma [262-507] 255 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382797 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382797&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122669120 404852140 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931420 OC(=O)C12CCC(CC1)(CC2)C(=O)N1CCC2(C1CNc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C30H28F8N2O5S/c31-18-2-4-19(5-3-18)46(44,45)27-13-14-40(23(41)25-7-10-26(11-8-25,12-9-25)24(42)43)22(27)16-39-21-15-17(1-6-20(21)27)28(32,29(33,34)35)30(36,37)38/h1-6,15,22,39H,7-14,16H2,(H,42,43) QFRLKGZREPPACN-UHFFFAOYSA-N 382799 US10273259, Example 510::US10711020, Example 510 Nuclear receptor ROR-gamma [262-507] 79.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382799 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382799&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678989 404852141 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931421 OC(=O)[C@H]1CC[C@@](F)(CC1)C(=O)N1CCC2(C1CNc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H25F9N2O5S/c29-17-2-4-18(5-3-17)45(43,44)25-11-12-39(23(42)24(30)9-7-15(8-10-24)22(40)41)21(25)14-38-20-13-16(1-6-19(20)25)26(31,27(32,33)34)28(35,36)37/h1-6,13,15,21,38H,7-12,14H2,(H,40,41)/t15-,21?,24+,25? JGWWDXLCSKKCJX-DNNXONSASA-N 382800 US10273259, Example 511::US10711020, Example 511 Nuclear receptor ROR-gamma [262-507] 41.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382800 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382800&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678747 404852142 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931422 C[C@@]1(CC[C@@H](CC1)C(O)=O)C(=O)N1CCC2(C1CNc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C29H28F8N2O5S/c1-25(10-8-16(9-11-25)23(40)41)24(42)39-13-12-26(45(43,44)19-5-3-18(30)4-6-19)20-7-2-17(14-21(20)38-15-22(26)39)27(31,28(32,33)34)29(35,36)37/h2-7,14,16,22,38H,8-13,15H2,1H3,(H,40,41)/t16-,22?,25-,26? UKOMWKQXEVTTJY-FVSSTLBOSA-N 382801 US10273259, Example 512::US10711020, Example 512 Nuclear receptor ROR-gamma [262-507] 22.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382801 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382801&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679206 404852143 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931423 CN1[C@@H](C[C@H](F)C1=O)C(=O)N1CCC2(C1CNc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1cccc(F)c1 InChI=1S/C26H22F9N3O4S/c1-37-19(11-17(28)21(37)39)22(40)38-8-7-23(43(41,42)15-4-2-3-14(27)10-15)16-6-5-13(9-18(16)36-12-20(23)38)24(29,25(30,31)32)26(33,34)35/h2-6,9-10,17,19-20,36H,7-8,11-12H2,1H3/t17-,19-,20?,23?/m0/s1 RXUZMAZHAXJPIV-CRJYNEJLSA-N 382802 US10273259, Example 513::US10273259, Example 522::US10711020, Example 522 Nuclear receptor ROR-gamma [262-507] 6561 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382802 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382802&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 145995603 404852144 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931424 FC(F)(F)C(F)(c1ccc2c(NCC3N(CCC23S(=O)(=O)c2ccccc2)C(=O)C2CCS(=O)(=O)CC2)c1)C(F)(F)F InChI=1S/C26H25F7N2O5S2/c27-24(25(28,29)30,26(31,32)33)17-6-7-19-20(14-17)34-15-21-23(19,42(39,40)18-4-2-1-3-5-18)10-11-35(21)22(36)16-8-12-41(37,38)13-9-16/h1-7,14,16,21,34H,8-13,15H2 DYCBUGGWOSQUOL-UHFFFAOYSA-N 382803 US10273259, Example 514::US10711020, Example 514 Nuclear receptor ROR-gamma [262-507] 181 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382803 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382803&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679195 404852145 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931425 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CCC2(C1CNc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccccc1 InChI=1S/C28H27F7N2O5S/c29-26(27(30,31)32,28(33,34)35)18-10-11-20-21(14-18)36-15-22-25(20,43(41,42)19-4-2-1-3-5-19)12-13-37(22)23(38)16-6-8-17(9-7-16)24(39)40/h1-5,10-11,14,16-17,22,36H,6-9,12-13,15H2,(H,39,40)/t16-,17-,22?,25? QBTRKYWHRBQCJR-FECXEKGZSA-N 382804 US10273259, Example 515::US10711020, Example 515 Nuclear receptor ROR-gamma [262-507] 56.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382804 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382804&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679194 404852146 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931426 Fc1ccc(cc1)S(=O)(=O)C12CCN(C1CNc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1CCS(=O)(=O)CC1 InChI=1S/C26H24F8N2O5S2/c27-17-2-4-18(5-3-17)43(40,41)23-9-10-36(22(37)15-7-11-42(38,39)12-8-15)21(23)14-35-20-13-16(1-6-19(20)23)24(28,25(29,30)31)26(32,33)34/h1-6,13,15,21,35H,7-12,14H2 KFFBIMNAYRQYFV-UHFFFAOYSA-N 382805 US10273259, Example 516::US10711020, Example 516 Nuclear receptor ROR-gamma [262-507] 15.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382805 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382805&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678759 404852147 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931427 Fc1cccc(c1)S(=O)(=O)C12CCN(C1CNc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1CCS(=O)(=O)CC1 InChI=1S/C26H24F8N2O5S2/c27-17-2-1-3-18(13-17)43(40,41)23-8-9-36(22(37)15-6-10-42(38,39)11-7-15)21(23)14-35-20-12-16(4-5-19(20)23)24(28,25(29,30)31)26(32,33)34/h1-5,12-13,15,21,35H,6-11,14H2 SRKHSAMWTXLEMM-UHFFFAOYSA-N 382806 US10273259, Example 517::US10711020, Example 517 Nuclear receptor ROR-gamma [262-507] 17.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382806 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382806&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678812 404852148 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931428 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CCC2(C1CNc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1cccc(F)c1 InChI=1S/C28H26F8N2O5S/c29-18-2-1-3-19(13-18)44(42,43)25-10-11-38(23(39)15-4-6-16(7-5-15)24(40)41)22(25)14-37-21-12-17(8-9-20(21)25)26(30,27(31,32)33)28(34,35)36/h1-3,8-9,12-13,15-16,22,37H,4-7,10-11,14H2,(H,40,41)/t15-,16-,22?,25? FWPGKAUITXDJLS-QAXNPQHNSA-N 382807 US10273259, Example 518::US10711020, Example 518 Nuclear receptor ROR-gamma [262-507] 47.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382807 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382807&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678746 404852149 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931429 OC(=O)[C@H]1CC[C@@](F)(CC1)C(=O)N1CCC2(C1CNc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccccc1 InChI=1S/C28H26F8N2O5S/c29-24(10-8-16(9-11-24)22(39)40)23(41)38-13-12-25(44(42,43)18-4-2-1-3-5-18)19-7-6-17(14-20(19)37-15-21(25)38)26(30,27(31,32)33)28(34,35)36/h1-7,14,16,21,37H,8-13,15H2,(H,39,40)/t16-,21?,24+,25? MXUDQHQOLWHXLA-QNINJKENSA-N 382808 US10273259, Example 519::US10711020, Example 519 Nuclear receptor ROR-gamma [262-507] 41.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382808 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382808&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679185 404852150 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931430 OC(=O)[C@@]1(F)CC[C@@H](CC1)C(=O)N1CCC2(C1CNc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccccc1 InChI=1S/C28H26F8N2O5S/c29-24(23(40)41)10-8-16(9-11-24)22(39)38-13-12-25(44(42,43)18-4-2-1-3-5-18)19-7-6-17(14-20(19)37-15-21(25)38)26(30,27(31,32)33)28(34,35)36/h1-7,14,16,21,37H,8-13,15H2,(H,40,41)/t16-,21?,24+,25? URBJYOLSRMRGDO-QNINJKENSA-N 382809 US10273259, Example 520::US10711020, Example 520 Nuclear receptor ROR-gamma [262-507] 57.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382809 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382809&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679021 404852151 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931431 OC(=O)[C@H]1CC[C@@](F)(CC1)C(=O)N1CCC2(C1CNc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1cccc(F)c1 InChI=1S/C28H25F9N2O5S/c29-17-2-1-3-18(13-17)45(43,44)25-10-11-39(23(42)24(30)8-6-15(7-9-24)22(40)41)21(25)14-38-20-12-16(4-5-19(20)25)26(31,27(32,33)34)28(35,36)37/h1-5,12-13,15,21,38H,6-11,14H2,(H,40,41)/t15-,21?,24+,25? JFWYSTSNUZXKCJ-DNNXONSASA-N 382810 US10273259, Example 521::US10711020, Example 521 Nuclear receptor ROR-gamma [262-507] 26.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382810 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382810&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678796 404852152 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931432 CN1[C@@H](C[C@H](F)C1=O)C(=O)N1CCC2(C1CNc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1cccc(F)c1 InChI=1S/C26H22F9N3O4S/c1-37-19(11-17(28)21(37)39)22(40)38-8-7-23(43(41,42)15-4-2-3-14(27)10-15)16-6-5-13(9-18(16)36-12-20(23)38)24(29,25(30,31)32)26(33,34)35/h2-6,9-10,17,19-20,36H,7-8,11-12H2,1H3/t17-,19-,20?,23?/m0/s1 RXUZMAZHAXJPIV-CRJYNEJLSA-N 382802 US10273259, Example 513::US10273259, Example 522::US10711020, Example 522 Nuclear receptor ROR-gamma [262-507] 18.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382802 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382802&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 145995603 404852144 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931433 OC1(CCS(=O)(=O)CC1)C(=O)N1CCC2(C1CNc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C26H24F8N2O6S2/c27-16-2-4-17(5-3-16)44(41,42)23-7-10-36(21(37)22(38)8-11-43(39,40)12-9-22)20(23)14-35-19-13-15(1-6-18(19)23)24(28,25(29,30)31)26(32,33)34/h1-6,13,20,35,38H,7-12,14H2 JVTKTQZHQLEDDU-UHFFFAOYSA-N 382812 US10273259, Example 523::US10711020, Example 523 Nuclear receptor ROR-gamma [262-507] 45.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382812 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382812&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678807 404852153 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931434 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CCC2(C1CNc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(Cl)cc1 InChI=1S/C28H26ClF7N2O5S/c29-18-6-8-19(9-7-18)44(42,43)25-11-12-38(23(39)15-1-3-16(4-2-15)24(40)41)22(25)14-37-21-13-17(5-10-20(21)25)26(30,27(31,32)33)28(34,35)36/h5-10,13,15-16,22,37H,1-4,11-12,14H2,(H,40,41)/t15-,16-,22?,25? SWBVPOIJKDRFCY-QAXNPQHNSA-N 382813 US10273259, Example 524::US10711020, Example 524 Nuclear receptor ROR-gamma [262-507] 71.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382813 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382813&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679055 404852154 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931435 OC(=O)C1CCC(C1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H25F8NO5S/c29-19-5-7-20(8-6-19)43(41,42)25-11-12-37(23(38)16-1-2-17(13-16)24(39)40)22(25)10-3-15-14-18(4-9-21(15)25)26(30,27(31,32)33)28(34,35)36/h4-9,14,16-17,22H,1-3,10-13H2,(H,39,40)/t16?,17?,22-,25-/m1/s1 XRRXYBCURUVMRW-AZNPCEPYSA-N 382699 US10273259, Example 408::US10273259, Example 525::US10273259, Example 526::US10273259, Example 527::US10273259, Example 528::US10711020, Example 528 Nuclear receptor ROR-gamma [262-507] 319 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382699 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382699&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678527 404852047 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931436 OC(=O)C1CCC(C1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H25F8NO5S/c29-19-5-7-20(8-6-19)43(41,42)25-11-12-37(23(38)16-1-2-17(13-16)24(39)40)22(25)10-3-15-14-18(4-9-21(15)25)26(30,27(31,32)33)28(34,35)36/h4-9,14,16-17,22H,1-3,10-13H2,(H,39,40)/t16?,17?,22-,25-/m1/s1 XRRXYBCURUVMRW-AZNPCEPYSA-N 382699 US10273259, Example 408::US10273259, Example 525::US10273259, Example 526::US10273259, Example 527::US10273259, Example 528::US10711020, Example 528 Nuclear receptor ROR-gamma [262-507] 98.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382699 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382699&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678527 404852047 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931437 OC(=O)C1CCC(C1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H25F8NO5S/c29-19-5-7-20(8-6-19)43(41,42)25-11-12-37(23(38)16-1-2-17(13-16)24(39)40)22(25)10-3-15-14-18(4-9-21(15)25)26(30,27(31,32)33)28(34,35)36/h4-9,14,16-17,22H,1-3,10-13H2,(H,39,40)/t16?,17?,22-,25-/m1/s1 XRRXYBCURUVMRW-AZNPCEPYSA-N 382699 US10273259, Example 408::US10273259, Example 525::US10273259, Example 526::US10273259, Example 527::US10273259, Example 528::US10711020, Example 528 Nuclear receptor ROR-gamma [262-507] 398 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382699 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382699&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678527 404852047 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931438 OC(=O)C1CCC(C1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H25F8NO5S/c29-19-5-7-20(8-6-19)43(41,42)25-11-12-37(23(38)16-1-2-17(13-16)24(39)40)22(25)10-3-15-14-18(4-9-21(15)25)26(30,27(31,32)33)28(34,35)36/h4-9,14,16-17,22H,1-3,10-13H2,(H,39,40)/t16?,17?,22-,25-/m1/s1 XRRXYBCURUVMRW-AZNPCEPYSA-N 382699 US10273259, Example 408::US10273259, Example 525::US10273259, Example 526::US10273259, Example 527::US10273259, Example 528::US10711020, Example 528 Nuclear receptor ROR-gamma [262-507] 225 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382699 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382699&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678527 404852047 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931439 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)[C@@H]1CCCC(=O)N1 InChI=1S/C27H24F8N2O4S/c28-17-6-8-18(9-7-17)42(40,41)24-12-13-37(23(39)20-2-1-3-22(38)36-20)21(24)11-4-15-14-16(5-10-19(15)24)25(29,26(30,31)32)27(33,34)35/h5-10,14,20-21H,1-4,11-13H2,(H,36,38)/t20-,21+,24+/m0/s1 YWYKJGNVVRTMPM-YZUZCNPQSA-N 382818 US10273259, Example 529::US10711020, Example 529 Nuclear receptor ROR-gamma [262-507] 199 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382818 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382818&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679052 404852155 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931440 Cc1cc(ccc1F)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1CCc2cncn2C1 InChI=1S/C30H27F8N3O3S/c1-17-12-22(6-8-24(17)31)45(43,44)27-10-11-41(26(42)19-2-5-21-14-39-16-40(21)15-19)25(27)9-3-18-13-20(4-7-23(18)27)28(32,29(33,34)35)30(36,37)38/h4,6-8,12-14,16,19,25H,2-3,5,9-11,15H2,1H3 YYFZFMGYDXVYSC-UHFFFAOYSA-N 382819 US10273259, Example 530::US10711020, Example 530 Nuclear receptor ROR-gamma [262-507] 195 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382819 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382819&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679187 404852156 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931441 Cc1cc(ccc1F)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1(O)CCS(=O)(=O)CC1 InChI=1S/C28H27F8NO6S2/c1-16-14-19(4-6-21(16)29)45(42,43)25-8-11-37(23(38)24(39)9-12-44(40,41)13-10-24)22(25)7-2-17-15-18(3-5-20(17)25)26(30,27(31,32)33)28(34,35)36/h3-6,14-15,22,39H,2,7-13H2,1H3 IXWIZXVKHKHMQW-UHFFFAOYSA-N 382820 US10273259, Example 531::US10711020, Example 531 Nuclear receptor ROR-gamma [262-507] 3665 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382820 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382820&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 145995604 404852157 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931442 CN1[C@@H](C[C@H](F)C1=O)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)c(C)c1 InChI=1S/C28H25F9N2O4S/c1-14-11-17(5-7-19(14)29)44(42,43)25-9-10-39(24(41)21-13-20(30)23(40)38(21)2)22(25)8-3-15-12-16(4-6-18(15)25)26(31,27(32,33)34)28(35,36)37/h4-7,11-12,20-22H,3,8-10,13H2,1-2H3/t20-,21-,22?,25?/m0/s1 NOEIOULRAQWJSY-GFOXRHNOSA-N 382821 US10273259, Example 532::US10711020, Example 532 Nuclear receptor ROR-gamma [262-507] 300 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382821 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382821&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 145995605 404852158 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931443 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1CCc2cncn2C1 InChI=1S/C29H25F8N3O3S/c30-20-4-7-22(8-5-20)44(42,43)26-11-12-40(25(41)18-1-6-21-14-38-16-39(21)15-18)24(26)10-2-17-13-19(3-9-23(17)26)27(31,28(32,33)34)29(35,36)37/h3-5,7-9,13-14,16,18,24H,1-2,6,10-12,15H2/t18?,24-,26-/m1/s1 SQFZAZHMXJWPGC-DLJUAZHHSA-N 382822 US10273259, Example 533::US10711020, Example 533 Nuclear receptor ROR-gamma [262-507] 229 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382822 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382822&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678980 404852159 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931444 FC(F)(F)C(F)(c1ccc2c(CCC3N(CCC23S(=O)(=O)c2ccc(Cl)cc2)C(=O)C2CCc3cncn3C2)c1)C(F)(F)F InChI=1S/C29H25ClF7N3O3S/c30-20-4-7-22(8-5-20)44(42,43)26-11-12-40(25(41)18-1-6-21-14-38-16-39(21)15-18)24(26)10-2-17-13-19(3-9-23(17)26)27(31,28(32,33)34)29(35,36)37/h3-5,7-9,13-14,16,18,24H,1-2,6,10-12,15H2 RIDYVJBZVCYZAI-UHFFFAOYSA-N 382823 US10273259, Example 534::US10711020, Example 534 Nuclear receptor ROR-gamma [262-507] 171 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382823 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382823&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 132123681 404852160 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931445 FC(F)(F)C(F)(c1ccc2c(NCC3N(CCC23S(=O)(=O)c2ccc(Cl)cc2)C(=O)C2CCS(=O)(=O)CC2)c1)C(F)(F)F InChI=1S/C26H24ClF7N2O5S2/c27-17-2-4-18(5-3-17)43(40,41)23-9-10-36(22(37)15-7-11-42(38,39)12-8-15)21(23)14-35-20-13-16(1-6-19(20)23)24(28,25(29,30)31)26(32,33)34/h1-6,13,15,21,35H,7-12,14H2 OECAWTKNBIXUDZ-UHFFFAOYSA-N 382824 US10273259, Example 535::US10711020, Example 535 Nuclear receptor ROR-gamma [262-507] 255 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382824 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382824&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679226 404852161 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931446 Fc1ccc(cc1F)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1CCS(=O)(=O)CC1 InChI=1S/C27H24F9NO5S2/c28-20-5-3-18(14-21(20)29)44(41,42)24-9-10-37(23(38)15-7-11-43(39,40)12-8-15)22(24)6-1-16-13-17(2-4-19(16)24)25(30,26(31,32)33)27(34,35)36/h2-5,13-15,22H,1,6-12H2 KSCQGPXLTGZRQC-UHFFFAOYSA-N 382825 US10273259, Example 536::US10711020, Example 536 Nuclear receptor ROR-gamma [262-507] 126 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382825 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382825&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678708 404852162 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931447 CN1[C@@H](CCCC1=O)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H26F8N2O4S/c1-37-21(3-2-4-23(37)39)24(40)38-14-13-25(43(41,42)19-9-7-18(29)8-10-19)20-11-6-17(15-16(20)5-12-22(25)38)26(30,27(31,32)33)28(34,35)36/h6-11,15,21-22H,2-5,12-14H2,1H3/t21-,22+,25+/m0/s1 MFQXWARSIFLBTN-SGIRGMQISA-N 383158 US10273259, Example 869::US10711020, Example 869 Nuclear receptor ROR-gamma [262-507] 242 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383158 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383158&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679285 404852454 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931448 OC1(CCS(=O)(=O)CC1)C(=O)N1CCC2(C1CNc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(Cl)cc1 InChI=1S/C26H24ClF7N2O6S2/c27-16-2-4-17(5-3-16)44(41,42)23-7-10-36(21(37)22(38)8-11-43(39,40)12-9-22)20(23)14-35-19-13-15(1-6-18(19)23)24(28,25(29,30)31)26(32,33)34/h1-6,13,20,35,38H,7-12,14H2 TXAUZPGQEKMCER-UHFFFAOYSA-N 382827 US10273259, Example 538::US10711020, Example 538 Nuclear receptor ROR-gamma [262-507] 493 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382827 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382827&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679157 404852164 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931449 FC(F)(F)C(F)(c1ccc2c(CC3N(CCC23S(=O)(=O)c2ccc(Cl)cc2)C(=O)C2CCS(=O)(=O)CC2)c1)C(F)(F)F InChI=1S/C26H23ClF7NO5S2/c27-18-2-4-19(5-3-18)42(39,40)23-9-10-35(22(36)15-7-11-41(37,38)12-8-15)21(23)14-16-13-17(1-6-20(16)23)24(28,25(29,30)31)26(32,33)34/h1-6,13,15,21H,7-12,14H2 AIPFWJCSQFWTFH-UHFFFAOYSA-N 382828 US10273259, Example 539::US10711020, Example 539 Nuclear receptor ROR-gamma [262-507] 197 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382828 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382828&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679024 404852165 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931450 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CCC2(C1Cc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(Cl)cc1 InChI=1S/C28H25ClF7NO5S/c29-19-6-8-20(9-7-19)43(41,42)25-11-12-37(23(38)15-1-3-16(4-2-15)24(39)40)22(25)14-17-13-18(5-10-21(17)25)26(30,27(31,32)33)28(34,35)36/h5-10,13,15-16,22H,1-4,11-12,14H2,(H,39,40)/t15-,16-,22?,25? POHKWRAGFPBKAK-QAXNPQHNSA-N 382829 US10273259, Example 540::US10711020, Example 540 Nuclear receptor ROR-gamma [262-507] 251 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382829 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382829&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679225 404852166 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931451 CC(C)(O)CC(=O)N1CCC2(C1Cc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(Cl)cc1 InChI=1S/C25H23ClF7NO4S/c1-21(2,36)13-20(35)34-10-9-22(39(37,38)17-6-4-16(26)5-7-17)18-8-3-15(11-14(18)12-19(22)34)23(27,24(28,29)30)25(31,32)33/h3-8,11,19,36H,9-10,12-13H2,1-2H3 BWQBUMBPZBLPPD-UHFFFAOYSA-N 382830 US10273259, Example 541::US10711020, Example 541 Nuclear receptor ROR-gamma [262-507] 93.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382830 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382830&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679201 404852167 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931452 OC(=O)[C@H]1CC[C@@](O)(CC1)C(=O)N1CCC2(C1Cc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(Cl)cc1 InChI=1S/C28H25ClF7NO6S/c29-18-2-4-19(5-3-18)44(42,43)25-11-12-37(23(40)24(41)9-7-15(8-10-24)22(38)39)21(25)14-16-13-17(1-6-20(16)25)26(30,27(31,32)33)28(34,35)36/h1-6,13,15,21,41H,7-12,14H2,(H,38,39)/t15-,21?,24+,25? RXNKBJPLEKIJDK-DNNXONSASA-N 382831 US10273259, Example 542::US10711020, Example 542 Nuclear receptor ROR-gamma [262-507] 74.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382831 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382831&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679027 404852168 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931453 C[C@@]1(CC[C@@H](CC1)C(O)=O)C(=O)N1CCC2(C1Cc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(Cl)cc1 InChI=1S/C29H27ClF7NO5S/c1-25(10-8-16(9-11-25)23(39)40)24(41)38-13-12-26(44(42,43)20-5-3-19(30)4-6-20)21-7-2-18(14-17(21)15-22(26)38)27(31,28(32,33)34)29(35,36)37/h2-7,14,16,22H,8-13,15H2,1H3,(H,39,40)/t16-,22?,25-,26? QEFRQORVGXHVSQ-FVSSTLBOSA-N 382832 US10273259, Example 543::US10711020, Example 543 Nuclear receptor ROR-gamma [262-507] 29.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382832 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382832&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678689 404852169 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931454 OC(=O)C12CCC(CC1)(CC2)C(=O)N1CCC2(C1Cc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(Cl)cc1 InChI=1S/C30H27ClF7NO5S/c31-19-2-4-20(5-3-19)45(43,44)27-13-14-39(23(40)25-7-10-26(11-8-25,12-9-25)24(41)42)22(27)16-17-15-18(1-6-21(17)27)28(32,29(33,34)35)30(36,37)38/h1-6,15,22H,7-14,16H2,(H,41,42) XPOIVGVPIRPYLP-UHFFFAOYSA-N 382833 US10273259, Example 544::US10711020, Example 544 Nuclear receptor ROR-gamma [262-507] 714 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382833 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382833&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679205 404852170 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931455 OC(=O)[C@H]1CC[C@@](F)(CC1)C(=O)N1CCC2(C1Cc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(Cl)cc1 InChI=1S/C28H24ClF8NO5S/c29-18-2-4-19(5-3-18)44(42,43)25-11-12-38(23(41)24(30)9-7-15(8-10-24)22(39)40)21(25)14-16-13-17(1-6-20(16)25)26(31,27(32,33)34)28(35,36)37/h1-6,13,15,21H,7-12,14H2,(H,39,40)/t15-,21?,24+,25? FSBPPGBHNXUWQC-DNNXONSASA-N 382834 US10273259, Example 545::US10711020, Example 545 Nuclear receptor ROR-gamma [262-507] 56.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382834 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382834&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678987 404852171 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931456 Fc1ccc(cc1)S(=O)(=O)C12CCN(C1Cc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1CCS(=O)(=O)CC1 InChI=1S/C26H23F8NO5S2/c27-18-2-4-19(5-3-18)42(39,40)23-9-10-35(22(36)15-7-11-41(37,38)12-8-15)21(23)14-16-13-17(1-6-20(16)23)24(28,25(29,30)31)26(32,33)34/h1-6,13,15,21H,7-12,14H2 RWBIIUWUMKJGDR-UHFFFAOYSA-N 382835 US10273259, Example 546::US10273259, Example 547::US10711020, Example 547 Nuclear receptor ROR-gamma [262-507] 105 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382835 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382835&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678811 404852172 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931457 Fc1ccc(cc1)S(=O)(=O)C12CCN(C1Cc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1CCS(=O)(=O)CC1 InChI=1S/C26H23F8NO5S2/c27-18-2-4-19(5-3-18)42(39,40)23-9-10-35(22(36)15-7-11-41(37,38)12-8-15)21(23)14-16-13-17(1-6-20(16)23)24(28,25(29,30)31)26(32,33)34/h1-6,13,15,21H,7-12,14H2 RWBIIUWUMKJGDR-UHFFFAOYSA-N 382835 US10273259, Example 546::US10273259, Example 547::US10711020, Example 547 Nuclear receptor ROR-gamma [262-507] 9193 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382835 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382835&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678811 404852172 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931458 CN1[C@@H](CCC1=O)C(=O)N1CCC2(C1Cc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C26H22F8N2O4S/c1-35-19(8-9-21(35)37)22(38)36-11-10-23(41(39,40)17-5-3-16(27)4-6-17)18-7-2-15(12-14(18)13-20(23)36)24(28,25(29,30)31)26(32,33)34/h2-7,12,19-20H,8-11,13H2,1H3/t19-,20?,23?/m0/s1 SLLNCMQNYXQVBT-UDTLNKQYSA-N 382837 US10273259, Example 548::US10711020, Example 548 Nuclear receptor ROR-gamma [262-507] 336 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382837 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382837&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678815 404852173 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931459 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CCC2(C1Cc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H25F8NO5S/c29-19-6-8-20(9-7-19)43(41,42)25-11-12-37(23(38)15-1-3-16(4-2-15)24(39)40)22(25)14-17-13-18(5-10-21(17)25)26(30,27(31,32)33)28(34,35)36/h5-10,13,15-16,22H,1-4,11-12,14H2,(H,39,40)/t15-,16-,22?,25? VALNASKGFRMDLH-QAXNPQHNSA-N 382838 US10273259, Example 549::US10273259, Example 553::US10711020, Example 553 Nuclear receptor ROR-gamma [262-507] 7576 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382838 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382838&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678650 404852174 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931460 C[C@@]1(CC[C@@H](CC1)C(O)=O)C(=O)N1CCC2(C1Cc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C29H27F8NO5S/c1-25(10-8-16(9-11-25)23(39)40)24(41)38-13-12-26(44(42,43)20-5-3-19(30)4-6-20)21-7-2-18(14-17(21)15-22(26)38)27(31,28(32,33)34)29(35,36)37/h2-7,14,16,22H,8-13,15H2,1H3,(H,39,40)/t16-,22?,25-,26? CPIJEWHFOPRYSI-FVSSTLBOSA-N 382839 US10273259, Example 550::US10711020, Example 550 Nuclear receptor ROR-gamma [262-507] 178 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382839 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382839&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679041 404852175 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931461 OC(=O)C12CCC(CC1)(CC2)C(=O)N1CCC2(C1Cc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C30H27F8NO5S/c31-19-2-4-20(5-3-19)45(43,44)27-13-14-39(23(40)25-7-10-26(11-8-25,12-9-25)24(41)42)22(27)16-17-15-18(1-6-21(17)27)28(32,29(33,34)35)30(36,37)38/h1-6,15,22H,7-14,16H2,(H,41,42) WRSSACMQTFMXGA-UHFFFAOYSA-N 382840 US10273259, Example 551::US10711020, Example 551 Nuclear receptor ROR-gamma [262-507] 166 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382840 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382840&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679034 404852176 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931462 OC(=O)[C@H]1CC[C@@](F)(CC1)C(=O)N1CCC2(C1Cc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H24F9NO5S/c29-18-2-4-19(5-3-18)44(42,43)25-11-12-38(23(41)24(30)9-7-15(8-10-24)22(39)40)21(25)14-16-13-17(1-6-20(16)25)26(31,27(32,33)34)28(35,36)37/h1-6,13,15,21H,7-12,14H2,(H,39,40)/t15-,21?,24+,25? RDEAWAIHQGSACB-DNNXONSASA-N 382841 US10273259, Example 552::US10711020, Example 552 Nuclear receptor ROR-gamma [262-507] 42.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382841 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382841&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678714 404852177 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931463 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CCC2(C1Cc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H25F8NO5S/c29-19-6-8-20(9-7-19)43(41,42)25-11-12-37(23(38)15-1-3-16(4-2-15)24(39)40)22(25)14-17-13-18(5-10-21(17)25)26(30,27(31,32)33)28(34,35)36/h5-10,13,15-16,22H,1-4,11-12,14H2,(H,39,40)/t15-,16-,22?,25? VALNASKGFRMDLH-QAXNPQHNSA-N 382838 US10273259, Example 549::US10273259, Example 553::US10711020, Example 553 Nuclear receptor ROR-gamma [262-507] 76.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382838 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382838&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678650 404852174 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931464 OC(=O)c1ccc(cc1)C(=O)N1CCC2(C1Cc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H19F8NO5S/c29-19-6-8-20(9-7-19)43(41,42)25-11-12-37(23(38)15-1-3-16(4-2-15)24(39)40)22(25)14-17-13-18(5-10-21(17)25)26(30,27(31,32)33)28(34,35)36/h1-10,13,22H,11-12,14H2,(H,39,40) TZPLVYMZLXMNQQ-UHFFFAOYSA-N 382843 US10273259, Example 554::US10711020, Example 554 Nuclear receptor ROR-gamma [262-507] 168 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382843 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382843&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678512 404852178 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931465 OC(=O)c1cccc(c1)C(=O)N1CCC2(C1Cc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H19F8NO5S/c29-19-5-7-20(8-6-19)43(41,42)25-10-11-37(23(38)15-2-1-3-16(12-15)24(39)40)22(25)14-17-13-18(4-9-21(17)25)26(30,27(31,32)33)28(34,35)36/h1-9,12-13,22H,10-11,14H2,(H,39,40) RSUAUWSZMQWICK-UHFFFAOYSA-N 382844 US10273259, Example 555::US10711020, Example 555 Nuclear receptor ROR-gamma [262-507] 595 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382844 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382844&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679196 404852179 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931466 OC(=O)[C@H]1CC[C@@](O)(CC1)C(=O)N1CCC2(C1Cc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H25F8NO6S/c29-18-2-4-19(5-3-18)44(42,43)25-11-12-37(23(40)24(41)9-7-15(8-10-24)22(38)39)21(25)14-16-13-17(1-6-20(16)25)26(30,27(31,32)33)28(34,35)36/h1-6,13,15,21,41H,7-12,14H2,(H,38,39)/t15-,21?,24+,25? ADHKWPQXUQOMGM-DNNXONSASA-N 382845 US10273259, Example 556::US10711020, Example 556 Nuclear receptor ROR-gamma [262-507] 86.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382845 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382845&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679046 404852180 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931467 COc1ccc(cc1)S(=O)(=O)C12CCN(C1Cc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)[C@@]1(O)CC[C@@H](CC1)C(O)=O InChI=1S/C29H28F7NO7S/c1-44-19-3-5-20(6-4-19)45(42,43)26-12-13-37(24(40)25(41)10-8-16(9-11-25)23(38)39)22(26)15-17-14-18(2-7-21(17)26)27(30,28(31,32)33)29(34,35)36/h2-7,14,16,22,41H,8-13,15H2,1H3,(H,38,39)/t16-,22?,25+,26? XJLNWPBBVORJRT-VXBFRIGJSA-N 382846 US10273259, Example 557::US10711020, Example 557 Nuclear receptor ROR-gamma [262-507] 128 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382846 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382846&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678966 404852181 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931468 OC(=O)C1CCCC(C1)C(=O)N1CCC2(C1Cc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H25F8NO5S/c29-19-5-7-20(8-6-19)43(41,42)25-10-11-37(23(38)15-2-1-3-16(12-15)24(39)40)22(25)14-17-13-18(4-9-21(17)25)26(30,27(31,32)33)28(34,35)36/h4-9,13,15-16,22H,1-3,10-12,14H2,(H,39,40) JJYPRJNCBPLVBA-UHFFFAOYSA-N 382847 US10273259, Example 558::US10711020, Example 558 Nuclear receptor ROR-gamma [262-507] 7982 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382847 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382847&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679120 404852182 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931469 OC(=O)C1CC2(C1)CC(C2)C(=O)N1CCC2(C1Cc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C29H25F8NO5S/c30-19-2-4-20(5-3-19)44(42,43)26-7-8-38(23(39)16-11-25(12-16)13-17(14-25)24(40)41)22(26)10-15-9-18(1-6-21(15)26)27(31,28(32,33)34)29(35,36)37/h1-6,9,16-17,22H,7-8,10-14H2,(H,40,41) VDNKHLCSDNEVRB-UHFFFAOYSA-N 382848 US10273259, Example 559::US10711020, Example 560 Nuclear receptor ROR-gamma [262-507] 1006 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382848 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382848&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678713 404852183 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931470 OC(=O)C1CC2(C1)CC(C2)C(=O)N1CCC2(C1Cc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C29H25F8NO5S/c30-19-2-4-20(5-3-19)44(42,43)26-7-8-38(23(39)16-11-25(12-16)13-17(14-25)24(40)41)22(26)10-15-9-18(1-6-21(15)26)27(31,28(32,33)34)29(35,36)37/h1-6,9,16-17,22H,7-8,10-14H2,(H,40,41) VDNKHLCSDNEVRB-UHFFFAOYSA-N 382848 US10273259, Example 559::US10711020, Example 560 Nuclear receptor ROR-gamma [262-507] 82.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382848 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382848&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678713 404852183 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931471 CC1(C)C2N(CCC2(c2ccc(cc12)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1)C(=O)[C@@]1(F)CC[C@@H](CC1)C(O)=O InChI=1S/C30H28F9NO5S/c1-25(2)21-15-17(28(33,29(34,35)36)30(37,38)39)3-8-20(21)27(46(44,45)19-6-4-18(31)5-7-19)13-14-40(23(25)27)24(43)26(32)11-9-16(10-12-26)22(41)42/h3-8,15-16,23H,9-14H2,1-2H3,(H,41,42)/t16-,23?,26+,27? XKICQBGVVZTRCV-ANAVBAIVSA-N 382850 US10273259, Example 561::US10711020, Example 561 Nuclear receptor ROR-gamma [262-507] 110 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382850 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382850&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679007 404852185 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931472 CC1(C)C2N(CCC2(c2ccc(cc12)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1)C(=O)C1CCS(=O)(=O)CC1 InChI=1S/C28H27F8NO5S2/c1-24(2)21-15-17(26(30,27(31,32)33)28(34,35)36)3-8-20(21)25(44(41,42)19-6-4-18(29)5-7-19)11-12-37(23(24)25)22(38)16-9-13-43(39,40)14-10-16/h3-8,15-16,23H,9-14H2,1-2H3 GRAVAHPUFHJPGH-UHFFFAOYSA-N 382851 US10273259, Example 562::US10711020, Example 562 Nuclear receptor ROR-gamma [262-507] 224 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382851 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382851&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679216 404852186 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931473 Fc1ccc(cc1)S(=O)(=O)C12CCN(C1Cc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)Cc1ccccc1C#N InChI=1S/C29H20F8N2O3S/c30-21-6-8-22(9-7-21)43(41,42)26-11-12-39(25(40)15-17-3-1-2-4-18(17)16-38)24(26)14-19-13-20(5-10-23(19)26)27(31,28(32,33)34)29(35,36)37/h1-10,13,24H,11-12,14-15H2 AJCXGQPAQMDLGM-UHFFFAOYSA-N 382852 US10273259, Example 563::US10711020, Example 563 Nuclear receptor ROR-gamma [262-507] 1935 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382852 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382852&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679227 404852187 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931474 CCNS(=O)(=O)CCC(=O)N1CCC2(C1Cc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C25H24F8N2O5S2/c1-2-34-41(37,38)12-9-21(36)35-11-10-22(42(39,40)18-6-4-17(26)5-7-18)19-8-3-16(13-15(19)14-20(22)35)23(27,24(28,29)30)25(31,32)33/h3-8,13,20,34H,2,9-12,14H2,1H3 FVNMJXGMWNHCBH-UHFFFAOYSA-N 382853 US10273259, Example 564::US10711020, Example 564 Nuclear receptor ROR-gamma [262-507] 275 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382853 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382853&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679059 404852188 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931475 CC(Nc1ccc(cc1)C#N)C(=O)N1CCC2(C1Cc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C30H23F8N3O3S/c1-17(40-22-7-2-18(16-39)3-8-22)26(42)41-13-12-27(45(43,44)23-9-5-21(31)6-10-23)24-11-4-20(14-19(24)15-25(27)41)28(32,29(33,34)35)30(36,37)38/h2-11,14,17,25,40H,12-13,15H2,1H3 URPAEKJNTHENFO-UHFFFAOYSA-N 382854 US10273259, Example 565::US10273259, Example 566::US10711020, Example 566 Nuclear receptor ROR-gamma [262-507] 123 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382854 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382854&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678722 404852189 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931476 CC(Nc1ccc(cc1)C#N)C(=O)N1CCC2(C1Cc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C30H23F8N3O3S/c1-17(40-22-7-2-18(16-39)3-8-22)26(42)41-13-12-27(45(43,44)23-9-5-21(31)6-10-23)24-11-4-20(14-19(24)15-25(27)41)28(32,29(33,34)35)30(36,37)38/h2-11,14,17,25,40H,12-13,15H2,1H3 URPAEKJNTHENFO-UHFFFAOYSA-N 382854 US10273259, Example 565::US10273259, Example 566::US10711020, Example 566 Nuclear receptor ROR-gamma [262-507] 643 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382854 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382854&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678722 404852189 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931477 Cc1cc(cc(C)n1)C(=O)N1CCC2(C1Cc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H22F8N2O3S/c1-15-11-18(12-16(2)37-15)24(39)38-10-9-25(42(40,41)21-6-4-20(29)5-7-21)22-8-3-19(13-17(22)14-23(25)38)26(30,27(31,32)33)28(34,35)36/h3-8,11-13,23H,9-10,14H2,1-2H3 VBVQNSWSDZMDLS-UHFFFAOYSA-N 382856 US10273259, Example 567::US10711020, Example 567 Nuclear receptor ROR-gamma [262-507] 444 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382856 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382856&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678831 404852190 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931478 Fc1ccc(cc1)S(=O)(=O)C12CCN(C1Cc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1CC1c1ccccc1 InChI=1S/C30H23F8NO3S/c31-20-7-9-21(10-8-20)43(41,42)27-12-13-39(26(40)23-16-22(23)17-4-2-1-3-5-17)25(27)15-18-14-19(6-11-24(18)27)28(32,29(33,34)35)30(36,37)38/h1-11,14,22-23,25H,12-13,15-16H2 SMTZSATXSUPHTC-UHFFFAOYSA-N 382857 US10273259, Example 568::US10273259, Example 569::US10711020, Example 569 Nuclear receptor ROR-gamma [262-507] 489 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382857 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382857&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679045 404852191 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931479 Fc1ccc(cc1)S(=O)(=O)C12CCN(C1Cc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1CC1c1ccccc1 InChI=1S/C30H23F8NO3S/c31-20-7-9-21(10-8-20)43(41,42)27-12-13-39(26(40)23-16-22(23)17-4-2-1-3-5-17)25(27)15-18-14-19(6-11-24(18)27)28(32,29(33,34)35)30(36,37)38/h1-11,14,22-23,25H,12-13,15-16H2 SMTZSATXSUPHTC-UHFFFAOYSA-N 382857 US10273259, Example 568::US10273259, Example 569::US10711020, Example 569 Nuclear receptor ROR-gamma [262-507] 47.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382857 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382857&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679045 404852191 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931480 CC(=O)Nc1cccc(c1)C(=O)N1CCC2(C1Cc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C29H22F8N2O4S/c1-16(40)38-21-4-2-3-17(14-21)25(41)39-12-11-26(44(42,43)22-8-6-20(30)7-9-22)23-10-5-19(13-18(23)15-24(26)39)27(31,28(32,33)34)29(35,36)37/h2-10,13-14,24H,11-12,15H2,1H3,(H,38,40) CDIINHLMLXPNHA-UHFFFAOYSA-N 382859 US10273259, Example 570::US10711020, Example 570 Nuclear receptor ROR-gamma [262-507] 596 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382859 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382859&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678822 404852192 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931481 Fc1ccc(cc1)S(=O)(=O)C12CCN(C1Cc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1CNC(=O)c2ccccc12 InChI=1S/C30H22F8N2O4S/c31-18-6-8-19(9-7-18)45(43,44)27-11-12-40(26(42)22-15-39-25(41)21-4-2-1-3-20(21)22)24(27)14-16-13-17(5-10-23(16)27)28(32,29(33,34)35)30(36,37)38/h1-10,13,22,24H,11-12,14-15H2,(H,39,41) UFCRCOBINSFZRO-UHFFFAOYSA-N 382860 US10273259, Example 571::US10273259, Example 572::US10711020, Example 572 Nuclear receptor ROR-gamma [262-507] 1352 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382860 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382860&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678726 404852193 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931482 Fc1ccc(cc1)S(=O)(=O)C12CCN(C1Cc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1CNC(=O)c2ccccc12 InChI=1S/C30H22F8N2O4S/c31-18-6-8-19(9-7-18)45(43,44)27-11-12-40(26(42)22-15-39-25(41)21-4-2-1-3-20(21)22)24(27)14-16-13-17(5-10-23(16)27)28(32,29(33,34)35)30(36,37)38/h1-10,13,22,24H,11-12,14-15H2,(H,39,41) UFCRCOBINSFZRO-UHFFFAOYSA-N 382860 US10273259, Example 571::US10273259, Example 572::US10711020, Example 572 Nuclear receptor ROR-gamma [262-507] 5920 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382860 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382860&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678726 404852193 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931483 Fc1ccc(cc1)S(=O)(=O)C12CCN(C1Cc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)c1ccc2OCC(=O)Nc2c1 InChI=1S/C29H20F8N2O5S/c30-18-3-5-19(6-4-18)45(42,43)26-9-10-39(25(41)15-1-8-22-21(12-15)38-24(40)14-44-22)23(26)13-16-11-17(2-7-20(16)26)27(31,28(32,33)34)29(35,36)37/h1-8,11-12,23H,9-10,13-14H2,(H,38,40) BECOAWDHXQABCM-UHFFFAOYSA-N 382862 US10273259, Example 573::US10711020, Example 573 Nuclear receptor ROR-gamma [262-507] 1393 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382862 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382862&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679237 404852194 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931484 Fc1ccc(cc1)S(=O)(=O)C12CCN(C1Cc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)c1cccc(c1)-c1ncn[nH]1 382863 US10273259, Example 574::US10711020, Example 574 Nuclear receptor ROR-gamma [262-507] 384 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382863 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382863&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678723 404852195 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931485 Fc1ccc(cc1)S(=O)(=O)C12CCN(C1Cc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)c1cc(F)cc(c1)C#N InChI=1S/C28H17F9N2O3S/c29-19-2-4-21(5-3-19)43(41,42)25-7-8-39(24(40)17-9-15(14-38)10-20(30)12-17)23(25)13-16-11-18(1-6-22(16)25)26(31,27(32,33)34)28(35,36)37/h1-6,9-12,23H,7-8,13H2 CXDLLHCOPZQYBX-UHFFFAOYSA-N 382864 US10273259, Example 575::US10711020, Example 575 Nuclear receptor ROR-gamma [262-507] 416 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382864 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382864&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679212 404852196 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931486 Fc1ccc(cc1)S(=O)(=O)C12CCN(C1Cc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)c1cc2ccncc2[nH]1 382865 US10273259, Example 576::US10711020, Example 576 Nuclear receptor ROR-gamma [262-507] 273 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382865 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382865&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679197 404852197 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931487 OC12CCCC(CCC1)(C2)C(=O)N1CCC2(C1Cc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C30H29F8NO4S/c31-20-4-6-21(7-5-20)44(42,43)27-13-14-39(24(40)25-9-1-11-26(41,17-25)12-2-10-25)23(27)16-18-15-19(3-8-22(18)27)28(32,29(33,34)35)30(36,37)38/h3-8,15,23,41H,1-2,9-14,16-17H2 RLAOLSNYIGONHT-UHFFFAOYSA-N 382866 US10273259, Example 577::US10711020, Example 577 Nuclear receptor ROR-gamma [262-507] 11.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382866 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382866&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678727 404852198 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931488 CN(C(C)=O)c1ccc(cc1)C(=O)N1CCC2(C1Cc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C30H24F8N2O4S/c1-17(41)39(2)22-8-3-18(4-9-22)26(42)40-14-13-27(45(43,44)23-10-6-21(31)7-11-23)24-12-5-20(15-19(24)16-25(27)40)28(32,29(33,34)35)30(36,37)38/h3-12,15,25H,13-14,16H2,1-2H3 OVSFXGUMHVFWRA-UHFFFAOYSA-N 382867 US10273259, Example 578::US10711020, Example 578 Nuclear receptor ROR-gamma [262-507] 4563 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382867 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382867&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678922 404852199 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931489 CC1(C)C2CN(CC2(c2ccc(cc12)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1)C(=O)C1CCS(=O)(=O)CC1 InChI=1S/C28H27F8NO5S2/c1-24(2)21-13-17(26(30,27(31,32)33)28(34,35)36)3-8-20(21)25(44(41,42)19-6-4-18(29)5-7-19)15-37(14-22(24)25)23(38)16-9-11-43(39,40)12-10-16/h3-8,13,16,22H,9-12,14-15H2,1-2H3 QHHAKOGJKXHIIF-UHFFFAOYSA-N 382868 US10273259, Example 579::US10273259, Example 580::US10711020, Example 580 Nuclear receptor ROR-gamma [262-507] 108 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382868 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382868&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678806 404852200 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931490 CC1(C)C2CN(CC2(c2ccc(cc12)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1)C(=O)C1CCS(=O)(=O)CC1 InChI=1S/C28H27F8NO5S2/c1-24(2)21-13-17(26(30,27(31,32)33)28(34,35)36)3-8-20(21)25(44(41,42)19-6-4-18(29)5-7-19)15-37(14-22(24)25)23(38)16-9-11-43(39,40)12-10-16/h3-8,13,16,22H,9-12,14-15H2,1-2H3 QHHAKOGJKXHIIF-UHFFFAOYSA-N 382868 US10273259, Example 579::US10273259, Example 580::US10711020, Example 580 Nuclear receptor ROR-gamma [262-507] 1518 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382868 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382868&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678806 404852200 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931491 CC1(C)C2CN(CC2(c2ccc(cc12)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1)C(=O)[C@H]1CC[C@@H](CC1)C(O)=O InChI=1S/C30H29F8NO5S/c1-26(2)22-13-18(28(32,29(33,34)35)30(36,37)38)7-12-21(22)27(45(43,44)20-10-8-19(31)9-11-20)15-39(14-23(26)27)24(40)16-3-5-17(6-4-16)25(41)42/h7-13,16-17,23H,3-6,14-15H2,1-2H3,(H,41,42)/t16-,17-,23?,27? HCAKNKPOVRTLII-VMGIOJFMSA-N 382870 US10273259, Example 581::US10273259, Example 582::US10711020, Example 582 Nuclear receptor ROR-gamma [262-507] 98.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382870 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382870&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679063 404852201 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931492 CC1(C)C2CN(CC2(c2ccc(cc12)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1)C(=O)[C@H]1CC[C@@H](CC1)C(O)=O InChI=1S/C30H29F8NO5S/c1-26(2)22-13-18(28(32,29(33,34)35)30(36,37)38)7-12-21(22)27(45(43,44)20-10-8-19(31)9-11-20)15-39(14-23(26)27)24(40)16-3-5-17(6-4-16)25(41)42/h7-13,16-17,23H,3-6,14-15H2,1-2H3,(H,41,42)/t16-,17-,23?,27? HCAKNKPOVRTLII-VMGIOJFMSA-N 382870 US10273259, Example 581::US10273259, Example 582::US10711020, Example 582 Nuclear receptor ROR-gamma [262-507] 6891 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382870 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382870&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679063 404852201 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931493 OC(=O)[C@H]1CC[C@@](F)(CC1)C(=O)N1CC2Oc3cc(ccc3C2(C1)S(=O)(=O)c1ccc(F)cc1)C(F)(C(F)(F)F)C(F)(F)F InChI=1S/C27H22F9NO6S/c28-16-2-4-17(5-3-16)44(41,42)24-13-37(22(40)23(29)9-7-14(8-10-23)21(38)39)12-20(24)43-19-11-15(1-6-18(19)24)25(30,26(31,32)33)27(34,35)36/h1-6,11,14,20H,7-10,12-13H2,(H,38,39)/t14-,20?,23+,24? OOWQLVRMCALMNH-ZCVBTQTPSA-N 382872 US10273259, Example 583::US10273259, Example 584::US10711020, Example 584 Nuclear receptor ROR-gamma [262-507] 2798 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382872 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382872&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679215 404852202 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931494 OC(=O)[C@H]1CC[C@@](F)(CC1)C(=O)N1CC2Oc3cc(ccc3C2(C1)S(=O)(=O)c1ccc(F)cc1)C(F)(C(F)(F)F)C(F)(F)F InChI=1S/C27H22F9NO6S/c28-16-2-4-17(5-3-16)44(41,42)24-13-37(22(40)23(29)9-7-14(8-10-23)21(38)39)12-20(24)43-19-11-15(1-6-18(19)24)25(30,26(31,32)33)27(34,35)36/h1-6,11,14,20H,7-10,12-13H2,(H,38,39)/t14-,20?,23+,24? OOWQLVRMCALMNH-ZCVBTQTPSA-N 382872 US10273259, Example 583::US10273259, Example 584::US10711020, Example 584 Nuclear receptor ROR-gamma [262-507] 13826 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382872 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382872&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679215 404852202 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931495 Fc1ccc(cc1)S(=O)(=O)C12CN(CC1Oc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1CCS(=O)(=O)CC1 InChI=1S/C25H21F8NO6S2/c26-16-2-4-17(5-3-16)42(38,39)22-13-34(21(35)14-7-9-41(36,37)10-8-14)12-20(22)40-19-11-15(1-6-18(19)22)23(27,24(28,29)30)25(31,32)33/h1-6,11,14,20H,7-10,12-13H2 KSEUAZYMJVUHQG-UHFFFAOYSA-N 382874 US10273259, Example 585::US10711020, Example 585 Nuclear receptor ROR-gamma [262-507] 8537 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382874 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382874&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679186 404852203 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931496 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CC2CCc3cc(ccc3C2(C1)S(=O)(=O)c1ccc(F)cc1)C(F)(C(F)(F)F)C(F)(F)F InChI=1S/C29H27F8NO5S/c30-21-8-10-22(11-9-21)44(42,43)26-15-38(24(39)16-1-3-17(4-2-16)25(40)41)14-20(26)6-5-18-13-19(7-12-23(18)26)27(31,28(32,33)34)29(35,36)37/h7-13,16-17,20H,1-6,14-15H2,(H,40,41)/t16-,17-,20?,26? RIDQGXYSIJPZIM-OPLQCYDDSA-N 382875 US10273259, Example 586::US10711020, Example 620 Nuclear receptor ROR-gamma [262-507] 79.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382875 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382875&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678656 404852204 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931497 OC(=O)C12CCC(CC1)(CC2)C(=O)N1CC2CCc3cc(ccc3C2(C1)S(=O)(=O)c1ccc(F)cc1)C(F)(C(F)(F)F)C(F)(F)F InChI=1S/C31H29F8NO5S/c32-21-4-6-22(7-5-21)46(44,45)28-17-40(24(41)26-9-12-27(13-10-26,14-11-26)25(42)43)16-20(28)2-1-18-15-19(3-8-23(18)28)29(33,30(34,35)36)31(37,38)39/h3-8,15,20H,1-2,9-14,16-17H2,(H,42,43) RLGGHTPFORLLGC-UHFFFAOYSA-N 382876 US10273259, Example 587::US10273259, Example 621::US10711020, Example 621 Nuclear receptor ROR-gamma [262-507] 158 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382876 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382876&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679213 404852205 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931498 OC(=O)C1CCCC(C1)C(=O)N1CC2CCc3cc(ccc3C2(C1)S(=O)(=O)c1ccc(F)cc1)C(F)(C(F)(F)F)C(F)(F)F InChI=1S/C29H27F8NO5S/c30-21-7-9-22(10-8-21)44(42,43)26-15-38(24(39)17-2-1-3-18(12-17)25(40)41)14-20(26)5-4-16-13-19(6-11-23(16)26)27(31,28(32,33)34)29(35,36)37/h6-11,13,17-18,20H,1-5,12,14-15H2,(H,40,41) RUUOWBOOOXSWOU-UHFFFAOYSA-N 382877 US10273259, Example 588::US10273259, Example 589::US10711020, Example 589 Nuclear receptor ROR-gamma [262-507] 894 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382877 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382877&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 132123826 404852206 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931499 OC(=O)C1CCCC(C1)C(=O)N1CC2CCc3cc(ccc3C2(C1)S(=O)(=O)c1ccc(F)cc1)C(F)(C(F)(F)F)C(F)(F)F InChI=1S/C29H27F8NO5S/c30-21-7-9-22(10-8-21)44(42,43)26-15-38(24(39)17-2-1-3-18(12-17)25(40)41)14-20(26)5-4-16-13-19(6-11-23(16)26)27(31,28(32,33)34)29(35,36)37/h6-11,13,17-18,20H,1-5,12,14-15H2,(H,40,41) RUUOWBOOOXSWOU-UHFFFAOYSA-N 382877 US10273259, Example 588::US10273259, Example 589::US10711020, Example 589 Nuclear receptor ROR-gamma [262-507] 771 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382877 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382877&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 132123826 404852206 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931500 Fc1ccc(cc1)S(=O)(=O)C12CN(CC1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1CCS(=O)(=O)CC1 InChI=1S/C27H25F8NO5S2/c28-20-4-6-21(7-5-20)43(40,41)24-15-36(23(37)16-9-11-42(38,39)12-10-16)14-19(24)2-1-17-13-18(3-8-22(17)24)25(29,26(30,31)32)27(33,34)35/h3-8,13,16,19H,1-2,9-12,14-15H2 BYJQBROKHHUEJL-UHFFFAOYSA-N 382879 US10273259, Example 590::US10711020, Example 590 Nuclear receptor ROR-gamma [262-507] 64.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382879 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382879&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679070 404852207 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931501 CC(C)(O)CC(=O)N1CC2CCc3cc(ccc3C2(C1)S(=O)(=O)c1ccc(F)cc1)C(F)(C(F)(F)F)C(F)(F)F InChI=1S/C26H25F8NO4S/c1-22(2,37)12-21(36)35-13-17-4-3-15-11-16(24(28,25(29,30)31)26(32,33)34)5-10-20(15)23(17,14-35)40(38,39)19-8-6-18(27)7-9-19/h5-11,17,37H,3-4,12-14H2,1-2H3 YJQDWWAPVDZSFU-UHFFFAOYSA-N 382880 US10273259, Example 591::US10711020, Example 591 Nuclear receptor ROR-gamma [262-507] 202 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382880&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678715 404852208 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931502 OC(=O)c1cc(on1)C(=O)N1CC2CCc3cc(ccc3C2(C1)S(=O)(=O)c1ccc(F)cc1)C(F)(C(F)(F)F)C(F)(F)F InChI=1S/C26H18F8N2O6S/c27-16-4-6-17(7-5-16)43(40,41)23-12-36(21(37)20-10-19(22(38)39)35-42-20)11-15(23)2-1-13-9-14(3-8-18(13)23)24(28,25(29,30)31)26(32,33)34/h3-10,15H,1-2,11-12H2,(H,38,39) ZHDBIKJGYVNLPR-UHFFFAOYSA-N 382881 US10273259, Example 592::US10711020, Example 592 Nuclear receptor ROR-gamma [262-507] 145 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382881 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382881&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678829 404852209 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931503 OC(=O)c1cnc(cn1)C(=O)N1CC2CCc3cc(ccc3C2(C1)S(=O)(=O)c1ccc(F)cc1)C(F)(C(F)(F)F)C(F)(F)F InChI=1S/C27H19F8N3O5S/c28-17-4-6-18(7-5-17)44(42,43)24-13-38(22(39)20-10-37-21(11-36-20)23(40)41)12-16(24)2-1-14-9-15(3-8-19(14)24)25(29,26(30,31)32)27(33,34)35/h3-11,16H,1-2,12-13H2,(H,40,41) CKKIKJALWNCAKN-UHFFFAOYSA-N 382882 US10273259, Example 593::US10711020, Example 593 Nuclear receptor ROR-gamma [262-507] 130 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382882 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382882&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679090 404852210 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931504 OC(=O)c1c[nH]c(c1)C(=O)N1CC2CCc3cc(ccc3C2(C1)S(=O)(=O)c1ccc(F)cc1)C(F)(C(F)(F)F)C(F)(F)F 382883 US10273259, Example 594::US10711020, Example 594 Nuclear receptor ROR-gamma [262-507] 245 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382883 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382883&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679042 404852211 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931505 OC(=O)c1cc([nH]n1)C(=O)N1CC2CCc3cc(ccc3C2(C1)S(=O)(=O)c1ccc(F)cc1)C(F)(C(F)(F)F)C(F)(F)F 382884 US10273259, Example 595::US10711020, Example 595 Nuclear receptor ROR-gamma [262-507] 825 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382884 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382884&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679220 404852212 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931506 Fc1ccc(cc1)S(=O)(=O)C12CN(CC1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)CC1CC(=O)NC(=O)C1 InChI=1S/C28H24F8N2O5S/c29-19-4-6-20(7-5-19)44(42,43)25-14-38(24(41)11-15-9-22(39)37-23(40)10-15)13-18(25)2-1-16-12-17(3-8-21(16)25)26(30,27(31,32)33)28(34,35)36/h3-8,12,15,18H,1-2,9-11,13-14H2,(H,37,39,40) RATMPLBUFOJCAA-UHFFFAOYSA-N 382885 US10273259, Example 596::US10711020, Example 596 Nuclear receptor ROR-gamma [262-507] 120 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382885 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382885&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679022 404852213 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931507 Fc1ccc(cc1)S(=O)(=O)C12CN(CC1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)c1cncs1 InChI=1S/C25H18F8N2O3S2/c26-17-4-6-18(7-5-17)40(37,38)22-12-35(21(36)20-10-34-13-39-20)11-16(22)2-1-14-9-15(3-8-19(14)22)23(27,24(28,29)30)25(31,32)33/h3-10,13,16H,1-2,11-12H2 BJMGBJGECLJTNN-UHFFFAOYSA-N 382886 US10273259, Example 597::US10711020, Example 597 Nuclear receptor ROR-gamma [262-507] 333 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382886 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382886&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678690 404852214 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931508 Fc1ccc(cc1)S(=O)(=O)C12CN(CC1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)c1cc(=O)cco1 InChI=1S/C27H19F8NO5S/c28-18-4-6-20(7-5-18)42(39,40)24-14-36(23(38)22-12-19(37)9-10-41-22)13-17(24)2-1-15-11-16(3-8-21(15)24)25(29,26(30,31)32)27(33,34)35/h3-12,17H,1-2,13-14H2 LQHMVONMQMTMHJ-UHFFFAOYSA-N 382887 US10273259, Example 598::US10711020, Example 598 Nuclear receptor ROR-gamma [262-507] 166 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382887 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382887&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679239 404852215 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931509 CCCCC(O)C(=O)N1CC2CCc3cc(ccc3C2(C1)S(=O)(=O)c1ccc(F)cc1)C(F)(C(F)(F)F)C(F)(F)F InChI=1S/C27H27F8NO4S/c1-2-3-4-22(37)23(38)36-14-18-6-5-16-13-17(25(29,26(30,31)32)27(33,34)35)7-12-21(16)24(18,15-36)41(39,40)20-10-8-19(28)9-11-20/h7-13,18,22,37H,2-6,14-15H2,1H3 SOSNWIWFFPVBQS-UHFFFAOYSA-N 382888 US10273259, Example 599::US10711020, Example 599 Nuclear receptor ROR-gamma [262-507] 311 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382888 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382888&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679211 404852216 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931510 OC(C1CCCCC1)C(=O)N1CC2CCc3cc(ccc3C2(C1)S(=O)(=O)c1ccc(F)cc1)C(F)(C(F)(F)F)C(F)(F)F InChI=1S/C29H29F8NO4S/c30-21-9-11-22(12-10-21)43(41,42)26-16-38(25(40)24(39)17-4-2-1-3-5-17)15-20(26)7-6-18-14-19(8-13-23(18)26)27(31,28(32,33)34)29(35,36)37/h8-14,17,20,24,39H,1-7,15-16H2 FIUZBQCEBITIEI-UHFFFAOYSA-N 453635 US10711020, Example 600 Nuclear receptor ROR-gamma [262-507] 197 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=453635 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=453635&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679222 440969524 C03491 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931511 Fc1ccc(cc1)S(=O)(=O)C12CN(CC1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)c1ccnnc1 InChI=1S/C26H19F8N3O3S/c27-19-4-6-20(7-5-19)41(39,40)23-14-37(22(38)16-9-10-35-36-12-16)13-18(23)2-1-15-11-17(3-8-21(15)23)24(28,25(29,30)31)26(32,33)34/h3-12,18H,1-2,13-14H2 CPMXAOUPPQMLSP-UHFFFAOYSA-N 382890 US10273259, Example 601::US10711020, Example 601 Nuclear receptor ROR-gamma [262-507] 231 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382890 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382890&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678724 404852218 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931512 Fc1ccc(cc1)S(=O)(=O)C12CN(CC1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)c1cc2cnccc2[nH]1 382891 US10273259, Example 602::US10711020, Example 602 Nuclear receptor ROR-gamma [262-507] 100.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382891 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382891&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679229 404852219 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931513 Fc1ccc(cc1)S(=O)(=O)C12CN(CC1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)c1coc2CCCC(=O)c12 InChI=1S/C30H23F8NO5S/c31-19-7-9-20(10-8-19)45(42,43)27-15-39(26(41)21-14-44-24-3-1-2-23(40)25(21)24)13-18(27)5-4-16-12-17(6-11-22(16)27)28(32,29(33,34)35)30(36,37)38/h6-12,14,18H,1-5,13,15H2 DLTFUPQIYFEYJW-UHFFFAOYSA-N 382892 US10273259, Example 603::US10711020, Example 603 Nuclear receptor ROR-gamma [262-507] 267 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382892 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382892&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679188 404852220 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931514 Oc1cc(on1)C(=O)N1CC2CCc3cc(ccc3C2(C1)S(=O)(=O)c1ccc(F)cc1)C(F)(C(F)(F)F)C(F)(F)F InChI=1S/C25H18F8N2O5S/c26-16-4-6-17(7-5-16)41(38,39)22-12-35(21(37)19-10-20(36)34-40-19)11-15(22)2-1-13-9-14(3-8-18(13)22)23(27,24(28,29)30)25(31,32)33/h3-10,15H,1-2,11-12H2,(H,34,36) DXGSXIOOHIZPQC-UHFFFAOYSA-N 382893 US10273259, Example 604::US10711020, Example 604 Nuclear receptor ROR-gamma [262-507] 319 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382893 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382893&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678843 404852221 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931515 Fc1ccc(cc1)S(=O)(=O)C12CN(CC1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)c1cnc[nH]1 382894 US10273259, Example 605::US10711020, Example 605 Nuclear receptor ROR-gamma [262-507] 397 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382894 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382894&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678827 404852222 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931516 Cn1nc2CCCCc2c1C(=O)N1CC2CCc3cc(ccc3C2(C1)S(=O)(=O)c1ccc(F)cc1)C(F)(C(F)(F)F)C(F)(F)F InChI=1S/C30H27F8N3O3S/c1-40-25(22-4-2-3-5-24(22)39-40)26(42)41-15-19-7-6-17-14-18(28(32,29(33,34)35)30(36,37)38)8-13-23(17)27(19,16-41)45(43,44)21-11-9-20(31)10-12-21/h8-14,19H,2-7,15-16H2,1H3 WKNSUEVQHBMKOU-UHFFFAOYSA-N 382895 US10273259, Example 606::US10711020, Example 606 Nuclear receptor ROR-gamma [262-507] 244 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382895 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382895&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679077 404852223 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931517 Fc1ccc(cc1)S(=O)(=O)C12CN(CC1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)c1c[nH]c2nccnc12 382896 US10273259, Example 607::US10711020, Example 607 Nuclear receptor ROR-gamma [262-507] 342 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382896 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382896&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679050 404852224 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931518 Fc1ccc(cc1)S(=O)(=O)C12CN(CC1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)Cc1ccc2ncccc2c1 InChI=1S/C32H24F8N2O3S/c33-24-7-9-25(10-8-24)46(44,45)29-18-42(28(43)15-19-3-12-27-21(14-19)2-1-13-41-27)17-23(29)5-4-20-16-22(6-11-26(20)29)30(34,31(35,36)37)32(38,39)40/h1-3,6-14,16,23H,4-5,15,17-18H2 VBHOROJAAXNQGZ-UHFFFAOYSA-N 382897 US10273259, Example 608::US10711020, Example 608 Nuclear receptor ROR-gamma [262-507] 286 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382897 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382897&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679025 404852225 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931519 Fc1ccc(cc1)S(=O)(=O)C12CN(CC1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)c1cnc(Cl)s1 InChI=1S/C25H17ClF8N2O3S2/c26-21-35-10-19(40-21)20(37)36-11-15-2-1-13-9-14(23(28,24(29,30)31)25(32,33)34)3-8-18(13)22(15,12-36)41(38,39)17-6-4-16(27)5-7-17/h3-10,15H,1-2,11-12H2 NNIIYHJSKSTVLX-UHFFFAOYSA-N 382898 US10273259, Example 609::US10711020, Example 609 Nuclear receptor ROR-gamma [262-507] 117 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382898 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382898&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679086 404852226 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931520 Fc1ccc(cc1)S(=O)(=O)C12CN(CC1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1=CCCC1 InChI=1S/C27H23F8NO3S/c28-20-8-10-21(11-9-20)40(38,39)24-15-36(23(37)16-3-1-2-4-16)14-19(24)6-5-17-13-18(7-12-22(17)24)25(29,26(30,31)32)27(33,34)35/h3,7-13,19H,1-2,4-6,14-15H2 DZUXOKIFEXTESF-UHFFFAOYSA-N 382899 US10273259, Example 610::US10711020, Example 610 Nuclear receptor ROR-gamma [262-507] 185 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382899 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382899&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678825 404852227 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931521 Fc1ccc(cc1)S(=O)(=O)C12CN(CC1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)c1cc[nH]n1 382900 US10273259, Example 611::US10711020, Example 611 Nuclear receptor ROR-gamma [262-507] 610 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382900 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382900&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679245 404852228 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931522 OCC(O)C(=O)N1CC2CCc3cc(ccc3C2(C1)S(=O)(=O)c1ccc(F)cc1)C(F)(C(F)(F)F)C(F)(F)F InChI=1S/C24H21F8NO5S/c25-16-4-6-17(7-5-16)39(37,38)21-12-33(20(36)19(35)11-34)10-15(21)2-1-13-9-14(3-8-18(13)21)22(26,23(27,28)29)24(30,31)32/h3-9,15,19,34-35H,1-2,10-12H2 JGCCPHHZLYNPHX-UHFFFAOYSA-N 382901 US10273259, Example 612::US10711020, Example 612 Nuclear receptor ROR-gamma [262-507] 360 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382901 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382901&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678824 404852229 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931523 Fc1ccc(cc1)S(=O)(=O)C12CN(CC1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)c1cnc(s1)C1OCCO1 InChI=1S/C28H22F8N2O5S2/c29-18-4-6-19(7-5-18)45(40,41)25-14-38(23(39)21-12-37-22(44-21)24-42-9-10-43-24)13-17(25)2-1-15-11-16(3-8-20(15)25)26(30,27(31,32)33)28(34,35)36/h3-8,11-12,17,24H,1-2,9-10,13-14H2 BVYLTFLDGZQHFJ-UHFFFAOYSA-N 382902 US10273259, Example 613::US10711020, Example 613 Nuclear receptor ROR-gamma [262-507] 660 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382902 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382902&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678849 404852230 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931524 Fc1ccc(cc1)S(=O)(=O)C12CN(CC1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)c1ccsc1 InChI=1S/C26H19F8NO3S2/c27-19-4-6-20(7-5-19)40(37,38)23-14-35(22(36)16-9-10-39-13-16)12-18(23)2-1-15-11-17(3-8-21(15)23)24(28,25(29,30)31)26(32,33)34/h3-11,13,18H,1-2,12,14H2 KLJOETHBXLRMBZ-UHFFFAOYSA-N 382903 US10273259, Example 614::US10711020, Example 614 Nuclear receptor ROR-gamma [262-507] 190 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382903 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382903&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679011 404852231 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931525 Fc1ccc(cc1)S(=O)(=O)C12CN(CC1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)c1ccns1 InChI=1S/C25H18F8N2O3S2/c26-17-4-6-18(7-5-17)40(37,38)22-13-35(21(36)20-9-10-34-39-20)12-16(22)2-1-14-11-15(3-8-19(14)22)23(27,24(28,29)30)25(31,32)33/h3-11,16H,1-2,12-13H2 LTOJHNPVNDICSX-UHFFFAOYSA-N 382904 US10273259, Example 615::US10711020, Example 615 Nuclear receptor ROR-gamma [262-507] 125 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382904 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382904&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678861 404852232 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931526 Fc1ccc(cc1)S(=O)(=O)C12CN(CC1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1Cc2cc(Cl)ccc2N1 InChI=1S/C30H23ClF8N2O3S/c31-20-4-10-24-17(12-20)13-25(40-24)26(42)41-14-19-2-1-16-11-18(28(33,29(34,35)36)30(37,38)39)3-9-23(16)27(19,15-41)45(43,44)22-7-5-21(32)6-8-22/h3-12,19,25,40H,1-2,13-15H2 CKFGGUJEUQVRNT-UHFFFAOYSA-N 382905 US10273259, Example 616::US10711020, Example 616 Nuclear receptor ROR-gamma [262-507] 1364 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382905 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382905&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679073 404852233 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931527 Fc1ccc(cc1)S(=O)(=O)C12CN(CC1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)c1ccno1 InChI=1S/C25H18F8N2O4S/c26-17-4-6-18(7-5-17)40(37,38)22-13-35(21(36)20-9-10-34-39-20)12-16(22)2-1-14-11-15(3-8-19(14)22)23(27,24(28,29)30)25(31,32)33/h3-11,16H,1-2,12-13H2 QOJXPPRKWRSKJP-UHFFFAOYSA-N 382906 US10273259, Example 617::US10711020, Example 617 Nuclear receptor ROR-gamma [262-507] 192 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382906 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382906&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678869 404852234 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931528 Fc1ccc(cc1)S(=O)(=O)C12CN(CC1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)c1ccon1 InChI=1S/C25H18F8N2O4S/c26-17-4-6-18(7-5-17)40(37,38)22-13-35(21(36)20-9-10-39-34-20)12-16(22)2-1-14-11-15(3-8-19(14)22)23(27,24(28,29)30)25(31,32)33/h3-11,16H,1-2,12-13H2 AEYQRMPASXTBKI-UHFFFAOYSA-N 382907 US10273259, Example 618::US10711020, Example 618 Nuclear receptor ROR-gamma [262-507] 392 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382907 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382907&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679091 404852235 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931529 Fc1ccc(cc1)S(=O)(=O)C12CN(CC1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1(CC1)C#N InChI=1S/C26H20F8N2O3S/c27-18-4-6-19(7-5-18)40(38,39)23-14-36(21(37)22(13-35)9-10-22)12-17(23)2-1-15-11-16(3-8-20(15)23)24(28,25(29,30)31)26(32,33)34/h3-8,11,17H,1-2,9-10,12,14H2 FPABLRXQWBFMDY-UHFFFAOYSA-N 382908 US10273259, Example 619::US10711020, Example 619 Nuclear receptor ROR-gamma [262-507] 271 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382908 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382908&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678744 404852236 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931530 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CC2CCc3cc(ccc3C2(C1)S(=O)(=O)c1ccc(F)cc1)C(F)(C(F)(F)F)C(F)(F)F InChI=1S/C29H27F8NO5S/c30-21-8-10-22(11-9-21)44(42,43)26-15-38(24(39)16-1-3-17(4-2-16)25(40)41)14-20(26)6-5-18-13-19(7-12-23(18)26)27(31,28(32,33)34)29(35,36)37/h7-13,16-17,20H,1-6,14-15H2,(H,40,41)/t16-,17-,20?,26? RIDQGXYSIJPZIM-OPLQCYDDSA-N 382875 US10273259, Example 586::US10711020, Example 620 Nuclear receptor ROR-gamma [262-507] 493 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382875 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382875&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678656 404852204 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931531 OC(=O)C12CCC(CC1)(CC2)C(=O)N1CC2CCc3cc(ccc3C2(C1)S(=O)(=O)c1ccc(F)cc1)C(F)(C(F)(F)F)C(F)(F)F InChI=1S/C31H29F8NO5S/c32-21-4-6-22(7-5-21)46(44,45)28-17-40(24(41)26-9-12-27(13-10-26,14-11-26)25(42)43)16-20(28)2-1-18-15-19(3-8-23(18)28)29(33,30(34,35)36)31(37,38)39/h3-8,15,20H,1-2,9-14,16-17H2,(H,42,43) RLGGHTPFORLLGC-UHFFFAOYSA-N 382876 US10273259, Example 587::US10273259, Example 621::US10711020, Example 621 Nuclear receptor ROR-gamma [262-507] 308 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382876 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382876&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679213 404852205 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931532 CN1[C@@H](CCC1=O)C(=O)N1CC2CCc3cc(ccc3C2(C1)S(=O)(=O)c1ccc(F)cc1)C(F)(C(F)(F)F)C(F)(F)F InChI=1S/C27H24F8N2O4S/c1-36-21(10-11-22(36)38)23(39)37-13-17-3-2-15-12-16(25(29,26(30,31)32)27(33,34)35)4-9-20(15)24(17,14-37)42(40,41)19-7-5-18(28)6-8-19/h4-9,12,17,21H,2-3,10-11,13-14H2,1H3/t17?,21-,24?/m0/s1 VAYFCOIKLQAOOP-LBVATQBMSA-N 382911 US10273259, Example 622::US10711020, Example 622 Nuclear receptor ROR-gamma [262-507] 4508 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382911 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382911&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 145995607 404852238 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931533 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CCC2(C(COc3cc(ccc23)C(F)(C(F)(F)F)C(F)(F)F)C1)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C29H27F8NO6S/c30-20-6-8-21(9-7-20)45(42,43)26-11-12-38(24(39)16-1-3-17(4-2-16)25(40)41)14-19(26)15-44-23-13-18(5-10-22(23)26)27(31,28(32,33)34)29(35,36)37/h5-10,13,16-17,19H,1-4,11-12,14-15H2,(H,40,41)/t16-,17-,19?,26? YUGCFWDORUEUGB-ZFKZCHJLSA-N 382912 US10273259, Example 623::US10273259, Example 634::US10711020, Example 634 Nuclear receptor ROR-gamma [262-507] 6586 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382912 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382912&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678733 404852239 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931534 OC(=O)C1CC2(C1)CC(C2)C(=O)N1CCC2(C(COc3cc(ccc23)C(F)(C(F)(F)F)C(F)(F)F)C1)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C30H27F8NO6S/c31-20-2-4-21(5-3-20)46(43,44)27-7-8-39(24(40)16-10-26(11-16)12-17(13-26)25(41)42)14-19(27)15-45-23-9-18(1-6-22(23)27)28(32,29(33,34)35)30(36,37)38/h1-6,9,16-17,19H,7-8,10-15H2,(H,41,42) ICDNKYIDWWRWFU-UHFFFAOYSA-N 453659 US10711020, Example 624 Nuclear receptor ROR-gamma [262-507] 1754 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=453659 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=453659&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679231 440969548 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931535 Fc1ccc(cc1)S(=O)(=O)C12CCN(CC1COc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1CCS(=O)(=O)CC1 InChI=1S/C27H25F8NO6S2/c28-19-2-4-20(5-3-19)44(40,41)24-9-10-36(23(37)16-7-11-43(38,39)12-8-16)14-18(24)15-42-22-13-17(1-6-21(22)24)25(29,26(30,31)32)27(33,34)35/h1-6,13,16,18H,7-12,14-15H2 GFPRRSCXNWMBBB-UHFFFAOYSA-N 382914 US10273259, Example 625::US10273259, Example 635::US10711020, Example 635 Nuclear receptor ROR-gamma [262-507] 425 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382914 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382914&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679097 404852241 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931536 CC(C)(O)CC(=O)N1CCC2(C(COc3cc(ccc23)C(F)(C(F)(F)F)C(F)(F)F)C1)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C26H25F8NO5S/c1-22(2,37)12-21(36)35-10-9-23(41(38,39)18-6-4-17(27)5-7-18)16(13-35)14-40-20-11-15(3-8-19(20)23)24(28,25(29,30)31)26(32,33)34/h3-8,11,16,37H,9-10,12-14H2,1-2H3 ZFJLVGNWGHIVHS-UHFFFAOYSA-N 382915 US10273259, Example 626::US10711020, Example 626 Nuclear receptor ROR-gamma [262-507] 897 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382915 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382915&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678838 404852242 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931537 CN1[C@@H](CCC1=O)C(=O)N1CCC2(C(COc3cc(ccc23)C(F)(C(F)(F)F)C(F)(F)F)C1)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C27H24F8N2O5S/c1-36-20(8-9-22(36)38)23(39)37-11-10-24(43(40,41)18-5-3-17(28)4-6-18)16(13-37)14-42-21-12-15(2-7-19(21)24)25(29,26(30,31)32)27(33,34)35/h2-7,12,16,20H,8-11,13-14H2,1H3/t16?,20-,24?/m0/s1 ODQPSMWGCHAGSW-XUGLNINTSA-N 382916 US10273259, Example 627::US10273259, Example 628::US10711020, Example 628 Nuclear receptor ROR-gamma [262-507] 1450 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382916 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382916&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678836 404852243 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931538 CN1[C@@H](CCC1=O)C(=O)N1CCC2(C(COc3cc(ccc23)C(F)(C(F)(F)F)C(F)(F)F)C1)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C27H24F8N2O5S/c1-36-20(8-9-22(36)38)23(39)37-11-10-24(43(40,41)18-5-3-17(28)4-6-18)16(13-37)14-42-21-12-15(2-7-19(21)24)25(29,26(30,31)32)27(33,34)35/h2-7,12,16,20H,8-11,13-14H2,1H3/t16?,20-,24?/m0/s1 ODQPSMWGCHAGSW-XUGLNINTSA-N 382916 US10273259, Example 627::US10273259, Example 628::US10711020, Example 628 Nuclear receptor ROR-gamma [262-507] 744 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382916 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382916&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678836 404852243 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931539 CN1[C@@H](C[C@H](F)C1=O)C(=O)N1CCC2(C(COc3cc(ccc23)C(F)(C(F)(F)F)C(F)(F)F)C1)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C27H23F9N2O5S/c1-37-20(11-19(29)22(37)39)23(40)38-9-8-24(44(41,42)17-5-3-16(28)4-6-17)15(12-38)13-43-21-10-14(2-7-18(21)24)25(30,26(31,32)33)27(34,35)36/h2-7,10,15,19-20H,8-9,11-13H2,1H3/t15?,19-,20-,24?/m0/s1 QRCCFITXDNQCMM-ZHALMGHNSA-N 382918 US10273259, Example 629::US10711020, Example 629 Nuclear receptor ROR-gamma [262-507] 3545 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382918 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382918&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 145995608 404852244 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931540 OC(=O)C1CCCC(C1)C(=O)N1CCC2(C(COc3cc(ccc23)C(F)(C(F)(F)F)C(F)(F)F)C1)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C29H27F8NO6S/c30-20-5-7-21(8-6-20)45(42,43)26-10-11-38(24(39)16-2-1-3-17(12-16)25(40)41)14-19(26)15-44-23-13-18(4-9-22(23)26)27(31,28(32,33)34)29(35,36)37/h4-9,13,16-17,19H,1-3,10-12,14-15H2,(H,40,41) UJJDMOYKXATPNI-UHFFFAOYSA-N 382919 US10273259, Example 630::US10711020, Example 630 Nuclear receptor ROR-gamma [262-507] 6753 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382919 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382919&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678738 404852245 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931541 OC(=O)C1CCC(C1)C(=O)N1CCC2(C(COc3cc(ccc23)C(F)(C(F)(F)F)C(F)(F)F)C1)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H25F8NO6S/c29-19-4-6-20(7-5-19)44(41,42)25-9-10-37(23(38)15-1-2-16(11-15)24(39)40)13-18(25)14-43-22-12-17(3-8-21(22)25)26(30,27(31,32)33)28(34,35)36/h3-8,12,15-16,18H,1-2,9-11,13-14H2,(H,39,40) XHDZXSUWYPVGCI-UHFFFAOYSA-N 382920 US10273259, Example 631::US10711020, Example 631 Nuclear receptor ROR-gamma [262-507] 1701 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382920 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382920&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679089 404852246 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931542 C[C@@]1(CC[C@@H](CC1)C(O)=O)C(=O)N1CCC2(C(COc3cc(ccc23)C(F)(C(F)(F)F)C(F)(F)F)C1)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C30H29F8NO6S/c1-26(10-8-17(9-11-26)24(40)41)25(42)39-13-12-27(46(43,44)21-5-3-20(31)4-6-21)19(15-39)16-45-23-14-18(2-7-22(23)27)28(32,29(33,34)35)30(36,37)38/h2-7,14,17,19H,8-13,15-16H2,1H3,(H,40,41)/t17-,19?,26-,27? YSGHQSVQDYLDHX-VRMBQRHRSA-N 382921 US10273259, Example 632::US10711020, Example 632 Nuclear receptor ROR-gamma [262-507] 5779 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382921 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382921&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678741 404852247 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931543 OC(=O)[C@H]1CC[C@@](O)(CC1)C(=O)N1CCC2(C(COc3cc(ccc23)C(F)(C(F)(F)F)C(F)(F)F)C1)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C29H27F8NO7S/c30-19-2-4-20(5-3-19)46(43,44)26-11-12-38(24(41)25(42)9-7-16(8-10-25)23(39)40)14-18(26)15-45-22-13-17(1-6-21(22)26)27(31,28(32,33)34)29(35,36)37/h1-6,13,16,18,42H,7-12,14-15H2,(H,39,40)/t16-,18?,25+,26? AIHAKTVYKDNOJD-HTHZVERSSA-N 382922 US10273259, Example 633::US10711020, Example 633 Nuclear receptor ROR-gamma [262-507] 249 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382922 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382922&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679094 404852248 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931544 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CCC2(C(COc3cc(ccc23)C(F)(C(F)(F)F)C(F)(F)F)C1)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C29H27F8NO6S/c30-20-6-8-21(9-7-20)45(42,43)26-11-12-38(24(39)16-1-3-17(4-2-16)25(40)41)14-19(26)15-44-23-13-18(5-10-22(23)26)27(31,28(32,33)34)29(35,36)37/h5-10,13,16-17,19H,1-4,11-12,14-15H2,(H,40,41)/t16-,17-,19?,26? YUGCFWDORUEUGB-ZFKZCHJLSA-N 382912 US10273259, Example 623::US10273259, Example 634::US10711020, Example 634 Nuclear receptor ROR-gamma [262-507] 5967 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382912 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382912&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678733 404852239 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931545 Fc1ccc(cc1)S(=O)(=O)C12CCN(CC1COc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1CCS(=O)(=O)CC1 InChI=1S/C27H25F8NO6S2/c28-19-2-4-20(5-3-19)44(40,41)24-9-10-36(23(37)16-7-11-43(38,39)12-8-16)14-18(24)15-42-22-13-17(1-6-21(22)24)25(29,26(30,31)32)27(33,34)35/h1-6,13,16,18H,7-12,14-15H2 GFPRRSCXNWMBBB-UHFFFAOYSA-N 382914 US10273259, Example 625::US10273259, Example 635::US10711020, Example 635 Nuclear receptor ROR-gamma [262-507] 4957 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382914 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382914&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679097 404852241 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931546 CCNC(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C24H22F8N2O3S/c1-2-33-20(35)34-12-11-21(38(36,37)17-7-5-16(25)6-8-17)18-9-4-15(13-14(18)3-10-19(21)34)22(26,23(27,28)29)24(30,31)32/h4-9,13,19H,2-3,10-12H2,1H3,(H,33,35)/t19-,21-/m1/s1 LKBKHFSEJYFWRW-TZIWHRDSSA-N 382925 (3aR,9bR)—N-ethyl-9b-((4-fluorophenyl)sulfonyl)-7-perfluoropropan-2-yl)-1,2,3a,4,5,9b-hexahydro-3H-benzo[e]indole-3-carboxamide::US10273259, Example 636::US10711020, Example 636 Nuclear receptor ROR-gamma [262-507] 171 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382925 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382925&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122669211 404852249 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931547 CC1CN(CCC1C(O)=O)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C29H28F8N2O5S/c1-16-15-38(12-10-21(16)24(40)41)25(42)39-13-11-26(45(43,44)20-6-4-19(30)5-7-20)22-8-3-18(14-17(22)2-9-23(26)39)27(31,28(32,33)34)29(35,36)37/h3-8,14,16,21,23H,2,9-13,15H2,1H3,(H,40,41)/t16?,21?,23-,26-/m1/s1 JHUZNZHWSOZRLD-AAPRQYKCSA-N 382926 1-((3aR,9bR)-9b-((4-fluorophenyl)sulfonyl)-7-(perfluoropropan-2-yl)-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]indole-3-carbonyl)-3-methylpiperidine-4-carboxylic acid::US10273259, Example 637::US10273259, Example 638::US10273259, Example 639::US10273259, Example 640::US10711020, Example 640 Nuclear receptor ROR-gamma [262-507] 92.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382926 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382926&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122669143 404852250 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931548 CC1CN(CCC1C(O)=O)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C29H28F8N2O5S/c1-16-15-38(12-10-21(16)24(40)41)25(42)39-13-11-26(45(43,44)20-6-4-19(30)5-7-20)22-8-3-18(14-17(22)2-9-23(26)39)27(31,28(32,33)34)29(35,36)37/h3-8,14,16,21,23H,2,9-13,15H2,1H3,(H,40,41)/t16?,21?,23-,26-/m1/s1 JHUZNZHWSOZRLD-AAPRQYKCSA-N 382926 1-((3aR,9bR)-9b-((4-fluorophenyl)sulfonyl)-7-(perfluoropropan-2-yl)-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]indole-3-carbonyl)-3-methylpiperidine-4-carboxylic acid::US10273259, Example 637::US10273259, Example 638::US10273259, Example 639::US10273259, Example 640::US10711020, Example 640 Nuclear receptor ROR-gamma [262-507] 70.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382926 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382926&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122669143 404852250 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931549 CC1CN(CCC1C(O)=O)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C29H28F8N2O5S/c1-16-15-38(12-10-21(16)24(40)41)25(42)39-13-11-26(45(43,44)20-6-4-19(30)5-7-20)22-8-3-18(14-17(22)2-9-23(26)39)27(31,28(32,33)34)29(35,36)37/h3-8,14,16,21,23H,2,9-13,15H2,1H3,(H,40,41)/t16?,21?,23-,26-/m1/s1 JHUZNZHWSOZRLD-AAPRQYKCSA-N 382926 1-((3aR,9bR)-9b-((4-fluorophenyl)sulfonyl)-7-(perfluoropropan-2-yl)-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]indole-3-carbonyl)-3-methylpiperidine-4-carboxylic acid::US10273259, Example 637::US10273259, Example 638::US10273259, Example 639::US10273259, Example 640::US10711020, Example 640 Nuclear receptor ROR-gamma [262-507] 23.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382926 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382926&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122669143 404852250 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931550 CC1CN(CCC1C(O)=O)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C29H28F8N2O5S/c1-16-15-38(12-10-21(16)24(40)41)25(42)39-13-11-26(45(43,44)20-6-4-19(30)5-7-20)22-8-3-18(14-17(22)2-9-23(26)39)27(31,28(32,33)34)29(35,36)37/h3-8,14,16,21,23H,2,9-13,15H2,1H3,(H,40,41)/t16?,21?,23-,26-/m1/s1 JHUZNZHWSOZRLD-AAPRQYKCSA-N 382926 1-((3aR,9bR)-9b-((4-fluorophenyl)sulfonyl)-7-(perfluoropropan-2-yl)-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]indole-3-carbonyl)-3-methylpiperidine-4-carboxylic acid::US10273259, Example 637::US10273259, Example 638::US10273259, Example 639::US10273259, Example 640::US10711020, Example 640 Nuclear receptor ROR-gamma [262-507] 51.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382926 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382926&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122669143 404852250 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931551 CC1CN(CCC1C(O)=O)C(=O)N1CCC2(C1COc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H26F8N2O6S/c1-15-13-37(10-8-19(15)23(39)40)24(41)38-11-9-25(45(42,43)18-5-3-17(29)4-6-18)20-7-2-16(12-21(20)44-14-22(25)38)26(30,27(31,32)33)28(34,35)36/h2-7,12,15,19,22H,8-11,13-14H2,1H3,(H,39,40) DMJJKCSHNFWGGD-UHFFFAOYSA-N 382930 US10273259, Example 641::US10273259, Example 642::US10711020, Example 642 Nuclear receptor ROR-gamma [262-507] 83.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382930 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382930&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678862 404852251 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931552 CC1CN(CCC1C(O)=O)C(=O)N1CCC2(C1COc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H26F8N2O6S/c1-15-13-37(10-8-19(15)23(39)40)24(41)38-11-9-25(45(42,43)18-5-3-17(29)4-6-18)20-7-2-16(12-21(20)44-14-22(25)38)26(30,27(31,32)33)28(34,35)36/h2-7,12,15,19,22H,8-11,13-14H2,1H3,(H,39,40) DMJJKCSHNFWGGD-UHFFFAOYSA-N 382930 US10273259, Example 641::US10273259, Example 642::US10711020, Example 642 Nuclear receptor ROR-gamma [262-507] 156 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382930 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382930&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678862 404852251 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931553 OC(=O)C1(O)CCN(CC1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H26F8N2O6S/c29-18-3-5-19(6-4-18)45(43,44)25-11-14-38(23(41)37-12-9-24(42,10-13-37)22(39)40)21(25)8-1-16-15-17(2-7-20(16)25)26(30,27(31,32)33)28(34,35)36/h2-7,15,21,42H,1,8-14H2,(H,39,40)/t21-,25-/m1/s1 IWVANVDDDFZNAS-PXDATVDWSA-N 382932 US10273259, Example 643::US10711020, Example 643 Nuclear receptor ROR-gamma [262-507] 161 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382932 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382932&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678877 404852252 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931554 OC(=O)N1CCN(CC1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C27H25F8N3O5S/c28-18-3-5-19(6-4-18)44(42,43)24-9-10-38(22(39)36-11-13-37(14-12-36)23(40)41)21(24)8-1-16-15-17(2-7-20(16)24)25(29,26(30,31)32)27(33,34)35/h2-7,15,21H,1,8-14H2,(H,40,41)/t21-,24-/m1/s1 ZRVXALGQGSKDOI-ZJSXRUAMSA-N 453679 US10711020, Example 644 Nuclear receptor ROR-gamma [262-507] 34.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=453679 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=453679&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 139386992 440969568 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931555 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)NC1CCOCC1 InChI=1S/C27H26F8N2O4S/c28-18-3-5-20(6-4-18)42(39,40)24-11-12-37(23(38)36-19-9-13-41-14-10-19)22(24)8-1-16-15-17(2-7-21(16)24)25(29,26(30,31)32)27(33,34)35/h2-7,15,19,22H,1,8-14H2,(H,36,38)/t22-,24-/m1/s1 ONUATVHRHOYOBG-ISKFKSNPSA-N 382934 US10273259, Example 645::US10711020, Example 645 Nuclear receptor ROR-gamma [262-507] 22.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382934 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382934&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679253 404852254 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931556 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)Nc1ccncc1 InChI=1S/C27H21F8N3O3S/c28-18-3-5-20(6-4-18)42(40,41)24-11-14-38(23(39)37-19-9-12-36-13-10-19)22(24)8-1-16-15-17(2-7-21(16)24)25(29,26(30,31)32)27(33,34)35/h2-7,9-10,12-13,15,22H,1,8,11,14H2,(H,36,37,39)/t22-,24-/m1/s1 HBERPHXXGYULDT-ISKFKSNPSA-N 382935 US10273259, Example 646::US10711020, Example 646 Nuclear receptor ROR-gamma [262-507] 30.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382935 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382935&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679223 404852255 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931557 CC(C)(O)CNC(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C26H26F8N2O4S/c1-22(2,38)14-35-21(37)36-12-11-23(41(39,40)18-7-5-17(27)6-8-18)19-9-4-16(13-15(19)3-10-20(23)36)24(28,25(29,30)31)26(32,33)34/h4-9,13,20,38H,3,10-12,14H2,1-2H3,(H,35,37)/t20-,23-/m1/s1 AYYPMMBZWYNXND-NFBKMPQASA-N 382936 US10273259, Example 647::US10711020, Example 647 Nuclear receptor ROR-gamma [262-507] 37.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382936 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382936&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679038 404852256 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931558 CC(C)(O)CCNC(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C27H28F8N2O4S/c1-23(2,39)11-13-36-22(38)37-14-12-24(42(40,41)19-7-5-18(28)6-8-19)20-9-4-17(15-16(20)3-10-21(24)37)25(29,26(30,31)32)27(33,34)35/h4-9,15,21,39H,3,10-14H2,1-2H3,(H,36,38)/t21-,24-/m1/s1 NNHDCRJVOBNWPH-ZJSXRUAMSA-N 382937 US10273259, Example 648::US10711020, Example 648 Nuclear receptor ROR-gamma [262-507] 31.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382937 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382937&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678882 404852257 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931559 CC(C)(O)[C@H](F)CNC(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C27H27F9N2O4S/c1-23(2,40)20(29)14-37-22(39)38-12-11-24(43(41,42)18-7-5-17(28)6-8-18)19-9-4-16(13-15(19)3-10-21(24)38)25(30,26(31,32)33)27(34,35)36/h4-9,13,20-21,40H,3,10-12,14H2,1-2H3,(H,37,39)/t20-,21-,24-/m1/s1 UKIAFMXJMJVHSC-PQNGQFLHSA-N 382938 US10273259, Example 649::US10711020, Example 649 Nuclear receptor ROR-gamma [262-507] 32.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382938 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382938&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678743 404852258 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931560 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)Nc1ccnnc1 InChI=1S/C26H20F8N4O3S/c27-17-3-5-19(6-4-17)42(40,41)23-10-12-38(22(39)37-18-9-11-35-36-14-18)21(23)8-1-15-13-16(2-7-20(15)23)24(28,25(29,30)31)26(32,33)34/h2-7,9,11,13-14,21H,1,8,10,12H2,(H,35,37,39)/t21-,23-/m1/s1 IGUMWSPIYUZTAI-FYYLOGMGSA-N 382939 US10273259, Example 650::US10711020, Example 650 Nuclear receptor ROR-gamma [262-507] 86.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382939 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382939&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679081 404852259 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931561 OC(=O)[C@@H]1CCCN(C1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H26F8N2O5S/c29-19-5-7-20(8-6-19)44(42,43)25-11-13-38(24(41)37-12-1-2-17(15-37)23(39)40)22(25)10-3-16-14-18(4-9-21(16)25)26(30,27(31,32)33)28(34,35)36/h4-9,14,17,22H,1-3,10-13,15H2,(H,39,40)/t17-,22-,25-/m1/s1 PRURFRCVWVOAKR-CFRFINDLSA-N 382940 US10273259, Example 651::US10711020, Example 651 Nuclear receptor ROR-gamma [262-507] 278 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382940 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382940&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679233 404852260 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931562 OC(=O)C1CCN(CC1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H26F8N2O5S/c29-19-3-5-20(6-4-19)44(42,43)25-11-14-38(24(41)37-12-9-16(10-13-37)23(39)40)22(25)8-1-17-15-18(2-7-21(17)25)26(30,27(31,32)33)28(34,35)36/h2-7,15-16,22H,1,8-14H2,(H,39,40)/t22-,25-/m1/s1 MXLBLRQWSDBOJA-RCZVLFRGSA-N 382941 US10273259, Example 652::US10711020, Example 652 Nuclear receptor ROR-gamma [262-507] 115 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382941 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382941&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678764 404852261 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931563 OC(=O)[C@H]1CCCN(C1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H26F8N2O5S/c29-19-5-7-20(8-6-19)44(42,43)25-11-13-38(24(41)37-12-1-2-17(15-37)23(39)40)22(25)10-3-16-14-18(4-9-21(16)25)26(30,27(31,32)33)28(34,35)36/h4-9,14,17,22H,1-3,10-13,15H2,(H,39,40)/t17-,22+,25+/m0/s1 PRURFRCVWVOAKR-CBCWYDDASA-N 382942 US10273259, Example 653::US10711020, Example 653 Nuclear receptor ROR-gamma [262-507] 64.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382942 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382942&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678742 404852262 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931564 OC(=O)C1CCN(CC1)S(=O)(=O)N1CCC2(C1Cc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C26H24F8N2O6S2/c27-18-2-4-19(5-3-18)43(39,40)23-9-12-36(44(41,42)35-10-7-15(8-11-35)22(37)38)21(23)14-16-13-17(1-6-20(16)23)24(28,25(29,30)31)26(32,33)34/h1-6,13,15,21H,7-12,14H2,(H,37,38) CLJUYYRVVUBGCI-UHFFFAOYSA-N 382943 US10273259, Example 654::US10711020, Example 654 Nuclear receptor ROR-gamma [262-507] 4676 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382943 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382943&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679244 404852263 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931565 Fc1ccc(cc1)S(=O)(=O)C12CCN(C1Cc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)NC1CCOCC1 InChI=1S/C26H24F8N2O4S/c27-17-2-4-19(5-3-17)41(38,39)23-9-10-36(22(37)35-18-7-11-40-12-8-18)21(23)14-15-13-16(1-6-20(15)23)24(28,25(29,30)31)26(32,33)34/h1-6,13,18,21H,7-12,14H2,(H,35,37) OCQDYRGXGGPYLB-UHFFFAOYSA-N 382944 US10273259, Example 655::US10711020, Example 655 Nuclear receptor ROR-gamma [262-507] 1175 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382944 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382944&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679236 404852264 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931566 CC(C)(O)CNC(=O)N1CCC2(C1Cc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C25H24F8N2O4S/c1-21(2,37)13-34-20(36)35-10-9-22(40(38,39)17-6-4-16(26)5-7-17)18-8-3-15(11-14(18)12-19(22)35)23(27,24(28,29)30)25(31,32)33/h3-8,11,19,37H,9-10,12-13H2,1-2H3,(H,34,36) BVMFCTGBLBEZTL-UHFFFAOYSA-N 382945 US10273259, Example 656::US10711020, Example 656 Nuclear receptor ROR-gamma [262-507] 1380 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382945 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382945&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679099 404852265 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931567 OC(=O)C1CCN(CC1)C(=O)N1CCC2(C1Cc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C27H24F8N2O5S/c28-18-2-4-19(5-3-18)43(41,42)24-9-12-37(23(40)36-10-7-15(8-11-36)22(38)39)21(24)14-16-13-17(1-6-20(16)24)25(29,26(30,31)32)27(33,34)35/h1-6,13,15,21H,7-12,14H2,(H,38,39) ZERAJJWDUHTGAJ-UHFFFAOYSA-N 382946 US10273259, Example 657::US10711020, Example 657 Nuclear receptor ROR-gamma [262-507] 38.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382946 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382946&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679069 404852266 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931568 CC(C)(O)CCNC(=O)N1CCC2(C1Cc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C26H26F8N2O4S/c1-22(2,38)9-11-35-21(37)36-12-10-23(41(39,40)18-6-4-17(27)5-7-18)19-8-3-16(13-15(19)14-20(23)36)24(28,25(29,30)31)26(32,33)34/h3-8,13,20,38H,9-12,14H2,1-2H3,(H,35,37) GHQBHJDDESLOGZ-UHFFFAOYSA-N 382947 US10273259, Example 658::US10711020, Example 658 Nuclear receptor ROR-gamma [262-507] 1269 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382947 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382947&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679251 404852267 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931569 CC(C)(O)CNC(=O)N1CC2CCc3cc(ccc3C2(C1)S(=O)(=O)c1ccc(F)cc1)C(F)(C(F)(F)F)C(F)(F)F InChI=1S/C26H26F8N2O4S/c1-22(2,38)13-35-21(37)36-12-17-4-3-15-11-16(24(28,25(29,30)31)26(32,33)34)5-10-20(15)23(17,14-36)41(39,40)19-8-6-18(27)7-9-19/h5-11,17,38H,3-4,12-14H2,1-2H3,(H,35,37) NFVJVVVFZUHLOG-UHFFFAOYSA-N 382948 US10273259, Example 659::US10711020, Example 659 Nuclear receptor ROR-gamma [262-507] 340 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382948 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382948&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679258 404852268 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931570 CC1CN(CCC1C(O)=O)C(=O)N1CC2CCc3cc(ccc3C2(C1)S(=O)(=O)c1ccc(F)cc1)C(F)(C(F)(F)F)C(F)(F)F InChI=1S/C29H28F8N2O5S/c1-16-13-38(11-10-22(16)24(40)41)25(42)39-14-19-3-2-17-12-18(27(31,28(32,33)34)29(35,36)37)4-9-23(17)26(19,15-39)45(43,44)21-7-5-20(30)6-8-21/h4-9,12,16,19,22H,2-3,10-11,13-15H2,1H3,(H,40,41) XATIWMZAXMBEPE-UHFFFAOYSA-N 382949 US10273259, Example 660::US10273259, Example 662::US10711020, Example 662 Nuclear receptor ROR-gamma [262-507] 174 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382949 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382949&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678848 404852269 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931571 COC(=O)C1CCN(CC1C)C(=O)N1CC2CCc3cc(ccc3C2(C1)S(=O)(=O)c1ccc(F)cc1)C(F)(C(F)(F)F)C(F)(F)F InChI=1S/C30H30F8N2O5S/c1-17-14-39(12-11-23(17)25(41)45-2)26(42)40-15-20-4-3-18-13-19(28(32,29(33,34)35)30(36,37)38)5-10-24(18)27(20,16-40)46(43,44)22-8-6-21(31)7-9-22/h5-10,13,17,20,23H,3-4,11-12,14-16H2,1-2H3 FVWNIKIQLYBQGY-UHFFFAOYSA-N 382950 US10273259, Example 661::US10273259, Example 663::US10711020, Example 663 Nuclear receptor ROR-gamma [262-507] 10.00 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382950 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382950&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679240 404852270 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931572 CC1CN(CCC1C(O)=O)C(=O)N1CC2CCc3cc(ccc3C2(C1)S(=O)(=O)c1ccc(F)cc1)C(F)(C(F)(F)F)C(F)(F)F InChI=1S/C29H28F8N2O5S/c1-16-13-38(11-10-22(16)24(40)41)25(42)39-14-19-3-2-17-12-18(27(31,28(32,33)34)29(35,36)37)4-9-23(17)26(19,15-39)45(43,44)21-7-5-20(30)6-8-21/h4-9,12,16,19,22H,2-3,10-11,13-15H2,1H3,(H,40,41) XATIWMZAXMBEPE-UHFFFAOYSA-N 382949 US10273259, Example 660::US10273259, Example 662::US10711020, Example 662 Nuclear receptor ROR-gamma [262-507] 546 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382949 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382949&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678848 404852269 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931573 COC(=O)C1CCN(CC1C)C(=O)N1CC2CCc3cc(ccc3C2(C1)S(=O)(=O)c1ccc(F)cc1)C(F)(C(F)(F)F)C(F)(F)F InChI=1S/C30H30F8N2O5S/c1-17-14-39(12-11-23(17)25(41)45-2)26(42)40-15-20-4-3-18-13-19(28(32,29(33,34)35)30(36,37)38)5-10-24(18)27(20,16-40)46(43,44)22-8-6-21(31)7-9-22/h5-10,13,17,20,23H,3-4,11-12,14-16H2,1-2H3 FVWNIKIQLYBQGY-UHFFFAOYSA-N 382950 US10273259, Example 661::US10273259, Example 663::US10711020, Example 663 Nuclear receptor ROR-gamma [262-507] 1613 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382950 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382950&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679240 404852270 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931574 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)NC1CCS(=O)(=O)CC1 InChI=1S/C27H26F8N2O5S2/c28-18-3-5-20(6-4-18)44(41,42)24-11-12-37(23(38)36-19-9-13-43(39,40)14-10-19)22(24)8-1-16-15-17(2-7-21(16)24)25(29,26(30,31)32)27(33,34)35/h2-7,15,19,22H,1,8-14H2,(H,36,38)/t22-,24-/m1/s1 XGPWZCSOAMGQEU-ISKFKSNPSA-N 382953 US10273259, Example 664::US10711020, Example 664 Nuclear receptor ROR-gamma [262-507] 23.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382953 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382953&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679119 404852271 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931575 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)NCC1CCS(=O)(=O)CC1 InChI=1S/C28H28F8N2O5S2/c29-20-3-5-21(6-4-20)45(42,43)25-11-12-38(24(39)37-16-17-9-13-44(40,41)14-10-17)23(25)8-1-18-15-19(2-7-22(18)25)26(30,27(31,32)33)28(34,35)36/h2-7,15,17,23H,1,8-14,16H2,(H,37,39)/t23-,25-/m1/s1 OZSZNLKIRBSEAE-ILBGXUMGSA-N 382954 US10273259, Example 665::US10711020, Example 665 Nuclear receptor ROR-gamma [262-507] 15.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382954 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382954&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678686 404852272 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931576 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)N1CCS(=O)(=O)CC1 InChI=1S/C26H24F8N2O5S2/c27-18-3-5-19(6-4-18)43(40,41)23-9-10-36(22(37)35-11-13-42(38,39)14-12-35)21(23)8-1-16-15-17(2-7-20(16)23)24(28,25(29,30)31)26(32,33)34/h2-7,15,21H,1,8-14H2/t21-,23-/m1/s1 PTRKYEOXRKXYKH-FYYLOGMGSA-N 382955 US10273259, Example 666::US10711020, Example 666 Nuclear receptor ROR-gamma [262-507] 48.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382955 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382955&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678711 404852273 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931577 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)NCC1CCS(=O)(=O)C1 InChI=1S/C27H26F8N2O5S2/c28-19-3-5-20(6-4-19)44(41,42)24-10-11-37(23(38)36-14-16-9-12-43(39,40)15-16)22(24)8-1-17-13-18(2-7-21(17)24)25(29,26(30,31)32)27(33,34)35/h2-7,13,16,22H,1,8-12,14-15H2,(H,36,38)/t16?,22-,24-/m1/s1 FGXHDTAXBYJCLZ-QOPVDAPCSA-N 382967 US10273259, Example 678::US10273259, Example 679::US10711020, Example 679 Nuclear receptor ROR-gamma [262-507] 17.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382967 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382967&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679100 404852284 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931578 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)NC1CCS(=O)(=O)C1 InChI=1S/C26H24F8N2O5S2/c27-17-3-5-19(6-4-17)43(40,41)23-10-11-36(22(37)35-18-9-12-42(38,39)14-18)21(23)8-1-15-13-16(2-7-20(15)23)24(28,25(29,30)31)26(32,33)34/h2-7,13,18,21H,1,8-12,14H2,(H,35,37)/t18?,21-,23-/m1/s1 BALSXRCVZGNGOG-QOYLUPDXSA-N 453703 US10711020, Example 668 Nuclear receptor ROR-gamma [262-507] 47.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=453703 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=453703&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679129 440969592 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931579 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)N1CC(C1)N1CCS(=O)(=O)CC1 InChI=1S/C29H29F8N3O5S2/c30-20-3-5-22(6-4-20)47(44,45)26-9-10-40(25(41)39-16-21(17-39)38-11-13-46(42,43)14-12-38)24(26)8-1-18-15-19(2-7-23(18)26)27(31,28(32,33)34)29(35,36)37/h2-7,15,21,24H,1,8-14,16-17H2/t24-,26-/m1/s1 RDYDOEMKXIJFHH-AOYPEHQESA-N 382958 US10273259, Example 669::US10711020, Example 669 Nuclear receptor ROR-gamma [262-507] 39.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382958 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382958&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679249 404852276 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931580 CC1CS(=O)(=O)CCN1C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C27H26F8N2O5S2/c1-16-15-43(39,40)13-12-36(16)23(38)37-11-10-24(44(41,42)20-6-4-19(28)5-7-20)21-8-3-18(14-17(21)2-9-22(24)37)25(29,26(30,31)32)27(33,34)35/h3-8,14,16,22H,2,9-13,15H2,1H3/t16?,22-,24-/m1/s1 QYNCLJBULIZGFP-QOPVDAPCSA-N 382959 US10273259, Example 670::US10711020, Example 670 Nuclear receptor ROR-gamma [262-507] 24.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382959 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382959&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678859 404852277 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931581 CN(C1CCS(=O)(=O)C1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C27H26F8N2O5S2/c1-36(19-10-13-43(39,40)15-19)23(38)37-12-11-24(44(41,42)20-6-4-18(28)5-7-20)21-8-3-17(14-16(21)2-9-22(24)37)25(29,26(30,31)32)27(33,34)35/h3-8,14,19,22H,2,9-13,15H2,1H3/t19?,22-,24-/m1/s1 UIXBKKDQMQOIHY-WXEBLKNKSA-N 453706 US10711020, Example 671 Nuclear receptor ROR-gamma [262-507] 32.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=453706 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=453706&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679235 440969595 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931582 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)N(C1CC1)C1CCS(=O)(=O)C1 InChI=1S/C29H28F8N2O5S2/c30-19-3-7-22(8-4-19)46(43,44)26-12-13-38(25(40)39(20-5-6-20)21-11-14-45(41,42)16-21)24(26)10-1-17-15-18(2-9-23(17)26)27(31,28(32,33)34)29(35,36)37/h2-4,7-9,15,20-21,24H,1,5-6,10-14,16H2/t21?,24-,26-/m1/s1 FYCYKRHVNIOIMO-GVCDQIDYSA-N 453707 US10711020, Example 672 Nuclear receptor ROR-gamma [262-507] 65.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=453707 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=453707&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678874 440969596 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931583 CC(=O)NC1CS(=O)(=O)CCC1NC(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C29H29F8N3O6S2/c1-16(41)38-23-15-47(43,44)13-10-22(23)39-25(42)40-12-11-26(48(45,46)20-6-4-19(30)5-7-20)21-8-3-18(14-17(21)2-9-24(26)40)27(31,28(32,33)34)29(35,36)37/h3-8,14,22-24H,2,9-13,15H2,1H3,(H,38,41)(H,39,42)/t22?,23?,24-,26-/m1/s1 UMHRTWJGSIYIHV-SFASGRJPSA-N 453708 US10711020, Example 673 Nuclear receptor ROR-gamma [262-507] 39.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=453708 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=453708&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678844 440969597 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931584 OC1CS(=O)(=O)CC1NC(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C26H24F8N2O6S2/c27-16-3-5-17(6-4-16)44(41,42)23-9-10-36(22(38)35-19-12-43(39,40)13-20(19)37)21(23)8-1-14-11-15(2-7-18(14)23)24(28,25(29,30)31)26(32,33)34/h2-7,11,19-21,37H,1,8-10,12-13H2,(H,35,38)/t19?,20?,21-,23-/m1/s1 ZBRROVURFKFQJX-UPSGKMMVSA-N 453709 US10711020, Example 674 Nuclear receptor ROR-gamma [262-507] 51.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=453709 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=453709&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679234 440969598 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931585 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)NC1CCS(=O)(=O)C1 InChI=1S/C26H24F8N2O5S2/c27-17-3-5-19(6-4-17)43(40,41)23-10-11-36(22(37)35-18-9-12-42(38,39)14-18)21(23)8-1-15-13-16(2-7-20(15)23)24(28,25(29,30)31)26(32,33)34/h2-7,13,18,21H,1,8-12,14H2,(H,35,37)/t18?,21-,23-/m1/s1 BALSXRCVZGNGOG-QOYLUPDXSA-N 382964 US10273259, Example 675::US10273259, Example 676::US10711020, Example 676 Nuclear receptor ROR-gamma [262-507] 57.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382964 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382964&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679129 404852282 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931586 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)NC1CCS(=O)(=O)C1 InChI=1S/C26H24F8N2O5S2/c27-17-3-5-19(6-4-17)43(40,41)23-10-11-36(22(37)35-18-9-12-42(38,39)14-18)21(23)8-1-15-13-16(2-7-20(15)23)24(28,25(29,30)31)26(32,33)34/h2-7,13,18,21H,1,8-12,14H2,(H,35,37)/t18?,21-,23-/m1/s1 BALSXRCVZGNGOG-QOYLUPDXSA-N 382964 US10273259, Example 675::US10273259, Example 676::US10711020, Example 676 Nuclear receptor ROR-gamma [262-507] 48.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382964 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382964&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679129 404852282 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931587 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)N1CCNC2CS(=O)(=O)CC12 InChI=1S/C28H27F8N3O5S2/c29-18-3-5-19(6-4-18)46(43,44)25-9-11-39(24(40)38-12-10-37-21-14-45(41,42)15-22(21)38)23(25)8-1-16-13-17(2-7-20(16)25)26(30,27(31,32)33)28(34,35)36/h2-7,13,21-23,37H,1,8-12,14-15H2/t21?,22?,23-,25-/m1/s1 KQSRNXPQNAWNLP-WXOOSPASSA-N 382966 US10273259, Example 677::US10711020, Example 677 Nuclear receptor ROR-gamma [262-507] 79.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382966 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382966&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679248 404852283 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931588 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)NCC1CCS(=O)(=O)C1 InChI=1S/C27H26F8N2O5S2/c28-19-3-5-20(6-4-19)44(41,42)24-10-11-37(23(38)36-14-16-9-12-43(39,40)15-16)22(24)8-1-17-13-18(2-7-21(17)24)25(29,26(30,31)32)27(33,34)35/h2-7,13,16,22H,1,8-12,14-15H2,(H,36,38)/t16?,22-,24-/m1/s1 FGXHDTAXBYJCLZ-QOPVDAPCSA-N 382967 US10273259, Example 678::US10273259, Example 679::US10711020, Example 679 Nuclear receptor ROR-gamma [262-507] 105 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382967 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382967&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679100 404852284 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931589 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)NCC1CCS(=O)(=O)C1 InChI=1S/C27H26F8N2O5S2/c28-19-3-5-20(6-4-19)44(41,42)24-10-11-37(23(38)36-14-16-9-12-43(39,40)15-16)22(24)8-1-17-13-18(2-7-21(17)24)25(29,26(30,31)32)27(33,34)35/h2-7,13,16,22H,1,8-12,14-15H2,(H,36,38)/t16?,22-,24-/m1/s1 FGXHDTAXBYJCLZ-QOPVDAPCSA-N 382967 US10273259, Example 678::US10273259, Example 679::US10711020, Example 679 Nuclear receptor ROR-gamma [262-507] 231 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382967 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382967&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679100 404852284 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931590 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)N1C[C@@H]2C[C@H]1CS2(=O)=O InChI=1S/C27H24F8N2O5S2/c28-17-3-5-19(6-4-17)44(41,42)24-9-10-36(23(38)37-13-20-12-18(37)14-43(20,39)40)22(24)8-1-15-11-16(2-7-21(15)24)25(29,26(30,31)32)27(33,34)35/h2-7,11,18,20,22H,1,8-10,12-14H2/t18-,20-,22+,24+/m0/s1 DNITVOXCCINEJP-YCYVKTGYSA-N 382969 US10273259, Example 680::US10711020, Example 680 Nuclear receptor ROR-gamma [262-507] 151 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382969 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382969&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679074 404852285 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931591 CN(C1CCOCC1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H28F8N2O4S/c1-37(20-10-14-42-15-11-20)24(39)38-13-12-25(43(40,41)21-6-4-19(29)5-7-21)22-8-3-18(16-17(22)2-9-23(25)38)26(30,27(31,32)33)28(34,35)36/h3-8,16,20,23H,2,9-15H2,1H3/t23-,25-/m1/s1 HRNUXDBLBPTVKM-ILBGXUMGSA-N 382970 US10273259, Example 681::US10711020, Example 681 Nuclear receptor ROR-gamma [262-507] 193 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382970 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382970&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678890 404852286 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931592 CS(=O)(=O)N1CCN(CC1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C27H27F8N3O5S2/c1-44(40,41)37-14-12-36(13-15-37)23(39)38-11-10-24(45(42,43)20-6-4-19(28)5-7-20)21-8-3-18(16-17(21)2-9-22(24)38)25(29,26(30,31)32)27(33,34)35/h3-8,16,22H,2,9-15H2,1H3/t22-,24-/m1/s1 IRUAZYZASURAHM-ISKFKSNPSA-N 382971 US10273259, Example 682::US10711020, Example 682 Nuclear receptor ROR-gamma [262-507] 159 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382971 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382971&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679133 404852287 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931593 CS(=O)(=O)N1CCC(CC1)NC(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H29F8N3O5S2/c1-45(41,42)38-13-10-20(11-14-38)37-24(40)39-15-12-25(46(43,44)21-6-4-19(29)5-7-21)22-8-3-18(16-17(22)2-9-23(25)39)26(30,27(31,32)33)28(34,35)36/h3-8,16,20,23H,2,9-15H2,1H3,(H,37,40)/t23-,25-/m1/s1 YTIIUMWVHSWJMX-ILBGXUMGSA-N 382972 US10273259, Example 683::US10711020, Example 683 Nuclear receptor ROR-gamma [262-507] 210 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382972 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382972&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679254 404852288 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931594 CS(=O)(=O)C1CCC(CC1)NC(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C29H30F8N2O5S2/c1-45(41,42)21-10-6-20(7-11-21)38-25(40)39-15-14-26(46(43,44)22-8-4-19(30)5-9-22)23-12-3-18(16-17(23)2-13-24(26)39)27(31,28(32,33)34)29(35,36)37/h3-5,8-9,12,16,20-21,24H,2,6-7,10-11,13-15H2,1H3,(H,38,40)/t20?,21?,24-,26-/m1/s1 FGAUFDNSMRAGSL-ZCYSNTRLSA-N 382973 US10273259, Example 684::US10711020, Example 684 Nuclear receptor ROR-gamma [262-507] 243 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382973 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382973&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679107 404852289 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931595 CN1CC2N(CCC2(c2ccc(cc12)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1)C(=O)[C@H]1CC[C@@H](CC1)C(O)=O InChI=1S/C29H28F8N2O5S/c1-38-15-23-26(45(43,44)20-9-7-19(30)8-10-20,12-13-39(23)24(40)16-2-4-17(5-3-16)25(41)42)21-11-6-18(14-22(21)38)27(31,28(32,33)34)29(35,36)37/h6-11,14,16-17,23H,2-5,12-13,15H2,1H3,(H,41,42)/t16-,17-,23?,26? JDAJQYNRMPEXFU-LRVXPCDCSA-N 382974 (1r,4r)-4-(9b-((4-fluorophenyl)sulfonyl)-5-methyl-7-(perfluoropropan-2-yl)-2,3,3a,4,5,9b-hexahydro-1H-pyrrolo[2,3-c]quinoline-3-carbonyl)cyclohexane-1-carboxylic acid::US10273259, Example 685::US10273259, Example 688::US10711020, Example 688 Nuclear receptor ROR-gamma [262-507] 28.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382974 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382974&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122669243 404852290 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931596 CCN1CC2N(CCC2(c2ccc(cc12)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1)C(=O)[C@H]1CC[C@@H](CC1)C(O)=O InChI=1S/C30H30F8N2O5S/c1-2-39-16-24-27(46(44,45)21-10-8-20(31)9-11-21,13-14-40(24)25(41)17-3-5-18(6-4-17)26(42)43)22-12-7-19(15-23(22)39)28(32,29(33,34)35)30(36,37)38/h7-12,15,17-18,24H,2-6,13-14,16H2,1H3,(H,42,43)/t17-,18-,24?,27? NXUBBEJNBJAHRO-VRSFHCCXSA-N 382975 US10273259, Example 686::US10273259, Example 687::US10711020, Example 687 Nuclear receptor ROR-gamma [262-507] 64.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382975 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382975&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678737 404852291 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931597 CCN1CC2N(CCC2(c2ccc(cc12)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1)C(=O)[C@H]1CC[C@@H](CC1)C(O)=O InChI=1S/C30H30F8N2O5S/c1-2-39-16-24-27(46(44,45)21-10-8-20(31)9-11-21,13-14-40(24)25(41)17-3-5-18(6-4-17)26(42)43)22-12-7-19(15-23(22)39)28(32,29(33,34)35)30(36,37)38/h7-12,15,17-18,24H,2-6,13-14,16H2,1H3,(H,42,43)/t17-,18-,24?,27? NXUBBEJNBJAHRO-VRSFHCCXSA-N 382975 US10273259, Example 686::US10273259, Example 687::US10711020, Example 687 Nuclear receptor ROR-gamma [262-507] 7301 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382975 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382975&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678737 404852291 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931598 CN1CC2N(CCC2(c2ccc(cc12)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1)C(=O)[C@H]1CC[C@@H](CC1)C(O)=O InChI=1S/C29H28F8N2O5S/c1-38-15-23-26(45(43,44)20-9-7-19(30)8-10-20,12-13-39(23)24(40)16-2-4-17(5-3-16)25(41)42)21-11-6-18(14-22(21)38)27(31,28(32,33)34)29(35,36)37/h6-11,14,16-17,23H,2-5,12-13,15H2,1H3,(H,41,42)/t16-,17-,23?,26? JDAJQYNRMPEXFU-LRVXPCDCSA-N 382974 (1r,4r)-4-(9b-((4-fluorophenyl)sulfonyl)-5-methyl-7-(perfluoropropan-2-yl)-2,3,3a,4,5,9b-hexahydro-1H-pyrrolo[2,3-c]quinoline-3-carbonyl)cyclohexane-1-carboxylic acid::US10273259, Example 685::US10273259, Example 688::US10711020, Example 688 Nuclear receptor ROR-gamma [262-507] 57.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382974 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382974&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122669243 404852290 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931599 CN1CC2N(CCC2(c2ccc(cc12)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1)C(=O)C12CCC(CC1)(CC2)C(O)=O InChI=1S/C31H30F8N2O5S/c1-40-17-23-28(47(45,46)20-5-3-19(32)4-6-20,21-7-2-18(16-22(21)40)29(33,30(34,35)36)31(37,38)39)14-15-41(23)24(42)26-8-11-27(12-9-26,13-10-26)25(43)44/h2-7,16,23H,8-15,17H2,1H3,(H,43,44) CERZXMFNZUFKEF-UHFFFAOYSA-N 382978 US10273259, Example 689::US10711020, Example 689 Nuclear receptor ROR-gamma [262-507] 40.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382978 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382978&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 132123584 404852292 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931600 CCN1CC2N(CCC2(c2ccc(cc12)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1)C(=O)C12CCC(CC1)(CC2)C(O)=O InChI=1S/C32H32F8N2O5S/c1-2-41-18-24-29(48(46,47)21-6-4-20(33)5-7-21,22-8-3-19(17-23(22)41)30(34,31(35,36)37)32(38,39)40)15-16-42(24)25(43)27-9-12-28(13-10-27,14-11-27)26(44)45/h3-8,17,24H,2,9-16,18H2,1H3,(H,44,45) WLOVMJJQDDUFPW-UHFFFAOYSA-N 382979 US10273259, Example 690::US10711020, Example 690 Nuclear receptor ROR-gamma [262-507] 44.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382979 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382979&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678872 404852293 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931601 CCCN1CC2N(CCC2(c2ccc(cc12)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1)C(=O)C12CCC(CC1)(CC2)C(O)=O InChI=1S/C33H34F8N2O5S/c1-2-16-42-19-25-30(49(47,48)22-6-4-21(34)5-7-22,23-8-3-20(18-24(23)42)31(35,32(36,37)38)33(39,40)41)15-17-43(25)26(44)28-9-12-29(13-10-28,14-11-28)27(45)46/h3-8,18,25H,2,9-17,19H2,1H3,(H,45,46) BVAKEDKWJDWPMS-UHFFFAOYSA-N 382980 US10273259, Example 691::US10711020, Example 691 Nuclear receptor ROR-gamma [262-507] 143 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382980 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382980&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679101 404852294 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931602 CCN1CC2N(CCC2(c2ccc(cc12)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1)C(=O)[C@H]1CC[C@@](C)(CC1)C(O)=O InChI=1S/C31H32F8N2O5S/c1-3-40-17-24-28(47(45,46)21-7-5-20(32)6-8-21,14-15-41(24)25(42)18-10-12-27(2,13-11-18)26(43)44)22-9-4-19(16-23(22)40)29(33,30(34,35)36)31(37,38)39/h4-9,16,18,24H,3,10-15,17H2,1-2H3,(H,43,44)/t18-,24?,27-,28? DSFYJEOIAKCMFQ-GLMFJJLTSA-N 382981 US10273259, Example 692::US10711020, Example 692 Nuclear receptor ROR-gamma [262-507] 4.00 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382981 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382981&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679110 404852295 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931603 CN1CC2N(CCC2(c2ccc(cc12)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1)C(=O)[C@@]1(F)CC[C@@H](CC1)C(O)=O InChI=1S/C29H27F9N2O5S/c1-39-15-22-26(46(44,45)19-5-3-18(30)4-6-19,12-13-40(22)24(43)25(31)10-8-16(9-11-25)23(41)42)20-7-2-17(14-21(20)39)27(32,28(33,34)35)29(36,37)38/h2-7,14,16,22H,8-13,15H2,1H3,(H,41,42)/t16-,22?,25+,26? BBBIQZWUOQKZRQ-VXBFRIGJSA-N 382982 US10273259, Example 693::US10711020, Example 693 Nuclear receptor ROR-gamma [262-507] 625 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382982 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382982&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679241 404852296 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931604 CN1CC2N(CCC2(c2ccc(cc12)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1)C(=O)[C@H]1CC[C@@](C)(CC1)C(O)=O InChI=1S/C30H30F8N2O5S/c1-26(25(42)43)11-9-17(10-12-26)24(41)40-14-13-27(46(44,45)20-6-4-19(31)5-7-20)21-8-3-18(15-22(21)39(2)16-23(27)40)28(32,29(33,34)35)30(36,37)38/h3-8,15,17,23H,9-14,16H2,1-2H3,(H,42,43)/t17-,23?,26-,27? SJWPZBFAJFYJBV-PYPIJRSMSA-N 382983 US10273259, Example 694::US10711020, Example 694 Nuclear receptor ROR-gamma [262-507] 217 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382983 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382983&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 132123592 404852297 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931605 CCCN1CC2N(CCC2(c2ccc(cc12)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1)C(=O)[C@@]1(F)CC[C@@H](CC1)C(O)=O InChI=1S/C31H31F9N2O5S/c1-2-14-41-17-24-28(48(46,47)21-6-4-20(32)5-7-21,13-15-42(24)26(45)27(33)11-9-18(10-12-27)25(43)44)22-8-3-19(16-23(22)41)29(34,30(35,36)37)31(38,39)40/h3-8,16,18,24H,2,9-15,17H2,1H3,(H,43,44)/t18-,24?,27+,28? JWKNRJRSZVICQO-UBOLYAJWSA-N 382984 US10273259, Example 695::US10711020, Example 695 Nuclear receptor ROR-gamma [262-507] 225 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382984 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382984&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679265 404852298 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931606 CCN1CC2N(CCC2(c2ccc(cc12)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1)C(=O)[C@@]1(F)CC[C@@H](CC1)C(O)=O InChI=1S/C30H29F9N2O5S/c1-2-40-16-23-27(47(45,46)20-6-4-19(31)5-7-20,13-14-41(23)25(44)26(32)11-9-17(10-12-26)24(42)43)21-8-3-18(15-22(21)40)28(33,29(34,35)36)30(37,38)39/h3-8,15,17,23H,2,9-14,16H2,1H3,(H,42,43)/t17-,23?,26+,27? ROAFSFHOECLXOK-MTOUGUCQSA-N 382985 US10273259, Example 696::US10711020, Example 696 Nuclear receptor ROR-gamma [262-507] 218 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382985 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382985&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678521 404852299 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931607 CCCN1CC2N(CCC2(c2ccc(cc12)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1)C(=O)[C@H]1CC[C@@H](CC1)C(O)=O InChI=1S/C31H32F8N2O5S/c1-2-14-40-17-25-28(47(45,46)22-10-8-21(32)9-11-22,13-15-41(25)26(42)18-3-5-19(6-4-18)27(43)44)23-12-7-20(16-24(23)40)29(33,30(34,35)36)31(37,38)39/h7-12,16,18-19,25H,2-6,13-15,17H2,1H3,(H,43,44)/t18-,19-,25?,28? BTJFMVNGAMYMNQ-XUNNZJKZSA-N 382986 US10273259, Example 697::US10711020, Example 697 Nuclear receptor ROR-gamma [262-507] 68.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382986 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382986&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679263 404852300 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931608 CCN1CC2N(CCC2(c2ccc(cc12)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1)C(=O)[C@@]1(C)CC[C@@H](CC1)C(O)=O InChI=1S/C31H32F8N2O5S/c1-3-40-17-24-28(47(45,46)21-7-5-20(32)6-8-21,14-15-41(24)26(44)27(2)12-10-18(11-13-27)25(42)43)22-9-4-19(16-23(22)40)29(33,30(34,35)36)31(37,38)39/h4-9,16,18,24H,3,10-15,17H2,1-2H3,(H,42,43)/t18-,24?,27-,28? BPOZKIUVNUVESR-GLMFJJLTSA-N 382987 US10273259, Example 698::US10711020, Example 698 Nuclear receptor ROR-gamma [262-507] 117 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382987 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382987&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678906 404852301 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931609 CN1CC2N(CCC2(c2ccc(cc12)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1)C(=O)[C@@]1(C)CC[C@@H](CC1)C(O)=O InChI=1S/C30H30F8N2O5S/c1-26(11-9-17(10-12-26)24(41)42)25(43)40-14-13-27(46(44,45)20-6-4-19(31)5-7-20)21-8-3-18(15-22(21)39(2)16-23(27)40)28(32,29(33,34)35)30(36,37)38/h3-8,15,17,23H,9-14,16H2,1-2H3,(H,41,42)/t17-,23?,26-,27? ZEGBCCPROSAOGK-PYPIJRSMSA-N 382988 US10273259, Example 699::US10711020, Example 699 Nuclear receptor ROR-gamma [262-507] 20.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382988 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382988&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678887 404852302 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931610 CCN1CC2N(CCC2(c2ccc(cc12)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccccc1)C(=O)[C@H]1CC[C@@H](CC1)C(O)=O InChI=1S/C30H31F7N2O5S/c1-2-38-17-24-27(45(43,44)21-6-4-3-5-7-21,14-15-39(24)25(40)18-8-10-19(11-9-18)26(41)42)22-13-12-20(16-23(22)38)28(31,29(32,33)34)30(35,36)37/h3-7,12-13,16,18-19,24H,2,8-11,14-15,17H2,1H3,(H,41,42)/t18-,19-,24?,27? DYGOBAFRTDAHKQ-QXIWJBPRSA-N 382989 US10273259, Example 700::US10711020, Example 700 Nuclear receptor ROR-gamma [262-507] 276 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382989 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382989&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678736 404852303 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931611 CCCN1CC2N(CCC2(c2ccc(cc12)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccccc1)C(=O)[C@H]1CC[C@@H](CC1)C(O)=O InChI=1S/C31H33F7N2O5S/c1-2-15-39-18-25-28(46(44,45)22-6-4-3-5-7-22,14-16-40(25)26(41)19-8-10-20(11-9-19)27(42)43)23-13-12-21(17-24(23)39)29(32,30(33,34)35)31(36,37)38/h3-7,12-13,17,19-20,25H,2,8-11,14-16,18H2,1H3,(H,42,43)/t19-,20-,25?,28? NBSMWOUOIMKCAB-IUKKCNNLSA-N 382990 US10273259, Example 701::US10711020, Example 701 Nuclear receptor ROR-gamma [262-507] 100.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382990 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382990&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678888 404852304 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931612 CN1CC2N(CCC2(c2ccc(cc12)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccccc1)C(=O)[C@H]1CC[C@@H](CC1)C(O)=O InChI=1S/C29H29F7N2O5S/c1-37-16-23-26(44(42,43)20-5-3-2-4-6-20,13-14-38(23)24(39)17-7-9-18(10-8-17)25(40)41)21-12-11-19(15-22(21)37)27(30,28(31,32)33)29(34,35)36/h2-6,11-12,15,17-18,23H,7-10,13-14,16H2,1H3,(H,40,41)/t17-,18-,23?,26? HJAHYEBMXFLUEJ-GIHSMNABSA-N 382991 US10273259, Example 702::US10711020, Example 702 Nuclear receptor ROR-gamma [262-507] 51.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382991 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382991&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679256 404852305 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931613 CN1CC2N(CCC2(c2ccc(cc12)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1cccc(F)c1)C(=O)[C@H]1CC[C@@H](CC1)C(O)=O InChI=1S/C29H28F8N2O5S/c1-38-15-23-26(45(43,44)20-4-2-3-19(30)14-20,11-12-39(23)24(40)16-5-7-17(8-6-16)25(41)42)21-10-9-18(13-22(21)38)27(31,28(32,33)34)29(35,36)37/h2-4,9-10,13-14,16-17,23H,5-8,11-12,15H2,1H3,(H,41,42)/t16-,17-,23?,26? GRGFWIALBLAFIO-LRVXPCDCSA-N 382992 US10273259, Example 703::US10273259, Example 714::US10711020, Example 714 Nuclear receptor ROR-gamma [262-507] 1883 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382992 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382992&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678895 404852306 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931614 CCN1CC2N(CCC2(c2ccc(cc12)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1cccc(F)c1)C(=O)[C@H]1CC[C@@H](CC1)C(O)=O InChI=1S/C30H30F8N2O5S/c1-2-39-16-24-27(46(44,45)21-5-3-4-20(31)15-21,12-13-40(24)25(41)17-6-8-18(9-7-17)26(42)43)22-11-10-19(14-23(22)39)28(32,29(33,34)35)30(36,37)38/h3-5,10-11,14-15,17-18,24H,2,6-9,12-13,16H2,1H3,(H,42,43)/t17-,18-,24?,27? NBNXACNXXIMYCS-VRSFHCCXSA-N 382993 US10273259, Example 704::US10273259, Example 713::US10711020, Example 713 Nuclear receptor ROR-gamma [262-507] 2125 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382993 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382993&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678902 404852307 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931615 CN1[C@@H](C[C@H](F)C1=O)C(=O)N1CCC2(C1CN(C)c1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1cccc(F)c1 InChI=1S/C27H24F9N3O4S/c1-37-13-21-24(44(42,43)16-5-3-4-15(28)11-16,8-9-39(21)23(41)20-12-18(29)22(40)38(20)2)17-7-6-14(10-19(17)37)25(30,26(31,32)33)27(34,35)36/h3-7,10-11,18,20-21H,8-9,12-13H2,1-2H3/t18-,20-,21?,24?/m0/s1 RRXIBUSZXQWSNN-ULJIEDDMSA-N 382994 US10273259, Example 705::US10273259, Example 716::US10711020, Example 716 Nuclear receptor ROR-gamma [262-507] 1470 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382994 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382994&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 145995609 404852308 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931616 CCN1CC2N(CCC2(c2ccc(cc12)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccccc1)C(=O)C1CCS(=O)(=O)CC1 InChI=1S/C28H29F7N2O5S2/c1-2-36-17-23-25(44(41,42)20-6-4-3-5-7-20,12-13-37(23)24(38)18-10-14-43(39,40)15-11-18)21-9-8-19(16-22(21)36)26(29,27(30,31)32)28(33,34)35/h3-9,16,18,23H,2,10-15,17H2,1H3 DYLPRTXNTCIXCH-UHFFFAOYSA-N 382995 US10273259, Example 706::US10711020, Example 706 Nuclear receptor ROR-gamma [262-507] 161 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382995 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382995&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678854 404852309 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931617 CN1CC2N(CCC2(c2ccc(cc12)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccccc1)C(=O)C1CCS(=O)(=O)CC1 InChI=1S/C27H27F7N2O5S2/c1-35-16-22-24(43(40,41)19-5-3-2-4-6-19,11-12-36(22)23(37)17-9-13-42(38,39)14-10-17)20-8-7-18(15-21(20)35)25(28,26(29,30)31)27(32,33)34/h2-8,15,17,22H,9-14,16H2,1H3 SLRWDASWAUKALJ-UHFFFAOYSA-N 382996 US10273259, Example 707::US10711020, Example 707 Nuclear receptor ROR-gamma [262-507] 43.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382996 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382996&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679252 404852310 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931618 CN1CC2N(CCC2(c2ccc(cc12)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1)C(=O)C1CCS(=O)(=O)CC1 InChI=1S/C27H26F8N2O5S2/c1-36-15-22-24(44(41,42)19-5-3-18(28)4-6-19,10-11-37(22)23(38)16-8-12-43(39,40)13-9-16)20-7-2-17(14-21(20)36)25(29,26(30,31)32)27(33,34)35/h2-7,14,16,22H,8-13,15H2,1H3 JFDWMQCQKZSUOY-UHFFFAOYSA-N 382997 US10273259, Example 708::US10711020, Example 708 Nuclear receptor ROR-gamma [262-507] 15.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382997 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382997&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679192 404852311 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931619 CCN1CC2N(CCC2(c2ccc(cc12)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1)C(=O)C1CCS(=O)(=O)CC1 InChI=1S/C28H28F8N2O5S2/c1-2-37-16-23-25(45(42,43)20-6-4-19(29)5-7-20,11-12-38(23)24(39)17-9-13-44(40,41)14-10-17)21-8-3-18(15-22(21)37)26(30,27(31,32)33)28(34,35)36/h3-8,15,17,23H,2,9-14,16H2,1H3 NMTKWMICLMJXTR-UHFFFAOYSA-N 382998 US10273259, Example 709::US10711020, Example 709 Nuclear receptor ROR-gamma [262-507] 31.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382998 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382998&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678850 404852312 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931620 CN1CC2N(CCC2(c2ccc(cc12)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1cccc(F)c1)C(=O)C1CCS(=O)(=O)CC1 InChI=1S/C27H26F8N2O5S2/c1-36-15-22-24(44(41,42)19-4-2-3-18(28)14-19,9-10-37(22)23(38)16-7-11-43(39,40)12-8-16)20-6-5-17(13-21(20)36)25(29,26(30,31)32)27(33,34)35/h2-6,13-14,16,22H,7-12,15H2,1H3 QDMRCTNBBYEWGX-UHFFFAOYSA-N 382999 US10273259, Example 710::US10711020, Example 710 Nuclear receptor ROR-gamma [262-507] 30.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382999 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382999&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679056 404852313 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931621 CCN1CC2N(CCC2(c2ccc(cc12)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccccc1)C(=O)[C@@]1(F)CC[C@@H](CC1)C(O)=O InChI=1S/C30H30F8N2O5S/c1-2-39-17-23-27(46(44,45)20-6-4-3-5-7-20,14-15-40(23)25(43)26(31)12-10-18(11-13-26)24(41)42)21-9-8-19(16-22(21)39)28(32,29(33,34)35)30(36,37)38/h3-9,16,18,23H,2,10-15,17H2,1H3,(H,41,42)/t18-,23?,26+,27? HFJJPNSOTVSZPX-MJALUPOVSA-N 383000 US10273259, Example 711::US10711020, Example 711 Nuclear receptor ROR-gamma [262-507] 26.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383000 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383000&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679272 404852314 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931622 CN1CC2N(CCC2(c2ccc(cc12)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccccc1)C(=O)[C@@]1(F)CC[C@@H](CC1)C(O)=O InChI=1S/C29H28F8N2O5S/c1-38-16-22-26(45(43,44)19-5-3-2-4-6-19,13-14-39(22)24(42)25(30)11-9-17(10-12-25)23(40)41)20-8-7-18(15-21(20)38)27(31,28(32,33)34)29(35,36)37/h2-8,15,17,22H,9-14,16H2,1H3,(H,40,41)/t17-,22?,25+,26? LDMASGNBXNKNES-ZZDDDDRDSA-N 383001 US10273259, Example 712::US10711020, Example 712 Nuclear receptor ROR-gamma [262-507] 27.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383001 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383001&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678750 404852315 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931623 CCN1CC2N(CCC2(c2ccc(cc12)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1cccc(F)c1)C(=O)[C@H]1CC[C@@H](CC1)C(O)=O InChI=1S/C30H30F8N2O5S/c1-2-39-16-24-27(46(44,45)21-5-3-4-20(31)15-21,12-13-40(24)25(41)17-6-8-18(9-7-17)26(42)43)22-11-10-19(14-23(22)39)28(32,29(33,34)35)30(36,37)38/h3-5,10-11,14-15,17-18,24H,2,6-9,12-13,16H2,1H3,(H,42,43)/t17-,18-,24?,27? NBNXACNXXIMYCS-VRSFHCCXSA-N 382993 US10273259, Example 704::US10273259, Example 713::US10711020, Example 713 Nuclear receptor ROR-gamma [262-507] 48.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382993 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382993&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678902 404852307 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931624 CN1CC2N(CCC2(c2ccc(cc12)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1cccc(F)c1)C(=O)[C@H]1CC[C@@H](CC1)C(O)=O InChI=1S/C29H28F8N2O5S/c1-38-15-23-26(45(43,44)20-4-2-3-19(30)14-20,11-12-39(23)24(40)16-5-7-17(8-6-16)25(41)42)21-10-9-18(13-22(21)38)27(31,28(32,33)34)29(35,36)37/h2-4,9-10,13-14,16-17,23H,5-8,11-12,15H2,1H3,(H,41,42)/t16-,17-,23?,26? GRGFWIALBLAFIO-LRVXPCDCSA-N 382992 US10273259, Example 703::US10273259, Example 714::US10711020, Example 714 Nuclear receptor ROR-gamma [262-507] 82.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382992 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382992&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678895 404852306 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931625 CN1CC2N(CCC2(c2ccc(cc12)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1cccc(F)c1)C(=O)[C@@]1(F)CC[C@@H](CC1)C(O)=O InChI=1S/C29H27F9N2O5S/c1-39-15-22-26(46(44,45)19-4-2-3-18(30)14-19,11-12-40(22)24(43)25(31)9-7-16(8-10-25)23(41)42)20-6-5-17(13-21(20)39)27(32,28(33,34)35)29(36,37)38/h2-6,13-14,16,22H,7-12,15H2,1H3,(H,41,42)/t16-,22?,25+,26? FMNWOCHOXUNIRW-VXBFRIGJSA-N 383004 US10273259, Example 715::US10711020, Example 715 Nuclear receptor ROR-gamma [262-507] 30.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383004 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383004&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679128 404852316 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931626 CN1[C@@H](C[C@H](F)C1=O)C(=O)N1CCC2(C1CN(C)c1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1cccc(F)c1 InChI=1S/C27H24F9N3O4S/c1-37-13-21-24(44(42,43)16-5-3-4-15(28)11-16,8-9-39(21)23(41)20-12-18(29)22(40)38(20)2)17-7-6-14(10-19(17)37)25(30,26(31,32)33)27(34,35)36/h3-7,10-11,18,20-21H,8-9,12-13H2,1-2H3/t18-,20-,21?,24?/m0/s1 RRXIBUSZXQWSNN-ULJIEDDMSA-N 382994 US10273259, Example 705::US10273259, Example 716::US10711020, Example 716 Nuclear receptor ROR-gamma [262-507] 30.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382994 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382994&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 145995609 404852308 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931627 CCN1CC2N(CCC2(c2ccc(cc12)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1)C(=O)C1(O)CCS(=O)(=O)CC1 InChI=1S/C28H28F8N2O6S2/c1-2-37-16-22-25(46(43,44)19-6-4-18(29)5-7-19,9-12-38(22)23(39)24(40)10-13-45(41,42)14-11-24)20-8-3-17(15-21(20)37)26(30,27(31,32)33)28(34,35)36/h3-8,15,22,40H,2,9-14,16H2,1H3 WEVAOQONOCEOCA-UHFFFAOYSA-N 383006 US10273259, Example 717::US10711020, Example 717 Nuclear receptor ROR-gamma [262-507] 70.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383006 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383006&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679151 404852317 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931628 CN1CC2N(CCC2(c2ccc(cc12)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(Cl)cc1)C(=O)[C@@]1(F)CC[C@@H](CC1)C(O)=O InChI=1S/C29H27ClF8N2O5S/c1-39-15-22-26(46(44,45)19-5-3-18(30)4-6-19,12-13-40(22)24(43)25(31)10-8-16(9-11-25)23(41)42)20-7-2-17(14-21(20)39)27(32,28(33,34)35)29(36,37)38/h2-7,14,16,22H,8-13,15H2,1H3,(H,41,42)/t16-,22?,25+,26? XAVVESOTQYRIKJ-VXBFRIGJSA-N 383007 US10273259, Example 718::US10711020, Example 718 Nuclear receptor ROR-gamma [262-507] 76.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383007 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383007&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678771 404852318 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931629 CCN1CC2N(CCC2(c2ccc(cc12)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(Cl)cc1)C(=O)[C@H]1CC[C@@H](CC1)C(O)=O InChI=1S/C30H30ClF7N2O5S/c1-2-39-16-24-27(46(44,45)21-10-8-20(31)9-11-21,13-14-40(24)25(41)17-3-5-18(6-4-17)26(42)43)22-12-7-19(15-23(22)39)28(32,29(33,34)35)30(36,37)38/h7-12,15,17-18,24H,2-6,13-14,16H2,1H3,(H,42,43)/t17-,18-,24?,27? MHZASLHOGPGBMN-VRSFHCCXSA-N 383008 US10273259, Example 719::US10711020, Example 719 Nuclear receptor ROR-gamma [262-507] 295 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383008 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383008&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679134 404852319 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931630 CCN1CC2N(CCC2(c2ccc(cc12)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(Cl)cc1)C(=O)C1CCS(=O)(=O)CC1 InChI=1S/C28H28ClF7N2O5S2/c1-2-37-16-23-25(45(42,43)20-6-4-19(29)5-7-20,11-12-38(23)24(39)17-9-13-44(40,41)14-10-17)21-8-3-18(15-22(21)37)26(30,27(31,32)33)28(34,35)36/h3-8,15,17,23H,2,9-14,16H2,1H3 WCOFXTZWIRUVBM-UHFFFAOYSA-N 383009 US10273259, Example 720::US10711020, Example 720 Nuclear receptor ROR-gamma [262-507] 428 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383009 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383009&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678833 404852320 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931631 NC(=O)CN1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C23H20F8N2O3S/c24-15-3-5-16(6-4-15)37(35,36)20-9-10-33(12-19(32)34)18(20)8-1-13-11-14(2-7-17(13)20)21(25,22(26,27)28)23(29,30)31/h2-7,11,18H,1,8-10,12H2,(H2,32,34)/t18-,20-/m1/s1 MVZQNVFLKJWGAB-UYAOXDASSA-N 383010 2-((3aR,9bR)-9b-((4-fluorophenyl)sulfonyl)-7-(perfluoropropan-2-yl)-1,2,3a,4,5,9b-hexahydro-3H-benzo[e]indol-3-yl)acetamide::US10273259, Example 721::US10711020, Example 721 Nuclear receptor ROR-gamma [262-507] 52.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383010 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383010&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122669065 404852321 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931632 CC(N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1)C(N)=O InChI=1S/C24H22F8N2O3S/c1-13(20(33)35)34-11-10-21(38(36,37)17-6-4-16(25)5-7-17)18-8-3-15(12-14(18)2-9-19(21)34)22(26,23(27,28)29)24(30,31)32/h3-8,12-13,19H,2,9-11H2,1H3,(H2,33,35)/t13?,19-,21-/m1/s1 ASBWXSYJMRZXMQ-BTSGLNRLSA-N 383011 (RS)-2-((3aR,9bR)-9b-((4-fluorophenyl)sulfonyl)-7-(perfluoropropan-2-yl)-,2,3a,4,5,9b-hexahydro-3H-benzo[e]indol-3-yl)propanamide::US10273259, Example 722::US10711020, Example 722 Nuclear receptor ROR-gamma [262-507] 73.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383011 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383011&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122669125 404852322 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931633 CNC(=O)CN1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C24H22F8N2O3S/c1-33-20(35)13-34-11-10-21(38(36,37)17-6-4-16(25)5-7-17)18-8-3-15(12-14(18)2-9-19(21)34)22(26,23(27,28)29)24(30,31)32/h3-8,12,19H,2,9-11,13H2,1H3,(H,33,35)/t19-,21-/m1/s1 NOPYNBZXIYAOSY-TZIWHRDSSA-N 383012 2-((3aR,9bR)-9b-((4-fluorophenyl)sulfonyl)-7-(perfluoropropan-2-yl)-1,2,3a,4,5,9b-hexahydro-3H-benzo[e]indol-3-yl)-N-(methyl-d3)acetamide::US10273259, Example 723::US10273259, Example 724::US10273259, Example 752::US10711020, Example 752 Nuclear receptor ROR-gamma [262-507] 136 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383012 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383012&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679257 404852323 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931634 CNC(=O)CN1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C24H22F8N2O3S/c1-33-20(35)13-34-11-10-21(38(36,37)17-6-4-16(25)5-7-17)18-8-3-15(12-14(18)2-9-19(21)34)22(26,23(27,28)29)24(30,31)32/h3-8,12,19H,2,9-11,13H2,1H3,(H,33,35)/t19-,21-/m1/s1 NOPYNBZXIYAOSY-TZIWHRDSSA-N 383012 2-((3aR,9bR)-9b-((4-fluorophenyl)sulfonyl)-7-(perfluoropropan-2-yl)-1,2,3a,4,5,9b-hexahydro-3H-benzo[e]indol-3-yl)-N-(methyl-d3)acetamide::US10273259, Example 723::US10273259, Example 724::US10273259, Example 752::US10711020, Example 752 Nuclear receptor ROR-gamma [262-507] 142 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383012 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383012&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679257 404852323 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931635 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN(CC(=O)N3CCOCC3)[C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F InChI=1S/C27H26F8N2O4S/c28-19-3-5-20(6-4-19)42(39,40)24-9-10-37(16-23(38)36-11-13-41-14-12-36)22(24)8-1-17-15-18(2-7-21(17)24)25(29,26(30,31)32)27(33,34)35/h2-7,15,22H,1,8-14,16H2/t22-,24-/m1/s1 IDHGOYVHCYWYON-ISKFKSNPSA-N 383014 US10273259, Example 725::US10711020, Example 725 Nuclear receptor ROR-gamma [262-507] 95.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383014 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383014&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679067 404852324 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931636 CCOC(=O)Cc1csc(NC(=O)CN2CC[C@@]3([C@H]2CCc2cc(ccc32)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c2ccc(F)cc2)n1 InChI=1S/C30H27F8N3O5S2/c1-2-46-25(43)14-20-16-47-26(39-20)40-24(42)15-41-12-11-27(48(44,45)21-7-5-19(31)6-8-21)22-9-4-18(13-17(22)3-10-23(27)41)28(32,29(33,34)35)30(36,37)38/h4-9,13,16,23H,2-3,10-12,14-15H2,1H3,(H,39,40,42)/t23-,27-/m1/s1 KQTAMRQPWNHHKW-YIXXDRMTSA-N 383015 US10273259, Example 726::US10711020, Example 726 Nuclear receptor ROR-gamma [262-507] 114 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383015 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383015&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679275 404852325 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931637 OC(=O)Cc1csc(NC(=O)CN2CC[C@@]3([C@H]2CCc2cc(ccc32)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c2ccc(F)cc2)n1 InChI=1S/C28H23F8N3O5S2/c29-17-3-5-19(6-4-17)46(43,44)25-9-10-39(13-22(40)38-24-37-18(14-45-24)12-23(41)42)21(25)8-1-15-11-16(2-7-20(15)25)26(30,27(31,32)33)28(34,35)36/h2-7,11,14,21H,1,8-10,12-13H2,(H,41,42)(H,37,38,40)/t21-,25-/m1/s1 VKXMKEOKORZLRT-PXDATVDWSA-N 383016 US10273259, Example 727::US10711020, Example 727 Nuclear receptor ROR-gamma [262-507] 77.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383016 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383016&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679246 404852326 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931638 CN(C)C(=O)CN1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C25H24F8N2O3S/c1-34(2)21(36)14-35-12-11-22(39(37,38)18-7-5-17(26)6-8-18)19-9-4-16(13-15(19)3-10-20(22)35)23(27,24(28,29)30)25(31,32)33/h4-9,13,20H,3,10-12,14H2,1-2H3/t20-,22-/m1/s1 BVWDTPOUDOUZHX-IFMALSPDSA-N 383017 US10273259, Example 728::US10711020, Example 728 Nuclear receptor ROR-gamma [262-507] 77.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383017 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383017&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678773 404852327 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931639 NC(=O)CCN1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C24H22F8N2O3S/c25-16-3-5-17(6-4-16)38(36,37)21-10-12-34(11-9-20(33)35)19(21)8-1-14-13-15(2-7-18(14)21)22(26,23(27,28)29)24(30,31)32/h2-7,13,19H,1,8-12H2,(H2,33,35)/t19-,21-/m1/s1 ULYUEKJPYPRTPZ-TZIWHRDSSA-N 383018 US10273259, Example 729::US10711020, Example 729 Nuclear receptor ROR-gamma [262-507] 52.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383018 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383018&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679266 404852328 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931640 OC(=O)CN1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C23H19F8NO4S/c24-15-3-5-16(6-4-15)37(35,36)20-9-10-32(12-19(33)34)18(20)8-1-13-11-14(2-7-17(13)20)21(25,22(26,27)28)23(29,30)31/h2-7,11,18H,1,8-10,12H2,(H,33,34)/t18-,20-/m1/s1 QZDXZFOARXONJV-UYAOXDASSA-N 383019 US10273259, Example 730::US10711020, Example 730 Nuclear receptor ROR-gamma [262-507] 82.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383019 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383019&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122669192 404852329 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931641 OC(=O)CCCCCN1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C27H27F8NO4S/c28-19-7-9-20(10-8-19)41(39,40)24-13-15-36(14-3-1-2-4-23(37)38)22(24)12-5-17-16-18(6-11-21(17)24)25(29,26(30,31)32)27(33,34)35/h6-11,16,22H,1-5,12-15H2,(H,37,38)/t22-,24-/m1/s1 SUGZRDDXWKPQLH-ISKFKSNPSA-N 383020 US10273259, Example 731::US10711020, Example 731 Nuclear receptor ROR-gamma [262-507] 119 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383020 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383020&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679080 404852330 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931642 OC(=O)CCCN1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C25H23F8NO4S/c26-17-5-7-18(8-6-17)39(37,38)22-11-13-34(12-1-2-21(35)36)20(22)10-3-15-14-16(4-9-19(15)22)23(27,24(28,29)30)25(31,32)33/h4-9,14,20H,1-3,10-13H2,(H,35,36)/t20-,22-/m1/s1 UTFSZTSRHCOILN-IFMALSPDSA-N 383021 US10273259, Example 732::US10711020, Example 732 Nuclear receptor ROR-gamma [262-507] 44.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383021 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383021&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678891 404852331 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931643 OC(=O)CCN1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C24H21F8NO4S/c25-16-3-5-17(6-4-16)38(36,37)21-10-12-33(11-9-20(34)35)19(21)8-1-14-13-15(2-7-18(14)21)22(26,23(27,28)29)24(30,31)32/h2-7,13,19H,1,8-12H2,(H,34,35)/t19-,21-/m1/s1 PPHLYBDXZSLEKJ-TZIWHRDSSA-N 383022 US10273259, Example 733::US10711020, Example 733 Nuclear receptor ROR-gamma [262-507] 332 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383022 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383022&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679088 404852332 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931644 OC(=O)CCCCN1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C26H25F8NO4S/c27-18-6-8-19(9-7-18)40(38,39)23-12-14-35(13-2-1-3-22(36)37)21(23)11-4-16-15-17(5-10-20(16)23)24(28,25(29,30)31)26(32,33)34/h5-10,15,21H,1-4,11-14H2,(H,36,37)/t21-,23-/m1/s1 OKYCMYXKRFRHQW-FYYLOGMGSA-N 383023 US10273259, Example 734::US10711020, Example 734 Nuclear receptor ROR-gamma [262-507] 131 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383023 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383023&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679154 404852333 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931645 CCOC(=O)C(F)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(O)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C25H23F8NO5S/c1-2-39-21(35)20(27)34-12-11-22(40(37,38)17-7-5-16(26)6-8-17)18-9-4-15(13-14(18)3-10-19(22)34)23(36,24(28,29)30)25(31,32)33/h4-9,13,19-20,36H,2-3,10-12H2,1H3/t19-,20?,22-/m1/s1 AUXBDTLQRLEZGQ-ZAWSQKNBSA-N 453770 US10711020, Example 735 Nuclear receptor ROR-gamma [262-507] 103 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=453770 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=453770&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 155883656 440969657 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931646 CCNC(=O)CN1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C25H24F8N2O3S/c1-2-34-21(36)14-35-12-11-22(39(37,38)18-7-5-17(26)6-8-18)19-9-4-16(13-15(19)3-10-20(22)35)23(27,24(28,29)30)25(31,32)33/h4-9,13,20H,2-3,10-12,14H2,1H3,(H,34,36)/t20-,22-/m1/s1 SVQFZYUQQHXZGD-IFMALSPDSA-N 383025 US10273259, Example 736::US10711020, Example 736 Nuclear receptor ROR-gamma [262-507] 78.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383025 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383025&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679124 404852335 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931647 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN(C3CCN(Cc4ccccc4)C3=O)[C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F InChI=1S/C32H28F8N2O3S/c33-23-8-10-24(11-9-23)46(44,45)29-15-17-42(26-14-16-41(28(26)43)19-20-4-2-1-3-5-20)27(29)13-6-21-18-22(7-12-25(21)29)30(34,31(35,36)37)32(38,39)40/h1-5,7-12,18,26-27H,6,13-17,19H2/t26?,27-,29-/m1/s1 ICLZCKRMOVORRX-GGMYVPERSA-N 383026 US10273259, Example 737::US10273259, Example 738::US10711020, Example 738 Nuclear receptor ROR-gamma [262-507] 368 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383026 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383026&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678768 404852336 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931648 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN(C3CCN(Cc4ccccc4)C3=O)[C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F InChI=1S/C32H28F8N2O3S/c33-23-8-10-24(11-9-23)46(44,45)29-15-17-42(26-14-16-41(28(26)43)19-20-4-2-1-3-5-20)27(29)13-6-21-18-22(7-12-25(21)29)30(34,31(35,36)37)32(38,39)40/h1-5,7-12,18,26-27H,6,13-17,19H2/t26?,27-,29-/m1/s1 ICLZCKRMOVORRX-GGMYVPERSA-N 383026 US10273259, Example 737::US10273259, Example 738::US10711020, Example 738 Nuclear receptor ROR-gamma [262-507] 139 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383026 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383026&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678768 404852336 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931649 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN(C3CCNC3=O)[C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F InChI=1S/C25H22F8N2O3S/c26-16-3-5-17(6-4-16)39(37,38)22-10-12-35(19-9-11-34-21(19)36)20(22)8-1-14-13-15(2-7-18(14)22)23(27,24(28,29)30)25(31,32)33/h2-7,13,19-20H,1,8-12H2,(H,34,36)/t19?,20-,22-/m1/s1 VLDIWJBHEQTZRM-NQUCAWMESA-N 383028 US10273259, Example 739::US10711020, Example 739 Nuclear receptor ROR-gamma [262-507] 196 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383028 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383028&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678761 404852337 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931650 OC(=O)c1ccc2C(CCc2c1)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C31H25F8NO4S/c32-21-5-7-22(8-6-21)45(43,44)28-13-14-40(25-11-2-17-15-19(27(41)42)1-9-23(17)25)26(28)12-3-18-16-20(4-10-24(18)28)29(33,30(34,35)36)31(37,38)39/h1,4-10,15-16,25-26H,2-3,11-14H2,(H,41,42)/t25?,26-,28-/m1/s1 PICYUUMZGMTICO-BODSDZGOSA-N 383029 US10273259, Example 740::US10273259, Example 741::US10711020, Example 741 Nuclear receptor ROR-gamma [262-507] 561 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383029 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383029&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678778 404852338 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931651 OC(=O)c1ccc2C(CCc2c1)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C31H25F8NO4S/c32-21-5-7-22(8-6-21)45(43,44)28-13-14-40(25-11-2-17-15-19(27(41)42)1-9-23(17)25)26(28)12-3-18-16-20(4-10-24(18)28)29(33,30(34,35)36)31(37,38)39/h1,4-10,15-16,25-26H,2-3,11-14H2,(H,41,42)/t25?,26-,28-/m1/s1 PICYUUMZGMTICO-BODSDZGOSA-N 383029 US10273259, Example 740::US10273259, Example 741::US10711020, Example 741 Nuclear receptor ROR-gamma [262-507] 284 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383029 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383029&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678778 404852338 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931652 CNC(=O)CN1CCC2(C1COc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C23H20F8N2O4S/c1-32-19(34)11-33-9-8-20(38(35,36)15-5-3-14(24)4-6-15)16-7-2-13(10-17(16)37-12-18(20)33)21(25,22(26,27)28)23(29,30)31/h2-7,10,18H,8-9,11-12H2,1H3,(H,32,34) QQAIEKOEHZRWSN-UHFFFAOYSA-N 383031 US10273259, Example 742::US10711020, Example 742 Nuclear receptor ROR-gamma [262-507] 64.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383031 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383031&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679230 404852339 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931653 NC(=O)CN1CCC2(C1COc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C22H18F8N2O4S/c23-13-2-4-14(5-3-13)37(34,35)19-7-8-32(10-18(31)33)17(19)11-36-16-9-12(1-6-15(16)19)20(24,21(25,26)27)22(28,29)30/h1-6,9,17H,7-8,10-11H2,(H2,31,33) LCXOZLWBOIWNGY-UHFFFAOYSA-N 383032 US10273259, Example 743::US10711020, Example 743 Nuclear receptor ROR-gamma [262-507] 84.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383032 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383032&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678781 404852340 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931654 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN(CC(=O)NCC(F)(F)F)[C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F InChI=1S/C25H21F11N2O3S/c26-16-3-5-17(6-4-16)42(40,41)21-9-10-38(12-20(39)37-13-22(27,28)29)19(21)8-1-14-11-15(2-7-18(14)21)23(30,24(31,32)33)25(34,35)36/h2-7,11,19H,1,8-10,12-13H2,(H,37,39)/t19-,21-/m1/s1 SBWYIQHQFWIWNP-TZIWHRDSSA-N 383033 US10273259, Example 744::US10711020, Example 744 Nuclear receptor ROR-gamma [262-507] 84.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383033 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383033&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678916 404852341 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931655 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN(CC(=O)NC3CC3)[C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F InChI=1S/C26H24F8N2O3S/c27-17-3-7-19(8-4-17)40(38,39)23-11-12-36(14-22(37)35-18-5-6-18)21(23)10-1-15-13-16(2-9-20(15)23)24(28,25(29,30)31)26(32,33)34/h2-4,7-9,13,18,21H,1,5-6,10-12,14H2,(H,35,37)/t21-,23-/m1/s1 NQPNRPOIPDEHRU-FYYLOGMGSA-N 383034 US10273259, Example 745::US10711020, Example 745 Nuclear receptor ROR-gamma [262-507] 150 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383034 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383034&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678919 404852342 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931656 CNC(=O)CCN1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C25H24F8N2O3S/c1-34-21(36)10-12-35-13-11-22(39(37,38)18-6-4-17(26)5-7-18)19-8-3-16(14-15(19)2-9-20(22)35)23(27,24(28,29)30)25(31,32)33/h3-8,14,20H,2,9-13H2,1H3,(H,34,36)/t20-,22-/m1/s1 YSFRVCIDCHLBKN-IFMALSPDSA-N 383035 US10273259, Example 746::US10711020, Example 746 Nuclear receptor ROR-gamma [262-507] 147 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383035 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383035&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 145995610 404852343 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931657 CNC(=O)C(N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1)c1ccccc1 InChI=1S/C30H26F8N2O3S/c1-39-26(41)25(18-5-3-2-4-6-18)40-16-15-27(44(42,43)22-11-9-21(31)10-12-22)23-13-8-20(17-19(23)7-14-24(27)40)28(32,29(33,34)35)30(36,37)38/h2-6,8-13,17,24-25H,7,14-16H2,1H3,(H,39,41)/t24-,25?,27-/m1/s1 AFNKQJGZJNATFF-PTYBVJFYSA-N 383036 US10273259, Example 747::US10273259, Example 748::US10711020, Example 748 Nuclear receptor ROR-gamma [262-507] 300 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383036 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383036&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 145995611 404852344 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931658 CNC(=O)C(N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1)c1ccccc1 InChI=1S/C30H26F8N2O3S/c1-39-26(41)25(18-5-3-2-4-6-18)40-16-15-27(44(42,43)22-11-9-21(31)10-12-22)23-13-8-20(17-19(23)7-14-24(27)40)28(32,29(33,34)35)30(36,37)38/h2-6,8-13,17,24-25H,7,14-16H2,1H3,(H,39,41)/t24-,25?,27-/m1/s1 AFNKQJGZJNATFF-PTYBVJFYSA-N 383036 US10273259, Example 747::US10273259, Example 748::US10711020, Example 748 Nuclear receptor ROR-gamma [262-507] 542 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383036 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383036&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 145995611 404852344 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931659 CNC(=O)C(C)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C25H24F8N2O3S/c1-14(21(36)34-2)35-12-11-22(39(37,38)18-7-5-17(26)6-8-18)19-9-4-16(13-15(19)3-10-20(22)35)23(27,24(28,29)30)25(31,32)33/h4-9,13-14,20H,3,10-12H2,1-2H3,(H,34,36)/t14?,20-,22-/m1/s1 VZUREBOIBVKHIF-FRPDIZBGSA-N 383038 US10273259, Example 749::US10273259, Example 750::US10711020, Example 750 Nuclear receptor ROR-gamma [262-507] 138 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383038 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383038&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 145995612 404852345 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931660 CNC(=O)C(C)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C25H24F8N2O3S/c1-14(21(36)34-2)35-12-11-22(39(37,38)18-7-5-17(26)6-8-18)19-9-4-16(13-15(19)3-10-20(22)35)23(27,24(28,29)30)25(31,32)33/h4-9,13-14,20H,3,10-12H2,1-2H3,(H,34,36)/t14?,20-,22-/m1/s1 VZUREBOIBVKHIF-FRPDIZBGSA-N 383038 US10273259, Example 749::US10273259, Example 750::US10711020, Example 750 Nuclear receptor ROR-gamma [262-507] 99.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383038 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383038&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 145995612 404852345 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931661 CNC(=O)C(F)(F)CN1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C25H22F10N2O3S/c1-36-20(38)22(27,28)13-37-11-10-21(41(39,40)17-6-4-16(26)5-7-17)18-8-3-15(12-14(18)2-9-19(21)37)23(29,24(30,31)32)25(33,34)35/h3-8,12,19H,2,9-11,13H2,1H3,(H,36,38)/t19-,21-/m1/s1 UOVMMNMKAUMCFP-TZIWHRDSSA-N 383040 US10273259, Example 751::US10711020, Example 751 Nuclear receptor ROR-gamma [262-507] 70.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383040 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383040&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 145995613 404852346 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931662 CNC(=O)CN1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C24H22F8N2O3S/c1-33-20(35)13-34-11-10-21(38(36,37)17-6-4-16(25)5-7-17)18-8-3-15(12-14(18)2-9-19(21)34)22(26,23(27,28)29)24(30,31)32/h3-8,12,19H,2,9-11,13H2,1H3,(H,33,35)/t19-,21-/m1/s1 NOPYNBZXIYAOSY-TZIWHRDSSA-N 383012 2-((3aR,9bR)-9b-((4-fluorophenyl)sulfonyl)-7-(perfluoropropan-2-yl)-1,2,3a,4,5,9b-hexahydro-3H-benzo[e]indol-3-yl)-N-(methyl-d3)acetamide::US10273259, Example 723::US10273259, Example 724::US10273259, Example 752::US10711020, Example 752 Nuclear receptor ROR-gamma [262-507] 72.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383012 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383012&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679257 404852323 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931663 CCC(N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1)C(=O)NC InChI=1S/C26H26F8N2O3S/c1-3-20(22(37)35-2)36-13-12-23(40(38,39)18-8-6-17(27)7-9-18)19-10-5-16(14-15(19)4-11-21(23)36)24(28,25(29,30)31)26(32,33)34/h5-10,14,20-21H,3-4,11-13H2,1-2H3,(H,35,37)/t20?,21-,23-/m1/s1 BLBQMNISGHZKLE-CQQDSARBSA-N 383042 US10273259, Example 753::US10273259, Example 754::US10711020, Example 754 Nuclear receptor ROR-gamma [262-507] 34.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383042 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383042&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 145995614 404852347 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931664 CCC(N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1)C(=O)NC InChI=1S/C26H26F8N2O3S/c1-3-20(22(37)35-2)36-13-12-23(40(38,39)18-8-6-17(27)7-9-18)19-10-5-16(14-15(19)4-11-21(23)36)24(28,25(29,30)31)26(32,33)34/h5-10,14,20-21H,3-4,11-13H2,1-2H3,(H,35,37)/t20?,21-,23-/m1/s1 BLBQMNISGHZKLE-CQQDSARBSA-N 383042 US10273259, Example 753::US10273259, Example 754::US10711020, Example 754 Nuclear receptor ROR-gamma [262-507] 75.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383042 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383042&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 145995614 404852347 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931665 OC(=O)c1ccc(CN2CC[C@@]3([C@H]2CCc2cc(ccc32)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c2ccc(F)cc2)c(F)c1 InChI=1S/C29H22F9NO4S/c30-20-5-7-21(8-6-20)44(42,43)26-11-12-39(15-18-2-1-17(25(40)41)14-23(18)31)24(26)10-3-16-13-19(4-9-22(16)26)27(32,28(33,34)35)29(36,37)38/h1-2,4-9,13-14,24H,3,10-12,15H2,(H,40,41)/t24-,26-/m1/s1 PYCRWQVFXKWUCY-AOYPEHQESA-N 383044 US10273259, Example 755::US10711020, Example 755 Nuclear receptor ROR-gamma [262-507] 170 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383044 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383044&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679106 404852348 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931666 OC(=O)c1ccc(CN2CC[C@@]3([C@H]2CCc2cc(ccc32)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c2ccc(F)cc2)c(Cl)c1 InChI=1S/C29H22ClF8NO4S/c30-23-14-17(25(40)41)1-2-18(23)15-39-12-11-26(44(42,43)21-7-5-20(31)6-8-21)22-9-4-19(13-16(22)3-10-24(26)39)27(32,28(33,34)35)29(36,37)38/h1-2,4-9,13-14,24H,3,10-12,15H2,(H,40,41)/t24-,26-/m1/s1 PXASGAYFBLUWFN-AOYPEHQESA-N 383045 US10273259, Example 756::US10711020, Example 756 Nuclear receptor ROR-gamma [262-507] 54.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383045 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383045&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679109 404852349 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931667 OC(=O)c1cccc(CN2CC[C@@]3([C@H]2CCc2cc(ccc32)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c2ccc(F)cc2)c1 InChI=1S/C29H23F8NO4S/c30-21-6-8-22(9-7-21)43(41,42)26-12-13-38(16-17-2-1-3-19(14-17)25(39)40)24(26)11-4-18-15-20(5-10-23(18)26)27(31,28(32,33)34)29(35,36)37/h1-3,5-10,14-15,24H,4,11-13,16H2,(H,39,40)/t24-,26-/m1/s1 MZALTRIKZNXMQP-AOYPEHQESA-N 383046 US10273259, Example 757::US10711020, Example 757 Nuclear receptor ROR-gamma [262-507] 48.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383046 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383046&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679260 404852350 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931668 COc1cc(ccc1CN1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1)C(O)=O InChI=1S/C30H25F8NO5S/c1-44-24-15-18(26(40)41)2-3-19(24)16-39-13-12-27(45(42,43)22-8-6-21(31)7-9-22)23-10-5-20(14-17(23)4-11-25(27)39)28(32,29(33,34)35)30(36,37)38/h2-3,5-10,14-15,25H,4,11-13,16H2,1H3,(H,40,41)/t25-,27-/m1/s1 IMCOLAVLXWJYDN-XNMGPUDCSA-N 383047 US10273259, Example 758::US10711020, Example 758 Nuclear receptor ROR-gamma [262-507] 87.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383047 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383047&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678731 404852351 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931669 OC(=O)c1ccc(CN2CC[C@@]3([C@H]2CCc2cc(ccc32)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c2ccc(F)cc2)c(c1)C(O)=O InChI=1S/C30H23F8NO6S/c31-20-5-7-21(8-6-20)46(44,45)27-11-12-39(15-18-2-1-17(25(40)41)14-22(18)26(42)43)24(27)10-3-16-13-19(4-9-23(16)27)28(32,29(33,34)35)30(36,37)38/h1-2,4-9,13-14,24H,3,10-12,15H2,(H,40,41)(H,42,43)/t24-,27-/m1/s1 FNBSWLNILHSTGZ-SHQCIBLASA-N 383048 US10273259, Example 759::US10711020, Example 759 Nuclear receptor ROR-gamma [262-507] 107 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383048 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383048&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678772 404852352 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931670 CC(=O)N1CCC(CN2CC[C@@]3([C@H]2CCc2cc(ccc32)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c2ccc(F)cc2)CC1 InChI=1S/C29H30F8N2O3S/c1-18(40)38-13-10-19(11-14-38)17-39-15-12-26(43(41,42)23-6-4-22(30)5-7-23)24-8-3-21(16-20(24)2-9-25(26)39)27(31,28(32,33)34)29(35,36)37/h3-8,16,19,25H,2,9-15,17H2,1H3/t25-,26-/m1/s1 QVUOIGWWVITMCJ-CLJLJLNGSA-N 383049 1-(4-(((3aR,9bR)-9b-((4-fluorophenyl)sulfonyl)-7-(perfluoropropan-2-yl)-1,2,3a,4,5,9b-hexahydro-3H-benzo[e]indol-3-yl)methyl)piperidin-1-yl)ethan-1-one::US10273259, Example 760::US10711020, Example 760 Nuclear receptor ROR-gamma [262-507] 119 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383049 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383049&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122669220 404852353 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931671 Cn1ncnc1CN1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C25H22F8N4O2S/c1-36-21(34-14-35-36)13-37-11-10-22(40(38,39)18-6-4-17(26)5-7-18)19-8-3-16(12-15(19)2-9-20(22)37)23(27,24(28,29)30)25(31,32)33/h3-8,12,14,20H,2,9-11,13H2,1H3/t20-,22-/m1/s1 IBODDIAQDDHORD-IFMALSPDSA-N 383050 (3aR,9bR)-9b-((4-fluorophenyl)sulfonyl)-3-((1-methyl-1H-1,2,4-triazol-5-yl)methyl)-7-(perfluoropropan-2-yl)-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]indole::US10273259, Example 761::US10711020, Example 761 Nuclear receptor ROR-gamma [262-507] 112 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383050 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383050&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122669195 404852354 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931672 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN(Cc3ncc[nH]3)[C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F 383051 US10273259, Example 762::US10711020, Example 762 Nuclear receptor ROR-gamma [262-507] 309 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383051 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383051&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679158 404852355 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931673 Cn1ccnc1CN1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C26H23F8N3O2S/c1-36-13-11-35-22(36)15-37-12-10-23(40(38,39)19-6-4-18(27)5-7-19)20-8-3-17(14-16(20)2-9-21(23)37)24(28,25(29,30)31)26(32,33)34/h3-8,11,13-14,21H,2,9-10,12,15H2,1H3/t21-,23-/m1/s1 VKWYORZIUYAHCX-FYYLOGMGSA-N 383052 US10273259, Example 763::US10711020, Example 763 Nuclear receptor ROR-gamma [262-507] 109 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383052 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383052&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679281 404852356 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931674 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN(Cc3nnn[nH]3)[C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F 383053 US10273259, Example 764::US10711020, Example 764 Nuclear receptor ROR-gamma [262-507] 687 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383053 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383053&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 145995615 404852357 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931675 OC(=O)c1ccc(CN2CC[C@@]3([C@H]2CCc2cc(ccc32)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c2ccc(F)cc2)cc1 InChI=1S/C29H23F8NO4S/c30-21-7-9-22(10-8-21)43(41,42)26-13-14-38(16-17-1-3-18(4-2-17)25(39)40)24(26)12-5-19-15-20(6-11-23(19)26)27(31,28(32,33)34)29(35,36)37/h1-4,6-11,15,24H,5,12-14,16H2,(H,39,40)/t24-,26-/m1/s1 XAEAXIOTEFFAIN-AOYPEHQESA-N 383054 US10273259, Example 765::US10711020, Example 765 Nuclear receptor ROR-gamma [262-507] 208 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383054 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383054&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679267 404852358 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931676 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN(Cc3ccc(C#N)c(F)c3)[C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F InChI=1S/C29H21F9N2O2S/c30-21-5-7-22(8-6-21)43(41,42)26-11-12-40(16-17-1-2-19(15-39)24(31)13-17)25(26)10-3-18-14-20(4-9-23(18)26)27(32,28(33,34)35)29(36,37)38/h1-2,4-9,13-14,25H,3,10-12,16H2/t25-,26-/m1/s1 QWGXMGGFEJKXGH-CLJLJLNGSA-N 383055 US10273259, Example 766::US10711020, Example 766 Nuclear receptor ROR-gamma [262-507] 1348 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383055 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383055&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678921 404852359 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931677 OC(=O)c1ccccc1CN1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C29H23F8NO4S/c30-20-7-9-21(10-8-20)43(41,42)26-13-14-38(16-18-3-1-2-4-22(18)25(39)40)24(26)12-5-17-15-19(6-11-23(17)26)27(31,28(32,33)34)29(35,36)37/h1-4,6-11,15,24H,5,12-14,16H2,(H,39,40)/t24-,26-/m1/s1 ODQKPIKTNBRZHQ-AOYPEHQESA-N 383056 US10273259, Example 767::US10711020, Example 767 Nuclear receptor ROR-gamma [262-507] 91.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383056 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383056&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678766 404852360 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931678 OC(=O)c1ccc(CN2CC[C@@]3([C@H]2CCc2cc(ccc32)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c2ccc(F)cc2)cc1F InChI=1S/C29H22F9NO4S/c30-19-4-6-20(7-5-19)44(42,43)26-11-12-39(15-16-1-8-21(25(40)41)23(31)13-16)24(26)10-2-17-14-18(3-9-22(17)26)27(32,28(33,34)35)29(36,37)38/h1,3-9,13-14,24H,2,10-12,15H2,(H,40,41)/t24-,26-/m1/s1 VJGMLZZPOBQQHX-AOYPEHQESA-N 383057 US10273259, Example 768::US10711020, Example 768 Nuclear receptor ROR-gamma [262-507] 291 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383057 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383057&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678789 404852361 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931679 OC(=O)c1ccc(CN2CC[C@@]3([C@H]2CCc2cc(ccc32)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c2ccc(F)cc2)cc1Cl InChI=1S/C29H22ClF8NO4S/c30-23-13-16(1-8-21(23)25(40)41)15-39-12-11-26(44(42,43)20-6-4-19(31)5-7-20)22-9-3-18(14-17(22)2-10-24(26)39)27(32,28(33,34)35)29(36,37)38/h1,3-9,13-14,24H,2,10-12,15H2,(H,40,41)/t24-,26-/m1/s1 FJYXVQNSINUYKK-AOYPEHQESA-N 383058 US10273259, Example 769::US10711020, Example 769 Nuclear receptor ROR-gamma [262-507] 117 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383058 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383058&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678758 404852362 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931680 OC(=O)CN1C2CCc3cc(I)ccc3C2(CC1=O)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C20H17FINO5S/c21-13-2-5-15(6-3-13)29(27,28)20-10-18(24)23(11-19(25)26)17(20)8-1-12-9-14(22)4-7-16(12)20/h2-7,9,17H,1,8,10-11H2,(H,25,26) WDXLKIBSCQMVPW-UHFFFAOYSA-N 383059 9b-((4-fluorophenyl)sulfonyl)-7-iodo-2-oxo-1,2,3a,4,5,9b-hexahydro-3H-benzo[e]indol-3-yl)acetic acid::US10273259, Example 770::US10711020, Example 770 Nuclear receptor ROR-gamma [262-507] 9197 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383059 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383059&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122669257 404852363 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931681 CN1CCC2(C1CN(C)c1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C22H20F8N2O2S/c1-31-10-9-19(35(33,34)15-6-4-14(23)5-7-15)16-8-3-13(11-17(16)32(2)12-18(19)31)20(24,21(25,26)27)22(28,29)30/h3-8,11,18H,9-10,12H2,1-2H3 LAYZEJQWHLQYCR-UHFFFAOYSA-N 383060 9b-((4-fluorophenyl)sulfonyl)-35-dimethyl-7-(perfluoropropan-2-yl)-2,3,3a,4,5,9b-hexahydro-1H-pyrrolo[2,3-c]quinolone::US10273259, Example 771::US10711020, Example 771 Nuclear receptor ROR-gamma [262-507] 157 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383060 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383060&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122669044 404852364 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931682 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)c1ccccc1 InChI=1S/C27H21F8NO2S/c28-19-8-10-21(11-9-19)39(37,38)24-14-15-36(20-4-2-1-3-5-20)23(24)13-6-17-16-18(7-12-22(17)24)25(29,26(30,31)32)27(33,34)35/h1-5,7-12,16,23H,6,13-15H2/t23-,24-/m1/s1 VLTICJRVEWWLEX-DNQXCXABSA-N 383061 (3aR,9bR)-9b-((4-fluorophenyl)sulfonyl)-7-(perfluoropropan-2-yl)-3-phenyl-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]indole::US10273259, Example 772::US10711020, Example 772 Nuclear receptor ROR-gamma [262-507] 609 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383061 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383061&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122669249 404852365 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931683 OC(=O)c1ccc(cc1)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H21F8NO4S/c29-19-5-9-21(10-6-19)42(40,41)25-13-14-37(20-7-1-16(2-8-20)24(38)39)23(25)12-3-17-15-18(4-11-22(17)25)26(30,27(31,32)33)28(34,35)36/h1-2,4-11,15,23H,3,12-14H2,(H,38,39)/t23-,25-/m1/s1 CFYBAAUCYHKAOS-ILBGXUMGSA-N 383062 4-((3aR,9bR)-9b-((4-fluorophenyl)sulfonyl)-7-(perfluoropropan-2-yl)-1,2,3a,4,5,9b-hexahydro-3H-benzo[e]indol-3-yl)benzoic acid::US10273259, Example 773::US10711020, Example 773 Nuclear receptor ROR-gamma [262-507] 1801 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383062 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383062&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122669122 404852366 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931684 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)c1ccccn1 InChI=1S/C26H20F8N2O2S/c27-18-6-8-19(9-7-18)39(37,38)23-12-14-36(22-3-1-2-13-35-22)21(23)11-4-16-15-17(5-10-20(16)23)24(28,25(29,30)31)26(32,33)34/h1-3,5-10,13,15,21H,4,11-12,14H2/t21-,23-/m1/s1 ZEAXVASESOSYJP-FYYLOGMGSA-N 383063 (3aR,9bR)-9b-((4-fluorophenyl)sulfonyl)-7-(perfluoropropan-2-yl)-3-(pyridin-2-yl)-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]indole::US10273259, Example 774::US10711020, Example 774 Nuclear receptor ROR-gamma [262-507] 679 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383063 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383063&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122669140 404852367 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931685 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)c1ccccc1F InChI=1S/C27H20F9NO2S/c28-18-7-9-19(10-8-18)40(38,39)24-13-14-37(22-4-2-1-3-21(22)29)23(24)12-5-16-15-17(6-11-20(16)24)25(30,26(31,32)33)27(34,35)36/h1-4,6-11,15,23H,5,12-14H2/t23-,24-/m1/s1 UVFZYKMNWWAUHO-DNQXCXABSA-N 383064 US10273259, Example 775::US10711020, Example 775 Nuclear receptor ROR-gamma [262-507] 534 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383064 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383064&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679174 404852368 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931686 OC(=O)c1cccc(c1)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H21F8NO4S/c29-19-6-8-21(9-7-19)42(40,41)25-12-13-37(20-3-1-2-17(15-20)24(38)39)23(25)11-4-16-14-18(5-10-22(16)25)26(30,27(31,32)33)28(34,35)36/h1-3,5-10,14-15,23H,4,11-13H2,(H,38,39)/t23-,25-/m1/s1 LHVUXKYHVZPDMP-ILBGXUMGSA-N 383065 US10273259, Example 776::US10711020, Example 776 Nuclear receptor ROR-gamma [262-507] 1490 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383065 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383065&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678915 404852369 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931687 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)c1cccnc1 InChI=1S/C26H20F8N2O2S/c27-18-5-7-20(8-6-18)39(37,38)23-11-13-36(19-2-1-12-35-15-19)22(23)10-3-16-14-17(4-9-21(16)23)24(28,25(29,30)31)26(32,33)34/h1-2,4-9,12,14-15,22H,3,10-11,13H2/t22-,23-/m1/s1 CLHCWIIGEYZMFU-DHIUTWEWSA-N 383066 US10273259, Example 777::US10711020, Example 777 Nuclear receptor ROR-gamma [262-507] 493 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383066 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383066&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679164 404852370 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931688 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)c1ccnnc1 InChI=1S/C25H19F8N3O2S/c26-17-3-5-19(6-4-17)39(37,38)22-10-12-36(18-9-11-34-35-14-18)21(22)8-1-15-13-16(2-7-20(15)22)23(27,24(28,29)30)25(31,32)33/h2-7,9,11,13-14,21H,1,8,10,12H2/t21-,22-/m1/s1 RIYFFVQPAHUUTF-FGZHOGPDSA-N 383067 US10273259, Example 778::US10711020, Example 778 Nuclear receptor ROR-gamma [262-507] 171 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383067 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383067&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679277 404852371 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931689 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)c1cccnn1 InChI=1S/C25H19F8N3O2S/c26-17-5-7-18(8-6-17)39(37,38)22-11-13-36(21-2-1-12-34-35-21)20(22)10-3-15-14-16(4-9-19(15)22)23(27,24(28,29)30)25(31,32)33/h1-2,4-9,12,14,20H,3,10-11,13H2/t20-,22-/m1/s1 FLRNTNCTFKBARE-IFMALSPDSA-N 383068 US10273259, Example 779::US10711020, Example 779 Nuclear receptor ROR-gamma [262-507] 283 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383068 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383068&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678795 404852372 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931690 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)c1cncnc1 InChI=1S/C25H19F8N3O2S/c26-17-3-5-19(6-4-17)39(37,38)22-9-10-36(18-12-34-14-35-13-18)21(22)8-1-15-11-16(2-7-20(15)22)23(27,24(28,29)30)25(31,32)33/h2-7,11-14,21H,1,8-10H2/t21-,22-/m1/s1 UVXMBBAZSDTQSU-FGZHOGPDSA-N 383069 US10273259, Example 780::US10711020, Example 780 Nuclear receptor ROR-gamma [262-507] 97.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383069 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383069&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679178 404852373 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931691 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)c1cnccn1 InChI=1S/C25H19F8N3O2S/c26-17-3-5-18(6-4-17)39(37,38)22-9-12-36(21-14-34-10-11-35-21)20(22)8-1-15-13-16(2-7-19(15)22)23(27,24(28,29)30)25(31,32)33/h2-7,10-11,13-14,20H,1,8-9,12H2/t20-,22-/m1/s1 JBISLVMOEUMVIA-IFMALSPDSA-N 383070 US10273259, Example 781::US10711020, Example 781 Nuclear receptor ROR-gamma [262-507] 913 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383070 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383070&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679163 404852374 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931692 CS(=O)(=O)c1ccc(cc1)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H23F8NO4S2/c1-42(38,39)21-10-6-20(7-11-21)37-15-14-25(43(40,41)22-8-4-19(29)5-9-22)23-12-3-18(16-17(23)2-13-24(25)37)26(30,27(31,32)33)28(34,35)36/h3-12,16,24H,2,13-15H2,1H3/t24-,25-/m1/s1 VWHOERRGZINANJ-JWQCQUIFSA-N 383071 US10273259, Example 782::US10711020, Example 782 Nuclear receptor ROR-gamma [262-507] 148 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383071 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383071&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679176 404852375 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931693 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)c1ncccn1 InChI=1S/C25H19F8N3O2S/c26-17-4-6-18(7-5-17)39(37,38)22-10-13-36(21-34-11-1-12-35-21)20(22)9-2-15-14-16(3-8-19(15)22)23(27,24(28,29)30)25(31,32)33/h1,3-8,11-12,14,20H,2,9-10,13H2/t20-,22-/m1/s1 IBWPTNJDHOEHGP-IFMALSPDSA-N 383072 US10273259, Example 783::US10711020, Example 783 Nuclear receptor ROR-gamma [262-507] 507 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383072 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383072&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679173 404852376 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931694 CS(=O)(=O)c1cccc(c1)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H23F8NO4S2/c1-42(38,39)22-4-2-3-20(16-22)37-14-13-25(43(40,41)21-9-7-19(29)8-10-21)23-11-6-18(15-17(23)5-12-24(25)37)26(30,27(31,32)33)28(34,35)36/h2-4,6-11,15-16,24H,5,12-14H2,1H3/t24-,25-/m1/s1 TWZOUPREUPGMLE-JWQCQUIFSA-N 383073 US10273259, Example 784::US10711020, Example 784 Nuclear receptor ROR-gamma [262-507] 154 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383073 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383073&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678904 404852377 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 930915 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C29H27F8NO5S/c30-20-7-9-21(10-8-20)44(42,43)26-13-14-38(24(39)16-1-3-17(4-2-16)25(40)41)23(26)12-5-18-15-19(6-11-22(18)26)27(31,28(32,33)34)29(35,36)37/h6-11,15-17,23H,1-5,12-14H2,(H,40,41)/t16-,17-,23-,26-/m1/s1 FEJZVGPREBSBIT-NIULTJEISA-N 382173 (1R,4r)-4-((3aR,9bR)-9b-((4-fluorophenyl)sulfonyl)-7-(perfluoropropan-2-yl)-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]indole-3-carbonyl)cyclohexane-1-carboxylic acid::US10273259, Example 1::US10711020, Example 1 Nuclear receptor ROR-gamma [262-507] 70.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382173 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382173&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search O5B 6U25 122669106 404851546 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 930916 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CCCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C30H29F8NO5S/c31-21-8-10-22(11-9-21)45(43,44)27-14-1-15-39(25(40)17-2-4-18(5-3-17)26(41)42)24(27)13-6-19-16-20(7-12-23(19)27)28(32,29(33,34)35)30(36,37)38/h7-12,16-18,24H,1-6,13-15H2,(H,41,42)/t17-,18-,24?,27? KRERFHRWSYRZOW-VRSFHCCXSA-N 382176 (1r,4r)-4-(10b-((4-fluorophenyl)sulfonyl)-8-(perfluoropropan-2-yl)-1,2,3,4,4a,5,6,10b-octahydrobenzo[f]quinoline-4-carbonyl)cyclohexane-1-carboxylic acid (Homochiral)::US10273259, Example 2::US10711020, Example 2 Nuclear receptor ROR-gamma [262-507] 89.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382176 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382176&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122669184 404851549 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 930917 OC(=O)[C@@]1(F)CC[C@@H](CC1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C29H26F9NO5S/c30-19-3-5-20(6-4-19)45(43,44)26-13-14-39(23(40)16-9-11-25(31,12-10-16)24(41)42)22(26)8-1-17-15-18(2-7-21(17)26)27(32,28(33,34)35)29(36,37)38/h2-7,15-16,22H,1,8-14H2,(H,41,42)/t16-,22-,25+,26-/m1/s1 SDFPTMOGHKGDAX-PNOGGZOTSA-N 453042 (1S,4s)-4-fluoro-4-((3aR,9bR)-9b-((4-fluorophenyl)sulfonyl)-7-(perfluoropropan-2-yl)-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]indole-3-carbonyl)cyclohexane-1-carboxylic Acid and (1S,4s)-1-fluoro-4-((3aR,9bR)-9b-((4-fluorophenyl)sulfonyl)-7-(perfluoropropan-2-yl)-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]indole-3-carbonyl)cyclohexane-1-carboxylic Acid::US10711020, Example 3::US10711020, Example 4 Nuclear receptor ROR-gamma [262-507] 65.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=453042 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=453042&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122669256 440969010 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 930918 OC(=O)[C@@]1(F)CC[C@@H](CC1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C29H26F9NO5S/c30-19-3-5-20(6-4-19)45(43,44)26-13-14-39(23(40)16-9-11-25(31,12-10-16)24(41)42)22(26)8-1-17-15-18(2-7-21(17)26)27(32,28(33,34)35)29(36,37)38/h2-7,15-16,22H,1,8-14H2,(H,41,42)/t16-,22-,25+,26-/m1/s1 SDFPTMOGHKGDAX-PNOGGZOTSA-N 453042 (1S,4s)-4-fluoro-4-((3aR,9bR)-9b-((4-fluorophenyl)sulfonyl)-7-(perfluoropropan-2-yl)-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]indole-3-carbonyl)cyclohexane-1-carboxylic Acid and (1S,4s)-1-fluoro-4-((3aR,9bR)-9b-((4-fluorophenyl)sulfonyl)-7-(perfluoropropan-2-yl)-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]indole-3-carbonyl)cyclohexane-1-carboxylic Acid::US10711020, Example 3::US10711020, Example 4 Nuclear receptor ROR-gamma [262-507] 107 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=453042 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=453042&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122669256 440969010 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 930919 CC[C@@]1(CC[C@@H](CC1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1)C(O)=O InChI=1S/C31H31F8NO5S/c1-2-27(26(42)43)13-11-18(12-14-27)25(41)40-16-15-28(46(44,45)22-7-5-21(32)6-8-22)23-9-4-20(17-19(23)3-10-24(28)40)29(33,30(34,35)36)31(37,38)39/h4-9,17-18,24H,2-3,10-16H2,1H3,(H,42,43)/t18-,24-,27-,28-/m1/s1 YUIPIAPKYWCRFZ-IOPUSJGHSA-N 382187 (1R,4r)-1-ethyl-4-((3aR,9bR)-9b-((4-fluorophenyl)sulfonyl)-7-(perfluoropropan-2-yl)-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]indole-3-carbonyl)cyclohexane-1-carboxylic acid::US10273259, Example 5::US10711020, Example 5 Nuclear receptor ROR-gamma [262-507] 240 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382187 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382187&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122669274 404851560 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 930920 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1CCNCC1 InChI=1S/C27H26F8N2O3S/c28-19-3-5-20(6-4-19)41(39,40)24-11-14-37(23(38)16-9-12-36-13-10-16)22(24)8-1-17-15-18(2-7-21(17)24)25(29,26(30,31)32)27(33,34)35/h2-7,15-16,22,36H,1,8-14H2/t22-,24-/m1/s1 VPZRGOPJQVWEFS-ISKFKSNPSA-N 382190 ((3aR,9bR)-9b-((4-fluorophenyl)sulfonyl)-7-(perfluoropropan-2-yl)-1,2,3a,4,5,9b-hexahydro-3H-benzo[e]indol-3-yl)(piperidin-4-yl)methanone::US10273259, Example 6::US10711020, Example 6 Nuclear receptor ROR-gamma [262-507] 257 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382190 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382190&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122669042 404851563 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 930921 OC(=O)c1ccc(cc1)S(=O)(=O)C1CCC2(C1Cc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H20F8O6S2/c29-18-4-8-20(9-5-18)44(41,42)25-12-11-23(43(39,40)19-6-1-15(2-7-19)24(37)38)22(25)14-16-13-17(3-10-21(16)25)26(30,27(31,32)33)28(34,35)36/h1-10,13,22-23H,11-12,14H2,(H,37,38) RCTNJCNTSQPPTJ-UHFFFAOYSA-N 453046 4-((3a-((4-fluorophenyl)sulfonyl)-6-(perfluoropropan-2-yl)-3,3a,8,8a-tetrahydroindeno[2,1-b]pyrrol-1 (2H)-yl)sulfonyl)benzoic Acid::US10711020, Example 7 Nuclear receptor ROR-gamma [262-507] 1033 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=453046 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=453046&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 139386967 440969013 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 930922 OC(=O)C12CCC(CC1)(CC2)C(=O)N1CC[C@]2([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C31H29F8NO5S/c32-20-3-5-21(6-4-20)46(44,45)28-15-16-40(24(41)26-9-12-27(13-10-26,14-11-26)25(42)43)23(28)8-1-18-17-19(2-7-22(18)28)29(33,30(34,35)36)31(37,38)39/h2-7,17,23H,1,8-16H2,(H,42,43)/t23-,26?,27?,28-/m0/s1 FLJYXIWKPNZXTJ-LWGYBYOHSA-N 382192 US10273259, Example 8::US10711020, Example 8 Nuclear receptor ROR-gamma [262-507] 4277 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382192 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382192&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678634 404851565 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 930923 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CC[C@]2([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C29H27F8NO5S/c30-20-7-9-21(10-8-20)44(42,43)26-13-14-38(24(39)16-1-3-17(4-2-16)25(40)41)23(26)12-5-18-15-19(6-11-22(18)26)27(31,28(32,33)34)29(35,36)37/h6-11,15-17,23H,1-5,12-14H2,(H,40,41)/t16-,17-,23-,26-/m0/s1 FEJZVGPREBSBIT-NOTBVDQOSA-N 382193 US10273259, Example 9::US10711020, Example 9 Nuclear receptor ROR-gamma [262-507] 5354 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382193 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382193&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678940 404851566 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 930924 Fc1ccc(cc1)S(=O)(=O)[C@]12CCN([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1CCS(=O)(=O)CC1 InChI=1S/C27H25F8NO5S2/c28-19-3-5-20(6-4-19)43(40,41)24-11-12-36(23(37)16-9-13-42(38,39)14-10-16)22(24)8-1-17-15-18(2-7-21(17)24)25(29,26(30,31)32)27(33,34)35/h2-7,15-16,22H,1,8-14H2/t22-,24-/m0/s1 KJYXXEYJECOAQK-UPVQGACJSA-N 382194 US10273259, Example 10::US10711020, Example 10 Nuclear receptor ROR-gamma [262-507] 8688 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382194 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382194&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678826 404851567 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 930925 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1CCS(=O)(=O)CC1 InChI=1S/C27H25F8NO5S2/c28-19-3-5-20(6-4-19)43(40,41)24-11-12-36(23(37)16-9-13-42(38,39)14-10-16)22(24)8-1-17-15-18(2-7-21(17)24)25(29,26(30,31)32)27(33,34)35/h2-7,15-16,22H,1,8-14H2/t22-,24-/m1/s1 KJYXXEYJECOAQK-ISKFKSNPSA-N 382195 US10273259, Example 11::US10711020, Example 11 Nuclear receptor ROR-gamma [262-507] 107 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382195 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382195&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678562 404851568 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 930926 OC(=O)C12CCC(CC1)(CC2)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C31H29F8NO5S/c32-20-3-5-21(6-4-20)46(44,45)28-15-16-40(24(41)26-9-12-27(13-10-26,14-11-26)25(42)43)23(28)8-1-18-17-19(2-7-22(18)28)29(33,30(34,35)36)31(37,38)39/h2-7,17,23H,1,8-16H2,(H,42,43)/t23-,26?,27?,28-/m1/s1 FLJYXIWKPNZXTJ-LJJHVHFXSA-N 382198 US10273259, Example 12::US10711020, Example 12 Nuclear receptor ROR-gamma [262-507] 118 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382198 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382198&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678563 404851571 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 930927 CC(=O)N1CCC(CC1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C29H28F8N2O4S/c1-17(40)38-13-10-18(11-14-38)25(41)39-15-12-26(44(42,43)22-6-4-21(30)5-7-22)23-8-3-20(16-19(23)2-9-24(26)39)27(31,28(32,33)34)29(35,36)37/h3-8,16,18,24H,2,9-15H2,1H3/t24-,26-/m1/s1 KRFUPWONDXEJMB-AOYPEHQESA-N 382201 US10273259, Example 13::US10711020, Example 13 Nuclear receptor ROR-gamma [262-507] 144 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382201 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382201&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678748 404851574 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 930928 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(Cl)cc1 InChI=1S/C29H27ClF7NO5S/c30-20-7-9-21(10-8-20)44(42,43)26-13-14-38(24(39)16-1-3-17(4-2-16)25(40)41)23(26)12-5-18-15-19(6-11-22(18)26)27(31,28(32,33)34)29(35,36)37/h6-11,15-17,23H,1-5,12-14H2,(H,40,41)/t16-,17-,23?,26? ASSZTGFDWPKORU-LRVXPCDCSA-N 382210 US10273259, Example 14::US10711020, Example 14 Nuclear receptor ROR-gamma [262-507] 62.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382210 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382210&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122669076 404851583 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 930929 OC(=O)C12CCC(CC1)(CC2)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(Cl)cc1 InChI=1S/C31H29ClF7NO5S/c32-20-3-5-21(6-4-20)46(44,45)28-15-16-40(24(41)26-9-12-27(13-10-26,14-11-26)25(42)43)23(28)8-1-18-17-19(2-7-22(18)28)29(33,30(34,35)36)31(37,38)39/h2-7,17,23H,1,8-16H2,(H,42,43) MXCMTPXIOAQXRW-UHFFFAOYSA-N 382213 US10273259, Example 15::US10711020, Example 15 Nuclear receptor ROR-gamma [262-507] 185 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382213 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382213&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678636 404851586 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 930930 FC(F)(F)C(F)(c1ccc2c(CCC3N(CCC23S(=O)(=O)c2ccc(Cl)cc2)C(=O)C2CCS(=O)(=O)CC2)c1)C(F)(F)F InChI=1S/C27H25ClF7NO5S2/c28-19-3-5-20(6-4-19)43(40,41)24-11-12-36(23(37)16-9-13-42(38,39)14-10-16)22(24)8-1-17-15-18(2-7-21(17)24)25(29,26(30,31)32)27(33,34)35/h2-7,15-16,22H,1,8-14H2 NLPUXOGOYTUJOR-UHFFFAOYSA-N 382216 US10273259, Example 16::US10711020, Example 16 Nuclear receptor ROR-gamma [262-507] 142 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382216 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382216&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678949 404851589 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 930931 CC(=O)N1CCC(CC1)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(Cl)cc1 InChI=1S/C29H28ClF7N2O4S/c1-17(40)38-13-10-18(11-14-38)25(41)39-15-12-26(44(42,43)22-6-4-21(30)5-7-22)23-8-3-20(16-19(23)2-9-24(26)39)27(31,28(32,33)34)29(35,36)37/h3-8,16,18,24H,2,9-15H2,1H3 YDMFQZHRZPJOTG-UHFFFAOYSA-N 382228 US10273259, Example 17::US10711020, Example 17 Nuclear receptor ROR-gamma [262-507] 184 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382228 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382228&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678646 404851601 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 930932 CC[C@@]1(CC[C@@H](CC1)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(Cl)cc1)C(O)=O InChI=1S/C31H31ClF7NO5S/c1-2-27(26(42)43)13-11-18(12-14-27)25(41)40-16-15-28(46(44,45)22-7-5-21(32)6-8-22)23-9-4-20(17-19(23)3-10-24(28)40)29(33,30(34,35)36)31(37,38)39/h4-9,17-18,24H,2-3,10-16H2,1H3,(H,42,43)/t18-,24?,27-,28? NFBHREOTIAWPGV-GLMFJJLTSA-N 382231 US10273259, Example 18::US10711020, Example 18 Nuclear receptor ROR-gamma [262-507] 189 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382231 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382231&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678637 404851604 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 930933 Cc1ccc(cc1)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)[C@H]1CC[C@@H](CC1)C(O)=O InChI=1S/C30H30F7NO5S/c1-17-2-10-22(11-3-17)44(42,43)27-14-15-38(25(39)18-4-6-19(7-5-18)26(40)41)24(27)13-8-20-16-21(9-12-23(20)27)28(31,29(32,33)34)30(35,36)37/h2-3,9-12,16,18-19,24H,4-8,13-15H2,1H3,(H,40,41)/t18-,19-,24?,27? JDFDTUYICUVLET-QXIWJBPRSA-N 382232 US10273259, Example 19::US10711020, Example 144 Nuclear receptor ROR-gamma [262-507] 95.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382232 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382232&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678564 404851605 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 930934 Cc1ccc(cc1)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C12CCC(CC1)(CC2)C(O)=O InChI=1S/C32H32F7NO5S/c1-19-2-6-22(7-3-19)46(44,45)29-16-17-40(25(41)27-10-13-28(14-11-27,15-12-27)26(42)43)24(29)9-4-20-18-21(5-8-23(20)29)30(33,31(34,35)36)32(37,38)39/h2-3,5-8,18,24H,4,9-17H2,1H3,(H,42,43) SNKGBBUIANWTAE-UHFFFAOYSA-N 382233 US10273259, Example 141::US10273259, Example 20::US10711020, Example 141 Nuclear receptor ROR-gamma [262-507] 173 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382233 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382233&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678830 404851606 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 930935 Cc1ccc(cc1)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1CCS(=O)(=O)CC1 InChI=1S/C28H28F7NO5S2/c1-17-2-6-21(7-3-17)43(40,41)25-12-13-36(24(37)18-10-14-42(38,39)15-11-18)23(25)9-4-19-16-20(5-8-22(19)25)26(29,27(30,31)32)28(33,34)35/h2-3,5-8,16,18,23H,4,9-15H2,1H3 HUUCAOJGFRCTLB-UHFFFAOYSA-N 382234 US10273259, Example 21::US10711020, Example 21 Nuclear receptor ROR-gamma [262-507] 244 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382234 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382234&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678565 404851607 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 930936 CC(=O)N1CCC(CC1)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(C)cc1 InChI=1S/C30H31F7N2O4S/c1-18-3-7-23(8-4-18)44(42,43)27-13-16-39(26(41)20-11-14-38(15-12-20)19(2)40)25(27)10-5-21-17-22(6-9-24(21)27)28(31,29(32,33)34)30(35,36)37/h3-4,6-9,17,20,25H,5,10-16H2,1-2H3 JCYFRJDYEMDURJ-UHFFFAOYSA-N 382237 US10273259, Example 22::US10711020, Example 22 Nuclear receptor ROR-gamma [262-507] 137 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382237 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382237&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678751 404851610 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 930937 OC(=O)C12CCC(CC1)(CC2)C(=O)N1CCC2(C1COc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C30H27F8NO6S/c31-18-2-4-19(5-3-18)46(43,44)27-13-14-39(23(40)25-7-10-26(11-8-25,12-9-25)24(41)42)22(27)16-45-21-15-17(1-6-20(21)27)28(32,29(33,34)35)30(36,37)38/h1-6,15,22H,7-14,16H2,(H,41,42) BZZRJNNQLSEHON-UHFFFAOYSA-N 382238 US10273259, Example 23::US10711020, Example 23 Nuclear receptor ROR-gamma [262-507] 88.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382238 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382238&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678846 404851611 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 930938 CC(=O)N1CCC(CC1)C(=O)N1CCC2(C1COc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H26F8N2O5S/c1-16(39)37-11-8-17(9-12-37)24(40)38-13-10-25(44(41,42)20-5-3-19(29)4-6-20)21-7-2-18(14-22(21)43-15-23(25)38)26(30,27(31,32)33)28(34,35)36/h2-7,14,17,23H,8-13,15H2,1H3 IOJQPUUQUCLAAF-UHFFFAOYSA-N 382239 US10273259, Example 24::US10711020, Example 24 Nuclear receptor ROR-gamma [262-507] 132 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382239 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382239&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678647 404851612 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 930939 Fc1ccc(cc1)S(=O)(=O)C12CCN(C1COc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1CCS(=O)(=O)CC1 InChI=1S/C26H23F8NO6S2/c27-17-2-4-18(5-3-17)43(39,40)23-9-10-35(22(36)15-7-11-42(37,38)12-8-15)21(23)14-41-20-13-16(1-6-19(20)23)24(28,25(29,30)31)26(32,33)34/h1-6,13,15,21H,7-12,14H2 ZPONGLWUJBFKPH-UHFFFAOYSA-N 382240 US10273259, Example 25::US10711020, Example 33 Nuclear receptor ROR-gamma [262-507] 152 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382240 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382240&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678847 404851613 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 930940 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CCC2(C1COc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H25F8NO6S/c29-18-6-8-19(9-7-18)44(41,42)25-11-12-37(23(38)15-1-3-16(4-2-15)24(39)40)22(25)14-43-21-13-17(5-10-20(21)25)26(30,27(31,32)33)28(34,35)36/h5-10,13,15-16,22H,1-4,11-12,14H2,(H,39,40)/t15-,16-,22?,25? USEIONJENDBBQE-QAXNPQHNSA-N 382241 US10273259, Example 26::US10711020, Example 26 Nuclear receptor ROR-gamma [262-507] 100.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382241 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382241&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678639 404851614 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 930941 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CCC2(C1CCc1cc(I)ccc21)S(=O)(=O)c1ccc(Cl)cc1 InChI=1S/C26H27ClINO5S/c27-19-6-9-21(10-7-19)35(33,34)26-13-14-29(24(30)16-1-3-17(4-2-16)25(31)32)23(26)12-5-18-15-20(28)8-11-22(18)26/h6-11,15-17,23H,1-5,12-14H2,(H,31,32)/t16-,17-,23?,26? HCRPMCCZKBAYDI-LRVXPCDCSA-N 382242 US10273259, Example 27::US10711020, Example 27 Nuclear receptor ROR-gamma [262-507] 78.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382242 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382242&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122669196 404851615 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 930942 CC(=O)N1CCC(CC1)C(=O)N1CCC2(C1CCc1cc(I)ccc21)S(=O)(=O)c1ccc(Cl)cc1 InChI=1S/C26H28ClIN2O4S/c1-17(31)29-13-10-18(11-14-29)25(32)30-15-12-26(35(33,34)22-6-3-20(27)4-7-22)23-8-5-21(28)16-19(23)2-9-24(26)30/h3-8,16,18,24H,2,9-15H2,1H3 FTNZAMXFFGTXMQ-UHFFFAOYSA-N 382243 US10273259, Example 28::US10711020, Example 28 Nuclear receptor ROR-gamma [262-507] 155 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382243 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382243&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678763 404851616 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 930943 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CCC2(C1CCc1cc(ccc21)C(O)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(Cl)cc1 InChI=1S/C29H28ClF6NO6S/c30-20-7-9-21(10-8-20)44(42,43)26-13-14-37(24(38)16-1-3-17(4-2-16)25(39)40)23(26)12-5-18-15-19(6-11-22(18)26)27(41,28(31,32)33)29(34,35)36/h6-11,15-17,23,41H,1-5,12-14H2,(H,39,40)/t16-,17-,23?,26? LRBGRUQIKSHSNG-LRVXPCDCSA-N 382244 US10273259, Example 29::US10711020, Example 29 Nuclear receptor ROR-gamma [262-507] 330 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382244 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382244&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678760 404851617 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 930944 Cc1ccc(cc1)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)[C@H]1CC[C@@](F)(CC1)C(O)=O InChI=1S/C30H29F8NO5S/c1-17-2-6-21(7-3-17)45(43,44)27-14-15-39(24(40)18-10-12-26(31,13-11-18)25(41)42)23(27)9-4-19-16-20(5-8-22(19)27)28(32,29(33,34)35)30(36,37)38/h2-3,5-8,16,18,23H,4,9-15H2,1H3,(H,41,42)/t18-,23?,26+,27? WPGVXUGXFMJDHZ-MJALUPOVSA-N 382247 US10273259, Example 31::US10711020, Example 31 Nuclear receptor ROR-gamma [262-507] 81.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382247 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382247&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678955 404851620 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 930945 Cc1ccc(cc1)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)[C@@]1(F)CC[C@@H](CC1)C(O)=O InChI=1S/C30H29F8NO5S/c1-17-2-6-21(7-3-17)45(43,44)27-14-15-39(25(42)26(31)12-10-18(11-13-26)24(40)41)23(27)9-4-19-16-20(5-8-22(19)27)28(32,29(33,34)35)30(36,37)38/h2-3,5-8,16,18,23H,4,9-15H2,1H3,(H,40,41)/t18-,23?,26+,27? RWJCYGUITJAVMC-MJALUPOVSA-N 382248 US10273259, Example 32::US10711020, Example 145 Nuclear receptor ROR-gamma [262-507] 199 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382248 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382248&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678757 404851621 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 930946 Fc1ccc(cc1)S(=O)(=O)C12CCN(C1COc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1CCS(=O)(=O)CC1 InChI=1S/C26H23F8NO6S2/c27-17-2-4-18(5-3-17)43(39,40)23-9-10-35(22(36)15-7-11-42(37,38)12-8-15)21(23)14-41-20-13-16(1-6-19(20)23)24(28,25(29,30)31)26(32,33)34/h1-6,13,15,21H,7-12,14H2 ZPONGLWUJBFKPH-UHFFFAOYSA-N 382240 US10273259, Example 25::US10711020, Example 33 Nuclear receptor ROR-gamma [262-507] 290 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382240 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382240&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678847 404851613 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 930947 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(I)ccc21)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C26H27FINO5S/c27-19-6-9-21(10-7-19)35(33,34)26-13-14-29(24(30)16-1-3-17(4-2-16)25(31)32)23(26)12-5-18-15-20(28)8-11-22(18)26/h6-11,15-17,23H,1-5,12-14H2,(H,31,32)/t16-,17-,23-,26-/m1/s1 LBVNOAQYAAENHP-NIULTJEISA-N 382250 US10273259, Example 34::US10711020, Example 34 Nuclear receptor ROR-gamma [262-507] 75.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382250 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382250&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678638 404851623 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 930948 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CCC2(C1CCc1ccccc21)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C26H28FNO5S/c27-20-10-12-21(13-11-20)34(32,33)26-15-16-28(23(26)14-9-17-3-1-2-4-22(17)26)24(29)18-5-7-19(8-6-18)25(30)31/h1-4,10-13,18-19,23H,5-9,14-16H2,(H,30,31)/t18-,19-,23?,26? DGTWLLIIGJFLFZ-XVFBROAMSA-N 382251 US10273259, Example 35::US10711020, Example 35 Nuclear receptor ROR-gamma [262-507] 549 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382251 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382251&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678641 404851624 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 930949 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CCC2(C1COc1cc(ccc21)C(O)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H26F7NO7S/c29-18-6-8-19(9-7-18)44(41,42)25-11-12-36(23(37)15-1-3-16(4-2-15)24(38)39)22(25)14-43-21-13-17(5-10-20(21)25)26(40,27(30,31)32)28(33,34)35/h5-10,13,15-16,22,40H,1-4,11-12,14H2,(H,38,39)/t15-,16-,22?,25? IGNYNNABJSQDLQ-QAXNPQHNSA-N 382252 US10273259, Example 36::US10711020, Example 36 Nuclear receptor ROR-gamma [262-507] 218 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382252 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382252&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678957 404851625 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 930950 OC(=O)C12CCC(CC1)(CC2)C(=O)N1CCC2(C1COc1cc(ccc21)C(O)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C30H28F7NO7S/c31-18-2-4-19(5-3-18)46(43,44)27-13-14-38(23(39)25-7-10-26(11-8-25,12-9-25)24(40)41)22(27)16-45-21-15-17(1-6-20(21)27)28(42,29(32,33)34)30(35,36)37/h1-6,15,22,42H,7-14,16H2,(H,40,41) TWKHJFBPVIAUHN-UHFFFAOYSA-N 382253 US10273259, Example 37::US10711020, Example 37 Nuclear receptor ROR-gamma [262-507] 2437 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382253 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382253&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678834 404851626 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 930951 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(O)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C29H28F7NO6S/c30-20-7-9-21(10-8-20)44(42,43)26-13-14-37(24(38)16-1-3-17(4-2-16)25(39)40)23(26)12-5-18-15-19(6-11-22(18)26)27(41,28(31,32)33)29(34,35)36/h6-11,15-17,23,41H,1-5,12-14H2,(H,39,40)/t16-,17-,23-,26-/m1/s1 QTZGEDRMPXBKMK-NIULTJEISA-N 382254 US10273259, Example 38::US10711020, Example 38 Nuclear receptor ROR-gamma [262-507] 5608 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382254 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382254&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678765 404851627 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 930952 FC(F)(F)c1ccc2c(CCC3N(CCC23S(=O)(=O)c2ccc(Cl)cc2)C(=O)C2CCS(=O)(=O)CC2)c1 InChI=1S/C25H25ClF3NO5S2/c26-19-3-5-20(6-4-19)37(34,35)24-11-12-30(23(31)16-9-13-36(32,33)14-10-16)22(24)8-1-17-15-18(25(27,28)29)2-7-21(17)24/h2-7,15-16,22H,1,8-14H2 GHBGUBPJQYJPKX-UHFFFAOYSA-N 453077 US10711020, Example 39 Nuclear receptor ROR-gamma [262-507] 24.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=453077 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=453077&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678961 440969044 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 930953 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(F)F)S(=O)(=O)c1ccc(Cl)cc1 InChI=1S/C27H27ClF3NO5S/c28-20-7-9-21(10-8-20)38(36,37)26-13-14-32(24(33)16-1-3-17(4-2-16)25(34)35)23(26)12-5-18-15-19(27(29,30)31)6-11-22(18)26/h6-11,15-17,23H,1-5,12-14H2,(H,34,35)/t16-,17-,23?,26? BCJWUAOZGZZKDJ-LRVXPCDCSA-N 382258 US10273259, Example 40::US10711020, Example 40 Nuclear receptor ROR-gamma [262-507] 62.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382258 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382258&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678979 404851631 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 930954 Cc1ccc(cc1)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)-c1cccnc1)C(=O)[C@H]1CC[C@@H](CC1)C(O)=O InChI=1S/C32H34N2O5S/c1-21-4-12-27(13-5-21)40(38,39)32-16-18-34(30(35)22-6-8-23(9-7-22)31(36)37)29(32)15-11-25-19-24(10-14-28(25)32)26-3-2-17-33-20-26/h2-5,10,12-14,17,19-20,22-23,29H,6-9,11,15-16,18H2,1H3,(H,36,37)/t22-,23-,29?,32? BMUOQNSHNPOGQV-DGJIIMRFSA-N 382261 US10273259, Example 41::US10711020, Example 41 Nuclear receptor ROR-gamma [262-507] 336 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382261 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382261&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678767 404851634 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 930955 Cc1ccc(cc1)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)-c1ccccc1)C(=O)[C@H]1CC[C@@H](CC1)C(O)=O InChI=1S/C33H35NO5S/c1-22-7-15-28(16-8-22)40(38,39)33-19-20-34(31(35)24-9-11-25(12-10-24)32(36)37)30(33)18-14-27-21-26(13-17-29(27)33)23-5-3-2-4-6-23/h2-8,13,15-17,21,24-25,30H,9-12,14,18-20H2,1H3,(H,36,37)/t24-,25-,30?,33? ZJTHUPANPJPSLK-DERABLCZSA-N 382264 US10273259, Example 42::US10711020, Example 42 Nuclear receptor ROR-gamma [262-507] 186 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382264 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382264&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678959 404851637 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 930956 Cc1ccc(cc1)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)[C@@]1(C)CC[C@@H](CC1)C(O)=O InChI=1S/C31H32F7NO5S/c1-18-3-7-22(8-4-18)45(43,44)28-15-16-39(26(42)27(2)13-11-19(12-14-27)25(40)41)24(28)10-5-20-17-21(6-9-23(20)28)29(32,30(33,34)35)31(36,37)38/h3-4,6-9,17,19,24H,5,10-16H2,1-2H3,(H,40,41)/t19-,24?,27-,28? ASMKMWWMAPJCNU-XJNMGFQWSA-N 382265 US10273259, Example 43::US10711020, Example 43 Nuclear receptor ROR-gamma [262-507] 421 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382265 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382265&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678837 404851638 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 930957 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CCC2(C1COc1cc(ccc21)C(O)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(Cl)cc1 InChI=1S/C28H26ClF6NO7S/c29-18-6-8-19(9-7-18)44(41,42)25-11-12-36(23(37)15-1-3-16(4-2-15)24(38)39)22(25)14-43-21-13-17(5-10-20(21)25)26(40,27(30,31)32)28(33,34)35/h5-10,13,15-16,22,40H,1-4,11-12,14H2,(H,38,39)/t15-,16-,22?,25? DXAZIJICDSJYBW-QAXNPQHNSA-N 382266 US10273259, Example 44::US10711020, Example 44 Nuclear receptor ROR-gamma [262-507] 138 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382266 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382266&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678770 404851639 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 930958 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CCC2(C1CCc1cc(ccc21)C(O)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1cccc(Cl)c1 InChI=1S/C29H28ClF6NO6S/c30-20-2-1-3-21(15-20)44(42,43)26-12-13-37(24(38)16-4-6-17(7-5-16)25(39)40)23(26)11-8-18-14-19(9-10-22(18)26)27(41,28(31,32)33)29(34,35)36/h1-3,9-10,14-17,23,41H,4-8,11-13H2,(H,39,40)/t16-,17-,23?,26? GXNYATPJZKFFFV-LRVXPCDCSA-N 382267 US10273259, Example 45::US10711020, Example 45 Nuclear receptor ROR-gamma [262-507] 138 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382267 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382267&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678642 404851640 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931695 Cn1nnc(n1)-c1ccc(cc1)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C29H23F8N5O2S/c1-41-39-25(38-40-41)17-2-8-21(9-3-17)42-15-14-26(45(43,44)22-10-6-20(30)7-11-22)23-12-5-19(16-18(23)4-13-24(26)42)27(31,28(32,33)34)29(35,36)37/h2-3,5-12,16,24H,4,13-15H2,1H3/t24-,26-/m1/s1 YRGRBAUVKSBUAL-AOYPEHQESA-N 383074 US10273259, Example 785::US10711020, Example 785 Nuclear receptor ROR-gamma [262-507] 3199 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383074 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383074&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679255 404852378 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931696 OC(=O)C1(CC1)c1ccc(cc1)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C31H25F8NO4S/c32-21-5-9-23(10-6-21)45(43,44)28-15-16-40(22-7-2-19(3-8-22)27(13-14-27)26(41)42)25(28)12-1-18-17-20(4-11-24(18)28)29(33,30(34,35)36)31(37,38)39/h2-11,17,25H,1,12-16H2,(H,41,42)/t25-,28-/m1/s1 FWGHZTYTFDGARE-LEAFIULHSA-N 383075 US10273259, Example 786::US10711020, Example 786 Nuclear receptor ROR-gamma [262-507] 1441 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383075 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383075&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679179 404852379 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931697 CN(C)S(=O)(=O)c1cccc(c1)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C29H26F8N2O4S2/c1-38(2)45(42,43)23-5-3-4-21(17-23)39-15-14-26(44(40,41)22-10-8-20(30)9-11-22)24-12-7-19(16-18(24)6-13-25(26)39)27(31,28(32,33)34)29(35,36)37/h3-5,7-12,16-17,25H,6,13-15H2,1-2H3/t25-,26-/m1/s1 XKXZXGYMMFLYBM-CLJLJLNGSA-N 383076 US10273259, Example 787::US10711020, Example 787 Nuclear receptor ROR-gamma [262-507] 4311 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383076 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383076&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679287 404852380 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931698 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN(C#N)[C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F InChI=1S/C22H16F8N2O2S/c23-15-3-5-16(6-4-15)35(33,34)19-9-10-32(12-31)18(19)8-1-13-11-14(2-7-17(13)19)20(24,21(25,26)27)22(28,29)30/h2-7,11,18H,1,8-10H2/t18-,19-/m1/s1 BCMPTGHPPKHMIV-RTBURBONSA-N 383077 (3aR,9bR)-9b-((4-fluorophenyl)sulfon)-7-(perfluoropropan-2-yl)-1,2,3a,4,5,9b-hexahydro-3H-benzo[e]indole-3-carbonitrile::US10273259, Example 788::US10711020, Example 788 Nuclear receptor ROR-gamma [262-507] 98.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383077 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383077&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122669246 404852381 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931699 CC(C)(C)OC(=O)N1CC2N(CCC2(c2ccc(cc12)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1)C(=O)[C@H]1CC[C@@H](CC1)C(O)=O InChI=1S/C33H34F8N2O7S/c1-29(2,3)50-28(47)43-17-25-30(51(48,49)22-11-9-21(34)10-12-22,14-15-42(25)26(44)18-4-6-19(7-5-18)27(45)46)23-13-8-20(16-24(23)43)31(35,32(36,37)38)33(39,40)41/h8-13,16,18-19,25H,4-7,14-15,17H2,1-3H3,(H,45,46)/t18-,19-,25?,30? FVIRJSMDLMJNNB-MZYLFTCCSA-N 383078 (1r,4r)-4-(5-(tert-butoxycarbonyl)-9b-((4-fluorophenyl)sulfonyl)-7-(perfluoropropan-2-yl)-2,3,3a,4,5,9b-hexahydro-1H-pyrrolo[2,3-c]quinoline-3-carbonyl)cyclohexane-1-carboxylic acid::US10273259, Example 789::US10711020, Example 789 Nuclear receptor ROR-gamma [262-507] 1866 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383078 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383078&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122669267 404852382 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931700 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CCC2(C1CCc1cc(CC(F)(F)F)ccc21)S(=O)(=O)c1ccc(Cl)cc1 InChI=1S/C28H29ClF3NO5S/c29-21-7-9-22(10-8-21)39(37,38)27-13-14-33(25(34)18-2-4-19(5-3-18)26(35)36)24(27)12-6-20-15-17(1-11-23(20)27)16-28(30,31)32/h1,7-11,15,18-19,24H,2-6,12-14,16H2,(H,35,36)/t18-,19-,24?,27? CJQMXTYGUBQBSQ-QXIWJBPRSA-N 383079 (1r,4r)-4-(9b-((4-chlorophenyl)sulfonyl)-7-(perfluoropropyl)-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]indole-3-carbonyl)cyclohexane-1-carboxylic acid::US10273259, Example 790::US10711020, Example 790 Nuclear receptor ROR-gamma [262-507] 41.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383079 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383079&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 145995616 404852383 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931701 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(F)C(F)F)S(=O)(=O)c1ccc(Cl)cc1 InChI=1S/C28H28ClF4NO5S/c29-21-7-9-22(10-8-21)40(38,39)27-13-14-34(25(35)18-2-4-19(5-3-18)26(36)37)24(27)12-6-20-15-17(1-11-23(20)27)16-33-28(30,31)32/h1,7-11,15-16,18-19,24H,2-6,12-14H2,(H,36,37)/t18-,19-,24?,27? HIIHFQWSLCIKOM-QXIWJBPRSA-N 453826 (1r,4r)-4-(9b-((4-chlorophenyl)sulfonyl)-7-(1,1,2,2-tetrafluoroethyl)-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]indole-3-carbonyl)cyclohexane-1-carboxylic Acid::US10711020, Example 791 Nuclear receptor ROR-gamma [262-507] 78.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=453826 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=453826&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122669051 440969713 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931702 OC(=O)C12CCC(CC1)(CC2)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(cc1)C#N InChI=1S/C32H29F7N2O5S/c33-30(31(34,35)36,32(37,38)39)21-4-7-23-20(17-21)3-8-24-29(23,47(45,46)22-5-1-19(18-40)2-6-22)15-16-41(24)25(42)27-9-12-28(13-10-27,14-11-27)26(43)44/h1-2,4-7,17,24H,3,8-16H2,(H,43,44) OXYFHDCLZCGNPN-UHFFFAOYSA-N 383081 4-(9b-((4-cyanophenyl)sulfonyl)-7-(perfluoropropan-2-yl)-2,3,3a,4,59b-hexahydro-1H-benzo[e]indole-3-carbonyl)bicyclo[2.2.2]octane-1-carboxylic acid::US10273259, Example 792::US10711020, Example 792 Nuclear receptor ROR-gamma [262-507] 186 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383081 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383081&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122669179 404852385 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931703 CN(C)c1ccc(cc1)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C12CCC(CC1)(CC2)C(O)=O InChI=1S/C33H35F7N2O5S/c1-41(2)22-5-7-23(8-6-22)48(46,47)30-17-18-42(26(43)28-11-14-29(15-12-28,16-13-28)27(44)45)25(30)10-3-20-19-21(4-9-24(20)30)31(34,32(35,36)37)33(38,39)40/h4-9,19,25H,3,10-18H2,1-2H3,(H,44,45) VFPOHKRGMQNWSJ-UHFFFAOYSA-N 383082 4-(9b-((4-(dimethylamino)phenyl)sulfonyl)-7-(perfluoropropan-2-yl)-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]indole-3-carbonyl)bicyclo[2.2.2]octane-1-carboxylic acid::US10273259, Example 793::US10711020, Example 793 Nuclear receptor ROR-gamma [262-507] 398 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383082 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383082&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122669116 404852386 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931704 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(cc1)-c1cnoc1 InChI=1S/C32H29F7N2O6S/c33-30(31(34,35)36,32(37,38)39)23-8-11-25-21(15-23)7-12-26-29(25,13-14-41(26)27(42)19-1-3-20(4-2-19)28(43)44)48(45,46)24-9-5-18(6-10-24)22-16-40-47-17-22/h5-6,8-11,15-17,19-20,26H,1-4,7,12-14H2,(H,43,44)/t19-,20-,26?,29? QQGUOZSVFBDLOO-IWULTPLFSA-N 383083 (1r,4r)-4-(9b-((4-(isoxazol-4-yl)phenyl)sulfonyl)-7-(perfluoropropan-2-yl)-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]indole-3-carbonyl)cyclohexane-1-carboxylic acid::US10273259, Example 794::US10711020, Example 794 Nuclear receptor ROR-gamma [262-507] 566 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383083 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383083&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122669056 404852387 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931705 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(cc1)-c1cn[nH]c1 383084 (1r,4r)-4-(9b-((4-(1H-pyrazol-4-yl)phenyl)sulfonyl)-7-(perfluoropropan-2-yl)-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]indole-3-carbonyl)cyclohexane-1-carboxylic acid::US10273259, Example 795::US10711020, Example 795 Nuclear receptor ROR-gamma [262-507] 2382 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383084 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383084&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122669175 404852388 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931706 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1cccc(c1)C1CC1 InChI=1S/C32H32F7NO5S/c33-30(31(34,35)36,32(37,38)39)23-11-12-25-22(16-23)10-13-26-29(25,46(44,45)24-3-1-2-21(17-24)18-4-5-18)14-15-40(26)27(41)19-6-8-20(9-7-19)28(42)43/h1-3,11-12,16-20,26H,4-10,13-15H2,(H,42,43)/t19-,20-,26?,29? FFVQQGOYYNBWJR-IWULTPLFSA-N 383085 (1r,4r)-4-(9b-((3-cyclopropylphenyl)sulfon)-7-(perfluoropropan-2-yl)-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]indole-3-carbonyl)cyclohexane-1-carboxylic acid::US10273259, Example 796::US10711020, Example 796 Nuclear receptor ROR-gamma [262-507] 100.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383085 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383085&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122669082 404852389 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931707 CC(C)c1cccc(c1)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)[C@H]1CC[C@@H](CC1)C(O)=O InChI=1S/C32H34F7NO5S/c1-18(2)21-4-3-5-24(17-21)46(44,45)29-14-15-40(27(41)19-6-8-20(9-7-19)28(42)43)26(29)13-10-22-16-23(11-12-25(22)29)30(33,31(34,35)36)32(37,38)39/h3-5,11-12,16-20,26H,6-10,13-15H2,1-2H3,(H,42,43)/t19-,20-,26?,29? KZUNTLQUEAKZJR-IWULTPLFSA-N 383086 US10273259, Example 797::US10711020, Example 797 Nuclear receptor ROR-gamma [262-507] 136 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383086 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383086&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679169 404852390 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931708 CC(C)(C)c1cccc(c1)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)[C@H]1CC[C@@H](CC1)C(O)=O InChI=1S/C33H36F7NO5S/c1-29(2,3)22-5-4-6-24(18-22)47(45,46)30-15-16-41(27(42)19-7-9-20(10-8-19)28(43)44)26(30)14-11-21-17-23(12-13-25(21)30)31(34,32(35,36)37)33(38,39)40/h4-6,12-13,17-20,26H,7-11,14-16H2,1-3H3,(H,43,44)/t19-,20-,26?,30? ZQQMASTWINYCKW-XZJQCRQJSA-N 383087 US10273259, Example 798::US10711020, Example 798 Nuclear receptor ROR-gamma [262-507] 167 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383087 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383087&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679155 404852391 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931709 C[C@@]1(CC[C@@H](CC1)C(N)=O)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C30H30F8N2O4S/c1-26(12-10-17(11-13-26)24(39)41)25(42)40-15-14-27(45(43,44)21-6-4-20(31)5-7-21)22-8-3-19(16-18(22)2-9-23(27)40)28(32,29(33,34)35)30(36,37)38/h3-8,16-17,23H,2,9-15H2,1H3,(H2,39,41)/t17-,23-,26-,27-/m1/s1 ONFZNJMYTDFRQY-ZKPUSUNFSA-N 383088 (1R,4r)-4-((3aR,9bR)-9b-((4-fluorophenyl)sulfonyl)-7-(perfluoropropan-2-yl)-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]indole-3-carbonyl)-4-methylcyclohexanecarboxamide::US10273259, Example 799::US10711020, Example 799 Nuclear receptor ROR-gamma [262-507] 151 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383088 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383088&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122669251 404852392 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931710 NC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C29H28F8N2O4S/c30-20-7-9-21(10-8-20)44(42,43)26-13-14-39(25(41)17-3-1-16(2-4-17)24(38)40)23(26)12-5-18-15-19(6-11-22(18)26)27(31,28(32,33)34)29(35,36)37/h6-11,15-17,23H,1-5,12-14H2,(H2,38,40)/t16-,17-,23-,26-/m1/s1 PNTPXUODWXXURV-NIULTJEISA-N 383089 US10273259, Example 800::US10711020, Example 800 Nuclear receptor ROR-gamma [262-507] 612 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383089 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383089&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678818 404852393 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931711 NC(=O)C12CCC(CC1)(CC2)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C31H30F8N2O4S/c32-20-3-5-21(6-4-20)46(44,45)28-15-16-41(25(43)27-12-9-26(10-13-27,11-14-27)24(40)42)23(28)8-1-18-17-19(2-7-22(18)28)29(33,30(34,35)36)31(37,38)39/h2-7,17,23H,1,8-16H2,(H2,40,42)/t23-,26?,27?,28-/m1/s1 JSBIURSSLBILKU-LJJHVHFXSA-N 383090 US10273259, Example 801::US10711020, Example 801 Nuclear receptor ROR-gamma [262-507] 23.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383090 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383090&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678798 404852394 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931712 OC(=O)CNC(=O)CN1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C25H22F8N2O5S/c26-16-3-5-17(6-4-16)41(39,40)22-9-10-35(13-20(36)34-12-21(37)38)19(22)8-1-14-11-15(2-7-18(14)22)23(27,24(28,29)30)25(31,32)33/h2-7,11,19H,1,8-10,12-13H2,(H,34,36)(H,37,38)/t19-,22-/m1/s1 XUMHQYDIOXEKGF-DENIHFKCSA-N 383091 (2-((3aR,9bR)-9b-((4-fluorophenyl)sulfonyl)-7-(perfluoropropan-2-yl)-1,2,3a,4,5,9b-hexahydro-3H-benzo[e]indol-3-yl)acetyl)glycine::US10273259, Example 802::US10711020, Example 802 Nuclear receptor ROR-gamma [262-507] 45.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383091 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383091&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122669102 404852395 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931713 CC(=O)N1[C@H]2CC[C@@H]1C[C@H](C2)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C31H30F8N2O4S/c1-17(42)41-22-6-7-23(41)16-19(15-22)27(43)40-13-12-28(46(44,45)24-8-4-21(32)5-9-24)25-10-3-20(14-18(25)2-11-26(28)40)29(33,30(34,35)36)31(37,38)39/h3-5,8-10,14,19,22-23,26H,2,6-7,11-13,15-16H2,1H3/t19-,22-,23+,26-,28-/m1/s1 XOTKCPPJYNDQNN-GBBRFOGASA-N 383092 1-((1R,3s,5S)-3-((3aR,9bR)-9b-((4-fluorophenyl)sulfon-7-(perfluoropropan-2-yl)-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]indole-3-carbonyl)-8-azabicyclo[3.2.1]octan-8-yl)ethan-1-one::US10273259, Example 803::US10711020, Example 803 Nuclear receptor ROR-gamma [262-507] 73.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383092 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383092&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122669050 404852396 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931714 CC1(CCN(CC1)S(C)(=O)=O)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C29H30F8N2O5S2/c1-25(11-14-38(15-12-25)45(2,41)42)24(40)39-16-13-26(46(43,44)21-7-5-20(30)6-8-21)22-9-4-19(17-18(22)3-10-23(26)39)27(31,28(32,33)34)29(35,36)37/h4-9,17,23H,3,10-16H2,1-2H3/t23-,26-/m1/s1 HMQAYZVGFYBODV-ZEQKJWHPSA-N 383093 ((3aR,9bR)-9b-((4-fluorophenyl)sulfonyl)-7-(perfluoropropan-2-yl)-1,2,3a,4,5,9b-hexahydro-3H-benzo[e]indol-3-yl)(4-methyl-1-(methylsulfonyl)piperidin-4-yl)methanone::US10273259, Example 804::US10711020, Example 804 Nuclear receptor ROR-gamma [262-507] 88.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383093 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383093&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122669204 404852397 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931715 CS(=O)(=O)N1CC[C@H](CC(=O)N2CC[C@@]3([C@H]2CCc2cc(ccc32)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c2ccc(F)cc2)C1 InChI=1S/C28H28F8N2O5S2/c1-44(40,41)37-12-10-17(16-37)14-24(39)38-13-11-25(45(42,43)21-6-4-20(29)5-7-21)22-8-3-19(15-18(22)2-9-23(25)38)26(30,27(31,32)33)28(34,35)36/h3-8,15,17,23H,2,9-14,16H2,1H3/t17-,23-,25-/m1/s1 JVGBYMCNHUKIJC-WQWSHVPRSA-N 383094 US10273259, Example 805::US10711020, Example 805 Nuclear receptor ROR-gamma [262-507] 88.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383094 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383094&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679193 404852398 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931716 CC(=O)N1CC[C@H](CC(=O)N2CC[C@@]3([C@H]2CCc2cc(ccc32)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c2ccc(F)cc2)C1 InChI=1S/C29H28F8N2O4S/c1-17(40)38-12-10-18(16-38)14-25(41)39-13-11-26(44(42,43)22-6-4-21(30)5-7-22)23-8-3-20(15-19(23)2-9-24(26)39)27(31,28(32,33)34)29(35,36)37/h3-8,15,18,24H,2,9-14,16H2,1H3/t18-,24-,26-/m1/s1 YPQKOUHFNCTHTI-DETVKUJNSA-N 383095 US10273259, Example 806::US10711020, Example 806 Nuclear receptor ROR-gamma [262-507] 145 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383095 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383095&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678933 404852399 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931717 CS(=O)(=O)N1CC[C@@H](CC(=O)N2CC[C@@]3([C@H]2CCc2cc(ccc32)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c2ccc(F)cc2)C1 InChI=1S/C28H28F8N2O5S2/c1-44(40,41)37-12-10-17(16-37)14-24(39)38-13-11-25(45(42,43)21-6-4-20(29)5-7-21)22-8-3-19(15-18(22)2-9-23(25)38)26(30,27(31,32)33)28(34,35)36/h3-8,15,17,23H,2,9-14,16H2,1H3/t17-,23+,25+/m0/s1 JVGBYMCNHUKIJC-FIMBPPNMSA-N 383096 US10273259, Example 807::US10711020, Example 807 Nuclear receptor ROR-gamma [262-507] 283 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383096 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383096&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679270 404852400 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931718 CC(=O)N1CC[C@@H](CC(=O)N2CC[C@@]3([C@H]2CCc2cc(ccc32)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c2ccc(F)cc2)C1 InChI=1S/C29H28F8N2O4S/c1-17(40)38-12-10-18(16-38)14-25(41)39-13-11-26(44(42,43)22-6-4-21(30)5-7-22)23-8-3-20(15-19(23)2-9-24(26)39)27(31,28(32,33)34)29(35,36)37/h3-8,15,18,24H,2,9-14,16H2,1H3/t18-,24+,26+/m0/s1 YPQKOUHFNCTHTI-GJECAEJISA-N 383097 US10273259, Example 808::US10711020, Example 808 Nuclear receptor ROR-gamma [262-507] 107 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383097 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383097&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679297 404852401 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931719 CNC(=O)N1CCC(O)(CC1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C29H29F8N3O5S/c1-38-24(42)39-13-10-25(43,11-14-39)23(41)40-15-12-26(46(44,45)20-6-4-19(30)5-7-20)21-8-3-18(16-17(21)2-9-22(26)40)27(31,28(32,33)34)29(35,36)37/h3-8,16,22,43H,2,9-15H2,1H3,(H,38,42)/t22-,26-/m1/s1 XFOCXZOXBPQBPJ-ATIYNZHBSA-N 383098 US10273259, Example 809::US10711020, Example 809 Nuclear receptor ROR-gamma [262-507] 25.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383098 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383098&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679189 404852402 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931720 CC(=O)N1CCC(O)(CC1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C29H28F8N2O5S/c1-17(40)38-13-10-25(42,11-14-38)24(41)39-15-12-26(45(43,44)21-6-4-20(30)5-7-21)22-8-3-19(16-18(22)2-9-23(26)39)27(31,28(32,33)34)29(35,36)37/h3-8,16,23,42H,2,9-15H2,1H3/t23-,26-/m1/s1 KRNPISDXRCLWSC-ZEQKJWHPSA-N 383099 US10273259, Example 810::US10711020, Example 810 Nuclear receptor ROR-gamma [262-507] 50.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383099 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383099&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678813 404852403 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931721 CS(=O)(=O)N1CCC(O)(CC1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H28F8N2O6S2/c1-45(41,42)37-13-10-24(40,11-14-37)23(39)38-15-12-25(46(43,44)20-6-4-19(29)5-7-20)21-8-3-18(16-17(21)2-9-22(25)38)26(30,27(31,32)33)28(34,35)36/h3-8,16,22,40H,2,9-15H2,1H3/t22-,25-/m1/s1 GSKNAEWYNISDFT-RCZVLFRGSA-N 383100 US10273259, Example 811::US10711020, Example 811 Nuclear receptor ROR-gamma [262-507] 23.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383100 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383100&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679153 404852404 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931722 CNC(=O)N1CCC(CC1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C29H29F8N3O4S/c1-38-25(42)39-13-10-17(11-14-39)24(41)40-15-12-26(45(43,44)21-6-4-20(30)5-7-21)22-8-3-19(16-18(22)2-9-23(26)40)27(31,28(32,33)34)29(35,36)37/h3-8,16-17,23H,2,9-15H2,1H3,(H,38,42)/t23-,26-/m1/s1 PJIGGRYGFXGPOU-ZEQKJWHPSA-N 383101 US10273259, Example 812::US10711020, Example 812 Nuclear receptor ROR-gamma [262-507] 195 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383101 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383101&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678777 404852405 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931723 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1CCN(CC1)C#N InChI=1S/C28H25F8N3O3S/c29-20-3-5-21(6-4-20)43(41,42)25-11-14-39(24(40)17-9-12-38(16-37)13-10-17)23(25)8-1-18-15-19(2-7-22(18)25)26(30,27(31,32)33)28(34,35)36/h2-7,15,17,23H,1,8-14H2/t23-,25-/m1/s1 YQTJHRVUUFXQJE-ILBGXUMGSA-N 383102 4-((3a,9bR)-9b-((4-fluorophenyl)sulfonyl)-7-(perfluoropropan-2-yl)-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]indole-3-carbonyl)piperidine-1-carbonitrile::US10273259, Example 813::US10711020, Example 813 Nuclear receptor ROR-gamma [262-507] 115 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383102 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383102&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122669112 404852406 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931724 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1CCN(CC1)C1COC1 InChI=1S/C30H30F8N2O4S/c31-21-3-5-23(6-4-21)45(42,43)27-11-14-40(26(41)18-9-12-39(13-10-18)22-16-44-17-22)25(27)8-1-19-15-20(2-7-24(19)27)28(32,29(33,34)35)30(36,37)38/h2-7,15,18,22,25H,1,8-14,16-17H2/t25-,27-/m1/s1 NZJVRFQYGIPLQK-XNMGPUDCSA-N 383103 ((3aR,9bR)-9b-((4-fluorophenyl)sulfonyl)-7-(perfluoropropan-2-yl)-1,2,3a,4,5,9b-hexahydro-3H-benzo[e]indol-3-yl)(1-(oxetan-3-yl)piperidin-4-yl)methanone::US10273259, Example 814::US10711020, Example 814 Nuclear receptor ROR-gamma [262-507] 125 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383103 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383103&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122669219 404852407 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931725 OC1(CCN(CC1)C1COC1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C30H30F8N2O5S/c31-20-3-5-22(6-4-20)46(43,44)27-11-14-40(25(41)26(42)9-12-39(13-10-26)21-16-45-17-21)24(27)8-1-18-15-19(2-7-23(18)27)28(32,29(33,34)35)30(36,37)38/h2-7,15,21,24,42H,1,8-14,16-17H2/t24-,27-/m1/s1 BDFQXHHQFBKLKW-SHQCIBLASA-N 383104 US10273259, Example 815::US10711020, Example 815 Nuclear receptor ROR-gamma [262-507] 18.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383104 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383104&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679299 404852408 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931726 FC(F)(F)C(F)(c1ccc2c(CCC3N(CCC23S(=O)(=O)c2ccc(Cl)cc2)C(=O)C2CCN(CC2)C2COC2)c1)C(F)(F)F InChI=1S/C30H30ClF7N2O4S/c31-21-3-5-23(6-4-21)45(42,43)27-11-14-40(26(41)18-9-12-39(13-10-18)22-16-44-17-22)25(27)8-1-19-15-20(2-7-24(19)27)28(32,29(33,34)35)30(36,37)38/h2-7,15,18,22,25H,1,8-14,16-17H2 DNCYFVCXNBPWBR-UHFFFAOYSA-N 383105 US10273259, Example 816::US10711020, Example 816 Nuclear receptor ROR-gamma [262-507] 105 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383105 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383105&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679184 404852409 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931727 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)[C@H]1C[C@@H]2CC[C@H](C1)N2C1COC1 InChI=1S/C32H32F8N2O4S/c33-21-3-7-25(8-4-21)47(44,45)29-11-12-41(28(43)19-14-22-5-6-23(15-19)42(22)24-16-46-17-24)27(29)10-1-18-13-20(2-9-26(18)29)30(34,31(35,36)37)32(38,39)40/h2-4,7-9,13,19,22-24,27H,1,5-6,10-12,14-17H2/t19-,22-,23+,27-,29-/m1/s1 XCZUUBDKYSLWSI-VYYHNUKQSA-N 383106 US10273259, Example 817::US10711020, Example 817 Nuclear receptor ROR-gamma [262-507] 601 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383106 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383106&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679123 404852410 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931728 C[C@H]1CN(CCN1CC(O)=O)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C29H29F8N3O5S/c1-17-15-39(13-12-38(17)16-24(41)42)25(43)40-11-10-26(46(44,45)21-6-4-20(30)5-7-21)22-8-3-19(14-18(22)2-9-23(26)40)27(31,28(32,33)34)29(35,36)37/h3-8,14,17,23H,2,9-13,15-16H2,1H3,(H,41,42)/t17-,23+,26+/m0/s1 AZOCQYRFZPNTLU-UIIQVKDUSA-N 383107 2-((S)-4-((3aR,9bR)-9b-((4-fluorophenyl)sulfonyl)-7-perfluoropropan-2-yl)-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]indole-3-carbonyl)-2-methylpiperazin-1-yl)acetic acid::US10273259, Example 818::US10711020, Example 818 Nuclear receptor ROR-gamma [262-507] 848 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383107 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383107&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122669154 404852411 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931729 CC(CO)(CO)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C26H25F8NO5S/c1-22(13-36,14-37)21(38)35-11-10-23(41(39,40)18-6-4-17(27)5-7-18)19-8-3-16(12-15(19)2-9-20(23)35)24(28,25(29,30)31)26(32,33)34/h3-8,12,20,36-37H,2,9-11,13-14H2,1H3/t20-,23-/m1/s1 SJISJDDTPYIHDW-NFBKMPQASA-N 383108 1-((3aR,9bR)-9b-((4-fluorophenyl)sulfonyl)-7-(perfluoropropan-2-yl)-1,2,3a,4,5,9b-hexahydro-3H-benzo[e]indol-3-yl)-3-hydroxy-2-(hydroxymethyl)-2-methylpropan-1-one::US10273259, Example 819::US10711020, Example 819 Nuclear receptor ROR-gamma [262-507] 29.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383108 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383108&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122669151 404852412 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931730 CC1(COP(O)(=O)OC1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C26H24F8NO7PS/c1-22(13-41-43(37,38)42-14-22)21(36)35-11-10-23(44(39,40)18-6-4-17(27)5-7-18)19-8-3-16(12-15(19)2-9-20(23)35)24(28,25(29,30)31)26(32,33)34/h3-8,12,20H,2,9-11,13-14H2,1H3,(H,37,38)/t20-,23-/m1/s1 XRBKBRHJDSCDDG-NFBKMPQASA-N 383109 ((3aR,9bR)-9b-((4-fluorophenyl)sulfonyl)-7-(perfluoropropan-2-yl)-1,2,3a,4,5,9b-hexahydro-3H-benzo[e]indol-3-yl)(2-hydroxy-5-methyl-2-oxido-1,3,2-dioxaphosphinan-5-yl)methanone::US10273259, Example 820::US10711020, Example 820 Nuclear receptor ROR-gamma [262-507] 47.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383109 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383109&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122669278 404852413 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931731 CC1(COP(N)(=O)OC1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C26H25F8N2O6PS/c1-22(13-41-43(35,38)42-14-22)21(37)36-11-10-23(44(39,40)18-6-4-17(27)5-7-18)19-8-3-16(12-15(19)2-9-20(23)36)24(28,25(29,30)31)26(32,33)34/h3-8,12,20H,2,9-11,13-14H2,1H3,(H2,35,38)/t20-,22?,23-,43?/m1/s1 FQJBALRISFYQFS-YPCLUYDESA-N 383110 (2-amino-5-methyl-2-oxido-1,3,2-dioxaphosphinan-5-yl)((3aR,9bR)-9b-((4-fluorophenyl)sulfonyl)-7-(perfluoropropan-2-yl)-1,2,3a,4,5,9b-hexahydro-3H-benzo[e]indol-3-yl)methanone::US10273259, Example 821::US10711020, Example 821 Nuclear receptor ROR-gamma [262-507] 18.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383110 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383110&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122669061 404852414 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931732 CC1(COP(C)(=O)OC1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C27H26F8NO6PS/c1-23(14-41-43(2,38)42-15-23)22(37)36-12-11-24(44(39,40)19-7-5-18(28)6-8-19)20-9-4-17(13-16(20)3-10-21(24)36)25(29,26(30,31)32)27(33,34)35/h4-9,13,21H,3,10-12,14-15H2,1-2H3/t21-,23?,24-,43?/m1/s1 ZJYVFLYPUYHVNV-WJSCHIDKSA-N 383111 (2,5-dimethyl-2-oxido-1,3,2-dioxaphosphinan-5-yl)((3aR,9bR)-9b-((4-fluorophenyl)sulfonyl)-7-(perfluoropropan-2-yl)-1,2,3a,4,5,9b-hexahydro-3H-benzo[e]indol-3-yl)methanone (Two Homochiral Isomers)::US10273259, Example 822::US10273259, Example 823::US10711020, Example 823 Nuclear receptor ROR-gamma [262-507] 49.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383111 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383111&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122669172 404852415 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931733 CC1(COP(C)(=O)OC1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C27H26F8NO6PS/c1-23(14-41-43(2,38)42-15-23)22(37)36-12-11-24(44(39,40)19-7-5-18(28)6-8-19)20-9-4-17(13-16(20)3-10-21(24)36)25(29,26(30,31)32)27(33,34)35/h4-9,13,21H,3,10-12,14-15H2,1-2H3/t21-,23?,24-,43?/m1/s1 ZJYVFLYPUYHVNV-WJSCHIDKSA-N 383111 (2,5-dimethyl-2-oxido-1,3,2-dioxaphosphinan-5-yl)((3aR,9bR)-9b-((4-fluorophenyl)sulfonyl)-7-(perfluoropropan-2-yl)-1,2,3a,4,5,9b-hexahydro-3H-benzo[e]indol-3-yl)methanone (Two Homochiral Isomers)::US10273259, Example 822::US10273259, Example 823::US10711020, Example 823 Nuclear receptor ROR-gamma [262-507] 39.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383111 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383111&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122669172 404852415 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931734 OC(=O)c1ccc(cc1F)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C29H20F9NO5S/c30-18-4-6-19(7-5-18)45(43,44)26-11-12-39(24(40)16-1-8-20(25(41)42)22(31)14-16)23(26)10-2-15-13-17(3-9-21(15)26)27(32,28(33,34)35)29(36,37)38/h1,3-9,13-14,23H,2,10-12H2,(H,41,42)/t23-,26-/m1/s1 XIACOCZEICGICV-ZEQKJWHPSA-N 383113 2-fluoro-4-((3aR,9bR)-9b-((4-fluorophenyl)sulfonyl)-7-(perfluoropropan-2-yl)-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]indole-3-carbonyl)benzamide and 2-fluoro-4-((3aR,9bR)-9b-((4-fluorophenyl)sulfonyl)-7-(perfluoropropan-2-yl)-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]indole-3-carbonyl)benzoic acid::US10273259, Example 824::US10273259, Example 825::US10711020, Example 825 Nuclear receptor ROR-gamma [262-507] 142 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383113 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383113&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122669083 404852416 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931735 OC(=O)c1ccc(cc1F)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C29H20F9NO5S/c30-18-4-6-19(7-5-18)45(43,44)26-11-12-39(24(40)16-1-8-20(25(41)42)22(31)14-16)23(26)10-2-15-13-17(3-9-21(15)26)27(32,28(33,34)35)29(36,37)38/h1,3-9,13-14,23H,2,10-12H2,(H,41,42)/t23-,26-/m1/s1 XIACOCZEICGICV-ZEQKJWHPSA-N 383113 2-fluoro-4-((3aR,9bR)-9b-((4-fluorophenyl)sulfonyl)-7-(perfluoropropan-2-yl)-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]indole-3-carbonyl)benzamide and 2-fluoro-4-((3aR,9bR)-9b-((4-fluorophenyl)sulfonyl)-7-(perfluoropropan-2-yl)-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]indole-3-carbonyl)benzoic acid::US10273259, Example 824::US10273259, Example 825::US10711020, Example 825 Nuclear receptor ROR-gamma [262-507] 489 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383113 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383113&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122669083 404852416 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931736 OC(C(O)=O)c1ccc(cc1Cl)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C30H22ClF8NO6S/c31-22-14-16(1-8-20(22)24(41)26(43)44)25(42)40-12-11-27(47(45,46)19-6-4-18(32)5-7-19)21-9-3-17(13-15(21)2-10-23(27)40)28(33,29(34,35)36)30(37,38)39/h1,3-9,13-14,23-24,41H,2,10-12H2,(H,43,44)/t23-,24?,27-/m1/s1 ZKYJEQPHVBKIEX-GJQXLMDHSA-N 383115 (RS)-2-(2-chloro-4-((3aR,9bR)-9b-((4-fluorophenyl)sulfonyl)-7-(perfluoropropan-2-v)-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]indole-3-carbonyl)phenyl)-2-hydroxyacetic acid::US10273259, Example 826::US10711020, Example 826 Nuclear receptor ROR-gamma [262-507] 1086 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383115 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383115&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122669093 404852417 C02929 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931737 OC(C(O)=O)c1ccc(cc1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C30H23F8NO6S/c31-20-7-9-21(10-8-20)46(44,45)27-13-14-39(25(41)17-3-1-16(2-4-17)24(40)26(42)43)23(27)12-5-18-15-19(6-11-22(18)27)28(32,29(33,34)35)30(36,37)38/h1-4,6-11,15,23-24,40H,5,12-14H2,(H,42,43)/t23-,24?,27-/m1/s1 SGMCRRZFRGAWRB-GJQXLMDHSA-N 383116 (RS)-2-(4-((3aR,9bR)-9b-((4-fluorophenyl)sulfonyl)-7-(perfluoropropan-2-yl)-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]indole-3-carbonyl)phenyl)-2-hydroxyacetic acid::US10273259, Example 827::US10711020, Example 827 Nuclear receptor ROR-gamma [262-507] 78.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383116 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383116&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122669263 404852418 C02929 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931738 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1(F)CCS(=O)(=O)CC1 InChI=1S/C27H24F9NO5S2/c28-18-3-5-19(6-4-18)44(41,42)24-9-12-37(22(38)23(29)10-13-43(39,40)14-11-23)21(24)8-1-16-15-17(2-7-20(16)24)25(30,26(31,32)33)27(34,35)36/h2-7,15,21H,1,8-14H2/t21-,24-/m1/s1 LLGWTSRFQCMJHP-ZJSXRUAMSA-N 383117 (4-fluoro-1,1-dioxidotetrahydro-2H-thiopyran-4-yl)((3aR,9bR)-9b-((4-fluorophenyl)sulfonyl)-7-(perfluoropropan-2-yl)-1,2,3a,4,5,9b-hexahydro-3H-benzo[e]indol-3-yl)methanone::US10273259, Example 828::US10711020, Example 828 Nuclear receptor ROR-gamma [262-507] 8.00 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383117 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383117&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122669282 404852419 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931739 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1(F)CCOCC1 InChI=1S/C27H24F9NO4S/c28-18-3-5-19(6-4-18)42(39,40)24-9-12-37(22(38)23(29)10-13-41-14-11-23)21(24)8-1-16-15-17(2-7-20(16)24)25(30,26(31,32)33)27(34,35)36/h2-7,15,21H,1,8-14H2/t21-,24-/m1/s1 GBIHFDAXNUDWEE-ZJSXRUAMSA-N 383118 ((3aR,9bR)-9b-((4-fluorophenyl)sulfonyl)-7-(perfluoropropan-2-yl)-1,2,3a,4,5,9b-hexahydro-3H-benzo[e]indol-3-yl)(4-fluorotetrahydro-2H-pyran-4-yl)methanone::US10273259, Example 829::US10711020, Example 829 Nuclear receptor ROR-gamma [262-507] 47.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383118 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383118&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122669095 404852420 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931740 C[C@H]1CC(CC[C@H]1C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1cccc(F)c1)C(O)=O InChI=1S/C30H29F8NO5S/c1-16-13-18(26(41)42)5-8-22(16)25(40)39-12-11-27(45(43,44)21-4-2-3-20(31)15-21)23-9-7-19(14-17(23)6-10-24(27)39)28(32,29(33,34)35)30(36,37)38/h2-4,7,9,14-16,18,22,24H,5-6,8,10-13H2,1H3,(H,41,42)/t16-,18?,22+,24?,27?/m0/s1 YMYVBTYBEJRHKZ-PEZFPZIYSA-N 453865 (3S,4R)-4-(9b-((3-fluorophenyl)sulfonyl)-7-(perfluoropropan-2-yl)-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]indole-3-carbonyl)-3-methylcyclohexane-1-carboxylic Acid::US10711020, Example 830 Nuclear receptor ROR-gamma [262-507] 32.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=453865 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=453865&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122669214 440969749 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931741 C[C@H]1CC(CC[C@H]1C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1)C(O)=O InChI=1S/C30H29F8NO5S/c1-16-14-18(26(41)42)2-9-22(16)25(40)39-13-12-27(45(43,44)21-7-5-20(31)6-8-21)23-10-4-19(15-17(23)3-11-24(27)39)28(32,29(33,34)35)30(36,37)38/h4-8,10,15-16,18,22,24H,2-3,9,11-14H2,1H3,(H,41,42)/t16-,18?,22+,24+,27+/m0/s1 JQORWGARJVSRBA-UFHIEMDVSA-N 383120 (3S,4R)-4-((3aR,9bR)-9b-((4-fluorophenyl)sulfonyl)-7-(perfluoropropan-2-yl)-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]indole-3-carbonyl)-3-methylcyclohexane-1-carboxylic acid::US10273259, Example 831::US10711020, Example 831 Nuclear receptor ROR-gamma [262-507] 93.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383120 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383120&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122669119 404852422 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931742 C[C@@H]1CC(CC[C@H]1C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1)C(O)=O InChI=1S/C30H29F8NO5S/c1-16-14-18(26(41)42)2-9-22(16)25(40)39-13-12-27(45(43,44)21-7-5-20(31)6-8-21)23-10-4-19(15-17(23)3-11-24(27)39)28(32,29(33,34)35)30(36,37)38/h4-8,10,15-16,18,22,24H,2-3,9,11-14H2,1H3,(H,41,42)/t16-,18?,22-,24-,27-/m1/s1 JQORWGARJVSRBA-FXRNFHIUSA-N 383121 (3R,4R)-4-((3aR,9bR)-9b-((4-fluorophenyl)sulfonyl)-7-(perfluoropropan-2-yl)-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]indole-3-carbonyl)-3-methylcyclohexane-1-carboxylic acid::US10273259, Example 832::US10711020, Example 832 Nuclear receptor ROR-gamma [262-507] 209 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383121 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383121&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122669236 404852423 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931743 C[C@H]1CC(O)CC[C@H]1C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1cccc(F)c1 InChI=1S/C29H29F8NO4S/c1-16-13-20(39)7-8-22(16)25(40)38-12-11-26(43(41,42)21-4-2-3-19(30)15-21)23-9-6-18(14-17(23)5-10-24(26)38)27(31,28(32,33)34)29(35,36)37/h2-4,6,9,14-16,20,22,24,39H,5,7-8,10-13H2,1H3/t16-,20?,22+,24?,26?/m0/s1 FFZHKKVFUNSGEG-QXUMJZPISA-N 383122 (9b-((3-fluorophenyl)sulfonyl)-7-(perfluoropropan-2-yl)-1,2,3a,4,5,9b-hexahydro-3H-benzo[e]indol-3-yl)((1R,2S)-4-hydroxy-2-methylcyclohexyl)methanone::US10273259, Example 833::US10711020, Example 833 Nuclear receptor ROR-gamma [262-507] 74.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383122 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383122&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122669087 404852424 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 930959 FC(F)(F)C(F)(c1ccc2c(OCC3N(CCC23S(=O)(=O)c2ccc(Cl)cc2)C(=O)C2CCS(=O)(=O)CC2)c1)C(F)(F)F InChI=1S/C26H23ClF7NO6S2/c27-17-2-4-18(5-3-17)43(39,40)23-9-10-35(22(36)15-7-11-42(37,38)12-8-15)21(23)14-41-20-13-16(1-6-19(20)23)24(28,25(29,30)31)26(32,33)34/h1-6,13,15,21H,7-12,14H2 VVPMBXSVZJBHEX-UHFFFAOYSA-N 382272 US10273259, Example 46::US10711020, Example 46 Nuclear receptor ROR-gamma [262-507] 111 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382272 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382272&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678567 404851645 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 930960 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CCC2(C1COc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(Cl)cc1 InChI=1S/C28H25ClF7NO6S/c29-18-6-8-19(9-7-18)44(41,42)25-11-12-37(23(38)15-1-3-16(4-2-15)24(39)40)22(25)14-43-21-13-17(5-10-20(21)25)26(30,27(31,32)33)28(34,35)36/h5-10,13,15-16,22H,1-4,11-12,14H2,(H,39,40)/t15-,16-,22?,25? VCXVCISBJCUPPR-QAXNPQHNSA-N 382276 US10273259, Example 47::US10711020, Example 47 Nuclear receptor ROR-gamma [262-507] 130 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382276 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382276&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678962 404851649 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 930961 CC(=O)N1CCC(CC1)C(=O)N1CCC2(C1COc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(Cl)cc1 InChI=1S/C28H26ClF7N2O5S/c1-16(39)37-11-8-17(9-12-37)24(40)38-13-10-25(44(41,42)20-5-3-19(29)4-6-20)21-7-2-18(14-22(21)43-15-23(25)38)26(30,27(31,32)33)28(34,35)36/h2-7,14,17,23H,8-13,15H2,1H3 UYNWLHITYFAZRB-UHFFFAOYSA-N 382279 US10273259, Example 48::US10711020, Example 48 Nuclear receptor ROR-gamma [262-507] 30.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382279 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382279&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678652 404851652 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 930962 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccccc1 InChI=1S/C29H28F7NO5S/c30-27(28(31,32)33,29(34,35)36)20-11-12-22-19(16-20)10-13-23-26(22,43(41,42)21-4-2-1-3-5-21)14-15-37(23)24(38)17-6-8-18(9-7-17)25(39)40/h1-5,11-12,16-18,23H,6-10,13-15H2,(H,39,40)/t17-,18-,23-,26-/m1/s1 SXKKMGOPECZXNY-JJMBJGOUSA-N 382280 US10273259, Example 49::US10711020, Example 49 Nuclear receptor ROR-gamma [262-507] 59.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382280 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382280&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678983 404851653 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 930963 CC(=O)N1CCC(CC1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccccc1 InChI=1S/C29H29F7N2O4S/c1-18(39)37-14-11-19(12-15-37)25(40)38-16-13-26(43(41,42)22-5-3-2-4-6-22)23-9-8-21(17-20(23)7-10-24(26)38)27(30,28(31,32)33)29(34,35)36/h2-6,8-9,17,19,24H,7,10-16H2,1H3/t24-,26-/m1/s1 LSGPKMNRHVPCGC-AOYPEHQESA-N 382282 US10273259, Example 50::US10711020, Example 50 Nuclear receptor ROR-gamma [262-507] 53.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382282 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382282&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678653 404851655 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 930964 Cc1ccc(cc1)S(=O)(=O)C12CCN(C1COc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)[C@H]1CC[C@@H](CC1)C(O)=O InChI=1S/C29H28F7NO6S/c1-16-2-9-20(10-3-16)44(41,42)26-12-13-37(24(38)17-4-6-18(7-5-17)25(39)40)23(26)15-43-22-14-19(8-11-21(22)26)27(30,28(31,32)33)29(34,35)36/h2-3,8-11,14,17-18,23H,4-7,12-13,15H2,1H3,(H,39,40)/t17-,18-,23?,26? DCHVBHWKUXXLNW-GIHSMNABSA-N 382285 US10273259, Example 51::US10711020, Example 51 Nuclear receptor ROR-gamma [262-507] 85.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382285 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382285&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678964 404851658 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 930965 CC(=O)C1CCC(CC1)C(=O)N1CCC2(C1COc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(C)cc1 InChI=1S/C30H30F7NO5S/c1-17-3-10-22(11-4-17)44(41,42)27-13-14-38(26(40)20-7-5-19(6-8-20)18(2)39)25(27)16-43-24-15-21(9-12-23(24)27)28(31,29(32,33)34)30(35,36)37/h3-4,9-12,15,19-20,25H,5-8,13-14,16H2,1-2H3 NBLQABCGWBYYHL-UHFFFAOYSA-N 453090 US10711020, Example 52 Nuclear receptor ROR-gamma [262-507] 73.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=453090 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=453090&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 139387082 440969057 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 930966 Cc1ccc(cc1)S(=O)(=O)C12CCN(C1COc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1CCS(=O)(=O)CC1 InChI=1S/C27H26F7NO6S2/c1-16-2-5-19(6-3-16)43(39,40)24-10-11-35(23(36)17-8-12-42(37,38)13-9-17)22(24)15-41-21-14-18(4-7-20(21)24)25(28,26(29,30)31)27(32,33)34/h2-7,14,17,22H,8-13,15H2,1H3 RWYKCRQSSRVCFK-UHFFFAOYSA-N 382287 US10273259, Example 53::US10711020, Example 53 Nuclear receptor ROR-gamma [262-507] 121 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382287 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382287&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678570 404851660 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 930967 CC(=O)C12CCC(CC1)(CC2)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccccc1 InChI=1S/C32H32F7NO4S/c1-20(41)27-11-14-28(15-12-27,16-13-27)26(42)40-18-17-29(45(43,44)23-5-3-2-4-6-23)24-9-8-22(19-21(24)7-10-25(29)40)30(33,31(34,35)36)32(37,38)39/h2-6,8-9,19,25H,7,10-18H2,1H3/t25-,27?,28?,29-/m1/s1 PDSBNXJZQZNVJF-RFBOAJLRSA-N 453092 US10711020, Example 54 Nuclear receptor ROR-gamma [262-507] 60.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=453092 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=453092&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 139387083 440969059 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 930968 FC(F)(F)C(F)(c1ccc2c(CC[C@H]3N(CC[C@@]23S(=O)(=O)c2ccccc2)C(=O)C2CCS(=O)(=O)CC2)c1)C(F)(F)F InChI=1S/C27H26F7NO5S2/c28-25(26(29,30)31,27(32,33)34)19-7-8-21-18(16-19)6-9-22-24(21,42(39,40)20-4-2-1-3-5-20)12-13-35(22)23(36)17-10-14-41(37,38)15-11-17/h1-5,7-8,16-17,22H,6,9-15H2/t22-,24-/m1/s1 QFANYMMGAGSSKB-ISKFKSNPSA-N 382290 US10273259, Example 55::US10711020, Example 55 Nuclear receptor ROR-gamma [262-507] 60.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382290 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382290&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678573 404851663 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 930969 OC(=O)[C@H]1CC[C@@](O)(CC1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccccc1 InChI=1S/C29H28F7NO6S/c30-27(28(31,32)33,29(34,35)36)19-7-8-21-18(16-19)6-9-22-26(21,44(42,43)20-4-2-1-3-5-20)14-15-37(22)24(40)25(41)12-10-17(11-13-25)23(38)39/h1-5,7-8,16-17,22,41H,6,9-15H2,(H,38,39)/t17-,22-,25+,26-/m1/s1 WSLUKAWNPCTYDQ-FQQZQYMPSA-N 382293 US10273259, Example 56::US10711020, Example 79 Nuclear receptor ROR-gamma [262-507] 183 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382293 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382293&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678855 404851666 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 930970 C[C@@]1(CC[C@@H](CC1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccccc1)C(O)=O InChI=1S/C30H30F7NO5S/c1-26(25(40)41)13-11-18(12-14-26)24(39)38-16-15-27(44(42,43)21-5-3-2-4-6-21)22-9-8-20(17-19(22)7-10-23(27)38)28(31,29(32,33)34)30(35,36)37/h2-6,8-9,17-18,23H,7,10-16H2,1H3,(H,40,41)/t18-,23-,26-,27-/m1/s1 JCWKZEXJYWCBFY-SRWMLJHBSA-N 382298 US10273259, Example 57::US10711020, Example 57 Nuclear receptor ROR-gamma [262-507] 49.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382298 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382298&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678575 404851671 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 930971 C[C@@]1(CC[C@@H](CC1)C(O)=O)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccccc1 InChI=1S/C30H30F7NO5S/c1-26(13-11-18(12-14-26)24(39)40)25(41)38-16-15-27(44(42,43)21-5-3-2-4-6-21)22-9-8-20(17-19(22)7-10-23(27)38)28(31,29(32,33)34)30(35,36)37/h2-6,8-9,17-18,23H,7,10-16H2,1H3,(H,39,40)/t18-,23-,26-,27-/m1/s1 MVXCZYDDJZYFRS-SRWMLJHBSA-N 382311 US10273259, Example 58::US10711020, Example 58 Nuclear receptor ROR-gamma [262-507] 85.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382311 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382311&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678851 404851684 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 930972 Cc1ccc(cc1)S(=O)(=O)C12CCN(C1COc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C12CCC(CC1)(CC2)C(O)=O InChI=1S/C31H30F7NO6S/c1-18-2-5-20(6-3-18)46(43,44)28-14-15-39(24(40)26-8-11-27(12-9-26,13-10-26)25(41)42)23(28)17-45-22-16-19(4-7-21(22)28)29(32,30(33,34)35)31(36,37)38/h2-7,16,23H,8-15,17H2,1H3,(H,41,42) HUEROKBEJHSLGM-UHFFFAOYSA-N 382326 US10273259, Example 59::US10711020, Example 59 Nuclear receptor ROR-gamma [262-507] 103 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382326 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382326&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678990 404851698 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 930973 Cc1ccc(cc1)S(=O)(=O)C12CCN(C1COc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)[C@@]1(C)CC[C@@H](CC1)C(O)=O InChI=1S/C30H30F7NO6S/c1-17-3-6-20(7-4-17)45(42,43)27-13-14-38(25(41)26(2)11-9-18(10-12-26)24(39)40)23(27)16-44-22-15-19(5-8-21(22)27)28(31,29(32,33)34)30(35,36)37/h3-8,15,18,23H,9-14,16H2,1-2H3,(H,39,40)/t18-,23?,26-,27? DZOCEMKCRHLMQC-OTZBKSJOSA-N 382327 US10273259, Example 60::US10711020, Example 60 Nuclear receptor ROR-gamma [262-507] 71.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382327 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382327&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678585 404851699 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 930974 Cc1ccc(cc1)S(=O)(=O)C12CCN(C1COc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)[C@@]1(O)CC[C@@H](CC1)C(O)=O InChI=1S/C29H28F7NO7S/c1-16-2-5-19(6-3-16)45(42,43)26-12-13-37(24(40)25(41)10-8-17(9-11-25)23(38)39)22(26)15-44-21-14-18(4-7-20(21)26)27(30,28(31,32)33)29(34,35)36/h2-7,14,17,22,41H,8-13,15H2,1H3,(H,38,39)/t17-,22?,25+,26? GPUPCDORHIMSOQ-ZZDDDDRDSA-N 382340 US10273259, Example 61::US10711020, Example 61 Nuclear receptor ROR-gamma [262-507] 454 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382340 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382340&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678992 404851712 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 930975 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(F)C(F)(F)F)S(=O)(=O)c1ccc(Cl)cc1 InChI=1S/C28H27ClF5NO5S/c29-21-7-9-22(10-8-21)41(39,40)27-13-14-35(25(36)18-2-4-19(5-3-18)26(37)38)24(27)12-6-20-15-17(1-11-23(20)27)16-34-28(30,31,32)33/h1,7-11,15,18-19,24H,2-6,12-14H2,(H,37,38)/t18-,19-,24?,27? DPLLLOBFDZHCFP-QXIWJBPRSA-N 453100 US10711020, Example 62 Nuclear receptor ROR-gamma [262-507] 33.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=453100 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=453100&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 132123468 440969067 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 930976 OC(=O)[C@H]1CC[C@@](O)(CC1)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(Cl)cc1 InChI=1S/C29H27ClF7NO6S/c30-19-3-5-20(6-4-19)45(43,44)26-13-14-38(24(41)25(42)11-9-16(10-12-25)23(39)40)22(26)8-1-17-15-18(2-7-21(17)26)27(31,28(32,33)34)29(35,36)37/h2-7,15-16,22,42H,1,8-14H2,(H,39,40)/t16-,22?,25+,26? TYAAJBCLFWLEPD-VXBFRIGJSA-N 382345 US10273259, Example 63::US10711020, Example 63 Nuclear receptor ROR-gamma [262-507] 21.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382345 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382345&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678774 404851717 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 930977 C[C@@]1(CC[C@@H](CC1)C(O)=O)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(Cl)cc1 InChI=1S/C30H29ClF7NO5S/c1-26(12-10-17(11-13-26)24(40)41)25(42)39-15-14-27(45(43,44)21-6-4-20(31)5-7-21)22-8-3-19(16-18(22)2-9-23(27)39)28(32,29(33,34)35)30(36,37)38/h3-8,16-17,23H,2,9-15H2,1H3,(H,40,41)/t17-,23?,26-,27? XBWBETBJTIWXIV-PYPIJRSMSA-N 382352 US10273259, Example 65::US10711020, Example 65 Nuclear receptor ROR-gamma [262-507] 58.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382352 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382352&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678988 404851724 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 930978 C[C@@]1(CC[C@@H](CC1)C(O)=O)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C30H29F8NO5S/c1-26(12-10-17(11-13-26)24(40)41)25(42)39-15-14-27(45(43,44)21-6-4-20(31)5-7-21)22-8-3-19(16-18(22)2-9-23(27)39)28(32,29(33,34)35)30(36,37)38/h3-8,16-17,23H,2,9-15H2,1H3,(H,40,41)/t17-,23-,26-,27-/m1/s1 IFTFEJQRBOPQKV-ZKPUSUNFSA-N 382353 US10273259, Example 66::US10711020, Example 66 Nuclear receptor ROR-gamma [262-507] 54.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382353 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382353&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122669103 404851725 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 930979 CC1(CCS(=O)(=O)CC1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H27F8NO5S2/c1-24(11-14-43(39,40)15-12-24)23(38)37-13-10-25(44(41,42)20-6-4-19(29)5-7-20)21-8-3-18(16-17(21)2-9-22(25)37)26(30,27(31,32)33)28(34,35)36/h3-8,16,22H,2,9-15H2,1H3/t22-,25-/m1/s1 CNZOURNMHUJTHK-RCZVLFRGSA-N 382354 US10273259, Example 67::US10711020, Example 67 Nuclear receptor ROR-gamma [262-507] 24.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382354 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382354&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678970 404851726 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 930980 C[C@@]1(CC[C@@H](CC1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1)C(O)=O InChI=1S/C30H29F8NO5S/c1-26(25(41)42)12-10-17(11-13-26)24(40)39-15-14-27(45(43,44)21-6-4-20(31)5-7-21)22-8-3-19(16-18(22)2-9-23(27)39)28(32,29(33,34)35)30(36,37)38/h3-8,16-17,23H,2,9-15H2,1H3,(H,41,42)/t17-,23-,26-,27-/m1/s1 RNUYUEWIROQCAN-ZKPUSUNFSA-N 382355 US10273259, Example 68::US10711020, Example 68 Nuclear receptor ROR-gamma [262-507] 23.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382355 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382355&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678779 404851727 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 930981 OC1(CCS(=O)(=O)CC1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C27H25F8NO6S2/c28-18-3-5-19(6-4-18)44(41,42)24-9-12-36(22(37)23(38)10-13-43(39,40)14-11-23)21(24)8-1-16-15-17(2-7-20(16)24)25(29,26(30,31)32)27(33,34)35/h2-7,15,21,38H,1,8-14H2/t21-,24-/m1/s1 ONXFNBOZJKXCNC-ZJSXRUAMSA-N 382356 US10273259, Example 69::US10711020, Example 69 Nuclear receptor ROR-gamma [262-507] 36.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382356 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382356&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122669265 404851728 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 930982 OC(=O)[C@H]1CC[C@@](O)(CC1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C29H27F8NO6S/c30-19-3-5-20(6-4-19)45(43,44)26-13-14-38(24(41)25(42)11-9-16(10-12-25)23(39)40)22(26)8-1-17-15-18(2-7-21(17)26)27(31,28(32,33)34)29(35,36)37/h2-7,15-16,22,42H,1,8-14H2,(H,39,40)/t16-,22-,25+,26-/m1/s1 NIKFOKKZAYXJKS-PNOGGZOTSA-N 382357 US10273259, Example 70::US10711020, Example 70 Nuclear receptor ROR-gamma [262-507] 68.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382357 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382357&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678576 404851729 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 930983 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H27F6NO5S/c29-20-7-9-21(10-8-20)41(39,40)26-13-14-35(24(36)16-1-3-17(4-2-16)25(37)38)23(26)12-5-18-15-19(6-11-22(18)26)27(30,31)28(32,33)34/h6-11,15-17,23H,1-5,12-14H2,(H,37,38)/t16-,17-,23?,26? ZSEJTFSGSGDQLS-LRVXPCDCSA-N 453108 US10711020, Example 71 Nuclear receptor ROR-gamma [262-507] 31.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=453108 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=453108&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 132123610 440969075 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 930984 CC(F)(F)C(F)(F)c1ccc2c(CCC3N(CCC23S(=O)(=O)c2ccc(F)cc2)C(=O)C23CCC(CC2)(CC3)C(O)=O)c1 InChI=1S/C31H32F5NO5S/c1-27(33,34)31(35,36)20-3-8-23-19(18-20)2-9-24-30(23,43(41,42)22-6-4-21(32)5-7-22)16-17-37(24)25(38)28-10-13-29(14-11-28,15-12-28)26(39)40/h3-8,18,24H,2,9-17H2,1H3,(H,39,40) ITBGOZPNTUCEKB-UHFFFAOYSA-N 453109 US10711020, Example 72 Nuclear receptor ROR-gamma [262-507] 28.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=453109 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=453109&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 155883574 440969076 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 930985 Cc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)[C@@]1(O)CC[C@@H](CC1)C(O)=O InChI=1S/C30H30F7NO6S/c1-17-2-6-21(7-3-17)45(43,44)27-14-15-38(25(41)26(42)12-10-18(11-13-26)24(39)40)23(27)9-4-19-16-20(5-8-22(19)27)28(31,29(32,33)34)30(35,36)37/h2-3,5-8,16,18,23,42H,4,9-15H2,1H3,(H,39,40)/t18-,23-,26+,27-/m1/s1 HZUVIRMBMVZZEX-GSSVGNISSA-N 382360 US10273259, Example 73::US10711020, Example 73 Nuclear receptor ROR-gamma [262-507] 78.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382360 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382360&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678780 404851732 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 930986 OC(=O)C12CCC(CC1)(CC2)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C30H29F6NO5S/c31-20-3-5-21(6-4-20)43(41,42)28-15-16-37(24(38)26-9-12-27(13-10-26,14-11-26)25(39)40)23(28)8-1-18-17-19(2-7-22(18)28)29(32,33)30(34,35)36/h2-7,17,23H,1,8-16H2,(H,39,40) WUTQPYOBYMGHLC-UHFFFAOYSA-N 382359 US10273259, Example 72::US10711020, Example 74 Nuclear receptor ROR-gamma [262-507] 18.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382359 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382359&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 132123756 404851731 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 930987 OC1(CCS(=O)(=O)CC1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccccc1 InChI=1S/C27H26F7NO6S2/c28-25(26(29,30)31,27(32,33)34)18-7-8-20-17(16-18)6-9-21-24(20,43(40,41)19-4-2-1-3-5-19)10-13-35(21)22(36)23(37)11-14-42(38,39)15-12-23/h1-5,7-8,16,21,37H,6,9-15H2/t21-,24-/m1/s1 RCFBNKKNTAABCX-ZJSXRUAMSA-N 382362 US10273259, Example 75::US10711020, Example 75 Nuclear receptor ROR-gamma [262-507] 43.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382362 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382362&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678574 404851734 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 930988 CC1(CCS(=O)(=O)CC1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccccc1 InChI=1S/C28H28F7NO5S2/c1-24(12-15-42(38,39)16-13-24)23(37)36-14-11-25(43(40,41)20-5-3-2-4-6-20)21-9-8-19(17-18(21)7-10-22(25)36)26(29,27(30,31)32)28(33,34)35/h2-6,8-9,17,22H,7,10-16H2,1H3/t22-,25-/m1/s1 KRPYRQCNVXRDGI-RCZVLFRGSA-N 382363 US10273259, Example 76::US10711020, Example 76 Nuclear receptor ROR-gamma [262-507] 45.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382363 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382363&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678582 404851735 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 930989 OC(=O)[C@H]1CC[C@@](F)(CC1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccccc1 InChI=1S/C29H27F8NO5S/c30-25(12-10-17(11-13-25)23(39)40)24(41)38-15-14-26(44(42,43)20-4-2-1-3-5-20)21-8-7-19(16-18(21)6-9-22(26)38)27(31,28(32,33)34)29(35,36)37/h1-5,7-8,16-17,22H,6,9-15H2,(H,39,40)/t17-,22-,25+,26-/m1/s1 YYNXLIDUFMGKIU-FQQZQYMPSA-N 382364 US10273259, Example 77::US10711020, Example 77 Nuclear receptor ROR-gamma [262-507] 33.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382364 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382364&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678860 404851736 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 930990 OC(=O)[C@@]1(F)CC[C@@H](CC1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccccc1 InChI=1S/C29H27F8NO5S/c30-25(24(40)41)12-10-17(11-13-25)23(39)38-15-14-26(44(42,43)20-4-2-1-3-5-20)21-8-7-19(16-18(21)6-9-22(26)38)27(31,28(32,33)34)29(35,36)37/h1-5,7-8,16-17,22H,6,9-15H2,(H,40,41)/t17-,22-,25+,26-/m1/s1 VQRUKJALSUNAQR-FQQZQYMPSA-N 382365 US10273259, Example 78::US10711020, Example 78 Nuclear receptor ROR-gamma [262-507] 42.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382365 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382365&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678986 404851737 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 930991 OC(=O)[C@H]1CC[C@@](O)(CC1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccccc1 InChI=1S/C29H28F7NO6S/c30-27(28(31,32)33,29(34,35)36)19-7-8-21-18(16-19)6-9-22-26(21,44(42,43)20-4-2-1-3-5-20)14-15-37(22)24(40)25(41)12-10-17(11-13-25)23(38)39/h1-5,7-8,16-17,22,41H,6,9-15H2,(H,38,39)/t17-,22-,25+,26-/m1/s1 WSLUKAWNPCTYDQ-FQQZQYMPSA-N 382293 US10273259, Example 56::US10711020, Example 79 Nuclear receptor ROR-gamma [262-507] 33.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382293 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382293&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678855 404851666 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 930992 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H27F6NO5S/c29-20-7-9-21(10-8-20)41(39,40)26-13-14-35(24(36)16-1-3-17(4-2-16)25(37)38)23(26)12-5-18-15-19(6-11-22(18)26)27(30,31)28(32,33)34/h6-11,15-17,23H,1-5,12-14H2,(H,37,38)/t16-,17-,23?,26? ZSEJTFSGSGDQLS-LRVXPCDCSA-N 453117 US10711020, Example 80 Nuclear receptor ROR-gamma [262-507] 19.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=453117 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=453117&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 132123610 440969083 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 930993 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CCC2(C1COc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccccc1 InChI=1S/C28H26F7NO6S/c29-26(27(30,31)32,28(33,34)35)18-10-11-20-21(14-18)42-15-22-25(20,43(40,41)19-4-2-1-3-5-19)12-13-36(22)23(37)16-6-8-17(9-7-16)24(38)39/h1-5,10-11,14,16-17,22H,6-9,12-13,15H2,(H,38,39)/t16-,17-,22?,25? INPQVNKLKDYELZ-FECXEKGZSA-N 382368 US10273259, Example 81::US10711020, Example 81 Nuclear receptor ROR-gamma [262-507] 46.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382368 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382368&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678783 404851740 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 930994 FC(F)(F)C(F)(c1ccc2c(OCC3N(CCC23S(=O)(=O)c2ccccc2)C(=O)C2CCS(=O)(=O)CC2)c1)C(F)(F)F InChI=1S/C26H24F7NO6S2/c27-24(25(28,29)30,26(31,32)33)17-6-7-19-20(14-17)40-15-21-23(19,42(38,39)18-4-2-1-3-5-18)10-11-34(21)22(35)16-8-12-41(36,37)13-9-16/h1-7,14,16,21H,8-13,15H2 HZXMXVQPZQPLMM-UHFFFAOYSA-N 382369 US10273259, Example 82::US10711020, Example 82 Nuclear receptor ROR-gamma [262-507] 67.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382369 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382369&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678858 404851741 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 930995 C[C@@]1(CC[C@@H](CC1)C(=O)N1CCC2(C1COc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccccc1)C(O)=O InChI=1S/C29H28F7NO6S/c1-25(24(39)40)11-9-17(10-12-25)23(38)37-14-13-26(44(41,42)19-5-3-2-4-6-19)20-8-7-18(15-21(20)43-16-22(26)37)27(30,28(31,32)33)29(34,35)36/h2-8,15,17,22H,9-14,16H2,1H3,(H,39,40)/t17-,22?,25-,26? UGGQWQNGBFUCAT-VWGAXAFBSA-N 382370 US10273259, Example 83::US10711020, Example 83 Nuclear receptor ROR-gamma [262-507] 39.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382370 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382370&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678578 404851742 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 930996 OC(=O)[C@H]1CC[C@@](F)(CC1)C(=O)N1CCC2(C1COc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccccc1 InChI=1S/C28H25F8NO6S/c29-24(10-8-16(9-11-24)22(38)39)23(40)37-13-12-25(44(41,42)18-4-2-1-3-5-18)19-7-6-17(14-20(19)43-15-21(25)37)26(30,27(31,32)33)28(34,35)36/h1-7,14,16,21H,8-13,15H2,(H,38,39)/t16-,21?,24+,25? VXOOZMHBUVWMTC-QNINJKENSA-N 382372 US10273259, Example 84::US10711020, Example 84 Nuclear receptor ROR-gamma [262-507] 33.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382372 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382372&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678787 404851744 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 930997 CC1(CCS(=O)(=O)CC1)C(=O)N1CCC2(C1COc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccccc1 InChI=1S/C27H26F7NO6S2/c1-23(10-13-42(37,38)14-11-23)22(36)35-12-9-24(43(39,40)18-5-3-2-4-6-18)19-8-7-17(15-20(19)41-16-21(24)35)25(28,26(29,30)31)27(32,33)34/h2-8,15,21H,9-14,16H2,1H3 ZQRMMOBPNILDIZ-UHFFFAOYSA-N 382373 US10273259, Example 85::US10711020, Example 85 Nuclear receptor ROR-gamma [262-507] 16.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382373 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382373&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678997 404851745 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 930998 C[C@@]1(CC[C@@H](CC1)C(O)=O)C(=O)N1CCC2(C1COc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccccc1 InChI=1S/C29H28F7NO6S/c1-25(11-9-17(10-12-25)23(38)39)24(40)37-14-13-26(44(41,42)19-5-3-2-4-6-19)20-8-7-18(15-21(20)43-16-22(26)37)27(30,28(31,32)33)29(34,35)36/h2-8,15,17,22H,9-14,16H2,1H3,(H,38,39)/t17-,22?,25-,26? IKWYTHJBHVJSDY-VWGAXAFBSA-N 382374 US10273259, Example 86::US10711020, Example 86 Nuclear receptor ROR-gamma [262-507] 41.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382374 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382374&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678857 404851746 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 930999 OC(=O)[C@@]1(F)CC[C@@H](CC1)C(=O)N1CCC2(C1COc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccccc1 InChI=1S/C28H25F8NO6S/c29-24(23(39)40)10-8-16(9-11-24)22(38)37-13-12-25(44(41,42)18-4-2-1-3-5-18)19-7-6-17(14-20(19)43-15-21(25)37)26(30,27(31,32)33)28(34,35)36/h1-7,14,16,21H,8-13,15H2,(H,39,40)/t16-,21?,24+,25? AHDDXJIGAVOHPK-QNINJKENSA-N 382375 US10273259, Example 87::US10711020, Example 87 Nuclear receptor ROR-gamma [262-507] 39.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382375 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382375&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678865 404851747 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931000 OC(=O)C12CCC(CC1)(CC2)C(=O)N1CCC2(C1COc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccccc1 InChI=1S/C30H28F7NO6S/c31-28(29(32,33)34,30(35,36)37)18-6-7-20-21(16-18)44-17-22-27(20,45(42,43)19-4-2-1-3-5-19)14-15-38(22)23(39)25-8-11-26(12-9-25,13-10-25)24(40)41/h1-7,16,22H,8-15,17H2,(H,40,41) INMOJOTXZUOHSX-UHFFFAOYSA-N 382376 US10273259, Example 88::US10711020, Example 88 Nuclear receptor ROR-gamma [262-507] 56.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382376 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382376&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678870 404851748 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931001 OC1(CCS(=O)(=O)CC1)C(=O)N1CCC2(C1COc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccccc1 InChI=1S/C26H24F7NO7S2/c27-24(25(28,29)30,26(31,32)33)16-6-7-18-19(14-16)41-15-20-23(18,43(39,40)17-4-2-1-3-5-17)8-11-34(20)21(35)22(36)9-12-42(37,38)13-10-22/h1-7,14,20,36H,8-13,15H2 IQHNBPNFOBFJAZ-UHFFFAOYSA-N 382377 US10273259, Example 89::US10711020, Example 89 Nuclear receptor ROR-gamma [262-507] 79.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382377 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382377&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678878 404851749 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931002 Cc1ccc(cc1)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1(O)CCS(=O)(=O)CC1 InChI=1S/C28H28F7NO6S2/c1-17-2-6-20(7-3-17)44(41,42)25-10-13-36(23(37)24(38)11-14-43(39,40)15-12-24)22(25)9-4-18-16-19(5-8-21(18)25)26(29,27(30,31)32)28(33,34)35/h2-3,5-8,16,22,38H,4,9-15H2,1H3 CNFDTDNDGRHKHU-UHFFFAOYSA-N 382378 US10273259, Example 90::US10711020, Example 90 Nuclear receptor ROR-gamma [262-507] 76.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382378 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382378&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678657 404851750 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931003 Cc1ccc(cc1)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1(C)CCS(=O)(=O)CC1 InChI=1S/C29H30F7NO5S2/c1-18-3-7-21(8-4-18)44(41,42)26-11-14-37(24(38)25(2)12-15-43(39,40)16-13-25)23(26)10-5-19-17-20(6-9-22(19)26)27(30,28(31,32)33)29(34,35)36/h3-4,6-9,17,23H,5,10-16H2,1-2H3 HEZBHCDVHMWMHJ-UHFFFAOYSA-N 382379 US10273259, Example 91::US10711020, Example 91 Nuclear receptor ROR-gamma [262-507] 28.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382379 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382379&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678579 404851751 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931004 CN1[C@@H](CCC1=O)C(=O)N1CCC2(C1COc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccccc1 InChI=1S/C26H23F7N2O5S/c1-34-18(9-10-21(34)36)22(37)35-12-11-23(41(38,39)16-5-3-2-4-6-16)17-8-7-15(13-19(17)40-14-20(23)35)24(27,25(28,29)30)26(31,32)33/h2-8,13,18,20H,9-12,14H2,1H3/t18-,20?,23?/m0/s1 XFAGESYDLJMEQC-QRGRWYIGSA-N 382380 US10273259, Example 92::US10273259, Example 94::US10711020, Example 94 Nuclear receptor ROR-gamma [262-507] 62.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382380 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382380&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678991 404851752 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931005 CN1[C@@H](CCC1=O)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccccc1 InChI=1S/C27H25F7N2O4S/c1-35-20(10-12-22(35)37)23(38)36-14-13-24(41(39,40)18-5-3-2-4-6-18)19-9-8-17(15-16(19)7-11-21(24)36)25(28,26(29,30)31)27(32,33)34/h2-6,8-9,15,20-21H,7,10-14H2,1H3/t20-,21+,24+/m0/s1 PONKZASPLBAOKT-YZUZCNPQSA-N 382381 US10273259, Example 93::US10273259, Example 95::US10711020, Example 95 Nuclear receptor ROR-gamma [262-507] 71.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382381 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382381&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678879 404851753 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931006 CN1[C@@H](CCC1=O)C(=O)N1CCC2(C1COc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccccc1 InChI=1S/C26H23F7N2O5S/c1-34-18(9-10-21(34)36)22(37)35-12-11-23(41(38,39)16-5-3-2-4-6-16)17-8-7-15(13-19(17)40-14-20(23)35)24(27,25(28,29)30)26(31,32)33/h2-8,13,18,20H,9-12,14H2,1H3/t18-,20?,23?/m0/s1 XFAGESYDLJMEQC-QRGRWYIGSA-N 382380 US10273259, Example 92::US10273259, Example 94::US10711020, Example 94 Nuclear receptor ROR-gamma [262-507] 20.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382380 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382380&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678991 404851752 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931007 CN1[C@@H](CCC1=O)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccccc1 InChI=1S/C27H25F7N2O4S/c1-35-20(10-12-22(35)37)23(38)36-14-13-24(41(39,40)18-5-3-2-4-6-18)19-9-8-17(15-16(19)7-11-21(24)36)25(28,26(29,30)31)27(32,33)34/h2-6,8-9,15,20-21H,7,10-14H2,1H3/t20-,21+,24+/m0/s1 PONKZASPLBAOKT-YZUZCNPQSA-N 382381 US10273259, Example 93::US10273259, Example 95::US10711020, Example 95 Nuclear receptor ROR-gamma [262-507] 50.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382381 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382381&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678879 404851753 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931008 Cc1ccc(cc1Cl)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1CCS(=O)(=O)CC1 InChI=1S/C28H27ClF7NO5S2/c1-16-2-5-20(15-22(16)29)44(41,42)25-10-11-37(24(38)17-8-12-43(39,40)13-9-17)23(25)7-3-18-14-19(4-6-21(18)25)26(30,27(31,32)33)28(34,35)36/h2,4-6,14-15,17,23H,3,7-13H2,1H3 TYROYDROEXPYSI-UHFFFAOYSA-N 382384 US10273259, Example 96::US10711020, Example 96 Nuclear receptor ROR-gamma [262-507] 118 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382384 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382384&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678583 404851754 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931744 C[C@H]1CC(C)(O)CC[C@H]1C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1cccc(F)c1 InChI=1S/C30H31F8NO4S/c1-17-16-26(2,41)11-10-22(17)25(40)39-13-12-27(44(42,43)21-5-3-4-20(31)15-21)23-8-7-19(14-18(23)6-9-24(27)39)28(32,29(33,34)35)30(36,37)38/h3-5,7-8,14-15,17,22,24,41H,6,9-13,16H2,1-2H3/t17-,22+,24?,26?,27?/m0/s1 JOORRAWMWPLQPV-VVAIGMAFSA-N 383123 (9b-((3-fluorophenyl)sulfonyl)-7-(perfluoropropan-2-yl)-1,2,3a,4,5,9b-hexahydro-3H-benzo[e]indol-3-yl)((1R,2S)-4-hydroxy-2,4-dimethylcyclohexyl)methanone (2 Single Diastereomers)::US10273259, Example 834::US10273259, Example 835::US10711020, Example 835 Nuclear receptor ROR-gamma [262-507] 172 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383123 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383123&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122669089 404852425 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931745 C[C@H]1CC(C)(O)CC[C@H]1C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1cccc(F)c1 InChI=1S/C30H31F8NO4S/c1-17-16-26(2,41)11-10-22(17)25(40)39-13-12-27(44(42,43)21-5-3-4-20(31)15-21)23-8-7-19(14-18(23)6-9-24(27)39)28(32,29(33,34)35)30(36,37)38/h3-5,7-8,14-15,17,22,24,41H,6,9-13,16H2,1-2H3/t17-,22+,24?,26?,27?/m0/s1 JOORRAWMWPLQPV-VVAIGMAFSA-N 383123 (9b-((3-fluorophenyl)sulfonyl)-7-(perfluoropropan-2-yl)-1,2,3a,4,5,9b-hexahydro-3H-benzo[e]indol-3-yl)((1R,2S)-4-hydroxy-2,4-dimethylcyclohexyl)methanone (2 Single Diastereomers)::US10273259, Example 834::US10273259, Example 835::US10711020, Example 835 Nuclear receptor ROR-gamma [262-507] 83.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383123 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383123&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122669089 404852425 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931746 C[C@H]1CC(CC[C@H]1C(O)=O)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1cccc(F)c1 InChI=1S/C30H29F8NO5S/c1-16-13-18(5-8-22(16)26(41)42)25(40)39-12-11-27(45(43,44)21-4-2-3-20(31)15-21)23-9-7-19(14-17(23)6-10-24(27)39)28(32,29(33,34)35)30(36,37)38/h2-4,7,9,14-16,18,22,24H,5-6,8,10-13H2,1H3,(H,41,42)/t16-,18?,22+,24?,27?/m0/s1 VSNITFSVOGKQJM-PEZFPZIYSA-N 383125 (1R,2S)-4-(9b-((3-fluorophenyl)sulfonyl)-7-(perfluoropropan-2-yl)-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]indole-3-carbonyl)-2-methylcyclohexane-1-carboxylic acid (2 Single Diastereomers)::US10273259, Example 836::US10273259, Example 837::US10711020, Example 837 Nuclear receptor ROR-gamma [262-507] 13.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383125 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383125&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122669165 404852426 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931747 C[C@H]1CC(CC[C@H]1C(O)=O)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1cccc(F)c1 InChI=1S/C30H29F8NO5S/c1-16-13-18(5-8-22(16)26(41)42)25(40)39-12-11-27(45(43,44)21-4-2-3-20(31)15-21)23-9-7-19(14-17(23)6-10-24(27)39)28(32,29(33,34)35)30(36,37)38/h2-4,7,9,14-16,18,22,24H,5-6,8,10-13H2,1H3,(H,41,42)/t16-,18?,22+,24?,27?/m0/s1 VSNITFSVOGKQJM-PEZFPZIYSA-N 383125 (1R,2S)-4-(9b-((3-fluorophenyl)sulfonyl)-7-(perfluoropropan-2-yl)-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]indole-3-carbonyl)-2-methylcyclohexane-1-carboxylic acid (2 Single Diastereomers)::US10273259, Example 836::US10273259, Example 837::US10711020, Example 837 Nuclear receptor ROR-gamma [262-507] 56.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383125 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383125&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122669165 404852426 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931748 C[C@H]1CC(CC[C@H]1C(O)=O)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C30H29F8NO5S/c1-16-14-18(2-9-22(16)26(41)42)25(40)39-13-12-27(45(43,44)21-7-5-20(31)6-8-21)23-10-4-19(15-17(23)3-11-24(27)39)28(32,29(33,34)35)30(36,37)38/h4-8,10,15-16,18,22,24H,2-3,9,11-14H2,1H3,(H,41,42)/t16-,18?,22+,24+,27+/m0/s1 RVOCLWFWWBLIOH-UFHIEMDVSA-N 383127 (1R,2S)-4-((3aR,9bR)-9b-((4-fluorophenyl)sulfonyl)-7-(perfluoropropan-2-yl)-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]indole-3-carbonyl)-2-methylcyclohexane-1-carboxylic acid (2 Single Diastereomers)::US10273259, Example 838::US10273259, Example 839::US10273259, Example 840::US10273259, Example 841::US10711020, Example 839 Nuclear receptor ROR-gamma [262-507] 75.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383127 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383127&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122669203 404852427 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931749 C[C@H]1CC(CC[C@H]1C(O)=O)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C30H29F8NO5S/c1-16-14-18(2-9-22(16)26(41)42)25(40)39-13-12-27(45(43,44)21-7-5-20(31)6-8-21)23-10-4-19(15-17(23)3-11-24(27)39)28(32,29(33,34)35)30(36,37)38/h4-8,10,15-16,18,22,24H,2-3,9,11-14H2,1H3,(H,41,42)/t16-,18?,22+,24+,27+/m0/s1 RVOCLWFWWBLIOH-UFHIEMDVSA-N 383127 (1R,2S)-4-((3aR,9bR)-9b-((4-fluorophenyl)sulfonyl)-7-(perfluoropropan-2-yl)-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]indole-3-carbonyl)-2-methylcyclohexane-1-carboxylic acid (2 Single Diastereomers)::US10273259, Example 838::US10273259, Example 839::US10273259, Example 840::US10273259, Example 841::US10711020, Example 839 Nuclear receptor ROR-gamma [262-507] 416 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383127 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383127&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122669203 404852427 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931750 C[C@@H]1CC(CC[C@H]1C(O)=O)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C30H29F8NO5S/c1-16-14-18(2-9-22(16)26(41)42)25(40)39-13-12-27(45(43,44)21-7-5-20(31)6-8-21)23-10-4-19(15-17(23)3-11-24(27)39)28(32,29(33,34)35)30(36,37)38/h4-8,10,15-16,18,22,24H,2-3,9,11-14H2,1H3,(H,41,42)/t16-,18?,22-,24-,27-/m1/s1 RVOCLWFWWBLIOH-FXRNFHIUSA-N 453875 (1R,2R)-4-((3aR,9bR)-9b-((4-fluorophenyl)sulfonyl)-7-(perfluoropropan-2-yl)-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]indole-3-carbonyl)-2-methylcyclohexane-1-carboxylic Acid (2 Single Diastereomers)::US10711020, Example 840::US10711020, Example 841 Nuclear receptor ROR-gamma [262-507] 82.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=453875 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=453875&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122669130 440969759 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931751 C[C@@H]1CC(CC[C@H]1C(O)=O)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C30H29F8NO5S/c1-16-14-18(2-9-22(16)26(41)42)25(40)39-13-12-27(45(43,44)21-7-5-20(31)6-8-21)23-10-4-19(15-17(23)3-11-24(27)39)28(32,29(33,34)35)30(36,37)38/h4-8,10,15-16,18,22,24H,2-3,9,11-14H2,1H3,(H,41,42)/t16-,18?,22-,24-,27-/m1/s1 RVOCLWFWWBLIOH-FXRNFHIUSA-N 453875 (1R,2R)-4-((3aR,9bR)-9b-((4-fluorophenyl)sulfonyl)-7-(perfluoropropan-2-yl)-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]indole-3-carbonyl)-2-methylcyclohexane-1-carboxylic Acid (2 Single Diastereomers)::US10711020, Example 840::US10711020, Example 841 Nuclear receptor ROR-gamma [262-507] 215 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=453875 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=453875&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122669130 440969759 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931752 C[C@@H]1CC(CC[C@H]1C(O)=O)C(=O)N1CCC2(C1COc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C29H27F8NO6S/c1-15-12-16(2-8-20(15)25(40)41)24(39)38-11-10-26(45(42,43)19-6-4-18(30)5-7-19)21-9-3-17(13-22(21)44-14-23(26)38)27(31,28(32,33)34)29(35,36)37/h3-7,9,13,15-16,20,23H,2,8,10-12,14H2,1H3,(H,40,41)/t15-,16?,20-,23?,26?/m1/s1 SVXGUOLWCJKEHB-SLSVQMFKSA-N 383131 (1R,2R)-4-(9b-((4-fluorophenyl)sulfonyl)-7-(perfluoropropan-2-yl)-1,2,3,3a,4,9b-hexahydrochromeno[3,4-b]pyrrole-3-carbonyl)-2-methylcyclohexane-1-carboxylic acid (2 Single Diastereomers)::US10273259, Example 842::US10273259, Example 843::US10711020, Example 843 Nuclear receptor ROR-gamma [262-507] 53.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383131 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383131&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122669272 404852428 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931753 C[C@@H]1CC(CC[C@H]1C(O)=O)C(=O)N1CCC2(C1COc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C29H27F8NO6S/c1-15-12-16(2-8-20(15)25(40)41)24(39)38-11-10-26(45(42,43)19-6-4-18(30)5-7-19)21-9-3-17(13-22(21)44-14-23(26)38)27(31,28(32,33)34)29(35,36)37/h3-7,9,13,15-16,20,23H,2,8,10-12,14H2,1H3,(H,40,41)/t15-,16?,20-,23?,26?/m1/s1 SVXGUOLWCJKEHB-SLSVQMFKSA-N 383131 (1R,2R)-4-(9b-((4-fluorophenyl)sulfonyl)-7-(perfluoropropan-2-yl)-1,2,3,3a,4,9b-hexahydrochromeno[3,4-b]pyrrole-3-carbonyl)-2-methylcyclohexane-1-carboxylic acid (2 Single Diastereomers)::US10273259, Example 842::US10273259, Example 843::US10711020, Example 843 Nuclear receptor ROR-gamma [262-507] 92.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383131 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383131&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122669272 404852428 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931754 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(c(Cl)cc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C29H26ClF8NO5S/c30-22-14-20-17(13-21(22)27(32,28(33,34)35)29(36,37)38)5-10-23-26(20,45(43,44)19-8-6-18(31)7-9-19)11-12-39(23)24(40)15-1-3-16(4-2-15)25(41)42/h6-9,13-16,23H,1-5,10-12H2,(H,41,42)/t15-,16-,23-,26-/m1/s1 NRSGHJVWWWPCST-DBJAZQRGSA-N 383133 (1R,4r)-4-((3aR,9bR)-8-chloro-9b-((4-fluorophenyl)sulfonyl)-7-(perfluoropropan-2-yl)-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]indole-3-carbonyl)cyclohexane-1-carboxylic acid::US10273259, Example 844::US10711020, Example 844 Nuclear receptor ROR-gamma [262-507] 97.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383133 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383133&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122669221 404852429 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931755 Cc1cc2c(CC[C@H]3N(CC[C@@]23S(=O)(=O)c2ccc(F)cc2)C(=O)[C@H]2CC[C@@H](CC2)C(O)=O)cc1C(F)(C(F)(F)F)C(F)(F)F InChI=1S/C30H29F8NO5S/c1-16-14-23-19(15-22(16)28(32,29(33,34)35)30(36,37)38)6-11-24-27(23,45(43,44)21-9-7-20(31)8-10-21)12-13-39(24)25(40)17-2-4-18(5-3-17)26(41)42/h7-10,14-15,17-18,24H,2-6,11-13H2,1H3,(H,41,42)/t17-,18-,24-,27-/m1/s1 ZFVKCNIIMDQMAG-BKNJMBQISA-N 383134 (1R,4r)-4-((3aR,9bR)-9b-((4-fluorophenyl)sulfonyl)-8-methyl-7-(perfluoropropan-2-yl)-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]indole-3-carbonyl)cyclohexane-1-carboxylic acid::US10273259, Example 845::US10711020, Example 845 Nuclear receptor ROR-gamma [262-507] 205 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383134 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383134&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122669054 404852430 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931756 Cc1cc2c(CC[C@H]3N(CC[C@@]23S(=O)(=O)c2ccc(F)cc2)C(=O)[C@H]2CC[C@@H](CC2)C(O)=O)c(C)c1C(F)(C(F)(F)F)C(F)(F)F InChI=1S/C31H31F8NO5S/c1-16-15-23-22(17(2)25(16)29(33,30(34,35)36)31(37,38)39)11-12-24-28(23,46(44,45)21-9-7-20(32)8-10-21)13-14-40(24)26(41)18-3-5-19(6-4-18)27(42)43/h7-10,15,18-19,24H,3-6,11-14H2,1-2H3,(H,42,43)/t18-,19-,24-,28-/m1/s1 HCMHBZWUIVDPJD-XARWWFPVSA-N 383135 (1R,4r)-4-((3aR,9bR)-9b-((4-fluorophenyl)sulfonyl)-6,8-dimethyl(d6)-7-(perfluoropropan-2-yl)-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]indole-3-carbonyl)cyclohexane-1-carboxylic acid::US10273259, Example 846::US10711020, Example 846 Nuclear receptor ROR-gamma [262-507] 57.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383135 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383135&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 145995617 404852431 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931757 COC(=O)C1(CCS(=O)(=O)CC1)NC(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C29H28F8N2O7S2/c1-46-23(40)25(11-14-47(42,43)15-12-25)38-24(41)39-13-10-26(48(44,45)20-6-4-19(30)5-7-20)21-8-3-18(16-17(21)2-9-22(26)39)27(31,28(32,33)34)29(35,36)37/h3-8,16,22H,2,9-15H2,1H3,(H,38,41)/t22-,26-/m1/s1 ZVHOSUKFUWRCTF-ATIYNZHBSA-N 383136 US10273259, Example 847::US10711020, Example 847 Nuclear receptor ROR-gamma [262-507] 99.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383136 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383136&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678953 404852432 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931758 FC(F)(F)C(F)(c1ccc2c(CC[C@@H]3N(CC[C@]23S(=O)(=O)c2ccccc2)C(=O)CN2CCS(=O)(=O)CC2)c1)C(F)(F)F InChI=1S/C27H27F7N2O5S2/c28-25(26(29,30)31,27(32,33)34)19-7-8-21-18(16-19)6-9-22-24(21,43(40,41)20-4-2-1-3-5-20)10-11-36(22)23(37)17-35-12-14-42(38,39)15-13-35/h1-5,7-8,16,22H,6,9-15,17H2/t22-,24-/m0/s1 DOMKFIOVSXNRFY-UPVQGACJSA-N 383137 US10273259, Example 848::US10711020, Example 848 Nuclear receptor ROR-gamma [262-507] 3306 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383137 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383137&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679208 404852433 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931759 CCN1CC2N(CCC2(c2ccc(cc12)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(Cl)cc1)C(=O)C1(O)CCS(=O)(=O)CC1 InChI=1S/C28H28ClF7N2O6S2/c1-2-37-16-22-25(46(43,44)19-6-4-18(29)5-7-19,9-12-38(22)23(39)24(40)10-13-45(41,42)14-11-24)20-8-3-17(15-21(20)37)26(30,27(31,32)33)28(34,35)36/h3-8,15,22,40H,2,9-14,16H2,1H3 OCYMAQYQLMOGHB-UHFFFAOYSA-N 383138 US10273259, Example 849::US10711020, Example 849 Nuclear receptor ROR-gamma [262-507] 616 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383138 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383138&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679200 404852434 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931760 FC(F)(F)C(F)(c1ccc2c(CC[C@H]3N(CC[C@@]23S(=O)(=O)c2ccccc2)C(=O)CN2CCS(=O)(=O)CC2)c1)C(F)(F)F InChI=1S/C27H27F7N2O5S2/c28-25(26(29,30)31,27(32,33)34)19-7-8-21-18(16-19)6-9-22-24(21,43(40,41)20-4-2-1-3-5-20)10-11-36(22)23(37)17-35-12-14-42(38,39)15-13-35/h1-5,7-8,16,22H,6,9-15,17H2/t22-,24-/m1/s1 DOMKFIOVSXNRFY-ISKFKSNPSA-N 383139 US10273259, Example 850::US10711020, Example 850 Nuclear receptor ROR-gamma [262-507] 274 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383139 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383139&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679300 404852435 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931761 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)c1ccc2nncn2c1 InChI=1S/C28H20F8N4O3S/c29-19-4-6-20(7-5-19)44(42,43)25-11-12-40(24(41)17-2-10-23-38-37-15-39(23)14-17)22(25)9-1-16-13-18(3-8-21(16)25)26(30,27(31,32)33)28(34,35)36/h2-8,10,13-15,22H,1,9,11-12H2/t22-,25-/m1/s1 HXWJDULVVNUERD-RCZVLFRGSA-N 383140 US10273259, Example 851::US10711020, Example 851 Nuclear receptor ROR-gamma [262-507] 357 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383140 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383140&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679204 404852436 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931762 FC(F)(F)C(F)(c1ccc2c(CCC3N(CCC23S(=O)(=O)c2ccc(Cl)cc2)C(=O)c2ccc3nncn3c2)c1)C(F)(F)F InChI=1S/C28H20ClF7N4O3S/c29-19-4-6-20(7-5-19)44(42,43)25-11-12-40(24(41)17-2-10-23-38-37-15-39(23)14-17)22(25)9-1-16-13-18(3-8-21(16)25)26(30,27(31,32)33)28(34,35)36/h2-8,10,13-15,22H,1,9,11-12H2 RQAFFTNZQNZEDK-UHFFFAOYSA-N 383141 US10273259, Example 852::US10711020, Example 852 Nuclear receptor ROR-gamma [262-507] 317 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383141 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383141&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679268 404852437 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931763 CC(=O)N1CCN(CC(=O)N2CC[C@@]3([C@H]2CCc2cc(ccc32)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c2ccc(F)cc2)CC1 InChI=1S/C29H29F8N3O4S/c1-18(41)39-14-12-38(13-15-39)17-25(42)40-11-10-26(45(43,44)22-6-4-21(30)5-7-22)23-8-3-20(16-19(23)2-9-24(26)40)27(31,28(32,33)34)29(35,36)37/h3-8,16,24H,2,9-15,17H2,1H3/t24-,26-/m1/s1 XRIKHAWQAIQWFH-AOYPEHQESA-N 383142 US10273259, Example 853::US10711020, Example 853 Nuclear receptor ROR-gamma [262-507] 176 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383142 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383142&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679279 404852438 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931764 OC1(CCS(=O)(=O)CC1)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)c(F)c1 InChI=1S/C27H24F9NO6S2/c28-19-5-3-17(14-20(19)29)45(42,43)24-7-10-37(22(38)23(39)8-11-44(40,41)12-9-23)21(24)6-1-15-13-16(2-4-18(15)24)25(30,26(31,32)33)27(34,35)36/h2-5,13-14,21,39H,1,6-12H2 NDHMELMUEHGMOW-UHFFFAOYSA-N 383143 US10273259, Example 854::US10711020, Example 854 Nuclear receptor ROR-gamma [262-507] 110 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383143 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383143&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679269 404852439 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931765 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)c(F)c1 InChI=1S/C29H26F9NO5S/c30-21-9-7-19(14-22(21)31)45(43,44)26-11-12-39(24(40)15-1-3-16(4-2-15)25(41)42)23(26)10-5-17-13-18(6-8-20(17)26)27(32,28(33,34)35)29(36,37)38/h6-9,13-16,23H,1-5,10-12H2,(H,41,42)/t15-,16-,23?,26? WQYJSKOPDWCZGC-KMLPXHMCSA-N 383144 US10273259, Example 855::US10711020, Example 855 Nuclear receptor ROR-gamma [262-507] 92.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383144 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383144&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679288 404852440 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931766 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)c1noc(=O)[nH]1 383145 US10273259, Example 856::US10711020, Example 856 Nuclear receptor ROR-gamma [262-507] 4434 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383145 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383145&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 145995618 404852441 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931767 CN1CC2N(CCC2(c2ccc(cc12)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(Cl)cc1)C(=O)C1CCS(=O)(=O)CC1 InChI=1S/C27H26ClF7N2O5S2/c1-36-15-22-24(44(41,42)19-5-3-18(28)4-6-19,10-11-37(22)23(38)16-8-12-43(39,40)13-9-16)20-7-2-17(14-21(20)36)25(29,26(30,31)32)27(33,34)35/h2-7,14,16,22H,8-13,15H2,1H3 KXBOUMSMUPGJDE-UHFFFAOYSA-N 383146 US10273259, Example 857::US10711020, Example 857 Nuclear receptor ROR-gamma [262-507] 229 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383146 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383146&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678820 404852442 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931768 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)N(C1CC1)C1CCOCC1 InChI=1S/C30H30F8N2O4S/c31-20-3-7-23(8-4-20)45(42,43)27-13-14-39(26(41)40(21-5-6-21)22-11-15-44-16-12-22)25(27)10-1-18-17-19(2-9-24(18)27)28(32,29(33,34)35)30(36,37)38/h2-4,7-9,17,21-22,25H,1,5-6,10-16H2/t25-,27-/m1/s1 ABIMSIIZXHTHEA-XNMGPUDCSA-N 383147 US10273259, Example 858::US10711020, Example 858 Nuclear receptor ROR-gamma [262-507] 305 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383147 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383147&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679214 404852443 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931769 CN1CC2N(CCC2(c2ccc(cc12)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(Cl)cc1)C(=O)C1(O)CCS(=O)(=O)CC1 InChI=1S/C27H26ClF7N2O6S2/c1-36-15-21-24(45(42,43)18-5-3-17(28)4-6-18,8-11-37(21)22(38)23(39)9-12-44(40,41)13-10-23)19-7-2-16(14-20(19)36)25(29,26(30,31)32)27(33,34)35/h2-7,14,21,39H,8-13,15H2,1H3 WTTWCNKDMVOPCF-UHFFFAOYSA-N 383148 US10273259, Example 859::US10711020, Example 859 Nuclear receptor ROR-gamma [262-507] 114 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383148 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383148&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679181 404852444 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931770 FC(F)(F)C(F)(c1ccc2c(CCC3N(CCC23S(=O)(=O)c2ccc(Cl)cc2)C(=O)c2noc(=O)[nH]2)c1)C(F)(F)F 383149 US10273259, Example 860::US10711020, Example 860 Nuclear receptor ROR-gamma [262-507] 6301 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383149 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383149&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 145995619 404852445 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931771 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)N1CCOCC1 InChI=1S/C26H24F8N2O4S/c27-18-3-5-19(6-4-18)41(38,39)23-9-10-36(22(37)35-11-13-40-14-12-35)21(23)8-1-16-15-17(2-7-20(16)23)24(28,25(29,30)31)26(32,33)34/h2-7,15,21H,1,8-14H2/t21-,23-/m1/s1 ASRNEDSRHDLYMM-FYYLOGMGSA-N 383150 US10273259, Example 861::US10711020, Example 861 Nuclear receptor ROR-gamma [262-507] 296 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383150 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383150&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679198 404852446 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931772 C[C@H]1C[C@H](CC[C@@H]1C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1)C(O)=O InChI=1S/C30H29F8NO5S/c1-16-14-18(26(41)42)2-9-22(16)25(40)39-13-12-27(45(43,44)21-7-5-20(31)6-8-21)23-10-4-19(15-17(23)3-11-24(27)39)28(32,29(33,34)35)30(36,37)38/h4-8,10,15-16,18,22,24H,2-3,9,11-14H2,1H3,(H,41,42)/t16-,18-,22-,24+,27+/m0/s1 JQORWGARJVSRBA-QVIYERQUSA-N 383151 US10273259, Example 862::US10711020, Example 862 Nuclear receptor ROR-gamma [262-507] 158 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383151 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383151&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678852 404852447 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931773 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)[C@@H]1CCC(=O)N1CCC#N InChI=1S/C29H25F8N3O4S/c30-19-4-6-20(7-5-19)45(43,44)26-12-15-40(25(42)22-9-11-24(41)39(22)14-1-13-38)23(26)10-2-17-16-18(3-8-21(17)26)27(31,28(32,33)34)29(35,36)37/h3-8,16,22-23H,1-2,9-12,14-15H2/t22-,23+,26+/m0/s1 XDDWLXGEQFTMIY-PPJWLVRDSA-N 383152 US10273259, Example 863::US10711020, Example 863 Nuclear receptor ROR-gamma [262-507] 79.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383152 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383152&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679209 404852448 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931774 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)NC1CCOCC11NC(=O)NC1=O InChI=1S/C29H26F8N4O6S/c30-17-3-5-18(6-4-17)48(45,46)26-10-11-41(24(44)38-20-9-12-47-14-25(20)22(42)39-23(43)40-25)21(26)8-1-15-13-16(2-7-19(15)26)27(31,28(32,33)34)29(35,36)37/h2-7,13,20-21H,1,8-12,14H2,(H,38,44)(H2,39,40,42,43)/t20?,21-,25?,26-/m1/s1 DAEFFTAFHRYSFX-AXOKKOEUSA-N 383153 US10273259, Example 864::US10711020, Example 864 Nuclear receptor ROR-gamma [262-507] 131 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383153 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383153&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 132123847 404852449 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931775 OC(=O)C1(CCS(=O)(=O)CC1)NC(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H26F8N2O7S2/c29-18-3-5-19(6-4-18)47(44,45)25-9-12-38(23(41)37-24(22(39)40)10-13-46(42,43)14-11-24)21(25)8-1-16-15-17(2-7-20(16)25)26(30,27(31,32)33)28(34,35)36/h2-7,15,21H,1,8-14H2,(H,37,41)(H,39,40)/t21-,25-/m1/s1 ZGQZBKNYGHOIRE-PXDATVDWSA-N 383154 US10273259, Example 865::US10711020, Example 865 Nuclear receptor ROR-gamma [262-507] 86.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383154 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383154&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679271 404852450 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931776 F[C@H]1C[C@H](N(CCC#N)C1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C29H26F9N3O3S/c30-19-4-6-21(7-5-19)45(43,44)26-10-13-41(25(42)23-15-20(31)16-40(23)12-1-11-39)24(26)9-2-17-14-18(3-8-22(17)26)27(32,28(33,34)35)29(36,37)38/h3-8,14,20,23-24H,1-2,9-10,12-13,15-16H2/t20-,23-,24+,26+/m0/s1 RDAKGQRSCIXLRS-ZUDIISFQSA-N 383155 US10273259, Example 866::US10711020, Example 866 Nuclear receptor ROR-gamma [262-507] 547 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383155 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383155&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679182 404852451 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931777 OC(=O)C12CCC(CC1)(CC2)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(Cl)c(Cl)c1 InChI=1S/C31H28Cl2F7NO5S/c32-21-5-3-19(16-22(21)33)47(45,46)28-13-14-41(24(42)26-7-10-27(11-8-26,12-9-26)25(43)44)23(28)6-1-17-15-18(2-4-20(17)28)29(34,30(35,36)37)31(38,39)40/h2-5,15-16,23H,1,6-14H2,(H,43,44) GWCNASWFBUUXFB-UHFFFAOYSA-N 383156 US10273259, Example 867::US10711020, Example 867 Nuclear receptor ROR-gamma [262-507] 318 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383156 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383156&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679191 404852452 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931778 CC(C)C(N(C1CCS(=O)(=O)C1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1)C(O)=O InChI=1S/C31H32F8N2O7S2/c1-17(2)25(26(42)43)41(21-11-14-49(45,46)16-21)27(44)40-13-12-28(50(47,48)22-7-5-20(32)6-8-22)23-9-4-19(15-18(23)3-10-24(28)40)29(33,30(34,35)36)31(37,38)39/h4-9,15,17,21,24-25H,3,10-14,16H2,1-2H3,(H,42,43)/t21?,24-,25?,28-/m1/s1 MYKUEHYCCDSATF-LNGFBGLASA-N 453903 US10711020, Example 868 Nuclear receptor ROR-gamma [262-507] 278 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=453903 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=453903&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679311 440969786 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931779 CN1[C@@H](CCCC1=O)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H26F8N2O4S/c1-37-21(3-2-4-23(37)39)24(40)38-14-13-25(43(41,42)19-9-7-18(29)8-10-19)20-11-6-17(15-16(20)5-12-22(25)38)26(30,27(31,32)33)28(34,35)36/h6-11,15,21-22H,2-5,12-14H2,1H3/t21-,22+,25+/m0/s1 MFQXWARSIFLBTN-SGIRGMQISA-N 383158 US10273259, Example 869::US10711020, Example 869 Nuclear receptor ROR-gamma [262-507] 292 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383158 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383158&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679285 404852454 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931780 F[C@H]1C[C@H](N(CC#N)C1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H24F9N3O3S/c29-18-3-5-20(6-4-18)44(42,43)25-9-11-40(24(41)22-14-19(30)15-39(22)12-10-38)23(25)8-1-16-13-17(2-7-21(16)25)26(31,27(32,33)34)28(35,36)37/h2-7,13,19,22-23H,1,8-9,11-12,14-15H2/t19-,22-,23+,25+/m0/s1 TXBQKEMSHREZLN-KNEWOZPHSA-N 383159 US10273259, Example 870::US10711020, Example 870 Nuclear receptor ROR-gamma [262-507] 162 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383159 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383159&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679199 404852455 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931781 CC(=O)N[C@@H]1CS(=O)(=O)C[C@H]1NC(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H27F8N3O6S2/c1-15(40)37-21-13-46(42,43)14-22(21)38-24(41)39-11-10-25(47(44,45)19-6-4-18(29)5-7-19)20-8-3-17(12-16(20)2-9-23(25)39)26(30,27(31,32)33)28(34,35)36/h3-8,12,21-23H,2,9-11,13-14H2,1H3,(H,37,40)(H,38,41)/t21-,22-,23-,25-/m1/s1 OTXBJQBFLDNACM-VWBWNGLSSA-N 383160 US10273259, Example 871::US10711020, Example 871 Nuclear receptor ROR-gamma [262-507] 215 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383160 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383160&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679296 404852456 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931782 Fc1ccc(cc1Cl)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1CCS(=O)(=O)CC1 InChI=1S/C27H24ClF8NO5S2/c28-20-14-18(3-5-21(20)29)44(41,42)24-9-10-37(23(38)15-7-11-43(39,40)12-8-15)22(24)6-1-16-13-17(2-4-19(16)24)25(30,26(31,32)33)27(34,35)36/h2-5,13-15,22H,1,6-12H2 HUJUOPROJGBEFI-UHFFFAOYSA-N 383161 US10273259, Example 872::US10711020, Example 872 Nuclear receptor ROR-gamma [262-507] 226 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383161 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383161&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678968 404852457 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931783 OC1(CCS(=O)(=O)CC1)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)c(Cl)c1 InChI=1S/C27H24ClF8NO6S2/c28-19-14-17(3-5-20(19)29)45(42,43)24-7-10-37(22(38)23(39)8-11-44(40,41)12-9-23)21(24)6-1-15-13-16(2-4-18(15)24)25(30,26(31,32)33)27(34,35)36/h2-5,13-14,21,39H,1,6-12H2 VZPXZYRWMQOUAG-UHFFFAOYSA-N 383162 US10273259, Example 873::US10711020, Example 873 Nuclear receptor ROR-gamma [262-507] 193 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383162 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383162&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679291 404852458 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931784 OC(=O)C12CCC(CC1)(CC2)C(=O)N1CCC2(C1CNc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(Cl)cc1 InChI=1S/C30H28ClF7N2O5S/c31-18-2-4-19(5-3-18)46(44,45)27-13-14-40(23(41)25-7-10-26(11-8-25,12-9-25)24(42)43)22(27)16-39-21-15-17(1-6-20(21)27)28(32,29(33,34)35)30(36,37)38/h1-6,15,22,39H,7-14,16H2,(H,42,43) DCOSMVLSMKCHGD-UHFFFAOYSA-N 383163 US10273259, Example 874::US10711020, Example 874 Nuclear receptor ROR-gamma [262-507] 423 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383163 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383163&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678925 404852459 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931785 CS(=O)(=O)N1CCN(CC(=O)N2CC[C@@]3([C@H]2CCc2cc(ccc32)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c2ccc(F)cc2)CC1 InChI=1S/C28H29F8N3O5S2/c1-45(41,42)38-14-12-37(13-15-38)17-24(40)39-11-10-25(46(43,44)21-6-4-20(29)5-7-21)22-8-3-19(16-18(22)2-9-23(25)39)26(30,27(31,32)33)28(34,35)36/h3-8,16,23H,2,9-15,17H2,1H3/t23-,25-/m1/s1 FNWNKMCQLZXHJH-ILBGXUMGSA-N 383164 US10273259, Example 875::US10711020, Example 875 Nuclear receptor ROR-gamma [262-507] 169 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383164 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383164&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678828 404852460 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931786 CC(=O)NC1CS(=O)(=O)CCC1NC(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C29H29F8N3O6S2/c1-16(41)38-23-15-47(43,44)13-10-22(23)39-25(42)40-12-11-26(48(45,46)20-6-4-19(30)5-7-20)21-8-3-18(14-17(21)2-9-24(26)40)27(31,28(32,33)34)29(35,36)37/h3-8,14,22-24H,2,9-13,15H2,1H3,(H,38,41)(H,39,42)/t22?,23?,24-,26-/m1/s1 UMHRTWJGSIYIHV-SFASGRJPSA-N 383165 US10273259, Example 876::US10273259, Example 878::US10711020, Example 878 Nuclear receptor ROR-gamma [262-507] 158 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383165 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383165&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678844 404852461 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931787 CC(C)(O)CN1[C@@H](C[C@H](F)C1=O)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C30H29F9N2O5S/c1-26(2,44)15-41-22(14-21(32)24(41)42)25(43)40-12-11-27(47(45,46)19-7-5-18(31)6-8-19)20-9-4-17(13-16(20)3-10-23(27)40)28(33,29(34,35)36)30(37,38)39/h4-9,13,21-23,44H,3,10-12,14-15H2,1-2H3/t21-,22-,23+,27+/m0/s1 NETWYXYMXZLUOG-OJXRJRMYSA-N 383166 US10273259, Example 877::US10711020, Example 877 Nuclear receptor ROR-gamma [262-507] 300 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383166 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383166&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678876 404852462 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931788 CC(=O)NC1CS(=O)(=O)CCC1NC(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C29H29F8N3O6S2/c1-16(41)38-23-15-47(43,44)13-10-22(23)39-25(42)40-12-11-26(48(45,46)20-6-4-19(30)5-7-20)21-8-3-18(14-17(21)2-9-24(26)40)27(31,28(32,33)34)29(35,36)37/h3-8,14,22-24H,2,9-13,15H2,1H3,(H,38,41)(H,39,42)/t22?,23?,24-,26-/m1/s1 UMHRTWJGSIYIHV-SFASGRJPSA-N 383165 US10273259, Example 876::US10273259, Example 878::US10711020, Example 878 Nuclear receptor ROR-gamma [262-507] 172 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383165 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383165&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678844 404852461 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931789 CN(CC(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1)C1CCS(=O)(=O)C1 InChI=1S/C28H28F8N2O5S2/c1-37(20-10-13-44(40,41)16-20)15-24(39)38-12-11-25(45(42,43)21-6-4-19(29)5-7-21)22-8-3-18(14-17(22)2-9-23(25)38)26(30,27(31,32)33)28(34,35)36/h3-8,14,20,23H,2,9-13,15-16H2,1H3/t20?,23-,25-/m1/s1 RAUACNVWKWOTAA-ALRSMIOZSA-N 383168 US10273259, Example 879::US10711020, Example 879 Nuclear receptor ROR-gamma [262-507] 256 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383168 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383168&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 132123796 404852463 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931790 Cc1ccc(cc1F)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)[C@H]1CC[C@@H](CC1)C(O)=O InChI=1S/C30H29F8NO5S/c1-16-2-9-21(15-23(16)31)45(43,44)27-12-13-39(25(40)17-3-5-18(6-4-17)26(41)42)24(27)11-7-19-14-20(8-10-22(19)27)28(32,29(33,34)35)30(36,37)38/h2,8-10,14-15,17-18,24H,3-7,11-13H2,1H3,(H,41,42)/t17-,18-,24?,27? PDGKINUZZURWRV-VRSFHCCXSA-N 383169 US10273259, Example 880::US10711020, Example 880 Nuclear receptor ROR-gamma [262-507] 382 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383169 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383169&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679210 404852464 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931791 CN1CC2N(CCC2(c2ccc(cc12)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(Cl)cc1)C(=O)C12CCC(CC1)(CC2)C(O)=O InChI=1S/C31H30ClF7N2O5S/c1-40-17-23-28(47(45,46)20-5-3-19(32)4-6-20,21-7-2-18(16-22(21)40)29(33,30(34,35)36)31(37,38)39)14-15-41(23)24(42)26-8-11-27(12-9-26,13-10-26)25(43)44/h2-7,16,23H,8-15,17H2,1H3,(H,43,44) HQOWOHXMRYGROC-UHFFFAOYSA-N 383170 US10273259, Example 881::US10711020, Example 881 Nuclear receptor ROR-gamma [262-507] 191 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383170 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383170&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679221 404852465 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931792 FC(F)(F)C(F)(c1ccc2c(CCC3N(CCC23S(=O)(=O)c2ccc(Cl)cc2)C(=O)[C@@H]2CCC(=O)N2CCC#N)c1)C(F)(F)F InChI=1S/C29H25ClF7N3O4S/c30-19-4-6-20(7-5-19)45(43,44)26-12-15-40(25(42)22-9-11-24(41)39(22)14-1-13-38)23(26)10-2-17-16-18(3-8-21(17)26)27(31,28(32,33)34)29(35,36)37/h3-8,16,22-23H,1-2,9-12,14-15H2/t22-,23?,26?/m0/s1 HSVGOEREHCXCOP-MFNHVEPQSA-N 383171 US10273259, Example 882::US10711020, Example 882 Nuclear receptor ROR-gamma [262-507] 135 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383171 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383171&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678974 404852466 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931009 Cc1ccc(cc1Cl)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)[C@H]1CC[C@@H](CC1)C(O)=O InChI=1S/C30H29ClF7NO5S/c1-16-2-9-21(15-23(16)31)45(43,44)27-12-13-39(25(40)17-3-5-18(6-4-17)26(41)42)24(27)11-7-19-14-20(8-10-22(19)27)28(32,29(33,34)35)30(36,37)38/h2,8-10,14-15,17-18,24H,3-7,11-13H2,1H3,(H,41,42)/t17-,18-,24?,27? DRMBQFRPYKUROH-VRSFHCCXSA-N 382385 US10273259, Example 97::US10711020, Example 97 Nuclear receptor ROR-gamma [262-507] 146 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382385 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382385&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678587 404851755 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931010 Cc1ccc(cc1Cl)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)[C@@]1(F)CC[C@@H](CC1)C(O)=O InChI=1S/C30H28ClF8NO5S/c1-16-2-5-20(15-22(16)31)46(44,45)27-12-13-40(25(43)26(32)10-8-17(9-11-26)24(41)42)23(27)7-3-18-14-19(4-6-21(18)27)28(33,29(34,35)36)30(37,38)39/h2,4-6,14-15,17,23H,3,7-13H2,1H3,(H,41,42)/t17-,23?,26+,27? KEAQWRPTKBMNPV-MTOUGUCQSA-N 382386 US10273259, Example 98::US10711020, Example 98 Nuclear receptor ROR-gamma [262-507] 133 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382386 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382386&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679006 404851756 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931011 Cc1ccc(cc1Cl)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)[C@H]1CC[C@@](C)(CC1)C(O)=O InChI=1S/C31H31ClF7NO5S/c1-17-3-6-21(16-23(17)32)46(44,45)28-13-14-40(25(41)18-9-11-27(2,12-10-18)26(42)43)24(28)8-4-19-15-20(5-7-22(19)28)29(33,30(34,35)36)31(37,38)39/h3,5-7,15-16,18,24H,4,8-14H2,1-2H3,(H,42,43)/t18-,24?,27-,28? OLZARMZJSUUYAH-GLMFJJLTSA-N 382387 US10273259, Example 99::US10711020, Example 99 Nuclear receptor ROR-gamma [262-507] 84.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382387 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382387&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678995 404851757 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931012 Cc1ccc(cc1Cl)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1(O)CCS(=O)(=O)CC1 InChI=1S/C28H27ClF7NO6S2/c1-16-2-5-19(15-21(16)29)45(42,43)25-8-11-37(23(38)24(39)9-12-44(40,41)13-10-24)22(25)7-3-17-14-18(4-6-20(17)25)26(30,27(31,32)33)28(34,35)36/h2,4-6,14-15,22,39H,3,7-13H2,1H3 NHMKCWFDDYHIQL-UHFFFAOYSA-N 382388 US10273259, Example 100::US10711020, Example 100 Nuclear receptor ROR-gamma [262-507] 175 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382388 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382388&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678873 404851758 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931013 Cc1ccc(cc1Cl)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)[C@H]1CC[C@@](F)(CC1)C(O)=O InChI=1S/C30H28ClF8NO5S/c1-16-2-5-20(15-22(16)31)46(44,45)27-12-13-40(24(41)17-8-10-26(32,11-9-17)25(42)43)23(27)7-3-18-14-19(4-6-21(18)27)28(33,29(34,35)36)30(37,38)39/h2,4-6,14-15,17,23H,3,7-13H2,1H3,(H,42,43)/t17-,23?,26+,27? WBFMVNPIZFZVHK-MTOUGUCQSA-N 382389 US10273259, Example 101::US10711020, Example 101 Nuclear receptor ROR-gamma [262-507] 163 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382389 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382389&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678886 404851759 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931014 Cc1ccc(cc1Cl)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C12CCC(CC1)(CC2)C(O)=O InChI=1S/C32H31ClF7NO5S/c1-18-2-5-21(17-23(18)33)47(45,46)29-14-15-41(25(42)27-8-11-28(12-9-27,13-10-27)26(43)44)24(29)7-3-19-16-20(4-6-22(19)29)30(34,31(35,36)37)32(38,39)40/h2,4-6,16-17,24H,3,7-15H2,1H3,(H,43,44) NXBJARFKJWFEIZ-UHFFFAOYSA-N 382390 US10273259, Example 102::US10711020, Example 102 Nuclear receptor ROR-gamma [262-507] 124 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382390 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382390&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679008 404851760 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931015 Cc1ccc(cc1Cl)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)[C@@]1(O)CC[C@@H](CC1)C(O)=O InChI=1S/C30H29ClF7NO6S/c1-16-2-5-20(15-22(16)31)46(44,45)27-12-13-39(25(42)26(43)10-8-17(9-11-26)24(40)41)23(27)7-3-18-14-19(4-6-21(18)27)28(32,29(33,34)35)30(36,37)38/h2,4-6,14-15,17,23,43H,3,7-13H2,1H3,(H,40,41)/t17-,23?,26+,27? RPNPBNYDSJZIET-MTOUGUCQSA-N 382391 US10273259, Example 103::US10711020, Example 103 Nuclear receptor ROR-gamma [262-507] 108 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382391 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382391&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678998 404851761 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931016 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(cc1)C(F)(F)F InChI=1S/C30H27F10NO5S/c31-27(29(35,36)37,30(38,39)40)20-8-11-22-18(15-20)5-12-23-26(22,47(45,46)21-9-6-19(7-10-21)28(32,33)34)13-14-41(23)24(42)16-1-3-17(4-2-16)25(43)44/h6-11,15-17,23H,1-5,12-14H2,(H,43,44)/t16-,17-,23?,26? JWCSFLGFDNXEQO-LRVXPCDCSA-N 382392 US10273259, Example 104::US10711020, Example 104 Nuclear receptor ROR-gamma [262-507] 263 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382392 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382392&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 132123479 404851762 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931017 CC1(CCS(=O)(=O)CC1)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(cc1)C(F)(F)F InChI=1S/C29H27F10NO5S2/c1-24(11-14-46(42,43)15-12-24)23(41)40-13-10-25(47(44,45)20-6-3-18(4-7-20)27(31,32)33)21-8-5-19(16-17(21)2-9-22(25)40)26(30,28(34,35)36)29(37,38)39/h3-8,16,22H,2,9-15H2,1H3 WHOHSHCFKPBOFB-UHFFFAOYSA-N 382393 US10273259, Example 105::US10711020, Example 105 Nuclear receptor ROR-gamma [262-507] 230 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382393 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382393&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 132123475 404851763 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931018 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)Cc1ccccc1 InChI=1S/C30H30F7NO5S/c31-28(29(32,33)34,30(35,36)37)22-11-12-23-21(16-22)10-13-24-27(23,44(42,43)17-18-4-2-1-3-5-18)14-15-38(24)25(39)19-6-8-20(9-7-19)26(40)41/h1-5,11-12,16,19-20,24H,6-10,13-15,17H2,(H,40,41)/t19-,20-,24?,27? RTRLDILTCFOVAH-QJAGXIKFSA-N 382394 US10273259, Example 106::US10711020, Example 106 Nuclear receptor ROR-gamma [262-507] 55.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382394 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382394&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678792 404851764 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931019 FC(F)(F)C(F)(c1ccc2c(CCC3N(CCC23S(=O)(=O)Cc2ccccc2)C(=O)C2CCS(=O)(=O)CC2)c1)C(F)(F)F InChI=1S/C28H28F7NO5S2/c29-26(27(30,31)32,28(33,34)35)21-7-8-22-20(16-21)6-9-23-25(22,43(40,41)17-18-4-2-1-3-5-18)12-13-36(23)24(37)19-10-14-42(38,39)15-11-19/h1-5,7-8,16,19,23H,6,9-15,17H2 RKKBHGMQMCNGAE-UHFFFAOYSA-N 382395 US10273259, Example 107::US10711020, Example 107 Nuclear receptor ROR-gamma [262-507] 51.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382395 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382395&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679000 404851765 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931020 OC(=O)C12CCC(CC1)(CC2)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)Cc1ccccc1 InChI=1S/C32H32F7NO5S/c33-30(31(34,35)36,32(37,38)39)22-7-8-23-21(18-22)6-9-24-29(23,46(44,45)19-20-4-2-1-3-5-20)16-17-40(24)25(41)27-10-13-28(14-11-27,15-12-27)26(42)43/h1-5,7-8,18,24H,6,9-17,19H2,(H,42,43) GSXDSWBPTORMQS-UHFFFAOYSA-N 382396 US10273259, Example 108::US10711020, Example 108 Nuclear receptor ROR-gamma [262-507] 50.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382396 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382396&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678588 404851766 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931021 OC(=O)C12CCC(CC1)(CC2)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(cc1)C(F)(F)F InChI=1S/C32H29F10NO5S/c33-29(31(37,38)39,32(40,41)42)20-4-7-22-18(17-20)1-8-23-28(22,49(47,48)21-5-2-19(3-6-21)30(34,35)36)15-16-43(23)24(44)26-9-12-27(13-10-26,14-11-26)25(45)46/h2-7,17,23H,1,8-16H2,(H,45,46) SSFHOCAPGURBBW-UHFFFAOYSA-N 382397 US10273259, Example 109::US10711020, Example 109 Nuclear receptor ROR-gamma [262-507] 74.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382397 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382397&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 132123824 404851767 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931022 OC1(CCS(=O)(=O)CC1)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(cc1)C(F)(F)F InChI=1S/C28H25F10NO6S2/c29-25(27(33,34)35,28(36,37)38)18-4-7-20-16(15-18)1-8-21-24(20,47(44,45)19-5-2-17(3-6-19)26(30,31)32)9-12-39(21)22(40)23(41)10-13-46(42,43)14-11-23/h2-7,15,21,41H,1,8-14H2 IRRSKOHWHZTXSS-UHFFFAOYSA-N 382398 US10273259, Example 110::US10711020, Example 110 Nuclear receptor ROR-gamma [262-507] 93.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382398 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382398&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 132123765 404851768 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931023 CC(C)c1ccc(cc1)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)[C@H]1CC[C@@](F)(CC1)C(O)=O InChI=1S/C32H33F8NO5S/c1-18(2)19-3-7-23(8-4-19)47(45,46)29-15-16-41(26(42)20-11-13-28(33,14-12-20)27(43)44)25(29)10-5-21-17-22(6-9-24(21)29)30(34,31(35,36)37)32(38,39)40/h3-4,6-9,17-18,20,25H,5,10-16H2,1-2H3,(H,43,44)/t20-,25?,28+,29? IUMIVCLDNMESOE-GZAOQYKUSA-N 382399 US10273259, Example 111::US10711020, Example 111 Nuclear receptor ROR-gamma [262-507] 58.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382399 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382399&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 132123772 404851769 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931024 CC(C)c1ccc(cc1)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)[C@@]1(F)CC[C@@H](CC1)C(O)=O InChI=1S/C32H33F8NO5S/c1-18(2)19-3-7-23(8-4-19)47(45,46)29-15-16-41(27(44)28(33)13-11-20(12-14-28)26(42)43)25(29)10-5-21-17-22(6-9-24(21)29)30(34,31(35,36)37)32(38,39)40/h3-4,6-9,17-18,20,25H,5,10-16H2,1-2H3,(H,42,43)/t20-,25?,28+,29? VXFIPBDLADOJIH-GZAOQYKUSA-N 382400 US10273259, Example 112::US10711020, Example 112 Nuclear receptor ROR-gamma [262-507] 90.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382400 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382400&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 132123825 404851770 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931025 CC(C)c1ccc(cc1)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)[C@H]1CC[C@@H](CC1)C(O)=O InChI=1S/C32H34F7NO5S/c1-18(2)19-7-11-24(12-8-19)46(44,45)29-15-16-40(27(41)20-3-5-21(6-4-20)28(42)43)26(29)14-9-22-17-23(10-13-25(22)29)30(33,31(34,35)36)32(37,38)39/h7-8,10-13,17-18,20-21,26H,3-6,9,14-16H2,1-2H3,(H,42,43)/t20-,21-,26?,29? QFVFNFDGHMYBIJ-ZAOANWOTSA-N 382401 US10273259, Example 113::US10711020, Example 113 Nuclear receptor ROR-gamma [262-507] 118 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382401 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382401&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 132123480 404851771 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931026 CC(C)c1ccc(cc1)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C12CCC(CC1)(CC2)C(O)=O InChI=1S/C34H36F7NO5S/c1-20(2)21-3-7-24(8-4-21)48(46,47)31-17-18-42(27(43)29-11-14-30(15-12-29,16-13-29)28(44)45)26(31)10-5-22-19-23(6-9-25(22)31)32(35,33(36,37)38)34(39,40)41/h3-4,6-9,19-20,26H,5,10-18H2,1-2H3,(H,44,45) MECCTNDTONQWLK-UHFFFAOYSA-N 382402 US10273259, Example 114::US10711020, Example 114 Nuclear receptor ROR-gamma [262-507] 73.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382402 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382402&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 132123722 404851772 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931027 Cc1cc(ccc1Cl)S(=O)(=O)C12CCN(C1CCc1cc(I)ccc21)C(=O)[C@H]1CC[C@@H](CC1)C(O)=O InChI=1S/C27H29ClINO5S/c1-16-14-21(8-10-23(16)28)36(34,35)27-12-13-30(25(31)17-2-4-18(5-3-17)26(32)33)24(27)11-6-19-15-20(29)7-9-22(19)27/h7-10,14-15,17-18,24H,2-6,11-13H2,1H3,(H,32,33)/t17-,18-,24?,27? GOOKSKCEQCJEFL-VRSFHCCXSA-N 382403 US10273259, Example 115::US10711020, Example 115 Nuclear receptor ROR-gamma [262-507] 26.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382403 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382403&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678900 404851773 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931028 FC(F)(F)C(F)(c1ccc2c(CCC3N(CCC23S(=O)(=O)c2ccccn2)C(=O)C2CCS(=O)(=O)CC2)c1)C(F)(F)F InChI=1S/C26H25F7N2O5S2/c27-24(25(28,29)30,26(31,32)33)18-5-6-19-17(15-18)4-7-20-23(19,42(39,40)21-3-1-2-11-34-21)10-12-35(20)22(36)16-8-13-41(37,38)14-9-16/h1-3,5-6,11,15-16,20H,4,7-10,12-14H2 GMYAHKGUKTUYTI-UHFFFAOYSA-N 382404 US10273259, Example 116::US10273259, Example 181::US10711020, Example 116 Nuclear receptor ROR-gamma [262-507] 26.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382404 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382404&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678791 404851774 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931029 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccccn1 InChI=1S/C28H27F7N2O5S/c29-26(27(30,31)32,28(33,34)35)19-9-10-20-18(15-19)8-11-21-25(20,43(41,42)22-3-1-2-13-36-22)12-14-37(21)23(38)16-4-6-17(7-5-16)24(39)40/h1-3,9-10,13,15-17,21H,4-8,11-12,14H2,(H,39,40)/t16-,17-,21?,25? CPBKYNQJGQJOLW-QWDHGTDNSA-N 382405 US10273259, Example 117::US10711020, Example 117 Nuclear receptor ROR-gamma [262-507] 56.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382405 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382405&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678590 404851775 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931030 OC(=O)C12CCC(CC1)(CC2)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccccn1 InChI=1S/C30H29F7N2O5S/c31-28(29(32,33)34,30(35,36)37)19-5-6-20-18(17-19)4-7-21-27(20,45(43,44)22-3-1-2-15-38-22)14-16-39(21)23(40)25-8-11-26(12-9-25,13-10-25)24(41)42/h1-3,5-6,15,17,21H,4,7-14,16H2,(H,41,42) QDEUATGCIBILHF-UHFFFAOYSA-N 382406 US10273259, Example 118::US10711020, Example 118 Nuclear receptor ROR-gamma [262-507] 71.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382406 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382406&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679014 404851776 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931031 CCc1ccc(cc1)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)[C@@]1(F)CC[C@@H](CC1)C(O)=O InChI=1S/C31H31F8NO5S/c1-2-18-3-7-22(8-4-18)46(44,45)28-15-16-40(26(43)27(32)13-11-19(12-14-27)25(41)42)24(28)10-5-20-17-21(6-9-23(20)28)29(33,30(34,35)36)31(37,38)39/h3-4,6-9,17,19,24H,2,5,10-16H2,1H3,(H,41,42)/t19-,24?,27+,28? LLIXOENZWMJLPD-SDUUHUFGSA-N 382407 US10273259, Example 119::US10711020, Example 119 Nuclear receptor ROR-gamma [262-507] 58.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382407 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382407&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679005 404851777 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931032 CCc1ccc(cc1)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)[C@H]1CC[C@@](F)(CC1)C(O)=O InChI=1S/C31H31F8NO5S/c1-2-18-3-7-22(8-4-18)46(44,45)28-15-16-40(25(41)19-11-13-27(32,14-12-19)26(42)43)24(28)10-5-20-17-21(6-9-23(20)28)29(33,30(34,35)36)31(37,38)39/h3-4,6-9,17,19,24H,2,5,10-16H2,1H3,(H,42,43)/t19-,24?,27+,28? GJSBXBJHUCKEAU-SDUUHUFGSA-N 382408 US10273259, Example 120::US10711020, Example 120 Nuclear receptor ROR-gamma [262-507] 83.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382408 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382408&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678664 404851778 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931033 CCc1ccc(cc1)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1(O)CCS(=O)(=O)CC1 InChI=1S/C29H30F7NO6S2/c1-2-18-3-7-21(8-4-18)45(42,43)26-11-14-37(24(38)25(39)12-15-44(40,41)16-13-25)23(26)10-5-19-17-20(6-9-22(19)26)27(30,28(31,32)33)29(34,35)36/h3-4,6-9,17,23,39H,2,5,10-16H2,1H3 OEUGOJRLLLPCDD-UHFFFAOYSA-N 382409 US10273259, Example 121::US10711020, Example 121 Nuclear receptor ROR-gamma [262-507] 51.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382409 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382409&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678593 404851779 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931034 CCc1ccc(cc1)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)[C@H]1CC[C@@H](CC1)C(O)=O InChI=1S/C31H32F7NO5S/c1-2-18-3-11-23(12-4-18)45(43,44)28-15-16-39(26(40)19-5-7-20(8-6-19)27(41)42)25(28)14-9-21-17-22(10-13-24(21)28)29(32,30(33,34)35)31(36,37)38/h3-4,10-13,17,19-20,25H,2,5-9,14-16H2,1H3,(H,41,42)/t19-,20-,25?,28? GSIIMBVMJFEAKF-IUKKCNNLSA-N 382410 US10273259, Example 122::US10711020, Example 122 Nuclear receptor ROR-gamma [262-507] 127 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382410 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382410&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678898 404851780 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931035 CCc1ccc(cc1)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C12CCC(CC1)(CC2)C(O)=O InChI=1S/C33H34F7NO5S/c1-2-20-3-7-23(8-4-20)47(45,46)30-17-18-41(26(42)28-11-14-29(15-12-28,16-13-28)27(43)44)25(30)10-5-21-19-22(6-9-24(21)30)31(34,32(35,36)37)33(38,39)40/h3-4,6-9,19,25H,2,5,10-18H2,1H3,(H,43,44) LNZNBDGBDUSQDR-UHFFFAOYSA-N 382411 US10273259, Example 123::US10711020, Example 123 Nuclear receptor ROR-gamma [262-507] 43.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382411 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382411&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678666 404851781 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931036 CC(C)c1ccc(cc1)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1(O)CCS(=O)(=O)CC1 InChI=1S/C30H32F7NO6S2/c1-18(2)19-3-7-22(8-4-19)46(43,44)27-11-14-38(25(39)26(40)12-15-45(41,42)16-13-26)24(27)10-5-20-17-21(6-9-23(20)27)28(31,29(32,33)34)30(35,36)37/h3-4,6-9,17-18,24,40H,5,10-16H2,1-2H3 JPWRMQFWCRVQBG-UHFFFAOYSA-N 382412 US10273259, Example 124::US10711020, Example 124 Nuclear receptor ROR-gamma [262-507] 188 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382412 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382412&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679010 404851782 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931037 CCc1ccc(cc1)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)[C@@]1(O)CC[C@@H](CC1)C(O)=O InChI=1S/C31H32F7NO6S/c1-2-18-3-7-22(8-4-18)46(44,45)28-15-16-39(26(42)27(43)13-11-19(12-14-27)25(40)41)24(28)10-5-20-17-21(6-9-23(20)28)29(32,30(33,34)35)31(36,37)38/h3-4,6-9,17,19,24,43H,2,5,10-16H2,1H3,(H,40,41)/t19-,24?,27+,28? MYYLAIRAHITLDJ-SDUUHUFGSA-N 382413 US10273259, Example 125::US10711020, Example 125 Nuclear receptor ROR-gamma [262-507] 52.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382413 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382413&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678594 404851783 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931038 OC(=O)[C@@]1(F)CC[C@@H](CC1)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccccn1 InChI=1S/C28H26F8N2O5S/c29-24(23(40)41)10-8-16(9-11-24)22(39)38-14-12-25(44(42,43)21-3-1-2-13-37-21)19-6-5-18(15-17(19)4-7-20(25)38)26(30,27(31,32)33)28(34,35)36/h1-3,5-6,13,15-16,20H,4,7-12,14H2,(H,40,41)/t16-,20?,24+,25? FEXHUAMBJOPDLF-DWOZHRLGSA-N 382414 US10273259, Example 126::US10711020, Example 126 Nuclear receptor ROR-gamma [262-507] 109 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382414 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382414&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678794 404851784 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931039 OC(=O)[C@H]1CC[C@@](O)(CC1)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccccn1 InChI=1S/C28H27F7N2O6S/c29-26(27(30,31)32,28(33,34)35)18-5-6-19-17(15-18)4-7-20-25(19,44(42,43)21-3-1-2-13-36-21)12-14-37(20)23(40)24(41)10-8-16(9-11-24)22(38)39/h1-3,5-6,13,15-16,20,41H,4,7-12,14H2,(H,38,39)/t16-,20?,24+,25? PIIPQVLYLRRHBF-DWOZHRLGSA-N 382415 US10273259, Example 127::US10711020, Example 127 Nuclear receptor ROR-gamma [262-507] 44.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382415 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382415&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678797 404851785 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931040 OC(=O)[C@H]1CC[C@@](F)(CC1)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccccn1 InChI=1S/C28H26F8N2O5S/c29-24(10-8-16(9-11-24)22(39)40)23(41)38-14-12-25(44(42,43)21-3-1-2-13-37-21)19-6-5-18(15-17(19)4-7-20(25)38)26(30,27(31,32)33)28(34,35)36/h1-3,5-6,13,15-16,20H,4,7-12,14H2,(H,39,40)/t16-,20?,24+,25? RWHOTDWUUJYFAK-DWOZHRLGSA-N 382416 US10273259, Example 128::US10711020, Example 128 Nuclear receptor ROR-gamma [262-507] 82.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382416 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382416&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678667 404851786 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931041 CC1(CCS(=O)(=O)CC1)C(=O)N1CCC2(C1COc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C27H25F8NO6S2/c1-23(9-12-43(38,39)13-10-23)22(37)36-11-8-24(44(40,41)18-5-3-17(28)4-6-18)19-7-2-16(14-20(19)42-15-21(24)36)25(29,26(30,31)32)27(33,34)35/h2-7,14,21H,8-13,15H2,1H3 LUDHLKCTEDXNHC-UHFFFAOYSA-N 382417 US10273259, Example 129::US10711020, Example 129 Nuclear receptor ROR-gamma [262-507] 42.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382417 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382417&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678799 404851787 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931042 OC(=O)[C@@]1(F)CC[C@@H](CC1)C(=O)N1CCC2(C1COc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H24F9NO6S/c29-17-2-4-18(5-3-17)45(42,43)25-11-12-38(22(39)15-7-9-24(30,10-8-15)23(40)41)21(25)14-44-20-13-16(1-6-19(20)25)26(31,27(32,33)34)28(35,36)37/h1-6,13,15,21H,7-12,14H2,(H,40,41)/t15-,21?,24+,25? PSWRMIOHPUAQEO-DNNXONSASA-N 382418 US10273259, Example 130::US10711020, Example 130 Nuclear receptor ROR-gamma [262-507] 94.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382418 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382418&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678671 404851788 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931043 C[C@@]1(CC[C@@H](CC1)C(=O)N1CCC2(C1COc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1)C(O)=O InChI=1S/C29H27F8NO6S/c1-25(24(40)41)10-8-16(9-11-25)23(39)38-13-12-26(45(42,43)19-5-3-18(30)4-6-19)20-7-2-17(14-21(20)44-15-22(26)38)27(31,28(32,33)34)29(35,36)37/h2-7,14,16,22H,8-13,15H2,1H3,(H,40,41)/t16-,22?,25-,26? ALHXVPACIBAJJZ-FVSSTLBOSA-N 382419 US10273259, Example 131::US10711020, Example 131 Nuclear receptor ROR-gamma [262-507] 79.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382419 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382419&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678596 404851789 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931044 OC(=O)[C@H]1CC[C@@](F)(CC1)C(=O)N1CCC2(C1COc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H24F9NO6S/c29-17-2-4-18(5-3-17)45(42,43)25-11-12-38(23(41)24(30)9-7-15(8-10-24)22(39)40)21(25)14-44-20-13-16(1-6-19(20)25)26(31,27(32,33)34)28(35,36)37/h1-6,13,15,21H,7-12,14H2,(H,39,40)/t15-,21?,24+,25? HPKDLYXZFDREEU-DNNXONSASA-N 382420 US10273259, Example 132::US10711020, Example 132 Nuclear receptor ROR-gamma [262-507] 97.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382420 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382420&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678669 404851790 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931045 OC1(CCS(=O)(=O)CC1)C(=O)N1CCC2(C1COc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C26H23F8NO7S2/c27-16-2-4-17(5-3-16)44(40,41)23-7-10-35(21(36)22(37)8-11-43(38,39)12-9-22)20(23)14-42-19-13-15(1-6-18(19)23)24(28,25(29,30)31)26(32,33)34/h1-6,13,20,37H,7-12,14H2 KIQQPHOZVGKIIP-UHFFFAOYSA-N 382421 US10273259, Example 133::US10711020, Example 133 Nuclear receptor ROR-gamma [262-507] 76.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382421 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382421&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678672 404851791 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931046 OC(=O)C12CCC(CC1)(CC2)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccncc1 InChI=1S/C30H29F7N2O5S/c31-28(29(32,33)34,30(35,36)37)19-2-3-21-18(17-19)1-4-22-27(21,45(43,44)20-5-14-38-15-6-20)13-16-39(22)23(40)25-7-10-26(11-8-25,12-9-25)24(41)42/h2-3,5-6,14-15,17,22H,1,4,7-13,16H2,(H,41,42) KKBQMUJYOPVKSP-UHFFFAOYSA-N 382422 US10273259, Example 134::US10711020, Example 134 Nuclear receptor ROR-gamma [262-507] 48.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382422 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382422&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678901 404851792 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931047 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccncc1 InChI=1S/C28H27F7N2O5S/c29-26(27(30,31)32,28(33,34)35)19-6-7-21-18(15-19)5-8-22-25(21,43(41,42)20-9-12-36-13-10-20)11-14-37(22)23(38)16-1-3-17(4-2-16)24(39)40/h6-7,9-10,12-13,15-17,22H,1-5,8,11,14H2,(H,39,40)/t16-,17-,22?,25? ZNIXQMTYBBPOIP-FECXEKGZSA-N 382423 US10273259, Example 135::US10711020, Example 135 Nuclear receptor ROR-gamma [262-507] 110 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382423 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382423&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678801 404851793 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931048 OC(=O)[C@H]1CC[C@@](O)(CC1)C(=O)N1CCC2(C1COc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H25F8NO7S/c29-17-2-4-18(5-3-17)45(42,43)25-11-12-37(23(40)24(41)9-7-15(8-10-24)22(38)39)21(25)14-44-20-13-16(1-6-19(20)25)26(30,27(31,32)33)28(34,35)36/h1-6,13,15,21,41H,7-12,14H2,(H,38,39)/t15-,21?,24+,25? VVRAIPOLXFJASA-DNNXONSASA-N 382424 US10273259, Example 136::US10711020, Example 136 Nuclear receptor ROR-gamma [262-507] 44.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382424 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382424&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678803 404851794 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931049 CC(C)(O)c1ccc(cc1)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)[C@H]1CC[C@@H](CC1)C(O)=O InChI=1S/C32H34F7NO6S/c1-28(2,44)21-8-11-23(12-9-21)47(45,46)29-15-16-40(26(41)18-3-5-19(6-4-18)27(42)43)25(29)14-7-20-17-22(10-13-24(20)29)30(33,31(34,35)36)32(37,38)39/h8-13,17-19,25,44H,3-7,14-16H2,1-2H3,(H,42,43)/t18-,19-,25?,29? CWTGBYJIEXPUAR-XCZPLDPBSA-N 382425 US10273259, Example 137::US10711020, Example 137 Nuclear receptor ROR-gamma [262-507] 671 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382425 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382425&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678674 404851795 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931050 C[C@@]1(CC[C@@H](CC1)C(O)=O)C(=O)N1CCC2(C1COc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C29H27F8NO6S/c1-25(10-8-16(9-11-25)23(39)40)24(41)38-13-12-26(45(42,43)19-5-3-18(30)4-6-19)20-7-2-17(14-21(20)44-15-22(26)38)27(31,28(32,33)34)29(35,36)37/h2-7,14,16,22H,8-13,15H2,1H3,(H,39,40)/t16-,22?,25-,26? CHHAKPIZQFGHMC-FVSSTLBOSA-N 382426 US10273259, Example 138::US10711020, Example 138 Nuclear receptor ROR-gamma [262-507] 65.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382426 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382426&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679012 404851796 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931051 CC(C)(O)c1ccc(cc1)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C12CCC(CC1)(CC2)C(O)=O InChI=1S/C34H36F7NO6S/c1-28(2,46)21-4-7-23(8-5-21)49(47,48)31-17-18-42(26(43)29-11-14-30(15-12-29,16-13-29)27(44)45)25(31)10-3-20-19-22(6-9-24(20)31)32(35,33(36,37)38)34(39,40)41/h4-9,19,25,46H,3,10-18H2,1-2H3,(H,44,45) MWDJDMGQUPUSTR-UHFFFAOYSA-N 382427 US10273259, Example 139::US10711020, Example 139 Nuclear receptor ROR-gamma [262-507] 347 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382427 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382427&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678680 404851797 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931052 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(cc1)C1CC1 InChI=1S/C32H32F7NO5S/c33-30(31(34,35)36,32(37,38)39)23-10-13-25-22(17-23)9-14-26-29(25,46(44,45)24-11-7-19(8-12-24)18-1-2-18)15-16-40(26)27(41)20-3-5-21(6-4-20)28(42)43/h7-8,10-13,17-18,20-21,26H,1-6,9,14-16H2,(H,42,43)/t20-,21-,26?,29? ZQAYVANPYIPETO-ZAOANWOTSA-N 382429 US10273259, Example 140::US10711020, Example 140 Nuclear receptor ROR-gamma [262-507] 61.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382429 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382429&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678805 404851799 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931053 Cc1ccc(cc1)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C12CCC(CC1)(CC2)C(O)=O InChI=1S/C32H32F7NO5S/c1-19-2-6-22(7-3-19)46(44,45)29-16-17-40(25(41)27-10-13-28(14-11-27,15-12-27)26(42)43)24(29)9-4-20-18-21(5-8-23(20)29)30(33,31(34,35)36)32(37,38)39/h2-3,5-8,18,24H,4,9-17H2,1H3,(H,42,43) SNKGBBUIANWTAE-UHFFFAOYSA-N 382233 US10273259, Example 141::US10273259, Example 20::US10711020, Example 141 Nuclear receptor ROR-gamma [262-507] 96.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382233 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382233&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678830 404851606 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931054 Cc1ccc(cc1)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)[C@@]1(O)CC[C@@H](CC1)C(O)=O InChI=1S/C30H30F7NO6S/c1-17-2-6-21(7-3-17)45(43,44)27-14-15-38(25(41)26(42)12-10-18(11-13-26)24(39)40)23(27)9-4-19-16-20(5-8-22(19)27)28(31,29(32,33)34)30(35,36)37/h2-3,5-8,16,18,23,42H,4,9-15H2,1H3,(H,39,40)/t18-,23?,26+,27? HZUVIRMBMVZZEX-MJALUPOVSA-N 382431 US10273259, Example 142::US10711020, Example 142 Nuclear receptor ROR-gamma [262-507] 50.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382431 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382431&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 145183933 404851800 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931055 OC(=O)C12CCC(CC1)(CC2)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(cc1)C1CC1 InChI=1S/C34H34F7NO5S/c35-32(33(36,37)38,34(39,40)41)23-6-9-25-22(19-23)5-10-26-31(25,48(46,47)24-7-3-21(4-8-24)20-1-2-20)17-18-42(26)27(43)29-11-14-30(15-12-29,16-13-29)28(44)45/h3-4,6-9,19-20,26H,1-2,5,10-18H2,(H,44,45) QFLXVLKKEGFFIU-UHFFFAOYSA-N 382432 US10273259, Example 143::US10711020, Example 143 Nuclear receptor ROR-gamma [262-507] 129 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382432 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382432&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679023 404851801 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931056 Cc1ccc(cc1)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)[C@H]1CC[C@@H](CC1)C(O)=O InChI=1S/C30H30F7NO5S/c1-17-2-10-22(11-3-17)44(42,43)27-14-15-38(25(39)18-4-6-19(7-5-18)26(40)41)24(27)13-8-20-16-21(9-12-23(20)27)28(31,29(32,33)34)30(35,36)37/h2-3,9-12,16,18-19,24H,4-8,13-15H2,1H3,(H,40,41)/t18-,19-,24?,27? JDFDTUYICUVLET-QXIWJBPRSA-N 382232 US10273259, Example 19::US10711020, Example 144 Nuclear receptor ROR-gamma [262-507] 66.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382232 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382232&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678564 404851605 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931057 Cc1ccc(cc1)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)[C@@]1(F)CC[C@@H](CC1)C(O)=O InChI=1S/C30H29F8NO5S/c1-17-2-6-21(7-3-17)45(43,44)27-14-15-39(25(42)26(31)12-10-18(11-13-26)24(40)41)23(27)9-4-19-16-20(5-8-22(19)27)28(32,29(33,34)35)30(36,37)38/h2-3,5-8,16,18,23H,4,9-15H2,1H3,(H,40,41)/t18-,23?,26+,27? RWJCYGUITJAVMC-MJALUPOVSA-N 382248 US10273259, Example 32::US10711020, Example 145 Nuclear receptor ROR-gamma [262-507] 74.0 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382248 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382248&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122678757 404851621 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931793 CN1[C@@H](C[C@H](O)C1=O)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(Cl)cc1 InChI=1S/C27H24ClF7N2O5S/c1-36-19(13-20(38)23(36)40)22(39)37-11-10-24(43(41,42)17-6-4-16(28)5-7-17)18-8-3-15(12-14(18)2-9-21(24)37)25(29,26(30,31)32)27(33,34)35/h3-8,12,19-21,38H,2,9-11,13H2,1H3/t19-,20-,21?,24?/m0/s1 XQJNUGSGRULWKH-SZYSUKIFSA-N 383172 US10273259, Example 883::US10711020, Example 883 Nuclear receptor ROR-gamma [262-507] 201 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383172 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383172&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 145995620 404852467 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931794 CO[C@H]1C[C@H](N(C)C1=O)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(Cl)cc1 InChI=1S/C28H26ClF7N2O5S/c1-37-20(14-21(43-2)24(37)40)23(39)38-12-11-25(44(41,42)18-7-5-17(29)6-8-18)19-9-4-16(13-15(19)3-10-22(25)38)26(30,27(31,32)33)28(34,35)36/h4-9,13,20-22H,3,10-12,14H2,1-2H3/t20-,21-,22?,25?/m0/s1 YCJWBWOKWUXKGO-GFOXRHNOSA-N 383173 US10273259, Example 884::US10711020, Example 884 Nuclear receptor ROR-gamma [262-507] 477 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383173 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383173&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 145995621 404852468 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 931795 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1CCN(CC1)C=O InChI=1S/C28H26F8N2O4S/c29-20-3-5-21(6-4-20)43(41,42)25-11-14-38(24(40)17-9-12-37(16-39)13-10-17)23(25)8-1-18-15-19(2-7-22(18)25)26(30,27(31,32)33)28(34,35)36/h2-7,15-17,23H,1,8-14H2/t23-,25-/m1/s1 JDBYOVCVWRGARG-ILBGXUMGSA-N 383174 US10273259, Example 885::US10711020, Example 885 Nuclear receptor ROR-gamma [262-507] 167 US Patent 10.7270/Q2N019JS aid1804605 US10711020 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383174 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383174&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 122679283 404852469 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068885 CC(=O)N1CCC(CC1)C(=O)N1C[C@@H](Cc2ccccc2)[C@@H](C1)c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C28H30F6N2O3/c1-18(37)35-13-11-21(12-14-35)25(38)36-16-22(15-19-5-3-2-4-6-19)24(17-36)20-7-9-23(10-8-20)26(39,27(29,30)31)28(32,33)34/h2-10,21-22,24,39H,11-17H2,1H3/t22-,24+/m1/s1 IUBJKQLAZXWECO-VWNXMTODSA-N 510696 US11078186, Example 150 Nuclear receptor ROR-gamma [262-507] 1278 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510696 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510696&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 153313937 459627965 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068886 CC(=O)N1CCN(CC1)C(=O)N1C[C@@H](Cc2ccccc2)[C@@H](C1)c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C27H29F6N3O3/c1-18(37)34-11-13-35(14-12-34)24(38)36-16-21(15-19-5-3-2-4-6-19)23(17-36)20-7-9-22(10-8-20)25(39,26(28,29)30)27(31,32)33/h2-10,21,23,39H,11-17H2,1H3/t21-,23+/m1/s1 XHMIBLVMHURELU-GGAORHGYSA-N 510697 US11078186, Example 151 Nuclear receptor ROR-gamma [262-507] 3481 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510697 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510697&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 149215836 459627966 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068887 OC(c1ccc(cc1)[C@@H]1CN(C[C@H]1Cc1ccccc1)C(=O)NCc1ccccc1)(C(F)(F)F)C(F)(F)F InChI=1S/C28H26F6N2O2/c29-27(30,31)26(38,28(32,33)34)23-13-11-21(12-14-23)24-18-36(17-22(24)15-19-7-3-1-4-8-19)25(37)35-16-20-9-5-2-6-10-20/h1-14,22,24,38H,15-18H2,(H,35,37)/t22-,24+/m1/s1 WDPYBWVXIVIUNV-VWNXMTODSA-N 510698 US11078186, Example 152 Nuclear receptor ROR-gamma [262-507] 881 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510698 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510698&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 153167910 459627967 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068888 CC(=O)N1CCC(CC1)C(=O)N1C[C@@H](Cc2ccccc2)[C@@H](C1)c1ccc(cc1)-c1c(F)cccc1F InChI=1S/C31H32F2N2O2/c1-21(36)34-16-14-25(15-17-34)31(37)35-19-26(18-22-6-3-2-4-7-22)27(20-35)23-10-12-24(13-11-23)30-28(32)8-5-9-29(30)33/h2-13,25-27H,14-20H2,1H3/t26-,27+/m1/s1 NEZGUJFZDRMDDN-SXOMAYOGSA-N 510699 US11078186, Example 153 Nuclear receptor ROR-gamma [262-507] 4940 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510699 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510699&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 148614278 459627968 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068889 CC(=O)N1CCN(CC1)C(=O)N1C[C@@H](Cc2ccccc2)[C@@H](C1)c1ccc(cc1)-c1c(F)cccc1F InChI=1S/C30H31F2N3O2/c1-21(36)33-14-16-34(17-15-33)30(37)35-19-25(18-22-6-3-2-4-7-22)26(20-35)23-10-12-24(13-11-23)29-27(31)8-5-9-28(29)32/h2-13,25-26H,14-20H2,1H3/t25-,26+/m1/s1 KYPWWBUMHYLYQH-FTJBHMTQSA-N 510700 US11078186, Example 154 Nuclear receptor ROR-gamma [262-507] 965 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510700 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510700&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 134506963 459627969 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068890 Fc1cccc(F)c1-c1ccc(cc1)[C@@H]1CN(C[C@H]1Cc1ccccc1)C(=O)Cc1ccncc1 InChI=1S/C30H26F2N2O/c31-27-7-4-8-28(32)30(27)24-11-9-23(10-12-24)26-20-34(29(35)18-22-13-15-33-16-14-22)19-25(26)17-21-5-2-1-3-6-21/h1-16,25-26H,17-20H2/t25-,26+/m1/s1 JBPUPSMXQUYJFL-FTJBHMTQSA-N 510701 US11078186, Example 155 Nuclear receptor ROR-gamma [262-507] 477 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510701 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510701&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 134506965 459627970 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068891 Fc1cccc(F)c1-c1ccc(cc1)[C@@H]1CN(C[C@H]1Cc1ccccc1)C(=O)Cc1ccc(cc1)C#N InChI=1S/C32H26F2N2O/c33-29-7-4-8-30(34)32(29)26-15-13-25(14-16-26)28-21-36(20-27(28)17-22-5-2-1-3-6-22)31(37)18-23-9-11-24(19-35)12-10-23/h1-16,27-28H,17-18,20-21H2/t27-,28+/m1/s1 HTNSMRIGUIDPMS-IZLXSDGUSA-N 510702 US11078186, Example 156 Nuclear receptor ROR-gamma [262-507] 528 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510702 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510702&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 153313914 459627971 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068892 CC(=O)N1CCC(CC1)C(=O)N1C[C@@H](Cc2cccc3CCCCc23)[C@@H](C1)c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C32H36F6N2O3/c1-20(41)39-15-13-23(14-16-39)29(42)40-18-25(17-24-7-4-6-21-5-2-3-8-27(21)24)28(19-40)22-9-11-26(12-10-22)30(43,31(33,34)35)32(36,37)38/h4,6-7,9-12,23,25,28,43H,2-3,5,8,13-19H2,1H3/t25-,28+/m1/s1 CUAXTKXOFAZHGG-NAKRPHOHSA-N 510703 US11078186, Example 157 Nuclear receptor ROR-gamma [262-507] 3026 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510703 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510703&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 147290262 459627972 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068893 OC(c1ccc(cc1)[C@@H]1CN(C[C@H]1Cc1cccc2CCCCc12)C(=O)Cc1ccc(cc1)C#N)(C(F)(F)F)C(F)(F)F InChI=1S/C33H30F6N2O2/c34-32(35,36)31(43,33(37,38)39)27-14-12-24(13-15-27)29-20-41(30(42)16-21-8-10-22(18-40)11-9-21)19-26(29)17-25-6-3-5-23-4-1-2-7-28(23)25/h3,5-6,8-15,26,29,43H,1-2,4,7,16-17,19-20H2/t26-,29+/m1/s1 HNXCDCZHHZHMPT-UHSQPCAPSA-N 510704 US11078186, Example 158 Nuclear receptor ROR-gamma [262-507] 1997 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510704 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510704&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 147813838 459627973 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068894 OC(c1ccc(cc1)[C@@H]1CN(C[C@H]1Cc1cccc2CCCCc12)C(=O)Cc1ccncc1)(C(F)(F)F)C(F)(F)F InChI=1S/C31H30F6N2O2/c32-30(33,34)29(41,31(35,36)37)25-10-8-22(9-11-25)27-19-39(28(40)16-20-12-14-38-15-13-20)18-24(27)17-23-6-3-5-21-4-1-2-7-26(21)23/h3,5-6,8-15,24,27,41H,1-2,4,7,16-19H2/t24-,27+/m1/s1 SXPFWEJLDKTCHC-SQHAQQRYSA-N 510705 US11078186, Example 159 Nuclear receptor ROR-gamma [262-507] 2620 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510705 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510705&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 153313955 459627974 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068895 OC(c1ccc(cc1)[C@@H]1CN(C[C@H]1Cc1cccc2CCCCc12)C(=O)NCc1ccccc1)(C(F)(F)F)C(F)(F)F InChI=1S/C32H32F6N2O2/c33-31(34,35)30(42,32(36,37)38)26-15-13-23(14-16-26)28-20-40(29(41)39-18-21-7-2-1-3-8-21)19-25(28)17-24-11-6-10-22-9-4-5-12-27(22)24/h1-3,6-8,10-11,13-16,25,28,42H,4-5,9,12,17-20H2,(H,39,41)/t25-,28+/m1/s1 TVRIWLUFEHEKBS-NAKRPHOHSA-N 510706 US11078186, Example 160 Nuclear receptor ROR-gamma [262-507] 538 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510706 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510706&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 152852649 459627975 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068896 CC(=O)N1CCC(CC1)C(=O)N1C[C@@H](Cc2cccc3ccccc23)[C@@H](C1)c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C32H32F6N2O3/c1-20(41)39-15-13-23(14-16-39)29(42)40-18-25(17-24-7-4-6-21-5-2-3-8-27(21)24)28(19-40)22-9-11-26(12-10-22)30(43,31(33,34)35)32(36,37)38/h2-12,23,25,28,43H,13-19H2,1H3/t25-,28+/m1/s1 ZOHIJYPNVYJULT-NAKRPHOHSA-N 510707 US11078186, Example 161 Nuclear receptor ROR-gamma [262-507] 485 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510707 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510707&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 134506917 459627976 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068897 OC(c1ccc(cc1)[C@@H]1CN(C[C@H]1Cc1cccc2ccccc12)C(=O)Cc1ccncc1)(C(F)(F)F)C(F)(F)F InChI=1S/C31H26F6N2O2/c32-30(33,34)29(41,31(35,36)37)25-10-8-22(9-11-25)27-19-39(28(40)16-20-12-14-38-15-13-20)18-24(27)17-23-6-3-5-21-4-1-2-7-26(21)23/h1-15,24,27,41H,16-19H2/t24-,27+/m1/s1 UTWTWPCSDNIGCP-SQHAQQRYSA-N 510708 US11078186, Example 162 Nuclear receptor ROR-gamma [262-507] 686 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510708 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510708&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 153313911 459627977 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068898 OC(c1ccc(cc1)[C@@H]1CN(C[C@H]1Cc1cccc2ccccc12)C(=O)NCc1ccccc1)(C(F)(F)F)C(F)(F)F InChI=1S/C32H28F6N2O2/c33-31(34,35)30(42,32(36,37)38)26-15-13-23(14-16-26)28-20-40(29(41)39-18-21-7-2-1-3-8-21)19-25(28)17-24-11-6-10-22-9-4-5-12-27(22)24/h1-16,25,28,42H,17-20H2,(H,39,41)/t25-,28+/m1/s1 WLRRMLKHPJFZRI-NAKRPHOHSA-N 510709 US11078186, Example 163 Nuclear receptor ROR-gamma [262-507] 1481 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510709 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510709&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 153210489 459627978 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068899 CC(=O)N1CCN(CC1)C(=O)N1C[C@@H](Cc2cccc3ccccc23)[C@@H](C1)c1ccc(cc1)-c1c(F)cccc1F InChI=1S/C34H33F2N3O2/c1-23(40)37-16-18-38(19-17-37)34(41)39-21-28(20-27-8-4-7-24-6-2-3-9-29(24)27)30(22-39)25-12-14-26(15-13-25)33-31(35)10-5-11-32(33)36/h2-15,28,30H,16-22H2,1H3/t28-,30+/m1/s1 RDDNXQABWWAZLX-DGPALRBDSA-N 510710 US11078186, Example 164::US11078186, Example 165 Nuclear receptor ROR-gamma [262-507] 3348 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510710 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510710&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 149133011 459627979 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068900 CC(=O)N1CCN(CC1)C(=O)N1C[C@@H](Cc2cccc3ccccc23)[C@@H](C1)c1ccc(cc1)-c1c(F)cccc1F InChI=1S/C34H33F2N3O2/c1-23(40)37-16-18-38(19-17-37)34(41)39-21-28(20-27-8-4-7-24-6-2-3-9-29(24)27)30(22-39)25-12-14-26(15-13-25)33-31(35)10-5-11-32(33)36/h2-15,28,30H,16-22H2,1H3/t28-,30+/m1/s1 RDDNXQABWWAZLX-DGPALRBDSA-N 510710 US11078186, Example 164::US11078186, Example 165 Nuclear receptor ROR-gamma [262-507] 2339 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510710 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510710&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 149133011 459627979 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068901 Fc1cccc(F)c1-c1ccc(cc1)[C@@H]1CN(C[C@H]1Cc1cccc2ccccc12)C(=O)Cc1ccncc1 InChI=1S/C34H28F2N2O/c35-31-9-4-10-32(36)34(31)26-13-11-25(12-14-26)30-22-38(33(39)19-23-15-17-37-18-16-23)21-28(30)20-27-7-3-6-24-5-1-2-8-29(24)27/h1-18,28,30H,19-22H2/t28-,30+/m1/s1 CPFNXROCEPDYOV-DGPALRBDSA-N 510712 US11078186, Example 166 Nuclear receptor ROR-gamma [262-507] 1880 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510712 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510712&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 153313929 459627980 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068902 C[C@@]1(CN(C[C@H]1c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F)C(=O)Cc1ccc(cc1)C(N)=O)c1ccc(F)cc1 InChI=1S/C29H25F7N2O3/c1-26(20-10-12-22(30)13-11-20)16-38(24(39)14-17-2-4-19(5-3-17)25(37)40)15-23(26)18-6-8-21(9-7-18)27(41,28(31,32)33)29(34,35)36/h2-13,23,41H,14-16H2,1H3,(H2,37,40)/t23-,26+/m0/s1 ROHHNXAUNKHIFB-JYFHCDHNSA-N 510713 4-(2-((3S,4S)-3-(4-fluorophenyl)-4-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl)-3-methylpyrrolidin-1-yl)-2-oxoethyl)benzamide::US11078186, Example 167 Nuclear receptor ROR-gamma [262-507] 51.0 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510713 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510713&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 142754756 459627981 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068903 CC(=O)N1CCN(CC1)C(=O)N1C[C@H]([C@@H](C1)S(=O)(=O)c1ccc(F)c(Br)c1)c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F InChI=1S/C33H29BrF9N3O5S/c1-19(47)44-11-13-45(14-12-44)30(48)46-16-23(29(17-46)52(49,50)22-9-10-28(37)25(34)15-22)20-5-7-21(8-6-20)31(32(38,39)40,33(41,42)43)51-18-24-26(35)3-2-4-27(24)36/h2-10,15,23,29H,11-14,16-18H2,1H3/t23-,29+/m0/s1 QLCHXHFFVBNWKF-MUAVYFROSA-N 510714 1-(4-((3 S4R)-3-((3-bromo-4-fluorophenyl)sulfonyl)-4-(4-(2-((2,6-difluorobenzyl)oxy)-1,1,1,3,3,3-hexafluoropropan-2-yl)phenyl)pyrrolidine-1-carbonyl)piperazin-1-yl)ethanone & 1-(4-((3R,4S)-3-((3-bromo-4-fluorophenyl)sulfonyl)-4-(4-(2-((2,6-difluorobenzyl)oxy)-1,1,1,3,3,3-hexafluoropropan-2-yl)phenyl)pyrrolidine-1-carbonyl)piperazin-1-yl)ethanone::US11078186, Example 168::US11078186, Example 169 Nuclear receptor ROR-gamma [262-507] 326 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510714 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510714&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 134499161 459627982 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068904 CC(=O)N1CCN(CC1)C(=O)N1C[C@H]([C@@H](C1)S(=O)(=O)c1ccc(F)c(Br)c1)c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F InChI=1S/C33H29BrF9N3O5S/c1-19(47)44-11-13-45(14-12-44)30(48)46-16-23(29(17-46)52(49,50)22-9-10-28(37)25(34)15-22)20-5-7-21(8-6-20)31(32(38,39)40,33(41,42)43)51-18-24-26(35)3-2-4-27(24)36/h2-10,15,23,29H,11-14,16-18H2,1H3/t23-,29+/m0/s1 QLCHXHFFVBNWKF-MUAVYFROSA-N 510714 1-(4-((3 S4R)-3-((3-bromo-4-fluorophenyl)sulfonyl)-4-(4-(2-((2,6-difluorobenzyl)oxy)-1,1,1,3,3,3-hexafluoropropan-2-yl)phenyl)pyrrolidine-1-carbonyl)piperazin-1-yl)ethanone & 1-(4-((3R,4S)-3-((3-bromo-4-fluorophenyl)sulfonyl)-4-(4-(2-((2,6-difluorobenzyl)oxy)-1,1,1,3,3,3-hexafluoropropan-2-yl)phenyl)pyrrolidine-1-carbonyl)piperazin-1-yl)ethanone::US11078186, Example 168::US11078186, Example 169 Nuclear receptor ROR-gamma [262-507] 1012 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510714 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510714&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 134499161 459627982 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068905 CC(=O)N1CCN(CC1)C(=O)N1C[C@@H]([C@H](C1)S(=O)(=O)c1ccc(F)cc1)c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F InChI=1S/C33H30F9N3O5S/c1-20(46)43-13-15-44(16-14-43)30(47)45-17-25(29(18-45)51(48,49)24-11-9-23(34)10-12-24)21-5-7-22(8-6-21)31(32(37,38)39,33(40,41)42)50-19-26-27(35)3-2-4-28(26)36/h2-12,25,29H,13-19H2,1H3/t25-,29+/m1/s1 AXGHAAZWFLDYQY-IRPSRAIASA-N 510716 1-(4-((3S,4R)-3-(4-(2-((2,6-difluorobenzyl)oxy)-1,1,1,3,3,3-hexafluoropropan-2-yl)phenyl)-4-((4-fluorophenyl)sulfonyl)pyrrolidine-1-carbonyl)piperazin-1-yl)ethanone::US11078186, Example 170 Nuclear receptor ROR-gamma [262-507] 593 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510716 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510716&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 134506975 459627983 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068906 CC(=O)N1CCN(CC1)C(=O)N1C[C@H]([C@@H](C1)S(=O)(=O)c1ccc(F)cc1)c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F InChI=1S/C33H30F9N3O5S/c1-20(46)43-13-15-44(16-14-43)30(47)45-17-25(29(18-45)51(48,49)24-11-9-23(34)10-12-24)21-5-7-22(8-6-21)31(32(37,38)39,33(40,41)42)50-19-26-27(35)3-2-4-28(26)36/h2-12,25,29H,13-19H2,1H3/t25-,29+/m0/s1 AXGHAAZWFLDYQY-ABYGYWHVSA-N 510717 1-(4-((3R,4S)-3-(4-(2-((2,6-difluorobenzyl)oxy)-1,1,1,3,3,3-hexafluoropropan-2-yl)phenyl)-4-((4-fluorophenyl)sulfonyl)pyrrolidine-1-carbonyl)piperazin-1-yl)ethanone::US11078186, Example 171 Nuclear receptor ROR-gamma [262-507] 190 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510717 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510717&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 134507131 459627984 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068907 CC(=O)N1CCN(CC1)C(=O)N1C[C@H]([C@@H](C1)S(=O)(=O)c1ccc(F)c(C=C)c1)c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F InChI=1S/C35H32F9N3O5S/c1-3-22-17-25(11-12-28(22)36)53(50,51)31-19-47(32(49)46-15-13-45(14-16-46)21(2)48)18-26(31)23-7-9-24(10-8-23)33(34(39,40)41,35(42,43)44)52-20-27-29(37)5-4-6-30(27)38/h3-12,17,26,31H,1,13-16,18-20H2,2H3/t26-,31+/m0/s1 BTSSMJFGUIHHHF-SUYBVONHSA-N 510718 1-(4-((3R,4S)-3-(4-(2-((2,6-difluorobenzyl)oxy)-1,1,1,1,3,3,3-hexafluoropropan-2-yl)phenyl)-4-((4-fluoro-3-vinylphenyl)sulfonyl)pyrrolidine-1-carbonyl)piperazin-1-yl)ethanone::US11078186, Example 172 Nuclear receptor ROR-gamma [262-507] 517 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510718 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510718&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 134506937 459627985 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068908 CC(=O)N1CCN(CC1)C(=O)N1C[C@H]([C@@H](C1)S(=O)(=O)c1ccc(F)c(CC=C)c1)c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F InChI=1S/C36H34F9N3O5S/c1-3-5-24-18-26(12-13-29(24)37)54(51,52)32-20-48(33(50)47-16-14-46(15-17-47)22(2)49)19-27(32)23-8-10-25(11-9-23)34(35(40,41)42,36(43,44)45)53-21-28-30(38)6-4-7-31(28)39/h3-4,6-13,18,27,32H,1,5,14-17,19-21H2,2H3/t27-,32+/m0/s1 GKNFSBYIFMVEQR-QVWWMRLHSA-N 510719 1-(4-((3S,4R)-3-((3-allyl-4-fluorophenyl)sulfonyl)-4-(4-(2-((2,6-difluorobenzyl)oxy)-1,1,1,3,3,3-hexafluoropropan-2-yl)phenyl)pyrrolidine-1-carbonyl)piperazin-1-yl)ethanone::US11078186, Example 173 Nuclear receptor ROR-gamma [262-507] 89.0 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510719 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510719&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 134506924 459627986 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068909 CC(=O)N1CCN(CC1)C(=O)N1C[C@H]([C@@H](C1)S(=O)(=O)c1ccc(F)c(c1)C1CC1)c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F InChI=1S/C36H34F9N3O5S/c1-21(49)46-13-15-47(16-14-46)33(50)48-18-27(32(19-48)54(51,52)25-11-12-31(39)26(17-25)22-5-6-22)23-7-9-24(10-8-23)34(35(40,41)42,36(43,44)45)53-20-28-29(37)3-2-4-30(28)38/h2-4,7-12,17,22,27,32H,5-6,13-16,18-20H2,1H3/t27-,32+/m0/s1 SEPUSTOWQJQTLO-QVWWMRLHSA-N 510720 1-(4-((3S,4R)-3-((3-cyclopropyl-4-fluorophenyl)sulfonyl)-4-(4-(2-((2,6-difluorobenzyl)oxy)-1,1,1,3,3,3-hexafluoropropan-2-yl)phenyl)pyrrolidine-1-carbonyl)piperazin-1-yl)ethanone::US11078186, Example 174 Nuclear receptor ROR-gamma [262-507] 79.0 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510720 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510720&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 134501219 459627987 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068910 CC(=O)N1CCN(CC1)C(=O)N1C[C@H]([C@@H](C1)S(=O)(=O)c1ccc(F)c(c1)-c1ccccc1)c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F InChI=1S/C39H34F9N3O5S/c1-24(52)49-16-18-50(19-17-49)36(53)51-21-30(35(22-51)57(54,55)28-14-15-34(42)29(20-28)25-6-3-2-4-7-25)26-10-12-27(13-11-26)37(38(43,44)45,39(46,47)48)56-23-31-32(40)8-5-9-33(31)41/h2-15,20,30,35H,16-19,21-23H2,1H3/t30-,35+/m0/s1 JMJNLOQXWFXKDO-LWQYYNMXSA-N 510721 1-(4-((3R,4S)-3-(4-(2-((2,6-difluorobenzyl)oxy)-1,1,1,3,3,3-hexafluoropropan-2-yl)phenyl)-4-((6-fluoro-[1,1'-biphenyl]-3-yl)sulfonyl)pyrrolidine-1-carbonyl)piperazin-1-yl)ethanone::US11078186, Example 175 Nuclear receptor ROR-gamma [262-507] 606 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510721 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510721&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 134506929 459627988 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068911 CC(=O)N1CCN(CC1)C(=O)N1C[C@@H]([C@H](C1)S(=O)(=O)c1ccc(F)c(c1)-c1ccccc1)c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F InChI=1S/C39H34F9N3O5S/c1-24(52)49-16-18-50(19-17-49)36(53)51-21-30(35(22-51)57(54,55)28-14-15-34(42)29(20-28)25-6-3-2-4-7-25)26-10-12-27(13-11-26)37(38(43,44)45,39(46,47)48)56-23-31-32(40)8-5-9-33(31)41/h2-15,20,30,35H,16-19,21-23H2,1H3/t30-,35+/m1/s1 JMJNLOQXWFXKDO-BIMVPBQRSA-N 510722 1-(4-((3S,4R)-3-(4-(2-((2,6-difluorobenzyl)oxy)-1,1,1,3,3,3-hexafluoropropan-2-yl)phenyl)-4-((6-fluoro-[1,1'-biphenyl]-3-yl)sulfonyl)pyrrolidine-1-carbonyl)piperazin-1-yl)ethanone::US11078186, Example 176 Nuclear receptor ROR-gamma [262-507] 84.0 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510722 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510722&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 142754768 459627989 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068912 CC(=O)N1CCN(CC1)C(=O)N1C[C@H]([C@@H](C1)S(=O)(=O)c1ccc(F)c(c1)-c1cnn(C)c1)c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F InChI=1S/C37H34F9N5O5S/c1-22(52)49-12-14-50(15-13-49)34(53)51-19-28(33(20-51)57(54,55)26-10-11-32(40)27(16-26)24-17-47-48(2)18-24)23-6-8-25(9-7-23)35(36(41,42)43,37(44,45)46)56-21-29-30(38)4-3-5-31(29)39/h3-11,16-18,28,33H,12-15,19-21H2,1-2H3/t28-,33+/m0/s1 UECPXIHYSVTRMG-QPQHGXMVSA-N 510723 1-(4-((3R,4S)-3-(4-(2-((2,6-difluorobenzyl)oxy)-1,1,1,3,3,3-hexafluoropropan-2-yl)phenyl)-4-((4-fluoro-3-(1-methyl-1H-pyrazol-4-yl)phenyl)sulfonyl)pyrrolidine-1-carbonyl)piperazin-1-yl)ethanone::US11078186, Example 177 Nuclear receptor ROR-gamma [262-507] 542 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510723 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510723&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 134506935 459627990 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068736 CC(C)(C)OC(=O)N1C[C@@H](c2ccc(Br)cc2)[C@](C)(C1)c1ccccc1 InChI=1S/C22H26BrNO2/c1-21(2,3)26-20(25)24-14-19(16-10-12-18(23)13-11-16)22(4,15-24)17-8-6-5-7-9-17/h5-13,19H,14-15H2,1-4H3/t19-,22+/m0/s1 AFQFDCLLKUYMPY-SIKLNZKXSA-N 510547 US11078186, Example 1::US11078186, Example 2::US11078186, Example 3::rac-(3S,4S)-tert-butyl 4-(4-bromophenyl)-3-methyl-3-phenylpyrrolidine-1-carboxylate Nuclear receptor ROR-gamma [262-507] 272 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510547 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510547&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 134498612 459627836 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068737 CC(C)(C)OC(=O)N1C[C@@H](c2ccc(Br)cc2)[C@](C)(C1)c1ccccc1 InChI=1S/C22H26BrNO2/c1-21(2,3)26-20(25)24-14-19(16-10-12-18(23)13-11-16)22(4,15-24)17-8-6-5-7-9-17/h5-13,19H,14-15H2,1-4H3/t19-,22+/m0/s1 AFQFDCLLKUYMPY-SIKLNZKXSA-N 510547 US11078186, Example 1::US11078186, Example 2::US11078186, Example 3::rac-(3S,4S)-tert-butyl 4-(4-bromophenyl)-3-methyl-3-phenylpyrrolidine-1-carboxylate Nuclear receptor ROR-gamma [262-507] 627 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510547 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510547&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 134498612 459627836 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068738 CC(C)(C)OC(=O)N1C[C@@H](c2ccc(Br)cc2)[C@](C)(C1)c1ccccc1 InChI=1S/C22H26BrNO2/c1-21(2,3)26-20(25)24-14-19(16-10-12-18(23)13-11-16)22(4,15-24)17-8-6-5-7-9-17/h5-13,19H,14-15H2,1-4H3/t19-,22+/m0/s1 AFQFDCLLKUYMPY-SIKLNZKXSA-N 510547 US11078186, Example 1::US11078186, Example 2::US11078186, Example 3::rac-(3S,4S)-tert-butyl 4-(4-bromophenyl)-3-methyl-3-phenylpyrrolidine-1-carboxylate Nuclear receptor ROR-gamma [262-507] 1053 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510547 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510547&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 134498612 459627836 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068739 CC(C)(C)OC(=O)N1C[C@H](c2ccccc2)[C@@](C)(C1)c1ccc(Br)cc1 InChI=1S/C22H26BrNO2/c1-21(2,3)26-20(25)24-14-19(16-8-6-5-7-9-16)22(4,15-24)17-10-12-18(23)13-11-17/h5-13,19H,14-15H2,1-4H3/t19-,22+/m1/s1 SMIULQATDCXCMO-KNQAVFIVSA-N 510550 US11078186, Example 4::rac-(3R,4R)-tert-butyl 3-(4-bromophenyl)-3-methyl-4-phenylpyrrolidine-1-carboxylate Nuclear receptor ROR-gamma [262-507] 644 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510550 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510550&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 134498594 459627837 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068740 CC(C)(C)OC(=O)N1C[C@@H](c2ccc(cc2)C(O)(C(F)(F)F)C(F)(F)F)[C@](C)(C1)c1ccc(F)cc1 InChI=1S/C25H26F7NO3/c1-21(2,3)36-20(34)33-13-19(22(4,14-33)16-9-11-18(26)12-10-16)15-5-7-17(8-6-15)23(35,24(27,28)29)25(30,31)32/h5-12,19,35H,13-14H2,1-4H3/t19-,22+/m0/s1 NGYTWHUHSJFZCY-SIKLNZKXSA-N 510551 US11078186, Example 5::rac-(3S,4S)-tert-butyl 3-(4-fluorophenyl)-4-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl)-3-methylpyrrolidine-1-carboxylate Nuclear receptor ROR-gamma [262-507] 111 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510551 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510551&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 134499220 459627838 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068741 CC(C)(C)OC(=O)N1C[C@H](c2ccc(cc2)C(O)(C(F)(F)F)C(F)(F)F)[C@@](C)(C1)c1ccc(F)cc1 InChI=1S/C25H26F7NO3/c1-21(2,3)36-20(34)33-13-19(22(4,14-33)16-9-11-18(26)12-10-16)15-5-7-17(8-6-15)23(35,24(27,28)29)25(30,31)32/h5-12,19,35H,13-14H2,1-4H3/t19-,22+/m1/s1 NGYTWHUHSJFZCY-KNQAVFIVSA-N 510552 (3S,4S)-tert-butyl 3-(4-fluorophenyl)-4-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl)-3-methylpyrrolidine-1-carboxylate and (3R,4R)-tert-butyl 3-(4-fluorophenyl)-4-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl)-3-methylpyrrolidine-1-carboxylate::US11078186, Example 6::US11078186, Example 7 Nuclear receptor ROR-gamma [262-507] 194 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510552 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510552&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 142754764 459627839 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068742 CC(C)(C)OC(=O)N1C[C@H](c2ccc(cc2)C(O)(C(F)(F)F)C(F)(F)F)[C@@](C)(C1)c1ccc(F)cc1 InChI=1S/C25H26F7NO3/c1-21(2,3)36-20(34)33-13-19(22(4,14-33)16-9-11-18(26)12-10-16)15-5-7-17(8-6-15)23(35,24(27,28)29)25(30,31)32/h5-12,19,35H,13-14H2,1-4H3/t19-,22+/m1/s1 NGYTWHUHSJFZCY-KNQAVFIVSA-N 510552 (3S,4S)-tert-butyl 3-(4-fluorophenyl)-4-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl)-3-methylpyrrolidine-1-carboxylate and (3R,4R)-tert-butyl 3-(4-fluorophenyl)-4-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl)-3-methylpyrrolidine-1-carboxylate::US11078186, Example 6::US11078186, Example 7 Nuclear receptor ROR-gamma [262-507] 209 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510552 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510552&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 142754764 459627839 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068743 CC(C)(C)OC(=O)N1C[C@H]([C@@H](C1)c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F)c1ccccc1 InChI=1S/C24H25F6NO3/c1-21(2,3)34-20(32)31-13-18(15-7-5-4-6-8-15)19(14-31)16-9-11-17(12-10-16)22(33,23(25,26)27)24(28,29)30/h4-12,18-19,33H,13-14H2,1-3H3/t18-,19-/m0/s1 XSUUHMZKQJKLGH-OALUTQOASA-N 510554 US11078186, Example 8 Nuclear receptor ROR-gamma [262-507] 464 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510554 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510554&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 134506969 459627840 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068744 CC[C@@]1(CN(C[C@H]1c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F)C(=O)OC(C)(C)C)c1ccccc1 InChI=1S/C26H29F6NO3/c1-5-23(18-9-7-6-8-10-18)16-33(21(34)36-22(2,3)4)15-20(23)17-11-13-19(14-12-17)24(35,25(27,28)29)26(30,31)32/h6-14,20,35H,5,15-16H2,1-4H3/t20-,23+/m0/s1 YMHSHFHWZNYMCI-NZQKXSOJSA-N 510555 US11078186, Example 9 Nuclear receptor ROR-gamma [262-507] 443 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510555 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510555&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 134506972 459627841 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068745 CC(C)(C)OC(=O)N1C[C@@H](c2ccc(cc2)C(O)(C(F)(F)F)C(F)(F)F)[C@](C)(C1)c1ccccc1 InChI=1S/C25H27F6NO3/c1-21(2,3)35-20(33)32-14-19(22(4,15-32)17-8-6-5-7-9-17)16-10-12-18(13-11-16)23(34,24(26,27)28)25(29,30)31/h5-13,19,34H,14-15H2,1-4H3/t19-,22+/m0/s1 YVWVAXBJCPBFBV-SIKLNZKXSA-N 510556 US11078186, Example 10::US11078186, Example 13 Nuclear receptor ROR-gamma [262-507] 284 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510556 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510556&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 134506858 459627842 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068746 CC(C)(C)OC(=O)N1C[C@H](c2ccccc2)[C@@](C)(C1)c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C25H27F6NO3/c1-21(2,3)35-20(33)32-14-19(16-8-6-5-7-9-16)22(4,15-32)17-10-12-18(13-11-17)23(34,24(26,27)28)25(29,30)31/h5-13,19,34H,14-15H2,1-4H3/t19-,22+/m1/s1 IDVROFREZSVIAN-KNQAVFIVSA-N 510557 US11078186, Example 11 Nuclear receptor ROR-gamma [262-507] 1086 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510557 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510557&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 134506973 459627843 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068747 CC(C)(C)OC(=O)N1C[C@H](c2ccc(cc2)C(O)(C(F)(F)F)C(F)(F)F)[C@@](C)(C1)c1ccccc1 InChI=1S/C25H27F6NO3/c1-21(2,3)35-20(33)32-14-19(22(4,15-32)17-8-6-5-7-9-17)16-10-12-18(13-11-16)23(34,24(26,27)28)25(29,30)31/h5-13,19,34H,14-15H2,1-4H3/t19-,22+/m1/s1 YVWVAXBJCPBFBV-KNQAVFIVSA-N 510558 US11078186, Example 12 Nuclear receptor ROR-gamma [262-507] 181 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510558 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510558&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 134506855 459627844 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068748 CC(C)(C)OC(=O)N1C[C@@H](c2ccc(cc2)C(O)(C(F)(F)F)C(F)(F)F)[C@](C)(C1)c1ccccc1 InChI=1S/C25H27F6NO3/c1-21(2,3)35-20(33)32-14-19(22(4,15-32)17-8-6-5-7-9-17)16-10-12-18(13-11-16)23(34,24(26,27)28)25(29,30)31/h5-13,19,34H,14-15H2,1-4H3/t19-,22+/m0/s1 YVWVAXBJCPBFBV-SIKLNZKXSA-N 510556 US11078186, Example 10::US11078186, Example 13 Nuclear receptor ROR-gamma [262-507] 200 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510556 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510556&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 134506858 459627842 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068749 CC(C)(C)OC(=O)N1C[C@H](c2ccc(cc2)C(C)(O)C(F)(F)F)[C@@](C)(C1)c1ccccc1 InChI=1S/C25H30F3NO3/c1-22(2,3)32-21(30)29-15-20(23(4,16-29)18-9-7-6-8-10-18)17-11-13-19(14-12-17)24(5,31)25(26,27)28/h6-14,20,31H,15-16H2,1-5H3/t20-,23+,24?/m1/s1 JNHAYUYUWIVXRP-FQCAPJHASA-N 510560 US11078186, Example 14 Nuclear receptor ROR-gamma [262-507] 200 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510560 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510560&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 134506859 459627845 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068750 CC(C)(C)OC(=O)N1C[C@@H](c2ccc(cc2)C(C)(O)C(F)(F)F)[C@](C)(C1)c1ccccc1 InChI=1S/C25H30F3NO3/c1-22(2,3)32-21(30)29-15-20(23(4,16-29)18-9-7-6-8-10-18)17-11-13-19(14-12-17)24(5,31)25(26,27)28/h6-14,20,31H,15-16H2,1-5H3/t20-,23+,24?/m0/s1 JNHAYUYUWIVXRP-NKCAITPYSA-N 510561 US11078186, Example 15 Nuclear receptor ROR-gamma [262-507] 3325 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510561 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510561&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 134506857 459627846 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068751 CCC(O)(c1ccc(cc1)[C@H]1CN(C[C@@]1(C)c1ccccc1)C(=O)OC(C)(C)C)C(F)(F)F InChI=1S/C26H32F3NO3/c1-6-25(32,26(27,28)29)20-14-12-18(13-15-20)21-16-30(22(31)33-23(2,3)4)17-24(21,5)19-10-8-7-9-11-19/h7-15,21,32H,6,16-17H2,1-5H3/t21-,24+,25?/m1/s1 ALJHPAHTAPDVJX-DJJHXFJNSA-N 510562 US11078186, Example 16 Nuclear receptor ROR-gamma [262-507] 86.0 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510562 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510562&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 146965259 459627847 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068752 CCC(O)(c1ccc(cc1)[C@@H]1CN(C[C@]1(C)c1ccccc1)C(=O)OC(C)(C)C)C(F)(F)F InChI=1S/C26H32F3NO3/c1-6-25(32,26(27,28)29)20-14-12-18(13-15-20)21-16-30(22(31)33-23(2,3)4)17-24(21,5)19-10-8-7-9-11-19/h7-15,21,32H,6,16-17H2,1-5H3/t21-,24+,25?/m0/s1 ALJHPAHTAPDVJX-NFJZVGLOSA-N 510563 US11078186, Example 17 Nuclear receptor ROR-gamma [262-507] 292 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510563 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510563&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 134506856 459627848 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068753 Brc1ccc(cc1)[C@@H]1CN(Cc2ccccc2)C[C@H]1C(=O)c1ccccc1 InChI=1S/C24H22BrNO/c25-21-13-11-19(12-14-21)22-16-26(15-18-7-3-1-4-8-18)17-23(22)24(27)20-9-5-2-6-10-20/h1-14,22-23H,15-17H2/t22-,23+/m0/s1 FZMINPYHABBZFO-XZOQPEGZSA-N 510564 US11078186, Example 18::rac-((3S,4R)-1-benzyl-4-(4-bromophenyl)pyrrolidin-3-yl)(phenyl)methanone Nuclear receptor ROR-gamma [262-507] 480 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510564 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510564&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 134498597 459627849 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068754 OC([C@@H]1CN(Cc2ccccc2)C[C@H]1c1ccc(Br)cc1)c1ccccc1 InChI=1S/C24H24BrNO/c25-21-13-11-19(12-14-21)22-16-26(15-18-7-3-1-4-8-18)17-23(22)24(27)20-9-5-2-6-10-20/h1-14,22-24,27H,15-17H2/t22-,23+,24?/m0/s1 ABYBUZFCSOEPHC-XAGPSQNTSA-N 510565 Diastereomers 1 and 2 of (S)-((3S,4R)-1-benzyl-4-(4-bromophenyl)pyrrolidin-3-yl)(phenyl)methanol::US11078186, Example 19::US11078186, Example 20 Nuclear receptor ROR-gamma [262-507] 4251 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510565 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510565&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 153313899 459627850 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068755 OC([C@@H]1CN(Cc2ccccc2)C[C@H]1c1ccc(Br)cc1)c1ccccc1 InChI=1S/C24H24BrNO/c25-21-13-11-19(12-14-21)22-16-26(15-18-7-3-1-4-8-18)17-23(22)24(27)20-9-5-2-6-10-20/h1-14,22-24,27H,15-17H2/t22-,23+,24?/m0/s1 ABYBUZFCSOEPHC-XAGPSQNTSA-N 510565 Diastereomers 1 and 2 of (S)-((3S,4R)-1-benzyl-4-(4-bromophenyl)pyrrolidin-3-yl)(phenyl)methanol::US11078186, Example 19::US11078186, Example 20 Nuclear receptor ROR-gamma [262-507] 4960 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510565 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510565&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 153313899 459627850 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068756 Brc1ccc(cc1)[C@@H]1CN(Cc2ccccc2)C[C@H]1Cc1ccccc1 InChI=1S/C24H24BrN/c25-23-13-11-21(12-14-23)24-18-26(16-20-9-5-2-6-10-20)17-22(24)15-19-7-3-1-4-8-19/h1-14,22,24H,15-18H2/t22-,24+/m1/s1 AEBDCWGNSFVOFE-VWNXMTODSA-N 510567 US11078186, Example 21::rac-(3S,4R)-1,3-dibenzyl-4-(4-bromophenyl)pyrrolidine Nuclear receptor ROR-gamma [262-507] 2793 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510567 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510567&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 134499174 459627851 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068757 C[C@@]1(CC(=O)C[C@H]1c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F)c1ccc(F)cc1 InChI=1S/C21H17F7O2/c1-18(13-6-8-15(22)9-7-13)11-16(29)10-17(18)12-2-4-14(5-3-12)19(30,20(23,24)25)21(26,27)28/h2-9,17,30H,10-11H2,1H3/t17-,18+/m0/s1 SMLFETAQOBRHPY-ZWKOTPCHSA-N 510568 US11078186, Example 22::rac-(3S,4S)-3-(4-fluorophenyl)-4-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl)-3-methylcyclopentanone Nuclear receptor ROR-gamma [262-507] 179 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510568 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510568&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 134499172 459627852 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068758 CC(=O)N1CCC(CC1)C(=O)N1C[C@@H](c2ccc(cc2)C(O)(C(F)(F)F)C(F)(F)F)[C@](CO)(C1)c1ccc(F)cc1 InChI=1S/C28H29F7N2O4/c1-17(39)36-12-10-19(11-13-36)24(40)37-14-23(25(15-37,16-38)20-6-8-22(29)9-7-20)18-2-4-21(5-3-18)26(41,27(30,31)32)28(33,34)35/h2-9,19,23,38,41H,10-16H2,1H3/t23-,25-/m0/s1 JJNAQMBQZXNSPA-ZCYQVOJMSA-N 510569 US11078186, Example 23::rac-1-(4-((3R,4S)-3-(4-fluorophenyl)-4-(4-(1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl)-3-(hydroxymethyl)pyrrolidine-1-carbonyl)piperidin-1-yl)ethanone Nuclear receptor ROR-gamma [262-507] 260 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510569 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510569&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 134498705 459627853 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068759 OC[C@@]1(CN(C[C@H]1c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F)C(=O)NCc1ccccc1)c1ccc(F)cc1 InChI=1S/C28H25F7N2O3/c29-22-12-10-20(11-13-22)25(17-38)16-37(24(39)36-14-18-4-2-1-3-5-18)15-23(25)19-6-8-21(9-7-19)26(40,27(30,31)32)28(33,34)35/h1-13,23,38,40H,14-17H2,(H,36,39)/t23-,25-/m0/s1 UFZXWMPAZINOKM-ZCYQVOJMSA-N 510570 US11078186, Example 24::rac-(3R,4S)—N-benzyl-3-(4-fluorophenyl)-4-(4-(1,1,3,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl)-3-(hydroxymethyl)pyrrolidine-1-carboxamide Nuclear receptor ROR-gamma [262-507] 172 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510570 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510570&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 134499111 459627854 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068760 CC(=O)N1CCC(CC1)C(=O)N1C[C@@H](c2ccc(cc2)C(O)(C(F)(F)F)C(F)(F)F)[C@](C)(C1)c1ccc(F)cc1 InChI=1S/C28H29F7N2O3/c1-17(38)36-13-11-19(12-14-36)24(39)37-15-23(25(2,16-37)20-7-9-22(29)10-8-20)18-3-5-21(6-4-18)26(40,27(30,31)32)28(33,34)35/h3-10,19,23,40H,11-16H2,1-2H3/t23-,25+/m0/s1 PLEBLNIHUKCNPF-UKILVPOCSA-N 510571 US11078186, Example 25::US11078186, Example 95::rac-1-(4-((3S,4S)-3-(4-fluorophenyl)-4-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl)-3-methylpyrrolidine-1-carbonyl)piperidin-1-yl)ethanone Nuclear receptor ROR-gamma [262-507] 311 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510571 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510571&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 134507077 459627855 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068761 COC(=O)N1C[C@@H](c2ccc(cc2)C(O)(C(F)(F)F)C(F)(F)F)[C@](C)(C1)c1ccccc1 InChI=1S/C22H21F6NO3/c1-19(15-6-4-3-5-7-15)13-29(18(30)32-2)12-17(19)14-8-10-16(11-9-14)20(31,21(23,24)25)22(26,27)28/h3-11,17,31H,12-13H2,1-2H3/t17-,19+/m0/s1 PULFJZBMRUJPED-PKOBYXMFSA-N 510572 (3S,4S)-methyl 4-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl)-3-methyl-3-phenylpyrrolidine-1-carboxylate::US11078186, Example 26::US11078186, Example 54 Nuclear receptor ROR-gamma [262-507] 284 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510572 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510572&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 134499099 459627856 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068762 C[C@@]1(CN(Cc2ccccc2)C[C@H]1c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F)c1ccccc1 InChI=1S/C27H25F6NO/c1-24(21-10-6-3-7-11-21)18-34(16-19-8-4-2-5-9-19)17-23(24)20-12-14-22(15-13-20)25(35,26(28,29)30)27(31,32)33/h2-15,23,35H,16-18H2,1H3/t23-,24+/m0/s1 AKLFLVCBPUPSAL-BJKOFHAPSA-N 510573 US11078186, Example 27::rac-2-(4-((3S,4S)-1-benzyl-4-methyl-4-phenylpyrrolidin-3-yl)phenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol Nuclear receptor ROR-gamma [262-507] 691 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510573 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510573&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 142754757 459627857 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068763 C[C@@]1(CN(CC(N)=O)C[C@H]1c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F)c1ccccc1 InChI=1S/C22H22F6N2O2/c1-19(15-5-3-2-4-6-15)13-30(12-18(29)31)11-17(19)14-7-9-16(10-8-14)20(32,21(23,24)25)22(26,27)28/h2-10,17,32H,11-13H2,1H3,(H2,29,31)/t17-,19+/m0/s1 NANKRNOZMVMNLJ-PKOBYXMFSA-N 510574 US11078186, Example 28::rac-2-((3S,4S)-4-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl)-3-methyl-3-phenylpyrrolidin-1-yl)acetamide Nuclear receptor ROR-gamma [262-507] 665 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510574 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510574&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 134501178 459627858 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068764 C[C@@]1(CN(C[C@H]1c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F)c1ncc(cn1)C#N)c1ccccc1 InChI=1S/C25H20F6N4O/c1-22(18-5-3-2-4-6-18)15-35(21-33-12-16(11-32)13-34-21)14-20(22)17-7-9-19(10-8-17)23(36,24(26,27)28)25(29,30)31/h2-10,12-13,20,36H,14-15H2,1H3/t20-,22+/m0/s1 VCAZGWYOAPAULB-RBBKRZOGSA-N 510575 2-((3S,4S)-4-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl)-3-methyl-3-phenylpyrrolidin-1-yl)pyrimidine-5-carbonitrile::US11078186, Example 29 Nuclear receptor ROR-gamma [262-507] 190 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510575 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510575&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 142754753 459627859 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068765 C[C@]1(CN(C[C@@H]1c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F)c1ncc(cn1)C#N)c1ccccc1 InChI=1S/C25H20F6N4O/c1-22(18-5-3-2-4-6-18)15-35(21-33-12-16(11-32)13-34-21)14-20(22)17-7-9-19(10-8-17)23(36,24(26,27)28)25(29,30)31/h2-10,12-13,20,36H,14-15H2,1H3/t20-,22+/m1/s1 VCAZGWYOAPAULB-IRLDBZIGSA-N 510576 2-((3R,4R)-4-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl)-3-methyl-3-phenylpyrrolidin-1-yl)pyrimidine-5-carbonitrile::US11078186, Example 30 Nuclear receptor ROR-gamma [262-507] 397 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510576 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510576&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 142754771 459627860 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068766 C[C@@]1(CN(C[C@H]1c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F)c1ncc(cn1)C#N)c1ccc(F)cc1 InChI=1S/C25H19F7N4O/c1-22(17-6-8-19(26)9-7-17)14-36(21-34-11-15(10-33)12-35-21)13-20(22)16-2-4-18(5-3-16)23(37,24(27,28)29)25(30,31)32/h2-9,11-12,20,37H,13-14H2,1H3/t20-,22+/m0/s1 MOFUDAJTVIAWPZ-RBBKRZOGSA-N 510577 2-((3S,4S)-3-(4-fluorophenyl)-4-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl)-3-methylpyrrolidin-1-yl)pyrimidine-5-carbonitrile::US11078186, Example 31 Nuclear receptor ROR-gamma [262-507] 72.0 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510577 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510577&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 142754754 459627861 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068767 C[C@@]1(CN(C[C@H]1c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F)C(=O)[C@@H]1CC[C@@H](CC1)C(O)=O)c1ccc(F)cc1 InChI=1S/C28H28F7NO4/c1-25(19-10-12-21(29)13-11-19)15-36(23(37)17-2-4-18(5-3-17)24(38)39)14-22(25)16-6-8-20(9-7-16)26(40,27(30,31)32)28(33,34)35/h6-13,17-18,22,40H,2-5,14-15H2,1H3,(H,38,39)/t17-,18+,22-,25+/m0/s1 ZKWKHENENAKFDH-SNMCCPJMSA-N 510578 (1R,4s)-4-((3S,4S)-3-(4-fluorophenyl)-4-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl)-3-methylpyrrolidine-1-carbonyl)cyclohexanecarboxylic acid::US11078186, Example 32 Nuclear receptor ROR-gamma [262-507] 125 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510578 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510578&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 142754766 459627862 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068768 C[C@@]1(CN(C[C@H]1c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F)C(=O)[C@H]1CC[C@@H](CC1)C(O)=O)c1ccc(F)cc1 InChI=1S/C28H28F7NO4/c1-25(19-10-12-21(29)13-11-19)15-36(23(37)17-2-4-18(5-3-17)24(38)39)14-22(25)16-6-8-20(9-7-16)26(40,27(30,31)32)28(33,34)35/h6-13,17-18,22,40H,2-5,14-15H2,1H3,(H,38,39)/t17-,18-,22-,25+/m0/s1 ZKWKHENENAKFDH-ILGRESSZSA-N 510579 (1S,4r)-4-((3S,4S)-3-(4-fluorophenyl)-4-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl)-3-methylpyrrolidine-1-carbonyl)cyclohexanecarboxylic acid::US11078186, Example 33 Nuclear receptor ROR-gamma [262-507] 1425 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510579 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510579&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 142754766 459627863 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068769 C[C@@]1(CN(C[C@H]1c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F)C(=O)C1CCN(CC1)c1ncc(cn1)C#N)c1ccc(F)cc1 InChI=1S/C31H28F7N5O2/c1-28(22-6-8-24(32)9-7-22)18-43(26(44)21-10-12-42(13-11-21)27-40-15-19(14-39)16-41-27)17-25(28)20-2-4-23(5-3-20)29(45,30(33,34)35)31(36,37)38/h2-9,15-16,21,25,45H,10-13,17-18H2,1H3/t25-,28+/m0/s1 BGDRHLQFLIVNFT-LBNVMWSVSA-N 510580 2-(4-((3S,4S)-3-(4-fluorophenyl)-4-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl)-3-methylpyrrolidine-1-carbonyl)piperidin-1-yl)pyrimidine-5-carbonitrile::US11078186, Example 34 Nuclear receptor ROR-gamma [262-507] 527 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510580 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510580&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 142754767 459627864 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068770 C[C@@]1(CN(C[C@H]1c1ccc(cc1)-c1c(F)cccc1F)C(=O)Cc1ccncc1)c1ccc(F)cc1 InChI=1S/C30H25F3N2O/c1-30(23-9-11-24(31)12-10-23)19-35(28(36)17-20-13-15-34-16-14-20)18-25(30)21-5-7-22(8-6-21)29-26(32)3-2-4-27(29)33/h2-16,25H,17-19H2,1H3/t25-,30+/m0/s1 HZUKWXSDVNZYNQ-SETSBSEESA-N 510581 US11078186, Example 35::US11078186, Example 36 Nuclear receptor ROR-gamma [262-507] 3198 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510581 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510581&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 153313932 459627865 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068771 C[C@@]1(CN(C[C@H]1c1ccc(cc1)-c1c(F)cccc1F)C(=O)Cc1ccncc1)c1ccc(F)cc1 InChI=1S/C30H25F3N2O/c1-30(23-9-11-24(31)12-10-23)19-35(28(36)17-20-13-15-34-16-14-20)18-25(30)21-5-7-22(8-6-21)29-26(32)3-2-4-27(29)33/h2-16,25H,17-19H2,1H3/t25-,30+/m0/s1 HZUKWXSDVNZYNQ-SETSBSEESA-N 510581 US11078186, Example 35::US11078186, Example 36 Nuclear receptor ROR-gamma [262-507] 199 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510581 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510581&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 153313932 459627865 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068772 CC(=O)N1CCC(CC1)C(=O)N1C[C@@H](c2ccc(cc2)-c2c(F)cccc2F)[C@](C)(C1)c1ccc(F)cc1 InChI=1S/C31H31F3N2O2/c1-20(37)35-16-14-23(15-17-35)30(38)36-18-26(31(2,19-36)24-10-12-25(32)13-11-24)21-6-8-22(9-7-21)29-27(33)4-3-5-28(29)34/h3-13,23,26H,14-19H2,1-2H3/t26-,31+/m0/s1 WDTCZUNUXXJJSI-SUYBVONHSA-N 510583 US11078186, Example 37::US11078186, Example 38 Nuclear receptor ROR-gamma [262-507] 2991 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510583 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510583&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 153313934 459627866 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068773 CC(=O)N1CCC(CC1)C(=O)N1C[C@@H](c2ccc(cc2)-c2c(F)cccc2F)[C@](C)(C1)c1ccc(F)cc1 InChI=1S/C31H31F3N2O2/c1-20(37)35-16-14-23(15-17-35)30(38)36-18-26(31(2,19-36)24-10-12-25(32)13-11-24)21-6-8-22(9-7-21)29-27(33)4-3-5-28(29)34/h3-13,23,26H,14-19H2,1-2H3/t26-,31+/m0/s1 WDTCZUNUXXJJSI-SUYBVONHSA-N 510583 US11078186, Example 37::US11078186, Example 38 Nuclear receptor ROR-gamma [262-507] 142 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510583 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510583&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 153313934 459627866 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068774 C[C@@]1(CN(C[C@H]1c1ccc(cc1)-c1c(F)cccc1F)C(=O)NCc1ccccc1)c1ccc(F)cc1 InChI=1S/C31H27F3N2O/c1-31(24-14-16-25(32)17-15-24)20-36(30(37)35-18-21-6-3-2-4-7-21)19-26(31)22-10-12-23(13-11-22)29-27(33)8-5-9-28(29)34/h2-17,26H,18-20H2,1H3,(H,35,37)/t26-,31+/m0/s1 DXSBPHKXGBSJGP-SUYBVONHSA-N 510585 US11078186, Example 39::US11078186, Example 40 Nuclear receptor ROR-gamma [262-507] 59.0 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510585 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510585&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 134506906 459627867 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068775 C[C@@]1(CN(C[C@H]1c1ccc(cc1)-c1c(F)cccc1F)C(=O)NCc1ccccc1)c1ccc(F)cc1 InChI=1S/C31H27F3N2O/c1-31(24-14-16-25(32)17-15-24)20-36(30(37)35-18-21-6-3-2-4-7-21)19-26(31)22-10-12-23(13-11-22)29-27(33)8-5-9-28(29)34/h2-17,26H,18-20H2,1H3,(H,35,37)/t26-,31+/m0/s1 DXSBPHKXGBSJGP-SUYBVONHSA-N 510585 US11078186, Example 39::US11078186, Example 40 Nuclear receptor ROR-gamma [262-507] 139 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510585 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510585&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 134506906 459627867 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068776 Cc1noc(C)c1-c1ccc(cc1)[C@@H]1CN(C[C@]1(C)c1ccc(F)cc1)C(=O)Cc1ccncc1 InChI=1S/C29H28FN3O2/c1-19-28(20(2)35-32-19)23-6-4-22(5-7-23)26-17-33(27(34)16-21-12-14-31-15-13-21)18-29(26,3)24-8-10-25(30)11-9-24/h4-15,26H,16-18H2,1-3H3/t26-,29+/m0/s1 BXBCXJVCQKIFSI-LITSAYRRSA-N 510587 US11078186, Example 41 Nuclear receptor ROR-gamma [262-507] 326 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510587 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510587&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 153313903 459627868 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068777 CC(=O)N1CCC(CC1)C(=O)N1C[C@@H](c2ccc(cc2)-c2c(C)noc2C)[C@](C)(C1)c1ccc(F)cc1 InChI=1S/C30H34FN3O3/c1-19-28(20(2)37-32-19)23-7-5-22(6-8-23)27-17-34(18-30(27,4)25-9-11-26(31)12-10-25)29(36)24-13-15-33(16-14-24)21(3)35/h5-12,24,27H,13-18H2,1-4H3/t27-,30+/m0/s1 PCQFFARPWGFOTH-BHBYDHKZSA-N 510588 US11078186, Example 42 Nuclear receptor ROR-gamma [262-507] 3829 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510588 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510588&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 153313946 459627869 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068778 Cc1noc(C)c1-c1ccc(cc1)[C@@H]1CN(C[C@]1(C)c1ccc(F)cc1)C(=O)NCc1ccccc1 InChI=1S/C30H30FN3O2/c1-20-28(21(2)36-33-20)24-11-9-23(10-12-24)27-18-34(29(35)32-17-22-7-5-4-6-8-22)19-30(27,3)25-13-15-26(31)16-14-25/h4-16,27H,17-19H2,1-3H3,(H,32,35)/t27-,30+/m0/s1 AFOVLHFLRDIJMY-BHBYDHKZSA-N 510589 US11078186, Example 43 Nuclear receptor ROR-gamma [262-507] 698 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510589 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510589&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 153313954 459627870 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068779 C[C@@]1(CN(C[C@H]1c1ccc(cc1)-c1ccccc1)C(=O)NCc1ccccc1)c1ccc(F)cc1 InChI=1S/C31H29FN2O/c1-31(27-16-18-28(32)19-17-27)22-34(30(35)33-20-23-8-4-2-5-9-23)21-29(31)26-14-12-25(13-15-26)24-10-6-3-7-11-24/h2-19,29H,20-22H2,1H3,(H,33,35)/t29-,31+/m0/s1 CKYIZIJNSUKOIM-IGYGKHONSA-N 510590 US11078186, Example 44 Nuclear receptor ROR-gamma [262-507] 3511 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510590 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510590&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 147241960 459627871 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068780 CC(=O)N1C[C@@H](c2ccc(cc2)C(O)(C(F)(F)F)C(F)(F)F)[C@](C)(C1)c1ccccc1 InChI=1S/C22H21F6NO2/c1-14(30)29-12-18(19(2,13-29)16-6-4-3-5-7-16)15-8-10-17(11-9-15)20(31,21(23,24)25)22(26,27)28/h3-11,18,31H,12-13H2,1-2H3/t18-,19+/m0/s1 AUXZEIGUWQDCNZ-RBUKOAKNSA-N 510591 US11078186, Example 45 Nuclear receptor ROR-gamma [262-507] 214 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510591 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510591&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 134506953 459627872 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068781 CCC(=O)N1C[C@@H](c2ccc(cc2)C(O)(C(F)(F)F)C(F)(F)F)[C@](C)(C1)c1ccccc1 InChI=1S/C23H23F6NO2/c1-3-19(31)30-13-18(20(2,14-30)16-7-5-4-6-8-16)15-9-11-17(12-10-15)21(32,22(24,25)26)23(27,28)29/h4-12,18,32H,3,13-14H2,1-2H3/t18-,20+/m0/s1 XTOADJRPJITLCZ-AZUAARDMSA-N 510592 US11078186, Example 46 Nuclear receptor ROR-gamma [262-507] 151 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510592 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510592&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 149284215 459627873 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068782 COCC(=O)N1C[C@@H](c2ccc(cc2)C(O)(C(F)(F)F)C(F)(F)F)[C@](C)(C1)c1ccccc1 InChI=1S/C23H23F6NO3/c1-20(16-6-4-3-5-7-16)14-30(19(31)13-33-2)12-18(20)15-8-10-17(11-9-15)21(32,22(24,25)26)23(27,28)29/h3-11,18,32H,12-14H2,1-2H3/t18-,20+/m0/s1 UVZSTIGBGVUEKX-AZUAARDMSA-N 510593 US11078186, Example 47 Nuclear receptor ROR-gamma [262-507] 112 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510593 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510593&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 153313952 459627874 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068783 CN(C)CC(=O)N1C[C@@H](c2ccc(cc2)C(O)(C(F)(F)F)C(F)(F)F)[C@](C)(C1)c1ccccc1 InChI=1S/C24H26F6N2O2/c1-21(17-7-5-4-6-8-17)15-32(20(33)14-31(2)3)13-19(21)16-9-11-18(12-10-16)22(34,23(25,26)27)24(28,29)30/h4-12,19,34H,13-15H2,1-3H3/t19-,21+/m0/s1 XGPGMLBTXWZHLZ-PZJWPPBQSA-N 510594 US11078186, Example 48 Nuclear receptor ROR-gamma [262-507] 3099 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510594 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510594&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 134506951 459627875 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068784 CC(C)C(=O)N1C[C@@H](c2ccc(cc2)C(O)(C(F)(F)F)C(F)(F)F)[C@](C)(C1)c1ccccc1 InChI=1S/C24H25F6NO2/c1-15(2)20(32)31-13-19(21(3,14-31)17-7-5-4-6-8-17)16-9-11-18(12-10-16)22(33,23(25,26)27)24(28,29)30/h4-12,15,19,33H,13-14H2,1-3H3/t19-,21+/m0/s1 UJKDWTKQPLIKDI-PZJWPPBQSA-N 510595 US11078186, Example 49 Nuclear receptor ROR-gamma [262-507] 331 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510595 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510595&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 152922678 459627876 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068785 C[C@@]1(CN(C[C@H]1c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F)C(=O)C1CC1)c1ccccc1 InChI=1S/C24H23F6NO2/c1-21(17-5-3-2-4-6-17)14-31(20(32)16-7-8-16)13-19(21)15-9-11-18(12-10-15)22(33,23(25,26)27)24(28,29)30/h2-6,9-12,16,19,33H,7-8,13-14H2,1H3/t19-,21+/m0/s1 NOPGHQNOMOVTJA-PZJWPPBQSA-N 510596 US11078186, Example 50 Nuclear receptor ROR-gamma [262-507] 175 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510596 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510596&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 153313908 459627877 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068786 CC(C)(C)C(=O)N1C[C@@H](c2ccc(cc2)C(O)(C(F)(F)F)C(F)(F)F)[C@](C)(C1)c1ccccc1 InChI=1S/C25H27F6NO2/c1-21(2,3)20(33)32-14-19(22(4,15-32)17-8-6-5-7-9-17)16-10-12-18(13-11-16)23(34,24(26,27)28)25(29,30)31/h5-13,19,34H,14-15H2,1-4H3/t19-,22+/m0/s1 LTIIJSNOORWYIA-SIKLNZKXSA-N 510597 US11078186, Example 51 Nuclear receptor ROR-gamma [262-507] 185 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510597 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510597&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 148408989 459627878 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068787 CC(=O)N1CCC(CC1)C(=O)N1C[C@@H](c2ccc(cc2)C(O)(C(F)(F)F)C(F)(F)F)[C@](C)(C1)c1ccccc1 InChI=1S/C28H30F6N2O3/c1-18(37)35-14-12-20(13-15-35)24(38)36-16-23(25(2,17-36)21-6-4-3-5-7-21)19-8-10-22(11-9-19)26(39,27(29,30)31)28(32,33)34/h3-11,20,23,39H,12-17H2,1-2H3/t23-,25+/m0/s1 YXYVNJXYQMACDG-UKILVPOCSA-N 510598 US11078186, Example 52::US11078186, Example 86 Nuclear receptor ROR-gamma [262-507] 68.0 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510598 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510598&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search V27 6XFV 153313896 459627879 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068788 C[C@@]1(CN(C[C@H]1c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F)C(=O)Cc1ccccc1)c1ccccc1 InChI=1S/C28H25F6NO2/c1-25(21-10-6-3-7-11-21)18-35(24(36)16-19-8-4-2-5-9-19)17-23(25)20-12-14-22(15-13-20)26(37,27(29,30)31)28(32,33)34/h2-15,23,37H,16-18H2,1H3/t23-,25+/m0/s1 ZRWVKMUJBFEVBM-UKILVPOCSA-N 510599 US11078186, Example 53 Nuclear receptor ROR-gamma [262-507] 134 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510599 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510599&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 149559249 459627880 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068789 COC(=O)N1C[C@@H](c2ccc(cc2)C(O)(C(F)(F)F)C(F)(F)F)[C@](C)(C1)c1ccccc1 InChI=1S/C22H21F6NO3/c1-19(15-6-4-3-5-7-15)13-29(18(30)32-2)12-17(19)14-8-10-16(11-9-14)20(31,21(23,24)25)22(26,27)28/h3-11,17,31H,12-13H2,1-2H3/t17-,19+/m0/s1 PULFJZBMRUJPED-PKOBYXMFSA-N 510572 (3S,4S)-methyl 4-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl)-3-methyl-3-phenylpyrrolidine-1-carboxylate::US11078186, Example 26::US11078186, Example 54 Nuclear receptor ROR-gamma [262-507] 168 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510572 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510572&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 134499099 459627856 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068790 COC(=O)N1C[C@H](c2ccc(cc2)C(O)(C(F)(F)F)C(F)(F)F)[C@@](C)(C1)c1ccccc1 InChI=1S/C22H21F6NO3/c1-19(15-6-4-3-5-7-15)13-29(18(30)32-2)12-17(19)14-8-10-16(11-9-14)20(31,21(23,24)25)22(26,27)28/h3-11,17,31H,12-13H2,1-2H3/t17-,19+/m1/s1 PULFJZBMRUJPED-MJGOQNOKSA-N 510601 US11078186, Example 55 Nuclear receptor ROR-gamma [262-507] 141 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510601 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510601&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 153313922 459627881 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068791 CCOC(=O)N1C[C@@H](c2ccc(cc2)C(O)(C(F)(F)F)C(F)(F)F)[C@](C)(C1)c1ccccc1 InChI=1S/C23H23F6NO3/c1-3-33-19(31)30-13-18(20(2,14-30)16-7-5-4-6-8-16)15-9-11-17(12-10-15)21(32,22(24,25)26)23(27,28)29/h4-12,18,32H,3,13-14H2,1-2H3/t18-,20+/m0/s1 XYHMSZPCIZCSPX-AZUAARDMSA-N 510602 US11078186, Example 56::US11078186, Example 58 Nuclear receptor ROR-gamma [262-507] 126 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510602 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510602&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 149309349 459627882 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068792 CCOC(=O)N1C[C@H](c2ccc(cc2)C(O)(C(F)(F)F)C(F)(F)F)[C@@](C)(C1)c1ccccc1 InChI=1S/C23H23F6NO3/c1-3-33-19(31)30-13-18(20(2,14-30)16-7-5-4-6-8-16)15-9-11-17(12-10-15)21(32,22(24,25)26)23(27,28)29/h4-12,18,32H,3,13-14H2,1-2H3/t18-,20+/m1/s1 XYHMSZPCIZCSPX-QUCCMNQESA-N 510603 US11078186, Example 57 Nuclear receptor ROR-gamma [262-507] 255 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510603 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510603&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 149309350 459627883 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068793 CCOC(=O)N1C[C@@H](c2ccc(cc2)C(O)(C(F)(F)F)C(F)(F)F)[C@](C)(C1)c1ccccc1 InChI=1S/C23H23F6NO3/c1-3-33-19(31)30-13-18(20(2,14-30)16-7-5-4-6-8-16)15-9-11-17(12-10-15)21(32,22(24,25)26)23(27,28)29/h4-12,18,32H,3,13-14H2,1-2H3/t18-,20+/m0/s1 XYHMSZPCIZCSPX-AZUAARDMSA-N 510602 US11078186, Example 56::US11078186, Example 58 Nuclear receptor ROR-gamma [262-507] 164 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510602 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510602&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 149309349 459627882 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068794 CC(C)OC(=O)N1C[C@@H](c2ccc(cc2)C(O)(C(F)(F)F)C(F)(F)F)[C@](C)(C1)c1ccccc1 InChI=1S/C24H25F6NO3/c1-15(2)34-20(32)31-13-19(21(3,14-31)17-7-5-4-6-8-17)16-9-11-18(12-10-16)22(33,23(25,26)27)24(28,29)30/h4-12,15,19,33H,13-14H2,1-3H3/t19-,21+/m0/s1 DEHBEVASYZMWCT-PZJWPPBQSA-N 510605 US11078186, Example 59::US11078186, Example 61 Nuclear receptor ROR-gamma [262-507] 174 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510605 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510605&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 153313910 459627884 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068795 CC(C)OC(=O)N1C[C@H](c2ccc(cc2)C(O)(C(F)(F)F)C(F)(F)F)[C@@](C)(C1)c1ccccc1 InChI=1S/C24H25F6NO3/c1-15(2)34-20(32)31-13-19(21(3,14-31)17-7-5-4-6-8-17)16-9-11-18(12-10-16)22(33,23(25,26)27)24(28,29)30/h4-12,15,19,33H,13-14H2,1-3H3/t19-,21+/m1/s1 DEHBEVASYZMWCT-CTNGQTDRSA-N 510606 US11078186, Example 60 Nuclear receptor ROR-gamma [262-507] 136 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510606 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510606&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 153313956 459627885 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068796 CC(C)OC(=O)N1C[C@@H](c2ccc(cc2)C(O)(C(F)(F)F)C(F)(F)F)[C@](C)(C1)c1ccccc1 InChI=1S/C24H25F6NO3/c1-15(2)34-20(32)31-13-19(21(3,14-31)17-7-5-4-6-8-17)16-9-11-18(12-10-16)22(33,23(25,26)27)24(28,29)30/h4-12,15,19,33H,13-14H2,1-3H3/t19-,21+/m0/s1 DEHBEVASYZMWCT-PZJWPPBQSA-N 510605 US11078186, Example 59::US11078186, Example 61 Nuclear receptor ROR-gamma [262-507] 482 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510605 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510605&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 153313910 459627884 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068797 C[C@@]1(CN(C[C@H]1c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F)C(=O)Oc1ccccc1)c1ccccc1 InChI=1S/C27H23F6NO3/c1-24(19-8-4-2-5-9-19)17-34(23(35)37-21-10-6-3-7-11-21)16-22(24)18-12-14-20(15-13-18)25(36,26(28,29)30)27(31,32)33/h2-15,22,36H,16-17H2,1H3/t22-,24+/m0/s1 JDBXSCGVFYOEKP-LADGPHEKSA-N 510608 US11078186, Example 62 Nuclear receptor ROR-gamma [262-507] 260 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510608 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510608&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 148033636 459627886 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068798 C[C@@]1(CN(C[C@H]1c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F)C(=O)OCc1ccccc1)c1ccccc1 InChI=1S/C28H25F6NO3/c1-25(21-10-6-3-7-11-21)18-35(24(36)38-17-19-8-4-2-5-9-19)16-23(25)20-12-14-22(15-13-20)26(37,27(29,30)31)28(32,33)34/h2-15,23,37H,16-18H2,1H3/t23-,25+/m0/s1 QXLWCKRVFWGMJE-UKILVPOCSA-N 510609 US11078186, Example 63::US11078186, Example 65 Nuclear receptor ROR-gamma [262-507] 58.0 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510609 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510609&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 149112154 459627887 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068799 C[C@]1(CN(C[C@@H]1c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F)C(=O)OCc1ccccc1)c1ccccc1 InChI=1S/C28H25F6NO3/c1-25(21-10-6-3-7-11-21)18-35(24(36)38-17-19-8-4-2-5-9-19)16-23(25)20-12-14-22(15-13-20)26(37,27(29,30)31)28(32,33)34/h2-15,23,37H,16-18H2,1H3/t23-,25+/m1/s1 QXLWCKRVFWGMJE-NOZRDPDXSA-N 510610 US11078186, Example 64 Nuclear receptor ROR-gamma [262-507] 241 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510610 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510610&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 153313950 459627888 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068800 C[C@@]1(CN(C[C@H]1c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F)C(=O)OCc1ccccc1)c1ccccc1 InChI=1S/C28H25F6NO3/c1-25(21-10-6-3-7-11-21)18-35(24(36)38-17-19-8-4-2-5-9-19)16-23(25)20-12-14-22(15-13-20)26(37,27(29,30)31)28(32,33)34/h2-15,23,37H,16-18H2,1H3/t23-,25+/m0/s1 QXLWCKRVFWGMJE-UKILVPOCSA-N 510609 US11078186, Example 63::US11078186, Example 65 Nuclear receptor ROR-gamma [262-507] 140 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510609 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510609&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 149112154 459627887 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068801 CCNC(=O)N1C[C@@H](c2ccc(cc2)C(O)(C(F)(F)F)C(F)(F)F)[C@](C)(C1)c1ccccc1 InChI=1S/C23H24F6N2O2/c1-3-30-19(32)31-13-18(20(2,14-31)16-7-5-4-6-8-16)15-9-11-17(12-10-15)21(33,22(24,25)26)23(27,28)29/h4-12,18,33H,3,13-14H2,1-2H3,(H,30,32)/t18-,20+/m0/s1 LBTVYXPRSQYQBA-AZUAARDMSA-N 510612 US11078186, Example 66 Nuclear receptor ROR-gamma [262-507] 76.0 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510612 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510612&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 153313897 459627889 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068802 CC(C)NC(=O)N1C[C@@H](c2ccc(cc2)C(O)(C(F)(F)F)C(F)(F)F)[C@](C)(C1)c1ccccc1 InChI=1S/C24H26F6N2O2/c1-15(2)31-20(33)32-13-19(21(3,14-32)17-7-5-4-6-8-17)16-9-11-18(12-10-16)22(34,23(25,26)27)24(28,29)30/h4-12,15,19,34H,13-14H2,1-3H3,(H,31,33)/t19-,21+/m0/s1 VVAZODDXYNSFOO-PZJWPPBQSA-N 510613 US11078186, Example 67 Nuclear receptor ROR-gamma [262-507] 120 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510613 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510613&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 134506894 459627890 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068803 CC(C)(C)NC(=O)N1C[C@@H](c2ccc(cc2)C(O)(C(F)(F)F)C(F)(F)F)[C@](C)(C1)c1ccccc1 InChI=1S/C25H28F6N2O2/c1-21(2,3)32-20(34)33-14-19(22(4,15-33)17-8-6-5-7-9-17)16-10-12-18(13-11-16)23(35,24(26,27)28)25(29,30)31/h5-13,19,35H,14-15H2,1-4H3,(H,32,34)/t19-,22+/m0/s1 XISYNCICXZFEJB-SIKLNZKXSA-N 510614 US11078186, Example 68::US11078186, Example 70 Nuclear receptor ROR-gamma [262-507] 270 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510614 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510614&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 134506884 459627891 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068804 CC(C)(C)NC(=O)N1C[C@H](c2ccc(cc2)C(O)(C(F)(F)F)C(F)(F)F)[C@@](C)(C1)c1ccccc1 InChI=1S/C25H28F6N2O2/c1-21(2,3)32-20(34)33-14-19(22(4,15-33)17-8-6-5-7-9-17)16-10-12-18(13-11-16)23(35,24(26,27)28)25(29,30)31/h5-13,19,35H,14-15H2,1-4H3,(H,32,34)/t19-,22+/m1/s1 XISYNCICXZFEJB-KNQAVFIVSA-N 510615 US11078186, Example 69 Nuclear receptor ROR-gamma [262-507] 624 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510615 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510615&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 153313894 459627892 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068805 CC(C)(C)NC(=O)N1C[C@@H](c2ccc(cc2)C(O)(C(F)(F)F)C(F)(F)F)[C@](C)(C1)c1ccccc1 InChI=1S/C25H28F6N2O2/c1-21(2,3)32-20(34)33-14-19(22(4,15-33)17-8-6-5-7-9-17)16-10-12-18(13-11-16)23(35,24(26,27)28)25(29,30)31/h5-13,19,35H,14-15H2,1-4H3,(H,32,34)/t19-,22+/m0/s1 XISYNCICXZFEJB-SIKLNZKXSA-N 510614 US11078186, Example 68::US11078186, Example 70 Nuclear receptor ROR-gamma [262-507] 159 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510614 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510614&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 134506884 459627891 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068806 C[C@@]1(CN(C[C@H]1c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F)C(=O)Nc1ccccc1)c1ccccc1 InChI=1S/C27H24F6N2O2/c1-24(19-8-4-2-5-9-19)17-35(23(36)34-21-10-6-3-7-11-21)16-22(24)18-12-14-20(15-13-18)25(37,26(28,29)30)27(31,32)33/h2-15,22,37H,16-17H2,1H3,(H,34,36)/t22-,24+/m0/s1 XOCPXOUGOPPOJE-LADGPHEKSA-N 510617 US11078186, Example 71 Nuclear receptor ROR-gamma [262-507] 217 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510617 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510617&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 153313921 459627893 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068807 C[C@@]1(CN(C[C@H]1c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F)C(=O)NCc1ccccc1)c1ccccc1 InChI=1S/C28H26F6N2O2/c1-25(21-10-6-3-7-11-21)18-36(24(37)35-16-19-8-4-2-5-9-19)17-23(25)20-12-14-22(15-13-20)26(38,27(29,30)31)28(32,33)34/h2-15,23,38H,16-18H2,1H3,(H,35,37)/t23-,25+/m0/s1 MUPBMBQMORRYNG-UKILVPOCSA-N 510618 US11078186, Example 72::US11078186, Example 74 Nuclear receptor ROR-gamma [262-507] 37.0 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510618 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510618&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 148558836 459627894 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068808 C[C@]1(CN(C[C@@H]1c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F)C(=O)NCc1ccccc1)c1ccccc1 InChI=1S/C28H26F6N2O2/c1-25(21-10-6-3-7-11-21)18-36(24(37)35-16-19-8-4-2-5-9-19)17-23(25)20-12-14-22(15-13-20)26(38,27(29,30)31)28(32,33)34/h2-15,23,38H,16-18H2,1H3,(H,35,37)/t23-,25+/m1/s1 MUPBMBQMORRYNG-NOZRDPDXSA-N 510619 US11078186, Example 73 Nuclear receptor ROR-gamma [262-507] 1640 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510619 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510619&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 153313960 459627895 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068809 C[C@@]1(CN(C[C@H]1c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F)C(=O)NCc1ccccc1)c1ccccc1 InChI=1S/C28H26F6N2O2/c1-25(21-10-6-3-7-11-21)18-36(24(37)35-16-19-8-4-2-5-9-19)17-23(25)20-12-14-22(15-13-20)26(38,27(29,30)31)28(32,33)34/h2-15,23,38H,16-18H2,1H3,(H,35,37)/t23-,25+/m0/s1 MUPBMBQMORRYNG-UKILVPOCSA-N 510618 US11078186, Example 72::US11078186, Example 74 Nuclear receptor ROR-gamma [262-507] 20.0 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510618 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510618&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 148558836 459627894 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068810 CCS(=O)(=O)c1ccc(CNC(=O)N2C[C@H](c3ccc(cc3)C(O)(C(F)(F)F)C(F)(F)F)[C@@](C)(C2)c2ccccc2)cc1 InChI=1S/C30H30F6N2O4S/c1-3-43(41,42)24-15-9-20(10-16-24)17-37-26(39)38-18-25(27(2,19-38)22-7-5-4-6-8-22)21-11-13-23(14-12-21)28(40,29(31,32)33)30(34,35)36/h4-16,25,40H,3,17-19H2,1-2H3,(H,37,39)/t25-,27+/m1/s1 IQPMCGWRMVHGLH-VPUSJEBWSA-N 510621 US11078186, Example 75 Nuclear receptor ROR-gamma [262-507] 151 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510621 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510621&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 153313938 459627896 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068811 CCS(=O)(=O)c1ccc(CNC(=O)N2C[C@@H](c3ccc(cc3)C(O)(C(F)(F)F)C(F)(F)F)[C@](C)(C2)c2ccccc2)cc1 InChI=1S/C30H30F6N2O4S/c1-3-43(41,42)24-15-9-20(10-16-24)17-37-26(39)38-18-25(27(2,19-38)22-7-5-4-6-8-22)21-11-13-23(14-12-21)28(40,29(31,32)33)30(34,35)36/h4-16,25,40H,3,17-19H2,1-2H3,(H,37,39)/t25-,27+/m0/s1 IQPMCGWRMVHGLH-AHKZPQOWSA-N 510622 US11078186, Example 76 Nuclear receptor ROR-gamma [262-507] 71.0 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510622 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510622&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 153313924 459627897 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068812 C[C@]1(CN(C[C@@H]1c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F)C(=O)N1CCCC1)c1ccccc1 InChI=1S/C25H26F6N2O2/c1-22(18-7-3-2-4-8-18)16-33(21(34)32-13-5-6-14-32)15-20(22)17-9-11-19(12-10-17)23(35,24(26,27)28)25(29,30)31/h2-4,7-12,20,35H,5-6,13-16H2,1H3/t20-,22+/m1/s1 ZMRHLNCXQBUIJP-IRLDBZIGSA-N 510623 US11078186, Example 77 Nuclear receptor ROR-gamma [262-507] 422 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510623 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510623&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 153313951 459627898 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068813 C[C@@]1(CN(C[C@H]1c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F)C(=O)N1CCCC1)c1ccccc1 InChI=1S/C25H26F6N2O2/c1-22(18-7-3-2-4-8-18)16-33(21(34)32-13-5-6-14-32)15-20(22)17-9-11-19(12-10-17)23(35,24(26,27)28)25(29,30)31/h2-4,7-12,20,35H,5-6,13-16H2,1H3/t20-,22+/m0/s1 ZMRHLNCXQBUIJP-RBBKRZOGSA-N 510624 US11078186, Example 78 Nuclear receptor ROR-gamma [262-507] 179 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510624 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510624&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 153313917 459627899 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068814 CN1CCN(CC1)C(=O)N1C[C@H](c2ccc(cc2)C(O)(C(F)(F)F)C(F)(F)F)[C@@](C)(C1)c1ccccc1 InChI=1S/C26H29F6N3O2/c1-23(19-6-4-3-5-7-19)17-35(22(36)34-14-12-33(2)13-15-34)16-21(23)18-8-10-20(11-9-18)24(37,25(27,28)29)26(30,31)32/h3-11,21,37H,12-17H2,1-2H3/t21-,23+/m1/s1 XVLZAQCFEBLEBC-GGAORHGYSA-N 510625 US11078186, Example 79 Nuclear receptor ROR-gamma [262-507] 657 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510625 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510625&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 153313936 459627900 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068815 CN1CCN(CC1)C(=O)N1C[C@@H](c2ccc(cc2)C(O)(C(F)(F)F)C(F)(F)F)[C@](C)(C1)c1ccccc1 InChI=1S/C26H29F6N3O2/c1-23(19-6-4-3-5-7-19)17-35(22(36)34-14-12-33(2)13-15-34)16-21(23)18-8-10-20(11-9-18)24(37,25(27,28)29)26(30,31)32/h3-11,21,37H,12-17H2,1-2H3/t21-,23+/m0/s1 XVLZAQCFEBLEBC-JTHBVZDNSA-N 510626 US11078186, Example 80 Nuclear receptor ROR-gamma [262-507] 620 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510626 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510626&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 153313933 459627901 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068816 C[C@]1(CN(C[C@@H]1c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F)C(=O)N1CCOCC1)c1ccccc1 InChI=1S/C25H26F6N2O3/c1-22(18-5-3-2-4-6-18)16-33(21(34)32-11-13-36-14-12-32)15-20(22)17-7-9-19(10-8-17)23(35,24(26,27)28)25(29,30)31/h2-10,20,35H,11-16H2,1H3/t20-,22+/m1/s1 CNNXBZPLYLXMDI-IRLDBZIGSA-N 510627 US11078186, Example 81 Nuclear receptor ROR-gamma [262-507] 1007 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510627 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510627&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 147255563 459627902 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068817 C[C@@]1(CN(C[C@H]1c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F)C(=O)N1CCOCC1)c1ccccc1 InChI=1S/C25H26F6N2O3/c1-22(18-5-3-2-4-6-18)16-33(21(34)32-11-13-36-14-12-32)15-20(22)17-7-9-19(10-8-17)23(35,24(26,27)28)25(29,30)31/h2-10,20,35H,11-16H2,1H3/t20-,22+/m0/s1 CNNXBZPLYLXMDI-RBBKRZOGSA-N 510628 US11078186, Example 82 Nuclear receptor ROR-gamma [262-507] 214 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510628 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510628&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 153313927 459627903 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068818 C[C@@]1(CN(C[C@H]1c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F)S(C)(=O)=O)c1ccccc1 InChI=1S/C21H21F6NO3S/c1-18(15-6-4-3-5-7-15)13-28(32(2,30)31)12-17(18)14-8-10-16(11-9-14)19(29,20(22,23)24)21(25,26)27/h3-11,17,29H,12-13H2,1-2H3/t17-,18+/m0/s1 QEFHNUQIMHPUHY-ZWKOTPCHSA-N 510629 US11078186, Example 83 Nuclear receptor ROR-gamma [262-507] 546 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510629 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510629&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 153313944 459627904 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068819 C[C@@]1(CN(C[C@H]1c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccccc1)c1ccccc1 InChI=1S/C26H23F6NO3S/c1-23(19-8-4-2-5-9-19)17-33(37(35,36)21-10-6-3-7-11-21)16-22(23)18-12-14-20(15-13-18)24(34,25(27,28)29)26(30,31)32/h2-15,22,34H,16-17H2,1H3/t22-,23+/m0/s1 QSPATNKRYOTQIG-XZOQPEGZSA-N 510630 US11078186, Example 84 Nuclear receptor ROR-gamma [262-507] 801 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510630 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510630&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 153313931 459627905 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068820 CC(=O)N1CCC(CC1)C(=O)N1C[C@H](c2ccc(cc2)C(O)(C(F)(F)F)C(F)(F)F)[C@@](C)(C1)c1ccccc1 InChI=1S/C28H30F6N2O3/c1-18(37)35-14-12-20(13-15-35)24(38)36-16-23(25(2,17-36)21-6-4-3-5-7-21)19-8-10-22(11-9-19)26(39,27(29,30)31)28(32,33)34/h3-11,20,23,39H,12-17H2,1-2H3/t23-,25+/m1/s1 YXYVNJXYQMACDG-NOZRDPDXSA-N 510631 US11078186, Example 85 Nuclear receptor ROR-gamma [262-507] 2578 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510631 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510631&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 153313918 459627906 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068821 CC(=O)N1CCC(CC1)C(=O)N1C[C@@H](c2ccc(cc2)C(O)(C(F)(F)F)C(F)(F)F)[C@](C)(C1)c1ccccc1 InChI=1S/C28H30F6N2O3/c1-18(37)35-14-12-20(13-15-35)24(38)36-16-23(25(2,17-36)21-6-4-3-5-7-21)19-8-10-22(11-9-19)26(39,27(29,30)31)28(32,33)34/h3-11,20,23,39H,12-17H2,1-2H3/t23-,25+/m0/s1 YXYVNJXYQMACDG-UKILVPOCSA-N 510598 US11078186, Example 52::US11078186, Example 86 Nuclear receptor ROR-gamma [262-507] 77.0 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510598 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510598&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search V27 6XFV 153313896 459627879 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068822 C[C@@]1(CN(C[C@H]1c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F)C(=O)c1ccccc1)c1ccccc1 InChI=1S/C27H23F6NO2/c1-24(20-10-6-3-7-11-20)17-34(23(35)19-8-4-2-5-9-19)16-22(24)18-12-14-21(15-13-18)25(36,26(28,29)30)27(31,32)33/h2-15,22,36H,16-17H2,1H3/t22-,24+/m0/s1 QGXLQHDKLPYLDY-LADGPHEKSA-N 510633 US11078186, Example 87 Nuclear receptor ROR-gamma [262-507] 620 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510633 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510633&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 149037518 459627907 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068823 CCS(=O)(=O)c1ccc(CC(=O)N2C[C@H](c3ccc(cc3)C(O)(C(F)(F)F)C(F)(F)F)[C@@](C)(C2)c2ccccc2)cc1 InChI=1S/C30H29F6NO4S/c1-3-42(40,41)24-15-9-20(10-16-24)17-26(38)37-18-25(27(2,19-37)22-7-5-4-6-8-22)21-11-13-23(14-12-21)28(39,29(31,32)33)30(34,35)36/h4-16,25,39H,3,17-19H2,1-2H3/t25-,27+/m1/s1 IOXVMIOBUKRVKC-VPUSJEBWSA-N 510634 US11078186, Example 88 Nuclear receptor ROR-gamma [262-507] 72.0 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510634 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510634&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 147958057 459627908 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068824 CCS(=O)(=O)c1ccc(CC(=O)N2C[C@@H](c3ccc(cc3)C(O)(C(F)(F)F)C(F)(F)F)[C@](C)(C2)c2ccccc2)cc1 InChI=1S/C30H29F6NO4S/c1-3-42(40,41)24-15-9-20(10-16-24)17-26(38)37-18-25(27(2,19-37)22-7-5-4-6-8-22)21-11-13-23(14-12-21)28(39,29(31,32)33)30(34,35)36/h4-16,25,39H,3,17-19H2,1-2H3/t25-,27+/m0/s1 IOXVMIOBUKRVKC-AHKZPQOWSA-N 510635 US11078186, Example 89 Nuclear receptor ROR-gamma [262-507] 23.0 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510635 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510635&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 153313923 459627909 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068825 CCS(=O)(=O)c1ccc(CC(=O)N2C[C@@H](c3ccc(cc3)C(O)(C(F)(F)F)C(F)(F)F)[C@](C)(C2)c2ccc(F)cc2)cc1 InChI=1S/C30H28F7NO4S/c1-3-43(41,42)24-14-4-19(5-15-24)16-26(39)38-17-25(27(2,18-38)21-10-12-23(31)13-11-21)20-6-8-22(9-7-20)28(40,29(32,33)34)30(35,36)37/h4-15,25,40H,3,16-18H2,1-2H3/t25-,27+/m0/s1 YOADQVOANAJWIH-AHKZPQOWSA-N 510636 US11078186, Example 90::US11078186, Example 91 Nuclear receptor ROR-gamma [262-507] 41.0 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510636 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510636&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 149393643 459627910 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068826 CCS(=O)(=O)c1ccc(CC(=O)N2C[C@@H](c3ccc(cc3)C(O)(C(F)(F)F)C(F)(F)F)[C@](C)(C2)c2ccc(F)cc2)cc1 InChI=1S/C30H28F7NO4S/c1-3-43(41,42)24-14-4-19(5-15-24)16-26(39)38-17-25(27(2,18-38)21-10-12-23(31)13-11-21)20-6-8-22(9-7-20)28(40,29(32,33)34)30(35,36)37/h4-15,25,40H,3,16-18H2,1-2H3/t25-,27+/m0/s1 YOADQVOANAJWIH-AHKZPQOWSA-N 510636 US11078186, Example 90::US11078186, Example 91 Nuclear receptor ROR-gamma [262-507] 88.0 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510636 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510636&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 149393643 459627910 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068827 CCS(=O)(=O)c1ccc(CC(=O)N2C[C@H](c3ccc(cc3)C(O)(C(F)(F)F)C(F)(F)F)[C@@](C)(C2)c2ccc(F)cc2)cc1 InChI=1S/C30H28F7NO4S/c1-3-43(41,42)24-14-4-19(5-15-24)16-26(39)38-17-25(27(2,18-38)21-10-12-23(31)13-11-21)20-6-8-22(9-7-20)28(40,29(32,33)34)30(35,36)37/h4-15,25,40H,3,16-18H2,1-2H3/t25-,27+/m1/s1 YOADQVOANAJWIH-VPUSJEBWSA-N 510638 US11078186, Example 92 Nuclear receptor ROR-gamma [262-507] 239 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510638 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510638&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 149393644 459627911 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068828 CC(C)(C)OC(=O)N1CCC(CC1)C(=O)N1C[C@@H](c2ccc(cc2)C(O)(C(F)(F)F)C(F)(F)F)[C@](C)(C1)c1ccc(F)cc1 InChI=1S/C31H35F7N2O4/c1-27(2,3)44-26(42)39-15-13-20(14-16-39)25(41)40-17-24(28(4,18-40)21-9-11-23(32)12-10-21)19-5-7-22(8-6-19)29(43,30(33,34)35)31(36,37)38/h5-12,20,24,43H,13-18H2,1-4H3/t24-,28+/m0/s1 SMVCHVFCWYZJRM-RBJSKKJNSA-N 510639 US11078186, Example 93 Nuclear receptor ROR-gamma [262-507] 1305 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510639 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510639&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 134499346 459627912 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068829 C[C@@]1(CN(C[C@H]1c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F)C(=O)C1CCN(CC1)c1ccncc1)c1ccc(F)cc1 InChI=1S/C31H30F7N3O2/c1-28(22-6-8-24(32)9-7-22)19-41(27(42)21-12-16-40(17-13-21)25-10-14-39-15-11-25)18-26(28)20-2-4-23(5-3-20)29(43,30(33,34)35)31(36,37)38/h2-11,14-15,21,26,43H,12-13,16-19H2,1H3/t26-,28+/m0/s1 LYXQEWZLNWXBHZ-XTEPFMGCSA-N 510640 US11078186, Example 94 Nuclear receptor ROR-gamma [262-507] 299 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510640 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510640&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 153313912 459627913 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068830 CC(=O)N1CCC(CC1)C(=O)N1C[C@@H](c2ccc(cc2)C(O)(C(F)(F)F)C(F)(F)F)[C@](C)(C1)c1ccc(F)cc1 InChI=1S/C28H29F7N2O3/c1-17(38)36-13-11-19(12-14-36)24(39)37-15-23(25(2,16-37)20-7-9-22(29)10-8-20)18-3-5-21(6-4-18)26(40,27(30,31)32)28(33,34)35/h3-10,19,23,40H,11-16H2,1-2H3/t23-,25+/m0/s1 PLEBLNIHUKCNPF-UKILVPOCSA-N 510571 US11078186, Example 25::US11078186, Example 95::rac-1-(4-((3S,4S)-3-(4-fluorophenyl)-4-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl)-3-methylpyrrolidine-1-carbonyl)piperidin-1-yl)ethanone Nuclear receptor ROR-gamma [262-507] 108 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510571 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510571&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 134507077 459627855 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068831 CN(C)C(=O)c1ccc(cc1)C(=O)N1C[C@@H](c2ccc(cc2)C(O)(C(F)(F)F)C(F)(F)F)[C@](C)(C1)c1ccc(F)cc1 InChI=1S/C30H27F7N2O3/c1-27(21-12-14-23(31)15-13-21)17-39(26(41)20-6-4-19(5-7-20)25(40)38(2)3)16-24(27)18-8-10-22(11-9-18)28(42,29(32,33)34)30(35,36)37/h4-15,24,42H,16-17H2,1-3H3/t24-,27+/m0/s1 PNTDXBSMJOOYGK-RPLLCQBOSA-N 510642 US11078186, Example 96 Nuclear receptor ROR-gamma [262-507] 376 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510642 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510642&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 160258224 459627914 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068832 C[C@@]1(CN(C[C@H]1c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F)C(=O)Cc1ccc(cc1)C#N)c1ccc(F)cc1 InChI=1S/C29H23F7N2O2/c1-26(21-10-12-23(30)13-11-21)17-38(25(39)14-18-2-4-19(15-37)5-3-18)16-24(26)20-6-8-22(9-7-20)27(40,28(31,32)33)29(34,35)36/h2-13,24,40H,14,16-17H2,1H3/t24-,26+/m0/s1 AOLZSOKWRKQNJC-AZGAKELHSA-N 510643 US11078186, Example 97 Nuclear receptor ROR-gamma [262-507] 45.0 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510643 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510643&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 134499271 459627915 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068833 C[C@@]1(CN(C[C@H]1c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F)C(=O)Cc1cccnc1)c1ccc(F)cc1 InChI=1S/C27H23F7N2O2/c1-24(19-8-10-21(28)11-9-19)16-36(23(37)13-17-3-2-12-35-14-17)15-22(24)18-4-6-20(7-5-18)25(38,26(29,30)31)27(32,33)34/h2-12,14,22,38H,13,15-16H2,1H3/t22-,24+/m0/s1 GUYUFHZCPURWOO-LADGPHEKSA-N 510644 US11078186, Example 98 Nuclear receptor ROR-gamma [262-507] 87.0 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510644 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510644&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 147712380 459627916 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068834 C[C@@]1(CN(C[C@H]1c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F)C(=O)Cc1ccncc1)c1ccc(F)cc1 InChI=1S/C27H23F7N2O2/c1-24(19-6-8-21(28)9-7-19)16-36(23(37)14-17-10-12-35-13-11-17)15-22(24)18-2-4-20(5-3-18)25(38,26(29,30)31)27(32,33)34/h2-13,22,38H,14-16H2,1H3/t22-,24+/m0/s1 VCUXTHXPYCOGFC-LADGPHEKSA-N 510645 US11078186, Example 99 Nuclear receptor ROR-gamma [262-507] 69.0 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510645 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510645&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 153313906 459627917 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068835 C[C@@]1(CN(C[C@H]1c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F)C(=O)C1CCc2ccccc2C1)c1ccc(F)cc1 InChI=1S/C31H28F7NO2/c1-28(23-12-14-25(32)15-13-23)18-39(27(40)22-7-6-19-4-2-3-5-21(19)16-22)17-26(28)20-8-10-24(11-9-20)29(41,30(33,34)35)31(36,37)38/h2-5,8-15,22,26,41H,6-7,16-18H2,1H3/t22?,26-,28+/m0/s1 FFAGJXWGRYREAM-SDKBWILHSA-N 510646 US11078186, Example 100 Nuclear receptor ROR-gamma [262-507] 224 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510646 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510646&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 147488365 459627918 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068836 CC(C)(C)NC(=O)N1C[C@@H](c2ccc(cc2)C(O)(C(F)(F)F)C(F)(F)F)[C@](C)(C1)c1ccc(F)cc1 InChI=1S/C25H27F7N2O2/c1-21(2,3)33-20(35)34-13-19(22(4,14-34)16-9-11-18(26)12-10-16)15-5-7-17(8-6-15)23(36,24(27,28)29)25(30,31)32/h5-12,19,36H,13-14H2,1-4H3,(H,33,35)/t19-,22+/m0/s1 QKJNUHDUWYDGIL-SIKLNZKXSA-N 510647 US11078186, Example 101::US11078186, Example 102 Nuclear receptor ROR-gamma [262-507] 201 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510647 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510647&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 149054054 459627919 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068837 CC(C)(C)NC(=O)N1C[C@@H](c2ccc(cc2)C(O)(C(F)(F)F)C(F)(F)F)[C@](C)(C1)c1ccc(F)cc1 InChI=1S/C25H27F7N2O2/c1-21(2,3)33-20(35)34-13-19(22(4,14-34)16-9-11-18(26)12-10-16)15-5-7-17(8-6-15)23(36,24(27,28)29)25(30,31)32/h5-12,19,36H,13-14H2,1-4H3,(H,33,35)/t19-,22+/m0/s1 QKJNUHDUWYDGIL-SIKLNZKXSA-N 510647 US11078186, Example 101::US11078186, Example 102 Nuclear receptor ROR-gamma [262-507] 108 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510647 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510647&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 149054054 459627919 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068838 C[C@@]1(CN(C[C@H]1c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F)C(=O)NCc1ccccc1)c1ccc(F)cc1 InChI=1S/C28H25F7N2O2/c1-25(20-11-13-22(29)14-12-20)17-37(24(38)36-15-18-5-3-2-4-6-18)16-23(25)19-7-9-21(10-8-19)26(39,27(30,31)32)28(33,34)35/h2-14,23,39H,15-17H2,1H3,(H,36,38)/t23-,25+/m0/s1 VZZQWPNMECGJBM-UKILVPOCSA-N 510649 US11078186, Example 103::US11078186, Example 105 Nuclear receptor ROR-gamma [262-507] 142 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510649 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510649&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 134506902 459627920 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068839 C[C@]1(CN(C[C@@H]1c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F)C(=O)NCc1ccccc1)c1ccc(F)cc1 InChI=1S/C28H25F7N2O2/c1-25(20-11-13-22(29)14-12-20)17-37(24(38)36-15-18-5-3-2-4-6-18)16-23(25)19-7-9-21(10-8-19)26(39,27(30,31)32)28(33,34)35/h2-14,23,39H,15-17H2,1H3,(H,36,38)/t23-,25+/m1/s1 VZZQWPNMECGJBM-NOZRDPDXSA-N 510650 US11078186, Example 104 Nuclear receptor ROR-gamma [262-507] 1622 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510650 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510650&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 142348826 459627921 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068840 C[C@@]1(CN(C[C@H]1c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F)C(=O)NCc1ccccc1)c1ccc(F)cc1 InChI=1S/C28H25F7N2O2/c1-25(20-11-13-22(29)14-12-20)17-37(24(38)36-15-18-5-3-2-4-6-18)16-23(25)19-7-9-21(10-8-19)26(39,27(30,31)32)28(33,34)35/h2-14,23,39H,15-17H2,1H3,(H,36,38)/t23-,25+/m0/s1 VZZQWPNMECGJBM-UKILVPOCSA-N 510649 US11078186, Example 103::US11078186, Example 105 Nuclear receptor ROR-gamma [262-507] 20.0 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510649 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510649&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 134506902 459627920 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068841 COc1ccc(CNC(=O)N2C[C@@H](c3ccc(cc3)C(O)(C(F)(F)F)C(F)(F)F)[C@](C)(C2)c2ccc(F)cc2)cc1 InChI=1S/C29H27F7N2O3/c1-26(20-9-11-22(30)12-10-20)17-38(25(39)37-15-18-3-13-23(41-2)14-4-18)16-24(26)19-5-7-21(8-6-19)27(40,28(31,32)33)29(34,35)36/h3-14,24,40H,15-17H2,1-2H3,(H,37,39)/t24-,26+/m0/s1 ZJWOHCMGUADUFY-AZGAKELHSA-N 510652 US11078186, Example 106 Nuclear receptor ROR-gamma [262-507] 76.0 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510652 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510652&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 134506901 459627922 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068842 CC(C)(NC(=O)N1C[C@@H](c2ccc(cc2)C(O)(C(F)(F)F)C(F)(F)F)[C@](C)(C1)c1ccc(F)cc1)c1ccccc1 InChI=1S/C30H29F7N2O2/c1-26(2,20-7-5-4-6-8-20)38-25(40)39-17-24(27(3,18-39)21-13-15-23(31)16-14-21)19-9-11-22(12-10-19)28(41,29(32,33)34)30(35,36)37/h4-16,24,41H,17-18H2,1-3H3,(H,38,40)/t24-,27+/m0/s1 DHOYAWNBWCMIIH-RPLLCQBOSA-N 510653 US11078186, Example 107 Nuclear receptor ROR-gamma [262-507] 157 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510653 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510653&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 153313904 459627923 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068843 C[C@@]1(CN(C[C@H]1c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F)C(=O)NCc1ccc2OCOc2c1)c1ccc(F)cc1 InChI=1S/C29H25F7N2O4/c1-26(19-7-9-21(30)10-8-19)15-38(25(39)37-13-17-2-11-23-24(12-17)42-16-41-23)14-22(26)18-3-5-20(6-4-18)27(40,28(31,32)33)29(34,35)36/h2-12,22,40H,13-16H2,1H3,(H,37,39)/t22-,26+/m0/s1 IVYCDZRSZPXSIU-BKMJKUGQSA-N 510654 US11078186, Example 108 Nuclear receptor ROR-gamma [262-507] 97.0 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510654 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510654&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 153313902 459627924 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068844 C[C@@]1(CN(C[C@H]1c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F)C(=O)Nc1cccc2ccccc12)c1ccc(F)cc1 InChI=1S/C31H25F7N2O2/c1-28(21-13-15-23(32)16-14-21)18-40(27(41)39-26-8-4-6-19-5-2-3-7-24(19)26)17-25(28)20-9-11-22(12-10-20)29(42,30(33,34)35)31(36,37)38/h2-16,25,42H,17-18H2,1H3,(H,39,41)/t25-,28+/m0/s1 GAZQDJIKAVUODY-LBNVMWSVSA-N 510655 US11078186, Example 109 Nuclear receptor ROR-gamma [262-507] 237 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510655 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510655&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 153313907 459627925 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068845 C[C@@]1(CN(C[C@H]1c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F)C(=O)Nc1ccc2ccccc2c1)c1ccc(F)cc1 InChI=1S/C31H25F7N2O2/c1-28(22-11-13-24(32)14-12-22)18-40(27(41)39-25-15-8-19-4-2-3-5-21(19)16-25)17-26(28)20-6-9-23(10-7-20)29(42,30(33,34)35)31(36,37)38/h2-16,26,42H,17-18H2,1H3,(H,39,41)/t26-,28+/m0/s1 YXBIRIPNSKNTFS-XTEPFMGCSA-N 510656 US11078186, Example 110 Nuclear receptor ROR-gamma [262-507] 140 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510656 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510656&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 153313916 459627926 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068846 C[C@@]1(CN(C[C@H]1c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F)C(=O)NCc1cccnc1)c1ccc(F)cc1 InChI=1S/C27H24F7N3O2/c1-24(19-8-10-21(28)11-9-19)16-37(23(38)36-14-17-3-2-12-35-13-17)15-22(24)18-4-6-20(7-5-18)25(39,26(29,30)31)27(32,33)34/h2-13,22,39H,14-16H2,1H3,(H,36,38)/t22-,24+/m0/s1 WUAJZLMZDSIAEL-LADGPHEKSA-N 510657 US11078186, Example 111 Nuclear receptor ROR-gamma [262-507] 103 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510657 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510657&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 153313919 459627927 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068847 C[C@@]1(CN(C[C@H]1c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F)C(=O)NCc1ccncc1)c1ccc(F)cc1 InChI=1S/C27H24F7N3O2/c1-24(19-6-8-21(28)9-7-19)16-37(23(38)36-14-17-10-12-35-13-11-17)15-22(24)18-2-4-20(5-3-18)25(39,26(29,30)31)27(32,33)34/h2-13,22,39H,14-16H2,1H3,(H,36,38)/t22-,24+/m0/s1 SJVMHDPAJABFAS-LADGPHEKSA-N 510658 US11078186, Example 112 Nuclear receptor ROR-gamma [262-507] 21.0 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510658 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510658&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 153313928 459627928 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068848 CCOC(=O)C(C)(C)NC(=O)N1C[C@@H](c2ccc(cc2)C(O)(C(F)(F)F)C(F)(F)F)[C@](C)(C1)c1ccc(F)cc1 InChI=1S/C27H29F7N2O4/c1-5-40-21(37)23(2,3)35-22(38)36-14-20(24(4,15-36)17-10-12-19(28)13-11-17)16-6-8-18(9-7-16)25(39,26(29,30)31)27(32,33)34/h6-13,20,39H,5,14-15H2,1-4H3,(H,35,38)/t20-,24+/m0/s1 WQSIKMZCIQILTH-GBXCKJPGSA-N 510659 US11078186, Example 113 Nuclear receptor ROR-gamma [262-507] 1163 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510659 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510659&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 153313915 459627929 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068849 CN(Cc1ccccc1)C(=O)N1C[C@@H](c2ccc(cc2)C(O)(C(F)(F)F)C(F)(F)F)[C@](C)(C1)c1ccc(F)cc1 InChI=1S/C29H27F7N2O2/c1-26(21-12-14-23(30)15-13-21)18-38(25(39)37(2)16-19-6-4-3-5-7-19)17-24(26)20-8-10-22(11-9-20)27(40,28(31,32)33)29(34,35)36/h3-15,24,40H,16-18H2,1-2H3/t24-,26+/m0/s1 ZXCJEBAXYGJPEZ-AZGAKELHSA-N 510660 US11078186, Example 114 Nuclear receptor ROR-gamma [262-507] 336 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510660 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510660&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 153313901 459627930 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068850 C[C@@]1(CN(C[C@H]1c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F)C(=O)N1CCC(C1)c1ccccc1)c1ccc(F)cc1 InChI=1S/C31H29F7N2O2/c1-28(23-11-13-25(32)14-12-23)19-40(27(41)39-16-15-22(17-39)20-5-3-2-4-6-20)18-26(28)21-7-9-24(10-8-21)29(42,30(33,34)35)31(36,37)38/h2-14,22,26,42H,15-19H2,1H3/t22?,26-,28+/m0/s1 QRUXDCGYHKIKSY-SDKBWILHSA-N 510661 US11078186, Example 115 Nuclear receptor ROR-gamma [262-507] 218 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510661 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510661&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 153313926 459627931 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068851 C[C@@]1(CN(C[C@H]1c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F)C(=O)N1CCC(C1)c1cccnc1)c1ccc(F)cc1 InChI=1S/C30H28F7N3O2/c1-27(22-8-10-24(31)11-9-22)18-40(26(41)39-14-12-21(16-39)20-3-2-13-38-15-20)17-25(27)19-4-6-23(7-5-19)28(42,29(32,33)34)30(35,36)37/h2-11,13,15,21,25,42H,12,14,16-18H2,1H3/t21?,25-,27+/m0/s1 DJFATLMUXZPOLD-DCRAVRKTSA-N 510662 US11078186, Example 116 Nuclear receptor ROR-gamma [262-507] 48.0 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510662 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510662&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 153313930 459627932 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068852 C[C@@]1(CN(C[C@H]1c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F)C(=O)N1CCC(C1)c1ccncc1)c1ccc(F)cc1 InChI=1S/C30H28F7N3O2/c1-27(22-6-8-24(31)9-7-22)18-40(26(41)39-15-12-21(16-39)19-10-13-38-14-11-19)17-25(27)20-2-4-23(5-3-20)28(42,29(32,33)34)30(35,36)37/h2-11,13-14,21,25,42H,12,15-18H2,1H3/t21?,25-,27+/m0/s1 BXWMQPYKUHLOIV-DCRAVRKTSA-N 510663 US11078186, Example 117 Nuclear receptor ROR-gamma [262-507] 94.0 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510663 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510663&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 153313953 459627933 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068853 C[C@@]1(CN(C[C@H]1c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F)C(=O)N1CCc2ccccc2C1)c1ccc(F)cc1 InChI=1S/C30H27F7N2O2/c1-27(22-10-12-24(31)13-11-22)18-39(26(40)38-15-14-19-4-2-3-5-21(19)16-38)17-25(27)20-6-8-23(9-7-20)28(41,29(32,33)34)30(35,36)37/h2-13,25,41H,14-18H2,1H3/t25-,27+/m0/s1 FJDCWUZHUDZOPB-AHKZPQOWSA-N 510664 US11078186, Example 118 Nuclear receptor ROR-gamma [262-507] 324 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510664 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510664&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 153313920 459627934 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068854 C[C@@]1(CN(C[C@H]1c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F)C(=O)C1CCN(CC1)C(=O)CC#N)c1ccc(F)cc1 InChI=1S/C29H28F7N3O3/c1-26(20-6-8-22(30)9-7-20)17-39(25(41)19-11-14-38(15-12-19)24(40)10-13-37)16-23(26)18-2-4-21(5-3-18)27(42,28(31,32)33)29(34,35)36/h2-9,19,23,42H,10-12,14-17H2,1H3/t23-,26+/m0/s1 JACZDQDBHYAEIU-JYFHCDHNSA-N 510665 US11078186, Example 119 Nuclear receptor ROR-gamma [262-507] 54.0 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510665 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510665&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 153313942 459627935 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068855 C[C@@]1(CN(C[C@H]1c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F)C(=O)C1CCN(CC1)C(=O)CO)c1ccc(F)cc1 InChI=1S/C28H29F7N2O4/c1-25(19-6-8-21(29)9-7-19)16-37(24(40)18-10-12-36(13-11-18)23(39)15-38)14-22(25)17-2-4-20(5-3-17)26(41,27(30,31)32)28(33,34)35/h2-9,18,22,38,41H,10-16H2,1H3/t22-,25+/m0/s1 ZSAIHERMGKDZLS-WIOPSUGQSA-N 510666 US11078186, Example 120 Nuclear receptor ROR-gamma [262-507] 314 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510666 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510666&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 153313900 459627936 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068856 COCC(=O)N1CCC(CC1)C(=O)N1C[C@@H](c2ccc(cc2)C(O)(C(F)(F)F)C(F)(F)F)[C@](C)(C1)c1ccc(F)cc1 InChI=1S/C29H31F7N2O4/c1-26(20-7-9-22(30)10-8-20)17-38(25(40)19-11-13-37(14-12-19)24(39)16-42-2)15-23(26)18-3-5-21(6-4-18)27(41,28(31,32)33)29(34,35)36/h3-10,19,23,41H,11-17H2,1-2H3/t23-,26+/m0/s1 WVOHMJUIXOIMSP-JYFHCDHNSA-N 510667 US11078186, Example 121 Nuclear receptor ROR-gamma [262-507] 194 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510667 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510667&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 153262716 459627937 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068857 C[C@@]1(CN(C[C@H]1c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F)C(=O)C1CCN(CC1)C(=O)C(N)=O)c1ccc(F)cc1 InChI=1S/C28H28F7N3O4/c1-25(18-6-8-20(29)9-7-18)15-38(23(40)17-10-12-37(13-11-17)24(41)22(36)39)14-21(25)16-2-4-19(5-3-16)26(42,27(30,31)32)28(33,34)35/h2-9,17,21,42H,10-15H2,1H3,(H2,36,39)/t21-,25+/m0/s1 CHCJZXNIBIVOCD-SQJMNOBHSA-N 510668 US11078186, Example 122 Nuclear receptor ROR-gamma [262-507] 83.0 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510668 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510668&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 153313935 459627938 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068858 CC(C)(C#N)C(=O)N1CCC(CC1)C(=O)N1C[C@@H](c2ccc(cc2)C(O)(C(F)(F)F)C(F)(F)F)[C@](C)(C1)c1ccc(F)cc1 InChI=1S/C31H32F7N3O3/c1-27(2,17-39)26(43)40-14-12-20(13-15-40)25(42)41-16-24(28(3,18-41)21-8-10-23(32)11-9-21)19-4-6-22(7-5-19)29(44,30(33,34)35)31(36,37)38/h4-11,20,24,44H,12-16,18H2,1-3H3/t24-,28+/m0/s1 HBMBEBAPOARFNK-RBJSKKJNSA-N 510669 US11078186, Example 123 Nuclear receptor ROR-gamma [262-507] 100.0 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510669 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510669&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 153313948 459627939 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068859 C[C@@]1(CN(C[C@H]1c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F)C(=O)C1CCN(CC1)C(=O)C1(CC1)C#N)c1ccc(F)cc1 InChI=1S/C31H30F7N3O3/c1-27(21-6-8-23(32)9-7-21)18-41(25(42)20-10-14-40(15-11-20)26(43)28(17-39)12-13-28)16-24(27)19-2-4-22(5-3-19)29(44,30(33,34)35)31(36,37)38/h2-9,20,24,44H,10-16,18H2,1H3/t24-,27+/m0/s1 ITDIWTHVNQRQGH-RPLLCQBOSA-N 510670 US11078186, Example 124 Nuclear receptor ROR-gamma [262-507] 89.0 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510670 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510670&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 153313940 459627940 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068860 C[C@@]1(CN(C[C@H]1c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F)C(=O)C1CCN(CC1)C(N)=O)c1ccc(F)cc1 InChI=1S/C27H28F7N3O3/c1-24(18-6-8-20(28)9-7-18)15-37(22(38)17-10-12-36(13-11-17)23(35)39)14-21(24)16-2-4-19(5-3-16)25(40,26(29,30)31)27(32,33)34/h2-9,17,21,40H,10-15H2,1H3,(H2,35,39)/t21-,24+/m0/s1 UQQGWBXOULNAGK-XUZZJYLKSA-N 510671 US11078186, Example 125 Nuclear receptor ROR-gamma [262-507] 135 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510671 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510671&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 153313913 459627941 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068861 C[C@@]1(CN(C[C@H]1c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F)C(=O)C1CCN(CC1)S(C)(=O)=O)c1ccc(F)cc1 InChI=1S/C27H29F7N2O4S/c1-24(19-7-9-21(28)10-8-19)16-35(23(37)18-11-13-36(14-12-18)41(2,39)40)15-22(24)17-3-5-20(6-4-17)25(38,26(29,30)31)27(32,33)34/h3-10,18,22,38H,11-16H2,1-2H3/t22-,24+/m0/s1 ALFCHQITUJBNBS-LADGPHEKSA-N 510672 US11078186, Example 126 Nuclear receptor ROR-gamma [262-507] 77.0 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510672 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510672&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 146964390 459627942 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068862 CC(=O)N1CCC(CC1)C(=O)N1C[C@@H](c2ccc(cc2)C(OCc2c(F)cccc2F)(C(F)(F)F)C(F)(F)F)[C@](C)(C1)c1ccccc1 InChI=1S/C35H34F8N2O3/c1-22(46)44-17-15-24(16-18-44)31(47)45-19-28(32(2,21-45)25-7-4-3-5-8-25)23-11-13-26(14-12-23)33(34(38,39)40,35(41,42)43)48-20-27-29(36)9-6-10-30(27)37/h3-14,24,28H,15-21H2,1-2H3/t28-,32+/m0/s1 DOADJXJPOUKJSR-GMCHKSTQSA-N 510673 US11078186, Example 127 Nuclear receptor ROR-gamma [262-507] 158 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510673 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510673&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 153313949 459627943 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068863 C[C@@]1(CN(C[C@H]1c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F)C(=O)C1CCN(C1)C(=O)CC#N)c1ccc(F)cc1 InChI=1S/C28H26F7N3O3/c1-25(19-6-8-21(29)9-7-19)16-38(24(40)18-11-13-37(14-18)23(39)10-12-36)15-22(25)17-2-4-20(5-3-17)26(41,27(30,31)32)28(33,34)35/h2-9,18,22,41H,10-11,13-16H2,1H3/t18?,22-,25+/m0/s1 ARIHQSXUHWSJHG-CHATWSTOSA-N 510674 US11078186, Example 128 Nuclear receptor ROR-gamma [262-507] 59.0 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510674 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510674&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 153313939 459627944 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068864 CC(=O)N1CCC(CC1)C(=O)N1C[C@@H](c2ccc(cc2)C(F)(C(F)(F)F)C(F)(F)F)[C@](C)(C1)c1ccc(F)cc1 InChI=1S/C28H28F8N2O2/c1-17(39)37-13-11-19(12-14-37)24(40)38-15-23(25(2,16-38)20-7-9-22(29)10-8-20)18-3-5-21(6-4-18)26(30,27(31,32)33)28(34,35)36/h3-10,19,23H,11-16H2,1-2H3/t23-,25+/m0/s1 NGSPJHSAVUXBGJ-UKILVPOCSA-N 510675 US11078186, Example 129 Nuclear receptor ROR-gamma [262-507] 359 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510675 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510675&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 153313905 459627945 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068865 C[C@@]1(CN(C[C@H]1c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1CCN(CC1)C(=O)CC#N)c1ccc(F)cc1 InChI=1S/C29H27F8N3O2/c1-26(20-6-8-22(30)9-7-20)17-40(25(42)19-11-14-39(15-12-19)24(41)10-13-38)16-23(26)18-2-4-21(5-3-18)27(31,28(32,33)34)29(35,36)37/h2-9,19,23H,10-12,14-17H2,1H3/t23-,26+/m0/s1 SWMCMILGBQHSRF-JYFHCDHNSA-N 510676 US11078186, Example 130 Nuclear receptor ROR-gamma [262-507] 38.0 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510676 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510676&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 153313957 459627946 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068866 C[C@@]1(CN(C[C@H]1c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)C(=O)Cc1ccc(cc1)C#N)c1ccc(F)cc1 InChI=1S/C29H22F8N2O/c1-26(21-10-12-23(30)13-11-21)17-39(25(40)14-18-2-4-19(15-38)5-3-18)16-24(26)20-6-8-22(9-7-20)27(31,28(32,33)34)29(35,36)37/h2-13,24H,14,16-17H2,1H3/t24-,26+/m0/s1 LCSGPCDXCIDZTM-AZGAKELHSA-N 510677 US11078186, Example 131 Nuclear receptor ROR-gamma [262-507] 69.0 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510677 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510677&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 148319792 459627947 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068867 C[C@@]1(CN(C[C@H]1c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)C(=O)c1ccncc1)c1ccc(F)cc1 InChI=1S/C26H20F8N2O/c1-23(18-6-8-20(27)9-7-18)15-36(22(37)17-10-12-35-13-11-17)14-21(23)16-2-4-19(5-3-16)24(28,25(29,30)31)26(32,33)34/h2-13,21H,14-15H2,1H3/t21-,23+/m0/s1 KPQMLZZPHMHDEB-JTHBVZDNSA-N 510678 US11078186, Example 132 Nuclear receptor ROR-gamma [262-507] 400 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510678 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510678&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 153313895 459627948 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068868 C[C@@]1(CN(C[C@H]1c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)C(=O)Cc1ccncc1)c1ccc(F)cc1 InChI=1S/C27H22F8N2O/c1-24(19-6-8-21(28)9-7-19)16-37(23(38)14-17-10-12-36-13-11-17)15-22(24)18-2-4-20(5-3-18)25(29,26(30,31)32)27(33,34)35/h2-13,22H,14-16H2,1H3/t22-,24+/m0/s1 FXRYRXZQDZKFJJ-LADGPHEKSA-N 510679 US11078186, Example 133 Nuclear receptor ROR-gamma [262-507] 59.0 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510679 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510679&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 147587882 459627949 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068869 C[C@@]1(CN(C[C@H]1c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)C(=O)NCc1ccccc1)c1ccc(F)cc1 InChI=1S/C28H24F8N2O/c1-25(20-11-13-22(29)14-12-20)17-38(24(39)37-15-18-5-3-2-4-6-18)16-23(25)19-7-9-21(10-8-19)26(30,27(31,32)33)28(34,35)36/h2-14,23H,15-17H2,1H3,(H,37,39)/t23-,25+/m0/s1 GLVVPWJDHUSGLA-UKILVPOCSA-N 510680 US11078186, Example 134 Nuclear receptor ROR-gamma [262-507] 133 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510680 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510680&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 153313909 459627950 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068870 C[C@@]1(CN(C[C@H]1c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)C(=O)N1CCC(C1)c1cccnc1)c1ccc(F)cc1 InChI=1S/C30H27F8N3O/c1-27(22-8-10-24(31)11-9-22)18-41(26(42)40-14-12-21(16-40)20-3-2-13-39-15-20)17-25(27)19-4-6-23(7-5-19)28(32,29(33,34)35)30(36,37)38/h2-11,13,15,21,25H,12,14,16-18H2,1H3/t21?,25-,27+/m0/s1 KMQRUQTZFAIJKJ-DCRAVRKTSA-N 510681 US11078186, Example 135 Nuclear receptor ROR-gamma [262-507] 394 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510681 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510681&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 153313941 459627951 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068871 C[C@@]1(CN(C[C@H]1c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)C(=O)N1CCC(C1)c1ccncc1)c1ccc(F)cc1 InChI=1S/C30H27F8N3O/c1-27(22-6-8-24(31)9-7-22)18-41(26(42)40-15-12-21(16-40)19-10-13-39-14-11-19)17-25(27)20-2-4-23(5-3-20)28(32,29(33,34)35)30(36,37)38/h2-11,13-14,21,25H,12,15-18H2,1H3/t21?,25-,27+/m0/s1 JRZLWCYYNNNYKB-DCRAVRKTSA-N 510682 US11078186, Example 136::US11078186, Example 137 Nuclear receptor ROR-gamma [262-507] 39.0 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510682 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510682&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 153313959 459627952 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068872 C[C@@]1(CN(C[C@H]1c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)C(=O)N1CCC(C1)c1ccncc1)c1ccc(F)cc1 InChI=1S/C30H27F8N3O/c1-27(22-6-8-24(31)9-7-22)18-41(26(42)40-15-12-21(16-40)19-10-13-39-14-11-19)17-25(27)20-2-4-23(5-3-20)28(32,29(33,34)35)30(36,37)38/h2-11,13-14,21,25H,12,15-18H2,1H3/t21?,25-,27+/m0/s1 JRZLWCYYNNNYKB-DCRAVRKTSA-N 510682 US11078186, Example 136::US11078186, Example 137 Nuclear receptor ROR-gamma [262-507] 61.0 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510682 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510682&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 153313959 459627952 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068873 CCS(=O)(=O)c1ccc(CC(=O)N2C[C@H]([C@@H](C2)c2ccc(cc2)C(O)(C(F)(F)F)C(F)(F)F)c2ccccc2)cc1 InChI=1S/C29H27F6NO4S/c1-2-41(39,40)23-14-8-19(9-15-23)16-26(37)36-17-24(20-6-4-3-5-7-20)25(18-36)21-10-12-22(13-11-21)27(38,28(30,31)32)29(33,34)35/h3-15,24-25,38H,2,16-18H2,1H3/t24-,25-/m0/s1 UXRAIIQAWBJCOB-DQEYMECFSA-N 510684 US11078186, Example 138 Nuclear receptor ROR-gamma [262-507] 77.0 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510684 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510684&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 153313947 459627953 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068874 CC(=O)N1CCC(CC1)C(=O)N1C[C@H]([C@@H](C1)c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F)c1ccccc1 InChI=1S/C27H28F6N2O3/c1-17(36)34-13-11-20(12-14-34)24(37)35-15-22(18-5-3-2-4-6-18)23(16-35)19-7-9-21(10-8-19)25(38,26(28,29)30)27(31,32)33/h2-10,20,22-23,38H,11-16H2,1H3/t22-,23-/m0/s1 QJRHDXUDCZCBTD-GOTSBHOMSA-N 510685 US11078186, Example 139 Nuclear receptor ROR-gamma [262-507] 4416 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510685 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510685&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 142348807 459627954 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068875 CC(C)(C)NC(=O)N1C[C@H]([C@@H](C1)c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F)c1ccccc1 InChI=1S/C24H26F6N2O2/c1-21(2,3)31-20(33)32-13-18(15-7-5-4-6-8-15)19(14-32)16-9-11-17(12-10-16)22(34,23(25,26)27)24(28,29)30/h4-12,18-19,34H,13-14H2,1-3H3,(H,31,33)/t18-,19-/m0/s1 PMPKGJVEGBPIOY-OALUTQOASA-N 510686 US11078186, Example 140 Nuclear receptor ROR-gamma [262-507] 4640 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510686 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510686&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 148934598 459627955 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068876 OC(c1ccc(cc1)[C@@H]1CN(C[C@H]1c1ccccc1)C(=O)NCc1ccccc1)(C(F)(F)F)C(F)(F)F InChI=1S/C27H24F6N2O2/c28-26(29,30)25(37,27(31,32)33)21-13-11-20(12-14-21)23-17-35(16-22(23)19-9-5-2-6-10-19)24(36)34-15-18-7-3-1-4-8-18/h1-14,22-23,37H,15-17H2,(H,34,36)/t22-,23-/m0/s1 FTPVPLPTWAUWEC-GOTSBHOMSA-N 510687 US11078186, Example 141 Nuclear receptor ROR-gamma [262-507] 256 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510687 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510687&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 153313898 459627956 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068877 CC(=O)N1CCC(CC1)C(=O)N1C[C@H](c2ccccc2)[C@@](C)(C1)c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C28H30F6N2O3/c1-18(37)35-14-12-20(13-15-35)24(38)36-16-23(19-6-4-3-5-7-19)25(2,17-36)21-8-10-22(11-9-21)26(39,27(29,30)31)28(32,33)34/h3-11,20,23,39H,12-17H2,1-2H3/t23-,25+/m1/s1 OXWAXMVYIICUEQ-NOZRDPDXSA-N 510688 US11078186, Example 142 Nuclear receptor ROR-gamma [262-507] 642 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510688 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510688&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 142348817 459627957 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068878 CC(C)(C)NC(=O)N1C[C@H](c2ccccc2)[C@@](C)(C1)c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C25H28F6N2O2/c1-21(2,3)32-20(34)33-14-19(16-8-6-5-7-9-16)22(4,15-33)17-10-12-18(13-11-17)23(35,24(26,27)28)25(29,30)31/h5-13,19,35H,14-15H2,1-4H3,(H,32,34)/t19-,22+/m1/s1 VORPYMQATNFHGR-KNQAVFIVSA-N 510689 US11078186, Example 143 Nuclear receptor ROR-gamma [262-507] 1310 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510689 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510689&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 153088546 459627958 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068879 C[C@]1(CN(C[C@@H]1c1ccccc1)C(=O)NCc1ccccc1)c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C28H26F6N2O2/c1-25(21-12-14-22(15-13-21)26(38,27(29,30)31)28(32,33)34)18-36(17-23(25)20-10-6-3-7-11-20)24(37)35-16-19-8-4-2-5-9-19/h2-15,23,38H,16-18H2,1H3,(H,35,37)/t23-,25+/m1/s1 XBTSCCZZJWSYDU-NOZRDPDXSA-N 510690 US11078186, Example 144 Nuclear receptor ROR-gamma [262-507] 463 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510690 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510690&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 153313943 459627959 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068880 CC[C@@]1(CN(C[C@H]1c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F)C(=O)C1CCN(CC1)C(C)=O)c1ccccc1 InChI=1S/C29H32F6N2O3/c1-3-26(22-7-5-4-6-8-22)18-37(25(39)21-13-15-36(16-14-21)19(2)38)17-24(26)20-9-11-23(12-10-20)27(40,28(30,31)32)29(33,34)35/h4-12,21,24,40H,3,13-18H2,1-2H3/t24-,26+/m0/s1 OCHULWDAJUKDBG-AZGAKELHSA-N 510691 US11078186, Example 145 Nuclear receptor ROR-gamma [262-507] 147 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510691 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510691&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 134506982 459627960 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068881 CC[C@@]1(CN(C[C@H]1c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F)C(=O)NC(C)(C)C)c1ccccc1 InChI=1S/C26H30F6N2O2/c1-5-23(18-9-7-6-8-10-18)16-34(21(35)33-22(2,3)4)15-20(23)17-11-13-19(14-12-17)24(36,25(27,28)29)26(30,31)32/h6-14,20,36H,5,15-16H2,1-4H3,(H,33,35)/t20-,23+/m0/s1 WPJLCGVWRKVYRL-NZQKXSOJSA-N 510692 US11078186, Example 146 Nuclear receptor ROR-gamma [262-507] 200 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510692 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510692&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 134506983 459627961 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068882 CC[C@@]1(CN(C[C@H]1c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F)C(=O)NCc1ccccc1)c1ccccc1 InChI=1S/C29H28F6N2O2/c1-2-26(22-11-7-4-8-12-22)19-37(25(38)36-17-20-9-5-3-6-10-20)18-24(26)21-13-15-23(16-14-21)27(39,28(30,31)32)29(33,34)35/h3-16,24,39H,2,17-19H2,1H3,(H,36,38)/t24-,26+/m0/s1 FIBSAWBZGJQYNR-AZGAKELHSA-N 510693 US11078186, Example 147 Nuclear receptor ROR-gamma [262-507] 190 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510693 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510693&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 134506964 459627962 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068883 OC(c1ccc(cc1)[C@@H]1CN(C[C@H]1Cc1ccccc1)C(=O)Cc1ccc(cc1)C#N)(C(F)(F)F)C(F)(F)F InChI=1S/C29H24F6N2O2/c30-28(31,32)27(39,29(33,34)35)24-12-10-22(11-13-24)25-18-37(17-23(25)14-19-4-2-1-3-5-19)26(38)15-20-6-8-21(16-36)9-7-20/h1-13,23,25,39H,14-15,17-18H2/t23-,25+/m1/s1 JUTBZVGFWFSWMV-NOZRDPDXSA-N 510694 US11078186, Example 148 Nuclear receptor ROR-gamma [262-507] 1278 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510694 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510694&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 153313925 459627963 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 1068884 OC(c1ccc(cc1)[C@@H]1CN(C[C@H]1Cc1ccccc1)C(=O)Cc1ccncc1)(C(F)(F)F)C(F)(F)F InChI=1S/C27H24F6N2O2/c28-26(29,30)25(37,27(31,32)33)22-8-6-20(7-9-22)23-17-35(24(36)15-19-10-12-34-13-11-19)16-21(23)14-18-4-2-1-3-5-18/h1-13,21,23,37H,14-17H2/t21-,23+/m1/s1 FUYMPWDDUBRYAT-GGAORHGYSA-N 510695 US11078186, Example 149 Nuclear receptor ROR-gamma [262-507] 303 US Patent 10.7270/Q2222XXZ aid1805757 US11078186 Duan, J; Jiang, B; Dhar, TG; Lu, Z; Gupta, AK; Karmakar, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=510695 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=430&target=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=510695&enzyme=Nuclear+receptor+ROR-gamma+%5B262-507%5D&column=ki&startPg=0&Increment=50&submit=Search 147573236 459627964 1 APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YMQ,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5G42,5G43,5G44,5G45,5G46,5IXK,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5VB3,5VB5,5VB6,5VB7,5VQK,5VQL,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6LO9,6LOA,6LOB,6LOC,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8