BindingDB Reactant_set_id Ligand SMILES Ligand InChI Ligand InChI Key BindingDB MonomerID BindingDB Ligand Name Target Name Target Source Organism According to Curator or DataSource Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) kon (M-1-s-1) koff (s-1) pH Temp (C) Curation/DataSource Article DOI BindingDB Entry DOI PMID PubChem AID Patent Number Authors Institution Link to Ligand in BindingDB Link to Target in BindingDB Link to Ligand-Target Pair in BindingDB Ligand HET ID in PDB PDB ID(s) for Ligand-Target Complex PubChem CID of Ligand PubChem SID of Ligand ChEBI ID of Ligand ChEMBL ID of Ligand DrugBank ID of Ligand IUPHAR_GRAC ID of Ligand KEGG ID of Ligand ZINC ID of Ligand Number of Protein Chains in Target (>1 implies a multichain complex) BindingDB Target Chain Sequence PDB ID(s) of Target Chain UniProt (SwissProt) Recommended Name of Target Chain UniProt (SwissProt) Entry Name of Target Chain UniProt (SwissProt) Primary ID of Target Chain UniProt (SwissProt) Secondary ID(s) of Target Chain UniProt (SwissProt) Alternative ID(s) of Target Chain UniProt (TrEMBL) Submitted Name of Target Chain UniProt (TrEMBL) Entry Name of Target Chain UniProt (TrEMBL) Primary ID of Target Chain UniProt (TrEMBL) Secondary ID(s) of Target Chain UniProt (TrEMBL) Alternative ID(s) of Target Chain 495904 NS(=O)(=O)c1cccc(-c2cnn(Cc3ccncc3)c2)c1-c1nn[nH]n1 InChI=1S/C16H14N8O2S/c17-27(25,26)14-3-1-2-13(15(14)16-20-22-23-21-16)12-8-19-24(10-12)9-11-4-6-18-7-5-11/h1-8,10H,9H2,(H2,17,25,26)(H,20,21,22,23) CMWLJBDJYWZICK-UHFFFAOYSA-N 262251 3-[1-(pyridin-4-ylmethyl)- 1H-pyrazol-4-yl]-2-(2H- tetrazol-5- yl)benzenesulfonamide::US9708336, 100 Metallo-beta-lactamase type 2 146 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262251 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262251&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823525 376224079 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 495907 NS(=O)(=O)c1cccc(-c2cnn(Cc3ccccn3)c2)c1-c1nn[nH]n1 InChI=1S/C16H14N8O2S/c17-27(25,26)14-6-3-5-13(15(14)16-20-22-23-21-16)11-8-19-24(9-11)10-12-4-1-2-7-18-12/h1-9H,10H2,(H2,17,25,26)(H,20,21,22,23) NHHBHDPGKPXIHL-UHFFFAOYSA-N 262252 3-[1-(pyridin-2-ylmethyl)- 1H-pyrazol-4-yl]-2-(2H- tetrazol-5- yl)benzenesulfonamide::US9708336, 101 Metallo-beta-lactamase type 2 517 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262252 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262252&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823526 376224080 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 495910 Cc1nccn1-c1nc(cs1)-c1cccc(c1-c1nn[nH]n1)S(N)(=O)=O InChI=1S/C14H12N8O2S2/c1-8-16-5-6-22(8)14-17-10(7-25-14)9-3-2-4-11(26(15,23)24)12(9)13-18-20-21-19-13/h2-7H,1H3,(H2,15,23,24)(H,18,19,20,21) VFCSWLRMJHEOHU-UHFFFAOYSA-N 262253 3-[2-(2-methyl-1H-imidazol- 1-yl)-1,3-thiazol-4-yl]-2- (2H-tetrazol-5- yl)benzenesulfonamide::US9708336, 102 Metallo-beta-lactamase type 2 174 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262253 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262253&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823527 376224081 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 495913 NS(=O)(=O)c1cccc(-c2csc(CN3CCOCC3)c2)c1-c1nn[nH]n1 InChI=1S/C16H18N6O3S2/c17-27(23,24)14-3-1-2-13(15(14)16-18-20-21-19-16)11-8-12(26-10-11)9-22-4-6-25-7-5-22/h1-3,8,10H,4-7,9H2,(H2,17,23,24)(H,18,19,20,21) UTUBCSZXLZUSCU-UHFFFAOYSA-N 262254 3-[5-(morpholin-4- ylmethyl)thiophen-3-yl]-2- (2H-tetrazol-5- yl)benzenesulfonamide::US9708336, 103 Metallo-beta-lactamase type 2 311 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262254 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262254&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823528 376224082 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 495916 NS(=O)(=O)c1cccc(-c2c[nH]c3nccnc23)c1-c1nn[nH]n1 InChI=1S/C13H10N8O2S/c14-24(22,23)9-3-1-2-7(10(9)12-18-20-21-19-12)8-6-17-13-11(8)15-4-5-16-13/h1-6H,(H,16,17)(H2,14,22,23)(H,18,19,20,21) NXAPOLPVAXUWPX-UHFFFAOYSA-N 262255 3-(5H-pyrrolo[2,3-b]pyrazin- 7-yl)-2-(2H-tetrazol-5- yl)benzenesulfonamide::US9708336, 104 Metallo-beta-lactamase type 2 287 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262255 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262255&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823529 376224083 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 495919 NS(=O)(=O)c1cccc(-c2cnn3ncccc23)c1-c1nn[nH]n1 InChI=1S/C13H10N8O2S/c14-24(22,23)11-5-1-3-8(12(11)13-17-19-20-18-13)9-7-16-21-10(9)4-2-6-15-21/h1-7H,(H2,14,22,23)(H,17,18,19,20) PDODCCAAFNUYLG-UHFFFAOYSA-N 262256 3-pyrazolo[1,5-b]pyridazin- 3-yl-2-(2H-tetrazol-5- yl)benzenesulfonamide::US9708336, 105 Metallo-beta-lactamase type 2 374 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262256 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262256&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823530 376224084 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 495922 CC(C)n1nccc1-c1cccc(c1-c1nn[nH]n1)S(N)(=O)=O InChI=1S/C13H15N7O2S/c1-8(2)20-10(6-7-15-20)9-4-3-5-11(23(14,21)22)12(9)13-16-18-19-17-13/h3-8H,1-2H3,(H2,14,21,22)(H,16,17,18,19) QURHGFJTIOEHIA-UHFFFAOYSA-N 262257 3-[1-(1-methylethyl)-1H- pyrazol-5-yl]-2-(2H-tetrazol- 5-yl)benzenesulfonamide::US9708336, 106 Metallo-beta-lactamase type 2 1799 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262257 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262257&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823531 376224085 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 495925 NS(=O)(=O)c1cccc(-c2cnn3CCCCc23)c1-c1nn[nH]n1 InChI=1S/C14H15N7O2S/c15-24(22,23)12-6-3-4-9(13(12)14-17-19-20-18-14)10-8-16-21-7-2-1-5-11(10)21/h3-4,6,8H,1-2,5,7H2,(H2,15,22,23)(H,17,18,19,20) KRSDUQKXFTVULU-UHFFFAOYSA-N 262258 3-(4,5,6,7- tetrahydropyrazolo[1,5- a]pyridin-3-yl)-2-(2H- tetrazol-5- yl)benzenesulfonamide::US9708336, 107 Metallo-beta-lactamase type 2 365 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262258 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262258&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823532 376224086 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 495928 Cc1sccc1-c1cccc(c1-c1nn[nH]n1)S(N)(=O)=O InChI=1S/C12H11N5O2S2/c1-7-8(5-6-20-7)9-3-2-4-10(21(13,18)19)11(9)12-14-16-17-15-12/h2-6H,1H3,(H2,13,18,19)(H,14,15,16,17) FMFISQVBVUCMGC-UHFFFAOYSA-N 262259 3-(2-methylthiophen-3-yl)-2- (2H-tetrazol-5- yl)benzenesulfonamide::US9708336, 108 Metallo-beta-lactamase type 2 255 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262259 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262259&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823533 376224087 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 495931 NS(=O)(=O)c1cccc(-c2cn(c3ncccc23)S(=O)(=O)c2ccccc2)c1-c1nn[nH]n1 InChI=1S/C20H15N7O4S2/c21-32(28,29)17-10-4-8-14(18(17)19-23-25-26-24-19)16-12-27(20-15(16)9-5-11-22-20)33(30,31)13-6-2-1-3-7-13/h1-12H,(H2,21,28,29)(H,23,24,25,26) GKLQFJBSJRLNRT-UHFFFAOYSA-N 262260 3-[1-(phensulfonyl)-1H- pyrrolo[2,3-b]pyridin-3-yl]- 2-(2H-tetrazol-5- yl)benzenesulfonamide::US9708336, 109 Metallo-beta-lactamase type 2 38.9 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262260 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262260&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823534 376224088 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 495934 CCOC(=O)CCn1cc(cn1)-c1cccc(c1-c1nn[nH]n1)S(N)(=O)=O InChI=1S/C15H17N7O4S/c1-2-26-13(23)6-7-22-9-10(8-17-22)11-4-3-5-12(27(16,24)25)14(11)15-18-20-21-19-15/h3-5,8-9H,2,6-7H2,1H3,(H2,16,24,25)(H,18,19,20,21) DKGJTLXQFFNXDG-UHFFFAOYSA-N 262261 US9708336, 110::ethyl 3-{4-[3-sulfamoyl-2- (2H-tetrazol-5-yl)phenyl]- 1H-pyrazol-1-yl}propanoate Metallo-beta-lactamase type 2 445 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262261 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262261&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823535 376224089 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 495937 Cc1nnc2ccc(cn12)-c1cccc(c1-c1nnn[nH]1)S(N)(=O)=O InChI=1S/C14H12N8O2S/c1-8-16-17-12-6-5-9(7-22(8)12)10-3-2-4-11(25(15,23)24)13(10)14-18-20-21-19-14/h2-7H,1H3,(H2,15,23,24)(H,18,19,20,21) RGWVYRCUONEDCW-UHFFFAOYSA-N 262262 3-(3-methyl- [1,2,4]triazolo[4,3-a]pyridin-6- yl)-2-(1H-tetrazol-5- yl)benzenesulfonamide::US9708336, 113 Metallo-beta-lactamase type 2 14830 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262262 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262262&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266373 376224090 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 495940 Cc1cc2nccn2cc1-c1cccc(c1-c1nnn[nH]1)S(N)(=O)=O InChI=1S/C15H13N7O2S/c1-9-7-13-17-5-6-22(13)8-11(9)10-3-2-4-12(25(16,23)24)14(10)15-18-20-21-19-15/h2-8H,1H3,(H2,16,23,24)(H,18,19,20,21) ZWWPDRXMSRYOOS-UHFFFAOYSA-N 262263 3-(7-methylimidazo[1,2-a] pyridin-6-yl)-2-(1H-tetrazol- 5-yl)benzenesulfonamide::US9708336, 115 Metallo-beta-lactamase type 2 544 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262263 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262263&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266387 376224091 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 495943 CN1CCN(CC1)c1cc(ccn1)-c1cccc(c1-c1nnn[nH]1)S(N)(=O)=O InChI=1S/C17H20N8O2S/c1-24-7-9-25(10-8-24)15-11-12(5-6-19-15)13-3-2-4-14(28(18,26)27)16(13)17-20-22-23-21-17/h2-6,11H,7-10H2,1H3,(H2,18,26,27)(H,20,21,22,23) LZZWYTHWBZXRIH-UHFFFAOYSA-N 262264 3-(2-(4-methylpiperazin-1- yl)pyridin-4-yl)-2-(1H- tetrazol-5- yl)benzenesulfonamide::US9708336, 116 Metallo-beta-lactamase type 2 226 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262264 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262264&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266389 376224092 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 495946 NS(=O)(=O)c1cccc(-c2ccc(nc2)-n2cccn2)c1-c1nnn[nH]1 InChI=1S/C15H12N8O2S/c16-26(24,25)12-4-1-3-11(14(12)15-19-21-22-20-15)10-5-6-13(17-9-10)23-8-2-7-18-23/h1-9H,(H2,16,24,25)(H,19,20,21,22) XGATZQJFKNOUJB-UHFFFAOYSA-N 262265 3-(6-(1H-pyrazol-1-yl)pyridin- 3-yl)-2-(1H-tetrazol-5- yl)benzenesulfonamide::US9708336, 117 Metallo-beta-lactamase type 2 134 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262265 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262265&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266372 376224093 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 495949 NS(=O)(=O)c1cccc(c1)-c1cccc(c1-c1nnn[nH]1)S(N)(=O)=O InChI=1S/C13H12N6O4S2/c14-24(20,21)9-4-1-3-8(7-9)10-5-2-6-11(25(15,22)23)12(10)13-16-18-19-17-13/h1-7H,(H2,14,20,21)(H2,15,22,23)(H,16,17,18,19) SSSXBZAMLWXRPM-UHFFFAOYSA-N 262266 2-(1H-tetrazol-5-yl)-[1,1'- biphenyl]-3,3'-disulfonamide::US9708336, 118 Metallo-beta-lactamase type 2 1330 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262266 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262266&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266334 376224094 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 495952 NS(=O)(=O)c1cccc(-c2cccc(CO)c2)c1-c1nnn[nH]1 InChI=1S/C14H13N5O3S/c15-23(21,22)12-6-2-5-11(13(12)14-16-18-19-17-14)10-4-1-3-9(7-10)8-20/h1-7,20H,8H2,(H2,15,21,22)(H,16,17,18,19) SITFMMVYUQHJIT-UHFFFAOYSA-N 262267 3'-(hydroxymethyl)-2-(1H- tetrazol-5-yl)-[1,1'-biphenyl]- 3-sulfonamide::US9708336, 119 Metallo-beta-lactamase type 2 548 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262267 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262267&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266342 376224095 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 495955 NS(=O)(=O)c1cccc(-c2cccc3C(=O)NCc23)c1-c1nnn[nH]1 InChI=1S/C15H12N6O3S/c16-25(23,24)12-6-2-4-9(13(12)14-18-20-21-19-14)8-3-1-5-10-11(8)7-17-15(10)22/h1-6H,7H2,(H,17,22)(H2,16,23,24)(H,18,19,20,21) MCEQJAJIAVYAHD-UHFFFAOYSA-N 262268 3-(1-oxoisoindolin-4-yl)-2- (1H-tetrazol-5- yl)benzenesulfonamide::US9708336, 120 Metallo-beta-lactamase type 2 777 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262268 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262268&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266348 376224096 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 495958 NS(=O)(=O)c1cccc(-c2cccc3CCCNc23)c1-c1nnn[nH]1 InChI=1S/C16H16N6O2S/c17-25(23,24)13-8-2-6-11(14(13)16-19-21-22-20-16)12-7-1-4-10-5-3-9-18-15(10)12/h1-2,4,6-8,18H,3,5,9H2,(H2,17,23,24)(H,19,20,21,22) AQULCWZUJMLCAL-UHFFFAOYSA-N 262269 3-(1,2,3,4-tetrahydroquinolin- 8-yl)-2-(1H-tetrazol-5- yl)benzenesulfonamide::US9708336, 121 Metallo-beta-lactamase type 2 373 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262269 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262269&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266351 376224097 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 495961 NS(=O)(=O)c1cccc(-c2cnc(nc2)N2CCCCC2)c1-c1nnn[nH]1 InChI=1S/C16H18N8O2S/c17-27(25,26)13-6-4-5-12(14(13)15-20-22-23-21-15)11-9-18-16(19-10-11)24-7-2-1-3-8-24/h4-6,9-10H,1-3,7-8H2,(H2,17,25,26)(H,20,21,22,23) SEXOODBECTYZLQ-UHFFFAOYSA-N 262270 3-(2-(piperidin-1-yl)pyrimidin- 5-yl)-2-(1H-tetrazol-5- yl)benzenesulfonamide::US9708336, 122 Metallo-beta-lactamase type 2 63.1 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262270 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262270&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266343 376224098 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 495964 NS(=O)(=O)c1cccc(-c2cnc(NC3CC3)nc2)c1-c1nnn[nH]1 InChI=1S/C14H14N8O2S/c15-25(23,24)11-3-1-2-10(12(11)13-19-21-22-20-13)8-6-16-14(17-7-8)18-9-4-5-9/h1-3,6-7,9H,4-5H2,(H2,15,23,24)(H,16,17,18)(H,19,20,21,22) SZEQHVLIMIPQMF-UHFFFAOYSA-N 262271 3-(2- (cyclopropylamino)pyrimidin- 5-yl)-2-(1H-tetrazol-5- yl)benzenesulfonamide::US9708336, 123 Metallo-beta-lactamase type 2 415 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262271 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262271&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266358 376224099 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496942 NC(=O)CCc1ccc(cc1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)C(F)(F)F InChI=1S/C17H15F3N6O3S/c18-17(19,20)12-7-6-11(10-4-1-9(2-5-10)3-8-13(21)27)14(15(12)30(22,28)29)16-23-25-26-24-16/h1-2,4-7H,3,8H2,(H2,21,27)(H2,22,28,29)(H,23,24,25,26) CGDLGRZQXINUDW-UHFFFAOYSA-N 262597 3-(3′-sulfamoyl-2′-(2H-tetrazol-5-yl)-4′-(trifluoromethyl)-[1,1′-biphenyl]-4-yl)propanamide::US9708336, 449 Metallo-beta-lactamase type 2 0.537 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262597 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262597&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823632 376224424 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496945 NS(=O)(=O)c1c(ccc(N2CCC(CC2)c2ccc(CO)cc2)c1-c1nn[nH]n1)C(F)(F)F InChI=1S/C20H21F3N6O3S/c21-20(22,23)15-5-6-16(17(18(15)33(24,31)32)19-25-27-28-26-19)29-9-7-14(8-10-29)13-3-1-12(11-30)2-4-13/h1-6,14,30H,7-11H2,(H2,24,31,32)(H,25,26,27,28) OPTYEAUJDDRQPR-UHFFFAOYSA-N 262598 3-(4-(4-(hydroxymethyl)phenyl)piperidin-1-yl)-2-(2H-tetrazol-5-yl)-6-(trifluoromethyl)benzenesulfonamide::US9708336, 450 Metallo-beta-lactamase type 2 1.28 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262598 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262598&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823633 376224425 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496948 N[C@H]1CCC(Cc2ccc(-c3ccnc4ccccc34)c(-c3nn[nH]n3)c2S(N)(=O)=O)CC1 262599 6-(((1s,4s)-4-aminocyclohexyl)methyl)-3-(quinolin-4-yl)-2-(2H-tetrazol-5-yl)benzenesulfonamide::US9708336, 451 Metallo-beta-lactamase type 2 47.1 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262599 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262599&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823634 376224426 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496951 NS(=O)(=O)c1c(CCC2CCNCC2)ccc(-c2ccnc3ccccc23)c1-c1nn[nH]n1 InChI=1S/C23H25N7O2S/c24-33(31,32)22-16(6-5-15-9-12-25-13-10-15)7-8-19(21(22)23-27-29-30-28-23)17-11-14-26-20-4-2-1-3-18(17)20/h1-4,7-8,11,14-15,25H,5-6,9-10,12-13H2,(H2,24,31,32)(H,27,28,29,30) NGXJFGAFMRZTFR-UHFFFAOYSA-N 262600 6-(2-(piperidin-4-yl)ethyl)-3-(quinolin-4-yl)-2-(2H-tetrazol-5-yl)benzenesulfonamide::US9708336, 452 Metallo-beta-lactamase type 2 125 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262600 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262600&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823635 376224427 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496954 NS(=O)(=O)c1c(CCC#N)ccc(-c2ccnc3ccccc23)c1-c1nn[nH]n1 InChI=1S/C19H15N7O2S/c20-10-3-4-12-7-8-15(13-9-11-22-16-6-2-1-5-14(13)16)17(18(12)29(21,27)28)19-23-25-26-24-19/h1-2,5-9,11H,3-4H2,(H2,21,27,28)(H,23,24,25,26) RDPUVCGQPGGUPP-UHFFFAOYSA-N 262601 6-(2-cyanoethyl)-3-(quinolin-4-yl)-2-(2H-tetrazol-5-yl)benzenesulfonamide::US9708336, 453 Metallo-beta-lactamase type 2 111 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262601 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262601&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823636 376224428 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496957 NS(=O)(=O)c1c(ccc(-c2ccnc3ccccc23)c1-c1nn[nH]n1)C1CCCCC1 InChI=1S/C22H22N6O2S/c23-31(29,30)21-15(14-6-2-1-3-7-14)10-11-18(20(21)22-25-27-28-26-22)16-12-13-24-19-9-5-4-8-17(16)19/h4-5,8-14H,1-3,6-7H2,(H2,23,29,30)(H,25,26,27,28) UZUICMGGMAONJT-UHFFFAOYSA-N 262602 6-cyclohexyl-3-(quinolin-4-yl)-2-(2H-tetrazol-5-yl)benzenesulfonamide::US9708336, 454 Metallo-beta-lactamase type 2 67.0 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262602 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262602&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118257127 376224429 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496960 NS(=O)(=O)c1c(ccc(-c2ccnc3ccccc23)c1-c1nn[nH]n1)C1CCCCC1 InChI=1S/C22H22N6O2S/c23-31(29,30)21-15(14-6-2-1-3-7-14)10-11-18(20(21)22-25-27-28-26-22)16-12-13-24-19-9-5-4-8-17(16)19/h4-5,8-14H,1-3,6-7H2,(H2,23,29,30)(H,25,26,27,28) UZUICMGGMAONJT-UHFFFAOYSA-N 262602 6-cyclohexyl-3-(quinolin-4-yl)-2-(2H-tetrazol-5-yl)benzenesulfonamide::US9708336, 454 Metallo-beta-lactamase type 2 1.93 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262602 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262602&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118257127 376224429 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496963 N[C@H]1CCC(Cc2ccc(-c3ccc(cc3)C3CCNCC3)c(-c3nn[nH]n3)c2S(N)(=O)=O)CC1 262603 4-(((1s,4s)-4-aminocyclohexyl)methyl)-4′-(piperidin-4-yl)-2-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-3-sulfonamide::US9708336, 455 Metallo-beta-lactamase type 2 6.29 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262603 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262603&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118265973 376224430 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496966 NS(=O)(=O)c1c(CC2CCNCC2)ccc(-c2ccc(cc2)C2CCNCC2)c1-c1nn[nH]n1 InChI=1S/C24H31N7O2S/c25-34(32,33)23-20(15-16-7-11-26-12-8-16)5-6-21(22(23)24-28-30-31-29-24)19-3-1-17(2-4-19)18-9-13-27-14-10-18/h1-6,16,18,26-27H,7-15H2,(H2,25,32,33)(H,28,29,30,31) LHOHTNKBXFSQBC-UHFFFAOYSA-N 262604 4′-(piperidin-4-yl)-4-(piperidin-4-ylmethyl)-2-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-3-sulfonamide::US9708336, 456 Metallo-beta-lactamase type 2 9.79 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262604 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262604&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118257181 376224431 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496969 NC[C@H]1CC[C@H](Cc2ccc(-c3ccc(cc3)C3CCNCC3)c(-c3nn[nH]n3)c2S(N)(=O)=O)CC1 262605 4-(((1r,4r)-4-(aminomethyl)cyclohexyl)methyl)-4′-(piperidin-4-yl)-2-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-3-sulfonamide::US9708336, 457 Metallo-beta-lactamase type 2 3.05 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262605 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262605&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266606 376224432 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496972 NS(=O)(=O)c1c(CC(F)(F)F)ccc(-c2ccc(cc2)C2CCNCC2)c1-c1nn[nH]n1 InChI=1S/C20H21F3N6O2S/c21-20(22,23)11-15-5-6-16(17(18(15)32(24,30)31)19-26-28-29-27-19)14-3-1-12(2-4-14)13-7-9-25-10-8-13/h1-6,13,25H,7-11H2,(H2,24,30,31)(H,26,27,28,29) JZTYDZONNZUKRT-UHFFFAOYSA-N 262606 4′-(piperidin-4-yl)-2-(2H-tetrazol-5-yl)-4-(2,2,2- trifluoroethyl)-[1,1′-biphenyl]-3-sulfonamide::US9708336, 458 Metallo-beta-lactamase type 2 2.39 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262606 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262606&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266476 376224433 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496975 NC1CCC(CC1)c1ccc(-c2ccc(cc2)C2CCNCC2)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C24H31N7O2S/c25-19-7-5-18(6-8-19)21-10-9-20(22(23(21)34(26,32)33)24-28-30-31-29-24)17-3-1-15(2-4-17)16-11-13-27-14-12-16/h1-4,9-10,16,18-19,27H,5-8,11-14,25H2,(H2,26,32,33)(H,28,29,30,31) HFMOCKAFISSSQC-UHFFFAOYSA-N 262607 4-(4-aminocyclohexyl)-4′-(piperidin-4-yl)-2-(2H- tetrazol-5-yl)-[1,1′-biphenyl]-3-sulfonamide::US9708336, 459::US9708336, 460 Metallo-beta-lactamase type 2 86.6 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262607 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262607&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266477 376224434 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496978 NC1CCC(CC1)c1ccc(-c2ccc(cc2)C2CCNCC2)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C24H31N7O2S/c25-19-7-5-18(6-8-19)21-10-9-20(22(23(21)34(26,32)33)24-28-30-31-29-24)17-3-1-15(2-4-17)16-11-13-27-14-12-16/h1-4,9-10,16,18-19,27H,5-8,11-14,25H2,(H2,26,32,33)(H,28,29,30,31) HFMOCKAFISSSQC-UHFFFAOYSA-N 262607 4-(4-aminocyclohexyl)-4′-(piperidin-4-yl)-2-(2H- tetrazol-5-yl)-[1,1′-biphenyl]-3-sulfonamide::US9708336, 459::US9708336, 460 Metallo-beta-lactamase type 2 16.6 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262607 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262607&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266477 376224434 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496981 N[C@H]1CC[C@H](CCc2ccc(-c3ccc(cc3)C3CCNCC3)c(-c3nn[nH]n3)c2S(N)(=O)=O)CC1 262609 4-(2-((1r,4s)-4- aminocyclohexyl)ethyl)-4′-(piperidin-4-yl)-2-(2H- tetrazol-5-yl)-[1,1′-biphenyl]-3-sulfonamide::US9708336, 461 Metallo-beta-lactamase type 2 4.07 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262609 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262609&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118265972 376224435 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496984 N[C@H]1CC[C@@H](CCc2ccc(-c3ccc(cc3)C3CCNCC3)c(-c3nn[nH]n3)c2S(N)(=O)=O)CC1 262610 4-(2-((1s,4r)-4- aminocyclohexyl)ethyl)-4′-(piperidin-4-yl)-2-(2H- tetrazol-5-yl)-[1,1′-biphenyl]-3-sulfonamide::US9708336, 462 Metallo-beta-lactamase type 2 11.5 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262610 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262610&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118265972 376224436 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496987 N[C@H]1CCC(Cc2ccc(-c3ccc(cc3)C3CCNCC3)c(-c3nn[nH]n3)c2S(N)(=O)=O)CC1 262611 4-(((1r,4r)-4-aminocyclohexyl)methyl)-4′-(piperidin- 4-yl)-2-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-3- sulfonamide::US9708336, 463 Metallo-beta-lactamase type 2 6.58 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262611 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262611&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118265973 376224437 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496990 NS(=O)(=O)c1c(CC2(F)CCNCC2)ccc(-c2ccc(cc2)C2CCNCC2)c1-c1nn[nH]n1 InChI=1S/C24H30FN7O2S/c25-24(9-13-28-14-10-24)15-19-5-6-20(21(22(19)35(26,33)34)23-29-31-32-30-23)18-3-1-16(2-4-18)17-7-11-27-12-8-17/h1-6,17,27-28H,7-15H2,(H2,26,33,34)(H,29,30,31,32) GRGWHWUIYWRYID-UHFFFAOYSA-N 262612 4-((4-fluoropiperidin-4-yl)methyl)-4′-(piperidin-4-yl)- 2-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-3-sulfonamide::US9708336, 464 Metallo-beta-lactamase type 2 18.7 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262612 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262612&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266261 376224438 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496993 NS(=O)(=O)c1c(CC2CCNCC2(F)F)ccc(-c2ccc(cc2)C2CCNCC2)c1-c1nn[nH]n1 262613 4-((3,3-difluoropiperidin-4-yl)methyl)-4′-(piperidin-4- yl)-2-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-3-sulfonamide::US9708336, 465 Metallo-beta-lactamase type 2 3.31 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262613 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262613&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266281 376224439 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496996 NS(=O)(=O)c1c(CCC2CNC2)ccc(-c2ccc(cc2)C2CCNCC2)c1-c1nn[nH]n1 InChI=1S/C23H29N7O2S/c24-33(31,32)22-19(2-1-15-13-26-14-15)7-8-20(21(22)23-27-29-30-28-23)18-5-3-16(4-6-18)17-9-11-25-12-10-17/h3-8,15,17,25-26H,1-2,9-14H2,(H2,24,31,32)(H,27,28,29,30) CZPLSTYONNFOOT-UHFFFAOYSA-N 262614 4-(2-(azetidin-3-yl)ethyl)-4′-(piperidin-4-yl)-2-(2H- tetrazol-5-yl)-[1,1′-biphenyl]-3-sulfonamide::US9708336, 466 Metallo-beta-lactamase type 2 54.6 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262614 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262614&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266254 376224440 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496999 NS(=O)(=O)c1c(CC2(F)CCNC2)ccc(-c2ccc(cc2)C2CCNCC2)c1-c1nn[nH]n1 262615 4-((3-fluoropyrrolidin-3-yl)methyl)-4′-(piperidin-4- yl)-2-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-3-sulfonamide::US9708336, 467 Metallo-beta-lactamase type 2 34.8 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262615 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262615&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118265977 376224441 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497002 NS(=O)(=O)c1c(CC2CCNC2)ccc(-c2ccc(cc2)C2CCNCC2)c1-c1nn[nH]n1 262616 4′-(piperidin-4-yl)-4-(pyrrolidin-3-ylmethyl)-2-(2H- tetrazol-5-yl)-[1,1′-biphenyl]-3-sulfonamide::US9708336, 468 Metallo-beta-lactamase type 2 13.5 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262616 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262616&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118265976 376224442 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497005 NS(=O)(=O)c1c(CC2CNC2)ccc(-c2ccc(cc2)C2CCNCC2)c1-c1nn[nH]n1 InChI=1S/C22H27N7O2S/c23-32(30,31)21-18(11-14-12-25-13-14)5-6-19(20(21)22-26-28-29-27-22)17-3-1-15(2-4-17)16-7-9-24-10-8-16/h1-6,14,16,24-25H,7-13H2,(H2,23,30,31)(H,26,27,28,29) KBMBRJNMRZPMFY-UHFFFAOYSA-N 262617 4-(azetidin-3-ylmethyl)-4′-(piperidin-4-yl)-2-(2H- tetrazol-5-yl)-[1,1′-biphenyl]-3-sulfonamide::US9708336, 469 Metallo-beta-lactamase type 2 29.7 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262617 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262617&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118265978 376224443 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497464 CC(=O)NC1CCN(C1)c1ccc(cn1)-c1cccc(c1-c1nnn[nH]1)S(N)(=O)=O 262770 N-[1-[5-[3-sulfamoyl-2-(1H- tetrazol-5-yl)phenyl]-2- pyridyl]pyrrolidin-3- yl]acetamide::US9708336, 623 Metallo-beta-lactamase type 2 79.5 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262770 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262770&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266575 376224594 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497467 CC(C)(O)C1CN(C1)c1ccc(cn1)-c1cccc(c1-c1nnn[nH]1)S(N)(=O)=O InChI=1S/C18H21N7O3S/c1-18(2,26)12-9-25(10-12)15-7-6-11(8-20-15)13-4-3-5-14(29(19,27)28)16(13)17-21-23-24-22-17/h3-8,12,26H,9-10H2,1-2H3,(H2,19,27,28)(H,21,22,23,24) BXQDOSFRSPYFEE-UHFFFAOYSA-N 262771 3-[6-[3-(1-hydroxy-1-methyl- ethyl)azetidin-1-yl]-3-pyridyl]- 2-(1H-tetrazol-5- yl)benzenesulfonamide::US9708336, 624 Metallo-beta-lactamase type 2 86.2 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262771 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262771&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266573 376224595 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497470 CN(C)C1(C)CN(C1)c1ccc(cn1)-c1cccc(c1-c1nnn[nH]1)S(N)(=O)=O InChI=1S/C18H22N8O2S/c1-18(25(2)3)10-26(11-18)15-8-7-12(9-20-15)13-5-4-6-14(29(19,27)28)16(13)17-21-23-24-22-17/h4-9H,10-11H2,1-3H3,(H2,19,27,28)(H,21,22,23,24) WHVTVBJOYOWPEK-UHFFFAOYSA-N 262772 3-[6-[3-(dimethylamino)-3- methyl-azetidin-1-yl]-3- pyridyl]-2-(1H-tetrazol-5- yl)benzenesulfonamide::US9708336, 625 Metallo-beta-lactamase type 2 203 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262772 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262772&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266576 376224596 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497473 CC(C)(O)C1CCC(N1)c1ccc(cn1)-c1cccc(c1-c1nnn[nH]1)S(N)(=O)=O 262773 3-[6-[3-(1-hydroxy-1-methyl- ethyl)pyrrolidin-1-yl]-3- pyridyl]-2-(1H-tetrazol-5- yl)benzenesulfonamide::US9708336, 626 Metallo-beta-lactamase type 2 68.5 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262773 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262773&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 122694034 376224597 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497476 CN(C)C1CCN(C1)c1ccc(cn1)-c1cccc(c1-c1nnn[nH]1)S(N)(=O)=O 262774 3-[6-[3- (dimethylamino)pyrrolidin-1- yl]-3-pyridyl]-2-(1H-tetrazol- 5-yl)benzenesulfonamide::US9708336, 627 Metallo-beta-lactamase type 2 415 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262774 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262774&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266510 376224598 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497479 NS(=O)(=O)c1cccc(-c2ccc(NC3CCNC3)nc2)c1-c1nnn[nH]1 262775 3-[6-(pyrrolidin-3-ylamino)-3- pyridyl]-2-(1H-tetrazol-5- yl)benzenesulfonamide::US9708336, 628 Metallo-beta-lactamase type 2 650 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262775 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262775&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266502 376224599 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497482 CN(CCN1CCCC1)c1ccc(cn1)-c1cccc(c1-c1nnn[nH]1)S(N)(=O)=O InChI=1S/C19H24N8O2S/c1-26(11-12-27-9-2-3-10-27)17-8-7-14(13-21-17)15-5-4-6-16(30(20,28)29)18(15)19-22-24-25-23-19/h4-8,13H,2-3,9-12H2,1H3,(H2,20,28,29)(H,22,23,24,25) XPXZZVHBLREXBV-UHFFFAOYSA-N 262776 3-[6-[methyl(2-pyrrolidin-1- ylethyl)amino]-3-pyridyl]-2- (1H-tetrazol-5- yl)benzenesulfonamide::US9708336, 629 Metallo-beta-lactamase type 2 799 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262776 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262776&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266506 376224600 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497485 NS(=O)(=O)c1cccc(-c2ccc(nc2)N2CC(CN3CCCC3)C2)c1-c1nnn[nH]1 InChI=1S/C20H24N8O2S/c21-31(29,30)17-5-3-4-16(19(17)20-23-25-26-24-20)15-6-7-18(22-10-15)28-12-14(13-28)11-27-8-1-2-9-27/h3-7,10,14H,1-2,8-9,11-13H2,(H2,21,29,30)(H,23,24,25,26) OBQVGHGYUQLQRR-UHFFFAOYSA-N 262777 3-[6-[3-(pyrrolidin-1- ylmethyl)azetidin-1-yl]-3- pyridyl]-2-(1H-tetrazol-5- yl)benzenesulfonamide::US9708336, 630 Metallo-beta-lactamase type 2 388 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262777 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262777&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266505 376224601 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497488 CS(=O)(=O)C1CN(C1)c1ccc(cn1)-c1cccc(c1-c1nnn[nH]1)S(N)(=O)=O InChI=1S/C16H17N7O4S2/c1-28(24,25)11-8-23(9-11)14-6-5-10(7-18-14)12-3-2-4-13(29(17,26)27)15(12)16-19-21-22-20-16/h2-7,11H,8-9H2,1H3,(H2,17,26,27)(H,19,20,21,22) YENPWQRBTYXDFS-UHFFFAOYSA-N 262778 3-[6-(3- methylsulfonylazetidin-1-yl)- 3-pyridyl]-2-(1H-tetrazol-5- yl)benzenesulfonamide::US9708336, 631 Metallo-beta-lactamase type 2 39.9 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262778 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262778&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266507 376224602 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497491 CN1CCC2(CCN(C2)c2ccc(cn2)-c2cccc(c2-c2nnn[nH]2)S(N)(=O)=O)C1 262779 3-[6-(7-methyl-2,7- diazaspiro[4.4]nonan-2-yl)-3- pyridyl]-2-(1H-tetrazol-5- yl)benzenesulfonamide::US9708336, 632 Metallo-beta-lactamase type 2 254 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262779 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262779&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118265983 376224603 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497494 NS(=O)(=O)c1cccc(-c2ccc(nc2)N2CCC(O)C2)c1-c1nnn[nH]1 262780 3-[6-(3-hydroxypyrrolidin-1- yl)-3-pyridyl]-2-(1H-tetrazol- 5-yl)benzenesulfonamide::US9708336, 633 Metallo-beta-lactamase type 2 66.4 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262780 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262780&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118265992 376224604 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497497 NCCNc1ccc(cn1)-c1cccc(c1-c1nnn[nH]1)S(N)(=O)=O InChI=1S/C14H16N8O2S/c15-6-7-17-12-5-4-9(8-18-12)10-2-1-3-11(25(16,23)24)13(10)14-19-21-22-20-14/h1-5,8H,6-7,15H2,(H,17,18)(H2,16,23,24)(H,19,20,21,22) DGMURCCVDLPMEW-UHFFFAOYSA-N 262781 3-[6-(2-aminoethylamino)-3- pyridyl]-2-(1H-tetrazol-5- yl)benzenesulfonamide::US9708336, 634 Metallo-beta-lactamase type 2 1283 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262781 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262781&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118265993 376224605 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497500 CC1(O)CN(C1)c1ccc(cn1)-c1cccc(c1-c1nnn[nH]1)S(N)(=O)=O InChI=1S/C16H17N7O3S/c1-16(24)8-23(9-16)13-6-5-10(7-18-13)11-3-2-4-12(27(17,25)26)14(11)15-19-21-22-20-15/h2-7,24H,8-9H2,1H3,(H2,17,25,26)(H,19,20,21,22) YFBUWHSDJYXIER-UHFFFAOYSA-N 262782 3-[6-(3-hydroxy-3-methyl- azetidin-1-yl)-3-pyridyl]-2- (1H-tetrazol-5- yl)benzenesulfonamide::US9708336, 635 Metallo-beta-lactamase type 2 91.5 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262782 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262782&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118265985 376224606 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497503 NS(=O)(=O)c1cccc(-c2ccc(nc2)N2CC[C@@H]2CO)c1-c1nnn[nH]1 262783 3-[6-[(2S)-2- (hydroxymethyl)azetidin-1-yl]- 3-pyridyl]-2-(1H-tetrazol-5- yl)benzenesulfonamide::US9708336, 636 Metallo-beta-lactamase type 2 37.2 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262783 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262783&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118265980 376224607 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497506 CNCCN(C)c1ccc(cn1)-c1cccc(c1-c1nnn[nH]1)S(N)(=O)=O InChI=1S/C16H20N8O2S/c1-18-8-9-24(2)14-7-6-11(10-19-14)12-4-3-5-13(27(17,25)26)15(12)16-20-22-23-21-16/h3-7,10,18H,8-9H2,1-2H3,(H2,17,25,26)(H,20,21,22,23) MWGAZGWRRCMJER-UHFFFAOYSA-N 262784 3-[6-[methyl-[2- (methylamino)ethyl]amino]-3- pyridyl]-2-(1H-tetrazol-5- yl)benzenesulfonamide::US9708336, 637 Metallo-beta-lactamase type 2 925 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262784 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262784&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118265994 376224608 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497509 NS(=O)(=O)c1cccc(-c2ccc(NCC3CCN3)nc2)c1-c1nnn[nH]1 262785 3-[6-(azetidin-2- ylmethylamino)-3-pyridyl]-2- (1H-tetrazol-5- yl)benzenesulfonamide::US9708336, 638 Metallo-beta-lactamase type 2 596 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262785 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262785&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118265982 376224609 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497512 NCCNc1nc2c(cccc2s1)-c1cccc(c1-c1nn[nH]n1)S(N)(=O)=O InChI=1S/C16H16N8O2S2/c17-7-8-19-16-20-14-10(4-1-5-11(14)27-16)9-3-2-6-12(28(18,25)26)13(9)15-21-23-24-22-15/h1-6H,7-8,17H2,(H,19,20)(H2,18,25,26)(H,21,22,23,24) RAWVEWIYRBHAPO-UHFFFAOYSA-N 262786 3-[2-(2- aminoethylamino)-1,3- benzothiazol-4-yl]-2- (2H-tetrazol-5- yl)benzenesulfonamide::US9708336, 639 Metallo-beta-lactamase type 2 187 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262786 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262786&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266579 376224610 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497515 CN(C)CCNc1nc2c(cccc2s1)-c1cccc(c1-c1nn[nH]n1)S(N)(=O)=O InChI=1S/C18H20N8O2S2/c1-26(2)10-9-20-18-21-16-12(6-3-7-13(16)29-18)11-5-4-8-14(30(19,27)28)15(11)17-22-24-25-23-17/h3-8H,9-10H2,1-2H3,(H,20,21)(H2,19,27,28)(H,22,23,24,25) WWQNUIGEHLWCIA-UHFFFAOYSA-N 262787 3-[2-[2- (dimethylamino)ethylami- no]-1,3-benzothiazol-4- yl]-2-(2H-tetrazol-5- yl)benzenesulfonamide::US9708336, 640 Metallo-beta-lactamase type 2 194 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262787 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262787&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266580 376224611 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497518 N[C@H]1CC[C@@H](CC1)Nc1nc2c(cccc2s1)-c1cccc(c1-c1nnn[nH]1)S(N)(=O)=O 262788 3-[2-[(4- aminocyclohexyl)amino]- 1,3-benzothiazol-4-yl]- 2-(1H-tetrazol-5- yl)benzenesulfonamide::US9708336, 641 Metallo-beta-lactamase type 2 26.5 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262788 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262788&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 122687797 376224612 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497521 NCCCCNc1nc2c(cccc2s1)-c1cccc(c1-c1nnn[nH]1)S(N)(=O)=O InChI=1S/C18H20N8O2S2/c19-9-1-2-10-21-18-22-16-12(6-3-7-13(16)29-18)11-5-4-8-14(30(20,27)28)15(11)17-23-25-26-24-17/h3-8H,1-2,9-10,19H2,(H,21,22)(H2,20,27,28)(H,23,24,25,26) WBGUXJCBSVWMJO-UHFFFAOYSA-N 262789 3-[2-(4- aminobutylamino)-1,3- benzothiazol-4-yl]-2- (1H-tetrazol-5- yl)benzenesulfonamide::US9708336, 642 Metallo-beta-lactamase type 2 51.9 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262789 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262789&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266581 376224613 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497524 NCCCNc1nc2c(cccc2s1)-c1cccc(c1-c1nnn[nH]1)S(N)(=O)=O InChI=1S/C17H18N8O2S2/c18-8-3-9-20-17-21-15-11(5-1-6-12(15)28-17)10-4-2-7-13(29(19,26)27)14(10)16-22-24-25-23-16/h1-2,4-7H,3,8-9,18H2,(H,20,21)(H2,19,26,27)(H,22,23,24,25) SSTHSSODJCIRHW-UHFFFAOYSA-N 262790 3-[2-(3- aminopropylamino)-1,3- benzothiazol-4-yl]-2- (1H-tetrazol-5- yl)benzenesulfonamide::US9708336, 643 Metallo-beta-lactamase type 2 101 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262790 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262790&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266594 376224614 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497527 NCCCCCNc1nc2c(cccc2s1)-c1cccc(c1-c1nnn[nH]1)S(N)(=O)=O InChI=1S/C19H22N8O2S2/c20-10-2-1-3-11-22-19-23-17-13(7-4-8-14(17)30-19)12-6-5-9-15(31(21,28)29)16(12)18-24-26-27-25-18/h4-9H,1-3,10-11,20H2,(H,22,23)(H2,21,28,29)(H,24,25,26,27) SDXRYHFOGSJJMI-UHFFFAOYSA-N 262791 3-[2-(5- aminopentylamino)-1,3- benzothiazol-4-yl]-2- (1H-tetrazol-5- yl)benzenesulfonamide::US9708336, 644 Metallo-beta-lactamase type 2 32.4 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262791 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262791&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266020 376224615 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 495967 NS(=O)(=O)c1cccc(-c2cnc(NC3CCCC3)nc2)c1-c1nnn[nH]1 InChI=1S/C16H18N8O2S/c17-27(25,26)13-7-3-6-12(14(13)15-21-23-24-22-15)10-8-18-16(19-9-10)20-11-4-1-2-5-11/h3,6-9,11H,1-2,4-5H2,(H2,17,25,26)(H,18,19,20)(H,21,22,23,24) BQGJCYPXHRRLKH-UHFFFAOYSA-N 262272 3-(2- (cyclopentylamino)pyrimidin- 5-yl)-2-(1H-tetrazol-5- yl)benzenesulfonamide::US9708336, 124 Metallo-beta-lactamase type 2 68.9 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262272 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262272&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266363 376224100 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 495970 NS(=O)(=O)c1cccc(-c2cnc(NCCO)nc2)c1-c1nnn[nH]1 InChI=1S/C13H14N8O3S/c14-25(23,24)10-3-1-2-9(11(10)12-18-20-21-19-12)8-6-16-13(17-7-8)15-4-5-22/h1-3,6-7,22H,4-5H2,(H2,14,23,24)(H,15,16,17)(H,18,19,20,21) JBSLEZWJXJFILO-UHFFFAOYSA-N 262273 3-(2-((2- hydroxyethyl)amino)pyrimidin- 5-yl)-2-(1H-tetrazol-5- yl)benzenesulfonamide::US9708336, 125 Metallo-beta-lactamase type 2 326 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262273 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262273&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266368 376224101 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 495973 NS(=O)(=O)c1cccc(-c2cnn(CCN3CCOCC3)c2)c1-c1nnn[nH]1 InChI=1S/C16H20N8O3S/c17-28(25,26)14-3-1-2-13(15(14)16-19-21-22-20-16)12-10-18-24(11-12)5-4-23-6-8-27-9-7-23/h1-3,10-11H,4-9H2,(H2,17,25,26)(H,19,20,21,22) UCOSSSFRFHFTNI-UHFFFAOYSA-N 262274 3-(1-(2-morpholinoethyl)-1H- pyrazol-4-yl)-2-(1H-tetrazol-5- yl)benzenesulfonamide::US9708336, 126 Metallo-beta-lactamase type 2 864 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262274 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262274&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118265404 376224102 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 495976 Cn1cc2cc(ccc2n1)-c1cccc(c1-c1nnn[nH]1)S(N)(=O)=O InChI=1S/C15H13N7O2S/c1-22-8-10-7-9(5-6-12(10)19-22)11-3-2-4-13(25(16,23)24)14(11)15-17-20-21-18-15/h2-8H,1H3,(H2,16,23,24)(H,17,18,20,21) LYSZIIWCMURTIG-UHFFFAOYSA-N 262275 3-(2-methyl-2H-indazol-5-yl)- 2-(1H-tetrazol-5- yl)benzenesulfonamide::US9708336, 127 Metallo-beta-lactamase type 2 157 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262275 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262275&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823536 376224103 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 495979 CN1CCN(CC1)c1ncc(cn1)-c1cccc(c1-c1nnn[nH]1)S(N)(=O)=O InChI=1S/C16H19N9O2S/c1-24-5-7-25(8-6-24)16-18-9-11(10-19-16)12-3-2-4-13(28(17,26)27)14(12)15-20-22-23-21-15/h2-4,9-10H,5-8H2,1H3,(H2,17,26,27)(H,20,21,22,23) OTEQWHGCHGLCJW-UHFFFAOYSA-N 262276 3-(2-(4-methylpiperazin-1- yl)pyrimidin-5-yl)-2-(1H- tetrazol-5- yl)benzenesulfonamide::US9708336, 128 Metallo-beta-lactamase type 2 453 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262276 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262276&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823537 376224104 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 495982 NS(=O)(=O)c1cccc(-c2cc(F)cc(F)c2)c1-c1nnn[nH]1 InChI=1S/C13H9F2N5O2S/c14-8-4-7(5-9(15)6-8)10-2-1-3-11(23(16,21)22)12(10)13-17-19-20-18-13/h1-6H,(H2,16,21,22)(H,17,18,19,20) FOWFAFWACNOGOA-UHFFFAOYSA-N 262277 3',5'-difluoro-2-(1H-tetrazol-5- yl)-[1,1'-biphenyl]-3- sulfonamide::US9708336, 129 Metallo-beta-lactamase type 2 176 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262277 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262277&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823538 376224105 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 495985 NS(=O)(=O)c1cccc(-c2ccc3nonc3c2)c1-c1nnn[nH]1 InChI=1S/C13H9N7O3S/c14-24(21,22)11-3-1-2-8(12(11)13-15-19-20-16-13)7-4-5-9-10(6-7)18-23-17-9/h1-6H,(H2,14,21,22)(H,15,16,19,20) DWYKHBKBTUNZIO-UHFFFAOYSA-N 262278 3-(benzo[c][1,2,5]oxadiazol-5- yl)-2-(1H-tetrazol-5- yl)benzenesulfonamide::US9708336, 130 Metallo-beta-lactamase type 2 267 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262278 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262278&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823539 376224106 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 495988 Nc1[nH]nc2cc(ccc12)-c1cccc(c1-c1nnn[nH]1)S(N)(=O)=O InChI=1S/C14H12N8O2S/c15-13-9-5-4-7(6-10(9)17-18-13)8-2-1-3-11(25(16,23)24)12(8)14-19-21-22-20-14/h1-6H,(H3,15,17,18)(H2,16,23,24)(H,19,20,21,22) TXMPFIFVHHJTKU-UHFFFAOYSA-N 262279 3-(3-amino-2H-indazol-6- yl)-2-(1H-tetrazol-5- yl)benzenesulfonamide::US9708336, 131 Metallo-beta-lactamase type 2 187 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262279 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262279&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266528 376224107 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 495991 Nc1[nH]nc2ccc(cc12)-c1cccc(c1-c1nnn[nH]1)S(N)(=O)=O InChI=1S/C14H12N8O2S/c15-13-9-6-7(4-5-10(9)17-18-13)8-2-1-3-11(25(16,23)24)12(8)14-19-21-22-20-14/h1-6H,(H3,15,17,18)(H2,16,23,24)(H,19,20,21,22) ZVZMYCKPQXNTGK-UHFFFAOYSA-N 262280 3-(3-amino-2H-indazol-5- yl)-2-(1H-tetrazol-5- yl)benzenesulfonamide::US9708336, 132 Metallo-beta-lactamase type 2 755 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262280 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262280&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266524 376224108 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 495994 Nc1cc(cc(N)n1)-c1cccc(c1-c1nnn[nH]1)S(N)(=O)=O InChI=1S/C12H12N8O2S/c13-9-4-6(5-10(14)16-9)7-2-1-3-8(23(15,21)22)11(7)12-17-19-20-18-12/h1-5H,(H4,13,14,16)(H2,15,21,22)(H,17,18,19,20) MYQJQXNMWIVUPP-UHFFFAOYSA-N 262281 3-(2,6-diaminopyridin-4- yl)-2-(1H-tetrazol-5- yl)benzenesulfonamide::US9708336, 133 Metallo-beta-lactamase type 2 4922 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262281 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262281&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823540 376224109 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 495997 Nc1nc2c(cccc2s1)-c1cccc(c1-c1nnn[nH]1)S(N)(=O)=O InChI=1S/C14H11N7O2S2/c15-14-17-12-8(4-1-5-9(12)24-14)7-3-2-6-10(25(16,22)23)11(7)13-18-20-21-19-13/h1-6H,(H2,15,17)(H2,16,22,23)(H,18,19,20,21) HUXHHCLIJZRUQT-UHFFFAOYSA-N 262282 3-(2-aminobenzo[d]thiazol- 4-yl)-2-(1H-tetrazol-5- yl)benzenesulfonamide::US9708336, 134 Metallo-beta-lactamase type 2 22.6 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262282 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262282&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823541 376224110 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496000 COc1cc(ccn1)-c1cccc(c1-c1nnn[nH]1)S(N)(=O)=O InChI=1S/C13H12N6O3S/c1-22-11-7-8(5-6-15-11)9-3-2-4-10(23(14,20)21)12(9)13-16-18-19-17-13/h2-7H,1H3,(H2,14,20,21)(H,16,17,18,19) CLUQZXJQXHSHBD-UHFFFAOYSA-N 262283 3-(2-methoxypyridin-4-yl)- 2-(1H-tetrazol-5- yl)benzenesulfonamide::US9708336, 135 Metallo-beta-lactamase type 2 62.6 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262283 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262283&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823542 376224111 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496003 NS(=O)(=O)c1cccc(-c2cncc(c2)C#N)c1-c1nnn[nH]1 InChI=1S/C13H9N7O2S/c14-5-8-4-9(7-16-6-8)10-2-1-3-11(23(15,21)22)12(10)13-17-19-20-18-13/h1-4,6-7H,(H2,15,21,22)(H,17,18,19,20) JOACDQBBZNEWRY-UHFFFAOYSA-N 262284 3-(5-cyanopyridin-3-yl)-2- (1H-tetrazol-5- yl)benzenesulfonamide::US9708336, 136 Metallo-beta-lactamase type 2 1692 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262284 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262284&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823543 376224112 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496006 Nc1cncc(n1)-c1cccc(c1-c1nnn[nH]1)S(N)(=O)=O InChI=1S/C11H10N8O2S/c12-9-5-14-4-7(15-9)6-2-1-3-8(22(13,20)21)10(6)11-16-18-19-17-11/h1-5H,(H2,12,15)(H2,13,20,21)(H,16,17,18,19) VSSPOYNGTHKDPQ-UHFFFAOYSA-N 262285 3-(6-aminopyrazin-2-yl)-2- (1H-tetrazol-5- yl)benzenesulfonamide::US9708336, 137 Metallo-beta-lactamase type 2 2534 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262285 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262285&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823544 376224113 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496009 COc1ccc2cc(cnc2n1)-c1cccc(c1-c1nnn[nH]1)S(N)(=O)=O InChI=1S/C16H13N7O3S/c1-26-13-6-5-9-7-10(8-18-15(9)19-13)11-3-2-4-12(27(17,24)25)14(11)16-20-22-23-21-16/h2-8H,1H3,(H2,17,24,25)(H,20,21,22,23) HXBFEUZYAOGMLH-UHFFFAOYSA-N 262286 3-(7-methoxy-1,8- naphthyridin-3-yl)-2-(1H- tetrazol-5- yl)benzenesulfonamide::US9708336, 138 Metallo-beta-lactamase type 2 354 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262286 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262286&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118265356 376224114 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496012 Cc1cccn2c(cnc12)-c1cccc(c1-c1nnn[nH]1)S(N)(=O)=O InChI=1S/C15H13N7O2S/c1-9-4-3-7-22-11(8-17-15(9)22)10-5-2-6-12(25(16,23)24)13(10)14-18-20-21-19-14/h2-8H,1H3,(H2,16,23,24)(H,18,19,20,21) HZPJCVFFDAMKRH-UHFFFAOYSA-N 262287 3-(8-methylimidazo[1,2-a] pyridin-3-yl)-2-(1H- tetrazol-5- yl)benzenesulfonamide::US9708336, 139 Metallo-beta-lactamase type 2 98.4 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262287 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262287&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118265361 376224115 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496015 NS(=O)(=O)c1cccc(C2=CCOCC2)c1-c1nnn[nH]1 InChI=1S/C12H13N5O3S/c13-21(18,19)10-3-1-2-9(8-4-6-20-7-5-8)11(10)12-14-16-17-15-12/h1-4H,5-7H2,(H2,13,18,19)(H,14,15,16,17) JGRUUQVFXBXERT-UHFFFAOYSA-N 262288 3-(3,6-dihydro-2H-pyran- 4-yl)-2-(1H-tetrazol-5- yl)benzenesulfonamide::US9708336, 140 Metallo-beta-lactamase type 2 160 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262288 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262288&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118265352 376224116 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496018 NS(=O)(=O)c1cccc(C2=CCS(=O)(=O)CC2)c1-c1nnn[nH]1 InChI=1S/C12H13N5O4S2/c13-23(20,21)10-3-1-2-9(11(10)12-14-16-17-15-12)8-4-6-22(18,19)7-5-8/h1-4H,5-7H2,(H2,13,20,21)(H,14,15,16,17) AXEDRTIHBNWRAL-UHFFFAOYSA-N 262289 3-(1,1-dioxido-3,6- dihydro-2H-thiopyran-4- yl)-2-(1H-tetrazol-5- yl)benzenesulfonamide::US9708336, 141 Metallo-beta-lactamase type 2 2335 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262289 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262289&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118265353 376224117 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496021 NS(=O)(=O)c1cccc(COc2ccccc2)c1-c1nnn[nH]1 InChI=1S/C14H13N5O3S/c15-23(20,21)12-8-4-5-10(13(12)14-16-18-19-17-14)9-22-11-6-2-1-3-7-11/h1-8H,9H2,(H2,15,20,21)(H,16,17,18,19) KNOZHRULBGBCAG-UHFFFAOYSA-N 262290 3-(phenoxymethyl)-2- (1H-tetrazol-5- yl)benzenesulfonamide::US9708336, 142 Metallo-beta-lactamase type 2 81.0 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262290 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262290&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118265351 376224118 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496024 NS(=O)(=O)c1cccc(CCc2cccnc2)c1-c1nnn[nH]1 InChI=1S/C14H14N6O2S/c15-23(21,22)12-5-1-4-11(13(12)14-17-19-20-18-14)7-6-10-3-2-8-16-9-10/h1-5,8-9H,6-7H2,(H2,15,21,22)(H,17,18,19,20) NGVLNGZGXDYUFF-UHFFFAOYSA-N 262291 3-(2-pyridin-3-ylethyl)-2- (1H-tetrazol-5- yl)benzenesulfonamide::US9708336, 143 Metallo-beta-lactamase type 2 98.5 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262291 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262291&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118265354 376224119 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496027 NS(=O)(=O)c1cccc(CCc2ccccn2)c1-c1nnn[nH]1 InChI=1S/C14H14N6O2S/c15-23(21,22)12-6-3-4-10(13(12)14-17-19-20-18-14)7-8-11-5-1-2-9-16-11/h1-6,9H,7-8H2,(H2,15,21,22)(H,17,18,19,20) GUWZWOVRHUORNG-UHFFFAOYSA-N 262292 3-(2-pyridin-2-ylethyl)-2- (1H-tetrazol-5- yl)benzenesulfonamide::US9708336, 144 Metallo-beta-lactamase type 2 4500 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262292 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262292&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266674 376224120 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496030 NS(=O)(=O)c1cccc(C#CCC2CNCCO2)c1-c1nn[nH]n1 262293 3-(3-morpholin-2-ylprop-1- yn-1-yl)-2-(2H-tetrazol-5- yl)benzenesulfonamide::US9708336, 145 Metallo-beta-lactamase type 2 2410 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262293 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262293&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118265407 376224121 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497008 NS(=O)(=O)c1c(CC2CCNCC2)ccc(-c2ccc(cc2)C2CCN(CC3CNC3)CC2)c1-c1nn[nH]n1 InChI=1S/C28H38N8O2S/c29-39(37,38)27-24(15-19-7-11-30-12-8-19)5-6-25(26(27)28-32-34-35-33-28)23-3-1-21(2-4-23)22-9-13-36(14-10-22)18-20-16-31-17-20/h1-6,19-20,22,30-31H,7-18H2,(H2,29,37,38)(H,32,33,34,35) XRKDWDWEENVYSH-UHFFFAOYSA-N 262618 4′-(1-(azetidin-3-ylmethyl)piperidin-4-yl)-4-(piperidin-4-ylmethyl)-2-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-3-sulfonamide::US9708336, 470 Metallo-beta-lactamase type 2 3.23 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262618 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262618&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118256837 376224444 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497011 NS(=O)(=O)c1c(CC2CCN(CC3CNC3)CC2)ccc(-c2ccc(cc2)C2CCNCC2)c1-c1nn[nH]n1 InChI=1S/C28H38N8O2S/c29-39(37,38)27-24(15-19-9-13-36(14-10-19)18-20-16-31-17-20)5-6-25(26(27)28-32-34-35-33-28)23-3-1-21(2-4-23)22-7-11-30-12-8-22/h1-6,19-20,22,30-31H,7-18H2,(H2,29,37,38)(H,32,33,34,35) AMPYPJOXOJABJN-UHFFFAOYSA-N 262619 4-((1-(azetidin-3-ylmethyl)piperidin-4-yl)methyl)-4′-(piperidin-4-yl)-2-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-3-sulfonamide::US9708336, 471 Metallo-beta-lactamase type 2 8.68 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262619 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262619&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118257009 376224445 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497014 NC(=N)NC1CCC(CCc2ccc(-c3ccc(cc3)C3CCN(CC3)C(N)=N)c(-c3nn[nH]n3)c2S(N)(=O)=O)CC1 InChI=1S/C28H39N11O2S/c29-27(30)34-22-10-2-17(3-11-22)1-4-21-9-12-23(24(25(21)42(33,40)41)26-35-37-38-36-26)20-7-5-18(6-8-20)19-13-15-39(16-14-19)28(31)32/h5-9,12,17,19,22H,1-4,10-11,13-16H2,(H3,31,32)(H4,29,30,34)(H2,33,40,41)(H,35,36,37,38) OFAYAHNTVQHOFG-UHFFFAOYSA-N 262620 4-(4′-(2-(4-guanidinocyclohexyl)ethyl)-3′-sulfamoyl-2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)piperidine-1-carboximidamide::US9708336, 472 Metallo-beta-lactamase type 2 0.661 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262620 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262620&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118265979 376224446 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497017 NS(=O)(=O)c1c(CCC(F)(F)F)ccc(-c2ccc(cc2)C2CCNCC2)c1-c1nn[nH]n1 InChI=1S/C21H23F3N6O2S/c22-21(23,24)10-7-16-5-6-17(18(19(16)33(25,31)32)20-27-29-30-28-20)15-3-1-13(2-4-15)14-8-11-26-12-9-14/h1-6,14,26H,7-12H2,(H2,25,31,32)(H,27,28,29,30) DRHWUDZNZJXWRM-UHFFFAOYSA-N 262621 4′-(piperidin-4-yl)-2-(2H-tetrazol-5-yl)-4-(3,3,3-trifluoropropyl)-[1,1′-biphenyl]-3-sulfonamide::US9708336, 473 Metallo-beta-lactamase type 2 7.30 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262621 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262621&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118256996 376224447 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497020 NS(=O)(=O)c1c(ccc(-c2cnc3cc[nH]c3c2)c1-c1nnn[nH]1)C(F)(F)F InChI=1S/C15H10F3N7O2S/c16-15(17,18)9-2-1-8(7-5-11-10(21-6-7)3-4-20-11)12(13(9)28(19,26)27)14-22-24-25-23-14/h1-6,20H,(H2,19,26,27)(H,22,23,24,25) TVFBTLXEPYKCBH-UHFFFAOYSA-N 262622 3-(1H-pyrrolo[3,2-b]pyridin-6-yl)-2- (1H-tetrazol-5-yl)-6- (trifluoromethyl)benzenesulfonamide::US9708336, 474 Metallo-beta-lactamase type 2 3.91 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262622 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262622&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266587 376224448 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497023 Nc1ncc(cn1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)C(F)(F)F InChI=1S/C12H9F3N8O2S/c13-12(14,15)7-2-1-6(5-3-18-11(16)19-4-5)8(9(7)26(17,24)25)10-20-22-23-21-10/h1-4H,(H2,16,18,19)(H2,17,24,25)(H,20,21,22,23) YEGRJYIRBIJGGL-UHFFFAOYSA-N 262623 3-(2-aminopyrimidin-5-yl)-2-(1H- tetrazol-5-yl)-6- (trifluoromethyl)benzenesulfonamide::US9708336, 475 Metallo-beta-lactamase type 2 13.7 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262623 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262623&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266582 376224449 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497026 Nc1ncc(cc1F)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)C(F)(F)F InChI=1S/C13H9F4N7O2S/c14-8-3-5(4-20-11(8)18)6-1-2-7(13(15,16)17)10(27(19,25)26)9(6)12-21-23-24-22-12/h1-4H,(H2,18,20)(H2,19,25,26)(H,21,22,23,24) IVPCYUCDFAYFDI-UHFFFAOYSA-N 262624 3-(6-amino-5-fluoro-3-pyridyl)-2- (1H-tetrazol-5-yl)-6- (trifluoromethyl)benzenesulfonamide::US9708336, 476 Metallo-beta-lactamase type 2 3.98 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262624 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262624&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266597 376224450 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497029 Nc1n[nH]c2cc(ccc12)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)C(F)(F)F InChI=1S/C15H11F3N8O2S/c16-15(17,18)9-4-3-7(6-1-2-8-10(5-6)21-22-13(8)19)11(12(9)29(20,27)28)14-23-25-26-24-14/h1-5H,(H3,19,21,22)(H2,20,27,28)(H,23,24,25,26) VAYQVOFGZCTBMW-UHFFFAOYSA-N 262625 3-(3-amino-1H-indazol-6-yl)-2-(1H- tetrazol-5-yl)-6- (trifluoromethyl)benzenesulfonamide::US9708336, 477 Metallo-beta-lactamase type 2 6.38 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262625 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262625&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266588 376224451 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497032 Nc1ccnc2cc(ccc12)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)C(F)(F)F InChI=1S/C17H12F3N7O2S/c18-17(19,20)11-4-3-9(8-1-2-10-12(21)5-6-23-13(10)7-8)14(15(11)30(22,28)29)16-24-26-27-25-16/h1-7H,(H2,21,23)(H2,22,28,29)(H,24,25,26,27) OUEYWHFUSNVTBY-UHFFFAOYSA-N 262626 3-(4-amino-7-quinolyl)-2-(1-tetrazol- 5-yl)-6- (trifluoromethyl)benzenesulfonamide::US9708336, 478 Metallo-beta-lactamase type 2 88.1 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262626 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262626&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266589 376224452 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497035 Nc1ccnc2ccc(cc12)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)C(F)(F)F InChI=1S/C17H12F3N7O2S/c18-17(19,20)11-3-2-9(8-1-4-13-10(7-8)12(21)5-6-23-13)14(15(11)30(22,28)29)16-24-26-27-25-16/h1-7H,(H2,21,23)(H2,22,28,29)(H,24,25,26,27) HNIKIMABKSIQOH-UHFFFAOYSA-N 262627 3-(4-amino-6-quinolyl)-2-(1H- tetrazol-5-yl)-6- (trifluoromethyl)benzenesulfonamide::US9708336, 479 Metallo-beta-lactamase type 2 30.3 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262627 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262627&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266473 376224453 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497038 Nc1n[nH]c2ccc(cc12)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)C(F)(F)F InChI=1S/C15H11F3N8O2S/c16-15(17,18)9-3-2-7(6-1-4-10-8(5-6)13(19)22-21-10)11(12(9)29(20,27)28)14-23-25-26-24-14/h1-5H,(H3,19,21,22)(H2,20,27,28)(H,23,24,25,26) NWFYQBHUPUHMLK-UHFFFAOYSA-N 262628 3-(3-amino-1H-indazol-5-yl)-2-(1H- tetrazol-5-yl)-6- (trifluoromethyl)benzenesulfonamide::US9708336, 480 Metallo-beta-lactamase type 2 9.14 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262628 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262628&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266474 376224454 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497041 NS(=O)(=O)c1c(ccc(-c2ccc3nccn3c2)c1-c1nnn[nH]1)C(F)(F)F InChI=1S/C15H10F3N7O2S/c16-15(17,18)10-3-2-9(8-1-4-11-20-5-6-25(11)7-8)12(13(10)28(19,26)27)14-21-23-24-22-14/h1-7H,(H2,19,26,27)(H,21,22,23,24) PFRNSTVHCRBTSN-UHFFFAOYSA-N 262629 3-imidazo[1,2-a]pyridin-6-yl-2-(1H- tetrazol-5-yl)-6- (trifluoromethyl)benzenesulfonamide::US9708336, 481::US9708336, 484 Metallo-beta-lactamase type 2 7.11 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262629 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262629&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118256906 376224455 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497044 NC(=N)c1nc2c(cccc2s1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)C(F)(F)F InChI=1S/C16H11F3N8O2S2/c17-16(18,19)8-5-4-6(10(12(8)31(22,28)29)14-24-26-27-25-14)7-2-1-3-9-11(7)23-15(30-9)13(20)21/h1-5H,(H3,20,21)(H2,22,28,29)(H,24,25,26,27) SSFLYMMIUNKDPP-UHFFFAOYSA-N 262630 4-(3-Sulfamoyl-2-(1H-tetrazol-5-yl)-4-(trifluoromethyl)phenyl)benzo[d]thiazole-2-carboximidamide::US9708336, 482 Metallo-beta-lactamase type 2 7.24 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262630 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262630&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266262 376224456 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497047 NS(=O)(=O)c1c(ccc(-c2cccc3sc(nc23)C#N)c1-c1nnn[nH]1)C(F)(F)F InChI=1S/C16H8F3N7O2S2/c17-16(18,19)9-5-4-7(8-2-1-3-10-13(8)22-11(6-20)29-10)12(14(9)30(21,27)28)15-23-25-26-24-15/h1-5H,(H2,21,27,28)(H,23,24,25,26) CFRDZTYEGFLJAU-UHFFFAOYSA-N 262631 3-(2-Cyanobenzo[d]thiazol-4-yl)-2-(1H-tetrazol-5-yl)-6-(trifluoromethyl)benzenesulfonamide::US9708336, 483 Metallo-beta-lactamase type 2 2.12 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262631 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262631&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118257298 376224457 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497050 NS(=O)(=O)c1c(ccc(-c2ccc3nccn3c2)c1-c1nnn[nH]1)C(F)(F)F InChI=1S/C15H10F3N7O2S/c16-15(17,18)10-3-2-9(8-1-4-11-20-5-6-25(11)7-8)12(13(10)28(19,26)27)14-21-23-24-22-14/h1-7H,(H2,19,26,27)(H,21,22,23,24) PFRNSTVHCRBTSN-UHFFFAOYSA-N 262629 3-imidazo[1,2-a]pyridin-6-yl-2-(1H- tetrazol-5-yl)-6- (trifluoromethyl)benzenesulfonamide::US9708336, 481::US9708336, 484 Metallo-beta-lactamase type 2 6.58 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262629 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262629&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118256906 376224455 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497053 NS(=O)(=O)c1c(ccc(-c2cccn3cncc23)c1-c1nnn[nH]1)C(F)(F)F InChI=1S/C15H10F3N7O2S/c16-15(17,18)10-4-3-9(8-2-1-5-25-7-20-6-11(8)25)12(13(10)28(19,26)27)14-21-23-24-22-14/h1-7H,(H2,19,26,27)(H,21,22,23,24) LQGITVSXLVNNBD-UHFFFAOYSA-N 262633 3-(Imidazo[1,5-a]pyridin-8-yl)-2-(1H-tetrazol-5-yl)-6-(trifluoromethyl)benzenesulfonamide::US9708336, 485 Metallo-beta-lactamase type 2 4.98 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262633 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262633&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118256845 376224458 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497056 NS(=O)(=O)c1c(ccc(-c2cccc3ncccc23)c1-c1nn[nH]n1)C(F)(F)F InChI=1S/C17H11F3N6O2S/c18-17(19,20)12-7-6-11(9-3-1-5-13-10(9)4-2-8-22-13)14(15(12)29(21,27)28)16-23-25-26-24-16/h1-8H,(H2,21,27,28)(H,23,24,25,26) DMGNHLTVWFZHMF-UHFFFAOYSA-N 262634 3-(Quinolin-5-yl)-2-(2H-tetrazol-5-yl)-6-(trifluoromethyl)benzenesulfonamide::US9708336, 486 Metallo-beta-lactamase type 2 1.19 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262634 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262634&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118256898 376224459 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497059 Cc1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)C(F)(F)F InChI=1S/C9H8F3N5O2S/c1-4-2-3-5(9(10,11)12)7(20(13,18)19)6(4)8-14-16-17-15-8/h2-3H,1H3,(H2,13,18,19)(H,14,15,16,17) JYVBVIRETYBRTF-UHFFFAOYSA-N 262635 3-methyl-2-(1H-tetrazol-5-yl)-6- (trifluoromethyl)benzenesulfonamide::US9708336, 487 Metallo-beta-lactamase type 2 56.4 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262635 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262635&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266479 376224460 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497062 CC(C)c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)C(F)(F)F InChI=1S/C11H12F3N5O2S/c1-5(2)6-3-4-7(11(12,13)14)9(22(15,20)21)8(6)10-16-18-19-17-10/h3-5H,1-2H3,(H2,15,20,21)(H,16,17,18,19) BQISTLDDDOESCM-UHFFFAOYSA-N 262636 3-isopropyl-2-(1H-tetrazol-5-yl)-6- (trifluoromethyl)benzenesulfonamide::US9708336, 488 Metallo-beta-lactamase type 2 18.8 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262636 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262636&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266480 376224461 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497065 NS(=O)(=O)c1c(ccc(C2CC2)c1-c1nnn[nH]1)C(F)(F)F InChI=1S/C11H10F3N5O2S/c12-11(13,14)7-4-3-6(5-1-2-5)8(9(7)22(15,20)21)10-16-18-19-17-10/h3-5H,1-2H2,(H2,15,20,21)(H,16,17,18,19) NNCHKPBOFXYRAG-UHFFFAOYSA-N 262637 3-cyclopropyl-2-(1H-tetrazol-5-yl)-6- (trifluoromethyl)benzenesulfonamide::US9708336, 489 Metallo-beta-lactamase type 2 20.7 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262637 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262637&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266478 376224462 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497068 NS(=O)(=O)c1c(ccc(C2CCCC2)c1-c1nnn[nH]1)C(F)(F)F InChI=1S/C13H14F3N5O2S/c14-13(15,16)9-6-5-8(7-3-1-2-4-7)10(11(9)24(17,22)23)12-18-20-21-19-12/h5-7H,1-4H2,(H2,17,22,23)(H,18,19,20,21) YAIPXSFYLGKTSG-UHFFFAOYSA-N 262638 3-cyclopentyl-2-(1H-tetrazol-5-yl)-6- (trifluoromethyl)benzenesulfonamide::US9708336, 490 Metallo-beta-lactamase type 2 5.61 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262638 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262638&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266557 376224463 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497071 NS(=O)(=O)c1c(ccc(C2CCCCC2)c1-c1nnn[nH]1)C(F)(F)F InChI=1S/C14H16F3N5O2S/c15-14(16,17)10-7-6-9(8-4-2-1-3-5-8)11(12(10)25(18,23)24)13-19-21-22-20-13/h6-8H,1-5H2,(H2,18,23,24)(H,19,20,21,22) KEMBFYIRAFMFMT-UHFFFAOYSA-N 262639 3-cyclohexyl-2-(1H-tetrazol-5-yl)-6- (trifluoromethyl)benzenesulfonamide::US9708336, 491 Metallo-beta-lactamase type 2 1.11 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262639 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262639&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118257033 376224464 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497530 CN(CCCCN)c1nc2c(cccc2s1)-c1cccc(c1-c1nnn[nH]1)S(N)(=O)=O InChI=1S/C19H22N8O2S2/c1-27(11-3-2-10-20)19-22-17-13(7-4-8-14(17)30-19)12-6-5-9-15(31(21,28)29)16(12)18-23-25-26-24-18/h4-9H,2-3,10-11,20H2,1H3,(H2,21,28,29)(H,23,24,25,26) RATMVGAQTJUQLA-UHFFFAOYSA-N 262792 3-[2-[4- aminobutyl(methyl)amino]- 1,3-benzothiazol-4- yl]-2-(1H-tetrazol-5- yl)benzenesulfonamide::US9708336, 645 Metallo-beta-lactamase type 2 88.8 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262792 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262792&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266022 376224616 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497533 NS(=O)(=O)c1cccc(-c2cccc3sc(NC4CCN(CCF)CC4)nc23)c1-c1nnn[nH]1 InChI=1S/C21H23FN8O2S2/c22-9-12-30-10-7-13(8-11-30)24-21-25-19-15(4-1-5-16(19)33-21)14-3-2-6-17(34(23,31)32)18(14)20-26-28-29-27-20/h1-6,13H,7-12H2,(H,24,25)(H2,23,31,32)(H,26,27,28,29) AZMODNNJIQYJBI-UHFFFAOYSA-N 262793 3-[2-[[1-(2-fluoroethyl)- 4-piperidyl]amino]-1,3- benzothiazol-4-yl]-2- (1H-tetrazol-5- yl)benzenesulfonamide::US9708336, 646 Metallo-beta-lactamase type 2 31.8 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262793 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262793&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266023 376224617 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497536 NS(=O)(=O)c1cccc(-c2cnc3ncccn23)c1-c1nnn[nH]1 InChI=1S/C13H10N8O2S/c14-24(22,23)10-4-1-3-8(11(10)12-17-19-20-18-12)9-7-16-13-15-5-2-6-21(9)13/h1-7H,(H2,14,22,23)(H,17,18,19,20) ZCUYYPKNPWNJEN-UHFFFAOYSA-N 262794 3-imidazo[1,2-a]pyrimidin- 3-yl-2-(1H-tetrazol-5- yl)benzenesulfonamide::US9708336, 647 Metallo-beta-lactamase type 2 618 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262794 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262794&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266530 376224618 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497539 NS(=O)(=O)c1cccc(-c2cnc3ccc(cn23)C#N)c1-c1nnn[nH]1 InChI=1S/C15H10N8O2S/c16-6-9-4-5-13-18-7-11(23(13)8-9)10-2-1-3-12(26(17,24)25)14(10)15-19-21-22-20-15/h1-5,7-8H,(H2,17,24,25)(H,19,20,21,22) RQQREZCOCNALRY-UHFFFAOYSA-N 262795 3-(6-cyanoimidazo[1,2- a]pyridin-3-yl)-2-(1H- tetrazol-5- yl)benzenesulfonamide::US9708336, 648 Metallo-beta-lactamase type 2 95.7 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262795 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262795&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266517 376224619 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497542 NS(=O)(=O)c1cccc(-c2cnc3cccc(C#N)n23)c1-c1nnn[nH]1 InChI=1S/C15H10N8O2S/c16-7-9-3-1-6-13-18-8-11(23(9)13)10-4-2-5-12(26(17,24)25)14(10)15-19-21-22-20-15/h1-6,8H,(H2,17,24,25)(H,19,20,21,22) HUKSSEIEECQXPC-UHFFFAOYSA-N 262796 3-(5-cyanoimidazo[1,2- a]pyridin-3-yl)-2-(1H- tetrazol-5- yl)benzenesulfonamide::US9708336, 649 Metallo-beta-lactamase type 2 48.4 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262796 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262796&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266512 376224620 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497545 NS(=O)(=O)c1cccc(-c2cnc3nc(ccn23)C(F)(F)F)c1-c1nnn[nH]1 InChI=1S/C14H9F3N8O2S/c15-14(16,17)10-4-5-25-8(6-19-13(25)20-10)7-2-1-3-9(28(18,26)27)11(7)12-21-23-24-22-12/h1-6H,(H2,18,26,27)(H,21,22,23,24) OYDUBPRBUIXQBG-UHFFFAOYSA-N 262797 2-(1H-tetrazol-5-yl)-3-[7- (trifluoromethyl)imidazo[1,2- a]pyrimidin-3- yl]benzenesulfonamide::US9708336, 650 Metallo-beta-lactamase type 2 1262 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262797 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262797&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266515 376224621 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497548 NS(=O)(=O)c1cccc(-c2cnc3cnccn23)c1-c1nnn[nH]1 InChI=1S/C13H10N8O2S/c14-24(22,23)10-3-1-2-8(12(10)13-17-19-20-18-13)9-6-16-11-7-15-4-5-21(9)11/h1-7H,(H2,14,22,23)(H,17,18,19,20) NTFRRECSQCOMTQ-UHFFFAOYSA-N 262798 3-imidazo[1,2-a]pyrazin-3- yl-2-(1H-tetrazol-5- yl)benzenesulfonamide::US9708336, 651 Metallo-beta-lactamase type 2 900 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262798 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262798&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266516 376224622 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497551 NS(=O)(=O)c1cccc(-c2cnc3ccc(Cl)nn23)c1-c1nnn[nH]1 InChI=1S/C13H9ClN8O2S/c14-10-4-5-11-16-6-8(22(11)19-10)7-2-1-3-9(25(15,23)24)12(7)13-17-20-21-18-13/h1-6H,(H2,15,23,24)(H,17,18,20,21) WUCVLDZSLZVMFN-UHFFFAOYSA-N 262799 3-(6-chloroimidazo[1,2- b]pyridazin-3-yl)-2-(1H- tetrazol-5- yl)benzenesulfonamide::US9708336, 652 Metallo-beta-lactamase type 2 167 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262799 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262799&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266518 376224623 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497554 CC1(O)CCN(CC1)c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)C(F)(F)F InChI=1S/C14H17F3N6O3S/c1-13(24)4-6-23(7-5-13)9-3-2-8(14(15,16)17)11(27(18,25)26)10(9)12-19-21-22-20-12/h2-3,24H,4-7H2,1H3,(H2,18,25,26)(H,19,20,21,22) YFAPOSGUDKETPR-UHFFFAOYSA-N 262800 3-(4-hydroxy-4-methypiperidin-1- yl)-2-(1H-tetrazol-5-yl)-6- (trifluoromethyl)benzenesulfonamide::US9708336, 653 Metallo-beta-lactamase type 2 4.82 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262800 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262800&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266377 376224624 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497557 CC1(O)CCCN(C1)c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)C(F)(F)F 262801 3-(3-hydroxy-3-methylpiperidin-1- yl)-2-(1H-tetrazol-5-yl)-6- (trifluoromethyl)benzenesulfonamide::US9708336, 654 Metallo-beta-lactamase type 2 19.6 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262801 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262801&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266339 376224625 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497560 Cc1n[nH]c2CCN(Cc12)c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)C(F)(F)F InChI=1S/C15H15F3N8O2S/c1-7-8-6-26(5-4-10(8)21-20-7)11-3-2-9(15(16,17)18)13(29(19,27)28)12(11)14-22-24-25-23-14/h2-3H,4-6H2,1H3,(H,20,21)(H2,19,27,28)(H,22,23,24,25) CYRMEVWUFYIIFZ-UHFFFAOYSA-N 262802 3-(3-methyl-1,4,6,7-tetrahydro-5H- pyrazolo[4,3-c]pyridin-5-yl)-2-(1H- tetrazol-5-yl)-6- trifluoromethyl)benzenesulfonamide::US9708336, 655 Metallo-beta-lactamase type 2 7.80 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262802 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262802&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266340 376224626 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497563 NC(=O)C1CCN(CC1)c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)C(F)(F)F InChI=1S/C14H16F3N7O3S/c15-14(16,17)8-1-2-9(24-5-3-7(4-6-24)12(18)25)10(11(8)28(19,26)27)13-20-22-23-21-13/h1-2,7H,3-6H2,(H2,18,25)(H2,19,26,27)(H,20,21,22,23) FSJGEYSGSIWRMB-UHFFFAOYSA-N 262803 1-[3-sulfamoyl-2-(1H-tetrazol-5-yl)- 4-(trifluoromethyl)phenyl]piperidine- 4-carboxamide::US9708336, 656 Metallo-beta-lactamase type 2 2.84 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262803 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262803&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266360 376224627 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497566 NS(=O)(=O)c1c(ccc(N2CCC[C@H](O)C2)c1-c1nnn[nH]1)C(F)(F)F 262804 3-[(3S)-3-hydroxypiperidin-1-yl]-2- (1H-tetrazol-5-yl)-6- (trifluoromethyl)benzenesulfonamide::US9708336, 657 Metallo-beta-lactamase type 2 10.2 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262804 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262804&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266362 376224628 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497569 NS(=O)(=O)c1c(ccc(N2CC3C(CO)C3C2)c1-c1nnn[nH]1)C(F)(F)F 262805 3-[6-(hydroxymethyl)-3- azabicyclo[3.1.0]hex-3-yl]-2-(1H- tetrazol-5-yl)-6- (trifluoromethyl)benzenesulfonamide::US9708336, 658 Metallo-beta-lactamase type 2 7.00 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262805 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262805&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266364 376224629 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497572 NS(=O)(=O)c1c(ccc(N2CCCC(CO)C2)c1-c1nnn[nH]1)C(F)(F)F 262806 3-[3-(hydroxymethyl)piperidin-1-yl]- 2-(1H-tetrazol-5-yl)-6- (trifluoromethyl)benzenesulfonamide::US9708336, 659 Metallo-beta-lactamase type 2 36.3 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262806 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262806&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266534 376224630 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497575 NS(=O)(=O)c1c(ccc(N2CCCC(CCO)C2)c1-c1nnn[nH]1)C(F)(F)F 262807 3-[3-(2-hydroxyethyl)piperidin-1-yl]- 2-(1H-tetrazol-5-yl)-6- (trifluoromethyl)benzenesulfonamide::US9708336, 660 Metallo-beta-lactamase type 2 10.4 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262807 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262807&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266532 376224631 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497578 NS(=O)(=O)c1c(ccc(N2CCC(CCO)CC2)c1-c1nnn[nH]1)C(F)(F)F InChI=1S/C15H19F3N6O3S/c16-15(17,18)10-1-2-11(24-6-3-9(4-7-24)5-8-25)12(13(10)28(19,26)27)14-20-22-23-21-14/h1-2,9,25H,3-8H2,(H2,19,26,27)(H,20,21,22,23) DGYNHLCPOVDSJN-UHFFFAOYSA-N 262808 3-[4-(2-hydroxyethyl)piperidin-1-yl]- 2-(1H-tetrazol-5-yl)-6- (trifluoromethyl)benzenesulfonamide::US9708336, 661 Metallo-beta-lactamase type 2 0.965 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262808 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262808&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266535 376224632 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497581 NC(=O)C1CCCN(C1)c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)C(F)(F)F 262809 1-[3-sulfamoyl-2-(1H-tetrazol-5-yl)- 4-(trifluoromethyl)phenyl]piperidine- 3-carboxamide::US9708336, 662 Metallo-beta-lactamase type 2 37.1 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262809 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262809&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266464 376224633 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497584 NS(=O)(=O)c1c(ccc(N2CC[C@H](CO)[C@H](F)C2)c1-c1nnn[nH]1)C(F)(F)F 262810 3-[(3S,4R)-3-fluoro-4- (hydroxymethyl)piperidin-1-yl]-2- (1H-tetrazol-5-yl)-6- (trifluoromethyl)benzenesulfonamide::US9708336, 663 Metallo-beta-lactamase type 2 2.94 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262810 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262810&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266456 376224634 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497587 NS(=O)(=O)c1c(ccc(N2CCN(CCCO)CC2)c1-c1nnn[nH]1)C(F)(F)F InChI=1S/C15H20F3N7O3S/c16-15(17,18)10-2-3-11(25-7-5-24(6-8-25)4-1-9-26)12(13(10)29(19,27)28)14-20-22-23-21-14/h2-3,26H,1,4-9H2,(H2,19,27,28)(H,20,21,22,23) XVYDFDFRXDWKLC-UHFFFAOYSA-N 262811 3-[4-(3-hydroxypropyl)piperazin-1- yl]-2-(1H-tetrazol-5-yl)-6- (trifluoromethyl)benzenesulfonamide::US9708336, 664::US9708336, 763 Metallo-beta-lactamase type 2 38.5 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262811 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262811&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266047 376224635 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497590 NS(=O)(=O)c1c(ccc(N2CCC[C@@H](O)C2)c1-c1nnn[nH]1)C(F)(F)F 262812 3-[(3R)-3-hydroxypiperidin-1-yl]-2- (1H-tetrazol-5-yl)-6- (trifluoromethyl)benzenesulfonamide::US9708336, 665 Metallo-beta-lactamase type 2 29.8 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262812 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262812&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266277 376224636 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497593 NS(=O)(=O)c1c(ccc(N2C[C@H](O)C[C@@H](O)C2)c1-c1nnn[nH]1)C(F)(F)F 262813 3-[(3R,5R)-3,5-dihydroxypiperidin-1- yl]-2-(1H-tetrazol-5-yl)-6- (trifluoromethyl)benzenesulfonamide::US9708336, 666 Metallo-beta-lactamase type 2 150 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262813 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262813&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266306 376224637 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496033 NS(=O)(=O)c1cccc(C#CCN2CCC(=O)CC2)c1-c1nn[nH]n1 InChI=1S/C15H16N6O3S/c16-25(23,24)13-5-1-3-11(14(13)15-17-19-20-18-15)4-2-8-21-9-6-12(22)7-10-21/h1,3,5H,6-10H2,(H2,16,23,24)(H,17,18,19,20) MGUGCOBTHHJKIJ-UHFFFAOYSA-N 262294 3-[3-(4-oxopiperidin-1- yl)prop-1-yn-1-yl]-2-(2H- tetrazol-5- yl)benzenesulfonamide::US9708336, 146 Metallo-beta-lactamase type 2 766 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262294 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262294&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118265405 376224122 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496036 NS(=O)(=O)c1cccc(C#Cc2cccnc2)c1-c1nn[nH]n1 InChI=1S/C14H10N6O2S/c15-23(21,22)12-5-1-4-11(13(12)14-17-19-20-18-14)7-6-10-3-2-8-16-9-10/h1-5,8-9H,(H2,15,21,22)(H,17,18,19,20) GLDLQXBVVPHLOV-UHFFFAOYSA-N 262295 3-(pyridin-3-ylethynyl)-2- (2H-tetrazol-5- yl)benzenesulfonamide::US9708336, 147 Metallo-beta-lactamase type 2 103 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262295 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262295&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266088 376224123 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496039 NS(=O)(=O)c1cccc(C#CCN2CCS(=O)(=O)CC2)c1-c1nn[nH]n1 InChI=1S/C14H16N6O4S2/c15-26(23,24)12-5-1-3-11(13(12)14-16-18-19-17-14)4-2-6-20-7-9-25(21,22)10-8-20/h1,3,5H,6-10H2,(H2,15,23,24)(H,16,17,18,19) QGAXQOPGATXTSS-UHFFFAOYSA-N 262296 3-[3-(1,1- dioxidothiomorpholin-4- yl)prop-1-yn-1-yl]-2-(2H- tetrazol-5- yl)benzenesulfonamide::US9708336, 148 Metallo-beta-lactamase type 2 550 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262296 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262296&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266090 376224124 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496042 NS(=O)(=O)c1cccc(C2CCC2)c1-c1nnn[nH]1 InChI=1S/C11H13N5O2S/c12-19(17,18)9-6-2-5-8(7-3-1-4-7)10(9)11-13-15-16-14-11/h2,5-7H,1,3-4H2,(H2,12,17,18)(H,13,14,15,16) IXZVJBQADSTIQK-UHFFFAOYSA-N 262297 3-cyclobutyl-2-(1H-tetrazol- 5-yl)benzenesulfonamide::US9708336, 149 Metallo-beta-lactamase type 2 493 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262297 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262297&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266091 376224125 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496045 Cc1cccc(c1-c1nnn[nH]1)S(N)(=O)=O InChI=1S/C8H9N5O2S/c1-5-3-2-4-6(16(9,14)15)7(5)8-10-12-13-11-8/h2-4H,1H3,(H2,9,14,15)(H,10,11,12,13) BFGLWRZOTIJUEA-UHFFFAOYSA-N 262298 3-methyl-2-(1H-tetrazol-5- yl)benzenesulfonamide::US9708336, 150 Metallo-beta-lactamase type 2 1940 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262298 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262298&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 19832763 376224126 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496048 NS(=O)(=O)c1cccc(C2CCCCC2)c1-c1nnn[nH]1 InChI=1S/C13H17N5O2S/c14-21(19,20)11-8-4-7-10(9-5-2-1-3-6-9)12(11)13-15-17-18-16-13/h4,7-9H,1-3,5-6H2,(H2,14,19,20)(H,15,16,17,18) PZLPWHPGIDTPGB-UHFFFAOYSA-N 262299 3-cyclohexyl-2-(1H- tetrazol-5- yl)benzenesulfonamide::US9708336, 151 Metallo-beta-lactamase type 2 31.8 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262299 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262299&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266126 376224127 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496051 NS(=O)(=O)c1cccc(Cc2cccc(c2)C#N)c1-c1nnn[nH]1 InChI=1S/C15H12N6O2S/c16-9-11-4-1-3-10(7-11)8-12-5-2-6-13(24(17,22)23)14(12)15-18-20-21-19-15/h1-7H,8H2,(H2,17,22,23)(H,18,19,20,21) UFWPWKIAVUPDBT-UHFFFAOYSA-N 262300 3-(3-cyanobenzyl)-2-(1H- tetrazol-5- yl)benzenesulfonamide::US9708336, 152 Metallo-beta-lactamase type 2 252 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262300 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262300&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823545 376224128 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496054 NS(=O)(=O)c1cccc(CC2CCCCC2)c1-c1nnn[nH]1 InChI=1S/C14H19N5O2S/c15-22(20,21)12-8-4-7-11(9-10-5-2-1-3-6-10)13(12)14-16-18-19-17-14/h4,7-8,10H,1-3,5-6,9H2,(H2,15,20,21)(H,16,17,18,19) GXZCRJCMTKCCJH-UHFFFAOYSA-N 262301 3-(cyclohexylmethyl)-2- (1H-tetrazol-5- yl)benzenesulfonamide::US9708336, 153 Metallo-beta-lactamase type 2 71.3 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262301 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262301&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266086 376224129 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496057 NS(=O)(=O)c1cccc(CCc2ccccc2)c1-c1nnn[nH]1 InChI=1S/C15H15N5O2S/c16-23(21,22)13-8-4-7-12(14(13)15-17-19-20-18-15)10-9-11-5-2-1-3-6-11/h1-8H,9-10H2,(H2,16,21,22)(H,17,18,19,20) XFGXYXRVMYDSIT-UHFFFAOYSA-N 262302 3-phenethyl-2-(1H-tetrazol- 5-yl)benzenesulfonamide::US9708336, 154 Metallo-beta-lactamase type 2 10.8 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262302 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262302&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823546 376224130 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496060 Cc1ccccc1Cc1cccc(c1-c1nnn[nH]1)S(N)(=O)=O InChI=1S/C15H15N5O2S/c1-10-5-2-3-6-11(10)9-12-7-4-8-13(23(16,21)22)14(12)15-17-19-20-18-15/h2-8H,9H2,1H3,(H2,16,21,22)(H,17,18,19,20) WRMJKZNMRNYIGW-UHFFFAOYSA-N 262303 3-(2-methylbenzyl)-2-(1H- tetrazol-5- yl)benzenesulfonamide::US9708336, 155 Metallo-beta-lactamase type 2 92.7 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262303 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262303&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823547 376224131 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496063 CC(C)c1cccc(c1-c1nnn[nH]1)S(N)(=O)=O InChI=1S/C10H13N5O2S/c1-6(2)7-4-3-5-8(18(11,16)17)9(7)10-12-14-15-13-10/h3-6H,1-2H3,(H2,11,16,17)(H,12,13,14,15) YYOOWUBXEFBUCM-UHFFFAOYSA-N 262304 3-isopropyl-2-(1H-tetrazol- 5-yl)benzenesulfonamide::US9708336, 156 Metallo-beta-lactamase type 2 508 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262304 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262304&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266061 376224132 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496066 NS(=O)(=O)c1cccc(C2CC2)c1-c1nnn[nH]1 InChI=1S/C10H11N5O2S/c11-18(16,17)8-3-1-2-7(6-4-5-6)9(8)10-12-14-15-13-10/h1-3,6H,4-5H2,(H2,11,16,17)(H,12,13,14,15) CHTFTYWJKSKNNK-UHFFFAOYSA-N 262305 3-cyclopropyl-2-(1H- tetrazol-5- yl)benzenesulfonamide::US9708336, 157 Metallo-beta-lactamase type 2 561 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262305 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262305&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266096 376224133 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496069 Cc1cccc(Cc2cccc(c2-c2nnn[nH]2)S(N)(=O)=O)c1 InChI=1S/C15H15N5O2S/c1-10-4-2-5-11(8-10)9-12-6-3-7-13(23(16,21)22)14(12)15-17-19-20-18-15/h2-8H,9H2,1H3,(H2,16,21,22)(H,17,18,19,20) NDBSRCOVEAKOPX-UHFFFAOYSA-N 262306 3-(3-methylbenzyl)-2-(1H- tetrazol-5- yl)benzenesulfonamide::US9708336, 158 Metallo-beta-lactamase type 2 387 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262306 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262306&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823548 376224134 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496072 CC(C)(C)Cc1cccc(c1-c1nnn[nH]1)S(N)(=O)=O InChI=1S/C12H17N5O2S/c1-12(2,3)7-8-5-4-6-9(20(13,18)19)10(8)11-14-16-17-15-11/h4-6H,7H2,1-3H3,(H2,13,18,19)(H,14,15,16,17) MWIUUVQQBKOPOE-UHFFFAOYSA-N 262307 3-neopentyl-2-(1H-tetrazol- 5-yl)benzenesulfonamide::US9708336, 159 Metallo-beta-lactamase type 2 526 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262307 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262307&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266135 376224135 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496075 NS(=O)(=O)c1cccc(C2CCCC2)c1-c1nnn[nH]1 InChI=1S/C12H15N5O2S/c13-20(18,19)10-7-3-6-9(8-4-1-2-5-8)11(10)12-14-16-17-15-12/h3,6-8H,1-2,4-5H2,(H2,13,18,19)(H,14,15,16,17) IUHZNBIUIYIBGV-UHFFFAOYSA-N 262308 3-cyclopentyl-2-(1H- tetrazol-5- yl)benzenesulfonamide::US9708336, 160 Metallo-beta-lactamase type 2 251 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262308 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262308&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266098 376224136 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496078 CC(C)(C)c1cccc(c1-c1nnn[nH]1)S(N)(=O)=O InChI=1S/C11H15N5O2S/c1-11(2,3)7-5-4-6-8(19(12,17)18)9(7)10-13-15-16-14-10/h4-6H,1-3H3,(H2,12,17,18)(H,13,14,15,16) UQJYCVVIARVJPG-UHFFFAOYSA-N 262309 3-(tert-butyl)-2-(1H- tetrazol-5- yl)benzenesulfonamide::US9708336, 161 Metallo-beta-lactamase type 2 306 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262309 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262309&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266117 376224137 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496081 NS(=O)(=O)c1cccc(Cc2ccccc2)c1-c1nnn[nH]1 InChI=1S/C14H13N5O2S/c15-22(20,21)12-8-4-7-11(9-10-5-2-1-3-6-10)13(12)14-16-18-19-17-14/h1-8H,9H2,(H2,15,20,21)(H,16,17,18,19) SYNBRCXHHHHBQW-UHFFFAOYSA-N 262310 3-benzyl-2-(1H-tetrazol-5- yl)benzenesulfonamide::US9708336, 162 Metallo-beta-lactamase type 2 571 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262310 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262310&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823549 376224138 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496084 Cc1ccc(Cc2cccc(c2-c2nnn[nH]2)S(N)(=O)=O)cc1 InChI=1S/C15H15N5O2S/c1-10-5-7-11(8-6-10)9-12-3-2-4-13(23(16,21)22)14(12)15-17-19-20-18-15/h2-8H,9H2,1H3,(H2,16,21,22)(H,17,18,19,20) FLVXOJJEZOFFAW-UHFFFAOYSA-N 262311 3-(4-methylbenzyl)-2-(1H- tetrazol-5- yl)benzenesulfonamide::US9708336, 163 Metallo-beta-lactamase type 2 327 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262311 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262311&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823550 376224139 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496087 NS(=O)(=O)c1cccc(CCC2CCCCC2)c1-c1nnn[nH]1 InChI=1S/C15H21N5O2S/c16-23(21,22)13-8-4-7-12(14(13)15-17-19-20-18-15)10-9-11-5-2-1-3-6-11/h4,7-8,11H,1-3,5-6,9-10H2,(H2,16,21,22)(H,17,18,19,20) MKORSCOCXZMSFI-UHFFFAOYSA-N 262312 3-(2-cyclohexylethyl)-2- (1H-tetrazol-5- yl)benzenesulfonamide::US9708336, 164 Metallo-beta-lactamase type 2 5.50 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262312 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262312&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118265413 376224140 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496090 NS(=O)(=O)c1cccc(-c2cnc3ccccc3c2)c1-c1nnn[nH]1 InChI=1S/C16H12N6O2S/c17-25(23,24)14-7-3-5-12(15(14)16-19-21-22-20-16)11-8-10-4-1-2-6-13(10)18-9-11/h1-9H,(H2,17,23,24)(H,19,20,21,22) SOODWLJDZSLPID-UHFFFAOYSA-N 262313 3-(quinolin-3-yl)-2-(1H- tetrazol-5- yl)benzenesulfonamide::US9708336, 165 Metallo-beta-lactamase type 2 214 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262313 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262313&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823551 376224141 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496093 NS(=O)(=O)c1cccc(Cc2ccccc2C#N)c1-c1nnn[nH]1 InChI=1S/C15H12N6O2S/c16-9-12-5-2-1-4-10(12)8-11-6-3-7-13(24(17,22)23)14(11)15-18-20-21-19-15/h1-7H,8H2,(H2,17,22,23)(H,18,19,20,21) YWQCJYSXRHQJDT-UHFFFAOYSA-N 262314 3-(2-cyanobenzyl)-2-(1H- tetrazol-5- yl)benzenesulfonamide::US9708336, 166 Metallo-beta-lactamase type 2 74.5 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262314 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262314&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823552 376224142 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496096 CC(C)Cc1cccc(c1-c1nn[nH]n1)S(N)(=O)=O InChI=1S/C11H15N5O2S/c1-7(2)6-8-4-3-5-9(19(12,17)18)10(8)11-13-15-16-14-11/h3-5,7H,6H2,1-2H3,(H2,12,17,18)(H,13,14,15,16) XRCDZUPCWBYRDY-UHFFFAOYSA-N 262315 3-isobutyl-2-(2H-tetrazol-5-yl)benzenesulfonamide::US9708336, 167 Metallo-beta-lactamase type 2 260 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262315 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262315&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118256979 376224143 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497074 NS(=O)(=O)c1c(ccc(C2CCC2)c1-c1nnn[nH]1)C(F)(F)F InChI=1S/C12H12F3N5O2S/c13-12(14,15)8-5-4-7(6-2-1-3-6)9(10(8)23(16,21)22)11-17-19-20-18-11/h4-6H,1-3H2,(H2,16,21,22)(H,17,18,19,20) UTUFHASKLWJMEB-UHFFFAOYSA-N 262640 3-cyclobutyl-2-(1H-tetrazol-5-yl)-6- (trifluoromethyl)benzenesulfonamide::US9708336, 492 Metallo-beta-lactamase type 2 16.0 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262640 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262640&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266681 376224465 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497077 NS(=O)(=O)c1c(ccc(C2CCNc3ccccc23)c1-c1nnn[nH]1)C(F)(F)F 262641 3-(1,2,3,4-Tetrahydroquinolin-4-yl)-2-(1H-tetrazol-5-yl)-6-(trifluoromethyl)benzenesulfonamide::US9708336, 493 Metallo-beta-lactamase type 2 4.50 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262641 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262641&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823637 376224466 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497080 NS(=O)(=O)c1c(ccc(C2CCn3cncc3C2)c1-c1nnn[nH]1)C(F)(F)F 262642 3-(5,6,7,8-Tetrahydroimidazo[1,5-a]pyridin-7-yl)-2-(1H-tetrazol-5-yl)-6-(trifluoromethyl)benzenesulfonamide::US9708336, 494 Metallo-beta-lactamase type 2 13.0 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262642 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262642&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823638 376224467 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497083 NS(=O)(=O)c1c(ccc(C2CC[C@H](O)CC2)c1-c1nnn[nH]1)C(F)(F)F 262643 3-((cis 4-hydroxycyclohexyl)-2-(1H-tetrazol-5-yl)-6-(trifluoromethyl)benzenesulfonamide::US9708336, 495 Metallo-beta-lactamase type 2 4.26 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262643 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262643&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266650 376224468 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497086 NS(=O)(=O)c1c(ccc(C2CC[C@H](O)CC2)c1-c1nnn[nH]1)C(F)(F)F 262644 3-((trans 4-hydroxycyclohexyl)-2-(1H-tetrazol-5-yl)-6-(trifluoromethyl)benzenesulfonamide::US9708336, 496 Metallo-beta-lactamase type 2 1.09 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262644 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262644&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266650 376224469 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497089 NCC1(N)CCC(CC1)c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)C(F)(F)F InChI=1S/C15H20F3N7O2S/c16-15(17,18)10-2-1-9(8-3-5-14(20,7-19)6-4-8)11(12(10)28(21,26)27)13-22-24-25-23-13/h1-2,8H,3-7,19-20H2,(H2,21,26,27)(H,22,23,24,25) CDBWIHADXOVZTK-UHFFFAOYSA-N 262645 3-(4-Amino-4-(aminomethyl)cyclohexyl)-2-(1H-tetrazol-5-yl)-6-(trifluoromethyl)benzenesulfonamide::US9708336, 497 Metallo-beta-lactamase type 2 25.8 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262645 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262645&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118257076 376224470 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497092 NCC[C@H]1CCC(CC1)c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)C(F)(F)F 262646 3-(cis 4-(2-aminoethyl)cyclohexyl)-2-(1H-tetrazol-5-yl)-6-(trifluoromethyl)benzenesulfonamide::US9708336, 498 Metallo-beta-lactamase type 2 5.50 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262646 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262646&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118257304 376224471 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497095 NCC[C@H]1CCC(CC1)c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)C(F)(F)F 262647 3-(trans 4-(2-aminoethyl)cyclohexyl)-2-(1H-tetrazol-5-yl)-6-(trifluoromethyl)benzenesulfonamide::US9708336, 499 Metallo-beta-lactamase type 2 7.04 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262647 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262647&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118257304 376224472 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497098 NC[C@H]1CC[C@@H](CC1)c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)C(F)(F)F 262648 3-(cis 4-(Aminomethyl)cyclohexyl)-2-(1H-tetrazol-5-yl)-6-(trifluoromethyl)benzenesulfonamide::US9708336, 500 Metallo-beta-lactamase type 2 9.86 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262648 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262648&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118257183 376224473 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497101 NC[C@H]1CC[C@H](CC1)c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)C(F)(F)F 262649 3-(trans 4-(aminomethyl)cyclohexyl)-2-(1H-tetrazol-5-yl)-6-(trifluoromethyl)benzenesulfonamide::US9708336, 501 Metallo-beta-lactamase type 2 5.39 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262649 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262649&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118257183 376224474 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497104 NC(=N)NC[C@H]1CCC(CC1)c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)C(F)(F)F 262650 3-(cis 4-(guanidinomethyl)cyclohexyl)-2-(1H-tetrazol-5-yl)-6-(trifluoromethyl)benzenesulfonamide and 3-(trans 4-(guanidinomethyl)cyclohexyl)-2-(1H-tetrazol-5-yl)-6-(trifluoromethyl)benzenesulfonamide::US9708336, 502 Metallo-beta-lactamase type 2 1.19 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262650 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262650&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118256867 376224475 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497107 NC(=N)NC[C@H]1CCC(CC1)c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)C(F)(F)F 262651 US9708336, 503 Metallo-beta-lactamase type 2 4.20 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262651 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262651&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118256867 376224476 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497110 NS(=O)(=O)c1c(ccc([C@@H]2CC[C@@H](CC2)C2=NCCN2)c1-c1nnn[nH]1)C(F)(F)F 262652 3-(cis 4-(4,5-dihydro-1H-imidazol-2-yl)cyclohexyl)-2-(1H-tetrazol-5-yl)-6-(trifluoromethyl)benzenesulfonamide::US9708336, 505 Metallo-beta-lactamase type 2 22.2 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262652 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262652&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118257360 376224477 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497113 NS(=O)(=O)c1c(ccc([C@H]2CC[C@@H](CC2)C2=NCCN2)c1-c1nnn[nH]1)C(F)(F)F 262653 3-(trans 4-(4,5-dihydro-1H-imidazol-2-yl)cyclohexyl)-2-(1H-tetrazol-5-yl)-6-(trifluoromethyl)benzenesulfonamide::US9708336, 506 Metallo-beta-lactamase type 2 35.7 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262653 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262653&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118257360 376224478 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497116 Nc1ncc(cc1CO)C#Cc1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)C(F)(F)F InChI=1S/C16H12F3N7O3S/c17-16(18,19)11-4-3-9(2-1-8-5-10(7-27)14(20)22-6-8)12(13(11)30(21,28)29)15-23-25-26-24-15/h3-6,27H,7H2,(H2,20,22)(H2,21,28,29)(H,23,24,25,26) RFBOCACISXANCN-UHFFFAOYSA-N 262654 3-((6-Amino-5-(hydroxymethyl)pyridin-3-yl)ethynyl)-2-(2H-tetrazol-5-yl)-6-(trifluoromethyl)benzenesulfonamide::US9708336, 507 Metallo-beta-lactamase type 2 4.31 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262654 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262654&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118256908 376224479 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497119 Nc1ncc(CCc2ccc(c(c2-c2nn[nH]n2)S(N)(=O)=O)C(F)(F)F)cc1CO InChI=1S/C16H16F3N7O3S/c17-16(18,19)11-4-3-9(2-1-8-5-10(7-27)14(20)22-6-8)12(13(11)30(21,28)29)15-23-25-26-24-15/h3-6,27H,1-2,7H2,(H2,20,22)(H2,21,28,29)(H,23,24,25,26) XPLPTEAFUXIQGB-UHFFFAOYSA-N 262655 3-(2-(6-Amino-5-(hydroxymethyl)pyridin-3-yl)ethyl)-2-(2H-tetrazol-5-yl)-6-(trifluoromethyl)benzenesulfonamide::US9708336, 508 Metallo-beta-lactamase type 2 2.37 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262655 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262655&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118257027 376224480 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497122 NCC(CN)c1ccc(cc1)-c1cccc(c1-c1nnn[nH]1)S(N)(=O)=O InChI=1S/C16H19N7O2S/c17-8-12(9-18)10-4-6-11(7-5-10)13-2-1-3-14(26(19,24)25)15(13)16-20-22-23-21-16/h1-7,12H,8-9,17-18H2,(H2,19,24,25)(H,20,21,22,23) WDBNHJWTVXCZCS-UHFFFAOYSA-N 262656 4′-(1,3-Diaminopropan-2-yl)-2-(1H-tetrazol-5-yl)-[1,1′-biphenyl]-3-sulfonamide::US9708336, 509 Metallo-beta-lactamase type 2 929 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262656 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262656&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118257254 376224481 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497125 NS(=O)(=O)c1c(ccc(C2CCCc3sc(nc23)C(O)=O)c1-c1nnn[nH]1)C(F)(F)F 262657 4-(3-Sulfamoyl-2-(1H-tetrazol-5-yl)-4-(trifluoromethyl)phenyl)-4,5,6,7-tetrahydrobenzo[d]thiazole-2-carboxylic acid::US9708336, 510 Metallo-beta-lactamase type 2 47.4 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262657 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262657&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266513 376224482 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497128 NC1=NCC(CN1)c1ccc(cc1)-c1cccc(c1-c1nnn[nH]1)S(N)(=O)=O 262658 4′-(2-Amino-1,4,5,6-tetrahydropyrimidin-5-yl)-2-(1H-tetrazol-5-yl)-[1,1′-biphenyl]-3-sulfonamide::US9708336, 511 Metallo-beta-lactamase type 2 14.3 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262658 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262658&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266253 376224483 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497131 COCc1cc(CCc2ccc(c(c2-c2nn[nH]n2)S(N)(=O)=O)C(F)(F)F)cnc1N InChI=1S/C17H18F3N7O3S/c1-30-8-11-6-9(7-23-15(11)21)2-3-10-4-5-12(17(18,19)20)14(31(22,28)29)13(10)16-24-26-27-25-16/h4-7H,2-3,8H2,1H3,(H2,21,23)(H2,22,28,29)(H,24,25,26,27) FHJHKKHYAIIXQM-UHFFFAOYSA-N 262659 3-(2-(6-Amino-5- (methoxymethyl)pyridin-3-yl)ethyl)- 2-(2H-tetrazol-5-yl)-6- (trifluoromethyl)benzenesulfonamide::US9708336, 512 Metallo-beta-lactamase type 2 46.0 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262659 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262659&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823639 376224484 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497134 NCc1ncc(CCc2ccc(c(c2-c2nn[nH]n2)S(N)(=O)=O)C(F)(F)F)cc1N InChI=1S/C16H17F3N8O2S/c17-16(18,19)10-4-3-9(2-1-8-5-11(21)12(6-20)23-7-8)13(14(10)30(22,28)29)15-24-26-27-25-15/h3-5,7H,1-2,6,20-21H2,(H2,22,28,29)(H,24,25,26,27) YNDTVXVGDJXRPL-UHFFFAOYSA-N 262660 3-(2-(5-Amino-6- (aminomethyl)pyridin-3-yl)ethyl)-2- (2H-tetrazol-5-yl)-6- (trifluoromethyl)benzenesulfonamide::US9708336, 513 Metallo-beta-lactamase type 2 3.61 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262660 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262660&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823640 376224485 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497596 NS(=O)(=O)c1c(ccc(N2CCN3C(COC3=O)C2)c1-c1nnn[nH]1)C(F)(F)F 262814 3-(3-oxotetrahydro[1,3]oxazolo[3,4- a]pyrazin-7(1H)-yl)-2-(1H-tetrazol-5- yl)-6- (trifluoromethyl)benzenesulfonamide::US9708336, 667 Metallo-beta-lactamase type 2 75.0 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262814 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262814&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266267 376224638 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497599 NS(=O)(=O)c1c(ccc(-c2ccc(cc2)C2CCN(CC3CCNCC3)CC2)c1-c1nnn[nH]1)C(F)(F)F InChI=1S/C25H30F3N7O2S/c26-25(27,28)21-6-5-20(22(23(21)38(29,36)37)24-31-33-34-32-24)19-3-1-17(2-4-19)18-9-13-35(14-10-18)15-16-7-11-30-12-8-16/h1-6,16,18,30H,7-15H2,(H2,29,36,37)(H,31,32,33,34) SWNFLOUOCBKJKZ-UHFFFAOYSA-N 262815 4'-[1-(piperidin-4- ylmethyl)piperidin-4-yl]- 2-(1H-tetrazol-5-yl)-4- (trifluoromethyl)biphenyl- 3-sulfonamide::US9708336, 668 Metallo-beta-lactamase type 2 2.80 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262815 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262815&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266446 376224639 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497602 NS(=O)(=O)c1c(ccc(-c2ccc(cc2)C2CCN(C[C@@H]3CCCN3)CC2)c1-c1nnn[nH]1)C(F)(F)F 262816 4'-{1-[(2S)-pyrrolidin-2- ylmethyl]piperidin-4-yl}- 2-(1H-tetrazol-5-yl)-4- (trifluoromethyl)biphenyl- 3-sulfonamide::US9708336, 669 Metallo-beta-lactamase type 2 0.688 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262816 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262816&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266469 376224640 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497605 NS(=O)(=O)c1c(ccc(-c2ccc(cc2)C2CCN(C[C@H]3CNCCO3)CC2)c1-c1nnn[nH]1)C(F)(F)F 262817 4'-{1-[(2R)-morpholin-2- ylmethyl]piperidin-4-yl}- 2-(1H-tetrazol-5-yl)-4- (trifluoromethyl)biphenyl- 3-sulfonamide::US9708336, 670 Metallo-beta-lactamase type 2 1.08 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262817 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262817&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266470 376224641 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497608 NS(=O)(=O)c1c(ccc(-c2ccc(cc2)C2CCN(CC3CNC3)CC2)c1-c1nnn[nH]1)C(F)(F)F InChI=1S/C23H26F3N7O2S/c24-23(25,26)19-6-5-18(20(21(19)36(27,34)35)22-29-31-32-30-22)17-3-1-15(2-4-17)16-7-9-33(10-8-16)13-14-11-28-12-14/h1-6,14,16,28H,7-13H2,(H2,27,34,35)(H,29,30,31,32) OASRXZZSPMUCKN-UHFFFAOYSA-N 262818 4'-[1-(azetidin-3- ylmethyl)piperidin-4-yl]- 2-(1H-tetrazol-5-yl)-4- (trifluoromethyl)biphenyl- 3-sulfonamide::US9708336, 671 Metallo-beta-lactamase type 2 2.00 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262818 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262818&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266447 376224642 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497611 NC1(CN2CCC(CC2)c2ccc(cc2)-c2ccc(c(c2-c2nnn[nH]2)S(N)(=O)=O)C(F)(F)F)CC1 InChI=1S/C23H26F3N7O2S/c24-23(25,26)18-6-5-17(19(20(18)36(28,34)35)21-29-31-32-30-21)16-3-1-14(2-4-16)15-7-11-33(12-8-15)13-22(27)9-10-22/h1-6,15H,7-13,27H2,(H2,28,34,35)(H,29,30,31,32) VIWDEKVIIKABHL-UHFFFAOYSA-N 262819 4'-{1-[(1- aminocyclopropyl)methyl] piperidin-4-yl}-2-(1H- tetrazol-5-yl)-4- (trifluoromethyl)biphenyl- 3-sulfonamide::US9708336, 672 Metallo-beta-lactamase type 2 2.51 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262819 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262819&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266448 376224643 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497614 NS(=O)(=O)c1c(ccc(-c2ccc(cc2)C2CCN(CC3CCCNC3)CC2)c1-c1nnn[nH]1)C(F)(F)F 262820 4'-[1-(piperidin-3- ylmethyl)piperidin-4-yl]- 2-(1H-tetrazol-5-yl)-4- (trifluoromethyl)biphenyl- 3-sulfonamide::US9708336, 673 Metallo-beta-lactamase type 2 1.35 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262820 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262820&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266028 376224644 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497617 CNCCN1CCC(CC1)c1ccc(cc1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)C(F)(F)F InChI=1S/C22H26F3N7O2S/c1-27-10-13-32-11-8-15(9-12-32)14-2-4-16(5-3-14)17-6-7-18(22(23,24)25)20(35(26,33)34)19(17)21-28-30-31-29-21/h2-7,15,27H,8-13H2,1H3,(H2,26,33,34)(H,28,29,30,31) DQMFEWYAMSOZDH-UHFFFAOYSA-N 262821 4'-{1-[2- (methylamino)ethyl]piperi- din-4-yl}-2-(1H- tetrazol-5-yl)-4- (trifluoromethyl)biphenyl- 3-sulfonamide::US9708336, 674 Metallo-beta-lactamase type 2 2.47 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262821 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262821&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266027 376224645 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497620 NS(=O)(=O)c1c(ccc(-c2ccc(cc2)C2CCN(C[C@H]3CCCN3)CC2)c1-c1nnn[nH]1)C(F)(F)F 262822 4'-{1-[(2R)-pyrrolidin-2- ylmethyl]piperidin-4-yl}- 2-(1H-tetrazol-5-yl)-4- (trifluoromethyl)biphenyl- 3-sulfonamide::US9708336, 675 Metallo-beta-lactamase type 2 1.94 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262822 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262822&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266026 376224646 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497623 NS(=O)(=O)c1c(ccc(-c2ccc(cc2)C2CCN(CC3CCCCN3)CC2)c1-c1nnn[nH]1)C(F)(F)F 262823 4'-[1-(piperidin-2- ylmethyl)piperidin-4-yl]- 2-(1H-tetrazol-5-yl)-4- (trifluoromethyl)biphenyl- 3-sulfonamide::US9708336, 676 Metallo-beta-lactamase type 2 1.26 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262823 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262823&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266025 376224647 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497626 C[N+](C)(C)CCN1CCC(CC1)c1ccc(cc1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)C(F)(F)F InChI=1S/C24H31F3N7O2S/c1-34(2,3)15-14-33-12-10-17(11-13-33)16-4-6-18(7-5-16)19-8-9-20(24(25,26)27)22(37(28,35)36)21(19)23-29-31-32-30-23/h4-9,17H,10-15H2,1-3H3,(H2,28,35,36)(H,29,30,31,32)/q+1 UCKLRNHPKJTRDY-UHFFFAOYSA-N 262824 N,N,N-trimethyl-2-{4- [3'-sulfamoyl-2'-(1H- tetrazol-5-yl)-4'- (trifluoromethyl)biphenyl- 4-yl]piperidin-1- yl}ethanaminium::US9708336, 677 Metallo-beta-lactamase type 2 0.541 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262824 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262824&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266029 376224648 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497629 NS(=O)(=O)c1c(ccc(-c2ccc(cc2)C2CCN(C[C@@H]3CNCCO3)CC2)c1-c1nnn[nH]1)C(F)(F)F 262825 4'-{1-[(2S)-morpholin-2- ylmethyl]piperidin-4-yl}- 2-(1H-tetrazol-5-yl)-4- (trifluoromethyl)biphenyl- 3-sulfonamide::US9708336, 678 Metallo-beta-lactamase type 2 5.00 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262825 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262825&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266390 376224649 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497632 NS(=O)(=O)c1c(ccc([C@H]2CC[C@@H](CC2)NC2CC[C@H]3CCN[C@H]3C2)c1-c1nnn[nH]1)C(F)(F)F 262826 3-{4-[(3aS,6S,7aS)- octahydro-1H-indol-6- ylamino]cyclohexyl}-2- (1H-tetrazol-5-yl)-6- (trifluoromethyl)benzene sulfonamide::US9708336, 679 Metallo-beta-lactamase type 2 75.3 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262826 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262826&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266284 376224650 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497635 NS(=O)(=O)c1c(ccc([C@H]2CC[C@@H](CC2)NCC2CCNCC2)c1-c1nnn[nH]1)C(F)(F)F 262827 3-{4-[(piperidin-4- ylmethyl)amino]cyclohex- yl}-2-(1H-tetrazol-5-yl)-6- (trifluoromethyl)benzene sulfonamide::US9708336, 680 Metallo-beta-lactamase type 2 86.6 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262827 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262827&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266291 376224651 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497638 NS(=O)(=O)c1c(ccc([C@H]2CC[C@@H](CC2)NCC2CCCN2)c1-c1nnn[nH]1)C(F)(F)F 262828 3-{4-[(pyrrolidin-2- ylmethyl)amino]cyclohex- yl}-2-(1H-tetrazol-5-yl)-6- (trifluoromethyl)benzene sulfonamide::US9708336, 681 Metallo-beta-lactamase type 2 16.1 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262828 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262828&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266294 376224652 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497641 Nc1ccc(CN[C@H]2CCC(CC2)c2ccc(c(c2-c2nnn[nH]2)S(N)(=O)=O)C(F)(F)F)cn1 262829 3-(4-{[(6-aminopyridin-3- yl)methyl]amino}cyclohex- yl)-2-(1H-tetrazol-5-yl)- 6- (trifluoromethyl)benzene sulfonamide::US9708336, 682 Metallo-beta-lactamase type 2 27.4 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262829 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262829&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823678 376224653 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497644 CC(N[C@H]1CC[C@@H](CC1)c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)C(F)(F)F)C1CCNCC1 262830 3-{4-[(1-piperidin-4- ylethyl)amino]cyclohexyl}- 2-(1H-tetrazol-5-yl)-6- (trifluoromethyl)benzene sulfonamide::US9708336, 683 Metallo-beta-lactamase type 2 154 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262830 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262830&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266293 376224654 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497647 NS(=O)(=O)c1c(ccc([C@H]2CC[C@@H](CC2)NC2CC[C@@H]3CNCC[C@H]3C2)c1-c1nnn[nH]1)C(F)(F)F 262831 3-{4-[(4aS,8aS)- decahydroisoquinolin-6- ylamino]cyclohexyl}-2- (1H-tetrazol-5-yl)-6- (trifluoromethyl)benzene sulfonamide::US9708336, 684 Metallo-beta-lactamase type 2 75.7 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262831 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262831&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266300 376224655 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497650 NS(=O)(=O)c1c(ccc([C@H]2CC[C@@H](CC2)NC2CC3(C2)CCNCC3)c1-c1nnn[nH]1)C(F)(F)F 262832 3-[4-(7-azaspiro[3.5]non- 2-ylamino)cyclohexyl]-2- (1H-tetrazol-5-yl)-6- (trifluoromethyl)benzene sulfonamide::US9708336, 685 Metallo-beta-lactamase type 2 75.8 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262832 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262832&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266296 376224656 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497653 NS(=O)(=O)c1c(ccc([C@H]2CC[C@@H](CC2)NC2CC3CNCCN3C2)c1-c1nnn[nH]1)C(F)(F)F 262833 3-[4- (octahydropyrrolo[1,2- a]pyrazin-7- ylamino)cyclohexyl]-2- (1H-tetrazol-5-yl)-6- (trifluoromethyl)benzene sulfonamide::US9708336, 686 Metallo-beta-lactamase type 2 31.7 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262833 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262833&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266663 376224657 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497656 NC1CCCC(C1)N[C@H]1CCC(CC1)c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)C(F)(F)F 262834 3-{4-[(3- aminocyclohexyl)amino] cyclohexyl}-2-(1H- tetrazol-5-yl)-6- (trifluoromethyl)benzene sulfonamide::US9708336, 687 Metallo-beta-lactamase type 2 94.3 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262834 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262834&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266665 376224658 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496099 NC1CCC(CC1)c1cccc(c1-c1nn[nH]n1)S(N)(=O)=O InChI=1S/C13H18N6O2S/c14-9-6-4-8(5-7-9)10-2-1-3-11(22(15,20)21)12(10)13-16-18-19-17-13/h1-3,8-9H,4-7,14H2,(H2,15,20,21)(H,16,17,18,19) YUGFTEKIKIKVHC-UHFFFAOYSA-N 262316 3-(4-Aminocyclohexyl)-2-(2H-tetrazol-5-yl)benzenesulfonamide::US9708336, 168 Metallo-beta-lactamase type 2 865 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262316 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262316&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118257052 376224144 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496102 CS(=O)(=O)NC1CCC(CC1)c1cccc(c1-c1nn[nH]n1)S(N)(=O)=O InChI=1S/C14H20N6O4S2/c1-25(21,22)18-10-7-5-9(6-8-10)11-3-2-4-12(26(15,23)24)13(11)14-16-19-20-17-14/h2-4,9-10,18H,5-8H2,1H3,(H2,15,23,24)(H,16,17,19,20) DJLMLAPQHUJVTI-UHFFFAOYSA-N 262317 3-(4-(methylsulfonamido)cyclohexyl)-2-(2H-tetrazol-5-yl)benzenesulfonamide::US9708336, 169 Metallo-beta-lactamase type 2 111 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262317 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262317&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118257177 376224145 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496105 NS(=O)(=O)c1cccc(C2CCC(CC2)N2CCNCC2)c1-c1nn[nH]n1 InChI=1S/C17H25N7O2S/c18-27(25,26)15-3-1-2-14(16(15)17-20-22-23-21-17)12-4-6-13(7-5-12)24-10-8-19-9-11-24/h1-3,12-13,19H,4-11H2,(H2,18,25,26)(H,20,21,22,23) CXEFWGZCYZCESY-UHFFFAOYSA-N 262318 3-(4-(piperazin-1-yl)cyclohexyl)-2-(2H-tetrazol-5-yl)benzenesulfonamide::US9708336, 170 Metallo-beta-lactamase type 2 577 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262318 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262318&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118256804 376224146 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496108 NS(=O)(=O)c1cccc(C2CCC(O)CC2)c1-c1nn[nH]n1 InChI=1S/C13H17N5O3S/c14-22(20,21)11-3-1-2-10(8-4-6-9(19)7-5-8)12(11)13-15-17-18-16-13/h1-3,8-9,19H,4-7H2,(H2,14,20,21)(H,15,16,17,18) MCELTIBIHPACTD-UHFFFAOYSA-N 262319 3-(4-hydroxycyclohexyl)-2-(2H-tetrazol-5-yl)benzenesulfonamide::US9708336, 171 Metallo-beta-lactamase type 2 119 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262319 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262319&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118256773 376224147 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496111 CS(=O)(=O)N1CCC(CC1)c1cccc(c1-c1nn[nH]n1)S(N)(=O)=O InChI=1S/C13H18N6O4S2/c1-24(20,21)19-7-5-9(6-8-19)10-3-2-4-11(25(14,22)23)12(10)13-15-17-18-16-13/h2-4,9H,5-8H2,1H3,(H2,14,22,23)(H,15,16,17,18) NLRNRAODRDUWJY-UHFFFAOYSA-N 262320 3-(1-(methylsulfonyl)piperidin-4-yl)-2-(2H-tetrazol-5-yl)benzenesulfonamide::US9708336, 172 Metallo-beta-lactamase type 2 720 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262320 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262320&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118257066 376224148 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496114 CCOC(=O)N1CCC(CC1)c1cccc(c1-c1nn[nH]n1)S(N)(=O)=O InChI=1S/C15H20N6O4S/c1-2-25-15(22)21-8-6-10(7-9-21)11-4-3-5-12(26(16,23)24)13(11)14-17-19-20-18-14/h3-5,10H,2,6-9H2,1H3,(H2,16,23,24)(H,17,18,19,20) KLVKTQRYLXNNHS-UHFFFAOYSA-N 262321 US9708336, 173 Metallo-beta-lactamase type 2 149 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262321 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262321&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118256820 376224149 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496117 CCNC(=O)N1CCC(CC1)c1cccc(c1-c1nn[nH]n1)S(N)(=O)=O InChI=1S/C15H21N7O3S/c1-2-17-15(23)22-8-6-10(7-9-22)11-4-3-5-12(26(16,24)25)13(11)14-18-20-21-19-14/h3-5,10H,2,6-9H2,1H3,(H,17,23)(H2,16,24,25)(H,18,19,20,21) IIDLZXQAAZFNFI-UHFFFAOYSA-N 262322 N-ethyl-4-(3-sulfamoyl-2-(2H-tetrazol-5-yl)phenyl)piperidine-1-carboxamide::US9708336, 174 Metallo-beta-lactamase type 2 403 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262322 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262322&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118257338 376224150 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496120 NS(=O)(=O)c1cccc(C2CCCNC2)c1-c1nn[nH]n1 262323 3-(piperidin-3-yl)-2-(2H-tetrazol-5-yl)benzenesulfonamide::US9708336, 175 Metallo-beta-lactamase type 2 12370 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262323 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262323&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118256939 376224151 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496123 NS(=O)(=O)c1cccc(C2CCN(CC2)C(=O)C2(CC2)c2ccccc2)c1-c1nn[nH]n1 InChI=1S/C22H24N6O3S/c23-32(30,31)18-8-4-7-17(19(18)20-24-26-27-25-20)15-9-13-28(14-10-15)21(29)22(11-12-22)16-5-2-1-3-6-16/h1-8,15H,9-14H2,(H2,23,30,31)(H,24,25,26,27) KSDPOOMCMJUPCM-UHFFFAOYSA-N 262324 3-(1-(1-phenylcyclopropanecarbonyl)piperidin-4-yl)-2-(2H-tetrazol-5-yl)benzenesulfonamide::US9708336, 176 Metallo-beta-lactamase type 2 72.8 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262324 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262324&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823553 376224152 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496126 NS(=O)(=O)c1cccc(C2CCCN(C2)C(=O)C2CC2)c1-c1nn[nH]n1 262325 3-(1-(cyclopropanecarbonyl)piperidin-3-yl)-2-(2H-tetrazol-5-yl)benzenesulfonamide::US9708336, 177 Metallo-beta-lactamase type 2 668 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262325 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262325&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118257337 376224153 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496129 NS(=O)(=O)c1cccc(C2CCn3cncc3C2)c1-c1nn[nH]n1 262326 3-(5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-7-yl)-2-(2H-tetrazol-5-yl)benzenesulfonamide::US9708336, 178 Metallo-beta-lactamase type 2 1023 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262326 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262326&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118257134 376224154 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496132 Cc1ccc(Oc2cccc(c2-c2nn[nH]n2)S(N)(=O)=O)cc1 InChI=1S/C14H13N5O3S/c1-9-5-7-10(8-6-9)22-11-3-2-4-12(23(15,20)21)13(11)14-16-18-19-17-14/h2-8H,1H3,(H2,15,20,21)(H,16,17,18,19) KCRKILASLQZJIL-UHFFFAOYSA-N 262327 2-(2H-tetrazol-5-yl)-3-(p-tolyloxy)benzenesulfonamide::US9708336, 179 Metallo-beta-lactamase type 2 406 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262327 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262327&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118257007 376224155 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496135 NS(=O)(=O)c1cccc(-c2ccc(cc2)C2CCNC2)c1-c1nnn[nH]1 262328 4′-(pyrrolidin-3-yl)-2-(1H-tetrazol-5-yl)-[1,1′-biphenyl]-3-sulfonamide::US9708336, 180 Metallo-beta-lactamase type 2 113 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262328 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262328&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118257229 376224156 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496138 NS(=O)(=O)c1nccc(-c2ccc(CO)cc2)c1-c1nnn[nH]1 InChI=1S/C13H12N6O3S/c14-23(21,22)13-11(12-16-18-19-17-12)10(5-6-15-13)9-3-1-8(7-20)2-4-9/h1-6,20H,7H2,(H2,14,21,22)(H,16,17,18,19) ZLLPEJMJTQBWDI-UHFFFAOYSA-N 262329 4-(4-(Hydroxymethyl)phenyl)-3-(1H-tetrazol-5-yl)pyridine-2-sulfonamide::US9708336, 181 Metallo-beta-lactamase type 2 375 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262329 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262329&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823554 376224157 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496141 COC(=O)c1ccc(cc1)-c1ccnc(c1-c1nnn[nH]1)S(N)(=O)=O InChI=1S/C14H12N6O4S/c1-24-14(21)9-4-2-8(3-5-9)10-6-7-16-13(25(15,22)23)11(10)12-17-19-20-18-12/h2-7H,1H3,(H2,15,22,23)(H,17,18,19,20) FVNSWQDCPIYBIH-UHFFFAOYSA-N 262330 Methyl 4-(2-sulfamoyl-3-(1H-tetrazol-5-yl)pyridin-4-yl)benzoate::US9708336, 182 Metallo-beta-lactamase type 2 348 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262330 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262330&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118257202 376224158 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496144 NS(=O)(=O)c1nccc(-c2ccc(cc2)C(O)=O)c1-c1nnn[nH]1 InChI=1S/C13H10N6O4S/c14-24(22,23)12-10(11-16-18-19-17-11)9(5-6-15-12)7-1-3-8(4-2-7)13(20)21/h1-6H,(H,20,21)(H2,14,22,23)(H,16,17,18,19) UERQXOZQQLBNAL-UHFFFAOYSA-N 262331 4-(2-Sulfamoyl-3-(1H-tetrazol-5-yl)pyridin-4-yl)benzamide and 4-(2-Sulfamoyl-3-(1H-tetrazol-5-yl)pyridin-4-yl)benzoic acid::US9708336, 183 Metallo-beta-lactamase type 2 339 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262331 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262331&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823555 376224159 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496147 NC(=O)c1ccc(cc1)-c1ccnc(c1-c1nnn[nH]1)S(N)(=O)=O InChI=1S/C13H11N7O3S/c14-11(21)8-3-1-7(2-4-8)9-5-6-16-13(24(15,22)23)10(9)12-17-19-20-18-12/h1-6H,(H2,14,21)(H2,15,22,23)(H,17,18,19,20) IRHXAIWJOUJNSU-UHFFFAOYSA-N 262332 4-(2-Sulfamoyl-3-(1H-tetrazol-5-yl)pyridin-4-yl)benzamide::US9708336, 184 Metallo-beta-lactamase type 2 602 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262332 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262332&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118256777 376224160 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496150 NS(=O)(=O)c1nccc(-c2ccc(cc2)C(=O)NC2CC2)c1-c1nnn[nH]1 InChI=1S/C16H15N7O3S/c17-27(25,26)16-13(14-20-22-23-21-14)12(7-8-18-16)9-1-3-10(4-2-9)15(24)19-11-5-6-11/h1-4,7-8,11H,5-6H2,(H,19,24)(H2,17,25,26)(H,20,21,22,23) QWDAJOZABCMSHF-UHFFFAOYSA-N 262333 N-Cyclopropyl-4-(2-sulfamoyl-3-(1H-tetrazol-5-yl)pyridin-4-yl)benzamide::US9708336, 185 Metallo-beta-lactamase type 2 1478 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262333 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262333&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118257239 376224161 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496153 NS(=O)(=O)c1nccc(-c2ccc(cc2)C(=O)NC2CCOCC2)c1-c1nnn[nH]1 InChI=1S/C18H19N7O4S/c19-30(27,28)18-15(16-22-24-25-23-16)14(5-8-20-18)11-1-3-12(4-2-11)17(26)21-13-6-9-29-10-7-13/h1-5,8,13H,6-7,9-10H2,(H,21,26)(H2,19,27,28)(H,22,23,24,25) KIFHIBJIWUDZCO-UHFFFAOYSA-N 262334 4-(2-Sulfamoyl-3-(1H-tetrazol-5-yl)pyridin-4-yl)-N-(tetrahydro-2H-pyran-4-yl)benzamide::US9708336, 186 Metallo-beta-lactamase type 2 564 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262334 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262334&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118257170 376224162 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496156 NS(=O)(=O)c1nccc(-c2ccc(cc2)C2CCOCC2)c1-c1nnn[nH]1 InChI=1S/C17H18N6O3S/c18-27(24,25)17-15(16-20-22-23-21-16)14(5-8-19-17)13-3-1-11(2-4-13)12-6-9-26-10-7-12/h1-5,8,12H,6-7,9-10H2,(H2,18,24,25)(H,20,21,22,23) SBYZKUCRWICYFE-UHFFFAOYSA-N 262335 4-(4-(Tetrahydro-2H-pyran-4-yl)phenyl)-3-(1H-tetrazol-5-yl)pyridine-2-sulfonamide::US9708336, 187 Metallo-beta-lactamase type 2 28.9 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262335 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262335&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118257383 376224163 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496159 NS(=O)(=O)c1ccnc(-c2ccc(CO)cc2)c1-c1nnn[nH]1 InChI=1S/C13H12N6O3S/c14-23(21,22)10-5-6-15-12(11(10)13-16-18-19-17-13)9-3-1-8(7-20)2-4-9/h1-6,20H,7H2,(H2,14,21,22)(H,16,17,18,19) DYFBHJVSLCFRQD-UHFFFAOYSA-N 262336 2-(4-(Hydroxymethyl)phenyl)-3-(1H-tetrazol-5-yl)pyridine-4-sulfonamide::US9708336, 188 Metallo-beta-lactamase type 2 768 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262336 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262336&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118256917 376224164 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497137 NS(=O)(=O)c1c(ccc(-c2cccc3[n+]([O-])cccc23)c1-c1nn[nH]n1)C(F)(F)F InChI=1S/C17H11F3N6O3S/c18-17(19,20)12-7-6-11(9-3-1-5-13-10(9)4-2-8-26(13)27)14(15(12)30(21,28)29)16-22-24-25-23-16/h1-8H,(H2,21,28,29)(H,22,23,24,25) GDTWPVUJEAUCCR-UHFFFAOYSA-N 262661 5-(3-Sulfamoyl-2-(2H-tetrazol-5-yl)- 4-(trifluoromethyl)phenyl)quinoline 1- oxide::US9708336, 514 Metallo-beta-lactamase type 2 6.08 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262661 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262661&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823641 376224486 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497140 NS(=O)(=O)c1c(ccc(-c2cccc3cnccc23)c1-c1nn[nH]n1)C(F)(F)F InChI=1S/C17H11F3N6O2S/c18-17(19,20)13-5-4-12(11-3-1-2-9-8-22-7-6-10(9)11)14(15(13)29(21,27)28)16-23-25-26-24-16/h1-8H,(H2,21,27,28)(H,23,24,25,26) LXLFKNKVSFKPON-UHFFFAOYSA-N 262662 3-(Isoquinolin-5-yl)-2-(2H-tetrazol-5- yl)-6- (trifluoromethyl)benzenesulfonamide::US9708336, 515 Metallo-beta-lactamase type 2 3.68 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262662 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262662&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823642 376224487 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497143 NS(=O)(=O)c1c(ccc(-c2cccc3c[n+]([O-])ccc23)c1-c1nn[nH]n1)C(F)(F)F InChI=1S/C17H11F3N6O3S/c18-17(19,20)13-5-4-12(11-3-1-2-9-8-26(27)7-6-10(9)11)14(15(13)30(21,28)29)16-22-24-25-23-16/h1-8H,(H2,21,28,29)(H,22,23,24,25) CKLCGCBSJODNNN-UHFFFAOYSA-N 262663 5-(3-Sulfamoyl-2-(2H-tetrazol-5-yl)- 4- (trifluoromethyl)phenyl)isoquinoline 2-oxide::US9708336, 516 Metallo-beta-lactamase type 2 12.6 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262663 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262663&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823643 376224488 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497146 NS(=O)(=O)c1c(ccc(-c2cccc3CNCCc23)c1-c1nn[nH]n1)C(F)(F)F InChI=1S/C17H15F3N6O2S/c18-17(19,20)13-5-4-12(11-3-1-2-9-8-22-7-6-10(9)11)14(15(13)29(21,27)28)16-23-25-26-24-16/h1-5,22H,6-8H2,(H2,21,27,28)(H,23,24,25,26) HUJHSXQBDBAYCG-UHFFFAOYSA-N 262664 3-(1,2,3,4-Tetrahydroisoquinolin-5- yl)-2-(2H-tetrazol-5-yl)-6- (trifluoromethyl)benzenesulfonamide::US9708336, 517 Metallo-beta-lactamase type 2 37.2 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262664 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262664&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823644 376224489 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497149 NS(=O)(=O)c1c(ccc(-c2cccc3NCCCc23)c1-c1nnn[nH]1)C(F)(F)F InChI=1S/C17H15F3N6O2S/c18-17(19,20)12-7-6-11(9-3-1-5-13-10(9)4-2-8-22-13)14(15(12)29(21,27)28)16-23-25-26-24-16/h1,3,5-7,22H,2,4,8H2,(H2,21,27,28)(H,23,24,25,26) BMMOTEHACAQVCM-UHFFFAOYSA-N 262665 3-(1,2,3,4-Tetrahydroquinolin-5-yl)-2- (1H-tetrazol-5-yl)-6- (trifluoromethyl)benzenesulfonamide::US9708336, 518 Metallo-beta-lactamase type 2 1.62 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262665 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262665&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823645 376224490 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497152 NS(=O)(=O)c1cccc(C2CCCc3ncccc23)c1-c1nn[nH]n1 262666 3-(5,6,7,8-Tetrahydroquinolin-5-yl)-2- (2H-tetrazol-5-yl)benzenesulfonamide::US9708336, 519 Metallo-beta-lactamase type 2 766 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262666 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262666&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823646 376224491 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497155 C[N+]1(C)CCc2c(C1)cccc2-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)C(F)(F)F InChI=1S/C19H20F3N6O2S/c1-28(2)9-8-12-11(10-28)4-3-5-13(12)14-6-7-15(19(20,21)22)17(31(23,29)30)16(14)18-24-26-27-25-18/h3-7H,8-10H2,1-2H3,(H2,23,29,30)(H,24,25,26,27)/q+1 UFWPDVZYWQUGPN-UHFFFAOYSA-N 262667 2,2-Dimethyl-5-(3-sulfamoyl-2-(2H- tetrazol-5-yl)-4- (trifluoromethyl)phenyl)-1,2,3,4- tetrahydroisoquinolin-2-ium::US9708336, 520 Metallo-beta-lactamase type 2 52.6 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262667 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262667&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823647 376224492 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497158 NS(=O)(=O)c1cccc(-c2cccc3C(=O)COc23)c1-c1nn[nH]n1 InChI=1S/C15H11N5O4S/c16-25(22,23)12-6-2-3-8(13(12)15-17-19-20-18-15)9-4-1-5-10-11(21)7-24-14(9)10/h1-6H,7H2,(H2,16,22,23)(H,17,18,19,20) WXZXSYRPDUEHFF-UHFFFAOYSA-N 262668 3-(3-Oxo-2,3-dihydrobenzofuran-7- yl)-2-(2H-tetrazol-5- yl)benzenesulfonamide::US9708336, 521 Metallo-beta-lactamase type 2 559 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262668 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262668&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823648 376224493 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497161 NS(=O)(=O)c1cccc(-c2cccc3ccoc23)c1-c1nn[nH]n1 InChI=1S/C15H11N5O3S/c16-24(21,22)12-6-2-4-10(13(12)15-17-19-20-18-15)11-5-1-3-9-7-8-23-14(9)11/h1-8H,(H2,16,21,22)(H,17,18,19,20) MQBRTWWWJCFIOH-UHFFFAOYSA-N 262669 3-(Benzofuran-7-yl)-2-(2H-tetrazol-5- yl)benzenesulfonamide::US9708336, 522 Metallo-beta-lactamase type 2 263 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262669 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262669&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823649 376224494 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497164 Nc1cc(cnc1N)-c1cccc(c1-c1nn[nH]n1)S(N)(=O)=O InChI=1S/C12H12N8O2S/c13-8-4-6(5-16-11(8)14)7-2-1-3-9(23(15,21)22)10(7)12-17-19-20-18-12/h1-5H,13H2,(H2,14,16)(H2,15,21,22)(H,17,18,19,20) OYGPXHNNTGYYOT-UHFFFAOYSA-N 262670 3-(5,6-Diaminopyridin-3-yl)-2-(2H- tetrazol-5-yl)benzenesulfonamide::US9708336, 523 Metallo-beta-lactamase type 2 1210 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262670 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262670&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823650 376224495 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497167 NC(=N)NC1CCC(CCc2ccc(c(c2-c2nn[nH]n2)S(N)(=O)=O)C(F)(F)F)CC1 InChI=1S/C17H23F3N8O2S/c18-17(19,20)12-8-5-10(4-1-9-2-6-11(7-3-9)24-16(21)22)13(14(12)31(23,29)30)15-25-27-28-26-15/h5,8-9,11H,1-4,6-7H2,(H4,21,22,24)(H2,23,29,30)(H,25,26,27,28) MPMIINWHLGQHCL-UHFFFAOYSA-N 262671 3-(2-(4-Guanidinocyclohexyl)ethyl)- 2-(2H-tetrazol-5-yl)-6- (trifluoromethyl)benzenesulfonamide::US9708336, 524 Metallo-beta-lactamase type 2 5.13 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262671 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262671&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266511 376224496 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497170 NS(=O)(=O)c1c(ccc(-c2cccc3C(=O)NCc23)c1-c1nn[nH]n1)C(F)(F)F InChI=1S/C16H11F3N6O3S/c17-16(18,19)11-5-4-8(7-2-1-3-9-10(7)6-21-15(9)26)12(13(11)29(20,27)28)14-22-24-25-23-14/h1-5H,6H2,(H,21,26)(H2,20,27,28)(H,22,23,24,25) PPUGAOWVUMAOQW-UHFFFAOYSA-N 262672 3-(1-Oxoisoindolin-4-yl)-2-(2H- tetrazol-5-yl)-6- (trifluoromethyl)benzenesulfonamide::US9708336, 525 Metallo-beta-lactamase type 2 6.85 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262672 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262672&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823651 376224497 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497173 Nc1cccc2c(cc(nc12)C(O)=O)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)C(F)(F)F InChI=1S/C18H12F3N7O4S/c19-18(20,21)10-5-4-7(13(15(10)33(23,31)32)16-25-27-28-26-16)9-6-12(17(29)30)24-14-8(9)2-1-3-11(14)22/h1-6H,22H2,(H,29,30)(H2,23,31,32)(H,25,26,27,28) MCUXJGHZGUFPIZ-UHFFFAOYSA-N 262673 8-Amino-4-(3-sulfamoyl-2-(2H- tetrazol-5-yl)-4- (trifluoromethyl)phenyl)quinoline-2- carboxylic acid::US9708336, 526 Metallo-beta-lactamase type 2 4.58 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262673 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262673&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823652 376224498 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497176 NC(=O)c1ccc(cn1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)C(F)(F)F InChI=1S/C14H10F3N7O3S/c15-14(16,17)8-3-2-7(6-1-4-9(12(18)25)20-5-6)10(11(8)28(19,26)27)13-21-23-24-22-13/h1-5H,(H2,18,25)(H2,19,26,27)(H,21,22,23,24) RPJKUXXPODJECR-UHFFFAOYSA-N 262674 5-(3-Sulfamoyl-2-(2H-tetrazol-5-yl)- 4- (trifluoromethyl)phenyl)picolinamide::US9708336, 527 Metallo-beta-lactamase type 2 10.6 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262674 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262674&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823653 376224499 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497179 NC(=O)c1cc2cccc(-c3ccc(c(c3-c3nn[nH]n3)S(N)(=O)=O)C(F)(F)F)c2[nH]1 InChI=1S/C17H12F3N7O3S/c18-17(19,20)10-5-4-8(12(14(10)31(22,29)30)16-24-26-27-25-16)9-3-1-2-7-6-11(15(21)28)23-13(7)9/h1-6,23H,(H2,21,28)(H2,22,29,30)(H,24,25,26,27) KPQDHWUWPFPXJZ-UHFFFAOYSA-N 262675 7-(3-Sulfamoyl-2-(2H-tetrazol-5-yl)- 4-(trifluoromethyl)phenyl)-1H-indole- 2-carboxamide::US9708336, 528 Metallo-beta-lactamase type 2 0.425 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262675 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262675&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823654 376224500 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497182 NS(=O)(=O)c1c(ccc(-c2cccc3ncccc23)c1-c1nn[nH]n1)C1CC1 InChI=1S/C19H16N6O2S/c20-28(26,27)18-12(11-6-7-11)8-9-15(17(18)19-22-24-25-23-19)13-3-1-5-16-14(13)4-2-10-21-16/h1-5,8-11H,6-7H2,(H2,20,26,27)(H,22,23,24,25) XRPZZBJCYDAYRE-UHFFFAOYSA-N 262676 6-Cyclopropyl-3-(quinolin-5-yl)-2- (2H-tetrazol-5-yl)benzenesulfonamide::US9708336, 529 Metallo-beta-lactamase type 2 6.30 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262676 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262676&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823655 376224501 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497185 NS(=O)(=O)c1c(CCO)ccc(-c2cccc3ncccc23)c1-c1nn[nH]n1 InChI=1S/C18H16N6O3S/c19-28(26,27)17-11(8-10-25)6-7-14(16(17)18-21-23-24-22-18)12-3-1-5-15-13(12)4-2-9-20-15/h1-7,9,25H,8,10H2,(H2,19,26,27)(H,21,22,23,24) ZMPNMNFXOUUKMM-UHFFFAOYSA-N 262677 6-(2-Hydroxyethyl)-3-(quinolin-5-yl)- 2-(2H-tetrazol-5- yl)benzenesulfonamide::US9708336, 530 Metallo-beta-lactamase type 2 25.9 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262677 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262677&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823656 376224502 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497188 Nc1nc2c(cccc2s1)-c1ccc(CCO)c(c1-c1nn[nH]n1)S(N)(=O)=O InChI=1S/C16H15N7O3S2/c17-16-19-13-10(2-1-3-11(13)27-16)9-5-4-8(6-7-24)14(28(18,25)26)12(9)15-20-22-23-21-15/h1-5,24H,6-7H2,(H2,17,19)(H2,18,25,26)(H,20,21,22,23) ZOGZKYRUQSPGFC-UHFFFAOYSA-N 262678 3-(2-Aminobenzo[d]thiazol-4-yl)-6- (2-hydroxyethyl)-2-(2H-tetrazol-5- yl)benzenesulfonamide::US9708336, 531 Metallo-beta-lactamase type 2 32.1 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262678 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262678&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823657 376224503 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497191 Nc1nc2c(cccc2s1)-c1ccc(C(F)CO)c(c1-c1nn[nH]n1)S(N)(=O)=O 262679 3-(2-Aminobenzo[d]thiazol-4-yl)-6- (1-fluoro-2-hydroxyethyl)-2-(2H- tetrazol-5-yl)benzenesulfonamide::US9708336, 532 Metallo-beta-lactamase type 2 6.42 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262679 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262679&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823658 376224504 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497194 Nc1nc2c(cccc2s1)-c1ccc(CCCO)c(c1-c1nn[nH]n1)S(N)(=O)=O InChI=1S/C17H17N7O3S2/c18-17-20-14-11(4-1-5-12(14)28-17)10-7-6-9(3-2-8-25)15(29(19,26)27)13(10)16-21-23-24-22-16/h1,4-7,25H,2-3,8H2,(H2,18,20)(H2,19,26,27)(H,21,22,23,24) ZWUKVTYKBROXKP-UHFFFAOYSA-N 262680 3-(2-Aminobenzo[d]thiazol-4-yl)-6- (3-hydroxypropyl)-2-(2H-tetrazol-5- yl)benzenesulfonamide::US9708336, 533 Metallo-beta-lactamase type 2 16.6 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262680 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262680&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823659 376224505 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497197 Nc1nc2c(cccc2s1)-c1ccc(CCCCCO)c(c1-c1nn[nH]n1)S(N)(=O)=O InChI=1S/C19H21N7O3S2/c20-19-22-16-13(6-4-7-14(16)30-19)12-9-8-11(5-2-1-3-10-27)17(31(21,28)29)15(12)18-23-25-26-24-18/h4,6-9,27H,1-3,5,10H2,(H2,20,22)(H2,21,28,29)(H,23,24,25,26) YEXSMPGVXBWSMW-UHFFFAOYSA-N 262681 3-(2-Aminobenzo[d]thiazol-4-yl)-6- (5-hydroxypentyl)-2-(2H-tetrazol-5- yl)benzenesulfonamide::US9708336, 534 Metallo-beta-lactamase type 2 9.53 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262681 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262681&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823660 376224506 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497200 Nc1nc2c(cccc2s1)-c1ccc(CC2CCC2)c(c1-c1nn[nH]n1)S(N)(=O)=O InChI=1S/C19H19N7O2S2/c20-19-22-16-13(5-2-6-14(16)29-19)12-8-7-11(9-10-3-1-4-10)17(30(21,27)28)15(12)18-23-25-26-24-18/h2,5-8,10H,1,3-4,9H2,(H2,20,22)(H2,21,27,28)(H,23,24,25,26) NQUOZYSKCWWHKK-UHFFFAOYSA-N 262682 3-(2-Aminobenzo[d]thiazol-4-yl)-6- (cyclobutylmethyl)-2-(2H-tetrazol-5- yl)benzenesulfonamide::US9708336, 535 Metallo-beta-lactamase type 2 6.86 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262682 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262682&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823661 376224507 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497659 CC(CCCN)N[C@H]1CC[C@@H](CC1)c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)C(F)(F)F 262835 3-{4-[(4-amino-1- methylbutyl)amino]cyclo- hexyl)-2-(1H-tetrazol-5- yl)-6- (trifluoromethyl)benzene sulfonamide::US9708336, 688 Metallo-beta-lactamase type 2 158 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262835 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262835&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266666 376224659 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497662 NS(=O)(=O)c1c(ccc(C2CC[C@@H](CC2)NC2CCC3(CCNCC3)CC2)c1-c1nnn[nH]1)C(F)(F)F 262836 3-[4-(3- azaspiro[5.5]undec-9- ylamino)cyclohexyl]-2- (1H-tetrazol-5-yl)-6- (trifluoromethyl)benzene sulfonamide::US9708336, 689 Metallo-beta-lactamase type 2 52.1 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262836 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262836&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266664 376224660 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497665 NC1CCC(CC1)N[C@H]1CC[C@@H](CC1)c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)C(F)(F)F 262837 3-{4-[(4- aminocyclohexyl)amino] cyclohexyl}-2-(1H- tetrazol-5-yl)-6- (trifluoromethyl)benzene sulfonamide::US9708336, 690 Metallo-beta-lactamase type 2 75.9 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262837 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262837&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266395 376224661 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497668 NC1CCC(C1)N[C@H]1CC[C@@H](CC1)c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)C(F)(F)F 262838 3-{4-[(3- aminocyclopentyl)amino] cyclohexyl}-2-(1H- tetrazol-5-yl)-6- (trifluoromethyl)benzene sulfonamide::US9708336, 691::US9708336, 703 Metallo-beta-lactamase type 2 51.8 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262838 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262838&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266376 376224662 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497671 NS(=O)(=O)c1c(ccc([C@H]2CC[C@@H](CC2)NC2CC[C@H]3NCC[C@@H]23)c1-c1nnn[nH]1)C(F)(F)F 262839 3-{4-[(3aR,6aR)- octahydrocyclopenta[b] pyrrol-4- ylamino]cyclohexyl}-2- (1H-tetrazol-5-yl)-6- (trifluoromethyl)benzene sulfonamide::US9708336, 692 Metallo-beta-lactamase type 2 19.8 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262839 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262839&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266355 376224663 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497674 NCCC1CCC(CC1)N[C@H]1CC[C@@H](CC1)c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)C(F)(F)F 262840 3-(4-{[4-(2- aminoethyl)cyclohexyl]a- mino}cyclohexyl)-2-(1H- tetrazol-5-yl)-6- (trifluoromethyl)benzene sulfonamide::US9708336, 693::US9708336, 705 Metallo-beta-lactamase type 2 97.8 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262840 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262840&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266383 376224664 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497677 NC1CC(C1)N[C@H]1CC[C@@H](CC1)c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)C(F)(F)F 262841 3-{4-[(3- aminocyclobutyl)amino] cyclohexyl}-2-(1H- tetrazol-5-yl)-6- (trifluoromethyl)benzene sulfonamide::US9708336, 694::US9708336, 702 Metallo-beta-lactamase type 2 18.6 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262841 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262841&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266384 376224665 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497680 NS(=O)(=O)c1c(ccc([C@H]2CC[C@@H](CC2)NC2CCCNCC2)c1-c1nnn[nH]1)C(F)(F)F 262842 3-[4-(azepan-4- ylamino)cyclohexyl]-2- (1H-tetrazol-5-yl)-6- (trifluoromethyl)benzene sulfonamide::US9708336, 695 Metallo-beta-lactamase type 2 42.3 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262842 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262842&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266356 376224666 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497683 NS(=O)(=O)c1c(ccc([C@H]2CC[C@@H](CC2)NC2CCNC2)c1-c1nnn[nH]1)C(F)(F)F 262843 3-[4-(pyrrolidin-3- ylamino)cyclohexyl]-2- (1H-tetrazol-5-yl)-6- (trifluoromethyl)benzene sulfonamide::US9708336, 696 Metallo-beta-lactamase type 2 5.26 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262843 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262843&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266385 376224667 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497686 NS(=O)(=O)c1c(ccc([C@H]2CC[C@@H](CC2)NC2CCCNC2)c1-c1nnn[nH]1)C(F)(F)F 262844 3-[4-(piperidin-3- ylamino)cyclohexyl]-2- (1H-tetrazol-5-yl)-6- (trifluoromethyl)benzene sulfonamide::US9708336, 697 Metallo-beta-lactamase type 2 6.42 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262844 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262844&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266393 376224668 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497689 NS(=O)(=O)c1c(ccc([C@H]2CC[C@@H](CC2)NC2CCNCC2)c1-c1nnn[nH]1)C(F)(F)F 262845 3-[4-(piperidin-4- ylamino)cyclohexyl]-2- (1H-tetrazol-5-yl)-6- (trifluoromethyl)benzene sulfonamide::US9708336, 698 Metallo-beta-lactamase type 2 29.6 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262845 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262845&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266394 376224669 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497692 NCC1CCC(CC1)N[C@H]1CC[C@@H](CC1)c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)C(F)(F)F 262846 3-(4-{[4- (aminomethyl)cyclohexyl] amino}cyclohexyl)-2- (1H-tetrazol-5-yl)-6- (trifluoromethyl)benzene sulfonamide::US9708336, 699::US9708336, 704 Metallo-beta-lactamase type 2 58.8 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262846 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262846&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266396 376224670 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497695 NCCN[C@H]1CC[C@@H](CC1)c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)C(F)(F)F 262847 3-{4-[(2- aminoethyl)amino]cyclo- hexyl}-2-(1H-tetrazol-5- yl)-6- (trifluoromethyl)benzene sulfonamide::US9708336, 700 Metallo-beta-lactamase type 2 16.7 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262847 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262847&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118257280 376224671 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497698 NC1CCC(CC1)N[C@H]1CC[C@@H](CC1)c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)C(F)(F)F 262848 3-{4-[(4- aminocyclohexyl)amino] cyclohexyl}-2-(1H- tetrazol-5-yl)-6- (trifluoromethyl)benzene sulfonamide::US9708336, 701 Metallo-beta-lactamase type 2 62.9 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262848 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262848&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266395 376224672 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497701 NC1CC(C1)N[C@H]1CC[C@@H](CC1)c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)C(F)(F)F 262841 3-{4-[(3- aminocyclobutyl)amino] cyclohexyl}-2-(1H- tetrazol-5-yl)-6- (trifluoromethyl)benzene sulfonamide::US9708336, 694::US9708336, 702 Metallo-beta-lactamase type 2 25.2 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262841 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262841&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266384 376224665 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497704 NC1CCC(C1)N[C@H]1CC[C@@H](CC1)c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)C(F)(F)F 262838 3-{4-[(3- aminocyclopentyl)amino] cyclohexyl}-2-(1H- tetrazol-5-yl)-6- (trifluoromethyl)benzene sulfonamide::US9708336, 691::US9708336, 703 Metallo-beta-lactamase type 2 38.0 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262838 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262838&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266376 376224662 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497707 NCC1CCC(CC1)N[C@H]1CC[C@@H](CC1)c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)C(F)(F)F 262846 3-(4-{[4- (aminomethyl)cyclohexyl] amino}cyclohexyl)-2- (1H-tetrazol-5-yl)-6- (trifluoromethyl)benzene sulfonamide::US9708336, 699::US9708336, 704 Metallo-beta-lactamase type 2 51.6 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262846 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262846&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266396 376224670 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497710 NCCC1CCC(CC1)N[C@H]1CC[C@@H](CC1)c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)C(F)(F)F 262840 3-(4-{[4-(2- aminoethyl)cyclohexyl]a- mino}cyclohexyl)-2-(1H- tetrazol-5-yl)-6- (trifluoromethyl)benzene sulfonamide::US9708336, 693::US9708336, 705 Metallo-beta-lactamase type 2 61.1 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262840 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262840&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266383 376224664 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497713 NS(=O)(=O)c1c(ccc(-c2cnc(nc2)N2CCNCC2)c1-c1nnn[nH]1)C(F)(F)F InChI=1S/C16H16F3N9O2S/c17-16(18,19)11-2-1-10(12(13(11)31(20,29)30)14-24-26-27-25-14)9-7-22-15(23-8-9)28-5-3-21-4-6-28/h1-2,7-8,21H,3-6H2,(H2,20,29,30)(H,24,25,26,27) YMMBETSAJLOJKB-UHFFFAOYSA-N 262853 3-(2-piperazin-1-ylpyrimidin-5- yl)-2-(1H-tetrazol-5-yl)-6- (trifluoromethyl)benzenesulfon- amide::US9708336, 706 Metallo-beta-lactamase type 2 12.4 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262853 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262853&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823679 376224673 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497716 NCCc1ccc(cc1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)C(F)(F)F InChI=1S/C16H15F3N6O2S/c17-16(18,19)12-6-5-11(10-3-1-9(2-4-10)7-8-20)13(14(12)28(21,26)27)15-22-24-25-23-15/h1-6H,7-8,20H2,(H2,21,26,27)(H,22,23,24,25) YHIUWRWIXJRMRE-UHFFFAOYSA-N 262854 4'-(2-aminoethyl)-2-(1H- tetrazol-5-yl)-4- (trifluoromethyl)biphenyl-3- sulfonamide::US9708336, 707 Metallo-beta-lactamase type 2 6.67 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262854 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262854&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823680 376224674 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497719 NS(=O)(=O)c1c(ccc(-c2cnc3[nH]ccc3c2)c1-c1nnn[nH]1)C(F)(F)F InChI=1S/C15H10F3N7O2S/c16-15(17,18)10-2-1-9(8-5-7-3-4-20-13(7)21-6-8)11(12(10)28(19,26)27)14-22-24-25-23-14/h1-6H,(H,20,21)(H2,19,26,27)(H,22,23,24,25) AMTFOWMPAAPIMU-UHFFFAOYSA-N 262855 3-(1H-pyrrolo[2,3-b]pyridin-5- yl)-2-(1H-tetrazol-5-yl)-6- (trifluoromethyl)benzenesulfon- amide::US9708336, 708 Metallo-beta-lactamase type 2 1.60 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262855 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262855&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823681 376224675 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497722 NS(=O)(=O)c1c(ccc(-c2snc3ncccc23)c1-c1nnn[nH]1)C(F)(F)F InChI=1S/C14H8F3N7O2S2/c15-14(16,17)8-4-3-6(10-7-2-1-5-19-12(7)22-27-10)9(11(8)28(18,25)26)13-20-23-24-21-13/h1-5H,(H2,18,25,26)(H,20,21,23,24) DXRUADFAYNPEKY-UHFFFAOYSA-N 262856 3-isothiazolo[3,4-b]pyridin-3-yl- 2-(1H-tetrazol-5-yl)-6- (trifluoromethyl)benzenesulfon- amide::US9708336, 709 Metallo-beta-lactamase type 2 16.4 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262856 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262856&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823682 376224676 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496162 NS(=O)(=O)c1cncc(-c2ccc(CO)cc2)c1-c1nnn[nH]1 InChI=1S/C13H12N6O3S/c14-23(21,22)11-6-15-5-10(12(11)13-16-18-19-17-13)9-3-1-8(7-20)2-4-9/h1-6,20H,7H2,(H2,14,21,22)(H,16,17,18,19) IPEWPEWBTFTKFI-UHFFFAOYSA-N 262337 5-(4-(Hydroxymethyl)phenyl)-4-(1H-tetrazol-5-yl)pyridine-3-sulfonamide::US9708336, 189 Metallo-beta-lactamase type 2 704 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262337 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262337&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118257448 376224165 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496165 Cc1ccc(cc1)-c1ccnc(c1-c1nnn[nH]1)S(N)(=O)=O InChI=1S/C13H12N6O2S/c1-8-2-4-9(5-3-8)10-6-7-15-13(22(14,20)21)11(10)12-16-18-19-17-12/h2-7H,1H3,(H2,14,20,21)(H,16,17,18,19) WMPLABRDXMPSBL-UHFFFAOYSA-N 262338 3-(1H-Tetrazol-5-yl)-4-(p-tolyl)pyridine-2-sulfonamide::US9708336, 190 Metallo-beta-lactamase type 2 3150 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262338 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262338&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118256913 376224166 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496168 C[C@H]1NC(=O)OC1c1ccc(cc1)-c1ccnc(c1-c1nnn[nH]1)S(N)(=O)=O 262339 (+-)-4-(4-(cis-4-Methyl-2-oxooxazolidin-5-yl)phenyl)-3-(1H-tetrazol-5-yl)pyridine-2-sulfonamide::US9708336, 191 Metallo-beta-lactamase type 2 76.0 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262339 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262339&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 122694024 376224167 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496171 NS(=O)(=O)c1nccc(-c2ccc3C(=O)NCc3c2)c1-c1nnn[nH]1 InChI=1S/C14H11N7O3S/c15-25(23,24)14-11(12-18-20-21-19-12)9(3-4-16-14)7-1-2-10-8(5-7)6-17-13(10)22/h1-5H,6H2,(H,17,22)(H2,15,23,24)(H,18,19,20,21) ALNMGXOVWVPHTP-UHFFFAOYSA-N 262340 4-(1-oxoisoindolin-5-yl)-3-(1H- tetrazol-5-yl)pyridine-2- sulfonamide::US9708336, 192::US9708336, 196 Metallo-beta-lactamase type 2 439 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262340 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262340&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118265338 376224168 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496174 NS(=O)(=O)c1nccc(-c2cccnc2)c1-c1nnn[nH]1 InChI=1S/C11H9N7O2S/c12-21(19,20)11-9(10-15-17-18-16-10)8(3-5-14-11)7-2-1-4-13-6-7/h1-6H,(H2,12,19,20)(H,15,16,17,18) FKFAJJSSUUNPIH-UHFFFAOYSA-N 262341 3'-(1H-tetrazol-5-yl)-[3,4'- bipyridine]-2'-sulfonamide::US9708336, 193 Metallo-beta-lactamase type 2 2655 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262341 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262341&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118265336 376224169 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496177 NS(=O)(=O)c1nccc(-c2ccncc2)c1-c1nnn[nH]1 InChI=1S/C11H9N7O2S/c12-21(19,20)11-9(10-15-17-18-16-10)8(3-6-14-11)7-1-4-13-5-2-7/h1-6H,(H2,12,19,20)(H,15,16,17,18) XCJBGRMFQMQCJZ-UHFFFAOYSA-N 262342 3-(1H-tetrazol-5-yl)-[4,4'- bipyridine]-2-sulfonamide::US9708336, 194 Metallo-beta-lactamase type 2 2272 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262342 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262342&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118265339 376224170 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496180 NS(=O)(=O)c1nccc(-c2ccc(CO)nc2)c1-c1nnn[nH]1 InChI=1S/C12H11N7O3S/c13-23(21,22)12-10(11-16-18-19-17-11)9(3-4-14-12)7-1-2-8(6-20)15-5-7/h1-5,20H,6H2,(H2,13,21,22)(H,16,17,18,19) XUCNGCHWHUZOIZ-UHFFFAOYSA-N 262343 6-(hydroxymethyl)-3'-(1H- tetrazol-5-yl)-[3,4'-bipyridine]- 2'-sulfonamide::US9708336, 195 Metallo-beta-lactamase type 2 2629 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262343 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262343&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118265340 376224171 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496183 NS(=O)(=O)c1nccc(-c2ccc3C(=O)NCc3c2)c1-c1nnn[nH]1 InChI=1S/C14H11N7O3S/c15-25(23,24)14-11(12-18-20-21-19-12)9(3-4-16-14)7-1-2-10-8(5-7)6-17-13(10)22/h1-5H,6H2,(H,17,22)(H2,15,23,24)(H,18,19,20,21) ALNMGXOVWVPHTP-UHFFFAOYSA-N 262340 4-(1-oxoisoindolin-5-yl)-3-(1H- tetrazol-5-yl)pyridine-2- sulfonamide::US9708336, 192::US9708336, 196 Metallo-beta-lactamase type 2 1590 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262340 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262340&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118265338 376224168 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496186 NS(=O)(=O)c1nccc(-c2ccc(cc2)C2CCNCC2)c1-c1nnn[nH]1 InChI=1S/C17H19N7O2S/c18-27(25,26)17-15(16-21-23-24-22-16)14(7-10-20-17)13-3-1-11(2-4-13)12-5-8-19-9-6-12/h1-4,7,10,12,19H,5-6,8-9H2,(H2,18,25,26)(H,21,22,23,24) XWVYMXREVASDCK-UHFFFAOYSA-N 262345 4-(4-(piperidin-4-yl)phenyl)-3- (1H-tetrazol-5-yl)pyridine-2- sulfonamide::US9708336, 197 Metallo-beta-lactamase type 2 582 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262345 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262345&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823556 376224172 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496189 NS(=O)(=O)c1nccc(-c2ccc(cc2)C2CCNC2)c1-c1nnn[nH]1 262346 4-(4-(pyrrolidin-3-yl)phenyl)-3- (1H-tetrazol-5-yl)pyridine-2- sulfonamide::US9708336, 198 Metallo-beta-lactamase type 2 1166 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262346 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262346&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823557 376224173 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496192 NS(=O)(=O)c1nccc(-c2ccc3[nH]ncc3c2)c1-c1nn[nH]n1 InChI=1S/C13H10N8O2S/c14-24(22,23)13-11(12-18-20-21-19-12)9(3-4-15-13)7-1-2-10-8(5-7)6-16-17-10/h1-6H,(H,16,17)(H2,14,22,23)(H,18,19,20,21) YMPAKLNEAQDARN-UHFFFAOYSA-N 262347 4-(1H-indazol-5-yl)-3-(2H- tetrazol-5-yl)pyridine-2 sulfonamide::US9708336, 199 Metallo-beta-lactamase type 2 325 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262347 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262347&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266632 376224174 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496195 NS(=O)(=O)c1nccc(-c2ccc3ncccc3c2)c1-c1nn[nH]n1 InChI=1S/C15H11N7O2S/c16-25(23,24)15-13(14-19-21-22-20-14)11(5-7-18-15)9-3-4-12-10(8-9)2-1-6-17-12/h1-8H,(H2,16,23,24)(H,19,20,21,22) SELDXZJKHYMGHC-UHFFFAOYSA-N 262348 4-(quinolin-6-yl)-3-(2H- tetrazol-5-yl)pyridine-2- sulfonamide::US9708336, 200 Metallo-beta-lactamase type 2 963 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262348 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262348&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823558 376224175 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496198 NS(=O)(=O)c1nccc(-c2ccc3NC(=O)Cc3c2)c1-c1nn[nH]n1 InChI=1S/C14H11N7O3S/c15-25(23,24)14-12(13-18-20-21-19-13)9(3-4-16-14)7-1-2-10-8(5-7)6-11(22)17-10/h1-5H,6H2,(H,17,22)(H2,15,23,24)(H,18,19,20,21) FGMWATSYQZJGDH-UHFFFAOYSA-N 262349 4-(2-oxoindolin-5-yl)-3- (2H-tetrazol-5-yl)pyridine- 2-sulfonamide::US9708336, 201 Metallo-beta-lactamase type 2 1447 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262349 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262349&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823559 376224176 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496201 CS(=O)(=O)Nc1cccc(c1)-c1ccnc(c1-c1nn[nH]n1)S(N)(=O)=O InChI=1S/C13H13N7O4S2/c1-25(21,22)18-9-4-2-3-8(7-9)10-5-6-15-13(26(14,23)24)11(10)12-16-19-20-17-12/h2-7,18H,1H3,(H2,14,23,24)(H,16,17,19,20) OXUUGDDJVZZQJK-UHFFFAOYSA-N 262350 4-(3- (methylsulfonamido)phenyl)- 3-(2H-tetrazol-5- yl)pyridine-2-sulfonamide::US9708336, 202 Metallo-beta-lactamase type 2 23.8 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262350 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262350&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823560 376224177 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496204 NS(=O)(=O)c1nccc(-c2ccc3cn[nH]c3c2)c1-c1nn[nH]n1 InChI=1S/C13H10N8O2S/c14-24(22,23)13-11(12-18-20-21-19-12)9(3-4-15-13)7-1-2-8-6-16-17-10(8)5-7/h1-6H,(H,16,17)(H2,14,22,23)(H,18,19,20,21) QQZGABVSMLPCRJ-UHFFFAOYSA-N 262351 4-(1H-indazol-6-yl)-3-(2H- tetrazol-5-yl)pyridine-2- sulfonamide::US9708336, 203 Metallo-beta-lactamase type 2 1426 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262351 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262351&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266599 376224178 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496207 NC(=O)c1cccc(c1)-c1ccnc(c1-c1nn[nH]n1)S(N)(=O)=O InChI=1S/C13H11N7O3S/c14-11(21)8-3-1-2-7(6-8)9-4-5-16-13(24(15,22)23)10(9)12-17-19-20-18-12/h1-6H,(H2,14,21)(H2,15,22,23)(H,17,18,19,20) FYXORXYXCKRWLL-UHFFFAOYSA-N 262352 3-(2-sulfamoyl-3-(2H- tetrazol-5-yl)pyridin-4- yl)benzamide::US9708336, 204 Metallo-beta-lactamase type 2 2855 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262352 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262352&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823561 376224179 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496210 NS(=O)(=O)c1nccc(-c2ccc3NC(=O)COc3c2)c1-c1nn[nH]n1 InChI=1S/C14H11N7O4S/c15-26(23,24)14-12(13-18-20-21-19-13)8(3-4-16-14)7-1-2-9-10(5-7)25-6-11(22)17-9/h1-5H,6H2,(H,17,22)(H2,15,23,24)(H,18,19,20,21) MSRPPMKTNLLPSB-UHFFFAOYSA-N 262353 4-(3-oxo-3,4-dihydro-2H- benzo[b][1,4]oxazin-7-yl)- 3-(2H-tetrazol-5- yl)pyridine-2-sulfonamide::US9708336, 205 Metallo-beta-lactamase type 2 113 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262353 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262353&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823562 376224180 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496213 CS(=O)(=O)Nc1ccc(cc1)-c1ccnc(c1-c1nn[nH]n1)S(N)(=O)=O InChI=1S/C13H13N7O4S2/c1-25(21,22)18-9-4-2-8(3-5-9)10-6-7-15-13(26(14,23)24)11(10)12-16-19-20-17-12/h2-7,18H,1H3,(H2,14,23,24)(H,16,17,19,20) ZDHKLIKYBALHKG-UHFFFAOYSA-N 262354 4-(4- (methylsulfonamido)phenyl)- 3-(2H-tetrazol-5- yl)pyridine-2-sulfonamide::US9708336, 206 Metallo-beta-lactamase type 2 91.5 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262354 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262354&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823563 376224181 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496216 NS(=O)(=O)c1nccc(-c2ccccc2)c1-c1nn[nH]n1 InChI=1S/C12H10N6O2S/c13-21(19,20)12-10(11-15-17-18-16-11)9(6-7-14-12)8-4-2-1-3-5-8/h1-7H,(H2,13,19,20)(H,15,16,17,18) YVJCYRYVQKBMEG-UHFFFAOYSA-N 262355 4-phenyl-3-(2H-tetrazol-5- yl)pyridine-2-sulfonamide::US9708336, 207 Metallo-beta-lactamase type 2 373 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262355 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262355&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823564 376224182 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496219 NS(=O)(=O)c1nccc(-c2ccc(nc2)N2CCOCC2)c1-c1nn[nH]n1 InChI=1S/C15H16N8O3S/c16-27(24,25)15-13(14-19-21-22-20-14)11(3-4-17-15)10-1-2-12(18-9-10)23-5-7-26-8-6-23/h1-4,9H,5-8H2,(H2,16,24,25)(H,19,20,21,22) BRHOXMUVONWUOV-UHFFFAOYSA-N 262356 6-morpholino-3'-(2H- tetrazol-5-yl)-[3,4'- bipyridine]-2'-sulfonamide::US9708336, 208 Metallo-beta-lactamase type 2 589 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262356 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262356&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823565 376224183 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496222 NS(=O)(=O)c1nccc(-c2ccc3[nH]nc(c3c2)C(F)(F)F)c1-c1nn[nH]n1 InChI=1S/C14H9F3N8O2S/c15-14(16,17)11-8-5-6(1-2-9(8)20-21-11)7-3-4-19-13(28(18,26)27)10(7)12-22-24-25-23-12/h1-5H,(H,20,21)(H2,18,26,27)(H,22,23,24,25) PRWMWKGLGZMKOA-UHFFFAOYSA-N 262357 3-(2H-tetrazol-5-yl)-4-(3- (trifluoromethyl)-1H- indazol-5-yl)pyridine-2- sulfonamide::US9708336, 209 Metallo-beta-lactamase type 2 516 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262357 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262357&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118265920 376224184 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496225 Cc1ccccc1-c1ccnc(c1-c1nn[nH]n1)S(N)(=O)=O InChI=1S/C13H12N6O2S/c1-8-4-2-3-5-9(8)10-6-7-15-13(22(14,20)21)11(10)12-16-18-19-17-12/h2-7H,1H3,(H2,14,20,21)(H,16,17,18,19) ASTSVKHRTFVDSM-UHFFFAOYSA-N 262358 3-(2H-tetrazol-5-yl)-4-(o- tolyl)pyridine-2- sulfonamide::US9708336, 210 Metallo-beta-lactamase type 2 421 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262358 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262358&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823566 376224185 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497203 Nc1ncc(s1)-c1ccc(-c2cccc3sc(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C17H13N9O2S3/c18-16-21-6-11(30-16)9-5-4-7(8-2-1-3-10-13(8)22-17(19)29-10)12(14(9)31(20,27)28)15-23-25-26-24-15/h1-6H,(H2,18,21)(H2,19,22)(H2,20,27,28)(H,23,24,25,26) XZXUWWIGGLOHKS-UHFFFAOYSA-N 262683 3-(2-Aminobenzo[d]thiazol-4-yl)-6- (2-aminothiazol-5-yl)-2-(2H-tetrazol- 5-yl)benzenesulfonamide::US9708336, 536 Metallo-beta-lactamase type 2 39.4 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262683 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262683&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823662 376224508 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497206 CC(C)(C)Cc1ccc(-c2cccc3sc(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C19H21N7O2S2/c1-19(2,3)9-10-7-8-11(12-5-4-6-13-15(12)22-18(20)29-13)14(16(10)30(21,27)28)17-23-25-26-24-17/h4-8H,9H2,1-3H3,(H2,20,22)(H2,21,27,28)(H,23,24,25,26) IZJDTDONVOTEEA-UHFFFAOYSA-N 262684 3-(2-Aminobenzo[d]thiazol-4-yl)-6- neopentyl-2-(2H-tetrazol-5- yl)benzenesulfonamide::US9708336, 537 Metallo-beta-lactamase type 2 19.2 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262684 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262684&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823663 376224509 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497209 Nc1nc2c(cccc2s1)-c1ccc(CCC(O)=O)c(c1-c1nn[nH]n1)S(N)(=O)=O InChI=1S/C17H15N7O4S2/c18-17-20-14-10(2-1-3-11(14)29-17)9-6-4-8(5-7-12(25)26)15(30(19,27)28)13(9)16-21-23-24-22-16/h1-4,6H,5,7H2,(H2,18,20)(H,25,26)(H2,19,27,28)(H,21,22,23,24) KXADOOVDUCNPEW-UHFFFAOYSA-N 262685 3-(4-(2-Aminobenzo[d]thiazol-4-yl)- 2-sulfamoyl-3-(2H-tetrazol-5- yl)phenyl)propanoic acid::US9708336, 538 Metallo-beta-lactamase type 2 53.8 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262685 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262685&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823664 376224510 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497212 NC(=O)CCc1ccc(-c2cccc3sc(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C17H16N8O3S2/c18-12(26)7-5-8-4-6-9(10-2-1-3-11-14(10)21-17(19)29-11)13(15(8)30(20,27)28)16-22-24-25-23-16/h1-4,6H,5,7H2,(H2,18,26)(H2,19,21)(H2,20,27,28)(H,22,23,24,25) LSTRFDIFJJMPDA-UHFFFAOYSA-N 262686 3-(4-(2-Aminobenzo[d]thiazol-4-yl)- 2-sulfamoyl-3-(2H-tetrazol-5- yl)phenyl)propanamide::US9708336, 539 Metallo-beta-lactamase type 2 7.62 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262686 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262686&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823665 376224511 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497215 Nc1nc2c(cccc2s1)-c1ccc(CCC2CCNCC2)c(c1-c1nn[nH]n1)S(N)(=O)=O InChI=1S/C21H24N8O2S2/c22-21-25-18-15(2-1-3-16(18)32-21)14-7-6-13(5-4-12-8-10-24-11-9-12)19(33(23,30)31)17(14)20-26-28-29-27-20/h1-3,6-7,12,24H,4-5,8-11H2,(H2,22,25)(H2,23,30,31)(H,26,27,28,29) AJTQAFXTVVRQHU-UHFFFAOYSA-N 262687 3-(2-Aminobenzo[d]thiazol-4-yl)-6- (2-(piperidin-4-yl)ethyl)-2-(2H- tetrazol-5-yl)benzenesulfonamide::US9708336, 540 Metallo-beta-lactamase type 2 20.8 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262687 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262687&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823666 376224512 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497218 NC1CCC(CCc2ccc(-c3cccc4sc(N)nc34)c(-c3nn[nH]n3)c2S(N)(=O)=O)CC1 InChI=1S/C22H26N8O2S2/c23-14-9-5-12(6-10-14)4-7-13-8-11-15(16-2-1-3-17-19(16)26-22(24)33-17)18(20(13)34(25,31)32)21-27-29-30-28-21/h1-3,8,11-12,14H,4-7,9-10,23H2,(H2,24,26)(H2,25,31,32)(H,27,28,29,30) IFMLKRYHIGEBQR-UHFFFAOYSA-N 262688 3-(2-Aminobenzo[d]thiazol-4-yl)-6- (2-(4-aminocyclohexyl)ethyl)-2-(2H- tetrazol-5-yl)benzenesulfonamide::US9708336, 541 Metallo-beta-lactamase type 2 7.21 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262688 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262688&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823667 376224513 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497221 NS(=O)(=O)c1c(CCCCCO)ccc(CCCCCO)c1-c1nn[nH]n1 InChI=1S/C17H27N5O4S/c18-27(25,26)16-14(8-4-2-6-12-24)10-9-13(7-3-1-5-11-23)15(16)17-19-21-22-20-17/h9-10,23-24H,1-8,11-12H2,(H2,18,25,26)(H,19,20,21,22) ZBZXCLMBKAMIPR-UHFFFAOYSA-N 262689 3,6-Bis(5-hydroxypentyl)-2-(2H- tetrazol-5-yl)benzenesulfonamide::US9708336, 542 Metallo-beta-lactamase type 2 7.90 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262689 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262689&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118265986 376224514 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497224 NS(=O)(=O)c1c(CCCCCCO)ccc(CCCCCCO)c1-c1nn[nH]n1 InChI=1S/C19H31N5O4S/c20-29(27,28)18-16(10-6-2-4-8-14-26)12-11-15(9-5-1-3-7-13-25)17(18)19-21-23-24-22-19/h11-12,25-26H,1-10,13-14H2,(H2,20,27,28)(H,21,22,23,24) DEWDKNCNDOFTRD-UHFFFAOYSA-N 262690 3,6-Bis(6-hydroxyhexyl)-2-(2H- tetrazol-5-yl)benzenesulfonamide::US9708336, 543 Metallo-beta-lactamase type 2 1.16 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262690 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262690&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118265991 376224515 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497227 Nc1nc2c(cccc2s1)-c1ccc(cc1-c1nn[nH]n1)C(C1CCNCC1)S(N)(=O)=O 262691 3-(2-aminobenzo[d]thiazol-4-yl)-6-(piperidin-4-ylmethyl)-2-(2H-tetrazol-5-yl)benzenesulfonamide::US9708336, 544 Metallo-beta-lactamase type 2 19.2 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262691 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262691&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 122697354 376224516 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497230 Nc1nc2c(cccc2s1)-c1ccc(CC2CNC2)c(c1-c1nn[nH]n1)S(N)(=O)=O InChI=1S/C18H18N8O2S2/c19-18-22-15-12(2-1-3-13(15)29-18)11-5-4-10(6-9-7-21-8-9)16(30(20,27)28)14(11)17-23-25-26-24-17/h1-5,9,21H,6-8H2,(H2,19,22)(H2,20,27,28)(H,23,24,25,26) OHFLMMQISMVZEV-UHFFFAOYSA-N 262692 3-(2-aminobenzo[d]thiazol-4-yl)-6-(azetidin-3-ylmethyl)-2-(2H-tetrazol-5-yl)benzenesulfonamide::US9708336, 545 Metallo-beta-lactamase type 2 21.8 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262692 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262692&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266455 376224517 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497233 NS(=O)(=O)c1c(CC2CNC2)ccc(-c2cnc3ccccn23)c1-c1nn[nH]n1 InChI=1S/C18H18N8O2S/c19-29(27,28)17-12(7-11-8-20-9-11)4-5-13(16(17)18-22-24-25-23-18)14-10-21-15-3-1-2-6-26(14)15/h1-6,10-11,20H,7-9H2,(H2,19,27,28)(H,22,23,24,25) UFRNEDVENFSEJL-UHFFFAOYSA-N 262693 6-(azetidin-3-ylmethyl)-3-(imidazo[1,2-a]pyridin-3-yl)-2-(2H-tetrazol-5-yl)benzenesulfonamide::US9708336, 546 Metallo-beta-lactamase type 2 178 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262693 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262693&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118265981 376224518 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497236 N[C@@]1(CCNC1)c1ccc(cc1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)C(F)(F)F 262694 3-[4-[(3S)-3-aminopyrrolidin- 3-yl]phenyl]-2-(2H-tetrazol-5- yl)-6- (trifluoromethyl)benzenesulfon- amide::US9708336, 547 Metallo-beta-lactamase type 2 9.14 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262694 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262694&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266450 376224519 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497239 N[C@]1(CCNC1)c1ccc(cc1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)C(F)(F)F 262695 3-[4-[(3R)-3-aminopyrrolidin- 3-yl]phenyl]-2-(2H-tetrazol-5- yl)-6- (trifluoromethyl)benzenesulfon- amide::US9708336, 548 Metallo-beta-lactamase type 2 10.5 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262695 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262695&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266452 376224520 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497242 Nc1nc2ccc(cc2s1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)C(F)(F)F InChI=1S/C15H10F3N7O2S2/c16-15(17,18)8-3-2-7(6-1-4-9-10(5-6)28-14(19)21-9)11(12(8)29(20,26)27)13-22-24-25-23-13/h1-5H,(H2,19,21)(H2,20,26,27)(H,22,23,24,25) QTHCDURYBZDBOQ-UHFFFAOYSA-N 262696 3-(2-amino-1,3-benzothiazol- 6-yl)-2-(1H-tetrazol-5-yl)-6- (trifluoromethyl)benzenesulfon- amide::US9708336, 549 Metallo-beta-lactamase type 2 0.472 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262696 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262696&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266297 376224521 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497245 Nc1nc2cc(ccc2s1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)C(F)(F)F InChI=1S/C15H10F3N7O2S2/c16-15(17,18)8-3-2-7(6-1-4-10-9(5-6)21-14(19)28-10)11(12(8)29(20,26)27)13-22-24-25-23-13/h1-5H,(H2,19,21)(H2,20,26,27)(H,22,23,24,25) SSXXSOQOOASFOQ-UHFFFAOYSA-N 262697 3-(2-amino-1,3-benzothiazol- 5-yl)-2-(1H-tetrazol-5-yl)-6- (trifluoromethyl)benzenesulfon- amide::US9708336, 550 Metallo-beta-lactamase type 2 2.52 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262697 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262697&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266301 376224522 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497248 Nc1nc2cccc(-c3ccc(c(c3-c3nnn[nH]3)S(N)(=O)=O)C(F)(F)F)c2[nH]1 InChI=1S/C15H11F3N8O2S/c16-15(17,18)8-5-4-6(7-2-1-3-9-11(7)22-14(19)21-9)10(12(8)29(20,27)28)13-23-25-26-24-13/h1-5H,(H3,19,21,22)(H2,20,27,28)(H,23,24,25,26) KFPSHECGQIXYEL-UHFFFAOYSA-N 262698 3-(2-amino-3H-benzimidazol- 4-yl)-2-(1H-tetrazol-5-yl)-6- (trifluoromethyl)benzenesulfon- amide::US9708336, 551 Metallo-beta-lactamase type 2 3.80 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262698 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262698&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266485 376224523 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497251 Nc1nc2ccc(cc2[nH]1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)C(F)(F)F InChI=1S/C15H11F3N8O2S/c16-15(17,18)8-3-2-7(6-1-4-9-10(5-6)22-14(19)21-9)11(12(8)29(20,27)28)13-23-25-26-24-13/h1-5H,(H3,19,21,22)(H2,20,27,28)(H,23,24,25,26) LTIUZLULYVMQOL-UHFFFAOYSA-N 262699 3-(2-amino-3H-benzimidazol- 5-yl)-2-(1H-tetrazol-5-yl)-6- (trifluoromethyl)benzenesulfon- amide::US9708336, 552 Metallo-beta-lactamase type 2 7.20 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262699 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262699&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266451 376224524 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497254 Nc1nc2cccc(-c3ccc(c(c3-c3nnn[nH]3)S(N)(=O)=O)C(F)(F)F)c2s1 InChI=1S/C15H10F3N7O2S2/c16-15(17,18)8-5-4-6(7-2-1-3-9-11(7)28-14(19)21-9)10(12(8)29(20,26)27)13-22-24-25-23-13/h1-5H,(H2,19,21)(H2,20,26,27)(H,22,23,24,25) UPRWRNZMVXAVLM-UHFFFAOYSA-N 262700 3-(2-amino-1,3-benzothiazol- 7-yl)-2-(1H-tetrazol-5-yl)-6- (trifluoromethyl)benzenesulfon- amide::US9708336, 553 Metallo-beta-lactamase type 2 0.959 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262700 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262700&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823668 376224525 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497257 Nc1ccc2cccc(-c3ccc(c(c3-c3nn[nH]n3)S(N)(=O)=O)C(F)(F)F)c2n1 InChI=1S/C17H12F3N7O2S/c18-17(19,20)11-6-5-9(10-3-1-2-8-4-7-12(21)23-14(8)10)13(15(11)30(22,28)29)16-24-26-27-25-16/h1-7H,(H2,21,23)(H2,22,28,29)(H,24,25,26,27) FEIKQQMUNRZBMF-UHFFFAOYSA-N 262701 3-(2-amino-8-quinolyl)-2-(2H- tetrazol-5-yl)-6- (trifluoromethyl)benzenesulfon- amide::US9708336, 554 Metallo-beta-lactamase type 2 0.818 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262701 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262701&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266335 376224526 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497260 Cc1nc(N)ccc1-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)C(F)(F)F InChI=1S/C14H12F3N7O2S/c1-6-7(3-5-10(18)20-6)8-2-4-9(14(15,16)17)12(27(19,25)26)11(8)13-21-23-24-22-13/h2-5H,1H3,(H2,18,20)(H2,19,25,26)(H,21,22,23,24) TWKZIYPQRZTLNJ-UHFFFAOYSA-N 262702 3-(6-amino-2-methyl-3- pyridyl)-2-(2H-tetrazol-5-yl)- 6- (trifluoromethyl)benzenesulfon- amide::US9708336, 555 Metallo-beta-lactamase type 2 8.92 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262702 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262702&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266328 376224527 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497263 Nc1ncc2c(cccc2n1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)C(F)(F)F InChI=1S/C16H11F3N8O2S/c17-16(18,19)10-5-4-8(7-2-1-3-11-9(7)6-22-15(20)23-11)12(13(10)30(21,28)29)14-24-26-27-25-14/h1-6H,(H2,20,22,23)(H2,21,28,29)(H,24,25,26,27) MSVOTOYDDFNLRA-UHFFFAOYSA-N 262703 3-(2-aminoquinazolin-5-yl)-2- (2H-tetrazol-5-yl)-6- (trifluoromethyl)benzenesulfon- amide::US9708336, 556 Metallo-beta-lactamase type 2 2.97 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262703 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262703&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266350 376224528 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497266 Cc1cc(N)ncc1-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)C(F)(F)F InChI=1S/C14H12F3N7O2S/c1-6-4-10(18)20-5-8(6)7-2-3-9(14(15,16)17)12(27(19,25)26)11(7)13-21-23-24-22-13/h2-5H,1H3,(H2,18,20)(H2,19,25,26)(H,21,22,23,24) VDZJOHWBUZJWHU-UHFFFAOYSA-N 262704 3-(6-amino-4-methyl-3- pyridyl)-2-(2H-tetrazol-5-yl)- 6-(trifluoromethyl) benzenesulfonamide::US9708336, 557 Metallo-beta-lactamase type 2 8.08 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262704 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262704&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266353 376224529 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497725 NS(=O)(=O)c1c(ccc(-c2cnn3ccccc23)c1-c1nnn[nH]1)C(F)(F)F InChI=1S/C15H10F3N7O2S/c16-15(17,18)10-5-4-8(9-7-20-25-6-2-1-3-11(9)25)12(13(10)28(19,26)27)14-21-23-24-22-14/h1-7H,(H2,19,26,27)(H,21,22,23,24) IVOSQGJLCBREPJ-UHFFFAOYSA-N 262857 3-pyrazolo[1,5-a]pyridin-3-yl-2- (1H-tetrazol-5-yl)-6- (trifluoromethyl)benzenesulfon- amide::US9708336, 710 Metallo-beta-lactamase type 2 2.08 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262857 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262857&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823683 376224677 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497728 NS(=O)(=O)c1c(ccc(-c2cnc3ccoc3c2)c1-c1nnn[nH]1)C(F)(F)F InChI=1S/C15H9F3N6O3S/c16-15(17,18)9-2-1-8(7-5-11-10(20-6-7)3-4-27-11)12(13(9)28(19,25)26)14-21-23-24-22-14/h1-6H,(H2,19,25,26)(H,21,22,23,24) ZQDMCRGTKJMMOF-UHFFFAOYSA-N 262858 3-furo[3,2-b]pyridin-6-yl-2-(1H- tetrazol-5-yl)-6- (trifluoromethyl)benzenesulfon- amide::US9708336, 711 Metallo-beta-lactamase type 2 3.54 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262858 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262858&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823684 376224678 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497731 NS(=O)(=O)c1c(ccc(-c2cnc3ncccn23)c1-c1nnn[nH]1)C(F)(F)F InChI=1S/C14H9F3N8O2S/c15-14(16,17)8-3-2-7(9-6-20-13-19-4-1-5-25(9)13)10(11(8)28(18,26)27)12-21-23-24-22-12/h1-6H,(H2,18,26,27)(H,21,22,23,24) YJQQRBYBRZCTRZ-UHFFFAOYSA-N 262859 3-imidazo[1,2-a]pyrimidin-3-yl- 2-(1H-tetrazol-5-yl)-6- (trifluoromethyl)benzenesulfon- amide::US9708336, 712 Metallo-beta-lactamase type 2 126 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262859 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262859&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823685 376224679 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497734 NS(=O)(=O)c1c(ccc(-c2ccc(cc2)C2CNCCO2)c1-c1nnn[nH]1)C(F)(F)F 262860 4'-morpholin-2-yl-2-(1H- tetrazol-5-yl)-4- (trifluoromethyl)biphenyl-3- sulfonamide::US9708336, 713 Metallo-beta-lactamase type 2 3.54 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262860 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262860&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823686 376224680 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497737 Nc1cc(cc(N)n1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)C(F)(F)F InChI=1S/C13H11F3N8O2S/c14-13(15,16)7-2-1-6(5-3-8(17)20-9(18)4-5)10(11(7)27(19,25)26)12-21-23-24-22-12/h1-4H,(H4,17,18,20)(H2,19,25,26)(H,21,22,23,24) MAAIRMXAGVYGEP-UHFFFAOYSA-N 262861 3-(2,6-diaminopyridin-4-yl)-2- (1H-tetrazol-5-yl)-6- (trifluoromethyl)benzenesulfon- amide::US9708336, 714 Metallo-beta-lactamase type 2 31.7 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262861 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262861&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823687 376224681 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497740 NS(=O)(=O)c1c(ccc(-c2ccc3CNCc3c2)c1-c1nnn[nH]1)C(F)(F)F InChI=1S/C16H13F3N6O2S/c17-16(18,19)12-4-3-11(8-1-2-9-6-21-7-10(9)5-8)13(14(12)28(20,26)27)15-22-24-25-23-15/h1-5,21H,6-7H2,(H2,20,26,27)(H,22,23,24,25) UZENRFZKKXIQIV-UHFFFAOYSA-N 262862 3-(2,3-dihydro-1H-isoindol-5- yl)-2-(1H-tetrazol-5-yl)-6- (trifluoromethyl)benzenesulfon- amide::US9708336, 715 Metallo-beta-lactamase type 2 27.4 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262862 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262862&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823688 376224682 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497743 NS(=O)(=O)c1c(ccc(-c2ccc(cc2)C2CCCN2)c1-c1nnn[nH]1)C(F)(F)F 262863 4'-pyrrolidin-2-yl-2-(1H- tetrazol-5-yl)-4- (trifluoromethyl)biphenyl-3- sulfonamide::US9708336, 716 Metallo-beta-lactamase type 2 5.43 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262863 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262863&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823689 376224683 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497746 NS(=O)(=O)c1c(ccc(-c2ccc(cc2)N2CCNCC2)c1-c1nnn[nH]1)C(F)(F)F InChI=1S/C18H18F3N7O2S/c19-18(20,21)14-6-5-13(15(16(14)31(22,29)30)17-24-26-27-25-17)11-1-3-12(4-2-11)28-9-7-23-8-10-28/h1-6,23H,7-10H2,(H2,22,29,30)(H,24,25,26,27) NYOPLWUHMWBCFF-UHFFFAOYSA-N 262864 4'-piperazin-1-yl-2-(1H-tetrazol- 5-yl)-4- (trifluoromethyl)biphenyl-3- sulfonamide::US9708336, 717 Metallo-beta-lactamase type 2 2.62 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262864 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262864&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823690 376224684 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497749 NS(=O)(=O)c1c(ccc(-c2ccc(CN3CCNCC3)cc2)c1-c1nnn[nH]1)C(F)(F)F InChI=1S/C19H20F3N7O2S/c20-19(21,22)15-6-5-14(16(17(15)32(23,30)31)18-25-27-28-26-18)13-3-1-12(2-4-13)11-29-9-7-24-8-10-29/h1-6,24H,7-11H2,(H2,23,30,31)(H,25,26,27,28) PISBYTXXJQEHPY-UHFFFAOYSA-N 262865 4'-(piperazin-1-ylmethyl)-2-(1H- tetrazol-5-yl)-4- (trifluoromethyl)biphenyl-3- sulfonamide::US9708336, 718 Metallo-beta-lactamase type 2 2.40 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262865 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262865&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823691 376224685 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497752 NS(=O)(=O)c1c(ccc(-c2ccc(OC3CNC3)cc2)c1-c1nnn[nH]1)C(F)(F)F InChI=1S/C17H15F3N6O3S/c18-17(19,20)13-6-5-12(9-1-3-10(4-2-9)29-11-7-22-8-11)14(15(13)30(21,27)28)16-23-25-26-24-16/h1-6,11,22H,7-8H2,(H2,21,27,28)(H,23,24,25,26) RBYBTBUOPKUUIR-UHFFFAOYSA-N 262866 4'-(azetidin-3-yloxy)-2-(1H- tetrazol-5-yl)-4- (trifluoromethyl)biphenyl-3- sulfonamide::US9708336, 719 Metallo-beta-lactamase type 2 3.68 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262866 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262866&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823692 376224686 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497755 NS(=O)(=O)c1c(ccc(-c2ccc3CCNCc3c2)c1-c1nnn[nH]1)C(F)(F)F InChI=1S/C17H15F3N6O2S/c18-17(19,20)13-4-3-12(10-2-1-9-5-6-22-8-11(9)7-10)14(15(13)29(21,27)28)16-23-25-26-24-16/h1-4,7,22H,5-6,8H2,(H2,21,27,28)(H,23,24,25,26) KHCNIYBOJVWPOS-UHFFFAOYSA-N 262867 3-(1,2,3,4- tetrahydroisoquinolin-7-yl)-2- (1H-tetrazol-5-yl)-6- (trifluoromethyl)benzenesulfon- amide::US9708336, 720 Metallo-beta-lactamase type 2 16.1 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262867 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262867&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823693 376224687 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497758 NS(=O)(=O)c1c(ccc(-c2ccc3CNCCc3c2)c1-c1nnn[nH]1)C(F)(F)F InChI=1S/C17H15F3N6O2S/c18-17(19,20)13-4-3-12(10-1-2-11-8-22-6-5-9(11)7-10)14(15(13)29(21,27)28)16-23-25-26-24-16/h1-4,7,22H,5-6,8H2,(H2,21,27,28)(H,23,24,25,26) QYHRIKJPEWGJSY-UHFFFAOYSA-N 262868 3-(1,2,3,4- tetrahydroisoquinolin-6-yl)-2- (1H-tetrazol-5-yl)-6- (trifluoromethyl)benzenesulfon- amide::US9708336, 721 Metallo-beta-lactamase type 2 9.18 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262868 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262868&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823694 376224688 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497761 NS(=O)(=O)c1c(ccc(-c2cccc(c2)C2CCNC2)c1-c1nnn[nH]1)C(F)(F)F 262869 3'-pyrrolidin-3-yl-2-(1H- tetrazol-5-yl)-4- (trifluoromethyl)biphenyl-3- sulfonamide::US9708336, 722 Metallo-beta-lactamase type 2 21.7 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262869 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262869&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823695 376224689 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497764 NS(=O)(=O)c1c(ccc(-c2cccc(c2)N2CCNCC2)c1-c1nnn[nH]1)C(F)(F)F InChI=1S/C18H18F3N7O2S/c19-18(20,21)14-5-4-13(15(16(14)31(22,29)30)17-24-26-27-25-17)11-2-1-3-12(10-11)28-8-6-23-7-9-28/h1-5,10,23H,6-9H2,(H2,22,29,30)(H,24,25,26,27) VOCCOJZAZRHCPQ-UHFFFAOYSA-N 262870 3'-piperazin-1-yl-2-(1H-tetrazol- 5-yl)-4- (trifluoromethyl)biphenyl-3- sulfonamide::US9708336, 723 Metallo-beta-lactamase type 2 17.2 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262870 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262870&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823696 376224690 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497767 NS(=O)(=O)c1c(ccc(-c2cccc3NCCOc23)c1-c1nnn[nH]1)C(F)(F)F InChI=1S/C16H13F3N6O3S/c17-16(18,19)10-5-4-8(9-2-1-3-11-13(9)28-7-6-21-11)12(14(10)29(20,26)27)15-22-24-25-23-15/h1-5,21H,6-7H2,(H2,20,26,27)(H,22,23,24,25) MQFIPHBUSMFBPR-UHFFFAOYSA-N 262871 3-(3,4-dihydro-2H-1,4- benzoxazin-8-yl)-2-(1H-tetrazol- 5-yl)-6- (trifluoromethyl)benzenesulfon- amide::US9708336, 724 Metallo-beta-lactamase type 2 2.44 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262871 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262871&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823697 376224691 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497770 CC(CO)(CO)c1ccc(cc1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)C(F)(F)F InChI=1S/C18H18F3N5O4S/c1-17(8-27,9-28)11-4-2-10(3-5-11)12-6-7-13(18(19,20)21)15(31(22,29)30)14(12)16-23-25-26-24-16/h2-7,27-28H,8-9H2,1H3,(H2,22,29,30)(H,23,24,25,26) HHWDWFDDPBTCCL-UHFFFAOYSA-N 262872 4'-[2-hydroxy-1- (hydroxymethyl)-1- methylethyl]-2-(1H-tetrazol-5- yl)-4-(trifluoromethyl)biphenyl- 3-sulfonamide::US9708336, 725 Metallo-beta-lactamase type 2 0.920 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262872 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262872&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823698 376224692 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497773 CNC1CCc2c1cccc2-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)C(F)(F)F 262873 3-[1-(methylamino)-2,3- dihydro-1H-inden-4-yl]-2-(1H- tetrazol-5-yl)-6- (trifluoromethyl)benzenesulfon- amide::US9708336, 726 Metallo-beta-lactamase type 2 58.9 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262873 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262873&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823699 376224693 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497776 N[C@@H]1CCCN(C1)c1ccc(cc1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)C(F)(F)F 262874 4'-[(3R)-3-aminopiperidin-1-yl]- 2-(1H-tetrazol-5-yl)-4- (trifluoromethyl)biphenyl-3- sulfonamide::US9708336, 727 Metallo-beta-lactamase type 2 1.97 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262874 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262874&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823700 376224694 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497779 NC1(CC(O)C1)c1ccc(cc1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)C(F)(F)F InChI=1S/C18H17F3N6O3S/c19-18(20,21)13-6-5-12(14(15(13)31(23,29)30)16-24-26-27-25-16)9-1-3-10(4-2-9)17(22)7-11(28)8-17/h1-6,11,28H,7-8,22H2,(H2,23,29,30)(H,24,25,26,27) HRBSRFFAVVGXSJ-UHFFFAOYSA-N 262875 4'-(1-amino-3- hydroxycyclobutyl)-2-(1H- tetrazol-5-yl)-4- (trifluoromethyl)biphenyl-3- sulfonamide::US9708336, 728 Metallo-beta-lactamase type 2 4.16 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262875 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262875&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823701 376224695 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497782 NC1(CCCC1)c1ccc(cc1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)C(F)(F)F InChI=1S/C19H19F3N6O2S/c20-19(21,22)14-8-7-13(15(16(14)31(24,29)30)17-25-27-28-26-17)11-3-5-12(6-4-11)18(23)9-1-2-10-18/h3-8H,1-2,9-10,23H2,(H2,24,29,30)(H,25,26,27,28) QXPYYMOAJRGWQA-UHFFFAOYSA-N 262876 4'-(1-aminocyclopentyl)-2-(1H- tetrazol-5-yl)-4- (trifluoromethyl)biphenyl-3- sulfonamide::US9708336, 729 Metallo-beta-lactamase type 2 6.97 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262876 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262876&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823702 376224696 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497785 NC1(CCOC1)c1ccc(cc1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)C(F)(F)F 262877 4'-(3-aminotetrahydrofuran-3- yl)-2-(1H-tetrazol-5-yl)-4- (trifluoromethyl)biphenyl-3- sulfonamide::US9708336, 730 Metallo-beta-lactamase type 2 3.57 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262877 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262877&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823703 376224697 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497788 NC1CCCc2ccc(cc12)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)C(F)(F)F 262878 3-(8-amino-5,6,7,8- tetrahydronaphthalen-2-yl)-2- (1H-tetrazol-5-yl)-6- (trifluoromethyl)benzenesulfon- amide::US9708336, 731 Metallo-beta-lactamase type 2 117 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262878 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262878&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823704 376224698 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496228 CN(C)c1ccc(cn1)-c1ccnc(c1-c1nn[nH]n1)S(N)(=O)=O InChI=1S/C13H14N8O2S/c1-21(2)10-4-3-8(7-16-10)9-5-6-15-13(24(14,22)23)11(9)12-17-19-20-18-12/h3-7H,1-2H3,(H2,14,22,23)(H,17,18,19,20) HUVNEWIMKFHGDN-UHFFFAOYSA-N 262359 6-(dimethylamino)-3'-(2H- tetrazol-5-yl)-[3,4'- bipyridine]-2'-sulfonamide::US9708336, 211 Metallo-beta-lactamase type 2 537 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262359 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262359&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823567 376224186 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496231 NS(=O)(=O)c1nccc(-c2cnc3[nH]ccc3c2)c1-c1nn[nH]n1 InChI=1S/C13H10N8O2S/c14-24(22,23)13-10(12-18-20-21-19-12)9(2-4-16-13)8-5-7-1-3-15-11(7)17-6-8/h1-6H,(H,15,17)(H2,14,22,23)(H,18,19,20,21) RUEUDSPRXSQXFC-UHFFFAOYSA-N 262360 4-(1H-pyrrolo[2,3- b]pyridin-5-yl)-3-(2H- tetrazol-5-yl)pyridine-2- sulfonamide::US9708336, 212 Metallo-beta-lactamase type 2 415 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262360 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262360&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823568 376224187 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496234 NS(=O)(=O)c1nccc(-c2ccc3cccnc3c2)c1-c1nn[nH]n1 InChI=1S/C15H11N7O2S/c16-25(23,24)15-13(14-19-21-22-20-14)11(5-7-18-15)10-4-3-9-2-1-6-17-12(9)8-10/h1-8H,(H2,16,23,24)(H,19,20,21,22) NOPJUODILLONNN-UHFFFAOYSA-N 262361 4-(quinolin-7-yl)-3-(2H- tetrazol-5-yl)pyridine-2- sulfonamide::US9708336, 213 Metallo-beta-lactamase type 2 564 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262361 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262361&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823569 376224188 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496237 CC(=O)Nc1ccc(cc1)-c1ccnc(c1-c1nn[nH]n1)S(N)(=O)=O InChI=1S/C14H13N7O3S/c1-8(22)17-10-4-2-9(3-5-10)11-6-7-16-14(25(15,23)24)12(11)13-18-20-21-19-13/h2-7H,1H3,(H,17,22)(H2,15,23,24)(H,18,19,20,21) ZKIYTWSYOYUPEJ-UHFFFAOYSA-N 262362 N-(4-(2-sulfamoyl-3-(2H- tetrazol-5-yl)pyridin-4- yl)phenyl)acetamide::US9708336, 214 Metallo-beta-lactamase type 2 98.4 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262362 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262362&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823570 376224189 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496240 Nc1ccc(cn1)-c1ccnc(c1-c1nn[nH]n1)S(N)(=O)=O InChI=1S/C11H10N8O2S/c12-8-2-1-6(5-15-8)7-3-4-14-11(22(13,20)21)9(7)10-16-18-19-17-10/h1-5H,(H2,12,15)(H2,13,20,21)(H,16,17,18,19) FONSIYGLYKYCFG-UHFFFAOYSA-N 262363 6-amino-3'-(2H-tetrazol-5- yl)-[3,4'-bipyridine]-2'- sulfonamide::US9708336, 215 Metallo-beta-lactamase type 2 1856 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262363 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262363&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823571 376224190 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496243 Nc1nnc(s1)C1CCN(CC1)c1ccnc(c1-c1nnn[nH]1)S(N)(=O)=O InChI=1S/C13H16N10O2S2/c14-13-20-19-11(26-13)7-2-5-23(6-3-7)8-1-4-16-12(27(15,24)25)9(8)10-17-21-22-18-10/h1,4,7H,2-3,5-6H2,(H2,14,20)(H2,15,24,25)(H,17,18,21,22) ODLFRJBDCXZBNZ-UHFFFAOYSA-N 262364 4-[4-(5-amino-1,3,4- thiadiazol-2-yl)piperidin-1- yl]-3-(1H-tetrazol-5- yl)pyridine-2-sulfonamide::US9708336, 216 Metallo-beta-lactamase type 2 456 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262364 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262364&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266252 376224191 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496246 NS(=O)(=O)c1nccc(N2CCC(CC2)c2ccncc2)c1-c1nnn[nH]1 InChI=1S/C16H18N8O2S/c17-27(25,26)16-14(15-20-22-23-21-15)13(3-8-19-16)24-9-4-12(5-10-24)11-1-6-18-7-2-11/h1-3,6-8,12H,4-5,9-10H2,(H2,17,25,26)(H,20,21,22,23) MCGZPEFZYYIYJO-UHFFFAOYSA-N 262365 4-(4-pyridin-4-ylpiperidin-1- yl)-3-(1H-tetrazol-5- yl)pyridine-2-sulfonamide::US9708336, 217 Metallo-beta-lactamase type 2 481 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262365 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262365&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266256 376224192 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496249 NS(=O)(=O)c1nccc(N2CCC(CC2)c2cccnc2)c1-c1nnn[nH]1 InChI=1S/C16H18N8O2S/c17-27(25,26)16-14(15-20-22-23-21-15)13(3-7-19-16)24-8-4-11(5-9-24)12-2-1-6-18-10-12/h1-3,6-7,10-11H,4-5,8-9H2,(H2,17,25,26)(H,20,21,22,23) LOYRHMWFVMRYGA-UHFFFAOYSA-N 262366 4-(4-pyridin-3-ylpiperidin-1- yl)-3-(1H-tetrazol-5- yl)pyridine-2-sulfonamide::US9708336, 218 Metallo-beta-lactamase type 2 484 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262366 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262366&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266250 376224193 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496252 CN(C)CCC1CCN(CC1)c1ccnc(c1-c1nnn[nH]1)S(N)(=O)=O InChI=1S/C15H24N8O2S/c1-22(2)8-4-11-5-9-23(10-6-11)12-3-7-17-15(26(16,24)25)13(12)14-18-20-21-19-14/h3,7,11H,4-6,8-10H2,1-2H3,(H2,16,24,25)(H,18,19,20,21) JNZPXLJEZSLFRW-UHFFFAOYSA-N 262367 4-{4-[2- (dimethylamino)ethyl]piperidin- 1-yl}-3-(1H-tetrazol-5- yl)pyridine-2-sulfonamide::US9708336, 219 Metallo-beta-lactamase type 2 10410 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262367 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262367&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266259 376224194 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496255 NS(=O)(=O)c1nccc(N2CCCC(C2)c2ccccn2)c1-c1nnn[nH]1 262368 4-(3-pyridin-2-ylpiperidin-1- yl)-3-(1H-tetrazol-5- yl)pyridine-2-sulfonamide::US9708336, 220 Metallo-beta-lactamase type 2 2387 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262368 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262368&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823572 376224195 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496258 NS(=O)(=O)c1nccc(N2CCC3(CC2)NCNC3=O)c1-c1nnn[nH]1 InChI=1S/C13H17N9O3S/c14-26(24,25)11-9(10-18-20-21-19-10)8(1-4-15-11)22-5-2-13(3-6-22)12(23)16-7-17-13/h1,4,17H,2-3,5-7H2,(H,16,23)(H2,14,24,25)(H,18,19,20,21) PSBNMFKBFRRDDW-UHFFFAOYSA-N 262369 4-(4-oxo-1,3,8- triazaspiro[4.5]dec-8-yl)-3- (1H-tetrazol-5-yl)pyridine-2- sulfonamide::US9708336, 221 Metallo-beta-lactamase type 2 6169 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262369 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262369&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266247 376224196 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496261 NS(=O)(=O)c1nccc(N2CCC(CC2)N2CCCC2)c1-c1nnn[nH]1 InChI=1S/C15H22N8O2S/c16-26(24,25)15-13(14-18-20-21-19-14)12(3-6-17-15)23-9-4-11(5-10-23)22-7-1-2-8-22/h3,6,11H,1-2,4-5,7-10H2,(H2,16,24,25)(H,18,19,20,21) VUWXNKSMEUHYPF-UHFFFAOYSA-N 262370 4-(4-pyrrolidin-1-ylpiperidin- 1-yl)-3-(1H-tetrazol-5- yl)pyridine-2-sulfonamide::US9708336, 222 Metallo-beta-lactamase type 2 20000 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262370 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262370&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266151 376224197 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496264 CC(C1CCN(CC1)c1ccnc(c1-c1nnn[nH]1)S(N)(=O)=O)N1CCOCC1 262371 4-[4-(1-morpholin-4- ylethyl)piperidin-1-yl]-3-(1H- tetrazol-5-yl)pyridine-2- sulfonamide::US9708336, 223 Metallo-beta-lactamase type 2 1305 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262371 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262371&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266152 376224198 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496267 NS(=O)(=O)c1nccc(N2CCC(CN3CCOCC3)CC2)c1-c1nnn[nH]1 InChI=1S/C16H24N8O3S/c17-28(25,26)16-14(15-19-21-22-20-15)13(1-4-18-16)24-5-2-12(3-6-24)11-23-7-9-27-10-8-23/h1,4,12H,2-3,5-11H2,(H2,17,25,26)(H,19,20,21,22) AEWRNRLAOOHTMU-UHFFFAOYSA-N 262372 4-[4-(morpholin-4- ylmethyl)piperidin-1-yl]-3- (1H-tetrazol-5-yl)pyridine-2- sulfonamide::US9708336, 224 Metallo-beta-lactamase type 2 1093 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262372 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262372&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266158 376224199 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496270 NS(=O)(=O)c1nccc(N2CCC(CC2)c2cnc3CCCCn23)c1-c1nnn[nH]1 InChI=1S/C18H23N9O2S/c19-30(28,29)18-16(17-22-24-25-23-17)13(4-7-20-18)26-9-5-12(6-10-26)14-11-21-15-3-1-2-8-27(14)15/h4,7,11-12H,1-3,5-6,8-10H2,(H2,19,28,29)(H,22,23,24,25) HWQQCIQEUSPTGO-UHFFFAOYSA-N 262373 4-[4-(5,6,7,8- tetrahydroimidazo[1,2- a]pyridin-3-yl)piperidin-1-yl]- 3-(1H-tetrazol-5-yl)pyridine- 2-sulfonamide::US9708336, 225 Metallo-beta-lactamase type 2 76.2 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262373 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262373&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823573 376224200 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496273 NS(=O)(=O)c1nccc(N2CCC(CC2)N2CC[C@H](O)C2)c1-c1nnn[nH]1 262374 4-{4-[(3S)-3- hydroxypyrrolidin-1- yl]piperidin-1-yl}-3-(1H- tetrazol-5-yl)pyridine-2- sulfonamide::US9708336, 226 Metallo-beta-lactamase type 2 3869 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262374 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262374&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266153 376224201 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496276 NS(=O)(=O)c1nccc(N2CCC(CC2)N2CCNCC2)c1-c1nnn[nH]1 InChI=1S/C15H23N9O2S/c16-27(25,26)15-13(14-19-21-22-20-14)12(1-4-18-15)24-7-2-11(3-8-24)23-9-5-17-6-10-23/h1,4,11,17H,2-3,5-10H2,(H2,16,25,26)(H,19,20,21,22) OBVHZTAPDCBERW-UHFFFAOYSA-N 262375 4-(4-piperazin-1-ylpiperidin- 1-yl)-3-(1H-tetrazol-5- yl)pyridine-2-sulfonamide::US9708336, 227 Metallo-beta-lactamase type 2 7070 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262375 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262375&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266159 376224202 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496279 NS(=O)(=O)c1nccc(N2CCC(CC2)n2ccnc2)c1-c1nnn[nH]1 InChI=1S/C14H17N9O2S/c15-26(24,25)14-12(13-18-20-21-19-13)11(1-4-17-14)22-6-2-10(3-7-22)23-8-5-16-9-23/h1,4-5,8-10H,2-3,6-7H2,(H2,15,24,25)(H,18,19,20,21) BPOAWAZAMPCJJI-UHFFFAOYSA-N 262376 4-[4-(1H-imidazol-1- yl)piperidin-1-yl]-3-(1H- tetrazol-5-yl)pyridine-2- sulfonamide::US9708336, 228 Metallo-beta-lactamase type 2 3207 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262376 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262376&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266242 376224203 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496282 CN(Cc1ccccc1)c1ccnc(c1-c1nnn[nH]1)S(N)(=O)=O InChI=1S/C14H15N7O2S/c1-21(9-10-5-3-2-4-6-10)11-7-8-16-14(24(15,22)23)12(11)13-17-19-20-18-13/h2-8H,9H2,1H3,(H2,15,22,23)(H,17,18,19,20) JIMURVWIUYTHEW-UHFFFAOYSA-N 262377 4-[benzyl(methyl)amino]-3- (1H-tetrazol-5-yl)pyridine-2- sulfonamide::US9708336, 229 Metallo-beta-lactamase type 2 466 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262377 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262377&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266239 376224204 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496285 Cn1cncc1C1CCN(CC1)c1ccnc(c1-c1nnn[nH]1)S(N)(=O)=O InChI=1S/C15H19N9O2S/c1-23-9-17-8-12(23)10-3-6-24(7-4-10)11-2-5-18-15(27(16,25)26)13(11)14-19-21-22-20-14/h2,5,8-10H,3-4,6-7H2,1H3,(H2,16,25,26)(H,19,20,21,22) IORNQKONYWIBRN-UHFFFAOYSA-N 262378 4-[4-(1-methyl-1H-imidazol- 5-yl)piperidin-1-yl]-3-(1H- tetrazol-5-yl)pyridine-2- sulfonamide::US9708336, 230 Metallo-beta-lactamase type 2 797 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262378 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262378&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266064 376224205 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496288 NS(=O)(=O)c1nccc(N2CCC(CC2)Oc2ncccn2)c1-c1nnn[nH]1 InChI=1S/C15H17N9O3S/c16-28(25,26)14-12(13-20-22-23-21-13)11(2-7-17-14)24-8-3-10(4-9-24)27-15-18-5-1-6-19-15/h1-2,5-7,10H,3-4,8-9H2,(H2,16,25,26)(H,20,21,22,23) KEYKAPJDMIRQDF-UHFFFAOYSA-N 262379 4-[4-(pyrimidin-2- yloxy)piperidin-1-yl]-3-(1H- tetrazol-5-yl)pyridine-2- sulfonamide::US9708336, 231 Metallo-beta-lactamase type 2 423 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262379 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262379&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823574 376224206 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496291 CN(C1CCCCC1)c1ccnc(c1-c1nnn[nH]1)S(N)(=O)=O InChI=1S/C13H19N7O2S/c1-20(9-5-3-2-4-6-9)10-7-8-15-13(23(14,21)22)11(10)12-16-18-19-17-12/h7-9H,2-6H2,1H3,(H2,14,21,22)(H,16,17,18,19) KCMJBZSOLRAOTK-UHFFFAOYSA-N 262380 4-[cyclohexyl(methyl)amino]- 3-(1H-tetrazol-5-yl)pyridine- 2-sulfonamide::US9708336, 232 Metallo-beta-lactamase type 2 7638 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262380 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262380&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266065 376224207 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497269 Nc1ncc2cccc(-c3ccc(c(c3-c3nn[nH]n3)S(N)(=O)=O)C(F)(F)F)c2n1 InChI=1S/C16H11F3N8O2S/c17-16(18,19)10-5-4-8(9-3-1-2-7-6-22-15(20)23-12(7)9)11(13(10)30(21,28)29)14-24-26-27-25-14/h1-6H,(H2,20,22,23)(H2,21,28,29)(H,24,25,26,27) JWVLPFWXMOLIRD-UHFFFAOYSA-N 262705 3-(2-aminoquinazolin-8-yl)-2- (2H-tetrazol-5-yl)-6- (trifluoromethyl)benzenesulfon- amide::US9708336, 558 Metallo-beta-lactamase type 2 1.96 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262705 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262705&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266337 376224530 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497272 NS(=O)(=O)c1c(ccc(-c2ccc(cc2)-c2c[nH]c(O)[nH+]2)c1-c1nnn[nH]1)C(F)(F)F InChI=1S/C17H12F3N7O3S/c18-17(19,20)11-6-5-10(13(14(11)31(21,29)30)15-24-26-27-25-15)8-1-3-9(4-2-8)12-7-22-16(28)23-12/h1-7H,(H2,21,29,30)(H2,22,23,28)(H,24,25,26,27)/p+1 FZFFPPHUPXODLR-UHFFFAOYSA-O 262706 3-[4-(2-hydroxy-1H-imidazol- 4-yl)phenyl]-2-(1H-tetrazol-5- yl)-6- (trifluoromethyl)benzenesulfon- amide::US9708336, 559 Metallo-beta-lactamase type 2 0.534 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262706 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262706&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823669 376224531 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497275 Cn1c(N)[nH+]cc1-c1ccc(cc1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)C(F)(F)F InChI=1S/C18H15F3N8O2S/c1-29-13(8-24-17(29)22)10-4-2-9(3-5-10)11-6-7-12(18(19,20)21)15(32(23,30)31)14(11)16-25-27-28-26-16/h2-8H,1H3,(H2,22,24)(H2,23,30,31)(H,25,26,27,28)/p+1 OTNYOQXNSJHTHV-UHFFFAOYSA-O 262707 3-[4-(2-amino-3-methyl- imidazol-4-yl)phenyl]-2-(1H- tetrazol-5-yl)-6- (trifluoromethyl)benzenesulfon- amide::US9708336, 560 Metallo-beta-lactamase type 2 0.898 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262707 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262707&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823671 376224532 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497278 Nc1nc2c(cccc2s1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)C(F)(F)F InChI=1S/C15H10F3N7O2S2/c16-15(17,18)8-5-4-6(7-2-1-3-9-11(7)21-14(19)28-9)10(12(8)29(20,26)27)13-22-24-25-23-13/h1-5H,(H2,19,21)(H2,20,26,27)(H,22,23,24,25) UKIORIWISGQFSR-UHFFFAOYSA-N 262571 3-(2-amino-1,3-benzothiazol-4-yl)-2-(2H-tetrazol-5-yl)-6-(trifluoromethyl)benzenesulfonamide::US9708336, 423::US9708336, 561 Metallo-beta-lactamase type 2 0.993 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262571 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262571&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118257480 376224398 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497281 Nc1ccc(nc1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)C(F)(F)F InChI=1S/C13H10F3N7O2S/c14-13(15,16)8-3-2-7(9-4-1-6(17)5-19-9)10(11(8)26(18,24)25)12-20-22-23-21-12/h1-5H,17H2,(H2,18,24,25)(H,20,21,22,23) XZIMLCBUFQTIAI-UHFFFAOYSA-N 262709 3-(5-aminopyridin-2-yl)-2- (1H-tetrazol-5-yl)-6- (trifluoromethyl)benzenesulfon- amide::US9708336, 562 Metallo-beta-lactamase type 2 7.55 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262709 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262709&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266258 376224533 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497284 NS(=O)(=O)c1c(ccc(-c2ccc(cc2)C(=N)NC2CNC2)c1-c1nn[nH]n1)C(F)(F)F InChI=1S/C18H17F3N8O2S/c19-18(20,21)13-6-5-12(14(15(13)32(23,30)31)17-26-28-29-27-17)9-1-3-10(4-2-9)16(22)25-11-7-24-8-11/h1-6,11,24H,7-8H2,(H2,22,25)(H2,23,30,31)(H,26,27,28,29) DRMSKUZIJAUXPP-UHFFFAOYSA-N 262710 N-(azetidin-3-yl)-3′-sulfamoyl-2′-(2H-tetrazol-5-yl)-4′-(trifluoromethyl)biphenyl-4-carboximidamide::US9708336, 563 Metallo-beta-lactamase type 2 45.9 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262710 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262710&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118256831 376224534 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497287 NS(=O)(=O)c1c(ccc(-c2ccc(cc2)C(=N)NC2CCNC2)c1-c1nn[nH]n1)C(F)(F)F 262711 N-(pyrrolidin-3-yl)-3′-sulfamoyl-2′-(2H-tetrazol-5-yl)-4′-(trifluoromethyl)biphenyl-4-carboximidamide::US9708336, 564 Metallo-beta-lactamase type 2 301 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262711 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262711&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118256857 376224535 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497290 NCCCNC(=N)c1ccc(cc1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)C(F)(F)F InChI=1S/C18H19F3N8O2S/c19-18(20,21)13-7-6-12(14(15(13)32(24,30)31)17-26-28-29-27-17)10-2-4-11(5-3-10)16(23)25-9-1-8-22/h2-7H,1,8-9,22H2,(H2,23,25)(H2,24,30,31)(H,26,27,28,29) UTBHUGJPTAQERL-UHFFFAOYSA-N 262712 N-(3-aminopropyl)-3′-sulfamoyl-2′-(2H-tetrazol-5-yl)-4′-(trifluoromethyl)biphenyl-4-carboximidamide::US9708336, 565 Metallo-beta-lactamase type 2 200 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262712 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262712&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118256942 376224536 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497293 Nc1nc2cc(F)cc(-c3ccc(c(c3-c3nnn[nH]3)S(N)(=O)=O)C(F)(F)F)c2[nH]1 InChI=1S/C15H10F4N8O2S/c16-5-3-7(11-9(4-5)22-14(20)23-11)6-1-2-8(15(17,18)19)12(30(21,28)29)10(6)13-24-26-27-25-13/h1-4H,(H3,20,22,23)(H2,21,28,29)(H,24,25,26,27) GWIQLGMGLUTRQS-UHFFFAOYSA-N 262713 3-(2-amino-5-fluoro-1H-benzo[d]imidazol-7-yl)-2-(1H-tetrazol-5-yl)-6-(trifluoromethyl)benzenesulfonamide::US9708336, 566 Metallo-beta-lactamase type 2 2.68 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262713 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262713&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118257228 376224537 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497296 Nc1nc2cc(cc(-c3ccc(c(c3-c3nnn[nH]3)S(N)(=O)=O)C(F)(F)F)c2[nH]1)C(F)(F)F InChI=1S/C16H10F6N8O2S/c17-15(18,19)5-3-7(11-9(4-5)25-14(23)26-11)6-1-2-8(16(20,21)22)12(33(24,31)32)10(6)13-27-29-30-28-13/h1-4H,(H3,23,25,26)(H2,24,31,32)(H,27,28,29,30) PLWBOUDBBLRWPF-UHFFFAOYSA-N 262714 3-(2-amino-5-(trifluoromethyl)-1H-benzo[d]imidazol-7-yl)-N,N-bis(4-methoxybenzyl)-2-(2-(4-methoxybenzyl)-2H-tetrazol-5-yl)-6-(trifluoromethyl) benzenesulfonamide::US9708336, 567 Metallo-beta-lactamase type 2 3.77 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262714 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262714&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266302 376224538 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497299 Cc1ccc(-c2ccc(c(c2-c2nnn[nH]2)S(N)(=O)=O)C(F)(F)F)c2[nH]c(N)nc12 InChI=1S/C16H13F3N8O2S/c1-6-2-3-8(12-11(6)22-15(20)23-12)7-4-5-9(16(17,18)19)13(30(21,28)29)10(7)14-24-26-27-25-14/h2-5H,1H3,(H3,20,22,23)(H2,21,28,29)(H,24,25,26,27) QJYZXCLZGZROIV-UHFFFAOYSA-N 262715 3-(2-amino-4-methyl-1H-benzo[d]imidazol-7-yl)-2-(1H-tetrazol-5-yl)-6-(trifluoromethyl)benzenesulfonamide::US9708336, 568 Metallo-beta-lactamase type 2 1.17 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262715 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262715&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118257024 376224539 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497302 Nc1nc2cc(cc(-c3ccc(c(c3-c3nnn[nH]3)S(N)(=O)=O)C(F)(F)F)c2[nH]1)C#N InChI=1S/C16H10F3N9O2S/c17-16(18,19)9-2-1-7(11(13(9)31(22,29)30)14-25-27-28-26-14)8-3-6(5-20)4-10-12(8)24-15(21)23-10/h1-4H,(H3,21,23,24)(H2,22,29,30)(H,25,26,27,28) SECAMMOGAWOMEA-UHFFFAOYSA-N 262716 3-(2-amino-5-cyano-1H-benzo[d]imidazol-7-yl)-2-(1H-tetrazol-5-yl)-6-(trifluoromethyl)benzenesulfonamide::US9708336, 569 Metallo-beta-lactamase type 2 1.62 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262716 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262716&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118257172 376224540 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497305 Nc1nc2nccc(-c3ccc(c(c3-c3nnn[nH]3)S(N)(=O)=O)C(F)(F)F)c2[nH]1 InChI=1S/C14H10F3N9O2S/c15-14(16,17)7-2-1-5(6-3-4-20-12-9(6)21-13(18)22-12)8(10(7)29(19,27)28)11-23-25-26-24-11/h1-4H,(H2,19,27,28)(H3,18,20,21,22)(H,23,24,25,26) MUVOMQQQMNGNCZ-UHFFFAOYSA-N 262717 3-(2-amino-1H-imidazo[4,5-b]pyridin-7-yl)-2-(1H-tetrazol-5-yl)-6-(trifluoromethyl)benzenesulfonamide::US9708336, 570 Metallo-beta-lactamase type 2 4.06 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262717 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262717&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118256964 376224541 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497308 Nc1nc2cncc(-c3ccc(c(c3-c3nnn[nH]3)S(N)(=O)=O)C(F)(F)F)c2[nH]1 InChI=1S/C14H10F3N9O2S/c15-14(16,17)7-2-1-5(6-3-20-4-8-10(6)22-13(18)21-8)9(11(7)29(19,27)28)12-23-25-26-24-12/h1-4H,(H3,18,21,22)(H2,19,27,28)(H,23,24,25,26) LRIDIAGCBNSRNV-UHFFFAOYSA-N 262718 3-(2-amino-1H-imidazo[4,5-c]pyridin-7-yl)-2-(1H-tetrazol-5-yl)-6-(trifluoromethyl)benzenesulfonamide::US9708336, 571 Metallo-beta-lactamase type 2 14.8 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262718 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262718&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266367 376224542 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497311 Cc1nc(N)ccc1Cc1cccc(c1-c1nn[nH]n1)S(N)(=O)=O InChI=1S/C14H15N7O2S/c1-8-9(5-6-12(15)17-8)7-10-3-2-4-11(24(16,22)23)13(10)14-18-20-21-19-14/h2-6H,7H2,1H3,(H2,15,17)(H2,16,22,23)(H,18,19,20,21) MYQIVNBMWINVGM-UHFFFAOYSA-N 262719 3-((6-amino-2-methylpyridin-3-yl)methyl)-2-(2H-tetrazol-5-yl)benzenesulfonamide::US9708336, 572 Metallo-beta-lactamase type 2 701 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262719 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262719&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118256974 376224543 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497314 Cc1cc(N)ncc1Cc1cccc(c1-c1nn[nH]n1)S(N)(=O)=O InChI=1S/C14H15N7O2S/c1-8-5-12(15)17-7-10(8)6-9-3-2-4-11(24(16,22)23)13(9)14-18-20-21-19-14/h2-5,7H,6H2,1H3,(H2,15,17)(H2,16,22,23)(H,18,19,20,21) HTENIEZINREWHQ-UHFFFAOYSA-N 262720 3-((6-amino-4-methylpyridin-3-yl)methyl)-2-(2H-tetrazol-5-yl)benzenesulfonamide::US9708336, 573 Metallo-beta-lactamase type 2 668 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262720 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262720&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118256973 376224544 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497317 N[C@H]1CC[C@@H](Cc2ccc(-c3ccc(N)nc3)c(-c3nnn[nH]3)c2S(N)(=O)=O)CC1 262721 6-(((1s,4s)-4-aminocyclohexyl)methyl)-3-(6-aminopyridin-3-yl)-2-(2H-tetrazol-5-yl)benzenesulfonamide::US9708336, 574 Metallo-beta-lactamase type 2 35.9 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262721 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262721&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266265 376224545 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497320 N[C@H]1CC[C@H](Cc2ccc(-c3ccc(N)nc3)c(-c3nnn[nH]3)c2S(N)(=O)=O)CC1 262722 6-(((1r,4r)-4- aminocyclohexyl)methyl)-3-(6- aminopyridin-3-yl)-2-(1H- tetrazol-5-yl)benzenesulfonamide::US9708336, 575 Metallo-beta-lactamase type 2 59.5 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262722 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262722&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266265 376224546 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497323 Nc1ccc(cn1)-c1ccc(CC2CCNCC2)c(c1-c1nnn[nH]1)S(N)(=O)=O InChI=1S/C18H22N8O2S/c19-15-4-2-13(10-22-15)14-3-1-12(9-11-5-7-21-8-6-11)17(29(20,27)28)16(14)18-23-25-26-24-18/h1-4,10-11,21H,5-9H2,(H2,19,22)(H2,20,27,28)(H,23,24,25,26) ASWFMIGVWSBZCA-UHFFFAOYSA-N 262723 3-(6-amino-3-pyridyl)-6-(4- piperidylmethyl)-2-(1H-tetrazol- 5-yl)benzenesulfonamide::US9708336, 576 Metallo-beta-lactamase type 2 164 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262723 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262723&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266264 376224547 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497326 N[C@H]1CC[C@H](CCc2ccc(-c3ccc(N)nc3)c(-c3nnn[nH]3)c2S(N)(=O)=O)CC1 262724 6-(2-((1r,4s)-4- aminocyclohexyl)ethyl)-3-(6- aminopyridin-3-yl)-2-(1H- tetrazol-5-yl)benzenesulfonamide::US9708336, 577 Metallo-beta-lactamase type 2 29.6 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262724 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262724&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266266 376224548 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497329 N[C@H]1CC[C@@H](CCc2ccc(-c3ccc(N)nc3)c(-c3nnn[nH]3)c2S(N)(=O)=O)CC1 262725 6-(2-((1s,4r)-4- aminocyclohexyl)ethyl)-3-(6- aminopyridin-3-yl)-2-(1H- tetrazol-5-yl)benzenesulfonamide::US9708336, 578 Metallo-beta-lactamase type 2 47.1 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262725 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262725&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266266 376224549 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497791 Nc1nc(cs1)-c1ccc(cc1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)C(F)(F)F InChI=1S/C17H12F3N7O2S2/c18-17(19,20)11-6-5-10(13(14(11)31(22,28)29)15-24-26-27-25-15)8-1-3-9(4-2-8)12-7-30-16(21)23-12/h1-7H,(H2,21,23)(H2,22,28,29)(H,24,25,26,27) DILTUSQMKOCARW-UHFFFAOYSA-N 262879 4'-(2-amino-1,3-thiaozl-4-yl)-2- (1H-tetrazol-5-yl)-4- (trifluoromethyl)biphenyl-3- sulfonamide::US9708336, 732 Metallo-beta-lactamase type 2 0.384 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262879 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262879&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823705 376224699 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497794 NCC1COc2ccc(cc12)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)C(F)(F)F 262880 3-[3-(aminomethyl)-2,3- dihydro-1-benzofuran-5-yl]-2- (1H-tetrazol-5-yl)-6- (trifluoromethyl)benzenesulfon- amide::US9708336, 733 Metallo-beta-lactamase type 2 34.3 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262880&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823706 376224700 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497797 NCCc1cccc(c1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)C(F)(F)F InChI=1S/C16H15F3N6O2S/c17-16(18,19)12-5-4-11(10-3-1-2-9(8-10)6-7-20)13(14(12)28(21,26)27)15-22-24-25-23-15/h1-5,8H,6-7,20H2,(H2,21,26,27)(H,22,23,24,25) YMBLPLXXWOGLAR-UHFFFAOYSA-N 262881 3'-(2-aminoethyl)-2-(1H- tetraozl-5-yl)-4- (trifluoromethyl)biphenyl-3- sulfonamide::US9708336, 734 Metallo-beta-lactamase type 2 34.4 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262881 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262881&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823707 376224701 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497800 NCCCc1ccc(cc1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)C(F)(F)F InChI=1S/C17H17F3N6O2S/c18-17(19,20)13-8-7-12(11-5-3-10(4-6-11)2-1-9-21)14(15(13)29(22,27)28)16-23-25-26-24-16/h3-8H,1-2,9,21H2,(H2,22,27,28)(H,23,24,25,26) OHKZNDHULZZGHC-UHFFFAOYSA-N 262882 4'-(3-aminopropyl)-2-(1H- tetrazol-5-yl)-4- (trifluoromethyl)biphenyl-3- sulfonamide::US9708336, 735 Metallo-beta-lactamase type 2 1.70 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262882 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262882&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823708 376224702 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497803 NCCS(=O)(=O)c1ccc(cc1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)C(F)(F)F InChI=1S/C16H15F3N6O4S2/c17-16(18,19)12-6-5-11(9-1-3-10(4-2-9)30(26,27)8-7-20)13(14(12)31(21,28)29)15-22-24-25-23-15/h1-6H,7-8,20H2,(H2,21,28,29)(H,22,23,24,25) XDMCNLNFCWKMCM-UHFFFAOYSA-N 262883 4'-[(2-aminoethyl)sulfonyl]-2- (1H-tetrazol-5-yl)-4- (trifluoromethyl)biphenyl-3- sulfonamide::US9708336, 736 Metallo-beta-lactamase type 2 3.23 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262883 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262883&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823709 376224703 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497806 NS(=O)(=O)Cc1cccc(c1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)C(F)(F)F InChI=1S/C15H13F3N6O4S2/c16-15(17,18)11-5-4-10(9-3-1-2-8(6-9)7-29(19,25)26)12(13(11)30(20,27)28)14-21-23-24-22-14/h1-6H,7H2,(H2,19,25,26)(H2,20,27,28)(H,21,22,23,24) OXZZLVCZDXEABP-UHFFFAOYSA-N 262884 3'-(sulfamoylmethyl)-2-(1H- tetrazol-5-yl)-4- (trifluoromethyl)biphenyl-3- sulfonamide::US9708336, 737 Metallo-beta-lactamase type 2 3.02 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262884 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262884&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823710 376224704 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497809 NS(=O)(=O)c1c(ccc(-c2ccc(cc2)C(O)C2CCNCC2)c1-c1nnn[nH]1)C(F)(F)F 262885 4'-[hydroxy(piperidin-4- yl)methyl]-2-(1H-tetrazol-5-yl)- 4-(trifluoromethyl)biphenyl-3- sulfonamide::US9708336, 738 Metallo-beta-lactamase type 2 2.28 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262885 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262885&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823711 376224705 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497812 NS(=O)(=O)c1c(ccc(-c2cccc(c2)N2CCCC(O)C2)c1-c1nnn[nH]1)C(F)(F)F 262886 3'-(3-hydroxypiperidin-1-yl)-2- (1H-tetrazol-5-yl)-4- (trifluoromethyl)biphenyl-3- sulfonamide::US9708336, 739 Metallo-beta-lactamase type 2 6.82 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262886 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262886&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823712 376224706 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497815 NS(=O)(=O)c1c(ccc(-c2ccc(cc2)N2CCC(O)CC2)c1-c1nnn[nH]1)C(F)(F)F InChI=1S/C19H19F3N6O3S/c20-19(21,22)15-6-5-14(16(17(15)32(23,30)31)18-24-26-27-25-18)11-1-3-12(4-2-11)28-9-7-13(29)8-10-28/h1-6,13,29H,7-10H2,(H2,23,30,31)(H,24,25,26,27) JNDDJNAYNOSVPP-UHFFFAOYSA-N 262887 4'-(4-hydroxypiperidin-1-yl)-2- (1H-tetrazol-5-yl)-4- (trifluoromethyl)biphenyl-3- sulfonamide::US9708336, 740 Metallo-beta-lactamase type 2 0.456 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262887 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262887&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823713 376224707 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497818 NS(=O)(=O)c1c(ccc(-c2cccc(c2)N2CCC(O)CC2)c1-c1nnn[nH]1)C(F)(F)F InChI=1S/C19H19F3N6O3S/c20-19(21,22)15-5-4-14(16(17(15)32(23,30)31)18-24-26-27-25-18)11-2-1-3-12(10-11)28-8-6-13(29)7-9-28/h1-5,10,13,29H,6-9H2,(H2,23,30,31)(H,24,25,26,27) XDUSAFKHNABYND-UHFFFAOYSA-N 262888 3'-(4-hydroxypiperidin-1-yl)-2- (1H-tetrazol-5-yl)-4- (trifluoromethyl)biphenyl-3- sulfonamide::US9708336, 741 Metallo-beta-lactamase type 2 6.12 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262888 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262888&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823714 376224708 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497821 NS(=O)(=O)c1c(ccc(-c2ccc(cc2)S(=O)(=O)CCO)c1-c1nnn[nH]1)C(F)(F)F InChI=1S/C16H14F3N5O5S2/c17-16(18,19)12-6-5-11(9-1-3-10(4-2-9)30(26,27)8-7-25)13(14(12)31(20,28)29)15-21-23-24-22-15/h1-6,25H,7-8H2,(H2,20,28,29)(H,21,22,23,24) YUJHKDIBNVPXKF-UHFFFAOYSA-N 262889 4'-[(2-hydroxyethyl)sulfonyl]-2- (1H-tetrazol-5-yl)-4- (trifluoromethyl)biphenyl-3- sulfonamide::US9708336, 742 Metallo-beta-lactamase type 2 1.84 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262889 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262889&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823715 376224709 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497824 Nc1nc2c(F)cc(cc2s1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)C(F)(F)F InChI=1S/C15H9F4N7O2S2/c16-8-3-5(4-9-11(8)22-14(20)29-9)6-1-2-7(15(17,18)19)12(30(21,27)28)10(6)13-23-25-26-24-13/h1-4H,(H2,20,22)(H2,21,27,28)(H,23,24,25,26) HLEHXKLGZMOEAM-UHFFFAOYSA-N 262890 3-(2-amino-4-fluoro-1,3- benzothiazol-6-yl)-2-(1H- tetrazol-5-yl)-6- (trifluoromethyl)benzenesulfon- amide::US9708336, 743 Metallo-beta-lactamase type 2 0.901 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262890 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262890&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823716 376224710 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497827 NS(=O)(=O)c1c(ccc(-c2ccc(nc2)C2CCNCC2)c1-c1nnn[nH]1)C(F)(F)F InChI=1S/C18H18F3N7O2S/c19-18(20,21)13-3-2-12(15(16(13)31(22,29)30)17-25-27-28-26-17)11-1-4-14(24-9-11)10-5-7-23-8-6-10/h1-4,9-10,23H,5-8H2,(H2,22,29,30)(H,25,26,27,28) YWWMNOFOKCGGLY-UHFFFAOYSA-N 262891 3-(6-piperidin-4-ylpyridin-3-yl)- 2-(1H-tetrazol-5-yl)-6- (trifluoromethyl)benzenesulfon- amide::US9708336, 744 Metallo-beta-lactamase type 2 18.1 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262891 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262891&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823717 376224711 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497830 Nc1ccc2cc(ccc2n1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)C(F)(F)F InChI=1S/C17H12F3N7O2S/c18-17(19,20)11-4-3-10(8-1-5-12-9(7-8)2-6-13(21)23-12)14(15(11)30(22,28)29)16-24-26-27-25-16/h1-7H,(H2,21,23)(H2,22,28,29)(H,24,25,26,27) WXPRMZMSIYKNJX-UHFFFAOYSA-N 262892 3-(2-aminoquinolin-6-yl)-2-(1H- tetrazol-5-yl)-6- (trifluoromethyl)benzenesulfon- amide::US9708336, 745 Metallo-beta-lactamase type 2 1.50 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262892 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262892&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823718 376224712 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497833 NS(=O)(=O)c1c(ccc(-c2ccc3C(=O)NCc3c2)c1-c1nnn[nH]1)C(F)(F)F InChI=1S/C16H11F3N6O3S/c17-16(18,19)11-4-3-9(7-1-2-10-8(5-7)6-21-15(10)26)12(13(11)29(20,27)28)14-22-24-25-23-14/h1-5H,6H2,(H,21,26)(H2,20,27,28)(H,22,23,24,25) TVSTZOKLCKKQGL-UHFFFAOYSA-N 262893 3-(1-oxo-2,3-dihydro-1H- isoindol-5-yl)-2-(1H-tetrazol-5- yl)-6- (trifluoromethyl)benzenesulfon- amide::US9708336, 746 Metallo-beta-lactamase type 2 2.59 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262893 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262893&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823719 376224713 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497836 Cc1ccncc1-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)C(F)(F)F InChI=1S/C14H11F3N6O2S/c1-7-4-5-19-6-9(7)8-2-3-10(14(15,16)17)12(26(18,24)25)11(8)13-20-22-23-21-13/h2-6H,1H3,(H2,18,24,25)(H,20,21,22,23) PLDGJTPXMQVGLL-UHFFFAOYSA-N 262894 3-(4-methylpyridin-3-yl)-2-(1H- tetrazol-5-yl)-6- (trifluoromethyl)benzenesulfon- amide::US9708336, 747 Metallo-beta-lactamase type 2 11.2 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262894 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262894&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823720 376224714 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497839 NS(=O)(=O)c1c(ccc(-c2cnc3ccccn23)c1-c1nnn[nH]1)C(F)(F)F InChI=1S/C15H10F3N7O2S/c16-15(17,18)9-5-4-8(10-7-20-11-3-1-2-6-25(10)11)12(13(9)28(19,26)27)14-21-23-24-22-14/h1-7H,(H2,19,26,27)(H,21,22,23,24) OCKZNORKGXWEQR-UHFFFAOYSA-N 262895 3-imidazo[1,2-a]pyridin-3-yl-2- (1H-tetrazol-5-yl)-6- (trifluoromethyl)benzenesulfon- amide::US9708336, 748 Metallo-beta-lactamase type 2 1.25 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262895 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262895&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823721 376224715 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497842 Nc1ncnc2cc(ccc12)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)C(F)(F)F InChI=1S/C16H11F3N8O2S/c17-16(18,19)10-4-3-8(7-1-2-9-11(5-7)22-6-23-14(9)20)12(13(10)30(21,28)29)15-24-26-27-25-15/h1-6H,(H2,20,22,23)(H2,21,28,29)(H,24,25,26,27) SEIWHIHGDQMYMK-UHFFFAOYSA-N 262896 3-(4-aminoquinazolin-7-yl)-2- (1H-tetrazol-5-yl)-6- (trifluoromethyl)benzenesulfon- amide::US9708336, 749 Metallo-beta-lactamase type 2 4.12 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262896 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262896&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823722 376224716 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497845 Nc1nc(N)c2ccc(cc2n1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)C(F)(F)F InChI=1S/C16H12F3N9O2S/c17-16(18,19)9-4-3-7(11(12(9)31(22,29)30)14-25-27-28-26-14)6-1-2-8-10(5-6)23-15(21)24-13(8)20/h1-5H,(H2,22,29,30)(H4,20,21,23,24)(H,25,26,27,28) IAEHBIYCTDUVSF-UHFFFAOYSA-N 262897 3-(2,4-diaminoquinazolin-7-yl)- 2-(1H-tetrazol-5-yl)-6- (trifluoromethyl)benzenesulfon- amide::US9708336, 750 Metallo-beta-lactamase type 2 21.5 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262897 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262897&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823723 376224717 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497848 Nc1nccc2cc(ccc12)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)C(F)(F)F InChI=1S/C17H12F3N7O2S/c18-17(19,20)12-4-3-10(8-1-2-11-9(7-8)5-6-23-15(11)21)13(14(12)30(22,28)29)16-24-26-27-25-16/h1-7H,(H2,21,23)(H2,22,28,29)(H,24,25,26,27) BWHGDTOENFYXHZ-UHFFFAOYSA-N 262898 3-(1-aminoisoquinolin-6-yl)-2- (1H-tetrazol-5-yl)-6- (trifluoromethyl)benzenesulfon- amide::US9708336, 751 Metallo-beta-lactamase type 2 5.63 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262898 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262898&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823724 376224718 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497851 CCn1c(N)nc2cc(ccc12)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)C(F)(F)F InChI=1S/C17H15F3N8O2S/c1-2-28-12-6-3-8(7-11(12)23-16(28)21)9-4-5-10(17(18,19)20)14(31(22,29)30)13(9)15-24-26-27-25-15/h3-7H,2H2,1H3,(H2,21,23)(H2,22,29,30)(H,24,25,26,27) SANXUYVYEZSZPR-UHFFFAOYSA-N 262899 3-(2-amino-1-ethyl-1H- benzimidazol-5-yl)-2-(1H- tetrazol-5-yl)-6- (trifluoromethyl)benzenesulfon- amide::US9708336, 752 Metallo-beta-lactamase type 2 6.25 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262899 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262899&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823725 376224719 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496294 NS(=O)(=O)c1nccc(N2CCC(Cn3ccnc3)CC2)c1-c1nnn[nH]1 InChI=1S/C15H19N9O2S/c16-27(25,26)15-13(14-19-21-22-20-14)12(1-4-18-15)24-6-2-11(3-7-24)9-23-8-5-17-10-23/h1,4-5,8,10-11H,2-3,6-7,9H2,(H2,16,25,26)(H,19,20,21,22) UOJNBJKZWZGEAX-UHFFFAOYSA-N 262381 4-[4-(1H-imidazol-1- ylmethyl)piperidin-1-yl]-3- (1H-tetrazol-5-yl)pyridine-2- sulfonamide::US9708336, 233 Metallo-beta-lactamase type 2 195 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262381 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262381&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266089 376224208 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496297 NS(=O)(=O)c1nccc(NC2CCCCC2)c1-c1nnn[nH]1 InChI=1S/C12H17N7O2S/c13-22(20,21)12-10(11-16-18-19-17-11)9(6-7-14-12)15-8-4-2-1-3-5-8/h6-8H,1-5H2,(H,14,15)(H2,13,20,21)(H,16,17,18,19) PBDPLYDSGUXSNA-UHFFFAOYSA-N 262382 4-(cyclohexylamino)-3-(1H- tetrazol-5-yl)pyridine-2- sulfonamide::US9708336, 234 Metallo-beta-lactamase type 2 1448 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262382 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262382&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266067 376224209 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496300 NS(=O)(=O)c1nccc(NCc2ccccc2)c1-c1nnn[nH]1 InChI=1S/C13H13N7O2S/c14-23(21,22)13-11(12-17-19-20-18-12)10(6-7-15-13)16-8-9-4-2-1-3-5-9/h1-7H,8H2,(H,15,16)(H2,14,21,22)(H,17,18,19,20) FKGPWFRZBWONFT-UHFFFAOYSA-N 262383 4-(benzylamino)-3-(1H- tetrazol-5-yl)pyridine-2- sulfonamide::US9708336, 235 Metallo-beta-lactamase type 2 3435 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262383 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262383&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823575 376224210 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496303 NS(=O)(=O)c1nccc(NCCC2CCCCC2)c1-c1nnn[nH]1 InChI=1S/C14H21N7O2S/c15-24(22,23)14-12(13-18-20-21-19-13)11(7-9-17-14)16-8-6-10-4-2-1-3-5-10/h7,9-10H,1-6,8H2,(H,16,17)(H2,15,22,23)(H,18,19,20,21) KUSIUUZQRHZIDM-UHFFFAOYSA-N 262384 4-[(2-cyclohexylethyl)amino]- 3-(1H-tetrazol-5-yl)pyridine- 2-sulfonamide::US9708336, 236 Metallo-beta-lactamase type 2 223 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262384 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262384&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266120 376224211 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496306 NS(=O)(=O)c1nccc(NCCc2ccccc2)c1-c1nnn[nH]1 InChI=1S/C14H15N7O2S/c15-24(22,23)14-12(13-18-20-21-19-13)11(7-9-17-14)16-8-6-10-4-2-1-3-5-10/h1-5,7,9H,6,8H2,(H,16,17)(H2,15,22,23)(H,18,19,20,21) WNNGHLLVVCRYSR-UHFFFAOYSA-N 262385 4-[(2-phenylethyl)amino]-3- (1H-tetrazol-5-yl)pyridine-2- sulfonamide::US9708336, 237 Metallo-beta-lactamase type 2 581 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262385 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262385&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823576 376224212 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496309 NS(=O)(=O)c1nccc(N2CCC(Cc3ccncc3)CC2)c1-c1nnn[nH]1 InChI=1S/C17H20N8O2S/c18-28(26,27)17-15(16-21-23-24-22-16)14(3-8-20-17)25-9-4-13(5-10-25)11-12-1-6-19-7-2-12/h1-3,6-8,13H,4-5,9-11H2,(H2,18,26,27)(H,21,22,23,24) NTMPIIBYBWAINF-UHFFFAOYSA-N 262386 4-[4-(pyridin-4- ylmethyl)piperidin-1-yl]-3- (1H-tetrazol-5-yl)pyridine-2- sulfonamide::US9708336, 238 Metallo-beta-lactamase type 2 188 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262386 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262386&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266093 376224213 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496312 NS(=O)(=O)c1nccc(N2CCC(CC2)N2CCOCC2)c1-c1nnn[nH]1 InChI=1S/C15H22N8O3S/c16-27(24,25)15-13(14-18-20-21-19-14)12(1-4-17-15)23-5-2-11(3-6-23)22-7-9-26-10-8-22/h1,4,11H,2-3,5-10H2,(H2,16,24,25)(H,18,19,20,21) RNNTWJCAOPNFNY-UHFFFAOYSA-N 262387 4-(4-morpholin-4-ylpiperidin- 1-yl)-3-(1H-tetrazol-5- yl)pyridine-2-sulfonamide::US9708336, 239 Metallo-beta-lactamase type 2 3711 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262387 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262387&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266070 376224214 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496315 NS(=O)(=O)c1nccc(N2CCC(CC2)c2ncc[nH]2)c1-c1nnn[nH]1 InChI=1S/C14H17N9O2S/c15-26(24,25)14-11(13-19-21-22-20-13)10(1-4-18-14)23-7-2-9(3-8-23)12-16-5-6-17-12/h1,4-6,9H,2-3,7-8H2,(H,16,17)(H2,15,24,25)(H,19,20,21,22) YIXDYFRNEIJDDC-UHFFFAOYSA-N 262388 4-[4-(1H-imidazol-2- yl)piperidin-1-yl]-3-(1H- tetrazol-5-yl)pyridine-2- sulfonamide::US9708336, 240 Metallo-beta-lactamase type 2 3406 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262388 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262388&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823577 376224215 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496318 NS(=O)(=O)c1nccc(N2CCC(CC2)c2nnc3ccccn23)c1-c1nnc[nH]1 InChI=1S/C18H19N9O2S/c19-30(28,29)18-15(16-21-11-22-24-16)13(4-7-20-18)26-9-5-12(6-10-26)17-25-23-14-3-1-2-8-27(14)17/h1-4,7-8,11-12H,5-6,9-10H2,(H2,19,28,29)(H,21,22,24) HUAMUYDAHINRCC-UHFFFAOYSA-N 262389 3-(1H-tetrazol-5-yl)-4-(4- [1,2,4]triazolo[4,3-a]pyridin- 3-ylpiperidin-1-yl)pyridine-2- sulfonamide::US9708336, 241 Metallo-beta-lactamase type 2 335 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262389 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262389&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 122694027 376224216 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496321 NS(=O)(=O)c1nccc(N2CCC(O)CC2)c1-c1nnn[nH]1 InChI=1S/C11H15N7O3S/c12-22(20,21)11-9(10-14-16-17-15-10)8(1-4-13-11)18-5-2-7(19)3-6-18/h1,4,7,19H,2-3,5-6H2,(H2,12,20,21)(H,14,15,16,17) TZKKMSMZYMBICL-UHFFFAOYSA-N 262390 4-(4-hydroxypiperidin-1-yl)- 3-(1H-tetrazol-5-yl)pyridine- 2-sulfonamide::US9708336, 242 Metallo-beta-lactamase type 2 1115 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262390 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262390&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266125 376224217 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496324 NS(=O)(=O)c1nccc(N2CCCC(Cc3cccnc3)C2)c1-c1nnn[nH]1 262391 4-[3-(pyridin-3- ylmethyl)piperidin-1-yl]-3- (1H-tetrazol-5-yl)pyridine-2- sulfonamide::US9708336, 243 Metallo-beta-lactamase type 2 1509 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262391 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262391&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823578 376224218 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496327 CC(O)C1CCN(CC1)c1ccnc(c1-c1nnn[nH]1)S(N)(=O)=O 262392 4-[4-(1- hydroxyethyl)piperidin-1-yl]- 3-(1H-tetrazol-5-yl)pyridine- 2-sulfonamide::US9708336, 244 Metallo-beta-lactamase type 2 682 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262392 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262392&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266079 376224219 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496330 NS(=O)(=O)c1nccc(N2CCC3(CCNCC3)CC2)c1-c1nn[nH]n1 InChI=1S/C15H22N8O2S/c16-26(24,25)14-12(13-19-21-22-20-13)11(1-6-18-14)23-9-4-15(5-10-23)2-7-17-8-3-15/h1,6,17H,2-5,7-10H2,(H2,16,24,25)(H,19,20,21,22) BQHVCLQUAMZPHC-UHFFFAOYSA-N 262393 4-(3,9-diazaspiro[5.5]undecan-3-yl)-3-(2H-tetrazol-5-yl)pyridine-2-sulfonamide::US9708336, 245 Metallo-beta-lactamase type 2 9779 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262393 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262393&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118256754 376224220 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496333 NS(=O)(=O)c1nccc(c1-c1nn[nH]n1)-n1cnc2ccccc12 InChI=1S/C13H10N8O2S/c14-24(22,23)13-11(12-17-19-20-18-12)10(5-6-15-13)21-7-16-8-3-1-2-4-9(8)21/h1-7H,(H2,14,22,23)(H,17,18,19,20) UIINXCAIRIECNP-UHFFFAOYSA-N 262394 4-(1H-benzo[d]imidazol-1-yl)-3-(2H-tetrazol-5-yl)pyridine-2-sulfonamide::US9708336, 246 Metallo-beta-lactamase type 2 2805 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262394 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262394&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823579 376224221 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496336 NS(=O)(=O)c1cccc(-c2ccn3cncc3c2)c1-c1nn[nH]n1 InChI=1S/C14H11N7O2S/c15-24(22,23)12-3-1-2-11(13(12)14-17-19-20-18-14)9-4-5-21-8-16-7-10(21)6-9/h1-8H,(H2,15,22,23)(H,17,18,19,20) HRQLQDRPKAITER-UHFFFAOYSA-N 262395 3-(Imidazo[1,5-a]pyridin-7-yl)-2-(2H-tetrazol-5-yl)benzenesulfonamide::US9708336, 247 Metallo-beta-lactamase type 2 479 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262395 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262395&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118257351 376224222 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496339 Cc1cnc(cn1)-c1cccc(c1-c1nn[nH]n1)S(N)(=O)=O InChI=1S/C12H11N7O2S/c1-7-5-15-9(6-14-7)8-3-2-4-10(22(13,20)21)11(8)12-16-18-19-17-12/h2-6H,1H3,(H2,13,20,21)(H,16,17,18,19) RWSYREXACTWOFP-UHFFFAOYSA-N 262396 3-(5-Methylpyrazin-2-yl)-2-(2H-tetrazol-5-yl)benzenesulfonamide::US9708336, 248 Metallo-beta-lactamase type 2 134 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262396 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262396&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823580 376224223 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496342 NCc1nc(no1)-c1ccc(cc1)-c1cccc(c1-c1nn[nH]n1)S(N)(=O)=O InChI=1S/C16H14N8O3S/c17-8-13-19-15(22-27-13)10-6-4-9(5-7-10)11-2-1-3-12(28(18,25)26)14(11)16-20-23-24-21-16/h1-7H,8,17H2,(H2,18,25,26)(H,20,21,23,24) GYJXNXLBEVBXNO-UHFFFAOYSA-N 262397 4′-(5-(Aminomethyl)-1,2,4-oxadiazol-3-yl)-2-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-3-sulfonamide::US9708336, 249 Metallo-beta-lactamase type 2 104 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262397 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262397&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823581 376224224 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496345 NS(=O)(=O)c1cccc(-c2ccc(cc2)-c2noc(n2)C2CCNC2)c1-c1nn[nH]n1 262398 4′-(5-(pyrrolidin-3-yl)-1,2,4-oxadiazol-3-yl)-2-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-3-sulfonamide::US9708336, 250 Metallo-beta-lactamase type 2 109 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262398 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262398&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823582 376224225 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496348 C[C@H](O)c1nc(no1)-c1ccc(cc1)-c1cccc(c1-c1nn[nH]n1)S(N)(=O)=O 262399 (5)-4′-(5-(1-hydroxyethyl)-1,2,4-oxadiazol-3-yl)-2(2H-tetrazol-5-yl)-[1,1′-biphenyl]-3-sulfonamide::US9708336, 251 Metallo-beta-lactamase type 2 42.5 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262399 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262399&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823583 376224226 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496351 Cc1cc(-c2nnn[nH]2)c(cc1C)S(N)(=O)=O InChI=1S/C9H11N5O2S/c1-5-3-7(9-11-13-14-12-9)8(4-6(5)2)17(10,15)16/h3-4H,1-2H3,(H2,10,15,16)(H,11,12,13,14) BILCNCVTAIGHNF-UHFFFAOYSA-N 262400 4,5-Dimethyl-2-(2H-tetrazol-5-yl)benzenesulfonamide::US9708336, 252 Metallo-beta-lactamase type 2 111500 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262400 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262400&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118257214 376224227 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496354 COc1ccc(c(c1)-c1nn[nH]n1)S(N)(=O)=O InChI=1S/C8H9N5O3S/c1-16-5-2-3-7(17(9,14)15)6(4-5)8-10-12-13-11-8/h2-4H,1H3,(H2,9,14,15)(H,10,11,12,13) MNHLBYPGGOYQGK-UHFFFAOYSA-N 262401 4-Methoxy-2-(2H-tetrazol-5-yl)benzenesulfonamide::US9708336, 253 Metallo-beta-lactamase type 2 46290 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262401 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262401&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118256843 376224228 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497332 NC[C@H]1CC[C@H](Cc2ccc(-c3ccc(N)nc3)c(-c3nnn[nH]3)c2S(N)(=O)=O)CC1 262726 6-(((1r,4r)-4- (aminomethyl)cyclohexyl)methyl)- 3-(6-aminopyridin-3-yl)-2-(1H- tetrazol-5-yl)benzenesulfonamide::US9708336, 579 Metallo-beta-lactamase type 2 17.8 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262726 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262726&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266269 376224550 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497335 NC[C@H]1CC[C@@H](Cc2ccc(-c3ccc(N)nc3)c(-c3nnn[nH]3)c2S(N)(=O)=O)CC1 262727 6-(((1s,4s)-4- (aminomethyl)cyclohexyl)methyl)- 3-(6-aminopyridin-3-yl)-2-(1H- tetrazol-5-yl)benzenesulfonamide::US9708336, 580 Metallo-beta-lactamase type 2 22.7 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262727 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262727&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266269 376224551 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497338 Nc1ccc(cn1)-c1ccc(CCC2CCNCC2)c(c1-c1nnn[nH]1)S(N)(=O)=O InChI=1S/C19H24N8O2S/c20-16-6-4-14(11-23-16)15-5-3-13(2-1-12-7-9-22-10-8-12)18(30(21,28)29)17(15)19-24-26-27-25-19/h3-6,11-12,22H,1-2,7-10H2,(H2,20,23)(H2,21,28,29)(H,24,25,26,27) ILUPLNODNOCIKM-UHFFFAOYSA-N 262728 3-(6-aminopyridin-3-yl)-6-(2- (piperidin-4-yl)ethyl)-2-(1H- tetrazol-5-yl)benzenesulfonamide::US9708336, 581 Metallo-beta-lactamase type 2 268 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262728 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262728&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266496 376224552 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497341 N[C@H]1CC[C@H](Cc2ccc(-c3ccc(cc3)C3CCNC3)c(-c3nn[nH]n3)c2S(N)(=O)=O)CC1 262729 4-(((1r,4r)-4-aminocyclohexyl)methyl)-4′-(pyrrolidin-3-yl)-2-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-3-sulfonamide::US9708336, 582 Metallo-beta-lactamase type 2 17.4 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262729 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262729&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266268 376224553 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497344 N[C@H]1CC[C@@H](Cc2ccc(-c3ccc(cc3)C3CCNC3)c(-c3nnn[nH]3)c2S(N)(=O)=O)CC1 262730 4-(((1s,4s)-4- aminocyclohexyl)methyl)-4'- (pyrrolidin-3-yl)-2-(1H- tetrazol-5-yl)-[1,1'- biphenyl]-3-sulfonamide::US9708336, 583 Metallo-beta-lactamase type 2 12.0 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262730 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262730&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266268 376224554 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497347 N[C@H]1CC[C@H](CCc2ccc(-c3ccc(cc3)C3CCNC3)c(-c3nnn[nH]3)c2S(N)(=O)=O)CC1 262731 4-(2-((1r,4s)-4- aminocyclohexyl)ethyl)-4'- (pyrrolidin-3-yl)-2-(1H- tetrazol-5-yl)-[1,1'- biphenyl]-3-sulfonamide::US9708336, 584 Metallo-beta-lactamase type 2 10.2 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262731 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262731&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266270 376224555 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497350 N[C@H]1CC[C@@H](CCc2ccc(-c3ccc(cc3)C3CCNC3)c(-c3nnn[nH]3)c2S(N)(=O)=O)CC1 262732 4-(2-((1s,4r)-4- aminocyclohexyl)ethyl)-4'- (pyrrolidin-3-yl)-2-(1H- tetrazol-5-yl)-[1,1'- biphenyl]-3-sulfonamide::US9708336, 585 Metallo-beta-lactamase type 2 17.0 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262732 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262732&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266270 376224556 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497353 NC[C@H]1CC[C@H](Cc2ccc(-c3ccc(cc3)C3CCNC3)c(-c3nnn[nH]3)c2S(N)(=O)=O)CC1 262733 4-(((1r,4r)-4- (aminomethyl)cyclohexyl) methyl)-4'-(pyrrolidin-3-yl)-2- (1H-tetrazol-5-yl)-[1,1'- biphenyl]-3-sulfonamide::US9708336, 586 Metallo-beta-lactamase type 2 7.14 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262733 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262733&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266677 376224557 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497356 NC[C@H]1CC[C@@H](Cc2ccc(-c3ccc(cc3)C3CCNC3)c(-c3nnn[nH]3)c2S(N)(=O)=O)CC1 262734 4-(((1s,4s)-4- (aminomethyl)cyclohexyl) methyl)-4'-(pyrrolidin-3-yl)-2- (1H-tetrazol-5-yl)-[1,1'- biphenyl]-3-sulfonamide::US9708336, 587 Metallo-beta-lactamase type 2 2.83 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262734 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262734&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266677 376224558 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497359 NS(=O)(=O)c1c(CC2CCNCC2)ccc(-c2ccc(cc2)C2CCNC2)c1-c1nn[nH]n1 262735 4-(piperidin-4-ylmethyl)-4'- (pyrrolidin-3-yl)-2-(2H- tetrazol-5-yl)-[1,1'- biphenyl]-3-sulfonamide::US9708336, 588 Metallo-beta-lactamase type 2 28.8 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262735 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262735&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266257 376224559 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497362 NC[C@H]1CCC(CC1)c1ccc(CC2CCNCC2)c(c1-c1nn[nH]n1)S(N)(=O)=O 262736 3-((1r,4r)-4-(aminomethyl)cyclohexyl)-6-(piperidin-4-ylmethyl)-2-(2H-tetrazol-5-yl)benzenesulfonamide::US9708336, 589 Metallo-beta-lactamase type 2 146 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262736 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262736&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266380 376224560 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497365 NC[C@H]1CC[C@H](CC1)c1ccc(CC2CCNCC2)c(c1-c1nn[nH]n1)S(N)(=O)=O 262737 US9708336, 590 Metallo-beta-lactamase type 2 24.5 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262737 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262737&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266380 376224561 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497368 NC[C@H]1CC[C@@H](CC1)c1ccc(CCC2CCNCC2)c(c1-c1nnn[nH]1)S(N)(=O)=O 262738 3-((1r,4r)-4- (aminomethyl)cyclohexyl)-6-(2- (piperidin-4-yl)ethyl)-2-(1H- tetrazol-5-yl) benzenesulfonamide::US9708336, 591 Metallo-beta-lactamase type 2 320 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262738 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262738&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823672 376224562 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497371 NC[C@H]1CC[C@H](CC1)c1ccc(CCC2CCNCC2)c(c1-c1nnn[nH]1)S(N)(=O)=O 262739 3-((1s,4s)-4- (aminomethyl)cyclohexyl)-6-(2- (piperidin-4-yl)ethyl)-2-(1H- tetrazol-5- yl)benzenesulfonamide::US9708336, 592 Metallo-beta-lactamase type 2 84.1 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262739 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262739&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823672 376224563 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497374 NCc1ccc(cc1)-c1ccc(CC2CCNCC2)c(c1-c1nn[nH]n1)S(N)(=O)=O InChI=1S/C20H25N7O2S/c21-12-14-1-3-15(4-2-14)17-6-5-16(11-13-7-9-23-10-8-13)19(30(22,28)29)18(17)20-24-26-27-25-20/h1-6,13,23H,7-12,21H2,(H2,22,28,29)(H,24,25,26,27) YFQPFIUZCDXZDN-UHFFFAOYSA-N 262740 4′-(aminomethyl)-4-(piperidin-4-ylmethyl)-2-(2H-tetrazol-5-yl)biphenyl-3-sulfonamide::US9708336, 593 Metallo-beta-lactamase type 2 273 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262740 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262740&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118257017 376224564 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497377 NC(=N)NCc1ccc(cc1)-c1ccc(CC2CCNCC2)c(c1-c1nn[nH]n1)S(N)(=O)=O InChI=1S/C21H27N9O2S/c22-21(23)26-12-14-1-3-15(4-2-14)17-6-5-16(11-13-7-9-25-10-8-13)19(33(24,31)32)18(17)20-27-29-30-28-20/h1-6,13,25H,7-12H2,(H4,22,23,26)(H2,24,31,32)(H,27,28,29,30) NDHQIAIHWUYGHW-UHFFFAOYSA-N 262741 4′-(guanidinomethyl)-4-(piperidin-4-ylmethyl)-2-(2H-tetrazol-5-yl)biphenyl-3-sulfonamide::US9708336, 594 Metallo-beta-lactamase type 2 51.7 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262741 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262741&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118256926 376224565 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497380 N[C@H]1CC[C@H](Cc2ccc(-c3ccc(cc3)C3CNC3)c(-c3nn[nH]n3)c2S(N)(=O)=O)CC1 262742 4-(((1r,4r)-4-aminocyclohexyl)methyl)-4′-(azetidin-3-yl)-2-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-3-sulfonamide::US9708336, 595 Metallo-beta-lactamase type 2 42.6 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262742 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262742&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118257205 376224566 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497383 N[C@H]1CC[C@@H](Cc2ccc(-c3ccc(cc3)C3CNC3)c(-c3nnn[nH]3)c2S(N)(=O)=O)CC1 262743 4-(((1s,4s)-4- aminocyclohexyl)methyl)-4'- (azetidin-3-yl)-2-(1H-tetrazol- 5-yl)-[1,1'-biphenyl]-3- sulfonamide::US9708336, 596 Metallo-beta-lactamase type 2 10.6 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262743 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262743&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823673 376224567 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497386 NS(=O)(=O)c1c(CC2CCNCC2)ccc(-c2ccc(cc2)C2CNC2)c1-c1nnn[nH]1 InChI=1S/C22H27N7O2S/c23-32(30,31)21-17(11-14-7-9-24-10-8-14)5-6-19(20(21)22-26-28-29-27-22)16-3-1-15(2-4-16)18-12-25-13-18/h1-6,14,18,24-25H,7-13H2,(H2,23,30,31)(H,26,27,28,29) JFZGUHFODHFIIN-UHFFFAOYSA-N 262744 3-[4-(azetidin-3-yl)phenyl]-6- (4-piperidylmethyl)-2-(1H- tetrazol-5- yl)benzenesulfonamide::US9708336, 597 Metallo-beta-lactamase type 2 46.0 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262744 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262744&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823674 376224568 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497389 NS(=O)(=O)c1c(CCC2CCNCC2)ccc(-c2ccc(cc2)C2CNC2)c1-c1nnn[nH]1 InChI=1S/C23H29N7O2S/c24-33(31,32)22-18(2-1-15-9-11-25-12-10-15)7-8-20(21(22)23-27-29-30-28-23)17-5-3-16(4-6-17)19-13-26-14-19/h3-8,15,19,25-26H,1-2,9-14H2,(H2,24,31,32)(H,27,28,29,30) VSOKKJLYGJIKMK-UHFFFAOYSA-N 262745 3-[4-(azetidin-3-yl)phenyl]-6- [2-(4-piperidyl)ethyl]-2-(1H- tetrazol-5- yl)benzenesulfonamide::US9708336, 598 Metallo-beta-lactamase type 2 135 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262745 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262745&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823675 376224569 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497392 N[C@H]1CC[C@H](CCc2ccc(-c3ccc(cc3)C3CNC3)c(-c3nnn[nH]3)c2S(N)(=O)=O)CC1 262746 4-(2-((1r,4s)-4- aminocyclohexyl)ethyl)-4'- (azetidin-3-yl)-2-(1H-tetrazol- 5-yl)-[1,1'-biphenyl]-3- sulfonamide::US9708336, 599 Metallo-beta-lactamase type 2 6.43 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262746 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262746&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823676 376224570 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497395 N[C@H]1CC[C@@H](CCc2ccc(-c3ccc(cc3)C3CNC3)c(-c3nnn[nH]3)c2S(N)(=O)=O)CC1 262747 4-(2-((1s,4r)-4- aminocyclohexyl)ethyl)-4'- (azetidin-3-yl)-2-(1H-tetrazol- 5-yl)-[1,1'-biphenyl]-3- sulfonamide::US9708336, 600 Metallo-beta-lactamase type 2 43.8 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262747 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262747&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823676 376224571 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497854 Nc1nccc(n1)-c1cccc(c1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)C(F)(F)F InChI=1S/C18H13F3N8O2S/c19-18(20,21)12-5-4-11(14(15(12)32(23,30)31)16-26-28-29-27-16)9-2-1-3-10(8-9)13-6-7-24-17(22)25-13/h1-8H,(H2,22,24,25)(H2,23,30,31)(H,26,27,28,29) LMSLADPOSVJLII-UHFFFAOYSA-N 262900 3'-(2-aminopyrimidin-4-yl)-2- (1H-tetrazol-5-yl)-4- (trifluoromethyl)biphenyl-3- sulfonamdie::US9708336, 753 Metallo-beta-lactamase type 2 2.02 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262900 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262900&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823726 376224720 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497857 N[C@@H]1CN(CC11CC1)c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)C(F)(F)F 262901 3-[(7S)-7-amino-5- azaspiro[2.4]hept-5-yl]-2-(1H- tetrazol-5-yl)-6- (trifluoromethyl) benzenesulfonamide::US9708336, 754 Metallo-beta-lactamase type 2 869 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262901 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262901&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823727 376224721 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497860 NCCC1CCN(CC1)c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)C(F)(F)F InChI=1S/C15H20F3N7O2S/c16-15(17,18)10-1-2-11(25-7-4-9(3-6-19)5-8-25)12(13(10)28(20,26)27)14-21-23-24-22-14/h1-2,9H,3-8,19H2,(H2,20,26,27)(H,21,22,23,24) AEWAFQUWLSPMJJ-UHFFFAOYSA-N 262902 3-[4-(2-aminoethyl)piperidin-1- yl]-2-(1H-tetrazol-5-yl)-6- (trifluoromethyl) benzenesulfonamide::US9708336, 755 Metallo-beta-lactamase type 2 22.1 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262902 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262902&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823728 376224722 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496357 NS(=O)(=O)c1ccc(O)cc1-c1nn[nH]n1 InChI=1S/C7H7N5O3S/c8-16(14,15)6-2-1-4(13)3-5(6)7-9-11-12-10-7/h1-3,13H,(H2,8,14,15)(H,9,10,11,12) ZXZXCSKWBFNITA-UHFFFAOYSA-N 262402 4-Hydroxy-2-(2H-tetrazol-yl)benzenesulfonamide::US9708336, 254 Metallo-beta-lactamase type 2 20000 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262402 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262402&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118256871 376224229 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496360 COC(=O)c1ccc(-c2nn[nH]n2)c(c1)S(N)(=O)=O InChI=1S/C9H9N5O4S/c1-18-9(15)5-2-3-6(8-11-13-14-12-8)7(4-5)19(10,16)17/h2-4H,1H3,(H2,10,16,17)(H,11,12,13,14) IKHWRVYGFJFJJY-UHFFFAOYSA-N 262403 Methyl 3-sulfamoyl-4-(2H-tetrazol-5-yl)benzoate::US9708336, 255 Metallo-beta-lactamase type 2 20000 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262403 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262403&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118257114 376224230 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496363 NS(=O)(=O)c1cccc(c1-c1nnn[nH]1)C(F)(F)F InChI=1S/C8H6F3N5O2S/c9-8(10,11)4-2-1-3-5(19(12,17)18)6(4)7-13-15-16-14-7/h1-3H,(H2,12,17,18)(H,13,14,15,16) PPODPZHITFTQFN-UHFFFAOYSA-N 262404 2-(1H-Tetrazol-5-yl)-3-(trifluoromethyl)benzenesulfonamide::US9708336, 256 Metallo-beta-lactamase type 2 6260 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262404 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262404&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118257553 376224231 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496366 COc1cccc(c1-c1nnn[nH]1)S(N)(=O)=O InChI=1S/C8H9N5O3S/c1-16-5-3-2-4-6(17(9,14)15)7(5)8-10-12-13-11-8/h2-4H,1H3,(H2,9,14,15)(H,10,11,12,13) FBUPPPMYCHPGCK-UHFFFAOYSA-N 262405 3-Methoxy-2-(1H-tetrazol-5-yl)benzenesulfonamide::US9708336, 257 Metallo-beta-lactamase type 2 8277 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262405 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262405&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118257246 376224232 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496369 NS(=O)(=O)c1cccc(-c2ccc(CO)nc2)c1-c1nnn[nH]1 InChI=1S/C13H12N6O3S/c14-23(21,22)11-3-1-2-10(12(11)13-16-18-19-17-13)8-4-5-9(7-20)15-6-8/h1-6,20H,7H2,(H2,14,21,22)(H,16,17,18,19) HBXLIZYOJWSEST-UHFFFAOYSA-N 262406 3-(6-(Hydroxymethyl)pyridin-3-yl)-2-(1H-tetrazol-5-yl)benzenesulfonamide::US9708336, 258 Metallo-beta-lactamase type 2 888 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262406 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262406&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823584 376224233 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496372 NS(=O)(=O)c1c(Br)ccc(-c2ccc(cc2)C2CCNCC2)c1-c1nnn[nH]1 InChI=1S/C18H19BrN6O2S/c19-15-6-5-14(16(17(15)28(20,26)27)18-22-24-25-23-18)13-3-1-11(2-4-13)12-7-9-21-10-8-12/h1-6,12,21H,7-10H2,(H2,20,26,27)(H,22,23,24,25) KIHQLFRLBARMNB-UHFFFAOYSA-N 262407 4-Bromo-4′-(piperidin-4-yl)-2-(1H-tetrazol-5-yl)-[1,1′-biphenyl]-3-sulfonamide::US9708336, 259 Metallo-beta-lactamase type 2 10.1 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262407 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262407&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118257155 376224234 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496375 CCCc1ccc(-c2ccc(cc2)C2CCNCC2)c(-c2nnn[nH]2)c1S(N)(=O)=O InChI=1S/C21H26N6O2S/c1-2-3-17-8-9-18(19(20(17)30(22,28)29)21-24-26-27-25-21)16-6-4-14(5-7-16)15-10-12-23-13-11-15/h4-9,15,23H,2-3,10-13H2,1H3,(H2,22,28,29)(H,24,25,26,27) FHNBONDECPZXAH-UHFFFAOYSA-N 262408 4′-(Piperidin-4-yl)-4-propyl-2-(1H-tetrazol-5-yl)-[1,1′-biphenyl]-3-sulfonamide::US9708336, 260 Metallo-beta-lactamase type 2 6.72 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262408 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262408&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118256971 376224235 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496378 NS(=O)(=O)c1c(Cc2ccccc2)ccc(-c2ccc(cc2)C2CCNCC2)c1-c1nnn[nH]1 InChI=1S/C25H26N6O2S/c26-34(32,33)24-21(16-17-4-2-1-3-5-17)10-11-22(23(24)25-28-30-31-29-25)20-8-6-18(7-9-20)19-12-14-27-15-13-19/h1-11,19,27H,12-16H2,(H2,26,32,33)(H,28,29,30,31) NGUNSOGTORAKMI-UHFFFAOYSA-N 262409 4-benzyl-4'-(piperidin-4-yl)-2- (1H-tetrazol-5-yl)-[1,1'- biphenyl]-3-sulfonamide, 2,2,2-trifluoroacetate salt::US9708336, 261 Metallo-beta-lactamase type 2 1.72 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262409 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262409&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266424 376224236 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496381 Cc1ccc(-c2ccc(cc2)C2CCNCC2)c(-c2nnn[nH]2)c1S(N)(=O)=O InChI=1S/C19H22N6O2S/c1-12-2-7-16(17(18(12)28(20,26)27)19-22-24-25-23-19)15-5-3-13(4-6-15)14-8-10-21-11-9-14/h2-7,14,21H,8-11H2,1H3,(H2,20,26,27)(H,22,23,24,25) BNJSDDQTTZLYAC-UHFFFAOYSA-N 262410 4-methyl-4'-(piperidin-4-yl)-2- (1H-tetrazol-5-yl)-[1,1'- biphenyl]-3-sulfonamide, 2,2,2-trifluoroacetate salt::US9708336, 262 Metallo-beta-lactamase type 2 72.4 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262410 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262410&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266633 376224237 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496384 Cc1ccc(cc1)-c1ccc(Cl)c(c1-c1nn[nH]n1)S(N)(=O)=O InChI=1S/C14H12ClN5O2S/c1-8-2-4-9(5-3-8)10-6-7-11(15)13(23(16,21)22)12(10)14-17-19-20-18-14/h2-7H,1H3,(H2,16,21,22)(H,17,18,19,20) HBKLITOBRWBYOR-UHFFFAOYSA-N 262411 4-chloro-4′-methyl-2-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-3-sulfonamide::US9708336, 263 Metallo-beta-lactamase type 2 21.0 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262411 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262411&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823585 376224238 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496387 Nc1ccc(cn1)-c1ccc(Br)c(c1-c1nn[nH]n1)S(N)(=O)=O InChI=1S/C12H10BrN7O2S/c13-8-3-2-7(6-1-4-9(14)16-5-6)10(11(8)23(15,21)22)12-17-19-20-18-12/h1-5H,(H2,14,16)(H2,15,21,22)(H,17,18,19,20) UOHDSLMFNYEDNF-UHFFFAOYSA-N 262412 3-(6-aminopyridin-3-yl)-6-bromo-2-(2H-tetrazol-5-yl)benzenesulfonamide::US9708336, 264 Metallo-beta-lactamase type 2 16.9 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262412 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262412&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823586 376224239 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496390 Nc1ccc(cn1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)C(F)(F)F InChI=1S/C13H10F3N7O2S/c14-13(15,16)8-3-2-7(6-1-4-9(17)19-5-6)10(11(8)26(18,24)25)12-20-22-23-21-12/h1-5H,(H2,17,19)(H2,18,24,25)(H,20,21,22,23) ZHRHIMOCSSNYTE-UHFFFAOYSA-N 262413 3-(6-aminopyridin-3-yl)-2-(2H-tetrazol-5-yl)-6-(trifluoromethyl)benzenesulfonamide::US9708336, 265 Metallo-beta-lactamase type 2 6.93 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262413 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262413&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823587 376224240 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496393 NS(=O)(=O)c1c(Br)ccc(-c2ccnc3ccccc23)c1-c1nn[nH]n1 InChI=1S/C16H11BrN6O2S/c17-12-6-5-11(9-7-8-19-13-4-2-1-3-10(9)13)14(15(12)26(18,24)25)16-20-22-23-21-16/h1-8H,(H2,18,24,25)(H,20,21,22,23) QQDKPMAJBIQNTJ-UHFFFAOYSA-N 262414 US9708336, 266 Metallo-beta-lactamase type 2 12.6 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262414 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262414&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266425 376224241 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496396 Cc1ccc(cc1)-c1ccc(Br)c(c1-c1nn[nH]n1)S(N)(=O)=O InChI=1S/C14H12BrN5O2S/c1-8-2-4-9(5-3-8)10-6-7-11(15)13(23(16,21)22)12(10)14-17-19-20-18-14/h2-7H,1H3,(H2,16,21,22)(H,17,18,19,20) FXMGXKLSCOYXLL-UHFFFAOYSA-N 262415 US9708336, 267 Metallo-beta-lactamase type 2 2.00 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262415 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262415&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266420 376224242 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496399 Cc1ccc(cc1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)C(F)(F)F InChI=1S/C15H12F3N5O2S/c1-8-2-4-9(5-3-8)10-6-7-11(15(16,17)18)13(26(19,24)25)12(10)14-20-22-23-21-14/h2-7H,1H3,(H2,19,24,25)(H,20,21,22,23) MDJCJBNFQJOJKL-UHFFFAOYSA-N 262416 US9708336, 268 Metallo-beta-lactamase type 2 1.64 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262416 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262416&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266423 376224243 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496402 NS(=O)(=O)c1c(ccc(-c2ccc(cc2)C2CCNCC2)c1-c1nn[nH]n1)C(F)(F)F InChI=1S/C19H19F3N6O2S/c20-19(21,22)15-6-5-14(16(17(15)31(23,29)30)18-25-27-28-26-18)13-3-1-11(2-4-13)12-7-9-24-10-8-12/h1-6,12,24H,7-10H2,(H2,23,29,30)(H,25,26,27,28) IVCVEUVKOPZGEI-UHFFFAOYSA-N 262417 US9708336, 269 Metallo-beta-lactamase type 2 1.43 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262417 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262417&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266421 376224244 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496405 CS(=O)(=O)Nc1ccc(cc1)-c1ccc(Br)c(c1-c1nn[nH]n1)S(N)(=O)=O InChI=1S/C14H13BrN6O4S2/c1-26(22,23)19-9-4-2-8(3-5-9)10-6-7-11(15)13(27(16,24)25)12(10)14-17-20-21-18-14/h2-7,19H,1H3,(H2,16,24,25)(H,17,18,20,21) PJVYAGSGHYELEE-UHFFFAOYSA-N 262418 US9708336, 270 Metallo-beta-lactamase type 2 4.86 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262418 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262418&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266422 376224245 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496408 NCc1ccc(cc1)-c1ccc(Br)c(c1-c1nn[nH]n1)S(N)(=O)=O InChI=1S/C14H13BrN6O2S/c15-11-6-5-10(9-3-1-8(7-16)2-4-9)12(13(11)24(17,22)23)14-18-20-21-19-14/h1-6H,7,16H2,(H2,17,22,23)(H,18,19,20,21) ISSJBDDNKNJGHE-UHFFFAOYSA-N 262419 US9708336, 271 Metallo-beta-lactamase type 2 23.4 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262419 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262419&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266466 376224246 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496411 NS(=O)(=O)c1c(Br)ccc(-c2ccc3CNCc3c2)c1-c1nn[nH]n1 InChI=1S/C15H13BrN6O2S/c16-12-4-3-11(8-1-2-9-6-18-7-10(9)5-8)13(14(12)25(17,23)24)15-19-21-22-20-15/h1-5,18H,6-7H2,(H2,17,23,24)(H,19,20,21,22) BTXPAPFWNZJFSN-UHFFFAOYSA-N 262420 US9708336, 272 Metallo-beta-lactamase type 2 49.0 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262420 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262420&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266438 376224247 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496414 NS(=O)(=O)c1c(ccc(-c2ccnc3ccccc23)c1-c1nn[nH]n1)C(F)(F)F InChI=1S/C17H11F3N6O2S/c18-17(19,20)12-6-5-11(9-7-8-22-13-4-2-1-3-10(9)13)14(15(12)29(21,27)28)16-23-25-26-24-16/h1-8H,(H2,21,27,28)(H,23,24,25,26) ZASMARAVUHXMNX-UHFFFAOYSA-N 262421 US9708336, 273 Metallo-beta-lactamase type 2 3.21 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262421 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262421&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118265930 376224248 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496417 CS(=O)(=O)Nc1ccc(cc1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)C(F)(F)F InChI=1S/C15H13F3N6O4S2/c1-29(25,26)22-9-4-2-8(3-5-9)10-6-7-11(15(16,17)18)13(30(19,27)28)12(10)14-20-23-24-21-14/h2-7,22H,1H3,(H2,19,27,28)(H,20,21,23,24) CMMBLDYSYHNMCK-UHFFFAOYSA-N 262422 US9708336, 274 Metallo-beta-lactamase type 2 0.637 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262422 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262422&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118265924 376224249 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496420 NS(=O)(=O)c1c(ccc(-c2ccnc3ccccc23)c1-c1nn[nH]n1)C1CC1 InChI=1S/C19H16N6O2S/c20-28(26,27)18-12(11-5-6-11)7-8-15(17(18)19-22-24-25-23-19)13-9-10-21-16-4-2-1-3-14(13)16/h1-4,7-11H,5-6H2,(H2,20,26,27)(H,22,23,24,25) IRVYFDMFPUWLGE-UHFFFAOYSA-N 262423 6-cyclopropyl-3-(quinolin-4-yl)-2-(2H-tetrazol-5-yl)benzenesulfonamide::US9708336, 275 Metallo-beta-lactamase type 2 6.70 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262423 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262423&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823588 376224250 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497863 NS(=O)(=O)c1c(ccc(N2C[C@@H](O)[C@H](O)C2)c1-c1nnn[nH]1)C(F)(F)F 262903 3-[(3R,4R)-3,4- dihydroxypyrrolidin-1-yl]-2-(1H- tetrazol-5-yl)-6- (trifluoromethyl) benzenesulfonamide::US9708336, 756 Metallo-beta-lactamase type 2 89.1 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262903 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262903&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823729 376224723 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497866 NS(=O)(=O)c1c(ccc(N2C[C@H](O)[C@H](O)C2)c1-c1nnn[nH]1)C(F)(F)F 262904 3-[(3R,4S)-3,4- dihydroxypyrrolidin-1-yl]-2-(1H- tetrazol-5-yl)-6- (trifluoromethyl) benzenesulfonamide::US9708336, 757 Metallo-beta-lactamase type 2 111 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262904 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262904&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823730 376224724 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497869 NC1CN(C1)C1CCN(CC1)c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)C(F)(F)F InChI=1S/C16H21F3N8O2S/c17-16(18,19)11-1-2-12(13(14(11)30(21,28)29)15-22-24-25-23-15)26-5-3-10(4-6-26)27-7-9(20)8-27/h1-2,9-10H,3-8,20H2,(H2,21,28,29)(H,22,23,24,25) DRTPPXJSUXEEFF-UHFFFAOYSA-N 262905 3-[4-(3-aminoazetidin-1- yl)piperidin-1-yl]-2-(1H- tetrazol-5-yl)-6- (trifluoromethyl) benzenesulfonamide::US9708336, 758 Metallo-beta-lactamase type 2 45.8 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262905 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262905&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823731 376224725 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497872 NS(=O)(=O)c1c(ccc(N2CCN(CCO)CC2)c1-c1nnn[nH]1)C(F)(F)F InChI=1S/C14H18F3N7O3S/c15-14(16,17)9-1-2-10(24-5-3-23(4-6-24)7-8-25)11(12(9)28(18,26)27)13-19-21-22-20-13/h1-2,25H,3-8H2,(H2,18,26,27)(H,19,20,21,22) ZHWYSEUVAXEVII-UHFFFAOYSA-N 262906 3-[4-(2-hydroxyethyl)piperazin- 1-yl]-2-(1H-tetrazol-5-yl)-6- (trifluoromethyl) benzenesulfonamide::US9708336, 759 Metallo-beta-lactamase type 2 40.9 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262906 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262906&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823732 376224726 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497875 CC(C)(C)C(=O)NCC1CCN(CC1)c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)C(F)(F)F InChI=1S/C19H26F3N7O3S/c1-18(2,3)17(30)24-10-11-6-8-29(9-7-11)13-5-4-12(19(20,21)22)15(33(23,31)32)14(13)16-25-27-28-26-16/h4-5,11H,6-10H2,1-3H3,(H,24,30)(H2,23,31,32)(H,25,26,27,28) XMTWBTZFNXRDOK-UHFFFAOYSA-N 262907 2,2-dimethyl-N-({1-[3- sulfamoyl-2-(1H-tetrazol-5-yl)- 4- (trifluoromethyl)phenyl] piperidin-4-yl}methyl) propanamide::US9708336, 760 Metallo-beta-lactamase type 2 2.08 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262907 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262907&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823733 376224727 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497878 NC1CCCC11CCN(CC1)c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)C(F)(F)F 262908 3-(1-amino-8-azaspiro[4.5]dec- 8-yl)-2-(1H-tetrazol-5-yl)-6- (trifluoromethyl) benzenesulfonamide::US9708336, 761 Metallo-beta-lactamase type 2 104 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262908 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262908&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823734 376224728 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497881 NCC1CN(C1)C1CCN(CC1)c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)C(F)(F)F InChI=1S/C17H23F3N8O2S/c18-17(19,20)12-1-2-13(14(15(12)31(22,29)30)16-23-25-26-24-16)27-5-3-11(4-6-27)28-8-10(7-21)9-28/h1-2,10-11H,3-9,21H2,(H2,22,29,30)(H,23,24,25,26) NFFIFLHCBXTWAV-UHFFFAOYSA-N 262909 3-{4-[3-(aminomethyl)azetidin- 1-yl]piperidin-1-yl}-2-(1H- tetrazol-5-yl)-6- (trifluoromethyl) benzenesulfonamide::US9708336, 762 Metallo-beta-lactamase type 2 123 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262909 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262909&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823735 376224729 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497884 NS(=O)(=O)c1c(ccc(N2CCN(CCCO)CC2)c1-c1nnn[nH]1)C(F)(F)F InChI=1S/C15H20F3N7O3S/c16-15(17,18)10-2-3-11(25-7-5-24(6-8-25)4-1-9-26)12(13(10)29(19,27)28)14-20-22-23-21-14/h2-3,26H,1,4-9H2,(H2,19,27,28)(H,20,21,22,23) XVYDFDFRXDWKLC-UHFFFAOYSA-N 262811 3-[4-(3-hydroxypropyl)piperazin-1- yl]-2-(1H-tetrazol-5-yl)-6- (trifluoromethyl)benzenesulfonamide::US9708336, 664::US9708336, 763 Metallo-beta-lactamase type 2 46.4 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262811 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262811&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266047 376224635 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497887 Nc1nnc(s1)C1CCN(CC1)c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)C(F)(F)F InChI=1S/C15H16F3N9O2S2/c16-15(17,18)8-1-2-9(10(11(8)31(20,28)29)12-21-25-26-22-12)27-5-3-7(4-6-27)13-23-24-14(19)30-13/h1-2,7H,3-6H2,(H2,19,24)(H2,20,28,29)(H,21,22,25,26) LADMFKHYTMMWKU-UHFFFAOYSA-N 262911 3-[4-(5-amino-1,3,4-thiadiazol- 2-yl)piperidin-1-yl]-2-(1H- tetrazol-5-yl)-6- (trifluoromethyl) benzenesulfonamide::US9708336, 764 Metallo-beta-lactamase type 2 68.7 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262911 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262911&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823736 376224730 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497890 NCCCCN1CCN(CC1)c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)C(F)(F)F InChI=1S/C16H23F3N8O2S/c17-16(18,19)11-3-4-12(27-9-7-26(8-10-27)6-2-1-5-20)13(14(11)30(21,28)29)15-22-24-25-23-15/h3-4H,1-2,5-10,20H2,(H2,21,28,29)(H,22,23,24,25) UUFLCGUMGFZSKP-UHFFFAOYSA-N 262912 3-[4-(4-aminobutyl)piperazin-1- yl]-2-(1H-tetrazol-5-yl)-6- (trifluoromethyl) benzenesulfonamide::US9708336, 765 Metallo-beta-lactamase type 2 131 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262912 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262912&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823737 376224731 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497893 NC1(CC1)C1CCN(C1)c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)C(F)(F)F 262913 3-[3-(1- aminocyclopropyl)pyrrolidin-1- yl]-2-(1H-tetrazol-5-yl)-6- (trifluoromethyl) benzenesulfonamide::US9708336, 766 Metallo-beta-lactamase type 2 120 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262913 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262913&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823738 376224732 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497896 NC1CCC2CN(CC2C1)c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)C(F)(F)F 262914 3-(5-aminooctahydro-2H- isoindol-2-yl)-2-(1H-tetrazol-5- yl)-6- (trifluoromethyl) benzenesulfonamide::US9708336, 767 Metallo-beta-lactamase type 2 223 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262914 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262914&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823739 376224733 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497899 NC1CCN(C1)C1CCN(CC1)c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)C(F)(F)F 262915 3-[4-(3-aminopyrrolidin-1- yl)piperidin-1-yl]-2-(1H- tetrazol-5-yl)-6- (trifluoromethyl) benzenesulfonamide::US9708336, 768 Metallo-beta-lactamase type 2 36.7 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262915 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262915&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823740 376224734 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497902 NS(=O)(=O)c1c(ccc(N2CCCC(CCCO)C2)c1-c1nnn[nH]1)C(F)(F)F 262916 3-[3-(3- hydroxypropyl)piperidin-1-yl]- 2-(1H-tetrazol-5-yl)-6- (trifluoromethyl) benzenesulfonamide::US9708336, 769 Metallo-beta-lactamase type 2 11.4 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262916 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262916&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823741 376224735 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497905 NS(=O)(=O)c1c(ccc(N2CCC(C2)N2CCNCC2)c1-c1nnn[nH]1)C(F)(F)F 262917 3-(3-piperazin-1-ylpyrrolidin-1- yl)-2-(1H-tetrazol-5-yl)-6- (trifluoromethyl) benzenesulfonamide::US9708336, 770 Metallo-beta-lactamase type 2 251 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262917 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262917&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823742 376224736 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497908 NS(=O)(=O)c1c(ccc(N2CCC3(C2)CCNCC3)c1-c1nnn[nH]1)C(F)(F)F InChI=1S/C16H20F3N7O2S/c17-16(18,19)10-1-2-11(26-8-5-15(9-26)3-6-21-7-4-15)12(13(10)29(20,27)28)14-22-24-25-23-14/h1-2,21H,3-9H2,(H2,20,27,28)(H,22,23,24,25) IQPNSNHBNISWSS-UHFFFAOYSA-N 262918 3-(2,8-diazaspiro[4.5]dec-2-yl)- 2-(1H-tetrazol-5-yl)-6- (trifluoromethyl) benzenesulfonamide::US9708336, 771 Metallo-beta-lactamase type 2 227 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262918 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262918&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823743 376224737 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497911 NS(=O)(=O)c1c(ccc(N2CCCC3(CCNCC3)C2)c1-c1nnn[nH]1)C(F)(F)F InChI=1S/C17H22F3N7O2S/c18-17(19,20)11-2-3-12(13(14(11)30(21,28)29)15-23-25-26-24-15)27-9-1-4-16(10-27)5-7-22-8-6-16/h2-3,22H,1,4-10H2,(H2,21,28,29)(H,23,24,25,26) GPZUDMSOAFCEAD-UHFFFAOYSA-N 262919 3-(2,9-diazaspiro[5.5]undec-2- yl)-2-(1H-tetrazol-5-yl)-6- (trifluoromethyl) benzenesulfonamide::US9708336, 772 Metallo-beta-lactamase type 2 114 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262919 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262919&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823744 376224738 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497914 NS(=O)(=O)c1c(ccc(N2CC[C@H]3NCCO[C@@H]3C2)c1-c1nnn[nH]1)C(F)(F)F 262920 3-[(4aR,8aR)-octahydro-6H- pyrido[3,4-b][1,4]oxazin-6-yl]- 2-(1H-tetrazol-5-yl)-6- (trifluoromethyl) benzenesulfonamide::US9708336, 773 Metallo-beta-lactamase type 2 17.2 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262920 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262920&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823745 376224739 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497917 NS(=O)(=O)c1c(ccc(N2CCC(C2)C2CCNCC2)c1-c1nnn[nH]1)C(F)(F)F 262921 3-(3-piperidin-4-ylpyrrolidin-1- yl)-2-(1H-tetrazol-5-yl)-6- (trifluoromethyl) benzenesulfonamide::US9708336, 774 Metallo-beta-lactamase type 2 29.1 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262921 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262921&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823746 376224740 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497920 NS(=O)(=O)c1c(ccc(N2CCC3(CCNC3)CC2)c1-c1nnn[nH]1)C(F)(F)F InChI=1S/C16H20F3N7O2S/c17-16(18,19)10-1-2-11(26-7-4-15(5-8-26)3-6-21-9-15)12(13(10)29(20,27)28)14-22-24-25-23-14/h1-2,21H,3-9H2,(H2,20,27,28)(H,22,23,24,25) SXWDQAITIQPULT-UHFFFAOYSA-N 262922 3-(2,8-diazaspiro[4.5]dec-8-yl)- 2-(1H-tetrazol-5-yl)-6- (trifluoromethyl) benzenesulfonamide::US9708336, 775 Metallo-beta-lactamase type 2 35.8 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262922 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262922&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823747 376224741 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497923 NS(=O)(=O)c1c(ccc(N2CCC3(CCCNC3)CC2)c1-c1nnn[nH]1)C(F)(F)F InChI=1S/C17H22F3N7O2S/c18-17(19,20)11-2-3-12(13(14(11)30(21,28)29)15-23-25-26-24-15)27-8-5-16(6-9-27)4-1-7-22-10-16/h2-3,22H,1,4-10H2,(H2,21,28,29)(H,23,24,25,26) STGIVWRLJILMJD-UHFFFAOYSA-N 262923 3-(2,9-diazaspiro[5.5]undec-9- yl)-2-(1H-tetrazol-5-yl)-6- (trifluoromethyl) benzenesulfonamide::US9708336, 776 Metallo-beta-lactamase type 2 55.9 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262923 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262923&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823748 376224742 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497926 NS(=O)(=O)c1c(ccc(NC2(CC2)C2CCNC2)c1-c1nnn[nH]1)C(F)(F)F 262924 3-[(1-pyrrolidin-3- ylcyclopropyl)amino]-2-(1H- tetrazol-5-yl)-6- (trifluoromethyl) benzenesulfonamide::US9708336, 777 Metallo-beta-lactamase type 2 51.3 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262924 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262924&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823749 376224743 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496423 NS(=O)(=O)c1c(Cl)ccc(-c2ccc(cc2)C2CCNCC2)c1-c1nn[nH]n1 InChI=1S/C18H19ClN6O2S/c19-15-6-5-14(16(17(15)28(20,26)27)18-22-24-25-23-18)13-3-1-11(2-4-13)12-7-9-21-10-8-12/h1-6,12,21H,7-10H2,(H2,20,26,27)(H,22,23,24,25) SUVLIORBKJRBES-UHFFFAOYSA-N 262424 4-chloro-4′-(piperidin-4-yl)-2-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-3-sulfonamide::US9708336, 276 Metallo-beta-lactamase type 2 8.75 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262424 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262424&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823589 376224251 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496426 NS(=O)(=O)c1nncc(-c2ccc(Br)cc2)c1-c1nn[nH]n1 InChI=1S/C11H8BrN7O2S/c12-7-3-1-6(2-4-7)8-5-14-17-11(22(13,20)21)9(8)10-15-18-19-16-10/h1-5H,(H2,13,20,21)(H,15,16,18,19) GZANEEQKFCHOMI-UHFFFAOYSA-N 262425 5-(4-Bromophenyl)-4-(2H-tetrazol-5-yl)pyridazine-3-sulfonamide::US9708336, 277 Metallo-beta-lactamase type 2 5270 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262425 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262425&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823590 376224252 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496429 CS(=O)(=O)c1nc2cc(Cl)c(cc2[nH]1)-c1cccc(c1-c1nn[nH]n1)S(N)(=O)=O InChI=1S/C15H12ClN7O4S2/c1-28(24,25)15-18-10-5-8(9(16)6-11(10)19-15)7-3-2-4-12(29(17,26)27)13(7)14-20-22-23-21-14/h2-6H,1H3,(H,18,19)(H2,17,26,27)(H,20,21,22,23) REZWFXOZWCRYNQ-UHFFFAOYSA-N 262426 3-(5-chloro-2-(methylsulfonyl)-1H-benzo[d]imidazol-6-yl)-2-(2H-tetrazol-5-yl)benzenesulfonamide::US9708336, 278 Metallo-beta-lactamase type 2 536 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262426 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262426&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118256882 376224253 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496432 COc1nc2cc(Cl)c(cc2[nH]1)-c1cccc(c1-c1nn[nH]n1)S(N)(=O)=O InChI=1S/C15H12ClN7O3S/c1-26-15-18-10-5-8(9(16)6-11(10)19-15)7-3-2-4-12(27(17,24)25)13(7)14-20-22-23-21-14/h2-6H,1H3,(H,18,19)(H2,17,24,25)(H,20,21,22,23) ZRYHKWXELLECPN-UHFFFAOYSA-N 262427 3-(5-chloro-2-methoxy-1H-benzo[d]imidazol-6-yl)-2-(2H-tetrazol-5-yl)benzenesulfonamide::US9708336, 279 Metallo-beta-lactamase type 2 2166 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262427 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262427&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118257369 376224254 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496435 NCc1nccc2cc(ccc12)-c1cccc(c1-c1nn[nH]n1)S(N)(=O)=O InChI=1S/C17H15N7O2S/c18-9-14-12-5-4-10(8-11(12)6-7-20-14)13-2-1-3-15(27(19,25)26)16(13)17-21-23-24-22-17/h1-8H,9,18H2,(H2,19,25,26)(H,21,22,23,24) NOSBXEYDFQQFLO-UHFFFAOYSA-N 262428 3-(1-(aminomethyl)isoquinolin-6-yl)-2-(2H-tetrazol-5-yl)benzenesulfonamide::US9708336, 280 Metallo-beta-lactamase type 2 15.8 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262428 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262428&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118256859 376224255 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496438 NC(=O)c1nccc2cc(ccc12)-c1cccc(c1-c1nn[nH]n1)S(N)(=O)=O InChI=1S/C17H13N7O3S/c18-16(25)15-12-5-4-9(8-10(12)6-7-20-15)11-2-1-3-13(28(19,26)27)14(11)17-21-23-24-22-17/h1-8H,(H2,18,25)(H2,19,26,27)(H,21,22,23,24) BMTFZBSAMOYHLW-UHFFFAOYSA-N 262429 6-(3-sulfamoyl-2-(2H-tetrazol-5-yl)phenyl)isoquinoline-1-carboxamide::US9708336, 281 Metallo-beta-lactamase type 2 42.9 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262429 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262429&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118257067 376224256 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496441 NC1CNCCC1(O)c1ccc(cc1)-c1cccc(c1-c1nn[nH]n1)S(N)(=O)=O 262430 4′-(3-amino-4-hydroxypiperidin-4-yl)-2-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-3-sulfonamide dihydrochloride (trans, racemate)::US9708336, 282 Metallo-beta-lactamase type 2 266 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262430 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262430&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823591 376224257 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496444 NC1(CCNCC1)c1ccc(cc1)-c1cccc(c1-c1nn[nH]n1)S(N)(=O)=O InChI=1S/C18H21N7O2S/c19-18(8-10-21-11-9-18)13-6-4-12(5-7-13)14-2-1-3-15(28(20,26)27)16(14)17-22-24-25-23-17/h1-7,21H,8-11,19H2,(H2,20,26,27)(H,22,23,24,25) UPJODRHTQLYWFN-UHFFFAOYSA-N 262431 4′-(4-aminopiperidin-4-yl)-2-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-3-sulfonamide dihydrochloride::US9708336, 283 Metallo-beta-lactamase type 2 500 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262431 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262431&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823592 376224258 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496447 NS(=O)(=O)c1cccc(-c2ccc(cc2)C2(O)CCNC2)c1-c1nn[nH]n1 262432 4′-(3-hydroxypyrrolidin-3-yl)-2-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-3-sulfonamide and 4′-(2,5-dihydro-1H-pyrrol-3-yl)-2-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-3-sulfonamide::US9708336, 284 Metallo-beta-lactamase type 2 102 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262432 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262432&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823593 376224259 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496450 NS(=O)(=O)c1cccc(-c2ccc(cc2)C2=CCNC2)c1-c1nn[nH]n1 InChI=1S/C17H16N6O2S/c18-26(24,25)15-3-1-2-14(16(15)17-20-22-23-21-17)12-6-4-11(5-7-12)13-8-9-19-10-13/h1-8,19H,9-10H2,(H2,18,24,25)(H,20,21,22,23) SIMNESNGQIGHKU-UHFFFAOYSA-N 262433 4′-(2,5-dihydro-1H-pyrrol-3-yl)-2-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-3-sulfonamide::US9708336, 285 Metallo-beta-lactamase type 2 25.1 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262433 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262433&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823594 376224260 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496453 NCc1ccc2cc(ccc2n1)-c1cccc(c1-c1nn[nH]n1)S(N)(=O)=O InChI=1S/C17H15N7O2S/c18-9-12-6-4-11-8-10(5-7-14(11)20-12)13-2-1-3-15(27(19,25)26)16(13)17-21-23-24-22-17/h1-8H,9,18H2,(H2,19,25,26)(H,21,22,23,24) DNWKHTRBECRTGB-UHFFFAOYSA-N 262434 3-(2-(aminomethyl)quinolin-6-yl)-2-(2H-tetrazol-5-yl)benzenesulfonamide::US9708336, 286 Metallo-beta-lactamase type 2 204 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262434 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262434&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118256814 376224261 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496456 NS(=O)(=O)c1cccc(-c2ccc3nc(ccc3c2)C(O)=O)c1-c1nn[nH]n1 InChI=1S/C17H12N6O4S/c18-28(26,27)14-3-1-2-11(15(14)16-20-22-23-21-16)9-4-6-12-10(8-9)5-7-13(19-12)17(24)25/h1-8H,(H,24,25)(H2,18,26,27)(H,20,21,22,23) VNGIYBDBGMQECO-UHFFFAOYSA-N 262435 6-(3-sulfamoyl-2-(2H-tetrazol-5-yl)phenyl)quinoline-2-carboxylic acid::US9708336, 287 Metallo-beta-lactamase type 2 159 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262435 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262435&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118256947 376224262 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496459 NC(=O)c1ccc2cc(ccc2n1)-c1cccc(c1-c1nn[nH]n1)S(N)(=O)=O InChI=1S/C17H13N7O3S/c18-16(25)13-7-5-10-8-9(4-6-12(10)20-13)11-2-1-3-14(28(19,26)27)15(11)17-21-23-24-22-17/h1-8H,(H2,18,25)(H2,19,26,27)(H,21,22,23,24) JLHPBTOVJVFJNT-UHFFFAOYSA-N 262436 6-(3-sulfamoyl-2-(2H-tetrazol-5-yl)phenyl)quinoline-2-carboxamide::US9708336, 288 Metallo-beta-lactamase type 2 88.9 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262436 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262436&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118257149 376224263 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496462 NS(=O)(=O)c1cc(Cl)cc(-c2ccc3CNC(=O)c3c2)c1-c1nn[nH]n1 InChI=1S/C15H11ClN6O3S/c16-9-4-10(7-1-2-8-6-18-15(23)11(8)3-7)13(14-19-21-22-20-14)12(5-9)26(17,24)25/h1-5H,6H2,(H,18,23)(H2,17,24,25)(H,19,20,21,22) CZKTXCMLKDPXRH-UHFFFAOYSA-N 262437 5-Chloro-3-(3-oxo-2,3-dihydro-1H-isoindol-5-yl)-2-(2H-tetrazol-5-yl)benzenesulfonamide::US9708336, 289 Metallo-beta-lactamase type 2 121 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262437 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262437&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118256920 376224264 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496465 Cc1ccc(cc1)-c1cc(cc(c1-c1nn[nH]n1)S(N)(=O)=O)-c1ccc2C(=O)NCc2c1 InChI=1S/C22H18N6O3S/c1-12-2-4-13(5-3-12)18-9-15(14-6-7-17-16(8-14)11-24-22(17)29)10-19(32(23,30)31)20(18)21-25-27-28-26-21/h2-10H,11H2,1H3,(H,24,29)(H2,23,30,31)(H,25,26,27,28) IWDIIOPGNBFHOA-UHFFFAOYSA-N 262438 4′-Methyl-5-(1-oxoisoindolin-5-yl)-2-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-3-sulfonamide::US9708336, 290 Metallo-beta-lactamase type 2 19.7 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262438 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262438&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823595 376224265 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496468 Cc1ccc(cc1)-c1cc(cc(c1-c1nn[nH]n1)S(N)(=O)=O)-c1cnn(C)c1 InChI=1S/C18H17N7O2S/c1-11-3-5-12(6-4-11)15-7-13(14-9-20-25(2)10-14)8-16(28(19,26)27)17(15)18-21-23-24-22-18/h3-10H,1-2H3,(H2,19,26,27)(H,21,22,23,24) PIYDYVFHIHQDHD-UHFFFAOYSA-N 262439 4'-methyl-5-(1-methyl-1H- pyrazol-4-yl)-2-(2H-tetrazol- 5-yl)-[1,1'-biphenyl]-3- sulfonamide::US9708336, 291 Metallo-beta-lactamase type 2 98.6 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262439 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262439&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266304 376224266 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496471 Cc1ccc(cc1)-c1cc(cc(c1-c1nn[nH]n1)S(N)(=O)=O)-c1ccc(O)nc1 InChI=1S/C19H16N6O3S/c1-11-2-4-12(5-3-11)15-8-14(13-6-7-17(26)21-10-13)9-16(29(20,27)28)18(15)19-22-24-25-23-19/h2-10H,1H3,(H,21,26)(H2,20,27,28)(H,22,23,24,25) NWTSLAUWCFNYET-UHFFFAOYSA-N 262440 5-(6-hydroxypyridin-3-yl)-4'- methyl-2-(2H-tetrazol-5-yl)- [1,1'-biphenyl]-3-sulfonamide::US9708336, 292 Metallo-beta-lactamase type 2 416 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262440 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262440&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266278 376224267 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496474 Cc1ccc(cc1)-c1cc(cc(c1-c1nn[nH]n1)S(N)(=O)=O)-c1cccnc1 InChI=1S/C19H16N6O2S/c1-12-4-6-13(7-5-12)16-9-15(14-3-2-8-21-11-14)10-17(28(20,26)27)18(16)19-22-24-25-23-19/h2-11H,1H3,(H2,20,26,27)(H,22,23,24,25) FGUDXQJJIVLOIT-UHFFFAOYSA-N 262441 4'-methyl-5-(pyridin-3-yl)-2- (2H-tetrazol-5-yl)-[1,1'- biphenyl]-3-sulfonamide::US9708336, 293 Metallo-beta-lactamase type 2 86.5 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262441 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262441&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266305 376224268 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496477 Cc1ccc(cc1)-c1cc(cc(c1-c1nn[nH]n1)S(N)(=O)=O)-c1ccc2CNCc2c1 InChI=1S/C22H20N6O2S/c1-13-2-4-14(5-3-13)19-9-17(15-6-7-16-11-24-12-18(16)8-15)10-20(31(23,29)30)21(19)22-25-27-28-26-22/h2-10,24H,11-12H2,1H3,(H2,23,29,30)(H,25,26,27,28) GJPIWFFVSZLALY-UHFFFAOYSA-N 262442 5-(isoindolin-5-yl)-4'-methyl- 2-(2H-tetrazol-5-yl)-[1,1'- biphenyl]-3-sulfonamide::US9708336, 294 Metallo-beta-lactamase type 2 29.4 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262442 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262442&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266307 376224269 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496480 Cc1ccc(cc1)-c1cc(cc(c1-c1nn[nH]n1)S(N)(=O)=O)-c1cccc(c1)C(N)=O InChI=1S/C21H18N6O3S/c1-12-5-7-13(8-6-12)17-10-16(14-3-2-4-15(9-14)20(22)28)11-18(31(23,29)30)19(17)21-24-26-27-25-21/h2-11H,1H3,(H2,22,28)(H2,23,29,30)(H,24,25,26,27) BLNABIUHDJSEGE-UHFFFAOYSA-N 262443 4$#8243;-methyl-5'-sulfamoyl-4'- (2H-tetrazol-5-yl)-[1,1':3',1$#8243;- terphenyl]-3-carboxamide::US9708336, 295 Metallo-beta-lactamase type 2 16.1 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262443 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262443&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266192 376224270 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496483 Cc1ccc(cc1)-c1cc(cc(c1-c1nn[nH]n1)S(N)(=O)=O)-c1ccc(cc1)C(N)=O InChI=1S/C21H18N6O3S/c1-12-2-4-14(5-3-12)17-10-16(13-6-8-15(9-7-13)20(22)28)11-18(31(23,29)30)19(17)21-24-26-27-25-21/h2-11H,1H3,(H2,22,28)(H2,23,29,30)(H,24,25,26,27) CSSQSFDPFAFVFE-UHFFFAOYSA-N 262444 4$#8243;-methyl-5'-sulfamoyl-4'- (2H-tetrazol-5-yl)-[1,1':3',1$#8243;- terphenyl]-4-carboxamide::US9708336, 296 Metallo-beta-lactamase type 2 54.8 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262444 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262444&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266255 376224271 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496486 NS(=O)(=O)c1cccc(C(O)=O)c1-c1nn[nH]n1 InChI=1S/C8H7N5O4S/c9-18(16,17)5-3-1-2-4(8(14)15)6(5)7-10-12-13-11-7/h1-3H,(H,14,15)(H2,9,16,17)(H,10,11,12,13) IODGDSIUTPYOMQ-UHFFFAOYSA-N 262445 3-Sulfamoyl-2-(2H-tetrazol-5-yl)benzoic acid::US9708336, 297 Metallo-beta-lactamase type 2 20000 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262445 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262445&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118257005 376224272 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497929 CC(C)(C)c1ccc(N2CCC(N)CC2)c(-c2nnn[nH]2)c1S(N)(=O)=O InChI=1S/C16H25N7O2S/c1-16(2,3)11-4-5-12(23-8-6-10(17)7-9-23)13(14(11)26(18,24)25)15-19-21-22-20-15/h4-5,10H,6-9,17H2,1-3H3,(H2,18,24,25)(H,19,20,21,22) MPAJIAXODIFLIV-UHFFFAOYSA-N 262925 3-(4-amino-1-piperidyl)-2-(1H- tetrazol-5-yl)-6- (trifluoromethyl) benzenesulfonamide::US9708336, 778 Metallo-beta-lactamase type 2 160 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262925 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262925&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823750 376224744 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497932 NS(=O)(=O)c1c(ccc(N2CCC(CC2)C2CCNCC2)c1-c1nnn[nH]1)C(F)(F)F InChI=1S/C18H24F3N7O2S/c19-18(20,21)13-1-2-14(15(16(13)31(22,29)30)17-24-26-27-25-17)28-9-5-12(6-10-28)11-3-7-23-8-4-11/h1-2,11-12,23H,3-10H2,(H2,22,29,30)(H,24,25,26,27) XALPYHVWLHSHEJ-UHFFFAOYSA-N 262926 3-[4-(4-piperidyl)-1-piperidyl]- 2-(1H-tetrazol-5-yl)-6- (trifluoromethyl) benzenesulfonamide::US9708336, 779 Metallo-beta-lactamase type 2 6.70 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262926 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262926&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823751 376224745 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497935 NS(=O)(=O)c1c(ccc(N2CCC(CC2)N2CCNCC2)c1-c1nnn[nH]1)C(F)(F)F InChI=1S/C17H23F3N8O2S/c18-17(19,20)12-1-2-13(14(15(12)31(21,29)30)16-23-25-26-24-16)28-7-3-11(4-8-28)27-9-5-22-6-10-27/h1-2,11,22H,3-10H2,(H2,21,29,30)(H,23,24,25,26) LRSRXELMKIEFQL-UHFFFAOYSA-N 262927 3-(4-piperazin-1-yl-1- piperidyl)-2-(1H-tetrazol-5-yl)- 6- (trifluoromethyl) benzenesulfonamide::US9708336, 780 Metallo-beta-lactamase type 2 31.7 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262927 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262927&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823752 376224746 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497938 NS(=O)(=O)c1c(ccc(N2CC3(C2)CCNCC3)c1-c1nnn[nH]1)C(F)(F)F InChI=1S/C15H18F3N7O2S/c16-15(17,18)9-1-2-10(25-7-14(8-25)3-5-20-6-4-14)11(12(9)28(19,26)27)13-21-23-24-22-13/h1-2,20H,3-8H2,(H2,19,26,27)(H,21,22,23,24) DYFDKHLRRWCZOJ-UHFFFAOYSA-N 262928 3-(2,8-diazaspiro[3.5]nonan-8- yl)-2-(1H-tetrazol-5-yl)-6- (trifluoromethyl) benzenesulfonamide::US9708336, 781::US9708336, 782 Metallo-beta-lactamase type 2 53.7 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262928 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262928&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266468 376224747 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497941 NS(=O)(=O)c1c(ccc(N2CC3(C2)CCNCC3)c1-c1nnn[nH]1)C(F)(F)F InChI=1S/C15H18F3N7O2S/c16-15(17,18)9-1-2-10(25-7-14(8-25)3-5-20-6-4-14)11(12(9)28(19,26)27)13-21-23-24-22-13/h1-2,20H,3-8H2,(H2,19,26,27)(H,21,22,23,24) DYFDKHLRRWCZOJ-UHFFFAOYSA-N 262928 3-(2,8-diazaspiro[3.5]nonan-8- yl)-2-(1H-tetrazol-5-yl)-6- (trifluoromethyl) benzenesulfonamide::US9708336, 781::US9708336, 782 Metallo-beta-lactamase type 2 397 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262928 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262928&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266468 376224747 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497944 NS(=O)(=O)c1c(ccc(N2CCC3(CCNCC3)CC2)c1-c1nnn[nH]1)C(F)(F)F InChI=1S/C17H22F3N7O2S/c18-17(19,20)11-1-2-12(13(14(11)30(21,28)29)15-23-25-26-24-15)27-9-5-16(6-10-27)3-7-22-8-4-16/h1-2,22H,3-10H2,(H2,21,28,29)(H,23,24,25,26) YUYSOLMIPHBCLB-UHFFFAOYSA-N 262930 3-(3,9-diazaspiro[5.5]undecan- 3-yl)-2-(1H-tetrazol-5-yl)-6- (trifluoromethyl) benzenesulfonamide::US9708336, 783 Metallo-beta-lactamase type 2 13.4 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262930 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262930&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266399 376224748 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497947 CN(C)c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)C(F)(F)F InChI=1S/C10H11F3N6O2S/c1-19(2)6-4-3-5(10(11,12)13)8(22(14,20)21)7(6)9-15-17-18-16-9/h3-4H,1-2H3,(H2,14,20,21)(H,15,16,17,18) FNVFJNHEOYCQNC-UHFFFAOYSA-N 262931 3-(dimethylamino)-2-(1H- tetrazol-5-yl)-6- (trifluoromethyl) benzenesulfonamide::US9708336, 784 Metallo-beta-lactamase type 2 48.3 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262931 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262931&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266458 376224749 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497950 NS(=O)(=O)c1c(ccc(-c2ccc(cc2)C2CCN(CC2)C2CCNCC2)c1-c1nnn[nH]1)C(F)(F)F InChI=1S/C24H28F3N7O2S/c25-24(26,27)20-6-5-19(21(22(20)37(28,35)36)23-30-32-33-31-23)17-3-1-15(2-4-17)16-9-13-34(14-10-16)18-7-11-29-12-8-18/h1-6,16,18,29H,7-14H2,(H2,28,35,36)(H,30,31,32,33) YDMCXFWMWSHEBR-UHFFFAOYSA-N 262932 4'-(1,4'-bipiperidin-4-yl)- 2-(1H-tetrazol-5-yl)-4- (trifluoromethyl)biphenyl- 3-sulfonamide::US9708336, 785 Metallo-beta-lactamase type 2 1.09 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262932 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262932&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823753 376224750 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497953 NC1CCC(C1)N1CCC(CC1)c1ccc(cc1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)C(F)(F)F 262933 4'-[1-(3- aminocyclopentyl) piperidin-4-yl]-2-(1H-tetrazol-5- y)-4- (trifluoromethyl)biphenyl- 3-sulfonamide::US9708336, 786 Metallo-beta-lactamase type 2 2.08 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262933 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262933&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823754 376224751 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497956 NCC1CCC(CC1)N1CCC(CC1)c1ccc(cc1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)C(F)(F)F InChI=1S/C26H32F3N7O2S/c27-26(28,29)22-10-9-21(23(24(22)39(31,37)38)25-32-34-35-33-25)19-5-3-17(4-6-19)18-11-13-36(14-12-18)20-7-1-16(15-30)2-8-20/h3-6,9-10,16,18,20H,1-2,7-8,11-15,30H2,(H2,31,37,38)(H,32,33,34,35) AIHGSZBFTGQLQJ-UHFFFAOYSA-N 262934 4'-{1-[4- (aminomethyl)cyclohexyl] piperidin-4-yl}-2-(1H- tetrazol-5-yl)-4- (trifluoromethyl)biphenyl- 3-sulfonamide::US9708336, 787 Metallo-beta-lactamase type 2 1.71 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262934 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262934&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823755 376224752 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497959 NS(=O)(=O)c1c(ccc(-c2ccc(cc2)C2CCN(CC2)C2CC3CCC2N3)c1-c1nnn[nH]1)C(F)(F)F 262935 4'-[1-(7- azabicyclo[2.2.1]hept-2- yl)piperidin-4-yl]-2-(1H- tetrazol-5-yl)-4- (trifluoromethyl)biphenyl- 3-sulfonamide::US9708336, 788 Metallo-beta-lactamase type 2 0.438 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262935 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262935&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823756 376224753 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497962 NS(=O)(=O)c1c(ccc(-c2ccc(cc2)C2CCN(CC2)C2CCNC2)c1-c1nnn[nH]1)C(F)(F)F 262936 4'-(1-pyrrolidin-3- ylpiperidin-4-yl)-2-(1H- tetrazol-5-yl)-4- (trifluoromethyl)biphenyl- 3-sulfonamide::US9708336, 789 Metallo-beta-lactamase type 2 0.472 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262936 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262936&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823757 376224754 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497965 NC1CC(C1)N1CCC(CC1)c1ccc(cc1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)C(F)(F)F InChI=1S/C23H26F3N7O2S/c24-23(25,26)19-6-5-18(20(21(19)36(28,34)35)22-29-31-32-30-22)15-3-1-13(2-4-15)14-7-9-33(10-8-14)17-11-16(27)12-17/h1-6,14,16-17H,7-12,27H2,(H2,28,34,35)(H,29,30,31,32) GYBRZWDIAJISGG-UHFFFAOYSA-N 262937 4'-[1-(3- aminocyclobutyl) piperidin-4-yl]-2-(1H- tetrazol-5-yl)-4- (trifluoromethyl)biphenyl- 3-sulfonamide::US9708336, 790 Metallo-beta-lactamase type 2 0.871 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262937 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262937&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823758 376224755 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497968 NC1CCCC1N1CCC(CC1)c1ccc(cc1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)C(F)(F)F 262938 4'-[1-(2- aminocyclopentyl) piperidin-4-yl]-2-(1H- tetrazol-5-yl)-4- (trifluoromethyl)biphenyl- 3-sulfonamide::US9708336, 791 Metallo-beta-lactamase type 2 1.20 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262938 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262938&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823759 376224756 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497971 NCCC1CCC(CC1)N1CCC(CC1)c1ccc(cc1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)C(F)(F)F InChI=1S/C27H34F3N7O2S/c28-27(29,30)23-10-9-22(24(25(23)40(32,38)39)26-33-35-36-34-26)20-5-3-18(4-6-20)19-12-15-37(16-13-19)21-7-1-17(2-8-21)11-14-31/h3-6,9-10,17,19,21H,1-2,7-8,11-16,31H2,(H2,32,38,39)(H,33,34,35,36) MMCKHPVVCCXYQP-UHFFFAOYSA-N 262939 4'-{1-[4-(2- aminoethyl)cyclohexyl] piperidin-4-yl}-2-(1H- tetrazol-5-yl)-4- (trifluoromethyl)biphenyl- 3-sulfonamide::US9708336, 792 Metallo-beta-lactamase type 2 1.55 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262939 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262939&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823760 376224757 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497974 NS(=O)(=O)c1c(ccc(-c2ccc(cc2)C2CCN(CCC3CCNCC3)CC2)c1-c1nnn[nH]1)C(F)(F)F InChI=1S/C26H32F3N7O2S/c27-26(28,29)22-6-5-21(23(24(22)39(30,37)38)25-32-34-35-33-25)20-3-1-18(2-4-20)19-10-15-36(16-11-19)14-9-17-7-12-31-13-8-17/h1-6,17,19,31H,7-16H2,(H2,30,37,38)(H,32,33,34,35) UUKSLYYLPFNFCV-UHFFFAOYSA-N 262940 4'-[1-(2-piperidin-4- ylethyl)piperidin-4-yl]-2- (1H-tetrazol-5-yl)-4- (trifluoromethyl)biphenyl- 3-sulfonamide::US9708336, 793 Metallo-beta-lactamase type 2 1.02 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262940 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262940&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823761 376224758 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497977 NC1CCC(CC1)N1CCC(CC1)c1ccc(cc1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)C(F)(F)F InChI=1S/C25H30F3N7O2S/c26-25(27,28)21-10-9-20(22(23(21)38(30,36)37)24-31-33-34-32-24)17-3-1-15(2-4-17)16-11-13-35(14-12-16)19-7-5-18(29)6-8-19/h1-4,9-10,16,18-19H,5-8,11-14,29H2,(H2,30,36,37)(H,31,32,33,34) ODBZZPJGRNDCOT-UHFFFAOYSA-N 262941 4'-[1-(4- aminocyclohexyl) piperidin-4-yl]-2-(1H- tetrazol-5-yl)-4- (trifluoromethyl)biphenyl- 3-sulfonamide::US9708336, 794 Metallo-beta-lactamase type 2 1.76 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262941 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262941&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823762 376224759 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497980 NS(=O)(=O)c1c(ccc(-c2ccc(cc2)C2CCN(CC3CCNC3)CC2)c1-c1nnn[nH]1)C(F)(F)F 262942 4'-[1-(pyrrolidin-3- ylmethyl)piperidin-4-yl]- 2-(1H-tetrazol-5-yl)-4- (trifluoromethyl)biphenyl- 3-sulfonamide::US9708336, 795 Metallo-beta-lactamase type 2 1.10 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262942 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262942&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823763 376224760 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497983 NS(=O)(=O)c1c(ccc(-c2ccc(cc2)C2CCN(CC2)C2CNC2)c1-c1nnn[nH]1)C(F)(F)F InChI=1S/C22H24F3N7O2S/c23-22(24,25)18-6-5-17(19(20(18)35(26,33)34)21-28-30-31-29-21)15-3-1-13(2-4-15)14-7-9-32(10-8-14)16-11-27-12-16/h1-6,14,16,27H,7-12H2,(H2,26,33,34)(H,28,29,30,31) XNYAKSAITQEMBK-UHFFFAOYSA-N 262943 4'-(1-azetidin-3- ylpiperidin-4-yl)-2-(1H- tetrazol-5-yl)-4- (trifluoromethyl)biphenyl- 3-sulfonamide::US9708336, 796 Metallo-beta-lactamase type 2 0.345 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262943 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262943&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823764 376224761 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497986 NS(=O)(=O)c1c(ccc(-c2ccc(cc2)C2CCN(CC2)C2CC3(C2)CCNCC3)c1-c1nnn[nH]1)C(F)(F)F InChI=1S/C27H32F3N7O2S/c28-27(29,30)22-6-5-21(23(24(22)40(31,38)39)25-33-35-36-34-25)19-3-1-17(2-4-19)18-7-13-37(14-8-18)20-15-26(16-20)9-11-32-12-10-26/h1-6,18,20,32H,7-16H2,(H2,31,38,39)(H,33,34,35,36) BICVUGRSKSNRRM-UHFFFAOYSA-N 262944 4'-[1-(7-azaspiro[3.5]non- 2-yl)piperidin-4-yl]-2- (1H-tetrazol-5-yl)-4- (trifluoromethyl)biphenyl- 3-sulfonamide::US9708336, 797 Metallo-beta-lactamase type 2 1.51 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262944 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262944&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823765 376224762 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497989 NC1CCCC(C1)N1CCC(CC1)c1ccc(cc1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)C(F)(F)F 262945 4'-[1-(3- aminocyclohexyl) piperidin-4-yl]-2-(1H- tetrazol-5-yl)-4- (trifluoromethyl)biphenyl- 3-sulfonamide::US9708336, 798 Metallo-beta-lactamase type 2 2.35 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262945 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262945&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823766 376224763 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496489 Nc1ccc(cn1)-c1cccc(c1-c1nnn[nH]1)S(N)(=O)=O InChI=1S/C12H11N7O2S/c13-10-5-4-7(6-15-10)8-2-1-3-9(22(14,20)21)11(8)12-16-18-19-17-12/h1-6H,(H2,13,15)(H2,14,20,21)(H,16,17,18,19) QGHCSGQFXJUCGF-UHFFFAOYSA-N 262446 3-(6-Aminopyridin-3-yl)-2-(1H-tetrazol-5-yl)benzene sulfonamide, TFA salt::US9708336, 298 Metallo-beta-lactamase type 2 776 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262446 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262446&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118256780 376224273 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496492 Cc1ccc(cn1)-c1cccc(c1-c1nnn[nH]1)S(N)(=O)=O InChI=1S/C13H12N6O2S/c1-8-5-6-9(7-15-8)10-3-2-4-11(22(14,20)21)12(10)13-16-18-19-17-13/h2-7H,1H3,(H2,14,20,21)(H,16,17,18,19) FAIVFFBCZSPNKG-UHFFFAOYSA-N 262447 3-(6-methylpyridin-3-yl)-2- (1H-tetrazol-5- yl)benzenesulfonamide::US9708336, 299 Metallo-beta-lactamase type 2 444 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262447 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262447&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266182 376224274 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496495 NCCc1ccc(cc1)-c1cccc(c1-c1nnn[nH]1)S(N)(=O)=O InChI=1S/C15H16N6O2S/c16-9-8-10-4-6-11(7-5-10)12-2-1-3-13(24(17,22)23)14(12)15-18-20-21-19-15/h1-7H,8-9,16H2,(H2,17,22,23)(H,18,19,20,21) ZBLRHZURYSERRZ-UHFFFAOYSA-N 262448 4'-(2-aminoethyl)-2-(1H- tetrazol-5-yl)-[1,1'-biphenyl]-3- sulfonamide::US9708336, 300 Metallo-beta-lactamase type 2 373 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262448 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262448&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266187 376224275 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496498 Nc1ncc(cn1)-c1cccc(c1-c1nnn[nH]1)S(N)(=O)=O InChI=1S/C11H10N8O2S/c12-11-14-4-6(5-15-11)7-2-1-3-8(22(13,20)21)9(7)10-16-18-19-17-10/h1-5H,(H2,12,14,15)(H2,13,20,21)(H,16,17,18,19) IXCXYKDJFXFOFS-UHFFFAOYSA-N 262449 3-(2-aminopyrimidin-5-yl)-2- (1H-tetrazol-5- yl)benzenesulfonamide::US9708336, 301 Metallo-beta-lactamase type 2 1383 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262449 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262449&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266189 376224276 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496501 CCCc1ccc(cn1)-c1cccc(c1-c1nnn[nH]1)S(N)(=O)=O InChI=1S/C15H16N6O2S/c1-2-4-11-8-7-10(9-17-11)12-5-3-6-13(24(16,22)23)14(12)15-18-20-21-19-15/h3,5-9H,2,4H2,1H3,(H2,16,22,23)(H,18,19,20,21) PMEUHDZNXKLIAD-UHFFFAOYSA-N 262450 3-(6-propylpyridin-3-yl)-2-(1H- tetrazol-5- yl)benzenesulfonamide::US9708336, 302 Metallo-beta-lactamase type 2 110 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262450 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262450&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266183 376224277 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496504 NC(=O)Cc1ccc(cc1)-c1cccc(c1-c1nnn[nH]1)S(N)(=O)=O InChI=1S/C15H14N6O3S/c16-13(22)8-9-4-6-10(7-5-9)11-2-1-3-12(25(17,23)24)14(11)15-18-20-21-19-15/h1-7H,8H2,(H2,16,22)(H2,17,23,24)(H,18,19,20,21) JPTJCMCWBYLRNP-UHFFFAOYSA-N 262451 2-(3'-sulfamoyl-2'-(1H-tetrazol- 5-yl)-[1,1'-biphenyl]-4- yl)acetamide::US9708336, 303 Metallo-beta-lactamase type 2 59.0 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262451 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262451&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266188 376224278 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496507 Cc1nc2ccccc2n1Cc1ccc(cc1)-c1cccc(c1-c1nnn[nH]1)S(N)(=O)=O InChI=1S/C22H19N7O2S/c1-14-24-18-6-2-3-7-19(18)29(14)13-15-9-11-16(12-10-15)17-5-4-8-20(32(23,30)31)21(17)22-25-27-28-26-22/h2-12H,13H2,1H3,(H2,23,30,31)(H,25,26,27,28) XNBHBVZNWHKKJZ-UHFFFAOYSA-N 262452 4'-((2-methyl-1H- benzo[d]imidazol-1-yl)methyl)- 2-(1H-tetrazol-5-yl)-[1,1'- biphenyl]-3-sulfonamide::US9708336, 304 Metallo-beta-lactamase type 2 50.3 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262452 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262452&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823596 376224279 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496510 NCCCc1ccc(cc1)-c1cccc(c1-c1nnn[nH]1)S(N)(=O)=O InChI=1S/C16H18N6O2S/c17-10-2-3-11-6-8-12(9-7-11)13-4-1-5-14(25(18,23)24)15(13)16-19-21-22-20-16/h1,4-9H,2-3,10,17H2,(H2,18,23,24)(H,19,20,21,22) ZVVCKHMTOBSFMS-UHFFFAOYSA-N 262453 4'-(3-aminopropyl)-2-(1H- tetrazol-5-yl)-[1,1'-biphenyl]-3- sulfonamide::US9708336, 305 Metallo-beta-lactamase type 2 333 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262453 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262453&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266200 376224280 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496513 NCc1ccc(cn1)-c1cccc(c1-c1nnn[nH]1)S(N)(=O)=O InChI=1S/C13H13N7O2S/c14-6-9-5-4-8(7-16-9)10-2-1-3-11(23(15,21)22)12(10)13-17-19-20-18-13/h1-5,7H,6,14H2,(H2,15,21,22)(H,17,18,19,20) NQPPQVZNAJFPCA-UHFFFAOYSA-N 262454 3-(6-(aminomethyl)pyridin-3- yl)-2-(1H-tetrazol-5- yl)benzenesulfonamide::US9708336, 306 Metallo-beta-lactamase type 2 3737 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262454 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262454&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266195 376224281 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496516 NCCc1ccc(cn1)-c1cccc(c1-c1nnn[nH]1)S(N)(=O)=O InChI=1S/C14H15N7O2S/c15-7-6-10-5-4-9(8-17-10)11-2-1-3-12(24(16,22)23)13(11)14-18-20-21-19-14/h1-5,8H,6-7,15H2,(H2,16,22,23)(H,18,19,20,21) PIYQRCCLGOCNCH-UHFFFAOYSA-N 262455 3-(6-(2-aminoethyl)pyridin-3- yl)-2-(1H-tetrazol-5- yl)benzenesulfonamide::US9708336, 307 Metallo-beta-lactamase type 2 4887 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262455 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262455&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266197 376224282 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496519 NS(=O)(=O)c1cccc(-c2ccc(cc2)C#N)c1-c1nnn[nH]1 InChI=1S/C14H10N6O2S/c15-8-9-4-6-10(7-5-9)11-2-1-3-12(23(16,21)22)13(11)14-17-19-20-18-14/h1-7H,(H2,16,21,22)(H,17,18,19,20) OUBRAZIFGXZKSO-UHFFFAOYSA-N 262456 4'-cyano-2-(1H-tetrazol-5-yl)- [1,1'-biphenyl]-3-sulfonamide::US9708336, 308 Metallo-beta-lactamase type 2 192 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262456 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262456&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266194 376224283 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496522 NS(=O)(=O)c1cccc(-c2cnc3[nH]ncc3c2)c1-c1nn[nH]n1 InChI=1S/C13H10N8O2S/c14-24(22,23)10-3-1-2-9(11(10)13-18-20-21-19-13)7-4-8-6-16-17-12(8)15-5-7/h1-6H,(H2,14,22,23)(H,15,16,17)(H,18,19,20,21) UHDNVHRMVOSNRJ-UHFFFAOYSA-N 262457 3-(1H-pyrazolo[3,4-b]pyridin- 5-yl)-2-(2H-tetrazol-5- yl)benzenesulfonamide::US9708336, 309 Metallo-beta-lactamase type 2 326 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262457 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262457&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266097 376224284 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496525 NS(=O)(=O)c1cccc(-c2cnc3cc[nH]c3c2)c1-c1nn[nH]n1 InChI=1S/C14H11N7O2S/c15-24(22,23)12-3-1-2-9(13(12)14-18-20-21-19-14)8-6-11-10(17-7-8)4-5-16-11/h1-7,16H,(H2,15,22,23)(H,18,19,20,21) KRZNPCHQRJYQOO-UHFFFAOYSA-N 262458 3-(1H-pyrrolo[3,2-b]pyridin-6- yl)-2-(2H-tetrazol-5- yl)benzenesulfonamide::US9708336, 310 Metallo-beta-lactamase type 2 420 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262458 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262458&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266099 376224285 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496528 NS(=O)(=O)c1cccc(-c2cnc3ccoc3c2)c1-c1nn[nH]n1 InChI=1S/C14H10N6O3S/c15-24(21,22)12-3-1-2-9(13(12)14-17-19-20-18-14)8-6-11-10(16-7-8)4-5-23-11/h1-7H,(H2,15,21,22)(H,17,18,19,20) QKXYWROJFSXAOZ-UHFFFAOYSA-N 262459 3-(furo[3,2-b]pyridin-6-yl)-2- (2H-tetrazol-5- yl)benzenesulfonamide::US9708336, 311 Metallo-beta-lactamase type 2 129 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262459 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262459&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266108 376224286 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496531 NS(=O)(=O)c1cccc(-c2cnc3[nH]ccc3c2)c1-c1nn[nH]n1 InChI=1S/C14H11N7O2S/c15-24(22,23)11-3-1-2-10(12(11)14-18-20-21-19-14)9-6-8-4-5-16-13(8)17-7-9/h1-7H,(H,16,17)(H2,15,22,23)(H,18,19,20,21) GGSREOYBSXOHDG-UHFFFAOYSA-N 262460 3-(1H-pyrrolo[2,3-b]pyridin-5- yl)-2-(2H-tetrazol-5- yl)benzenesulfonamide::US9708336, 312 Metallo-beta-lactamase type 2 107 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262460 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262460&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266127 376224287 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496534 NS(=O)(=O)c1cccc(-c2ccc3[nH]ncc3c2)c1-c1nn[nH]n1 InChI=1S/C14H11N7O2S/c15-24(22,23)12-3-1-2-10(13(12)14-18-20-21-19-14)8-4-5-11-9(6-8)7-16-17-11/h1-7H,(H,16,17)(H2,15,22,23)(H,18,19,20,21) OLSHDCYSNKLOKH-UHFFFAOYSA-N 262461 3-(1H-indazol-5-yl)-2-(2H- tetrazol-5- yl)benzenesulfonamide::US9708336, 313 Metallo-beta-lactamase type 2 66.9 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262461 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262461&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266110 376224288 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496537 Nc1ncc(cc1F)-c1cccc(c1-c1nn[nH]n1)S(N)(=O)=O InChI=1S/C12H10FN7O2S/c13-8-4-6(5-16-11(8)14)7-2-1-3-9(23(15,21)22)10(7)12-17-19-20-18-12/h1-5H,(H2,14,16)(H2,15,21,22)(H,17,18,19,20) MYNKEVAWZAXHAW-UHFFFAOYSA-N 262462 3-(6-amino-5-fluoropyridin-3- yl)-2-(2H-tetrazol-5- yl)benzenesulfonamide::US9708336, 314 Metallo-beta-lactamase type 2 292 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262462 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262462&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266107 376224289 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496540 NS(=O)(=O)c1cccc(-c2ccc(cc2)C2(O)CNC2)c1-c1nn[nH]n1 InChI=1S/C16H16N6O3S/c17-26(24,25)13-3-1-2-12(14(13)15-19-21-22-20-15)10-4-6-11(7-5-10)16(23)8-18-9-16/h1-7,18,23H,8-9H2,(H2,17,24,25)(H,19,20,21,22) SAMTUYSPYANYGH-UHFFFAOYSA-N 262463 4'-(3-hydroxyazetidin-3-yl)-2- (2H-tetrazol-5-yl)-[1,1'- biphenyl]-3-sulfonamide::US9708336, 315 Metallo-beta-lactamase type 2 510 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262463 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262463&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266131 376224290 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496543 NS(=O)(=O)c1cccc(-c2ccc(OC3CCNCC3)cc2)c1-c1nnn[nH]1 InChI=1S/C18H20N6O3S/c19-28(25,26)16-3-1-2-15(17(16)18-21-23-24-22-18)12-4-6-13(7-5-12)27-14-8-10-20-11-9-14/h1-7,14,20H,8-11H2,(H2,19,25,26)(H,21,22,23,24) DZBDLQANWFORCK-UHFFFAOYSA-N 262464 4'-(piperidin-4-yloxy)-2-(1H- tetrazol-5-yl)-[1,1'-biphenyl]-3- sulfonamide::US9708336, 316 Metallo-beta-lactamase type 2 69.3 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262464 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262464&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266101 376224291 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496546 Cc1ccncc1-c1cccc(c1-c1nn[nH]n1)S(N)(=O)=O InChI=1S/C13H12N6O2S/c1-8-5-6-15-7-10(8)9-3-2-4-11(22(14,20)21)12(9)13-16-18-19-17-13/h2-7H,1H3,(H2,14,20,21)(H,16,17,18,19) TYPPDRKNERPHMN-UHFFFAOYSA-N 262465 3-(4-methylpyridin-3-yl)-2-(2H- tetrazol-5-yl)benzenesulfonamide::US9708336, 317 Metallo-beta-lactamase type 2 360 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262465 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262465&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266134 376224292 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496549 NS(=O)(=O)c1cccc(-c2ccc3nccn3c2)c1-c1nn[nH]n1 InChI=1S/C14H11N7O2S/c15-24(22,23)11-3-1-2-10(13(11)14-17-19-20-18-14)9-4-5-12-16-6-7-21(12)8-9/h1-8H,(H2,15,22,23)(H,17,18,19,20) FDOCCDDYPQGXLJ-UHFFFAOYSA-N 262466 3-(imidazo[1,2-a]pyridin-6-yl)-2- (2H-tetrazol-5- yl)benzenesulfonamide::US9708336, 318 Metallo-beta-lactamase type 2 295 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262466 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262466&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266109 376224293 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497992 CNC1CC(C1)N1CCC(CC1)c1ccc(cc1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)C(F)(F)F InChI=1S/C24H28F3N7O2S/c1-29-17-12-18(13-17)34-10-8-15(9-11-34)14-2-4-16(5-3-14)19-6-7-20(24(25,26)27)22(37(28,35)36)21(19)23-30-32-33-31-23/h2-7,15,17-18,29H,8-13H2,1H3,(H2,28,35,36)(H,30,31,32,33) KTVGSOVNUGSRIM-UHFFFAOYSA-N 262946 4'-{1-[3- (methylamino)cyclobutyl] piperidin-4-yl}-2-(1H- tetrazol-5-yl)-4- (trifluoromethyl)biphenyl- 3-sulfonamide::US9708336, 799 Metallo-beta-lactamase type 2 1.05 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262946 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262946&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823767 376224764 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497995 NS(=O)(=O)c1c(ccc(-c2ccc(cc2)C2CN(CC3CNC3)C2)c1-c1nnn[nH]1)C(F)(F)F InChI=1S/C21H22F3N7O2S/c22-21(23,24)17-6-5-16(18(19(17)34(25,32)33)20-27-29-30-28-20)14-3-1-13(2-4-14)15-10-31(11-15)9-12-7-26-8-12/h1-6,12,15,26H,7-11H2,(H2,25,32,33)(H,27,28,29,30) VBPULBVNJQGDCM-UHFFFAOYSA-N 262947 4'-[1-(azetidin-3- ylmethyl)azetidin-3-yl]-2- (1H-tetrazol-5-yl)-4- (trifluoromethyl)biphenyl- 3-sulfonamide::US9708336, 800 Metallo-beta-lactamase type 2 5.14 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262947 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262947&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823768 376224765 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497998 NS(=O)(=O)c1c(ccc(-c2ccc(cc2)C2CN(C2)C2CCNC2)c1-c1nnn[nH]1)C(F)(F)F 262948 4'-(1-pyrrolidin-3- ylazetidin-3-yl)-2-(1H- tetrazol-5-yl)-4- (trifluoromethyl)biphenyl- 3-sulfonamide::US9708336, 801 Metallo-beta-lactamase type 2 2.80 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262948 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262948&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823769 376224766 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 498001 NS(=O)(=O)c1c(ccc(-c2ccc(cc2)C2CN(C2)C2CCNCC2)c1-c1nnn[nH]1)C(F)(F)F InChI=1S/C22H24F3N7O2S/c23-22(24,25)18-6-5-17(19(20(18)35(26,33)34)21-28-30-31-29-21)14-3-1-13(2-4-14)15-11-32(12-15)16-7-9-27-10-8-16/h1-6,15-16,27H,7-12H2,(H2,26,33,34)(H,28,29,30,31) JKDNIHXLFNEBCI-UHFFFAOYSA-N 262949 4'-(1-piperidin-4- ylazetidin-3-yl)-2-(1H- tetrazol-5-yl)-4- (trifluoromethyl)biphenyl- 3-sulfonamide::US9708336, 802 Metallo-beta-lactamase type 2 4.27 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262949 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262949&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823770 376224767 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 498004 NS(=O)(=O)c1c(ccc(-c2ccc(cc2)C2CN(CCC3CCNCC3)C2)c1-c1nnn[nH]1)C(F)(F)F InChI=1S/C24H28F3N7O2S/c25-24(26,27)20-6-5-19(21(22(20)37(28,35)36)23-30-32-33-31-23)17-3-1-16(2-4-17)18-13-34(14-18)12-9-15-7-10-29-11-8-15/h1-6,15,18,29H,7-14H2,(H2,28,35,36)(H,30,31,32,33) LVOIZDJZDUDPOB-UHFFFAOYSA-N 262950 4'-[1-(2-piperidin-4- ylethyl)azetidin-3-yl]-2- (1H-tetrazol-5-yl)-4- (trifluoromethyl)biphenyl- 3-sulfonamide::US9708336, 803 Metallo-beta-lactamase type 2 13.0 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262950 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262950&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823771 376224768 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 498007 NS(=O)(=O)c1c(ccc(-c2ccc(cc2)C2CN(CC3CCNCC3)C2)c1-c1nnn[nH]1)C(F)(F)F InChI=1S/C23H26F3N7O2S/c24-23(25,26)19-6-5-18(20(21(19)36(27,34)35)22-29-31-32-30-22)16-3-1-15(2-4-16)17-12-33(13-17)11-14-7-9-28-10-8-14/h1-6,14,17,28H,7-13H2,(H2,27,34,35)(H,29,30,31,32) DIPUICMMLCJFIV-UHFFFAOYSA-N 262951 4'-[1-(piperidin-4- ylmethyl)azetidin-3-yl]-2- (1H-tetrazol-5-yl)-4- (trifluoromethyl)biphenyl- 3-sulfonamide::US9708336, 804 Metallo-beta-lactamase type 2 5.78 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262951 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262951&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823772 376224769 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 498010 NS(=O)(=O)c1c(ccc(-c2ccc(cc2)C2CN(C2)C2CC3(C2)CCNCC3)c1-c1nnn[nH]1)C(F)(F)F InChI=1S/C25H28F3N7O2S/c26-25(27,28)20-6-5-19(21(22(20)38(29,36)37)23-31-33-34-32-23)16-3-1-15(2-4-16)17-13-35(14-17)18-11-24(12-18)7-9-30-10-8-24/h1-6,17-18,30H,7-14H2,(H2,29,36,37)(H,31,32,33,34) XPUCZRMEXQMJCD-UHFFFAOYSA-N 262952 4'-[1-(7-azaspiro[3.5]non- 2-yl)azetidin-3-yl]-2-(1H- tetrazol-5-yl)-4- (trifluoromethyl)biphenyl- 3-sulfonamide::US9708336, 805 Metallo-beta-lactamase type 2 7.58 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262952 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262952&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823773 376224770 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 498013 NC1(CN2CC(C2)c2ccc(cc2)-c2ccc(c(c2-c2nnn[nH]2)S(N)(=O)=O)C(F)(F)F)CC1 InChI=1S/C21H22F3N7O2S/c22-21(23,24)16-6-5-15(17(18(16)34(26,32)33)19-27-29-30-28-19)13-3-1-12(2-4-13)14-9-31(10-14)11-20(25)7-8-20/h1-6,14H,7-11,25H2,(H2,26,32,33)(H,27,28,29,30) WSHFVEWNIWELNQ-UHFFFAOYSA-N 262953 4'-{1-[(1- aminocyclopropyl)methyl] azetidin-3-yl}-2-(1H- tetrazol-5-yl)-4- (trifluoromethyl)biphenyl- 3-sulfonamide::US9708336, 806 Metallo-beta-lactamase type 2 7.67 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262953 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262953&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823774 376224771 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 498016 NC1CC(C1)N1CC(C1)c1ccc(cc1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)C(F)(F)F InChI=1S/C21H22F3N7O2S/c22-21(23,24)17-6-5-16(18(19(17)34(26,32)33)20-27-29-30-28-20)12-3-1-11(2-4-12)13-9-31(10-13)15-7-14(25)8-15/h1-6,13-15H,7-10,25H2,(H2,26,32,33)(H,27,28,29,30) ISTUIZINOMEDKH-UHFFFAOYSA-N 262954 4'-[1-(3- aminocyclobutyl)azetidin- 3-yl]-2-(1H-tetrazol-5-yl)- 4- (trifluuromethyl)biphenyl- 3-sulfonamide::US9708336, 807 Metallo-beta-lactamase type 2 5.16 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262954 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262954&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823775 376224772 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 498019 NC1CCC(C1)N1CC(C1)c1ccc(cc1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)C(F)(F)F 262955 4'-[1-(3- aminocyclopentyl)azetidin- 3-yl]-2-(1H-tetrazol-5- yl)-4- (trifluoromethyl)biphenyl- 3-sulfonamide::US9708336, 808 Metallo-beta-lactamase type 2 8.44 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262955 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262955&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823776 376224773 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 498022 NC1CCC(CC1)N1CC(C1)c1ccc(cc1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)C(F)(F)F InChI=1S/C23H26F3N7O2S/c24-23(25,26)19-10-9-18(20(21(19)36(28,34)35)22-29-31-32-30-22)14-3-1-13(2-4-14)15-11-33(12-15)17-7-5-16(27)6-8-17/h1-4,9-10,15-17H,5-8,11-12,27H2,(H2,28,34,35)(H,29,30,31,32) ZKPJIYOTGWRHNB-UHFFFAOYSA-N 262956 4'-[1-(4- aminocyclohexyl)azetidin- 3-yl]-2-(1H-tetrazol-5-yl)- 4- (trifluoromethyl)biphenyl- 3-sulfonamide::US9708336, 809 Metallo-beta-lactamase type 2 11.3 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262956 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262956&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823777 376224774 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 498025 NC1CCCC(C1)N1CC(C1)c1ccc(cc1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)C(F)(F)F 262957 4'-[1-(3- aminocyclohexyl)azetidin- 3-yl]-2-(1H-tetrazol-5-yl)- 4- (trifluoromethyl)biphenyl- 3-sulfonamide::US9708336, 810 Metallo-beta-lactamase type 2 8.92 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262957 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262957&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823778 376224775 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 498028 NC1CCCC1N1CC(C1)c1ccc(cc1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)C(F)(F)F 262958 4'-[1-(2- aminocyclopentyl) azetidin-3-yl]-2- (1H-tetrazol-5-yl)-4- (trifluoromethyl)biphenyl- 3-sulfonamide::US9708336, 811 Metallo-beta-lactamase type 2 9.42 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262958 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262958&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823779 376224776 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 498031 NCCN1CC(C1)c1ccc(cc1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)C(F)(F)F InChI=1S/C19H20F3N7O2S/c20-19(21,22)15-6-5-14(16(17(15)32(24,30)31)18-25-27-28-26-18)12-3-1-11(2-4-12)13-9-29(10-13)8-7-23/h1-6,13H,7-10,23H2,(H2,24,30,31)(H,25,26,27,28) AKPIBGFSNOMEIE-UHFFFAOYSA-N 262959 4'-[1-(2- aminoethyl)azetidin-3-yl]- 2-(1H-tetrazol-5-yl)-4- (trifluoromethyl)biphenyl- 3-sulfonamide::US9708336, 812 Metallo-beta-lactamase type 2 5.77 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262959 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262959&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823780 376224777 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 498034 NCC1CCC(CC1)N1CC(C1)c1ccc(cc1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)C(F)(F)F InChI=1S/C24H28F3N7O2S/c25-24(26,27)20-10-9-19(21(22(20)37(29,35)36)23-30-32-33-31-23)16-5-3-15(4-6-16)17-12-34(13-17)18-7-1-14(11-28)2-8-18/h3-6,9-10,14,17-18H,1-2,7-8,11-13,28H2,(H2,29,35,36)(H,30,31,32,33) WKZJATJJURVIKZ-UHFFFAOYSA-N 262960 4'-{1-[4- (aminomethyl)cyclohexyl] azetidin-3-yl}-2-(1H- tetrazol-5-yl)-4- (trifluoromethyl)biphenyl- 3-sulfonamide::US9708336, 813 Metallo-beta-lactamase type 2 9.86 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262960 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262960&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823781 376224778 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 498037 NCCC1CCC(CC1)N1CC(C1)c1ccc(cc1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)C(F)(F)F InChI=1S/C25H30F3N7O2S/c26-25(27,28)21-10-9-20(22(23(21)38(30,36)37)24-31-33-34-32-24)17-5-3-16(4-6-17)18-13-35(14-18)19-7-1-15(2-8-19)11-12-29/h3-6,9-10,15,18-19H,1-2,7-8,11-14,29H2,(H2,30,36,37)(H,31,32,33,34) XMWUYROQLZJHQF-UHFFFAOYSA-N 262961 4'-{1-[4-(2- aminoethyl)cyclohexyl] azetidin-3-yl}-2-(1H- tetrazol-5-yl)-4- (trifluoromethyl)biphenyl- 3-sulfonamide::US9708336, 814 Metallo-beta-lactamase type 2 12.5 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262961 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262961&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823782 376224779 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 498040 CNC1CC(C1)N1CC(C1)c1ccc(cc1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)C(F)(F)F InChI=1S/C22H24F3N7O2S/c1-27-15-8-16(9-15)32-10-14(11-32)12-2-4-13(5-3-12)17-6-7-18(22(23,24)25)20(35(26,33)34)19(17)21-28-30-31-29-21/h2-7,14-16,27H,8-11H2,1H3,(H2,26,33,34)(H,28,29,30,31) OELQBQUHOXMUEO-UHFFFAOYSA-N 262962 4'-{1-[3- (methylamino)cyclobutyl] azetidin-3-yl}-2-(1H- tetrazol-5-yl)-4- (trifluoromethyl)biphenyl- 3-sulfonamide::US9708336, 815 Metallo-beta-lactamase type 2 6.01 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262962 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262962&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823783 376224780 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 498043 NCCCN1CC(C1)c1ccc(cc1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)C(F)(F)F InChI=1S/C20H22F3N7O2S/c21-20(22,23)16-7-6-15(17(18(16)33(25,31)32)19-26-28-29-27-19)13-4-2-12(3-5-13)14-10-30(11-14)9-1-8-24/h2-7,14H,1,8-11,24H2,(H2,25,31,32)(H,26,27,28,29) WFOJCSGWLHHGIW-UHFFFAOYSA-N 262963 4'-[1-(3- aminopropyl)azetidin-3- yl]-2-(1H-tetrazol-5-yl)-4- (trifluoromethyl)biphenyl- 3-sulfonamide::US9708336, 816 Metallo-beta-lactamase type 2 16.3 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262963 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262963&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823784 376224781 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 498046 NCCCCN1CC(C1)c1ccc(cc1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)C(F)(F)F InChI=1S/C21H24F3N7O2S/c22-21(23,24)17-8-7-16(18(19(17)34(26,32)33)20-27-29-30-28-20)14-5-3-13(4-6-14)15-11-31(12-15)10-2-1-9-25/h3-8,15H,1-2,9-12,25H2,(H2,26,32,33)(H,27,28,29,30) YTTIHDLKIWVNPI-UHFFFAOYSA-N 262964 4'-[1-(4- aminobutyl)azetidin-3-yl]- 2-(1H-tetrazol-5-yl)-4- (trifluoromethyl)biphenyl- 3-sulfonamide::US9708336, 817 Metallo-beta-lactamase type 2 15.0 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262964 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262964&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823785 376224782 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 498049 NS(=O)(=O)c1c(ccc(-c2ccc(cc2)C2CN(CC3CCNC3)C2)c1-c1nnn[nH]1)C(F)(F)F 262965 4'-[1-(pyrrolidin-3- ylmethyl)azetidin-3-yl]-2- (1H-tetrazol-5-yl)-4- (trifluoromethyl)biphenyl- 3-sulfonamide::US9708336, 818 Metallo-beta-lactamase type 2 8.60 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262965 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262965&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823786 376224783 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 498052 N[C@H]1CC[C@H](CC1)c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)C(F)(F)F 262966 3-((1s,4s)-4-aminocyclohexyl)-2-(1H-tetrazol-5-yl)-6-(trifluoromethyl)benzenesulfonamide::US9708336, 819 Metallo-beta-lactamase type 2 97.1 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262966 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262966&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266354 376224784 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 498055 N[C@H]1CC[C@@H](CC1)c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)C(F)(F)F 262967 3-((1r,4r)-4-aminocyclohexyl)-2-(1H-tetrazol-5-yl)-6-(trifluoromethyl)benzenesulfonamide::US9708336, 820 Metallo-beta-lactamase type 2 39.4 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262967 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262967&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266354 376224785 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496552 NS(=O)(=O)c1cccc(-c2ccnc3ccccc23)c1-c1nn[nH]n1 InChI=1S/C16H12N6O2S/c17-25(23,24)14-7-3-5-12(15(14)16-19-21-22-20-16)10-8-9-18-13-6-2-1-4-11(10)13/h1-9H,(H2,17,23,24)(H,19,20,21,22) WISWQAGRBCJTBN-UHFFFAOYSA-N 262467 3-(quinolin-4-yl)-2-(2H-tetrazol- 5-yl)benzenesulfonamide::US9708336, 319 Metallo-beta-lactamase type 2 62.2 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262467 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262467&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266136 376224294 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496555 NS(=O)(=O)c1cccc(-c2cnc(nc2)N2CCNCC2)c1-c1nn[nH]n1 InChI=1S/C15H17N9O2S/c16-27(25,26)12-3-1-2-11(13(12)14-20-22-23-21-14)10-8-18-15(19-9-10)24-6-4-17-5-7-24/h1-3,8-9,17H,4-7H2,(H2,16,25,26)(H,20,21,22,23) PJGHBBZQHYSEGM-UHFFFAOYSA-N 262468 3-(2-(Piperazin-1-yl)pyrimidin-5-yl)-2-(2H-tetrazol-5-yl)benzenesulfonamide::US9708336, 320 Metallo-beta-lactamase type 2 294 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262468 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262468&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118256941 376224295 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496558 NS(=O)(=O)c1cccc(-c2ccc(cc2)C(O)CO)c1-c1nn[nH]n1 262469 4'-(1,2-dihydroxyethyl)-2-(2H- tetrazol-5-yl)-[1,1'-biphenyl]-3- sulfonamide::US9708336, 321 Metallo-beta-lactamase type 2 93.5 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262469 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262469&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266112 376224296 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496561 NS(=O)(=O)c1cccc(-c2ccc(nc2)N2CCCCC2)c1-c1nn[nH]n1 InChI=1S/C17H19N7O2S/c18-27(25,26)14-6-4-5-13(16(14)17-20-22-23-21-17)12-7-8-15(19-11-12)24-9-2-1-3-10-24/h4-8,11H,1-3,9-10H2,(H2,18,25,26)(H,20,21,22,23) VKLYJHJXFLRBBL-UHFFFAOYSA-N 262470 3-(6-(piperidin-1-yl)pyridin-3- yl)-2-(2H-tetrazol-5- yl)benzenesulfonamide::US9708336, 322 Metallo-beta-lactamase type 2 321 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262470 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262470&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266104 376224297 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496564 NS(=O)(=O)c1cccc(-c2ccc(nc2)N2CCOCC2)c1-c1nn[nH]n1 InChI=1S/C16H17N7O3S/c17-27(24,25)13-3-1-2-12(15(13)16-19-21-22-20-16)11-4-5-14(18-10-11)23-6-8-26-9-7-23/h1-5,10H,6-9H2,(H2,17,24,25)(H,19,20,21,22) MLEFBNZSOZHHQX-UHFFFAOYSA-N 262471 3-(6-morpholinopyridin-3-yl)- 2-(2H-tetrazol-5- yl)benzenesulfonamide::US9708336, 323 Metallo-beta-lactamase type 2 70.6 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262471 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262471&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266116 376224298 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496567 NS(=O)(=O)c1cccc(-c2ccc(nc2)N2CCNCC2)c1-c1nn[nH]n1 InChI=1S/C16H18N8O2S/c17-27(25,26)13-3-1-2-12(15(13)16-20-22-23-21-16)11-4-5-14(19-10-11)24-8-6-18-7-9-24/h1-5,10,18H,6-9H2,(H2,17,25,26)(H,20,21,22,23) QSGSGAUWEVWJHV-UHFFFAOYSA-N 262472 3-(6-(piperazin-1-yl)pyridin-3- yl)-2-(2H-tetrazol-5- yl)benzenesulfonamide::US9708336, 324 Metallo-beta-lactamase type 2 1022 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262472 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262472&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 122687969 376224299 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496570 Cc1ccccc1-c1cccc(c1-c1nn[nH]n1)S(N)(=O)=O InChI=1S/C14H13N5O2S/c1-9-5-2-3-6-10(9)11-7-4-8-12(22(15,20)21)13(11)14-16-18-19-17-14/h2-8H,1H3,(H2,15,20,21)(H,16,17,18,19) FTZPSUKIIDCWKF-UHFFFAOYSA-N 262473 2'-methyl-2-(2H-tetrazol-5-yl)- [1,1'-biphenyl]-3-sulfonamide::US9708336, 325 Metallo-beta-lactamase type 2 228 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262473 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262473&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266118 376224300 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496573 NS(=O)(=O)c1cccc(-c2ccccc2O)c1-c1nn[nH]n1 InChI=1S/C13H11N5O3S/c14-22(20,21)11-7-3-5-9(8-4-1-2-6-10(8)19)12(11)13-15-17-18-16-13/h1-7,19H,(H2,14,20,21)(H,15,16,17,18) GKXTZZLTSMMLCA-UHFFFAOYSA-N 262474 2'-hydroxy-2-(2H-tetrazol-5- yl)-[1,1'-biphenyl]-3- sulfonamide::US9708336, 326 Metallo-beta-lactamase type 2 370 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262474 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262474&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 119080000 376224301 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496576 CN(C)Cc1ccc(cc1)-c1cccc(c1-c1nnn[nH]1)S(N)(=O)=O InChI=1S/C16H18N6O2S/c1-22(2)10-11-6-8-12(9-7-11)13-4-3-5-14(25(17,23)24)15(13)16-18-20-21-19-16/h3-9H,10H2,1-2H3,(H2,17,23,24)(H,18,19,20,21) WPDHJFFFKZQDKO-UHFFFAOYSA-N 262475 4′-((Dimethylamino)methyl)-2-(1H-tetrazol-5-yl)-[1,1′-biphenyl]-3-sulfonamide, TFA salt::US9708336, 327 Metallo-beta-lactamase type 2 534 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262475 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262475&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118256787 376224302 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496579 NS(=O)(=O)c1cccc(-c2ccc(CNCCN3CCCC3)cc2)c1-c1nn[nH]n1 InChI=1S/C20H25N7O2S/c21-30(28,29)18-5-3-4-17(19(18)20-23-25-26-24-20)16-8-6-15(7-9-16)14-22-10-13-27-11-1-2-12-27/h3-9,22H,1-2,10-14H2,(H2,21,28,29)(H,23,24,25,26) PANXSMZJLSPQLT-UHFFFAOYSA-N 262476 4'-(((2-(pyrrolidin-1- yl)ethyl)amino)methyl)-2- (2H-tetrazol-5-yl)-[1,1'- biphenyl]-3-sulfonamide::US9708336, 328 Metallo-beta-lactamase type 2 325 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262476 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262476&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266106 376224303 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496582 CN1CCN(Cc2ccc(cc2)-c2cccc(c2-c2nnn[nH]2)S(N)(=O)=O)CC1 InChI=1S/C19H23N7O2S/c1-25-9-11-26(12-10-25)13-14-5-7-15(8-6-14)16-3-2-4-17(29(20,27)28)18(16)19-21-23-24-22-19/h2-8H,9-13H2,1H3,(H2,20,27,28)(H,21,22,23,24) MAYGQBCAQXBEGH-UHFFFAOYSA-N 262477 4'-((4-methylpiperazin-1- yl)methyl)-2-(1H-tetrazol-5- yl)-[1,1'-biphenyl]-3- sulfonamide::US9708336, 329 Metallo-beta-lactamase type 2 87.1 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262477 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262477&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266094 376224304 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496585 NS(=O)(=O)c1cccc(-c2ccc(CNCC(=O)NO)cc2)c1-c1nnn[nH]1 InChI=1S/C16H17N7O4S/c17-28(26,27)13-3-1-2-12(15(13)16-19-22-23-20-16)11-6-4-10(5-7-11)8-18-9-14(24)21-25/h1-7,18,25H,8-9H2,(H,21,24)(H2,17,26,27)(H,19,20,22,23) RVFKAPUNJQJWPM-UHFFFAOYSA-N 262478 N-hydroxy-2-(((3'- sulfamoyl-2'-(1H-tetrazol-5- yl)-[1,1'-biphenyl]-4- yl)methyl)amino)acetamide::US9708336, 330 Metallo-beta-lactamase type 2 118 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262478 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262478&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266545 376224305 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496588 CN1CC(C1)NCc1ccc(cc1)-c1cccc(c1-c1nnn[nH]1)S(N)(=O)=O InChI=1S/C18H21N7O2S/c1-25-10-14(11-25)20-9-12-5-7-13(8-6-12)15-3-2-4-16(28(19,26)27)17(15)18-21-23-24-22-18/h2-8,14,20H,9-11H2,1H3,(H2,19,26,27)(H,21,22,23,24) HTTRGEBMENRFOT-UHFFFAOYSA-N 262479 4'-(((1-methylazetidin-3- yl)amino)methyl)-2-(1H- tetrazol-5-yl)-[1,1'- biphenyl]-3-sulfonamide::US9708336, 331 Metallo-beta-lactamase type 2 392 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262479 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262479&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266548 376224306 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496591 CN1CCC(C1)NCc1ccc(cc1)-c1cccc(c1-c1nnn[nH]1)S(N)(=O)=O 262480 4'-(((1-methylpyrrolidin-3- yl)amino)methyl)-2-(1H- tetrazol-5-yl)-[1,1'- biphenyl]-3-sulfonamide::US9708336, 332 Metallo-beta-lactamase type 2 192 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262480 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262480&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266546 376224307 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496594 Cn1cnc(CNCc2ccc(cc2)-c2cccc(c2-c2nnn[nH]2)S(N)(=O)=O)c1 InChI=1S/C19H20N8O2S/c1-27-11-15(22-12-27)10-21-9-13-5-7-14(8-6-13)16-3-2-4-17(30(20,28)29)18(16)19-23-25-26-24-19/h2-8,11-12,21H,9-10H2,1H3,(H2,20,28,29)(H,23,24,25,26) CBUKEEQWWCFSNN-UHFFFAOYSA-N 262481 4'-((((1-methyl-1H-imidazol- 4-yl)methyl)amino)methyl)- 2-(1H-tetrazol-5-yl)-[1,1'- biphenyl]-3-sulfonamide::US9708336, 333 Metallo-beta-lactamase type 2 186 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262481 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262481&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266544 376224308 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496597 CNCc1ccc(cc1)-c1cccc(c1-c1nnn[nH]1)S(N)(=O)=O InChI=1S/C15H16N6O2S/c1-17-9-10-5-7-11(8-6-10)12-3-2-4-13(24(16,22)23)14(12)15-18-20-21-19-15/h2-8,17H,9H2,1H3,(H2,16,22,23)(H,18,19,20,21) MPBYUCBNSPDXCT-UHFFFAOYSA-N 262482 4'-((methylamino)methyl)-2- (1H-tetrazol-5-yl)-[1,1'- biphenyl]-3-sulfonamide::US9708336, 334 Metallo-beta-lactamase type 2 385 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262482 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262482&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266547 376224309 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496600 CN(CCO)Cc1ccc(cc1)-c1cccc(c1-c1nnn[nH]1)S(N)(=O)=O InChI=1S/C17H20N6O3S/c1-23(9-10-24)11-12-5-7-13(8-6-12)14-3-2-4-15(27(18,25)26)16(14)17-19-21-22-20-17/h2-8,24H,9-11H2,1H3,(H2,18,25,26)(H,19,20,21,22) ZNNCOOBRZCUJKO-UHFFFAOYSA-N 262483 4'-(((2- hydroxyethyl)(methyl)amino) methyl)-2-(1H-tetrazol-5- yl)-[1,1'-biphenyl]-3- sulfonamide::US9708336, 335 Metallo-beta-lactamase type 2 228 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262483 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262483&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266549 376224310 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496603 CC(C)(O)C1CN(Cc2ccc(cc2)-c2cccc(c2-c2nnn[nH]2)S(N)(=O)=O)C1 InChI=1S/C20H24N6O3S/c1-20(2,27)15-11-26(12-15)10-13-6-8-14(9-7-13)16-4-3-5-17(30(21,28)29)18(16)19-22-24-25-23-19/h3-9,15,27H,10-12H2,1-2H3,(H2,21,28,29)(H,22,23,24,25) UUNBRNOPSGWILC-UHFFFAOYSA-N 262484 4'-((3-(2-hydroxypropan-2- yl)azetidin-1-yl)methyl)-2- (1H-tetrazol-5-yl)-[1,1'- biphenyl]-3-sulfonamide::US9708336, 336 Metallo-beta-lactamase type 2 379 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262484 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262484&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118265929 376224311 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496606 NC(=O)C1CCN(Cc2ccc(cc2)-c2cccc(c2-c2nnn[nH]2)S(N)(=O)=O)C1 262485 1-((3'-sulfamoyl-2'-(1H- tetrazol-5-yl)-[1,1'- biphenyl]-4- yl)methyl)pyrrolidine-3- carboxamide::US9708336, 337 Metallo-beta-lactamase type 2 69.8 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262485 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262485&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118265931 376224312 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496609 NS(=O)(=O)c1cccc(-c2ccc(CNCCc3nc[nH]n3)cc2)c1-c1nnn[nH]1 InChI=1S/C18H19N9O2S/c19-30(28,29)15-3-1-2-14(17(15)18-24-26-27-25-18)13-6-4-12(5-7-13)10-20-9-8-16-21-11-22-23-16/h1-7,11,20H,8-10H2,(H2,19,28,29)(H,21,22,23)(H,24,25,26,27) HWDAATFCCFUKOS-UHFFFAOYSA-N 262486 4'-(((2-(1H-1,2,4-triazol-3- yl)ethyl)amino)methyl)-2- (1H-tetrazol-5-yl)-[1,1'- biphenyl]-3-sulfonamide::US9708336, 338 Metallo-beta-lactamase type 2 75.4 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262486 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262486&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823597 376224313 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496612 NS(=O)(=O)c1cccc(-c2ccc(CNC3CC(F)(F)C3)cc2)c1-c1nnn[nH]1 InChI=1S/C18H18F2N6O2S/c19-18(20)8-13(9-18)22-10-11-4-6-12(7-5-11)14-2-1-3-15(29(21,27)28)16(14)17-23-25-26-24-17/h1-7,13,22H,8-10H2,(H2,21,27,28)(H,23,24,25,26) DZCHOFJQHMLORX-UHFFFAOYSA-N 262487 4'-(((3,3- difluorocyclobutyl)amino) methyl)-2-(1H-tetrazol-5-yl)- [1,1'-biphenyl]-3- sulfonamide::US9708336, 339 Metallo-beta-lactamase type 2 42.3 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262487 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262487&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118265926 376224314 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496615 NC(=O)CNCc1ccc(cc1)-c1cccc(c1-c1nnn[nH]1)S(N)(=O)=O InChI=1S/C16H17N7O3S/c17-14(24)9-19-8-10-4-6-11(7-5-10)12-2-1-3-13(27(18,25)26)15(12)16-20-22-23-21-16/h1-7,19H,8-9H2,(H2,17,24)(H2,18,25,26)(H,20,21,22,23) YVQPUMJCEBSVST-UHFFFAOYSA-N 262488 2-(((3'-sulfamoyl-2'-(1H- tetrazol-5-yl)-[1,1'- biphenyl]-4- yl)methyl)amino)acetamide::US9708336, 340 Metallo-beta-lactamase type 2 90.2 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262488 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262488&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118265934 376224315 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 498058 NCC1CCN(CC1)c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)C(F)(F)F InChI=1S/C14H18F3N7O2S/c15-14(16,17)9-1-2-10(24-5-3-8(7-18)4-6-24)11(12(9)27(19,25)26)13-20-22-23-21-13/h1-2,8H,3-7,18H2,(H2,19,25,26)(H,20,21,22,23) TZHGRINJTNGFCN-UHFFFAOYSA-N 262968 3-[4-(aminomethyl)-1-piperidyl]-2-(1H-tetrazol-5-yl)-6-(trifluoromethyl)benzenesulfonamide::US9708336, 821 Metallo-beta-lactamase type 2 55.1 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262968 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262968&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118257105 376224786 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 498061 NC(=N)N1CCC2(CC1)CCN(CC2)c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)C(F)(F)F InChI=1S/C18H24F3N9O2S/c19-18(20,21)11-1-2-12(13(14(11)33(24,31)32)15-25-27-28-26-15)29-7-3-17(4-8-29)5-9-30(10-6-17)16(22)23/h1-2H,3-10H2,(H3,22,23)(H2,24,31,32)(H,25,26,27,28) OUSYRGFGEKGPNY-UHFFFAOYSA-N 262969 9-[3-sulfamoyl-2-(1H-tetrazol-5-yl)- 4-(trifluoromethyl)phenyl]-3,9- diazaspiro[5.5]undecane-3- carboxamidine::US9708336, 822 Metallo-beta-lactamase type 2 2.25 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262969 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262969&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823787 376224787 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 498064 NC(=N)N[C@H]1CC[C@@H](CC1)c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)C(F)(F)F 262970 1-[4-[3-sulfamoyl-2-(1H-tetrazol-5- yl)-4- (trifluoromethyl)phenyl]cyclohexyl] guanidine::US9708336, 823 Metallo-beta-lactamase type 2 25.4 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262970 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262970&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266375 376224788 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 498067 NC(=N)NC1CCN(CC1)c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)C(F)(F)F InChI=1S/C14H18F3N9O2S/c15-14(16,17)8-1-2-9(26-5-3-7(4-6-26)21-13(18)19)10(11(8)29(20,27)28)12-22-24-25-23-12/h1-2,7H,3-6H2,(H4,18,19,21)(H2,20,27,28)(H,22,23,24,25) PYHPETJUINYOHD-UHFFFAOYSA-N 262971 1-[1-[3-sulfamoyl-2-(1H-tetrazol-5- yl)-4-(trifluoromethyl)phenyl]-4- piperidyl]guanidine::US9708336, 824 Metallo-beta-lactamase type 2 59.2 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262971 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262971&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266381 376224789 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 498070 NC(=N)N1CCC(CC1)[C@H]1CC[C@@H](CC1)c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)C(F)(F)F 262972 4-[4-[3-sulfamoyl-2-(1H-tetrazol-5- yl)-4- (trifluoromethyl)phenyl]cyclohexyl] piperidine-1-carboxamidine::US9708336, 825 Metallo-beta-lactamase type 2 0.499 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262972 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262972&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266357 376224790 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 498073 NC(=N)N1CCC2(CCC(CC2)c2ccc(c(c2-c2nnn[nH]2)S(N)(=O)=O)C(F)(F)F)CC1 InChI=1S/C19H25F3N8O2S/c20-19(21,22)13-2-1-12(14(15(13)33(25,31)32)16-26-28-29-27-16)11-3-5-18(6-4-11)7-9-30(10-8-18)17(23)24/h1-2,11H,3-10H2,(H3,23,24)(H2,25,31,32)(H,26,27,28,29) AXPTXASLHIWRCG-UHFFFAOYSA-N 262973 9-[3-sulfamoyl-2-(1H-tetrazol-5-yl)- 4-(trifluoromethyl)phenyl]-3- azaspiro[5.5]undecane-3- carboxamidine::US9708336, 826 Metallo-beta-lactamase type 2 1.45 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262973 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262973&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266382 376224791 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 498076 NCCNC1CCC(CC1)c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)C(F)(F)F InChI=1S/C16H22F3N7O2S/c17-16(18,19)12-6-5-11(9-1-3-10(4-2-9)22-8-7-20)13(14(12)29(21,27)28)15-23-25-26-24-15/h5-6,9-10,22H,1-4,7-8,20H2,(H2,21,27,28)(H,23,24,25,26) JLQGFVBEVXERPD-UHFFFAOYSA-N 262974 3-[4-(trans-2-aminoethylamino)cyclohexyl]-2-(1H-tetrazol-5-yl)-6-(trifluoromethyl)benzenesulfonamide::US9708336, 827 Metallo-beta-lactamase type 2 22.6 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262974 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262974&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118257280 376224792 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 498079 NCCNC1CCC(CC1)c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)C(F)(F)F InChI=1S/C16H22F3N7O2S/c17-16(18,19)12-6-5-11(9-1-3-10(4-2-9)22-8-7-20)13(14(12)29(21,27)28)15-23-25-26-24-15/h5-6,9-10,22H,1-4,7-8,20H2,(H2,21,27,28)(H,23,24,25,26) JLQGFVBEVXERPD-UHFFFAOYSA-N 262975 3-((1s,4s)-4-((2-aminoethyl)amino)cyclohexyl)-2-(1H-tetrazol-5-yl)-6-(trifluoromethyl)benzenesulfonamide::US9708336, 828 Metallo-beta-lactamase type 2 72.9 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262975 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262975&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118257280 376224793 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 498082 NCCNC1CCN(CC1)c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)C(F)(F)F InChI=1S/C15H21F3N8O2S/c16-15(17,18)10-1-2-11(26-7-3-9(4-8-26)21-6-5-19)12(13(10)29(20,27)28)14-22-24-25-23-14/h1-2,9,21H,3-8,19H2,(H2,20,27,28)(H,22,23,24,25) UXSDPJWOSJEEOI-UHFFFAOYSA-N 262976 3-[4-(2-aminoethylamino)-1-piperidyl]-2-(1H-tetrazol-5-yl)-6-(trifluoromethyl)benzenesulfonamide::US9708336, 829 Metallo-beta-lactamase type 2 93.3 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262976 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262976&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266330 376224794 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 498085 NC1(CNC2CCC(CC2)c2ccc(c(c2-c2nnn[nH]2)S(N)(=O)=O)C(F)(F)F)CC1 InChI=1S/C18H24F3N7O2S/c19-18(20,21)13-6-5-12(14(15(13)31(23,29)30)16-25-27-28-26-16)10-1-3-11(4-2-10)24-9-17(22)7-8-17/h5-6,10-11,24H,1-4,7-9,22H2,(H2,23,29,30)(H,25,26,27,28) NUJCSSBUQXLEAO-UHFFFAOYSA-N 262977 3-[4-[(1-aminocyclopropyl)methylamino]cyclohexyl]-2-(1H-tetrazol-5-yl)-6-(trifluoromethyl)benzenesulfonamide::US9708336, 830 Metallo-beta-lactamase type 2 3.82 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262977 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262977&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118257195 376224795 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 498088 NS(=O)(=O)c1c(ccc([C@H]2CC[C@@H](CC2)C2CCNCC2)c1-c1nnn[nH]1)C(F)(F)F 262978 3-((1s,4s)-4-(piperidin-4-yl)cyclohexyl)-2-(1H-tetrazol-5-yl)-6-(trifluoromethyl)benzenesulfonamide::US9708336, 831 Metallo-beta-lactamase type 2 0.892 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262978 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262978&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118256794 376224796 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 498091 NS(=O)(=O)c1c(ccc([C@H]2CCC(CC2)C2CCNCC2)c1-c1nnn[nH]1)C(F)(F)F 262979 3-((1r,4r)-4-(piperidin-4-yl)cyclohexyl)-2-(1H-tetrazol-5-yl)-6-(trifluoromethyl)benzenesulfonamide::US9708336, 832 Metallo-beta-lactamase type 2 1.46 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262979 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262979&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118256794 376224797 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 498094 NS(=O)(=O)c1c(ccc(C2CCC3(CCNCC3)CC2)c1-c1nnn[nH]1)C(F)(F)F InChI=1S/C18H23F3N6O2S/c19-18(20,21)13-2-1-12(11-3-5-17(6-4-11)7-9-23-10-8-17)14(15(13)30(22,28)29)16-24-26-27-25-16/h1-2,11,23H,3-10H2,(H2,22,28,29)(H,24,25,26,27) BUAWNACQGXBPMY-UHFFFAOYSA-N 262980 3-(3-azaspiro[5.5]undecan-9-yl)-2-(1H-tetrazol-5-yl)-6-(trifluoromethyl)benzenesulfonamide::US9708336, 833 Metallo-beta-lactamase type 2 4.31 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262980 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262980&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118257391 376224798 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 498097 NC1(CN2CCC3(CCC(CC3)c3ccc(c(c3-c3nnn[nH]3)S(N)(=O)=O)C(F)(F)F)CC2)CC1 InChI=1S/C22H30F3N7O2S/c23-22(24,25)16-2-1-15(17(18(16)35(27,33)34)19-28-30-31-29-19)14-3-5-20(6-4-14)9-11-32(12-10-20)13-21(26)7-8-21/h1-2,14H,3-13,26H2,(H2,27,33,34)(H,28,29,30,31) AUIMVTPAELUUIV-UHFFFAOYSA-N 262981 3-[3-[(1-aminocyclopropyl)methyl]-3-azaspiro[5.5]undecan-9-yl]-2-(1H-tetrazol-5-yl)-6-(trifluoromethyl)benzenesulfonamide::US9708336, 834 Metallo-beta-lactamase type 2 5.45 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262981 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262981&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266392 376224799 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 498100 NS(=O)(=O)c1c(ccc(C2CCN(CC2)C2CCNCC2)c1-c1nnn[nH]1)C(F)(F)F InChI=1S/C18H24F3N7O2S/c19-18(20,21)14-2-1-13(15(16(14)31(22,29)30)17-24-26-27-25-17)11-5-9-28(10-6-11)12-3-7-23-8-4-12/h1-2,11-12,23H,3-10H2,(H2,22,29,30)(H,24,25,26,27) LLEYWBOYDDTTIZ-UHFFFAOYSA-N 262982 3-[1-(4-piperidyl)-4-piperidyl]-2-(1H-tetrazol-5-yl)-6-(trifluoromethyl)benzenesulfonamide::US9708336, 835 Metallo-beta-lactamase type 2 232 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262982 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262982&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118257318 376224800 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 498103 NC1Cc2cccc(c2C1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)C(F)(F)F 262983 3-(2-aminoindan-4-yl)-2-(1H-tetrazol-5-yl)-6-(trifluoromethyl)benzenesulfonamide::US9708336, 836 Metallo-beta-lactamase type 2 134 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262983 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262983&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118257193 376224801 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 498106 NC[C@H](N)C(=O)NC1CCC(CC1)c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)C(F)(F)F 262984 (S)-2,3-diamino-N-((1r,4S)-4-(3-sulfamoyl-2-(1H-tetrazol-5-yl)-4-(trifluoromethyl)phenyl)cyclohexyl)propanamide::US9708336, 837 Metallo-beta-lactamase type 2 21.2 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262984 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262984&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266391 376224802 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 498109 NC1CCC(CC1)c1ccc(CCC2CCNCC2)c(c1-c1nn[nH]n1)S(N)(=O)=O InChI=1S/C20H31N7O2S/c21-16-6-3-14(4-7-16)17-8-5-15(2-1-13-9-11-23-12-10-13)19(30(22,28)29)18(17)20-24-26-27-25-20/h5,8,13-14,16,23H,1-4,6-7,9-12,21H2,(H2,22,28,29)(H,24,25,26,27) NTAFOYBLJLMABZ-UHFFFAOYSA-N 262985 3-(4-aminocyclohexyl)-6-[2-(4-piperidyl)ethyl]-2-(2H-tetrazol-5-yl)benzenesulfonamide::US9708336, 838 Metallo-beta-lactamase type 2 1679 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262985 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262985&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118256795 376224803 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 498112 NC1CCC(CC1)c1ccc(CC2CCNCC2)c(c1-c1nn[nH]n1)S(N)(=O)=O InChI=1S/C19H29N7O2S/c20-15-4-1-13(2-5-15)16-6-3-14(11-12-7-9-22-10-8-12)18(29(21,27)28)17(16)19-23-25-26-24-19/h3,6,12-13,15,22H,1-2,4-5,7-11,20H2,(H2,21,27,28)(H,23,24,25,26) XYNWNMMVGCXZJK-UHFFFAOYSA-N 262986 3-(4-aminocyclohexyl)-6-(piperidin-4-ylmethyl)-2-(2H-tetrazol-5-yl)benzenesulfonamide::US9708336, 839 Metallo-beta-lactamase type 2 359 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262986 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262986&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118257322 376224804 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 498115 NS(=O)(=O)c1c(ccc(-c2cccn3nc[nH+]c23)c1-c1nnn[nH]1)C(F)(F)F InChI=1S/C14H9F3N8O2S/c15-14(16,17)9-4-3-7(8-2-1-5-25-13(8)19-6-20-25)10(11(9)28(18,26)27)12-21-23-24-22-12/h1-6H,(H2,18,26,27)(H,21,22,23,24)/p+1 AXMOMQCAKWIDBO-UHFFFAOYSA-O 262987 3-([1,2,4]triazolo[1,5-a]pyridin-8-yl)-2-(1H-tetrazol-5-yl)-6-(trifluoromethyl)benzenesulfonamide::US9708336, 840 Metallo-beta-lactamase type 2 14.1 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262987 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262987&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823788 376224805 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 495607 COc1ccc(Cn2nnnc2-c2c(Br)cccc2S(N)(=O)=O)cc1 InChI=1S/C15H14BrN5O3S/c1-24-11-7-5-10(6-8-11)9-21-15(18-19-20-21)14-12(16)3-2-4-13(14)25(17,22)23/h2-8H,9H2,1H3,(H2,17,22,23) KYNMIOMKQGFYOV-UHFFFAOYSA-N 262090 3-Bromo-2-(1-(4-methoxybenzyl)(1H-tetrazol-5-yl))benzenesulfonamide and 3-bromo-2-(2-(4-methoxybenzyl)(1H-tetrazol-5-yl))benzenesulfonamide::US9708336, 1 Metallo-beta-lactamase type 2 64.8 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262090 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262090&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118256805 376223927 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 495610 NS(=O)(=O)c1cccc(-c2ccc(cc2)C(=O)NC2CCOC2)c1-c1nn[nH]n1 262092 3'-sulfamoyl-N-(tetrahydrofuran-3- yl)-2'-(2H-tetrazol-5-yl)biphenyl- 4-carboxamide::US9708336, 2 Metallo-beta-lactamase type 2 262 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262092 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262092&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266163 376223929 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 495613 NS(=O)(=O)c1cccc(-c2ccc(cc2)C(O)C(F)(F)F)c1-c1nn[nH]n1 262152 2(2H-tetrazol-5-yl)4'-(2,2,2- trifluoro-1-hydroxyethyl)biphenyl- 3-sulfonamide::US9708336, 3 Metallo-beta-lactamase type 2 8.92 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262152 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262152&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266209 376223980 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 495616 CC(N1CCOCC1)c1ccc(cc1)-c1cccc(c1-c1nn[nH]n1)S(N)(=O)=O 262153 4'-(1-morpholin-4-ylethyl)-2-(2H- tetrazol-5-yl)biphenyl-3- sulfonamide::US9708336, 4 Metallo-beta-lactamase type 2 11.3 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262153 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262153&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266204 376223981 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 495619 Cc1nc2ccccc2n1Cc1ccc(cc1)B1OC(C)(C)C(C)(C)O1 InChI=1S/C21H25BN2O2/c1-15-23-18-8-6-7-9-19(18)24(15)14-16-10-12-17(13-11-16)22-25-20(2,3)21(4,5)26-22/h6-13H,14H2,1-5H3 YZEPCJMVEZJYEG-UHFFFAOYSA-N 262154 2-(2H-tetrazol-5-yl)-4'-(2H-1,2,3- triazol-2-yl)biphenyl-3- sulfonamide::US9708336, 5 Metallo-beta-lactamase type 2 72.3 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262154 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262154&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 123949802 376223982 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 495622 CC(C)(C)OC(=O)NCc1ccc(cn1)B1OC(C)(C)C(C)(C)O1 InChI=1S/C17H27BN2O4/c1-15(2,3)22-14(21)20-11-13-9-8-12(10-19-13)18-23-16(4,5)17(6,7)24-18/h8-10H,11H2,1-7H3,(H,20,21) CHYIKVATWKWDCS-UHFFFAOYSA-N 262155 4'-(2-hydroxy-1-methylethoxy)-2- (2H-tetrazol-5-yl)biphenyl-3- sulfonamide::US9708336, 6 Metallo-beta-lactamase type 2 39.6 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262155 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262155&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 101043307 376223983 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 495625 CC(C)(C)OC(=O)NCCc1ccc(cn1)B1OC(C)(C)C(C)(C)O1 InChI=1S/C18H29BN2O4/c1-16(2,3)23-15(22)20-11-10-14-9-8-13(12-21-14)19-24-17(4,5)18(6,7)25-19/h8-9,12H,10-11H2,1-7H3,(H,20,22) ABODNKKESQYAOH-UHFFFAOYSA-N 262156 US9708336, 7::tert-butyl 4-[3'-sulfamoyl-2'-(2H- tetrazol-5-yl)biphenyl-4- yl]piperazine-1-carboxylate Metallo-beta-lactamase type 2 29.4 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262156 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262156&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 123299559 376223984 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 495628 COc1ccc(cc1)-c1cccc(c1-c1nn[nH]n1)S(N)(=O)=O InChI=1S/C14H13N5O3S/c1-22-10-7-5-9(6-8-10)11-3-2-4-12(23(15,20)21)13(11)14-16-18-19-17-14/h2-8H,1H3,(H2,15,20,21)(H,16,17,18,19) VDVJPSIELWMKLI-UHFFFAOYSA-N 262157 4'-methoxy-2-(2H-tetrazol-5- yl)biphenyl-3-sulfonamide::US9708336, 8 Metallo-beta-lactamase type 2 78.2 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262157 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262157&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266216 376223985 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 495631 CCN(CC)C(=O)c1ccc(cc1)-c1cccc(c1-c1nn[nH]n1)S(N)(=O)=O InChI=1S/C18H20N6O3S/c1-3-24(4-2)18(25)13-10-8-12(9-11-13)14-6-5-7-15(28(19,26)27)16(14)17-20-22-23-21-17/h5-11H,3-4H2,1-2H3,(H2,19,26,27)(H,20,21,22,23) HRXUVVVAUSLRGJ-UHFFFAOYSA-N 262158 N,N-diethyl-3'-sulfamoyl-2'-(2H- tetrazol-5-yl)biphenyl-4- carboxamide::US9708336, 9 Metallo-beta-lactamase type 2 17.2 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262158 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262158&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266211 376223986 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 495634 NS(=O)(=O)c1cccc(-c2ccc(cc2)C(=O)N2CCOCC2)c1-c1nn[nH]n1 InChI=1S/C18H18N6O4S/c19-29(26,27)15-3-1-2-14(16(15)17-20-22-23-21-17)12-4-6-13(7-5-12)18(25)24-8-10-28-11-9-24/h1-7H,8-11H2,(H2,19,26,27)(H,20,21,22,23) HJNGNRXJRFNNBY-UHFFFAOYSA-N 262159 4'-(morpholin-4-ylcarbonyl)-2- (2H-tetrazol-5-yl)biphenyl-3- sulfonamide::US9708336, 10 Metallo-beta-lactamase type 2 62.6 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262159 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262159&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266207 376223987 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 495637 NS(=O)(=O)c1cccc(-c2ccc(cc2)C(=O)NC2CC2)c1-c1nn[nH]n1 InChI=1S/C17H16N6O3S/c18-27(25,26)14-3-1-2-13(15(14)16-20-22-23-21-16)10-4-6-11(7-5-10)17(24)19-12-8-9-12/h1-7,12H,8-9H2,(H,19,24)(H2,18,25,26)(H,20,21,22,23) FKLRUZDSWZRUBC-UHFFFAOYSA-N 262160 N-cyclopropyl-3'-sulfamoyl-2'- (2H-tetrazol-5-yl)biphenyl-4- carboxamide::US9708336, 11 Metallo-beta-lactamase type 2 109 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262160 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262160&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266208 376223988 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496618 NS(=O)(=O)c1cccc(-c2ccc(CN3CCOCC3)cc2)c1-c1nnn[nH]1 InChI=1S/C18H20N6O3S/c19-28(25,26)16-3-1-2-15(17(16)18-20-22-23-21-18)14-6-4-13(5-7-14)12-24-8-10-27-11-9-24/h1-7H,8-12H2,(H2,19,25,26)(H,20,21,22,23) KJKHNHKUVYLABS-UHFFFAOYSA-N 262489 4'-(morpholin-4-ylmethyl)-2- (1H-tetrazol-5-yl)biphenyl- 3-sulfonamide::US9708336, 341 Metallo-beta-lactamase type 2 22.1 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262489 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262489&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118265927 376224316 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496621 NS(=O)(=O)c1cccc(-c2ccc(CN3CNC(=O)C3)cc2)c1-c1nnn[nH]1 InChI=1S/C17H17N7O3S/c18-28(26,27)14-3-1-2-13(16(14)17-20-22-23-21-17)12-6-4-11(5-7-12)8-24-9-15(25)19-10-24/h1-7H,8-10H2,(H,19,25)(H2,18,26,27)(H,20,21,22,23) FHVKFIUVSHYZHZ-UHFFFAOYSA-N 262490 4'-[(4-oxoimidazolidin-1- yl)methyl]-2-(1H-tetrazol-5- yl)biphenyl-3-sulfonamide::US9708336, 342 Metallo-beta-lactamase type 2 46.0 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262490 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262490&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118265925 376224317 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496624 NS(=O)(=O)c1cccc(-c2ccc(CN3CCC(C3)C(O)=O)cc2)c1-c1nnn[nH]1 262491 1-{[3'-sulfamoyl-2'-(1H- tetrazol-5-yl)biphenyl-4- yl]methyl}pyrrolidine-3- carboxylic acid::US9708336, 343 Metallo-beta-lactamase type 2 373 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262491 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262491&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266608 376224318 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496627 CC(CC(O)=O)NCc1ccc(cc1)-c1cccc(c1-c1nnn[nH]1)S(N)(=O)=O 262492 3-({[3'-sulfamoyl-2'-(1H- tetrazol-5-yl)biphenyl-4- yl]methyl}amino)butanoic acid::US9708336, 344 Metallo-beta-lactamase type 2 242 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262492 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262492&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266609 376224319 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496630 CC[C@H](CO)NCc1ccc(cc1)-c1cccc(c1-c1nnn[nH]1)S(N)(=O)=O 262493 4'-({[(1S)-1- (hydroxymethyl)propyl]amino} methyl)-2-(1H-tetrazol-5- yl)biphenyl-3-sulfonamide::US9708336, 345 Metallo-beta-lactamase type 2 213 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262493 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262493&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266610 376224320 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496633 CC1(C)CCN(Cc2ccc(cc2)-c2cccc(c2-c2nnn[nH]2)S(N)(=O)=O)C1 InChI=1S/C20H24N6O2S/c1-20(2)10-11-26(13-20)12-14-6-8-15(9-7-14)16-4-3-5-17(29(21,27)28)18(16)19-22-24-25-23-19/h3-9H,10-13H2,1-2H3,(H2,21,27,28)(H,22,23,24,25) RUXQAQVFYJBNHZ-UHFFFAOYSA-N 262494 4'-[(3,3-dimethylpyrrolidin- 1-yl)methyl]-2-(1H-tetrazol- 5-yl)biphenyl-3-sulfonamide::US9708336, 346 Metallo-beta-lactamase type 2 232 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262494 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262494&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266611 376224321 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496636 CN(C)[C@@H]1CCN(Cc2ccc(cc2)-c2cccc(c2-c2nnn[nH]2)S(N)(=O)=O)C1 262495 4'-{[(3R)-3- (dimethylamino)pyrrolidin- 1-yl]methyl}-2-(1H-tetrazol- 5-yl)biphenyl-3-sulfonamide::US9708336, 347 Metallo-beta-lactamase type 2 185 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262495 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262495&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 122687716 376224322 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496639 CN(C)CCCNCc1ccc(cc1)-c1cccc(c1-c1nnn[nH]1)S(N)(=O)=O InChI=1S/C19H25N7O2S/c1-26(2)12-4-11-21-13-14-7-9-15(10-8-14)16-5-3-6-17(29(20,27)28)18(16)19-22-24-25-23-19/h3,5-10,21H,4,11-13H2,1-2H3,(H2,20,27,28)(H,22,23,24,25) WWIFWEDTLRNYBU-UHFFFAOYSA-N 262496 4'-({[3- (dimethylamino)propyl]amino} methyl)-2-(1H-tetrazol-5- yl)biphenyl-3-sulfonamide::US9708336, 348 Metallo-beta-lactamase type 2 1330 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262496 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262496&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266603 376224323 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496642 CN1CCC(NCc2ccc(cc2)-c2cccc(c2-c2nnn[nH]2)S(N)(=O)=O)C1=O 262497 4'-{[(1-methyl-2- oxopyrrolidin-3- yl)amino]methyl}-2-(1H- tetrazol-5-yl)biphenyl-3- sulfonamide::US9708336, 349 Metallo-beta-lactamase type 2 61.1 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262497 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262497&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266225 376224324 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496645 NS(=O)(=O)c1cccc(-c2ccc(CNCCn3ccnn3)cc2)c1-c1nnn[nH]1 InChI=1S/C18H19N9O2S/c19-30(28,29)16-3-1-2-15(17(16)18-22-24-25-23-18)14-6-4-13(5-7-14)12-20-8-10-27-11-9-21-26-27/h1-7,9,11,20H,8,10,12H2,(H2,19,28,29)(H,22,23,24,25) NIADDEILRHEVLW-UHFFFAOYSA-N 262498 2-(1H-tetrazol-5-yl)-4'-({[2- (1H-1,2,3-triazol-1- yl)ethyl]amino}methyl) biphenyl-3-sulfonamide::US9708336, 350 Metallo-beta-lactamase type 2 39.7 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262498 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262498&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823598 376224325 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496648 CC(O)C1CCN(Cc2ccc(cc2)-c2cccc(c2-c2nnn[nH]2)S(N)(=O)=O)C1 262499 4'-{[3-(1- hydroxyethyl)pyrrolidin-1- yl]methyl}-2-(1H-tetrazol-5- yl)biphenyl-3-sulfonamide::US9708336, 351 Metallo-beta-lactamase type 2 332 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262499 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262499&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266228 376224326 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496651 CCN1CCC(CC1)NCc1ccc(cc1)-c1cccc(c1-c1nnn[nH]1)S(N)(=O)=O InChI=1S/C21H27N7O2S/c1-2-28-12-10-17(11-13-28)23-14-15-6-8-16(9-7-15)18-4-3-5-19(31(22,29)30)20(18)21-24-26-27-25-21/h3-9,17,23H,2,10-14H2,1H3,(H2,22,29,30)(H,24,25,26,27) DGDZMRZFJPILRT-UHFFFAOYSA-N 262500 4'-{[(1-ethylpiperidin-4- yl)amino]methyl}-2-(1H- tetrazol-5-yl)biphenyl-3- sulfonamide::US9708336, 352 Metallo-beta-lactamase type 2 547 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262500 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262500&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266226 376224327 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496654 CC(NCc1ccc(cc1)-c1cccc(c1-c1nnn[nH]1)S(N)(=O)=O)c1nn[nH]n1 262501 2-(1H-tetrazol-5-yl)-4'-({[1- (2H-tetrazol-5- yl)ethyl]amino}methyl) biphenyl-3-sulfonamide::US9708336, 353 Metallo-beta-lactamase type 2 28.0 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262501 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262501&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266223 376224328 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496657 Cc1cc(CNCc2ccc(cc2)-c2cccc(c2-c2nnn[nH]2)S(N)(=O)=O)n[nH]1 InChI=1S/C19H20N8O2S/c1-12-9-15(23-22-12)11-21-10-13-5-7-14(8-6-13)16-3-2-4-17(30(20,28)29)18(16)19-24-26-27-25-19/h2-9,21H,10-11H2,1H3,(H,22,23)(H2,20,28,29)(H,24,25,26,27) UHVUFHNTBFBGQQ-UHFFFAOYSA-N 262502 4'-({[(5-methyl-1H-pyrazol- 3-yl)methyl]amino}methyl)- 2-(1H-tetrazol-5- yl)biphenyl-3-sulfonamide::US9708336, 354 Metallo-beta-lactamase type 2 16.4 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262502 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262502&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266349 376224329 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496660 CN(C)C1CCC(CC1)NCc1ccc(cc1)-c1cccc(c1-c1nnn[nH]1)S(N)(=O)=O InChI=1S/C22H29N7O2S/c1-29(2)18-12-10-17(11-13-18)24-14-15-6-8-16(9-7-15)19-4-3-5-20(32(23,30)31)21(19)22-25-27-28-26-22/h3-9,17-18,24H,10-14H2,1-2H3,(H2,23,30,31)(H,25,26,27,28) FQYBFGPDVZDXOP-UHFFFAOYSA-N 262503 4'-({[4- (dimethylamino)cyclohexyl] amino}methyl)-2-(1H- tetrazol-5-yl)biphenyl-3- sulfonamide::US9708336, 355 Metallo-beta-lactamase type 2 467 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262503 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262503&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266346 376224330 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496663 CN(C)CCCCNCc1ccc(cc1)-c1cccc(c1-c1nnn[nH]1)S(N)(=O)=O InChI=1S/C20H27N7O2S/c1-27(2)13-4-3-12-22-14-15-8-10-16(11-9-15)17-6-5-7-18(30(21,28)29)19(17)20-23-25-26-24-20/h5-11,22H,3-4,12-14H2,1-2H3,(H2,21,28,29)(H,23,24,25,26) HHJOCJGKGYXYSW-UHFFFAOYSA-N 262504 4'-({[4- (dimethylamino)butyl]amino} methyl)-2-(1H-tetrazol-5- yl)biphenyl-3-sulfonamide::US9708336, 356 Metallo-beta-lactamase type 2 1536 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262504 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262504&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266374 376224331 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496666 C[C@@H](O)[C@H](NCc1ccc(cc1)-c1cccc(c1-c1nnn[nH]1)S(N)(=O)=O)C(O)=O 262505 N-{[3'-sulfamoyl-2'-(1H- tetrazol-5-yl)biphenyl-4- yl]methyl}-L-threonine::US9708336, 357 Metallo-beta-lactamase type 2 182 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262505 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262505&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266332 376224332 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496669 CC(NCc1ccc(cc1)-c1cccc(c1-c1nnn[nH]1)S(N)(=O)=O)C(O)=O 262506 N-{[3'-sulfamoyl-2'-(1H- tetrazol-5-yl)biphenyl-4- yl]methyl}alanine::US9708336, 358 Metallo-beta-lactamase type 2 288 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262506 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262506&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266333 376224333 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496672 CNCC(C)NCc1ccc(cc1)-c1cccc(c1-c1nn[nH]n1)S(N)(=O)=O 262507 4'-({[1-methyl-2- (methylamino)ethyl]amino} methyl)-2-(2H-tetrazol-5- yl)biphenyl-3-sulfonamide::US9708336, 359 Metallo-beta-lactamase type 2 104 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262507 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262507&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266463 376224334 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496675 Cc1nc(CNCc2ccc(cc2)-c2cccc(c2-c2nnn[nH]2)S(N)(=O)=O)no1 InChI=1S/C18H18N8O3S/c1-11-21-16(24-29-11)10-20-9-12-5-7-13(8-6-12)14-3-2-4-15(30(19,27)28)17(14)18-22-25-26-23-18/h2-8,20H,9-10H2,1H3,(H2,19,27,28)(H,22,23,25,26) OXRPXSQTDRABJC-UHFFFAOYSA-N 262508 4'-({[(5-methyl-1,2,4- oxadiazol-3- yl)methyl]amino}methyl)-2- (1H-tetrazol-5-yl)biphenyl- 3-sulfonamide::US9708336, 360 Metallo-beta-lactamase type 2 37.6 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262508 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262508&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266347 376224335 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496678 CN(CCC(O)=O)Cc1ccc(cc1)-c1cccc(c1-c1nnn[nH]1)S(N)(=O)=O InChI=1S/C18H20N6O4S/c1-24(10-9-16(25)26)11-12-5-7-13(8-6-12)14-3-2-4-15(29(19,27)28)17(14)18-20-22-23-21-18/h2-8H,9-11H2,1H3,(H,25,26)(H2,19,27,28)(H,20,21,22,23) QNGGZZXLXLDATM-UHFFFAOYSA-N 262509 N-methyl-N-{[3'-sulfamoyl- 2'-(1H-tetrazol-5- yl)biphenyl-4-yl]methyl}- beta-alanine::US9708336, 361 Metallo-beta-lactamase type 2 139 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262509 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262509&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266327 376224336 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496681 NC(=O)C1CN(Cc2ccc(cc2)-c2cccc(c2-c2nnn[nH]2)S(N)(=O)=O)C1 InChI=1S/C18H19N7O3S/c19-17(26)13-9-25(10-13)8-11-4-6-12(7-5-11)14-2-1-3-15(29(20,27)28)16(14)18-21-23-24-22-18/h1-7,13H,8-10H2,(H2,19,26)(H2,20,27,28)(H,21,22,23,24) CTMYSCDGFCLULG-UHFFFAOYSA-N 262510 1-{[3'-sulfamoyl-2'-(1H- tetrazol-5-yl)biphenyl-4- yl]methyl}azetidine-3- carboxamide::US9708336, 362 Metallo-beta-lactamase type 2 116 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262510 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262510&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266341 376224337 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 495640 NS(=O)(=O)c1cccc(-c2ccc(cc2)N2CCOCC2)c1-c1nn[nH]n1 InChI=1S/C17H18N6O3S/c18-27(24,25)15-3-1-2-14(16(15)17-19-21-22-20-17)12-4-6-13(7-5-12)23-8-10-26-11-9-23/h1-7H,8-11H2,(H2,18,24,25)(H,19,20,21,22) JPAKOGOEEMVVEC-UHFFFAOYSA-N 262161 4'-(morpholin-4-yl-2-(2H-tetrazol- 5-yl)biphenyl-3-sulfonamide::US9708336, 12 Metallo-beta-lactamase type 2 41.8 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262161 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262161&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266212 376223989 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 495643 CNC(=O)c1ccc(cc1)-c1cccc(c1-c1nn[nH]n1)S(N)(=O)=O InChI=1S/C15H14N6O3S/c1-17-15(22)10-7-5-9(6-8-10)11-3-2-4-12(25(16,23)24)13(11)14-18-20-21-19-14/h2-8H,1H3,(H,17,22)(H2,16,23,24)(H,18,19,20,21) RMKSHPHDAAKKDR-UHFFFAOYSA-N 262162 N-methyl-3'-sulfamoyl-2'-(2H- tetrazol-5-yl)biphenyl-4- carboxamide::US9708336, 13 Metallo-beta-lactamase type 2 173 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262162 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262162&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266217 376223990 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 495646 NS(=O)(=O)c1cccc(-c2ccccc2)c1-c1nn[nH]n1 InChI=1S/C13H11N5O2S/c14-21(19,20)11-8-4-7-10(9-5-2-1-3-6-9)12(11)13-15-17-18-16-13/h1-8H,(H2,14,19,20)(H,15,16,17,18) CIQMSJCCNJVMJZ-UHFFFAOYSA-N 262164 2-(2H-tetrazol-5-yl)biphenyl-3- sulfonamide::US9708336, 14 Metallo-beta-lactamase type 2 172 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262164 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262164&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118257022 376223992 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 495649 NC(=O)c1ccc(cc1)-c1cccc(c1-c1nn[nH]n1)S(N)(=O)=O InChI=1S/C14H12N6O3S/c15-13(21)9-6-4-8(5-7-9)10-2-1-3-11(24(16,22)23)12(10)14-17-19-20-18-14/h1-7H,(H2,15,21)(H2,16,22,23)(H,17,18,19,20) QKQSMEZWDKRIFV-UHFFFAOYSA-N 262165 3'-sulfamoyl-2'-(2H-tetrazol-5- yl)biphenyl-4-carboxamide::US9708336, 15 Metallo-beta-lactamase type 2 134 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262165 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262165&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266213 376223993 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 495652 CS(=O)(=O)c1ccc(cc1)-c1cccc(c1-c1nn[nH]n1)S(N)(=O)=O InChI=1S/C14H13N5O4S2/c1-24(20,21)10-7-5-9(6-8-10)11-3-2-4-12(25(15,22)23)13(11)14-16-18-19-17-14/h2-8H,1H3,(H2,15,22,23)(H,16,17,18,19) JAKXBXAXDXTTLP-UHFFFAOYSA-N 262167 4'-(methylsulfonyl)-2-(2H- tetrazol-5-yl)biphenyl-3- sulfonamide::US9708336, 16 Metallo-beta-lactamase type 2 85.5 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262167 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262167&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266214 376223995 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 495655 NS(=O)(=O)c1cccc(-c2ccc(cc2)C(=O)NCCO)c1-c1nn[nH]n1 InChI=1S/C16H16N6O4S/c17-27(25,26)13-3-1-2-12(14(13)15-19-21-22-20-15)10-4-6-11(7-5-10)16(24)18-8-9-23/h1-7,23H,8-9H2,(H,18,24)(H2,17,25,26)(H,19,20,21,22) JBSCQYQWGFMDFN-UHFFFAOYSA-N 262168 N-(2-hydroxyethyl)-3'-sulfamoyl- 2'-(2H-tetrazol-5-yl)biphenyl-4- carboxamide::US9708336, 17 Metallo-beta-lactamase type 2 87.5 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262168 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262168&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266219 376223996 C04080 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 495658 NS(=O)(=O)c1cccc(-c2ccc(cc2)N2CCCCC2)c1-c1nn[nH]n1 InChI=1S/C18H20N6O2S/c19-27(25,26)16-6-4-5-15(17(16)18-20-22-23-21-18)13-7-9-14(10-8-13)24-11-2-1-3-12-24/h4-10H,1-3,11-12H2,(H2,19,25,26)(H,20,21,22,23) XDKZUSXDOYGNPS-UHFFFAOYSA-N 262169 4'-piperidin-1-yl-2-(2H-tetrazol-5- yl)biphenyl-3-sulfonamide::US9708336, 18 Metallo-beta-lactamase type 2 23.4 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262169 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262169&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266215 376223997 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 495661 NS(=O)(=O)c1cccc(-c2cccnc2)c1-c1nn[nH]n1 InChI=1S/C12H10N6O2S/c13-21(19,20)10-5-1-4-9(8-3-2-6-14-7-8)11(10)12-15-17-18-16-12/h1-7H,(H2,13,19,20)(H,15,16,17,18) ZFKNEOQKUNISTF-UHFFFAOYSA-N 262170 3-pyridin-3-yl-2-(2H-tetrazol-5- yl)benzenesulfonamide::US9708336, 19 Metallo-beta-lactamase type 2 1778 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262170 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262170&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266627 376223998 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 495664 NS(=O)(=O)c1cccc(-c2cccs2)c1-c1nn[nH]n1 InChI=1S/C11H9N5O2S2/c12-20(17,18)9-5-1-3-7(8-4-2-6-19-8)10(9)11-13-15-16-14-11/h1-6H,(H2,12,17,18)(H,13,14,15,16) JIBREXIELYDJDM-UHFFFAOYSA-N 262171 2-(2H-tetrazol-5-yl)-3-thiophen- 2-ylbenzenesulfonamide::US9708336, 20 Metallo-beta-lactamase type 2 331 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262171 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262171&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266629 376223999 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 495667 NS(=O)(=O)c1cccc(-c2cnc(s2)C2(O)CCC2)c1-c1nn[nH]n1 InChI=1S/C14H14N6O3S2/c15-25(22,23)10-4-1-3-8(11(10)12-17-19-20-18-12)9-7-16-13(24-9)14(21)5-2-6-14/h1,3-4,7,21H,2,5-6H2,(H2,15,22,23)(H,17,18,19,20) GDNZNBWQELZCSF-UHFFFAOYSA-N 262172 3-[2-(1-hydroxycyclobutyl)-1,3- thiazol-5-yl]-2-(2H-tetrazol-5- yl)benzenesulfonamide::US9708336, 21 Metallo-beta-lactamase type 2 2273 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262172 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262172&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266625 376224000 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 495670 NS(=O)(=O)c1cccc(-c2ccc(nc2)C2(OCCO2)C(F)(F)F)c1-c1nn[nH]n1 InChI=1S/C16H13F3N6O4S/c17-16(18,19)15(28-6-7-29-15)12-5-4-9(8-21-12)10-2-1-3-11(30(20,26)27)13(10)14-22-24-25-23-14/h1-5,8H,6-7H2,(H2,20,26,27)(H,22,23,24,25) GOORYTBQYFAOQA-UHFFFAOYSA-N 262173 2-(2H-tetrazol-5-yl)-3-{6-[2- (trifluoromethyl)-1,3-dioxolan- 2-yl]pyridin-3- yl}benzenesulfonamide::US9708336, 22 Metallo-beta-lactamase type 2 31.8 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262173 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262173&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266628 376224001 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 495673 C[C@H]1NC(=O)O[C@H]1c1ccc(cc1)-c1cccc(c1-c1nnn[nH]1)S(N)(=O)=O 262174 4'-[(4R,5S)-4-methyl-2-oxo-1,3- oxazolidin-5-yl]-2-(1H-tetrazol- 5-yl)biphenyl-3-sulfonamide::US9708336, 23 Metallo-beta-lactamase type 2 4.36 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262174 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262174&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266626 376224002 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 495676 NS(=O)(=O)c1cccc(-c2ccc(cc2)C(O)C(F)F)c1-c1nnn[nH]1 262175 4'-(2,2-difluoro-1-hydroxyethyl)- 2-(1H-tetrazol-5-yl)biphenyl-3- sulfonamide::US9708336, 24 Metallo-beta-lactamase type 2 17.8 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262175 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262175&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266630 376224003 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 495679 NS(=O)(=O)c1cccc(-c2ccc(cc2)C2(CCOCC2)C#N)c1-c1nnn[nH]1 InChI=1S/C19H18N6O3S/c20-12-19(8-10-28-11-9-19)14-6-4-13(5-7-14)15-2-1-3-16(29(21,26)27)17(15)18-22-24-25-23-18/h1-7H,8-11H2,(H2,21,26,27)(H,22,23,24,25) AYWBFIREHRSZBF-UHFFFAOYSA-N 262176 4'-(4-cyanotetrahydro-2H-pyran- 4-yl)-2-(1H-tetrazol-5- yl)biphenyl-3-sulfonamide::US9708336, 25 Metallo-beta-lactamase type 2 3.60 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262176 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262176&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266631 376224004 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 495682 NS(=O)(=O)c1cccc(-c2ccc(CO)cc2)c1-c1nnn[nH]1 InChI=1S/C14H13N5O3S/c15-23(21,22)12-3-1-2-11(13(12)14-16-18-19-17-14)10-6-4-9(8-20)5-7-10/h1-7,20H,8H2,(H2,15,21,22)(H,16,17,18,19) NVAPOOJIRBPVGS-UHFFFAOYSA-N 262177 4'-(hydroxymethyl)-2-(1H- tetrazol-5-yl)biphenyl-3- sulfonamide::US9708336, 26 Metallo-beta-lactamase type 2 46.2 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262177 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262177&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118265878 376224005 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 495685 NS(=O)(=O)c1cccc(-c2ccc(cc2)C2CCNC2=O)c1-c1nnn[nH]1 262178 4'-(2-oxopyrrolidin-3-yl)-2-(1H- tetrazol-5-yl)biphenyl-3- sulfonamide::US9708336, 27 Metallo-beta-lactamase type 2 13.1 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262178 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262178&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118265877 376224006 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 495688 COC(=O)N1CCC(CC1)c1ccc(cc1)-c1cccc(c1-c1nnn[nH]1)S(N)(=O)=O InChI=1S/C20H22N6O4S/c1-30-20(27)26-11-9-14(10-12-26)13-5-7-15(8-6-13)16-3-2-4-17(31(21,28)29)18(16)19-22-24-25-23-19/h2-8,14H,9-12H2,1H3,(H2,21,28,29)(H,22,23,24,25) BNCLHYQXSLWKHR-UHFFFAOYSA-N 262179 US9708336, 28::methyl 4-[3'-sulfamoyl-2'-(1H- tetrazol-5-yl)biphenyl-4- yl]piperidine-1-carboxylate Metallo-beta-lactamase type 2 3.74 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262179 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262179&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118265879 376224007 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 495691 C[C@@H]1NC(=O)O[C@H]1c1ccc(cc1)-c1cccc(c1-c1nnn[nH]1)S(N)(=O)=O 262180 4'-[(4S,5S)-4-methyl-2-oxo-1,3- oxazolidin-5-yl]-2-(1H-tetrazol- 5-yl)biphenyl-3-sulfonamide::US9708336, 29 Metallo-beta-lactamase type 2 12.1 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262180 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262180&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118265880 376224008 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 495694 CN(C)CCCOc1ccc(cn1)-c1cccc(c1-c1nn[nH]n1)S(N)(=O)=O InChI=1S/C17H21N7O3S/c1-24(2)9-4-10-27-15-8-7-12(11-19-15)13-5-3-6-14(28(18,25)26)16(13)17-20-22-23-21-17/h3,5-8,11H,4,9-10H2,1-2H3,(H2,18,25,26)(H,20,21,22,23) XRBIKZQZSSDDSN-UHFFFAOYSA-N 262181 3-(6-(3- (dimethylamino)propoxy)pyridin- 3-yl)-2-(2H-tetrazol-5- yl)benzenesulfonamide::US9708336, 30 Metallo-beta-lactamase type 2 1668 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262181 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262181&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118265876 376224009 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 495697 NS(=O)(=O)c1cccc(-c2ccc(cc2)C2CCNCC2)c1-c1nn[nH]n1 InChI=1S/C18H20N6O2S/c19-27(25,26)16-3-1-2-15(17(16)18-21-23-24-22-18)14-6-4-12(5-7-14)13-8-10-20-11-9-13/h1-7,13,20H,8-11H2,(H2,19,25,26)(H,21,22,23,24) JLWPVVFPXXZFHC-UHFFFAOYSA-N 262182 4′-piperidin-4-yl-2-(1H-tetrazol-5-yl)biphenyl-3-sulfonamide, hydrochloride salt::US9708336, 31 Metallo-beta-lactamase type 2 34.4 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262182 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262182&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118256901 376224010 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 495700 COc1ccc(CN(Cc2ccc(OC)cc2)S(=O)(=O)c2c(Br)ccc(-c3ccc(cc3)C3CN(C3)C(=O)OC(C)(C)C)c2-c2nnn(Cc3ccc(OC)cc3)n2)cc1 InChI=1S/C45H47BrN6O7S/c1-45(2,3)59-44(53)50-28-35(29-50)33-13-15-34(16-14-33)39-23-24-40(46)42(41(39)43-47-49-52(48-43)27-32-11-21-38(58-6)22-12-32)60(54,55)51(25-30-7-17-36(56-4)18-8-30)26-31-9-19-37(57-5)20-10-31/h7-24,35H,25-29H2,1-6H3 ZUSRUYUZEYNCRR-UHFFFAOYSA-N 262183 US9708336, 32::tert-butyl 3-(3′-(N,N-bis(4-methoxybenzyl)sulfamoyl)-4′-bromo-2′-(2-(4-methoxybenzyl)-2H-tetrazol-5-yl)biphenyl-4-yl)azetidine-1-carboxylate Metallo-beta-lactamase type 2 18.1 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262183 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262183&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118257245 376224011 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 495703 CC(C)(C)OC(=O)NC[C@H]1CC[C@H](CI)CC1 InChI=1S/C13H24INO2/c1-13(2,3)17-12(16)15-9-11-6-4-10(8-14)5-7-11/h10-11H,4-9H2,1-3H3,(H,15,16)/t10-,11- FLAQQESCYCGJGK-XYPYZODXSA-N 262184 US9708336, 33::tert-butyl ((1r,4r)-4-(iodomethyl)cyclohexyl)methylcarbamate Metallo-beta-lactamase type 2 70.6 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262184 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262184&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 22106762 376224012 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496684 Cn1cncc1C[C@@H](NCc1ccc(cc1)-c1cccc(c1-c1nnn[nH]1)S(N)(=O)=O)C(O)=O 262511 3-methyl-N-{[3'-sulfamoyl- 2'-(1H-tetrazol-5- yl)biphenyl-4-yl]methyl}-D- histidine::US9708336, 363 Metallo-beta-lactamase type 2 233 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262511 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262511&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266465 376224338 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496687 CN(CC(O)=O)Cc1ccc(cc1)-c1cccc(c1-c1nnn[nH]1)S(N)(=O)=O InChI=1S/C17H18N6O4S/c1-23(10-15(24)25)9-11-5-7-12(8-6-11)13-3-2-4-14(28(18,26)27)16(13)17-19-21-22-20-17/h2-8H,9-10H2,1H3,(H,24,25)(H2,18,26,27)(H,19,20,21,22) QUMBBXOBPIFTKQ-UHFFFAOYSA-N 262512 N-methyl-N-{[3'-sulfamoyl- 2'-(1H-tetrazol-5- yl)biphenyl-4- yl]methyl}glycine::US9708336, 364 Metallo-beta-lactamase type 2 100 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262512 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262512&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266555 376224339 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496690 NS(=O)(=O)c1cccc(-c2ccc(CN[C@H]3COC[C@@H]3O)cc2)c1-c1nnn[nH]1 262513 4'-({[(3S,4R)-4- hydroxytetrahydrofuran-3- yl]amino}methyl)-2-(1H- tetrazol-5-yl)biphenyl-3- sulfonamide::US9708336, 365 Metallo-beta-lactamase type 2 52.1 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262513 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262513&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266551 376224340 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496693 CN1[C@H]2CC[C@@H]1CC(C2)NCc1ccc(cc1)-c1cccc(c1-c1nnn[nH]1)S(N)(=O)=O 262514 4'-({[(3-endo)-8-methyl-8- azabicyclo[3.2.1]oct-3- yl]amino}methyl)-2-(1H- tetrazol-5-yl)biphenyl-3- sulfonamide::US9708336, 366 Metallo-beta-lactamase type 2 257 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262514 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262514&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 122688019 376224341 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496696 CC(N(C)Cc1ccc(cc1)-c1cccc(c1-c1nnn[nH]1)S(N)(=O)=O)C(O)=O 262515 N-methyl-N-{[3'-sulfamoyl- 2'-(1H-tetrazol-5- yl)biphenyl-4- yl]methyl}alanine::US9708336, 367 Metallo-beta-lactamase type 2 60.3 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262515 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262515&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266556 376224342 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496699 CN(C)CCCN(C)Cc1ccc(cc1)-c1cccc(c1-c1nnn[nH]1)S(N)(=O)=O InChI=1S/C20H27N7O2S/c1-26(2)12-5-13-27(3)14-15-8-10-16(11-9-15)17-6-4-7-18(30(21,28)29)19(17)20-22-24-25-23-20/h4,6-11H,5,12-14H2,1-3H3,(H2,21,28,29)(H,22,23,24,25) JPVOCWRAVHSRPL-UHFFFAOYSA-N 262516 4'-({[3- (dimethylamino)propyl] (methyl)amino}methyl)-2-(1H- tetrazol-5-yl)biphenyl-3- sulfonamide::US9708336, 368 Metallo-beta-lactamase type 2 417 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262516 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262516&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266552 376224343 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496702 NS(=O)(=O)c1cccc(-c2ccc(CN[C@@H]3CC[C@H](O)C3)cc2)c1-c1nnn[nH]1 262517 4'-({[(1R,3S)-3- hydroxycyclopentyl]amino} methyl)-2-(1H-tetrazol-5- yl)biphenyl-3-sulfonamide::US9708336, 369 Metallo-beta-lactamase type 2 728 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262517 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262517&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266238 376224344 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496705 CN1C2CCC1CC(C2)NCc1ccc(cc1)-c1cccc(c1-c1nnn[nH]1)S(N)(=O)=O 262518 4'-{[(8-methyl-8- azabicyclo[3.2.1]oct-3- yl)amino]methyl}-2-(1H- tetrazol-5-yl)biphenyl-3- sulfonamide::US9708336, 370 Metallo-beta-lactamase type 2 45.8 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262518 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262518&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266237 376224345 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496708 CNC(=O)CNCc1ccc(cc1)-c1cccc(c1-c1nnn[nH]1)S(N)(=O)=O InChI=1S/C17H19N7O3S/c1-19-15(25)10-20-9-11-5-7-12(8-6-11)13-3-2-4-14(28(18,26)27)16(13)17-21-23-24-22-17/h2-8,20H,9-10H2,1H3,(H,19,25)(H2,18,26,27)(H,21,22,23,24) YFTCXAKYDCGNJW-UHFFFAOYSA-N 262519 N-methyl-N~2~-{[3'- sulfamoyl-2'-(1H-tetrazol-5- yl)biphenyl-4- yl]methyl}glycinamide::US9708336, 371 Metallo-beta-lactamase type 2 78.3 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262519 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262519&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266235 376224346 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496711 NS(=O)(=O)c1cccc(-c2ccc(CN3CC(F)(F)C3)cc2)c1-c1nnn[nH]1 InChI=1S/C17H16F2N6O2S/c18-17(19)9-25(10-17)8-11-4-6-12(7-5-11)13-2-1-3-14(28(20,26)27)15(13)16-21-23-24-22-16/h1-7H,8-10H2,(H2,20,26,27)(H,21,22,23,24) SMOUYEAIPKLZPT-UHFFFAOYSA-N 262520 4'-[(3,3-difluoroazetidin-1- yl)methyl]-2-(1H-tetrazol-5- yl)biphenyl-3-sulfonamide::US9708336, 372 Metallo-beta-lactamase type 2 15.7 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262520 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262520&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266236 376224347 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496714 NS(=O)(=O)c1cccc(-c2ccc(CNC[C@@]3(O)CCOC3)cc2)c1-c1nnn[nH]1 262521 4'-[({[(3S)-3- hydroxytetrahydrofuran-3- yl]methyl}amino)methyl]-2- (1H-tetrazol-5-yl)biphenyl- 3-sulfonamide::US9708336, 373 Metallo-beta-lactamase type 2 247 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262521 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262521&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266240 376224348 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496717 NS(=O)(=O)c1cccc(-c2ccc(CNC(CO)CO)cc2)c1-c1nnn[nH]1 InChI=1S/C17H20N6O4S/c18-28(26,27)15-3-1-2-14(16(15)17-20-22-23-21-17)12-6-4-11(5-7-12)8-19-13(9-24)10-25/h1-7,13,19,24-25H,8-10H2,(H2,18,26,27)(H,20,21,22,23) WTXCTXIIQZYSKI-UHFFFAOYSA-N 262522 4'-({[2-hydroxy-1- (hydroxymethyl)ethyl]amino} methyl)-2-(1H-tetrazol-5- yl)biphenyl-3-sulfonamide::US9708336, 374 Metallo-beta-lactamase type 2 264 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262522 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262522&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266243 376224349 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496720 NS(=O)(=O)c1cccc(-c2ccc(CNC3CCC(=O)NC3)cc2)c1-c1nnn[nH]1 262523 4'-{[(6-oxopiperidin-3- yl)amino]methyl}-2-(1H- tetrazol-5-yl)biphenyl-3- sulfonamide::US9708336, 375 Metallo-beta-lactamase type 2 97.6 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262523 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262523&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266241 376224350 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496723 NS(=O)(=O)c1cccc(-c2ccc(CNCC3(O)CCC3)cc2)c1-c1nnn[nH]1 InChI=1S/C19H22N6O3S/c20-29(27,28)16-4-1-3-15(17(16)18-22-24-25-23-18)14-7-5-13(6-8-14)11-21-12-19(26)9-2-10-19/h1,3-8,21,26H,2,9-12H2,(H2,20,27,28)(H,22,23,24,25) QNYDWSOVAGFNJB-UHFFFAOYSA-N 262524 4'-({[(1- hydroxycyclobutyl)methyl] amino}methyl)-2-(1H- tetrazol-5-yl)biphenyl-3- sulfonamide::US9708336, 376 Metallo-beta-lactamase type 2 96.6 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262524 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262524&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266244 376224351 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496726 NS(=O)(=O)c1cccc(-c2ccc(CNCc3ccncn3)cc2)c1-c1nnn[nH]1 InChI=1S/C19H18N8O2S/c20-30(28,29)17-3-1-2-16(18(17)19-24-26-27-25-19)14-6-4-13(5-7-14)10-22-11-15-8-9-21-12-23-15/h1-9,12,22H,10-11H2,(H2,20,28,29)(H,24,25,26,27) UPBKAWARKAAHGQ-UHFFFAOYSA-N 262525 4'-{[(pyrimidin-4- ylmethyl)amino]methyl}-2- (1H-tetrazol-5-yl)biphenyl- 3-sulfonamide::US9708336, 377 Metallo-beta-lactamase type 2 73.7 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262525 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262525&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823599 376224352 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496729 NS(=O)(=O)c1cccc(-c2ccc(CN3CCC3C(O)=O)cc2)c1-c1nnn[nH]1 262526 1-{[3'-sulfamoyl-2'-(1H- tetrazol-5-yl)biphenyl-4- yl]methyl}azetidine-2- carboxylic acid::US9708336, 378 Metallo-beta-lactamase type 2 262 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262526 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262526&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266276 376224353 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496732 NS(=O)(=O)c1cccc(-c2ccc(CNC3CCN(CC3)C3CCCC3)cc2)c1-c1nnn[nH]1 InChI=1S/C24H31N7O2S/c25-34(32,33)22-7-3-6-21(23(22)24-27-29-30-28-24)18-10-8-17(9-11-18)16-26-19-12-14-31(15-13-19)20-4-1-2-5-20/h3,6-11,19-20,26H,1-2,4-5,12-16H2,(H2,25,32,33)(H,27,28,29,30) AHKQWSAZYDKADK-UHFFFAOYSA-N 262527 4'-{[(1-cyclopentylpiperidin- 4-yl)amino]methyl}-2-(1H- tetrazol-5-yl)biphenyl-3- sulfonamide::US9708336, 379 Metallo-beta-lactamase type 2 318 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262527 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262527&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 122687737 376224354 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496735 NS(=O)(=O)c1cccc(-c2ccc(CNCC3(O)CC3)cc2)c1-c1nnn[nH]1 InChI=1S/C18H20N6O3S/c19-28(26,27)15-3-1-2-14(16(15)17-21-23-24-22-17)13-6-4-12(5-7-13)10-20-11-18(25)8-9-18/h1-7,20,25H,8-11H2,(H2,19,26,27)(H,21,22,23,24) HSFWWKNUWWWSDV-UHFFFAOYSA-N 262528 4'-({[(1- hydroxycyclopropyl)methyl] amino}methyl)-2-(1H- tetrazol-5-yl)biphenyl-3- sulfonamide::US9708336, 380 Metallo-beta-lactamase type 2 335 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262528 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262528&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266260 376224355 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496738 NS(=O)(=O)c1cccc(-c2ccc(CNCc3nn[nH]n3)cc2)c1-c1nnn[nH]1 InChI=1S/C16H16N10O2S/c17-29(27,28)13-3-1-2-12(15(13)16-21-25-26-22-16)11-6-4-10(5-7-11)8-18-9-14-19-23-24-20-14/h1-7,18H,8-9H2,(H2,17,27,28)(H,19,20,23,24)(H,21,22,25,26) QTTGVXPSDPEJHO-UHFFFAOYSA-N 262529 2-(1H-tetrazol-5-yl)-4'- {[(2H-tetrazol-5- ylmethyl)amino]methyl} biphenyl-3-sulfonamide::US9708336, 381 Metallo-beta-lactamase type 2 25.4 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262529 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262529&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266249 376224356 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496741 NS(=O)(=O)c1cccc(-c2ccc(CNCCc3ncc[nH]3)cc2)c1-c1nnn[nH]1 InChI=1S/C19H20N8O2S/c20-30(28,29)16-3-1-2-15(18(16)19-24-26-27-25-19)14-6-4-13(5-7-14)12-21-9-8-17-22-10-11-23-17/h1-7,10-11,21H,8-9,12H2,(H,22,23)(H2,20,28,29)(H,24,25,26,27) KBRSVFXNCUSVQT-UHFFFAOYSA-N 262530 4'-({[2-(1H-imidazol-2- yl)ethyl]amino}methyl)-2- (1H-tetrazol-5-yl)biphenyl- 3-sulfonamide::US9708336, 382 Metallo-beta-lactamase type 2 212 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262530 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262530&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823600 376224357 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496744 NS(=O)(=O)c1cccc(-c2ccc(CNCCn3nccn3)cc2)c1-c1nnn[nH]1 InChI=1S/C18H19N9O2S/c19-30(28,29)16-3-1-2-15(17(16)18-23-25-26-24-18)14-6-4-13(5-7-14)12-20-10-11-27-21-8-9-22-27/h1-9,20H,10-12H2,(H2,19,28,29)(H,23,24,25,26) DFKUHBKQERDHBF-UHFFFAOYSA-N 262531 2-(1H-tetrazol-5-yl)-4'-({[2- (2H-1,2,3-triazol-2- yl)ethyl]amino}methyl) biphenyl-3-sulfonamide::US9708336, 383 Metallo-beta-lactamase type 2 51.6 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262531 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262531&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823601 376224358 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 495706 Cc1csc(n1)-c1cccc(c1-c1nn[nH]n1)S(N)(=O)=O InChI=1S/C11H10N6O2S2/c1-6-5-20-11(13-6)7-3-2-4-8(21(12,18)19)9(7)10-14-16-17-15-10/h2-5H,1H3,(H2,12,18,19)(H,14,15,16,17) TXENJFOQKXIYFU-UHFFFAOYSA-N 262185 3-(4-methyl-1,3-thiazol-2-yl)- 2-(2H-tetrazol-5- yl)benzenesulfonamide::US9708336, 34 Metallo-beta-lactamase type 2 3094 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262185 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262185&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266319 376224013 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 495709 NS(=O)(=O)c1cccc(-c2nccs2)c1-c1nn[nH]n1 InChI=1S/C10H8N6O2S2/c11-20(17,18)7-3-1-2-6(10-12-4-5-19-10)8(7)9-13-15-16-14-9/h1-5H,(H2,11,17,18)(H,13,14,15,16) UWOZDNNJTRQYCG-UHFFFAOYSA-N 262186 2-(2H-tetrazol-5-yl)-3-(1,3- thiazol-2- yl)benzenesulfonamide::US9708336, 35 Metallo-beta-lactamase type 2 2683 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262186 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262186&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266321 376224014 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 495712 NS(=O)(=O)c1cccc(-c2cccc(F)n2)c1-c1nn[nH]n1 InChI=1S/C12H9FN6O2S/c13-10-6-2-4-8(15-10)7-3-1-5-9(22(14,20)21)11(7)12-16-18-19-17-12/h1-6H,(H2,14,20,21)(H,16,17,18,19) JCGDMKSFDTYZNJ-UHFFFAOYSA-N 262187 3-(6-fluoropyridin-2-yl)-2- (2H-tetrazol-5- yl)benzenesulfonamide::US9708336, 36 Metallo-beta-lactamase type 2 790 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262187 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262187&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823483 376224015 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 495715 COc1cccc(n1)-c1cccc(c1-c1nn[nH]n1)S(N)(=O)=O InChI=1S/C13H12N6O3S/c1-22-11-7-3-5-9(15-11)8-4-2-6-10(23(14,20)21)12(8)13-16-18-19-17-13/h2-7H,1H3,(H2,14,20,21)(H,16,17,18,19) HZGGUCFGNKLGIK-UHFFFAOYSA-N 262188 3-(6-methoxypyridin-2-yl)-2- (2H-tetrazol-5- yl)benzenesulfonamide::US9708336, 37 Metallo-beta-lactamase type 2 1211 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262188 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262188&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823484 376224016 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 495718 Cn1ccnc1-c1cccc(c1-c1nn[nH]n1)S(N)(=O)=O InChI=1S/C11H11N7O2S/c1-18-6-5-13-11(18)7-3-2-4-8(21(12,19)20)9(7)10-14-16-17-15-10/h2-6H,1H3,(H2,12,19,20)(H,14,15,16,17) SLGNPIUKDLPKGY-UHFFFAOYSA-N 262189 3-(1-methyl-1H-imidazol-2- yl)-2-(2H-tetrazol-5- yl)benzenesulfonamide::US9708336, 38 Metallo-beta-lactamase type 2 2392 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262189 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262189&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266320 376224017 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 495721 NS(=O)(=O)c1cccc(-c2ncccn2)c1-c1nn[nH]n1 InChI=1S/C11H9N7O2S/c12-21(19,20)8-4-1-3-7(10-13-5-2-6-14-10)9(8)11-15-17-18-16-11/h1-6H,(H2,12,19,20)(H,15,16,17,18) IFZAEOQZFRPOOQ-UHFFFAOYSA-N 262190 3-pyrimidin-2-yl-2-(2H- tetrazol-5- yl)benzenesulfonamide::US9708336, 39 Metallo-beta-lactamase type 2 2574 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262190 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262190&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823485 376224018 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 495724 COc1cncc(n1)-c1cccc(c1-c1nn[nH]n1)S(N)(=O)=O InChI=1S/C12H11N7O3S/c1-22-10-6-14-5-8(15-10)7-3-2-4-9(23(13,20)21)11(7)12-16-18-19-17-12/h2-6H,1H3,(H2,13,20,21)(H,16,17,18,19) OUYROUYAJBKDMP-UHFFFAOYSA-N 262191 3-(6-methoxypyrazin-2-yl)-2- (2H-tetrazol-5- yl)benzenesulfonamide::US9708336, 40 Metallo-beta-lactamase type 2 3048 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262191 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262191&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823486 376224019 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 495727 NS(=O)(=O)c1cccc(-c2ccco2)c1-c1nn[nH]n1 InChI=1S/C11H9N5O3S/c12-20(17,18)9-5-1-3-7(8-4-2-6-19-8)10(9)11-13-15-16-14-11/h1-6H,(H2,12,17,18)(H,13,14,15,16) FBAAIVKICHEJJY-UHFFFAOYSA-N 262192 3-furan-2-yl-2-(2H-tetrazol-5- yl)benzenesulfonamide::US9708336, 41 Metallo-beta-lactamase type 2 247 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262192 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262192&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266325 376224020 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 495730 NS(=O)(=O)c1cccc(-c2cncnc2)c1-c1nn[nH]n1 InChI=1S/C11H9N7O2S/c12-21(19,20)9-3-1-2-8(7-4-13-6-14-5-7)10(9)11-15-17-18-16-11/h1-6H,(H2,12,19,20)(H,15,16,17,18) WMVSWBJVVVFAJU-UHFFFAOYSA-N 262193 3-pyrimidin-5-yl-2-(2H- tetrazol-5- yl)benzenesulfonamide::US9708336, 42 Metallo-beta-lactamase type 2 10520 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262193 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262193&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823487 376224021 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 495733 Cn1cncc1-c1cccc(c1-c1nn[nH]n1)S(N)(=O)=O InChI=1S/C11H11N7O2S/c1-18-6-13-5-8(18)7-3-2-4-9(21(12,19)20)10(7)11-14-16-17-15-11/h2-6H,1H3,(H2,12,19,20)(H,14,15,16,17) NUEMBVKYFQRGFO-UHFFFAOYSA-N 262194 3-(1-methyl-1H-imidazol-5- yl)-2-(2H-tetrazol-5- yl)benzenesulfonamide::US9708336, 43 Metallo-beta-lactamase type 2 2094 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262194 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262194&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266442 376224022 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 495736 NS(=O)(=O)c1cccc(-c2cncs2)c1-c1nn[nH]n1 InChI=1S/C10H8N6O2S2/c11-20(17,18)8-3-1-2-6(7-4-12-5-19-7)9(8)10-13-15-16-14-10/h1-5H,(H2,11,17,18)(H,13,14,15,16) BEDOJMAHPWVNML-UHFFFAOYSA-N 262195 2-(2H-tetrazol-5-yl)-3-(1,3- thiazol-5- yl)benzenesulfonamide::US9708336, 44 Metallo-beta-lactamase type 2 293 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262195 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262195&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266444 376224023 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 495739 NS(=O)(=O)c1cccc(-c2cscn2)c1-c1nn[nH]n1 InChI=1S/C10H8N6O2S2/c11-20(17,18)8-3-1-2-6(7-4-19-5-12-7)9(8)10-13-15-16-14-10/h1-5H,(H2,11,17,18)(H,13,14,15,16) VGRCQXJFMQDVKF-UHFFFAOYSA-N 262196 2-(2H-tetrazol-5-yl)-3-(1,3- thiazol-4- yl)benzenesulfonamide::US9708336, 45 Metallo-beta-lactamase type 2 1206 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262196 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262196&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266433 376224024 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 495742 NS(=O)(=O)c1cccc(-c2ccnc(F)c2)c1-c1nn[nH]n1 InChI=1S/C12H9FN6O2S/c13-10-6-7(4-5-15-10)8-2-1-3-9(22(14,20)21)11(8)12-16-18-19-17-12/h1-6H,(H2,14,20,21)(H,16,17,18,19) CRNBYVVOZZXRQD-UHFFFAOYSA-N 262197 3-(2-fluoropyridin-4-yl)-2- (2H-tetrazol-5- yl)benzenesulfonamide::US9708336, 46 Metallo-beta-lactamase type 2 302 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262197 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262197&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823488 376224025 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 495745 NS(=O)(=O)c1cccc(-c2ccnnc2)c1-c1nn[nH]n1 InChI=1S/C11H9N7O2S/c12-21(19,20)9-3-1-2-8(7-4-5-13-14-6-7)10(9)11-15-17-18-16-11/h1-6H,(H2,12,19,20)(H,15,16,17,18) MVPWNLSVJDAOKD-UHFFFAOYSA-N 262198 3-pyridazin-4-yl-2-(2H- tetrazol-5- yl)benzenesulfonamide::US9708336, 47 Metallo-beta-lactamase type 2 4156 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262198 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262198&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823489 376224026 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 495748 NS(=O)(=O)c1cccc(-c2ccc(F)nc2)c1-c1nn[nH]n1 InChI=1S/C12H9FN6O2S/c13-10-5-4-7(6-15-10)8-2-1-3-9(22(14,20)21)11(8)12-16-18-19-17-12/h1-6H,(H2,14,20,21)(H,16,17,18,19) YPOXOCQUNAZIHZ-UHFFFAOYSA-N 262199 3-(6-fluoropyridin-3-yl)-2- (2H-tetrazol-5- yl)benzenesulfonamide::US9708336, 48 Metallo-beta-lactamase type 2 644 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262199 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262199&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823490 376224027 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 495751 Cn1nccc1-c1cccc(c1-c1nn[nH]n1)S(N)(=O)=O InChI=1S/C11H11N7O2S/c1-18-8(5-6-13-18)7-3-2-4-9(21(12,19)20)10(7)11-14-16-17-15-11/h2-6H,1H3,(H2,12,19,20)(H,14,15,16,17) ZWSVXWKXOMDTMS-UHFFFAOYSA-N 262200 3-(1-methyl-1H-pyrazol-5-yl)- 2-(2H-tetrazol-5- yl)benzenesulfonamide::US9708336, 49 Metallo-beta-lactamase type 2 4047 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262200 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262200&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266436 376224028 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 495754 NS(=O)(=O)c1cccc(-c2ccc(cc2)-c2ccn[nH]2)c1-c1nn[nH]n1 InChI=1S/C16H13N7O2S/c17-26(24,25)14-3-1-2-12(15(14)16-20-22-23-21-16)10-4-6-11(7-5-10)13-8-9-18-19-13/h1-9H,(H,18,19)(H2,17,24,25)(H,20,21,22,23) SAIBXYGCMZRCKX-UHFFFAOYSA-N 262201 4'-(1H-pyrazol-5-yl)-2-(2H- tetrazol-5-yl)biphenyl-3- sulfonamide::US9708336, 50 Metallo-beta-lactamase type 2 37.9 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262201 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262201&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823491 376224029 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 495757 COC1CCN(CC1)C(=O)c1ccc(cc1)-c1cccc(c1-c1nn[nH]n1)S(N)(=O)=O InChI=1S/C20H22N6O4S/c1-30-15-9-11-26(12-10-15)20(27)14-7-5-13(6-8-14)16-3-2-4-17(31(21,28)29)18(16)19-22-24-25-23-19/h2-8,15H,9-12H2,1H3,(H2,21,28,29)(H,22,23,24,25) LRJOGHQUBZBPHF-UHFFFAOYSA-N 262202 4'-[(4-methoxypiperidin-1- yl)carbonyl]-2-(2H-tetrazol- 5-yl)biphenyl-3-sulfonamide::US9708336, 51 Metallo-beta-lactamase type 2 27.4 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262202 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262202&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823492 376224030 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 495760 NS(=O)(=O)c1cccc(-c2ccc(cc2)C(=O)N2CCC(O)CC2)c1-c1nn[nH]n1 InChI=1S/C19H20N6O4S/c20-30(28,29)16-3-1-2-15(17(16)18-21-23-24-22-18)12-4-6-13(7-5-12)19(27)25-10-8-14(26)9-11-25/h1-7,14,26H,8-11H2,(H2,20,28,29)(H,21,22,23,24) JLLHAXPAMPPUFN-UHFFFAOYSA-N 262203 4'-[(4-hydroxypiperidin-1- yl)carbonyl]-2-(2H-tetrazol- 5-yl)biphenyl-3-sulfonamide::US9708336, 52 Metallo-beta-lactamase type 2 17.9 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262203 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262203&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823493 376224031 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 495763 NS(=O)(=O)c1cccc(-c2ccc3CNC(=O)c3c2)c1-c1nn[nH]n1 InChI=1S/C15H12N6O3S/c16-25(23,24)12-3-1-2-10(13(12)14-18-20-21-19-14)8-4-5-9-7-17-15(22)11(9)6-8/h1-6H,7H2,(H,17,22)(H2,16,23,24)(H,18,19,20,21) CZDQZGFBFSPDLU-UHFFFAOYSA-N 262204 3-(3-oxo-2,3-dihydro-1H- isoindol-5-yl)-2-(2H- tetrazol-5- yl)benzenesulfonamide::US9708336, 53 Metallo-beta-lactamase type 2 73.3 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262204 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262204&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823494 376224032 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 495766 CS(=O)(=O)CCn1cc(cn1)-c1cccc(c1-c1nn[nH]n1)S(N)(=O)=O InChI=1S/C13H15N7O4S2/c1-25(21,22)6-5-20-8-9(7-15-20)10-3-2-4-11(26(14,23)24)12(10)13-16-18-19-17-13/h2-4,7-8H,5-6H2,1H3,(H2,14,23,24)(H,16,17,18,19) JYQSKKXFGSQQTB-UHFFFAOYSA-N 262205 3-{1-[2- (methylsulfonyl)ethyl]-1H- pyrazol-4-yl}-2-(2H-tetrazol- 5-yl)benzenesulfonamide::US9708336, 54 Metallo-beta-lactamase type 2 205 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262205 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262205&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266165 376224033 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 495769 CN(c1ncc(cn1)-c1cccc(c1-c1nn[nH]n1)S(N)(=O)=O)S(C)(=O)=O InChI=1S/C13H14N8O4S2/c1-21(26(2,22)23)13-15-6-8(7-16-13)9-4-3-5-10(27(14,24)25)11(9)12-17-19-20-18-12/h3-7H,1-2H3,(H2,14,24,25)(H,17,18,19,20) VUAVKOLRCXEVJQ-UHFFFAOYSA-N 262206 3-{2-[methyl(methyl sulfonyl)amino]pyrimidin-5- yl}-2-(2H-tetrazol-5- yl)benzenesulfonamide::US9708336, 55 Metallo-beta-lactamase type 2 52.7 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262206 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262206&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823495 376224034 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496747 NS(=O)(=O)c1cccc(-c2ccc(CNCCc3c[nH]cn3)cc2)c1-c1nnn[nH]1 InChI=1S/C19H20N8O2S/c20-30(28,29)17-3-1-2-16(18(17)19-24-26-27-25-19)14-6-4-13(5-7-14)10-21-9-8-15-11-22-12-23-15/h1-7,11-12,21H,8-10H2,(H,22,23)(H2,20,28,29)(H,24,25,26,27) MRDBAZVABWVADZ-UHFFFAOYSA-N 262532 4'-({[2-(1H-imidazol-4- yl)ethyl]amino}methyl)-2- (1H-tetrazol-5-yl)biphenyl- 3-sulfonamide::US9708336, 384 Metallo-beta-lactamase type 2 293 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262532 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262532&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823602 376224359 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496750 NS(=O)(=O)c1cccc(-c2ccc(CNCCc3cn[nH]c3)cc2)c1-c1nnn[nH]1 InChI=1S/C19H20N8O2S/c20-30(28,29)17-3-1-2-16(18(17)19-24-26-27-25-19)15-6-4-13(5-7-15)10-21-9-8-14-11-22-23-12-14/h1-7,11-12,21H,8-10H2,(H,22,23)(H2,20,28,29)(H,24,25,26,27) URJWBFGTEYGRDN-UHFFFAOYSA-N 262533 4'-({[2-(1H-pyrazol-4- yl)ethyl]amino}methyl)-2- (1H-tetrazol-5-yl)biphenyl- 3-sulfonamide::US9708336, 385 Metallo-beta-lactamase type 2 499 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262533 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262533&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266529 376224360 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496753 NS(=O)(=O)c1cccc(-c2ccc(CN3CCNC(=O)C3)cc2)c1-c1nnn[nH]1 InChI=1S/C18H19N7O3S/c19-29(27,28)15-3-1-2-14(17(15)18-21-23-24-22-18)13-6-4-12(5-7-13)10-25-9-8-20-16(26)11-25/h1-7H,8-11H2,(H,20,26)(H2,19,27,28)(H,21,22,23,24) OMZBOWIZJFXPIF-UHFFFAOYSA-N 262534 4'-[(3-oxopiperazin-1- yl)methyl]-2-(1H-tetrazol-5- yl)biphenyl-3-sulfonamide::US9708336, 386 Metallo-beta-lactamase type 2 32.0 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262534 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262534&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266531 376224361 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496756 NS(=O)(=O)c1cccc(-c2ccc(CN3C[C@H](O)C[C@H]3CO)cc2)c1-c1nnn[nH]1 262535 4'-{[(2S,4R)-4-hydroxy-2- (hydroxymethyl)pyrrolidin- 1-yl]methyl}-2-(1H-tetrazol- 5-yl)biphenyl-3-sulfonamide::US9708336, 387 Metallo-beta-lactamase type 2 145 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262535 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262535&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266193 376224362 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496759 NS(=O)(=O)c1cccc(-c2ccc(CNC3CCNC3=O)cc2)c1-c1nnn[nH]1 262536 4'-{[(2-oxopyrrolidin-3- yl)amino]methyl}-2-(1H- tetrazol-5-yl)biphenyl-3- sulfonamide::US9708336, 388 Metallo-beta-lactamase type 2 48.6 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262536 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262536&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 122687752 376224363 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496762 NS(=O)(=O)c1cccc(-c2ccc(CNCCc3cc[nH]n3)cc2)c1-c1nnn[nH]1 InChI=1S/C19H20N8O2S/c20-30(28,29)17-3-1-2-16(18(17)19-24-26-27-25-19)14-6-4-13(5-7-14)12-21-10-8-15-9-11-22-23-15/h1-7,9,11,21H,8,10,12H2,(H,22,23)(H2,20,28,29)(H,24,25,26,27) VSDHSOMEXPXJJI-UHFFFAOYSA-N 262537 4'-({[2-(1H-pyrazol-3- yl)ethyl]amino}methyl)-2- (1H-tetrazol-5-yl)biphenyl- 3-sulfonamide::US9708336, 389 Metallo-beta-lactamase type 2 64.0 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262537 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262537&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266196 376224364 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496765 NS(=O)(=O)c1cccc(-c2ccc(CNCCO)cc2)c1-c1nnn[nH]1 InChI=1S/C16H18N6O3S/c17-26(24,25)14-3-1-2-13(15(14)16-19-21-22-20-16)12-6-4-11(5-7-12)10-18-8-9-23/h1-7,18,23H,8-10H2,(H2,17,24,25)(H,19,20,21,22) RKDCZKCSGCNRJC-UHFFFAOYSA-N 262538 4'-{[(2- hydroxyethyl)amino]methyl}- 2-(1H-tetrazol-5- yl)biphenyl-3-sulfonamide::US9708336, 390 Metallo-beta-lactamase type 2 483 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262538 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262538&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266191 376224365 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496768 NS(=O)(=O)c1cccc(-c2ccc(CN3CC[C@@H](CO)C3)cc2)c1-c1nnn[nH]1 262539 4'-{[(3S)-3- (hydroxymethyl)pyrrolidin- 1-yl]methyl}-2-(1H-tetrazol- 5-yl)biphenyl-3-sulfonamide::US9708336, 391 Metallo-beta-lactamase type 2 348 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262539 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262539&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266198 376224366 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496771 NS(=O)(=O)c1cccc(-c2ccc(CN3CC[C@H](CO)C3)cc2)c1-c1nnn[nH]1 262540 4'-{[(3S)-3- (hydroxymethyl)pyrrolidin- l-yl]methyl}-2-(1H-tetrazol- 5-yl)biphenyl-3-sulfonamide::US9708336, 392 Metallo-beta-lactamase type 2 394 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262540 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262540&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118265967 376224367 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496774 NS(=O)(=O)c1cccc(-c2ccc(CN3CCC(CCO)C3)cc2)c1-c1nnn[nH]1 262541 4'-{[3-(2- hydroxyethyl)pyrrolidin-1- yl]methyl}-2-(1H-tetrazol-5- yl)biphenyl-3-sulfonamide::US9708336, 393 Metallo-beta-lactamase type 2 338 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262541 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262541&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118265968 376224368 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496777 NS(=O)(=O)c1cccc(-c2ccc(CN3CCC(O)CC3)cc2)c1-c1nnn[nH]1 InChI=1S/C19H22N6O3S/c20-29(27,28)17-3-1-2-16(18(17)19-21-23-24-22-19)14-6-4-13(5-7-14)12-25-10-8-15(26)9-11-25/h1-7,15,26H,8-12H2,(H2,20,27,28)(H,21,22,23,24) LXDNTVPVISUUQN-UHFFFAOYSA-N 262542 4'-[(4-hydroxypiperidin-1- yl)methyl]-2-(1H-tetrazol-5- yl)biphenyl-3-sulfonamide::US9708336, 394 Metallo-beta-lactamase type 2 195 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262542 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262542&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118265969 376224369 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496780 NS(=O)(=O)c1cccc(-c2ccc(CN3CCCC3CO)cc2)c1-c1nnn[nH]1 262543 4'-{[2- (hydroxymethyl)pyrrolidin- 1-yl]methyl}-2-(1H-tetrazol- 5-yl)biphenyl-3-sulfonamide::US9708336, 395 Metallo-beta-lactamase type 2 226 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262543 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262543&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118265970 376224370 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496783 NS(=O)(=O)c1cccc(-c2ccc(CN3CC(O)C(F)C3)cc2)c1-c1nnn[nH]1 262544 4'-[(3-fluoro-4- hydroxypyrrolidin-1- yl)methyl]-2-(1H-tetrazol-5- yl)biphenyl-3-sulfonamide::US9708336, 396 Metallo-beta-lactamase type 2 22.4 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262544 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262544&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266275 376224371 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496786 CCOCc1ccc(cc1)-c1cccc(c1-c1nnn[nH]1)S(N)(=O)=O InChI=1S/C16H17N5O3S/c1-2-24-10-11-6-8-12(9-7-11)13-4-3-5-14(25(17,22)23)15(13)16-18-20-21-19-16/h3-9H,2,10H2,1H3,(H2,17,22,23)(H,18,19,20,21) UCDZWNIUBLQJCS-UHFFFAOYSA-N 262545 4′-(Ethoxymethyl)-2-(1H-tetrazol-5-yl)-[1,1′-biphenyl]-3-sulfonamide::US9708336, 397 Metallo-beta-lactamase type 2 37.3 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262545 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262545&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118257251 376224372 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496789 Cc1ccc(nc1)-c1cccc(c1-c1nnn[nH]1)S(N)(=O)=O InChI=1S/C13H12N6O2S/c1-8-5-6-10(15-7-8)9-3-2-4-11(22(14,20)21)12(9)13-16-18-19-17-13/h2-7H,1H3,(H2,14,20,21)(H,16,17,18,19) ZCMCGXBQFPDRRS-UHFFFAOYSA-N 262546 3-(5-Methylpyridin-2-yl)-2-(1H-tetrazol-5-yl)benzenesulfonamide, TFA Salt::US9708336, 398 Metallo-beta-lactamase type 2 1214 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262546 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262546&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118256950 376224373 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496792 NS(=O)(=O)c1ccc2ccccc2c1-c1nnn[nH]1 InChI=1S/C11H9N5O2S/c12-19(17,18)9-6-5-7-3-1-2-4-8(7)10(9)11-13-15-16-14-11/h1-6H,(H2,12,17,18)(H,13,14,15,16) AKHKLHLESITHHL-UHFFFAOYSA-N 262547 1-(1H-tetrazol-5-yl)naphthalene-2-sulfonamide::US9708336, 399 Metallo-beta-lactamase type 2 15100 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262547 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262547&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118256949 376224374 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496795 Nc1nccc2ccc(cc12)-c1cccc(c1-c1nnn[nH]1)S(N)(=O)=O InChI=1S/C16H13N7O2S/c17-15-12-8-10(5-4-9(12)6-7-19-15)11-2-1-3-13(26(18,24)25)14(11)16-20-22-23-21-16/h1-8H,(H2,17,19)(H2,18,24,25)(H,20,21,22,23) LLVCLLGPMXTTSO-UHFFFAOYSA-N 262548 3-(1-aminoisoquinolin-7-yl)-2-(1H-tetrazol-5-yl)benzenesulfonamide::US9708336, 400 Metallo-beta-lactamase type 2 166 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262548 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262548&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118257012 376224375 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496798 Nc1ccnc2ccc(cc12)-c1cccc(c1-c1nnn[nH]1)S(N)(=O)=O InChI=1S/C16H13N7O2S/c17-12-6-7-19-13-5-4-9(8-11(12)13)10-2-1-3-14(26(18,24)25)15(10)16-20-22-23-21-16/h1-8H,(H2,17,19)(H2,18,24,25)(H,20,21,22,23) VKMSQYORQICPDL-UHFFFAOYSA-N 262549 3-(4-amino-6-quinolyl)-2-(1H- tetrazol-5-yl)benzenesulfonamide::US9708336, 401 Metallo-beta-lactamase type 2 646 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262549 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262549&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266642 376224376 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496801 Nc1cnc(cn1)-c1cccc(c1-c1nnn[nH]1)S(N)(=O)=O InChI=1S/C11H10N8O2S/c12-9-5-14-7(4-15-9)6-2-1-3-8(22(13,20)21)10(6)11-16-18-19-17-11/h1-5H,(H2,12,15)(H2,13,20,21)(H,16,17,18,19) FCKHVVWFICTGJX-UHFFFAOYSA-N 262550 3-(5-aminopyrazin-2-yl)-2-(1H- tetrazol-5-yl)benzenesulfonamide::US9708336, 402 Metallo-beta-lactamase type 2 389 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262550 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262550&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266643 376224377 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496804 Nc1ccc2cc(ccc2n1)-c1cccc(c1-c1nnn[nH]1)S(N)(=O)=O InChI=1S/C16H13N7O2S/c17-14-7-5-10-8-9(4-6-12(10)19-14)11-2-1-3-13(26(18,24)25)15(11)16-20-22-23-21-16/h1-8H,(H2,17,19)(H2,18,24,25)(H,20,21,22,23) ZOSVSIKFGKBUET-UHFFFAOYSA-N 262551 3-(2-amino-6-quinolyl)-2-(1H- tetrazol-5-yl)benzenesulfonamide::US9708336, 403 Metallo-beta-lactamase type 2 184 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262551 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262551&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266641 376224378 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496807 NS(=O)(=O)c1cccc(-c2cnc3ccccn23)c1-c1nnn[nH]1 InChI=1S/C14H11N7O2S/c15-24(22,23)11-5-3-4-9(13(11)14-17-19-20-18-14)10-8-16-12-6-1-2-7-21(10)12/h1-8H,(H2,15,22,23)(H,17,18,19,20) AWWMFBQJUZWFHJ-UHFFFAOYSA-N 262552 3-imidazo[1,2-a]pyridin-3-yl-2- (1H-tetrazol-5- yl)benzenesulfonamide::US9708336, 404 Metallo-beta-lactamase type 2 71.4 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262552 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262552&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266539 376224379 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496810 NS(=O)(=O)c1cccc(-c2ccc3nccnc3c2)c1-c1nnn[nH]1 InChI=1S/C15H11N7O2S/c16-25(23,24)13-3-1-2-10(14(13)15-19-21-22-20-15)9-4-5-11-12(8-9)18-7-6-17-11/h1-8H,(H2,16,23,24)(H,19,20,21,22) QQKYZIBVHTZTAI-UHFFFAOYSA-N 262553 3-quinoxalin-6-yl-2-(1H-tetrazol- 5-yl)benzenesulfonamide::US9708336, 405 Metallo-beta-lactamase type 2 67.6 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262553 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262553&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823603 376224380 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 495772 NS(=O)(=O)c1cccc(-c2ccc3OCCOc3c2)c1-c1nn[nH]n1 InChI=1S/C15H13N5O4S/c16-25(21,22)13-3-1-2-10(14(13)15-17-19-20-18-15)9-4-5-11-12(8-9)24-7-6-23-11/h1-5,8H,6-7H2,(H2,16,21,22)(H,17,18,19,20) BMFLVEDSFLBLMM-UHFFFAOYSA-N 262207 3-(2,3-dihydro-1,4- benzodioxin-6-yl)-2-(2H- tetrazol-5- yl)benzenesulfonamide::US9708336, 56 Metallo-beta-lactamase type 2 13.2 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262207 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262207&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823496 376224035 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 495775 CNS(=O)(=O)c1ccc(cc1)-c1cccc(c1-c1nn[nH]n1)S(N)(=O)=O InChI=1S/C14H14N6O4S2/c1-16-26(23,24)10-7-5-9(6-8-10)11-3-2-4-12(25(15,21)22)13(11)14-17-19-20-18-14/h2-8,16H,1H3,(H2,15,21,22)(H,17,18,19,20) JDELDOBDHLNUKD-UHFFFAOYSA-N 262208 N~4~-'-methyl-2-(2H- tetrazol-5-yl)biphenyl-3,4'- disulfonamide::US9708336, 57 Metallo-beta-lactamase type 2 28.9 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262208 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262208&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823497 376224036 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 495778 CS(=O)(=O)c1ccc(cn1)-c1cccc(c1-c1nn[nH]n1)S(N)(=O)=O InChI=1S/C13H12N6O4S2/c1-24(20,21)11-6-5-8(7-15-11)9-3-2-4-10(25(14,22)23)12(9)13-16-18-19-17-13/h2-7H,1H3,(H2,14,22,23)(H,16,17,18,19) FVUHOKRZIOIBNA-UHFFFAOYSA-N 262209 3-[6- (methylsulfonyl)pyridin-3- yl]-2-(2H-tetrazol-5- yl)benzenesulfonamide::US9708336, 58 Metallo-beta-lactamase type 2 227 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262209 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262209&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823498 376224037 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 495781 CN(C)S(=O)(=O)c1ccc(cc1)-c1cccc(c1-c1nn[nH]n1)S(N)(=O)=O InChI=1S/C15H16N6O4S2/c1-21(2)27(24,25)11-8-6-10(7-9-11)12-4-3-5-13(26(16,22)23)14(12)15-17-19-20-18-15/h3-9H,1-2H3,(H2,16,22,23)(H,17,18,19,20) VGEOOPSTEUQVJA-UHFFFAOYSA-N 262210 N~4~',N~4~'-dimethyl-2- (2H-tetrazol-5-yl)biphenyl- 3,4'-disulfonamide::US9708336, 59 Metallo-beta-lactamase type 2 36.1 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262210 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262210&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823499 376224038 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 495784 NS(=O)(=O)c1cccc(-c2ccc(cc2)S(=O)(=O)NC2CC2)c1-c1nn[nH]n1 InChI=1S/C16H16N6O4S2/c17-27(23,24)14-3-1-2-13(15(14)16-18-21-22-19-16)10-4-8-12(9-5-10)28(25,26)20-11-6-7-11/h1-5,8-9,11,20H,6-7H2,(H2,17,23,24)(H,18,19,21,22) MVWXSYVNYQJRJM-UHFFFAOYSA-N 262211 N~4~'-cyclopropyl-2-(2H- tetrazol-5-yl)biphenyl-3,4'- disulfonamide::US9708336, 60 Metallo-beta-lactamase type 2 16.5 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262211 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262211&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823500 376224039 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 495787 NS(=O)(=O)c1ccc(cc1)-c1cccc(c1-c1nn[nH]n1)S(N)(=O)=O InChI=1S/C13H12N6O4S2/c14-24(20,21)9-6-4-8(5-7-9)10-2-1-3-11(25(15,22)23)12(10)13-16-18-19-17-13/h1-7H,(H2,14,20,21)(H2,15,22,23)(H,16,17,18,19) ZYGSZYUZHGJXAJ-UHFFFAOYSA-N 262212 2-(2H-tetrazol-5-yl)biphenyl- 3,4'-disulfonamide::US9708336, 61 Metallo-beta-lactamase type 2 58.0 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262212 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262212&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823501 376224040 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 495790 NS(=O)(=O)c1cccc(C2=CCSCC2)c1-c1nn[nH]n1 InChI=1S/C12H13N5O2S2/c13-21(18,19)10-3-1-2-9(8-4-6-20-7-5-8)11(10)12-14-16-17-15-12/h1-4H,5-7H2,(H2,13,18,19)(H,14,15,16,17) NPPZCTFCEXLWMJ-UHFFFAOYSA-N 262213 3-(3,6-dihydro-2H- thiopyran-4-yl)-2-(2H- tetrazol-5- yl)benzenesulfonamide::US9708336, 62 Metallo-beta-lactamase type 2 211 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262213 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262213&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266176 376224041 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 495793 NS(=O)(=O)c1cccc(C2=CCCOC2)c1-c1nn[nH]n1 InChI=1S/C12H13N5O3S/c13-21(18,19)10-5-1-4-9(8-3-2-6-20-7-8)11(10)12-14-16-17-15-12/h1,3-5H,2,6-7H2,(H2,13,18,19)(H,14,15,16,17) YIYYBRHHRAIYIM-UHFFFAOYSA-N 262214 3-(5,6-dihydro-2H-pyran-3- yl)-2-(2H-tetrazol-5- yl)benzenesulfonamide::US9708336, 63 Metallo-beta-lactamase type 2 1557 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262214 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262214&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266174 376224042 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 495796 NS(=O)(=O)c1cccc(C2=CCC(CC2)C#N)c1-c1nn[nH]n1 262215 3-(4-cyanocyclohex-1-en-1- yl)-2-(2H-tetrazol-5- yl)benzenesulfonamide::US9708336, 64 Metallo-beta-lactamase type 2 248 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262215 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262215&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266175 376224043 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 495799 CN1CCC=C(C1)c1cccc(c1-c1nn[nH]n1)S(N)(=O)=O InChI=1S/C13H16N6O2S/c1-19-7-3-4-9(8-19)10-5-2-6-11(22(14,20)21)12(10)13-15-17-18-16-13/h2,4-6H,3,7-8H2,1H3,(H2,14,20,21)(H,15,16,17,18) TUQRKJYEOQHBGZ-UHFFFAOYSA-N 262216 3-(1-methyl-1,2,5,6- tetrahydropyridin-3-yl)-2- (2H-tetrazol-5- yl)benzenesulfonamide::US9708336, 65 Metallo-beta-lactamase type 2 20000 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262216 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262216&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266180 376224044 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 495802 NS(=O)(=O)c1cccc(-c2ccc3ncccc3c2)c1-c1nn[nH]n1 InChI=1S/C16H12N6O2S/c17-25(23,24)14-5-1-4-12(15(14)16-19-21-22-20-16)10-6-7-13-11(9-10)3-2-8-18-13/h1-9H,(H2,17,23,24)(H,19,20,21,22) OBHBXKKZLFJBDL-UHFFFAOYSA-N 262217 3-quinolin-6-yl-2-(2H- tetrazol-5- yl)benzenesulfonamide::US9708336, 66 Metallo-beta-lactamase type 2 140 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262217 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262217&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266312 376224045 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 495805 Cn1nnc2ccc(cc12)-c1cccc(c1-c1nn[nH]n1)S(N)(=O)=O InChI=1S/C14H12N8O2S/c1-22-11-7-8(5-6-10(11)16-21-22)9-3-2-4-12(25(15,23)24)13(9)14-17-19-20-18-14/h2-7H,1H3,(H2,15,23,24)(H,17,18,19,20) FXYFWQNTXHFPJD-UHFFFAOYSA-N 262218 3-(1-methyl-1H- benzotriazol-6-yl)-2-(2H- tetrazol-5- yl)benzenesulfonamide::US9708336, 67 Metallo-beta-lactamase type 2 911 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262218 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262218&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266316 376224046 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 495808 Cn1ncc2cc(ccc12)-c1cccc(c1-c1nn[nH]n1)S(N)(=O)=O InChI=1S/C15H13N7O2S/c1-22-12-6-5-9(7-10(12)8-17-22)11-3-2-4-13(25(16,23)24)14(11)15-18-20-21-19-15/h2-8H,1H3,(H2,16,23,24)(H,18,19,20,21) HFXJZACIYJVKAW-UHFFFAOYSA-N 262219 3-(1-methyl-1H-indazol-5- yl)-2-(2H-tetrazol-5- yl)benzenesulfonamide::US9708336, 68 Metallo-beta-lactamase type 2 81.9 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262219 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262219&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266317 376224047 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 495811 NS(=O)(=O)c1cccc(-c2ccc3c(c2)[nH]cnc3=O)c1-c1nn[nH]n1 InChI=1S/C15H11N7O3S/c16-26(24,25)12-3-1-2-9(13(12)14-19-21-22-20-14)8-4-5-10-11(6-8)17-7-18-15(10)23/h1-7H,(H2,16,24,25)(H,17,18,23)(H,19,20,21,22) YBDCSLNPCKCWNZ-UHFFFAOYSA-N 262220 3-(4-oxo-1,4- dihydroquinazolin-7-yl)-2- (2H-tetrazol-5- yl)benzenesulfonamide::US9708336, 69 Metallo-beta-lactamase type 2 237 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262220 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262220&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823502 376224048 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 495814 NS(=O)(=O)c1cccc(-c2cccc(c2)-n2nccn2)c1-c1nn[nH]n1 InChI=1S/C15H12N8O2S/c16-26(24,25)13-6-2-5-12(14(13)15-19-21-22-20-15)10-3-1-4-11(9-10)23-17-7-8-18-23/h1-9H,(H2,16,24,25)(H,19,20,21,22) FLPQGCWMVBQIPZ-UHFFFAOYSA-N 262221 2-(2H-tetrazol-5-yl)-3'-(2H- 1,2,3-triazol-2-yl)biphenyl-3- sulfonamide::US9708336, 70 Metallo-beta-lactamase type 2 105 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262221 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262221&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823503 376224049 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 495817 NS(=O)(=O)c1cccc(-c2ccc3ccncc3c2)c1-c1nn[nH]n1 InChI=1S/C16H12N6O2S/c17-25(23,24)14-3-1-2-13(15(14)16-19-21-22-20-16)11-5-4-10-6-7-18-9-12(10)8-11/h1-9H,(H2,17,23,24)(H,19,20,21,22) FKTGBHFRENDWKQ-UHFFFAOYSA-N 262222 3-isoquinolin-7-yl-2-(2H- tetrazol-5- yl)benzenesulfonamide::US9708336, 71 Metallo-beta-lactamase type 2 78.6 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262222 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262222&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266315 376224050 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 495820 NS(=O)(=O)c1cccc(-c2ccc(cc2)-c2nnn[nH]2)c1-c1nn[nH]n1 InChI=1S/C14H11N9O2S/c15-26(24,25)11-3-1-2-10(12(11)14-18-22-23-19-14)8-4-6-9(7-5-8)13-16-20-21-17-13/h1-7H,(H2,15,24,25)(H,16,17,20,21)(H,18,19,22,23) LHEFWGXHCXOHIO-UHFFFAOYSA-N 262223 4'-(1H-tetrazol-5-yl)-2-(2H- tetrazol-5-yl)biphenyl-3- sulfonamide::US9708336, 72 Metallo-beta-lactamase type 2 48.7 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262223 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262223&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 122687798 376224051 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 495823 CC1C(=O)Nc2ccc(cc12)-c1cccc(c1-c1nn[nH]n1)S(N)(=O)=O 262224 3-(3-methyl-2-oxo-2,3- dihydro-1H-indo1-5-yl)-2- (2H-tetrazol-5- yl)benzenesulfonamide::US9708336, 73 Metallo-beta-lactamase type 2 156 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262224 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262224&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266313 376224052 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 495826 NS(=O)(=O)c1cccc(-c2ccc3[nH]nnc3c2)c1-c1nn[nH]n1 InChI=1S/C13H10N8O2S/c14-24(22,23)11-3-1-2-8(12(11)13-17-20-21-18-13)7-4-5-9-10(6-7)16-19-15-9/h1-6H,(H2,14,22,23)(H,15,16,19)(H,17,18,20,21) GEERSBZIHNWOEU-UHFFFAOYSA-N 262225 3-(1H-benzotriazol-5-yl)-2- (2H-tetrazol-5- yl)benzenesulfonamide::US9708336, 74 Metallo-beta-lactamase type 2 1610 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262225 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262225&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 122687760 376224053 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 495829 CC1(SC(=O)NC1=O)c1ccc(cc1)-c1cccc(c1-c1nn[nH]n1)S(N)(=O)=O 262226 4'-(5-methyl-2,4-dioxo-1,3- thiazolidin-5-yl)-2-(2H- tetrazol-5-yl)biphenyl-3- sulfonamide::US9708336, 75 Metallo-beta-lactamase type 2 9.96 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262226 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262226&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823504 376224054 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 495832 NS(=O)(=O)c1cccc(-c2ccc(CC3OC(=O)NC3=O)cc2)c1-c1nn[nH]n1 262227 4'-[(2,4-dioxo-1,3- oxazolidin-5-yl)methyl]-2- (2H-tetrazol-5-yl)biphenyl-3- sulfonamide::US9708336, 76 Metallo-beta-lactamase type 2 42.7 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262227 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262227&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266309 376224055 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 495835 CN(C1CCOCC1)C(=O)c1ccc(cc1)-c1cccc(c1-c1nn[nH]n1)S(N)(=O)=O InChI=1S/C20H22N6O4S/c1-26(15-9-11-30-12-10-15)20(27)14-7-5-13(6-8-14)16-3-2-4-17(31(21,28)29)18(16)19-22-24-25-23-19/h2-8,15H,9-12H2,1H3,(H2,21,28,29)(H,22,23,24,25) HJIFDXWVWJTFSI-UHFFFAOYSA-N 262228 N-methyl-3'-sulfamoyl-N- (tetrahydro-2H-pyran-4-yl)- 2'-(2H-tetrazol-5- yl)biphenyl-4-carboxamide::US9708336, 77 Metallo-beta-lactamase type 2 53.8 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262228 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262228&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823505 376224056 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496813 NS(=O)(=O)c1cccc(-c2ccnc3ncccc23)c1-c1nnn[nH]1 InChI=1S/C15H11N7O2S/c16-25(23,24)12-5-1-3-10(13(12)15-19-21-22-20-15)9-6-8-18-14-11(9)4-2-7-17-14/h1-8H,(H2,16,23,24)(H,19,20,21,22) RRWIPYUTAYFTBG-UHFFFAOYSA-N 262554 3-(1,8-naphthyridin-4-yl)-2-(1H- tetrazol-5-yl)benzenesulfonamide::US9708336, 406 Metallo-beta-lactamase type 2 250 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262554 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262554&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266537 376224381 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496816 NS(=O)(=O)c1cccc(-c2nc(cs2)-c2ccncc2)c1-c1nnn[nH]1 InChI=1S/C15H11N7O2S2/c16-26(23,24)12-3-1-2-10(13(12)14-19-21-22-20-14)15-18-11(8-25-15)9-4-6-17-7-5-9/h1-8H,(H2,16,23,24)(H,19,20,21,22) IMYYSBKTWGBXJY-UHFFFAOYSA-N 262555 3-[4-(4-pyridyl)thiazol-2-yl]-2- (1H-tetrazol-5- yl)benzenesulfonamide::US9708336, 407 Metallo-beta-lactamase type 2 115 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262555 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262555&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823604 376224382 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496819 NS(=O)(=O)c1cccc(-c2ccc3cnccc3c2)c1-c1nnn[nH]1 InChI=1S/C16H12N6O2S/c17-25(23,24)14-3-1-2-13(15(14)16-19-21-22-20-16)11-4-5-12-9-18-7-6-10(12)8-11/h1-9H,(H2,17,23,24)(H,19,20,21,22) ORMVZBOMDBGTDC-UHFFFAOYSA-N 262556 3-(6-isoquinolyl)-2-(1H-tetrazol-5- yl)benzenesulfonamide::US9708336, 408 Metallo-beta-lactamase type 2 84.3 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262556 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262556&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266542 376224383 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496822 NS(=O)(=O)c1cccc(-c2csc(n2)-c2ccncc2)c1-c1nnn[nH]1 InChI=1S/C15H11N7O2S2/c16-26(23,24)12-3-1-2-10(13(12)14-19-21-22-20-14)11-8-25-15(18-11)9-4-6-17-7-5-9/h1-8H,(H2,16,23,24)(H,19,20,21,22) PDPVVYHBAAEUMO-UHFFFAOYSA-N 262557 3-[2-(4-pyridyl)thiazol-4-yl]-2- (1H-tetrazol-5- yl)benzenesulfonamide::US9708336, 409 Metallo-beta-lactamase type 2 445 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262557 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262557&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823605 376224384 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496825 NS(=O)(=O)c1cccc(-c2cc3ccncc3s2)c1-c1nnn[nH]1 InChI=1S/C14H10N6O2S2/c15-24(21,22)12-3-1-2-9(13(12)14-17-19-20-18-14)10-6-8-4-5-16-7-11(8)23-10/h1-7H,(H2,15,21,22)(H,17,18,19,20) AYYTXZXWIFOUTK-UHFFFAOYSA-N 262558 2-(1H-tetrazol-5-yl)-3-thieno[2,3- c]pyridin-2-yl- benzenesulfonamide::US9708336, 410 Metallo-beta-lactamase type 2 107 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262558 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262558&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823606 376224385 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496828 NS(=O)(=O)c1cccc(-c2cc3cnccc3s2)c1-c1nnn[nH]1 InChI=1S/C14H10N6O2S2/c15-24(21,22)12-3-1-2-9(13(12)14-17-19-20-18-14)11-6-8-7-16-5-4-10(8)23-11/h1-7H,(H2,15,21,22)(H,17,18,19,20) XWCRJZYPNUATJP-UHFFFAOYSA-N 262559 2-(1H-tetrazol-5-yl)-3-thieno[3,2- c]pyridin-2-yl- benzenesulfonamide::US9708336, 411 Metallo-beta-lactamase type 2 102 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262559 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262559&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823607 376224386 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496831 Nc1ccnc2cc(ccc12)-c1cccc(c1-c1nnn[nH]1)S(N)(=O)=O InChI=1S/C16H13N7O2S/c17-12-6-7-19-13-8-9(4-5-11(12)13)10-2-1-3-14(26(18,24)25)15(10)16-20-22-23-21-16/h1-8H,(H2,17,19)(H2,18,24,25)(H,20,21,22,23) JQGGENTULHBLTK-UHFFFAOYSA-N 262560 3-(4-amino-7-quinolyl)-2-(1H- tetrazol-5-yl)benzenesulfonamide::US9708336, 412 Metallo-beta-lactamase type 2 1389 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262560 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262560&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823608 376224387 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496834 NS(=O)(=O)c1cccc(-c2snc3ncccc23)c1-c1nnn[nH]1 InChI=1S/C13H9N7O2S2/c14-24(21,22)9-5-1-3-7(10(9)13-16-19-20-17-13)11-8-4-2-6-15-12(8)18-23-11/h1-6H,(H2,14,21,22)(H,16,17,19,20) LVLWZCLMPUYAEY-UHFFFAOYSA-N 262561 3-isothiazolo[3,4-b]pyridin-3-yl-2- (1H-tetrazol-5- yl)benzenesulfonamide::US9708336, 413 Metallo-beta-lactamase type 2 340 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262561 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262561&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823609 376224388 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496837 NS(=O)(=O)c1cccc(-c2snc3cccnc23)c1-c1nnn[nH]1 InChI=1S/C13H9N7O2S2/c14-24(21,22)9-5-1-3-7(10(9)13-16-19-20-17-13)12-11-8(18-23-12)4-2-6-15-11/h1-6H,(H2,14,21,22)(H,16,17,19,20) KJXPZMCLMJHEKI-UHFFFAOYSA-N 262562 3-isothiazolo[4,3-b]pyridin-3-yl-2- (1H-tetrazol-5- yl)benzenesulfonamide::US9708336, 414 Metallo-beta-lactamase type 2 177 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262562 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262562&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823610 376224389 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496840 Nc1ccc(-c2cccc(c2-c2nnn[nH]2)S(N)(=O)=O)c2ccncc12 InChI=1S/C16H13N7O2S/c17-13-5-4-9(10-6-7-19-8-12(10)13)11-2-1-3-14(26(18,24)25)15(11)16-20-22-23-21-16/h1-8H,17H2,(H2,18,24,25)(H,20,21,22,23) XWXKHNRXQHEJFH-UHFFFAOYSA-N 262563 3-(8-amino-5-isoquinolyl)-2-(1H- tetrazol-5-yl)benzenesulfonamide::US9708336, 415 Metallo-beta-lactamase type 2 32.3 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262563 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262563&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823611 376224390 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496843 Nc1cnc2cc(ccc2c1)-c1cccc(c1-c1nnn[nH]1)S(N)(=O)=O InChI=1S/C16H13N7O2S/c17-11-6-10-5-4-9(7-13(10)19-8-11)12-2-1-3-14(26(18,24)25)15(12)16-20-22-23-21-16/h1-8H,17H2,(H2,18,24,25)(H,20,21,22,23) WODBGNPBZXCDGC-UHFFFAOYSA-N 262564 3-(3-amino-7-quinolyl)-2-(1H- tetrazol-5- yl)benzenesulfonamide::US9708336, 416 Metallo-beta-lactamase type 2 56.5 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262564 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262564&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823612 376224391 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496846 Nc1nc2ccc(cc2s1)-c1cccc(c1-c1nnn[nH]1)S(N)(=O)=O InChI=1S/C14H11N7O2S2/c15-14-17-9-5-4-7(6-10(9)24-14)8-2-1-3-11(25(16,22)23)12(8)13-18-20-21-19-13/h1-6H,(H2,15,17)(H2,16,22,23)(H,18,19,20,21) CLMDYOPEBQELAK-UHFFFAOYSA-N 262565 3-(2-amino-1,3-benzothiazol-6- yl)-2-(1H-tetrazol-5- yl)benzenesulfonamide::US9708336, 417 Metallo-beta-lactamase type 2 49.8 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262565 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262565&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823613 376224392 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496849 Nc1cccn2c(cnc12)-c1cccc(c1-c1nnn[nH]1)S(N)(=O)=O InChI=1S/C14H12N8O2S/c15-9-4-2-6-22-10(7-17-14(9)22)8-3-1-5-11(25(16,23)24)12(8)13-18-20-21-19-13/h1-7H,15H2,(H2,16,23,24)(H,18,19,20,21) JKUWABLKCGAHNE-UHFFFAOYSA-N 262566 3-(8-aminoimidazo[1,2- a]pyridin-3-yl)-2-(1H-tetrazol- 5-yl)benzenesulfonamide::US9708336, 418 Metallo-beta-lactamase type 2 118 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262566 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262566&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266644 376224393 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496852 NS(=O)(=O)c1cccc(-c2cnc3CCCCn23)c1-c1nnn[nH]1 InChI=1S/C14H15N7O2S/c15-24(22,23)11-5-3-4-9(13(11)14-17-19-20-18-14)10-8-16-12-6-1-2-7-21(10)12/h3-5,8H,1-2,6-7H2,(H2,15,22,23)(H,17,18,19,20) NNEDLGUTQAILED-UHFFFAOYSA-N 262567 3-(5,6,7,8- tetrahydroimidazo[1,2- a]pyridin-3-yl)-2-(1H-tetrazol- 5-yl)benzenesulfonamide::US9708336, 419 Metallo-beta-lactamase type 2 1037 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262567 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262567&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823614 376224394 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496855 Nc1ncc2ccc(cc2n1)-c1cccc(c1-c1nnn[nH]1)S(N)(=O)=O InChI=1S/C15H12N8O2S/c16-15-18-7-9-5-4-8(6-11(9)19-15)10-2-1-3-12(26(17,24)25)13(10)14-20-22-23-21-14/h1-7H,(H2,16,18,19)(H2,17,24,25)(H,20,21,22,23) DFYIOIAAXHRFEI-UHFFFAOYSA-N 262568 3-(2-Aminoquinazolin-7-yl)-2-(1H-tetrazol-5-yl)benzenesulfonamide::US9708336, 420 Metallo-beta-lactamase type 2 217 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262568 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262568&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823615 376224395 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496858 NS(=O)(=O)c1cccc(-c2cccc3sc(Br)nc23)c1-c1nnn[nH]1 InChI=1S/C14H9BrN6O2S2/c15-14-17-12-8(4-1-5-9(12)24-14)7-3-2-6-10(25(16,22)23)11(7)13-18-20-21-19-13/h1-6H,(H2,16,22,23)(H,18,19,20,21) YWSUTBVRJKOSQR-UHFFFAOYSA-N 262569 3-(2-Bromobenzo[d]thiazol-4-yl)-2-(1H-tetrazol-5-yl)benzenesulfonamide::US9708336, 421 Metallo-beta-lactamase type 2 18.8 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262569 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262569&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823616 376224396 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496861 NS(=O)(=O)c1cccc(-c2cccc3scnc23)c1-c1nnn[nH]1 InChI=1S/C14H10N6O2S2/c15-24(21,22)11-6-2-3-8(12(11)14-17-19-20-18-14)9-4-1-5-10-13(9)16-7-23-10/h1-7H,(H2,15,21,22)(H,17,18,19,20) ZZRPLSORSGZNSW-UHFFFAOYSA-N 262570 3-(Benzo[d]thiazol-4-yl)-2-(1H-tetrazol-5-yl)benzenesulfonamide::US9708336, 422 Metallo-beta-lactamase type 2 56.0 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262570 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262570&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823617 376224397 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496864 Nc1nc2c(cccc2s1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)C(F)(F)F InChI=1S/C15H10F3N7O2S2/c16-15(17,18)8-5-4-6(7-2-1-3-9-11(7)21-14(19)28-9)10(12(8)29(20,26)27)13-22-24-25-23-13/h1-5H,(H2,19,21)(H2,20,26,27)(H,22,23,24,25) UKIORIWISGQFSR-UHFFFAOYSA-N 262571 3-(2-amino-1,3-benzothiazol-4-yl)-2-(2H-tetrazol-5-yl)-6-(trifluoromethyl)benzenesulfonamide::US9708336, 423::US9708336, 561 Metallo-beta-lactamase type 2 1.29 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262571 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262571&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118257480 376224398 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496867 Nc1ncc(s1)-c1ccc(Br)c(c1-c1nn[nH]n1)S(N)(=O)=O InChI=1S/C10H8BrN7O2S2/c11-5-2-1-4(6-3-14-10(12)21-6)7(8(5)22(13,19)20)9-15-17-18-16-9/h1-3H,(H2,12,14)(H2,13,19,20)(H,15,16,17,18) KLJFASQFJGWTEL-UHFFFAOYSA-N 262572 3-(2-aminothiazol-5-yl)-6-bromo-2-(2H-tetrazol-5-yl)benzenesulfonamide::US9708336, 424 Metallo-beta-lactamase type 2 80.8 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262572 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262572&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118256989 376224399 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496870 NS(=O)(=O)c1c(Br)ccc(-c2ccc(CNC=N)cc2)c1-c1nn[nH]n1 InChI=1S/C15H14BrN7O2S/c16-12-6-5-11(10-3-1-9(2-4-10)7-19-8-17)13(14(12)26(18,24)25)15-20-22-23-21-15/h1-6,8H,7H2,(H2,17,19)(H2,18,24,25)(H,20,21,22,23) ZBUSBYPPEWBVEZ-UHFFFAOYSA-N 262573 N-((4′-bromo-3′-sulfamoyl-2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)formimidamide::US9708336, 425 Metallo-beta-lactamase type 2 15.9 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262573 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262573&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823618 376224400 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496873 NS(=O)(=O)c1cccc(-c2ccc(NCCO)nc2)c1-c1nn[nH]n1 InChI=1S/C14H15N7O3S/c15-25(23,24)11-3-1-2-10(13(11)14-18-20-21-19-14)9-4-5-12(17-8-9)16-6-7-22/h1-5,8,22H,6-7H2,(H,16,17)(H2,15,23,24)(H,18,19,20,21) FCMHKFPYJSXQEQ-UHFFFAOYSA-N 262574 3-(6-((2-hydroxyethyl)amino)pyridin-3-yl)-2-(2H-tetrazol-5-yl)benzenesulfonamide::BDBM262577::US9708336, 426 Metallo-beta-lactamase type 2 353 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262574 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262574&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823619 376224401 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496876 Nc1ccc(CCc2cccc(c2-c2nn[nH]n2)S(N)(=O)=O)cn1 InChI=1S/C14H15N7O2S/c15-12-7-5-9(8-17-12)4-6-10-2-1-3-11(24(16,22)23)13(10)14-18-20-21-19-14/h1-3,5,7-8H,4,6H2,(H2,15,17)(H2,16,22,23)(H,18,19,20,21) HGIRXMFKQHOMOQ-UHFFFAOYSA-N 262575 3-(2-(6-aminopyridin-3-yl)ethyl)-2-(2H-tetrazol-5-yl)benzenesulfonamide::US9708336, 427 Metallo-beta-lactamase type 2 109 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262575 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262575&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823620 376224402 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497398 NC[C@H]1CC[C@H](Cc2ccc(-c3ccc(cc3)C3CNC3)c(-c3nnn[nH]3)c2S(N)(=O)=O)CC1 262748 4-(((1r,4r)-4- (aminomethyl)cyclohexyl)meth- yl)-4'-(azetidin-3-yl)-2-(1H- tetrazol-5-yl)-[1,1'-biphenyl]-3- sulfonamide::US9708336, 601 Metallo-beta-lactamase type 2 13.1 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262748 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262748&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823677 376224572 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 495838 COc1ccc(cn1)-c1cccc(c1-c1nn[nH]n1)S(N)(=O)=O InChI=1S/C13H12N6O3S/c1-22-11-6-5-8(7-15-11)9-3-2-4-10(23(14,20)21)12(9)13-16-18-19-17-13/h2-7H,1H3,(H2,14,20,21)(H,16,17,18,19) MESZSSFHHIGVGA-UHFFFAOYSA-N 262229 3-(6-methoxypyridin-3-yl)-2- (2H-tetrazol-5- yl)benzenesulfonamide::US9708336, 78 Metallo-beta-lactamase type 2 202 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262229 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262229&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823506 376224057 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 495841 Cc1nc(F)ccc1-c1cccc(c1-c1nn[nH]n1)S(N)(=O)=O InChI=1S/C13H11FN6O2S/c1-7-8(5-6-11(14)16-7)9-3-2-4-10(23(15,21)22)12(9)13-17-19-20-18-13/h2-6H,1H3,(H2,15,21,22)(H,17,18,19,20) UKJMDQYUAPXVLW-UHFFFAOYSA-N 262230 3-(6-fluoro-2-methylpyridin- 3-yl)-2-(2H-tetrazol-5- yl)benzenesulfonamide::US9708336, 79 Metallo-beta-lactamase type 2 3967 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262230 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262230&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823507 376224058 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 495844 NS(=O)(=O)c1cccc(-c2ccc(O)nc2)c1-c1nn[nH]n1 InChI=1S/C12H10N6O3S/c13-22(20,21)9-3-1-2-8(7-4-5-10(19)14-6-7)11(9)12-15-17-18-16-12/h1-6H,(H,14,19)(H2,13,20,21)(H,15,16,17,18) IKFVZDHIEIWFHK-UHFFFAOYSA-N 262231 3-(6-hydroxypyridin-3-yl)-2- (2H-tetrazol-5- yl)benzenesulfonamide::US9708336, 80 Metallo-beta-lactamase type 2 2384 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262231 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262231&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266060 376224059 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 495847 NC(=O)c1cccc(c1)-c1cccc(c1-c1nn[nH]n1)S(N)(=O)=O InChI=1S/C14H12N6O3S/c15-13(21)9-4-1-3-8(7-9)10-5-2-6-11(24(16,22)23)12(10)14-17-19-20-18-14/h1-7H,(H2,15,21)(H2,16,22,23)(H,17,18,19,20) KXEQVZZHYOGVGA-UHFFFAOYSA-N 262232 3'-sulfamoyl-2'-(2H-tetrazol- 5-yl)biphenyl-3-carboxamide::US9708336, 81 Metallo-beta-lactamase type 2 571 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262232 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262232&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266071 376224060 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 495850 CS(=O)(=O)Nc1ccc(cc1)-c1cccc(c1-c1nn[nH]n1)S(N)(=O)=O InChI=1S/C14H14N6O4S2/c1-25(21,22)18-10-7-5-9(6-8-10)11-3-2-4-12(26(15,23)24)13(11)14-16-19-20-17-14/h2-8,18H,1H3,(H2,15,23,24)(H,16,17,19,20) DAQJTKNXRHBHCF-UHFFFAOYSA-N 262233 4'-[(methylsulfonyl)amino]- 2-(2H-tetrazol-5-yl)biphenyl- 3-sulfonamide::US9708336, 82 Metallo-beta-lactamase type 2 22.2 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262233 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262233&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823508 376224061 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 495853 NS(=O)(=O)c1cccc(-c2cncc(F)c2)c1-c1nn[nH]n1 InChI=1S/C12H9FN6O2S/c13-8-4-7(5-15-6-8)9-2-1-3-10(22(14,20)21)11(9)12-16-18-19-17-12/h1-6H,(H2,14,20,21)(H,16,17,18,19) JMRDKQDNBBFYOV-UHFFFAOYSA-N 262234 3-(5-fluoropyridin-3-yl)-2- (2H-tetrazol-5- yl)benzenesulfonamide::US9708336, 83 Metallo-beta-lactamase type 2 520 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262234 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262234&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823509 376224062 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 495856 NS(=O)(=O)c1cccc(-c2ccc3[nH]c(=O)[nH]c3c2)c1-c1nn[nH]n1 InChI=1S/C14H11N7O3S/c15-25(23,24)11-3-1-2-8(12(11)13-18-20-21-19-13)7-4-5-9-10(6-7)17-14(22)16-9/h1-6H,(H2,15,23,24)(H2,16,17,22)(H,18,19,20,21) UWMWKKMMKYXIPW-UHFFFAOYSA-N 262235 3-(2-oxo-2,3-dihydro-1H- benzimidazol-5-yl)-2-(2H- tetrazol-5- yl)benzenesulfonamide::US9708336, 84 Metallo-beta-lactamase type 2 708 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262235 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262235&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823510 376224063 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 495859 NS(=O)(=O)c1cccc(-c2ccc3OCCCc3c2)c1-c1nn[nH]n1 InChI=1S/C16H15N5O3S/c17-25(22,23)14-5-1-4-12(15(14)16-18-20-21-19-16)10-6-7-13-11(9-10)3-2-8-24-13/h1,4-7,9H,2-3,8H2,(H2,17,22,23)(H,18,19,20,21) VOZNXCVRTGVKMT-UHFFFAOYSA-N 262236 3-(3,4-dihydro-2H-chromen- 6-yl)-2-(2H-tetrazol-5- yl)benzenesulfonamide::US9708336, 85 Metallo-beta-lactamase type 2 94.6 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262236 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262236&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823511 376224064 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 495862 CS(=O)(=O)Nc1cccc(c1)-c1cccc(c1-c1nn[nH]n1)S(N)(=O)=O InChI=1S/C14H14N6O4S2/c1-25(21,22)18-10-5-2-4-9(8-10)11-6-3-7-12(26(15,23)24)13(11)14-16-19-20-17-14/h2-8,18H,1H3,(H2,15,23,24)(H,16,17,19,20) XGKPXKILABJNSS-UHFFFAOYSA-N 262237 3'-[(methylsulfonyl)amino]- 2-(2H-tetrazol-5-yl)biphenyl- 3-sulfonamide::US9708336, 86 Metallo-beta-lactamase type 2 67.4 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262237 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262237&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823512 376224065 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 495865 CN(C)CCNC(=O)c1ccc(cc1)-c1cccc(c1-c1nn[nH]n1)S(N)(=O)=O InChI=1S/C18H21N7O3S/c1-25(2)11-10-20-18(26)13-8-6-12(7-9-13)14-4-3-5-15(29(19,27)28)16(14)17-21-23-24-22-17/h3-9H,10-11H2,1-2H3,(H,20,26)(H2,19,27,28)(H,21,22,23,24) NTAYTXHOPMMQHW-UHFFFAOYSA-N 262238 N-[2-(dimethylamino)ethyl]- 3'-sulfamoyl-2'-(2H-tetrazol- 5-yl)biphenyl-4-carboxamide::US9708336, 87 Metallo-beta-lactamase type 2 908 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262238 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262238&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823513 376224066 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 495868 CONC(=O)c1ccc(cc1)-c1cccc(c1-c1nn[nH]n1)S(N)(=O)=O InChI=1S/C15H14N6O4S/c1-25-19-15(22)10-7-5-9(6-8-10)11-3-2-4-12(26(16,23)24)13(11)14-17-20-21-18-14/h2-8H,1H3,(H,19,22)(H2,16,23,24)(H,17,18,20,21) FRNONMTVNXSAGF-UHFFFAOYSA-N 262239 N-methoxy-3'-sulfamoyl-2'- (2H-tetrazol-5-yl)biphenyl-4- carboxamide::US9708336, 88 Metallo-beta-lactamase type 2 87.3 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262239 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262239&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823514 376224067 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 495871 NS(=O)(=O)c1cccc(-c2ccc(OCCN3CCCCC3)cc2)c1-c1nn[nH]n1 InChI=1S/C20H24N6O3S/c21-30(27,28)18-6-4-5-17(19(18)20-22-24-25-23-20)15-7-9-16(10-8-15)29-14-13-26-11-2-1-3-12-26/h4-10H,1-3,11-14H2,(H2,21,27,28)(H,22,23,24,25) YZKAOXFPBLLDNV-UHFFFAOYSA-N 262240 4'-(2-piperidin-1-ylethoxy)- 2-(2H-tetrazol-5-yl)biphen- 3-sulfonamide::US9708336, 89 Metallo-beta-lactamase type 2 319 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262240 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262240&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823515 376224068 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 495874 NS(=O)(=O)c1cccc(-c2ccc3cn[nH]c3c2)c1-c1nn[nH]n1 InChI=1S/C14H11N7O2S/c15-24(22,23)12-3-1-2-10(13(12)14-18-20-21-19-14)8-4-5-9-7-16-17-11(9)6-8/h1-7H,(H,16,17)(H2,15,22,23)(H,18,19,20,21) QUAXLPOWRAQBKR-UHFFFAOYSA-N 262241 3-(1H-indazol-6-yl)-2-(2H- tetrazol-5- yl)benzenesulfonamide::US9708336, 90 Metallo-beta-lactamase type 2 197 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262241 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262241&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266082 376224069 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 495877 COc1ncc(cn1)-c1cccc(c1-c1nn[nH]n1)S(N)(=O)=O InChI=1S/C12H11N7O3S/c1-22-12-14-5-7(6-15-12)8-3-2-4-9(23(13,20)21)10(8)11-16-18-19-17-11/h2-6H,1H3,(H2,13,20,21)(H,16,17,18,19) RPJPTTPMSPDSIM-UHFFFAOYSA-N 262242 3-(2-methoxypyrimidin-5- yl)-2-(2H-tetrazol-5- yl)benzenesulfonamide::US9708336, 91 Metallo-beta-lactamase type 2 830 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262242 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262242&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823516 376224070 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 495880 NS(=O)(=O)c1cccc(-c2ccnc(CO)c2)c1-c1nn[nH]n1 InChI=1S/C13H12N6O3S/c14-23(21,22)11-3-1-2-10(12(11)13-16-18-19-17-13)8-4-5-15-9(6-8)7-20/h1-6,20H,7H2,(H2,14,21,22)(H,16,17,18,19) DOSDOLFANUSZOE-UHFFFAOYSA-N 262243 3-[2- (hydroxymethyl)pyridin-4- yl]-2-(2H-tetrazol-5- yl)benzenesulfonamide::US9708336, 92 Metallo-beta-lactamase type 2 2530 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262243 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262243&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823517 376224071 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 495883 NS(=O)(=O)c1cccc(-c2ccccn2)c1-c1nn[nH]n1 InChI=1S/C12H10N6O2S/c13-21(19,20)10-6-3-4-8(9-5-1-2-7-14-9)11(10)12-15-17-18-16-12/h1-7H,(H2,13,19,20)(H,15,16,17,18) REVHKONLSLUULI-UHFFFAOYSA-N 262244 3-pyridin-2-yl-2-(2H- tetrazol-5- yl)benzenesulfonamide::US9708336, 93 Metallo-beta-lactamase type 2 331 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262244 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262244&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823518 376224072 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 495886 NS(=O)(=O)c1cccc(-c2cnc(nc2)N2CCOCC2)c1-c1nn[nH]n1 InChI=1S/C15H16N8O3S/c16-27(24,25)12-3-1-2-11(13(12)14-19-21-22-20-14)10-8-17-15(18-9-10)23-4-6-26-7-5-23/h1-3,8-9H,4-7H2,(H2,16,24,25)(H,19,20,21,22) QGKUJJICKXDJAR-UHFFFAOYSA-N 262245 3-(2-morpholin-4- ylpyrimidin-5-yl)-2-(2H- tetrazol-5- yl)benzenesulfonamide::US9708336, 94 Metallo-beta-lactamase type 2 164 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262245 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262245&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823519 376224073 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 495889 NS(=O)(=O)c1cccc(-c2ccnn2Cc2ccccc2)c1-c1nn[nH]n1 InChI=1S/C17H15N7O2S/c18-27(25,26)15-8-4-7-13(16(15)17-20-22-23-21-17)14-9-10-19-24(14)11-12-5-2-1-3-6-12/h1-10H,11H2,(H2,18,25,26)(H,20,21,22,23) PTINNZLXBUVPPX-UHFFFAOYSA-N 262246 3-(1-benzyl-1H-pyrazol-5- yl)-2-(2H-tetrazol-5- yl)benzenesulfonamide::US9708336, 95 Metallo-beta-lactamase type 2 534 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262246 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262246&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823520 376224074 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 495892 NS(=O)(=O)c1cccc(-c2csc3ccccc23)c1-c1nn[nH]n1 InChI=1S/C15H11N5O2S2/c16-24(21,22)13-7-3-5-10(14(13)15-17-19-20-18-15)11-8-23-12-6-2-1-4-9(11)12/h1-8H,(H2,16,21,22)(H,17,18,19,20) MPGVGPDREQOUIK-UHFFFAOYSA-N 262247 3-(1-benzothiophen-3-yl)-2- (2H-tetrazol-5- yl)benzenesulfonamide::US9708336, 96 Metallo-beta-lactamase type 2 109 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262247 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262247&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823521 376224075 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 495895 Cn1ccc(n1)-c1cccc(c1-c1nn[nH]n1)S(N)(=O)=O InChI=1S/C11H11N7O2S/c1-18-6-5-8(15-18)7-3-2-4-9(21(12,19)20)10(7)11-13-16-17-14-11/h2-6H,1H3,(H2,12,19,20)(H,13,14,16,17) PLKVAQWXYWOENE-UHFFFAOYSA-N 262248 3-(1-methyl-1H-pyrazol-3- yl)-2-(2H-tetrazol-5- yl)benzenesulfonamide::US9708336, 97 Metallo-beta-lactamase type 2 1572 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262248 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262248&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823522 376224076 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 495898 NS(=O)(=O)c1cccc(-c2cnn3ccccc23)c1-c1nn[nH]n1 InChI=1S/C14H11N7O2S/c15-24(22,23)12-6-3-4-9(13(12)14-17-19-20-18-14)10-8-16-21-7-2-1-5-11(10)21/h1-8H,(H2,15,22,23)(H,17,18,19,20) GELCBGYQYGHJER-UHFFFAOYSA-N 262249 3-pyrazolo[1,5-a]pyridin-3- yl-2-(2H-tetrazol-5- yl)benzenesulfonamide::US9708336, 98 Metallo-beta-lactamase type 2 320 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262249 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262249&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823523 376224077 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 495901 NS(=O)(=O)c1cccc(C2Cc3cc(ccc3N2)C#N)c1-c1nn[nH]n1 262250 3-(5-cyano-1H-indol-2-yl)-2- (2H-tetrazol-5- yl)benzenesulfonamide::US9708336, 99 Metallo-beta-lactamase type 2 208 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262250 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262250&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823524 376224078 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496879 Nc1nc2cccc(-c3cccc(c3-c3nn[nH]n3)S(N)(=O)=O)c2[nH]1 InChI=1S/C14H12N8O2S/c15-14-17-9-5-1-4-8(12(9)18-14)7-3-2-6-10(25(16,23)24)11(7)13-19-21-22-20-13/h1-6H,(H3,15,17,18)(H2,16,23,24)(H,19,20,21,22) WZUQCZVURICHMM-UHFFFAOYSA-N 262576 3-(2-amino-1H-benzo[d]imidazol-7-yl)-2-(2H-tetrazol-5-yl)benzenesulfonamide::US9708336, 428 Metallo-beta-lactamase type 2 345 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262576 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262576&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823621 376224403 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496882 NS(=O)(=O)c1cccc(-c2ccc(NCCO)nc2)c1-c1nn[nH]n1 InChI=1S/C14H15N7O3S/c15-25(23,24)11-3-1-2-10(13(11)14-18-20-21-19-14)9-4-5-12(17-8-9)16-6-7-22/h1-5,8,22H,6-7H2,(H,16,17)(H2,15,23,24)(H,18,19,20,21) FCMHKFPYJSXQEQ-UHFFFAOYSA-N 262574 3-(6-((2-hydroxyethyl)amino)pyridin-3-yl)-2-(2H-tetrazol-5-yl)benzenesulfonamide::BDBM262577::US9708336, 426 Metallo-beta-lactamase type 2 499 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262574 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262574&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823619 376224401 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496885 NS(=O)(=O)c1c(ccc(-c2ccc(cc2)C2CCNCC2)c1-c1nn[nH]n1)-c1ccc(cc1)C1CCNCC1 InChI=1S/C29H33N7O2S/c30-39(37,38)28-26(24-7-3-20(4-8-24)22-13-17-32-18-14-22)10-9-25(27(28)29-33-35-36-34-29)23-5-1-19(2-6-23)21-11-15-31-16-12-21/h1-10,21-22,31-32H,11-18H2,(H2,30,37,38)(H,33,34,35,36) XYDINBKKBOAGNU-UHFFFAOYSA-N 262578 3,6-bis[4-(4-piperidyl)phenyl]-2-(2H-tetrazol-5-yl)benzenesulfonamide::US9708336, 430 Metallo-beta-lactamase type 2 6.38 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262578 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262578&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823622 376224405 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496888 N[C@H]1CC[C@H](CCc2ccc(c(c2-c2nn[nH]n2)S(N)(=O)=O)C(F)(F)F)CC1 262579 3-(2-((1r,4s)-4-aminocyclohexyl)ethyl)-2-(2H-tetrazol-5-yl)-6-(trifluoromethyl)benzenesulfonamide::US9708336, 431 Metallo-beta-lactamase type 2 3.75 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262579 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262579&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266430 376224406 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496891 N[C@H]1CC[C@@H](CCc2ccc(c(c2-c2nn[nH]n2)S(N)(=O)=O)C(F)(F)F)CC1 262580 3-(2-((1s,4r)-4-aminocyclohexyl)ethyl)-2-(2H-tetrazol-5-yl)-6-(trifluoromethyl)benzenesulfonamide::US9708336, 432 Metallo-beta-lactamase type 2 11.7 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262580 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262580&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266430 376224407 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496894 NS(=O)(=O)c1c(ccc(-c2ccc(cc2)C2CNC2)c1-c1nn[nH]n1)C(F)(F)F InChI=1S/C17H15F3N6O2S/c18-17(19,20)13-6-5-12(10-3-1-9(2-4-10)11-7-22-8-11)14(15(13)29(21,27)28)16-23-25-26-24-16/h1-6,11,22H,7-8H2,(H2,21,27,28)(H,23,24,25,26) SKBNRLXMOUEXLT-UHFFFAOYSA-N 262581 4′-(azetidin-3-yl)-2-(2H-tetrazol-5-yl)-4-(trifluoromethyl)-[1,1′-biphenyl]-3-sulfonamide::US9708336, 433 Metallo-beta-lactamase type 2 0.563 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262581 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262581&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823623 376224408 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496897 NC(=N)N1CC(C1)c1ccc(cc1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)C(F)(F)F InChI=1S/C18H17F3N8O2S/c19-18(20,21)13-6-5-12(14(15(13)32(24,30)31)16-25-27-28-26-16)10-3-1-9(2-4-10)11-7-29(8-11)17(22)23/h1-6,11H,7-8H2,(H3,22,23)(H2,24,30,31)(H,25,26,27,28) NEDNPGDOIZXXND-UHFFFAOYSA-N 262582 3-(3′-sulfamoyl-2′-(2H-tetrazol-5-yl)-4′-(trifluoromethyl)-[1,1′-biphenyl]-4-yl)azetidine-1-carboximidamide::US9708336, 434 Metallo-beta-lactamase type 2 1.85 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262582 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262582&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823624 376224409 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496900 C[N]1(C)CC(C1)c1ccc(cc1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)C(F)(F)F InChI=1S/C19H20F3N6O2S/c1-28(2)9-13(10-28)11-3-5-12(6-4-11)14-7-8-15(19(20,21)22)17(31(23,29)30)16(14)18-24-26-27-25-18/h3-8,13H,9-10H2,1-2H3,(H2,23,29,30)(H,24,25,26,27) FNJJAVLINYXVJK-UHFFFAOYSA-N 262583 1,1-dimethyl-3-(3′-sulfamoyl-2′-(2H-tetrazol-5-yl)-4′-(trifluoromethyl)-[1,1′-biphenyl]-4-yl)azetidin-1-ium::US9708336, 435 Metallo-beta-lactamase type 2 11.1 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262583 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262583&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823625 376224410 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496903 NC1(CCNCC1)c1ccc(cc1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)C(F)(F)F InChI=1S/C19H20F3N7O2S/c20-19(21,22)14-6-5-13(15(16(14)32(24,30)31)17-26-28-29-27-17)11-1-3-12(4-2-11)18(23)7-9-25-10-8-18/h1-6,25H,7-10,23H2,(H2,24,30,31)(H,26,27,28,29) MRBGZWNLJOZWRI-UHFFFAOYSA-N 262584 4′-(4-aminopiperidin-4-yl)-2-(2H-tetrazol-5-yl)-4-(trifluoromethyl)-[1,1′-biphenyl]-3-sulfonamide::US9708336, 436 Metallo-beta-lactamase type 2 12.8 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262584 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262584&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823626 376224411 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496906 NC1(CCN(CC1)C=N)c1ccc(cc1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)C(F)(F)F InChI=1S/C20H21F3N8O2S/c21-20(22,23)15-6-5-14(16(17(15)34(26,32)33)18-27-29-30-28-18)12-1-3-13(4-2-12)19(25)7-9-31(11-24)10-8-19/h1-6,11,24H,7-10,25H2,(H2,26,32,33)(H,27,28,29,30) QEKRKNHQVPTRPI-UHFFFAOYSA-N 262585 4′-(4-amino-1-(iminomethyl)piperidin-4-yl)-2-(2H-tetrazol-5-yl)-4-(trifluoromethyl)-[1,1′-biphenyl]-3-sulfonamide::US9708336, 437 Metallo-beta-lactamase type 2 7.82 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262585 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262585&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823627 376224412 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496909 NC(=N)N1CCC(N)(CC1)c1ccc(cc1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)C(F)(F)F InChI=1S/C20H22F3N9O2S/c21-20(22,23)14-6-5-13(15(16(14)35(27,33)34)17-28-30-31-29-17)11-1-3-12(4-2-11)19(26)7-9-32(10-8-19)18(24)25/h1-6H,7-10,26H2,(H3,24,25)(H2,27,33,34)(H,28,29,30,31) GQLKUAOPXIPOEB-UHFFFAOYSA-N 262586 4-amino-4-(3′-sulfamoyl-2′-(2H-tetrazol-5-yl)-4′-(trifluoromethyl)-[1,1′-biphenyl]-4-yl)piperidine-1-carboximidamide::US9708336, 438 Metallo-beta-lactamase type 2 4.05 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262586 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262586&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823628 376224413 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496912 NCc1ccc(cc1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)C(F)(F)F InChI=1S/C15H13F3N6O2S/c16-15(17,18)11-6-5-10(9-3-1-8(7-19)2-4-9)12(13(11)27(20,25)26)14-21-23-24-22-14/h1-6H,7,19H2,(H2,20,25,26)(H,21,22,23,24) LVRBIIZYISHPIX-UHFFFAOYSA-N 262587 4′-(aminomethyl)-2-(2H-tetrazol-5-yl)-4-(trifluoromethyl)-[1,1′-biphenyl]-3-sulfonamide::US9708336, 439 Metallo-beta-lactamase type 2 20.6 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262587 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262587&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823629 376224414 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496915 NC(=N)NCc1ccc(cc1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)C(F)(F)F InChI=1S/C16H15F3N8O2S/c17-16(18,19)11-6-5-10(9-3-1-8(2-4-9)7-23-15(20)21)12(13(11)30(22,28)29)14-24-26-27-25-14/h1-6H,7H2,(H4,20,21,23)(H2,22,28,29)(H,24,25,26,27) FUCYUBZRPKYLIY-UHFFFAOYSA-N 262588 4′-(guanidinomethyl)-2-(2H-tetrazol-5-yl)-4-(trifluoromethyl)-[1,1′-biphenyl]-3-sulfonamide::US9708336, 440 Metallo-beta-lactamase type 2 3.37 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262588 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262588&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823630 376224415 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496918 NS(=O)(=O)c1c(ccc(-c2ccc3CNCc3c2)c1-c1nn[nH]n1)C(F)(F)F InChI=1S/C16H13F3N6O2S/c17-16(18,19)12-4-3-11(8-1-2-9-6-21-7-10(9)5-8)13(14(12)28(20,26)27)15-22-24-25-23-15/h1-5,21H,6-7H2,(H2,20,26,27)(H,22,23,24,25) UZENRFZKKXIQIV-UHFFFAOYSA-N 262589 3-(isoindolin-5-yl)-2-(2H-tetrazol-5-yl)-6- (trifluoromethyl)benzenesulfonamide::US9708336, 441 Metallo-beta-lactamase type 2 22.1 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262589 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262589&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266379 376224416 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496921 NC1Cc2ccc(cc2C1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)C(F)(F)F 262590 3-(2-amino-2,3-dihydro-1H-inden-5-yl)-2-(2H- tetrazol-5-yl)-6- (trifluoromethyl)benzenesulfonamide::US9708336, 442 Metallo-beta-lactamase type 2 16.5 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262590 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262590&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266558 376224417 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496924 NS(=O)(=O)c1c(ccc(-c2ccc(cc2)C2CCNC2)c1-c1nn[nH]n1)C(F)(F)F 262591 4′-(pyrrolidin-3-yl)-2-(2H-tetrazol-5-yl)-4- (trifluoromethyl)-[1,1′-biphenyl]-3-sulfonamide::US9708336, 443 Metallo-beta-lactamase type 2 1.34 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262591 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262591&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266559 376224418 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496927 C[N+]1(C)CCC(C1)c1ccc(cc1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)C(F)(F)F 262592 1,1-dimethyl-3-(3′-sulfamoyl-2′-(2H-tetrazol-5- yl)-4′-(trifluoromethyl)-[1,1′-biphenyl]-4- yl)pyrrolidin-1-ium::US9708336, 444 Metallo-beta-lactamase type 2 3.27 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262592 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262592&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266636 376224419 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496930 NS(=O)(=O)c1c(ccc(-c2ccc(CO)cc2)c1-c1nn[nH]n1)C(F)(F)F InChI=1S/C15H12F3N5O3S/c16-15(17,18)11-6-5-10(9-3-1-8(7-24)2-4-9)12(13(11)27(19,25)26)14-20-22-23-21-14/h1-6,24H,7H2,(H2,19,25,26)(H,20,21,22,23) HVZPFHHNBPQGFF-UHFFFAOYSA-N 262593 4′-(hydroxymethyl)-2-(2H-tetrazol-5-yl)-4- (trifluoromethyl)-[1,1′-biphenyl]-3-sulfonamide::US9708336, 445 Metallo-beta-lactamase type 2 1.17 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262593 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262593&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266637 376224420 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496933 NC(=N)N1Cc2ccc(cc2C1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)C(F)(F)F InChI=1S/C17H15F3N8O2S/c18-17(19,20)12-4-3-11(13(14(12)31(23,29)30)15-24-26-27-25-15)8-1-2-9-6-28(16(21)22)7-10(9)5-8/h1-5H,6-7H2,(H3,21,22)(H2,23,29,30)(H,24,25,26,27) QNNBOLUFWOSFEP-UHFFFAOYSA-N 262594 5-(3-sulfamoyl-2-(2H-tetrazol-5-yl)-4- (trifluoromethyl)phenyl)isoindoline-2- carboximidamide::US9708336, 446 Metallo-beta-lactamase type 2 19.4 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262594 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262594&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266639 376224421 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496936 NC(=N)NC1Cc2ccc(cc2C1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)C(F)(F)F 262595 3-(2-guanidino-2,3-dihydro-1H-inden-5- yl)-2-(2H-tetrazol-5-yl)-6- (trifluoromethyl)benzenesulfonamide::US9708336, 447 Metallo-beta-lactamase type 2 4.26 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262595 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262595&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266640 376224422 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 496939 NC(=O)Cc1ccc(cc1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)C(F)(F)F InChI=1S/C16H13F3N6O3S/c17-16(18,19)11-6-5-10(9-3-1-8(2-4-9)7-12(20)26)13(14(11)29(21,27)28)15-22-24-25-23-15/h1-6H,7H2,(H2,20,26)(H2,21,27,28)(H,22,23,24,25) VDLHSXYZTFDHGY-UHFFFAOYSA-N 262596 2-(3′-sulfamoyl-2′-(2H-tetrazol-5-yl)-4′-(trifluoromethyl)-[1,1′-biphenyl]-4-yl)acetamide::US9708336, 448 Metallo-beta-lactamase type 2 2.17 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262596 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262596&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823631 376224423 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497401 NC[C@H]1CC[C@@H](Cc2ccc(-c3ccc(cc3)C3CNC3)c(-c3nnn[nH]3)c2S(N)(=O)=O)CC1 262749 4-(((1s,4s)-4- (aminomethyl)cyclohexyl)meth- yl)-4'-(azetidin-3-yl)-2-(1H- tetrazol-5-yl)-[1,1'-biphenyl]-3- sulfonamide::US9708336, 602 Metallo-beta-lactamase type 2 21.0 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262749 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262749&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 134823677 376224573 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497404 NC(=N)N1CC(C1)c1ccc(cc1)-c1ccc(CC2CCNCC2)c(c1-c1nn[nH]n1)S(N)(=O)=O InChI=1S/C23H29N9O2S/c24-23(25)32-12-18(13-32)15-1-3-16(4-2-15)19-6-5-17(11-14-7-9-27-10-8-14)21(35(26,33)34)20(19)22-28-30-31-29-22/h1-6,14,18,27H,7-13H2,(H3,24,25)(H2,26,33,34)(H,28,29,30,31) FEAGYJCPTPFCNN-UHFFFAOYSA-N 262750 3-[4-[4-(4-piperidylmethyl)-3-sulfamoyl-2-(2H-tetrazol-5-yl)phenyl]phenyl]azetidine-1-carboxamidine::US9708336, 603 Metallo-beta-lactamase type 2 31.9 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262750 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262750&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118256902 376224574 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497407 NC(=N)N1CCC(Cc2ccc(-c3ccc(cc3)C3CNC3)c(-c3nn[nH]n3)c2S(N)(=O)=O)CC1 InChI=1S/C23H29N9O2S/c24-23(25)32-9-7-14(8-10-32)11-17-5-6-19(16-3-1-15(2-4-16)18-12-27-13-18)20(21(17)35(26,33)34)22-28-30-31-29-22/h1-6,14,18,27H,7-13H2,(H3,24,25)(H2,26,33,34)(H,28,29,30,31) SDUQTYDRBLUCPP-UHFFFAOYSA-N 262751 4-[[4-[4-(azetidin-3-yl)phenyl]-2-sulfamoyl-3-(2H-tetrazol-5-yl)phenyl]methyl]piperidine-1-carboxamidine::US9708336, 604 Metallo-beta-lactamase type 2 41.7 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262751 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262751&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118257216 376224575 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497410 C[N]1(C)CCC(Cc2ccc(-c3ccc(cc3)C3CNC3)c(-c3nn[nH]n3)c2S(N)(=O)=O)CC1 InChI=1S/C24H32N7O2S/c1-31(2)11-9-16(10-12-31)13-19-7-8-21(18-5-3-17(4-6-18)20-14-26-15-20)22(23(19)34(25,32)33)24-27-29-30-28-24/h3-8,16,20,26H,9-15H2,1-2H3,(H2,25,32,33)(H,27,28,29,30) PIEDBWUACRDJHL-UHFFFAOYSA-N 262752 3-[4-(azetidin-3-yl)phenyl]-6-[(1,1-dimethylpiperidin-1-ium-4-yl)methyl]-2-(2H-tetrazol-5-yl)benzenesulfonamide::US9708336, 605 Metallo-beta-lactamase type 2 160 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262752 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262752&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118257018 376224576 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497413 NCCN1CCC(Cc2ccc(-c3ccc(cc3)C3CNC3)c(-c3nn[nH]n3)c2S(N)(=O)=O)CC1 InChI=1S/C24H32N8O2S/c25-9-12-32-10-7-16(8-11-32)13-19-5-6-21(18-3-1-17(2-4-18)20-14-27-15-20)22(23(19)35(26,33)34)24-28-30-31-29-24/h1-6,16,20,27H,7-15,25H2,(H2,26,33,34)(H,28,29,30,31) LPDJFFPREUZXFM-UHFFFAOYSA-N 262753 6-[[1-(2-aminoethyl)-4-piperidyl]methyl]-3-[4-(azetidin-3-yl)phenyl]-2-(2H-tetrazol-5-yl)benzenesulfonamide::US9708336, 606 Metallo-beta-lactamase type 2 51.4 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262753 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262753&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118257173 376224577 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497416 NS(=O)(=O)c1c(CC2CCN(CCO)CC2)ccc(-c2ccc(cc2)C2CNC2)c1-c1nn[nH]n1 InChI=1S/C24H31N7O3S/c25-35(33,34)23-19(13-16-7-9-31(10-8-16)11-12-32)5-6-21(22(23)24-27-29-30-28-24)18-3-1-17(2-4-18)20-14-26-15-20/h1-6,16,20,26,32H,7-15H2,(H2,25,33,34)(H,27,28,29,30) NCILCHIDLXJUBL-UHFFFAOYSA-N 262754 3-[4-(azetidin-3-yl)phenyl]-6-[[1-(2-hydroxyethyl)-4-piperidyl]methyl]-2-(2H-tetrazol-5-yl)benzenesulfonamide::US9708336, 607 Metallo-beta-lactamase type 2 42.2 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262754 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262754&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118257010 376224578 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497419 NS(=O)(=O)c1c(CC2CCNCC2)ccc(-c2ccc(cc2)C2CN(CCO)C2)c1-c1nn[nH]n1 InChI=1S/C24H31N7O3S/c25-35(33,34)23-19(13-16-7-9-26-10-8-16)5-6-21(22(23)24-27-29-30-28-24)18-3-1-17(2-4-18)20-14-31(15-20)11-12-32/h1-6,16,20,26,32H,7-15H2,(H2,25,33,34)(H,27,28,29,30) YVGNXURCCQHBHQ-UHFFFAOYSA-N 262755 3-[4-[1-(2-hydroxyethyl)azetidin-3-yl]phenyl]-6-(4-piperidylmethyl)-2-(2H-tetrazol-5-yl)benzenesulfonamide::US9708336, 608 Metallo-beta-lactamase type 2 127 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262755 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262755&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118256966 376224579 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497422 NC(=O)CN1CCC(Cc2ccc(-c3ccc(cc3)C3CNC3)c(-c3nn[nH]n3)c2S(N)(=O)=O)CC1 InChI=1S/C24H30N8O3S/c25-21(33)14-32-9-7-15(8-10-32)11-18-5-6-20(17-3-1-16(2-4-17)19-12-27-13-19)22(23(18)36(26,34)35)24-28-30-31-29-24/h1-6,15,19,27H,7-14H2,(H2,25,33)(H2,26,34,35)(H,28,29,30,31) VJSGFUFLXAOILP-UHFFFAOYSA-N 262756 2-[4-[[4-[4-(azetidin-3-yl)phenyl]-2-sulfamoyl-3-(2H-tetrazol-5-yl)phenyl]methyl]-1-piperidyl]acetamide::US9708336, 609 Metallo-beta-lactamase type 2 83.9 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262756 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262756&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118256821 376224580 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497425 Nc1nc2ccc(cc2[nH]1)-c1ccc(CC2CCNCC2)c(c1-c1nn[nH]n1)S(N)(=O)=O InChI=1S/C20H23N9O2S/c21-20-24-15-4-2-12(10-16(15)25-20)14-3-1-13(9-11-5-7-23-8-6-11)18(32(22,30)31)17(14)19-26-28-29-27-19/h1-4,10-11,23H,5-9H2,(H3,21,24,25)(H2,22,30,31)(H,26,27,28,29) YILYSGVWIJYJKB-UHFFFAOYSA-N 262757 3-(2-amino-3H-benzo[d]imidazol-5-yl)-6-(piperidin-4-ylmethyl)-2-(2H-tetrazol-5-yl)benzenesulfonamide::US9708336, 610 Metallo-beta-lactamase type 2 114 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262757 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262757&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118256854 376224581 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497428 Nc1nc2cc(ccc2[nH]1)-c1ccc(CC2CNC2)c(c1-c1nn[nH]n1)S(N)(=O)=O InChI=1S/C18H19N9O2S/c19-18-22-13-4-2-10(6-14(13)23-18)12-3-1-11(5-9-7-21-8-9)16(30(20,28)29)15(12)17-24-26-27-25-17/h1-4,6,9,21H,5,7-8H2,(H3,19,22,23)(H2,20,28,29)(H,24,25,26,27) ZAUALDSOZCKQRJ-UHFFFAOYSA-N 262758 3-(2-amino-3H-benzo[d]imidazol-5-yl)-6-(azetidin-3-ylmethyl)-2-(2H-tetrazol-5-yl)benzenesulfonamide::US9708336, 611 Metallo-beta-lactamase type 2 344 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262758 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262758&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118257128 376224582 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497431 Nc1nc2cccc(-c3ccc(CC4CCNCC4)c(c3-c3nn[nH]n3)S(N)(=O)=O)c2[nH]1 InChI=1S/C20H23N9O2S/c21-20-24-15-3-1-2-14(17(15)25-20)13-5-4-12(10-11-6-8-23-9-7-11)18(32(22,30)31)16(13)19-26-28-29-27-19/h1-5,11,23H,6-10H2,(H3,21,24,25)(H2,22,30,31)(H,26,27,28,29) QZSIFDHWDRGLTG-UHFFFAOYSA-N 262759 3-(2-amino-3H-benzo[d]imidazol-4-yl)-6-(piperidin-4-ylmethyl)-2-(2H-tetrazol-5-yl)benzenesulfonamide::US9708336, 612 Metallo-beta-lactamase type 2 65.5 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262759 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262759&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118256998 376224583 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497434 NCCCN1CCC(CC1)c1ccc(cc1)-c1cccc(c1-c1nnn[nH]1)S(N)(=O)=O InChI=1S/C21H27N7O2S/c22-11-2-12-28-13-9-16(10-14-28)15-5-7-17(8-6-15)18-3-1-4-19(31(23,29)30)20(18)21-24-26-27-25-21/h1,3-8,16H,2,9-14,22H2,(H2,23,29,30)(H,24,25,26,27) GNKYWZUVRLGHPB-UHFFFAOYSA-N 262760 3-[4-[1-(3-aminopropyl)-4- piperidyl]phenyl]-2-(1H- tetrazol-5- yl)benzenesulfonamide::US9708336, 613 Metallo-beta-lactamase type 2 36.3 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262760 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262760&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266569 376224584 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497437 CC(C)[C@@H](N)CN1CCC(CC1)c1ccc(cc1)-c1cccc(c1-c1nnn[nH]1)S(N)(=O)=O 262761 3-[4-[1-[(2R)-2-amino-3- methyl-butyl]-4- piperidyl]phenyl]-2-(1H- tetrazol-5- yl)benzenesulfonamide::US9708336, 614 Metallo-beta-lactamase type 2 11.6 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262761 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262761&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266570 376224585 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497440 CC(C)[C@H](N)CN1CCC(CC1)c1ccc(cc1)-c1cccc(c1-c1nnn[nH]1)S(N)(=O)=O 262762 3-[4-[1-[(2S)-2-amino-3- methyl-butyl]-4- piperidyl]phenyl]-2-(1H- tetrazol-5- yl)benzenesulfonamide::US9708336, 615 Metallo-beta-lactamase type 2 16.7 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262762 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262762&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266571 376224586 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497443 NCCN1CCC(CC1)c1ccc(cc1)-c1cccc(c1-c1nnn[nH]1)S(N)(=O)=O InChI=1S/C20H25N7O2S/c21-10-13-27-11-8-15(9-12-27)14-4-6-16(7-5-14)17-2-1-3-18(30(22,28)29)19(17)20-23-25-26-24-20/h1-7,15H,8-13,21H2,(H2,22,28,29)(H,23,24,25,26) LSTJRIHYUWQXEF-UHFFFAOYSA-N 262763 3-[4-[1-(2-aminoethyl)-4- piperidyl]phenyl]-2-(1H- tetrazol-5- yl)benzenesulfonamide::US9708336, 616 Metallo-beta-lactamase type 2 14.4 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262763 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262763&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266572 376224587 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497446 NS(=O)(=O)c1cccc(-c2ccc(cc2)C2CCN(CC3CNC3)CC2)c1-c1nnn[nH]1 InChI=1S/C22H27N7O2S/c23-32(30,31)20-3-1-2-19(21(20)22-25-27-28-26-22)18-6-4-16(5-7-18)17-8-10-29(11-9-17)14-15-12-24-13-15/h1-7,15,17,24H,8-14H2,(H2,23,30,31)(H,25,26,27,28) YSZRAIZIYIHTGR-UHFFFAOYSA-N 262764 3-[4-[1-(azetidin-3- ylmethyl)-4- piperidyl]phenyl]-2-(1H- tetrazol-5- yl)benzenesulfonamide::US9708336, 617 Metallo-beta-lactamase type 2 9.66 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262764 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262764&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266568 376224588 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497449 NS(=O)(=O)c1cccc(-c2ccc(cc2)C2CCN(CC3CCNC3)CC2)c1-c1nnn[nH]1 262765 3-[4-[1-(pyrrolidin-3- ylmethyl)-4- piperidyl]phenyl]-2-(1H- tetrazol-5- yl)benzenesulfonamide::US9708336, 618 Metallo-beta-lactamase type 2 16.1 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262765 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262765&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266567 376224589 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497452 NS(=O)(=O)c1cccc(-c2ccc(cc2)C2CCN(C[C@H]3CNCCO3)CC2)c1-c1nnn[nH]1 262766 3-[4-[1-[(2R)-morpholin-2- yl]methyl]-4- piperidyl]phenyl]-2-(1H- tetrazol-5- yl)benzenesulfonamide::US9708336, 619 Metallo-beta-lactamase type 2 10.8 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262766 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262766&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266012 376224590 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497455 Cn1cncc1CN1CCC(CC1)c1ccc(cc1)-c1cccc(c1-c1nnn[nH]1)S(N)(=O)=O InChI=1S/C23H26N8O2S/c1-30-15-25-13-19(30)14-31-11-9-17(10-12-31)16-5-7-18(8-6-16)20-3-2-4-21(34(24,32)33)22(20)23-26-28-29-27-23/h2-8,13,15,17H,9-12,14H2,1H3,(H2,24,32,33)(H,26,27,28,29) RLZOHODUDHXSQG-UHFFFAOYSA-N 262767 3-[4-[1-[(3-methylimidazol- 4-yl)methyl]-4- piperidyl]phenyl]-2-(1H- tetrazol-5- yl)benzenesulfonamide::US9708336, 620 Metallo-beta-lactamase type 2 8.36 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262767 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262767&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266015 376224591 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497458 Cn1ccnc1CN1CCC(CC1)c1ccc(cc1)-c1cccc(c1-c1nnn[nH]1)S(N)(=O)=O InChI=1S/C23H26N8O2S/c1-30-14-11-25-21(30)15-31-12-9-17(10-13-31)16-5-7-18(8-6-16)19-3-2-4-20(34(24,32)33)22(19)23-26-28-29-27-23/h2-8,11,14,17H,9-10,12-13,15H2,1H3,(H2,24,32,33)(H,26,27,28,29) QKCMWQVEMUOSOT-UHFFFAOYSA-N 262768 3-[4-[1-[(1-methylimidazol- 2-yl)methyl]-4- piperidyl]phenyl]-2-(1H- tetrazol-5- yl)benzenesulfonamide::US9708336, 621 Metallo-beta-lactamase type 2 6.02 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262768 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262768&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266687 376224592 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 497461 NS(=O)(=O)c1cccc(-c2ccc(nc2)N2CCC(CO)C2)c1-c1nnn[nH]1 262769 3-[6-[3- (hydroxymethyl)pyrrolidin-1- yl]-3-pyridyl]-2-(1H-tetrazol- 5-yl)benzenesulfonamide::US9708336, 622 Metallo-beta-lactamase type 2 85.6 7 US Patent 10.7270/Q2FN186K aid1795224 US9708336 Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=262769 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=262769&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 118266574 376224593 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727399 NCCS(=O)(=O)c1ccc(-c2cccc(c2)-c2c[nH]c(N)n2)c(-c2nnn[nH]2)c1S(N)(=O)=O InChI=1S/C18H19N9O4S2/c19-6-7-32(28,29)14-5-4-12(15(16(14)33(21,30)31)17-24-26-27-25-17)10-2-1-3-11(8-10)13-9-22-18(20)23-13/h1-5,8-9H,6-7,19H2,(H3,20,22,23)(H2,21,30,31)(H,24,25,26,27) FGPJXURULNTCGK-UHFFFAOYSA-N 368159 3′-(2-Amino-1H-imidazol-4-yl)-4-((2-aminoethyl)sulfonyl)-2-(1H-tetrazol-5-yl)-[1,1′-biphenyl]-3-sulfonamide::US10227331, Example 346 Metallo-beta-lactamase type 2 1.97 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368159 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368159&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 145713752 402365009 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727402 NCCS(=O)(=O)c1ccc(-c2cccc3C(O)C(=O)Nc23)c(-c2nnn[nH]2)c1S(N)(=O)=O 368160 6-((2-Aminoethyl)sulfonyl)-3-(3-hydroxy-2-oxoindolin-7-yl)-2-(1H-tetrazol-5-yl)benzenesulfonamide::US10227331, Example 347 Metallo-beta-lactamase type 2 1.34 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368160 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368160&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124157435 402365010 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727405 C[C@@H](N)CS(=O)(=O)c1ccc(-c2cccc3[nH]c(nc23)C(O)=O)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C18H16N8O6S2/c1-8(19)7-33(29,30)12-6-5-9(13(15(12)34(20,31)32)16-23-25-26-24-16)10-3-2-4-11-14(10)22-17(21-11)18(27)28/h2-6,8H,7,19H2,1H3,(H,27,28)(H2,20,31,32)/b10-9+/t8-/m1/s1 VEDGMINPDLTVAB-KGSKPCQNSA-N 368161 Ammonium (R)-4-(4-((2-aminopropyl)sulfonyl)-3-sulfamoyl-2-(2H-tetrazol-5-yl) phenyl)-1H-benzo[d]imidazole-2-carboxylate::US10227331, Example 348 Metallo-beta-lactamase type 2 0.847 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368161 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368161&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124157538 402365011 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727408 Nc1nc2c(cccc2s1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)[C@@H]1CN[C@H](CO)C1 368162 3-(2-Aminobenzo[d]thiazol-4-yl)-6-(((3 S,5S)-5-(hydroxymethyl)pyrrolidin-3-yl) sulfonyl)-2-(2H-tetrazol-5-yl)benzenesulfonamide::US10227331, Example 349 Metallo-beta-lactamase type 2 0.220 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368162 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368162&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135150121 402365012 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726403 Nc1nc2cccc(-c3ccc(c(c3-c3nn[nH]n3)S(N)(=O)=O)S(=O)C3CCNCC3)c2[nH]1 InChI=1S/C19H19N9O3S2/c20-19-23-13-3-1-2-12(16(13)24-19)11-4-5-14(32(29)10-6-8-22-9-7-10)17(33(21,30)31)15(11)18-25-27-28-26-18/h1-5,10,22H,6-9H2,(H2,20,23)(H2,21,30,31)/b12-11+ RCWFPGXNUWKZGH-VAWYXSNFSA-N 367827 3-(2-amino-3H-benzo[d]imidazol-4-yl)-6-(piperidin-4-ylsulfinyl)-2-(2H-tetrazol-5-yl)benzenesulfonamide::US10227331, Example 14 Metallo-beta-lactamase type 2 23.9 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367827 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367827&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 145713649 402364687 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726406 Cc1ccc(-c2ccc(c(c2-c2nn[nH]n2)S(N)(=O)=O)S(=O)(=O)C2CNC2)c2nc(N)[nH]c12 InChI=1S/C18H19N9O4S2/c1-8-2-3-11(15-14(8)22-18(19)23-15)10-4-5-12(32(28,29)9-6-21-7-9)16(33(20,30)31)13(10)17-24-26-27-25-17/h2-5,9,21H,6-7H2,1H3,(H3,19,22,23)(H2,20,30,31)(H,24,25,26,27) XVJZVEIIIKYRNV-UHFFFAOYSA-N 367828 3-(2-Amino-7-methyl-1H-benzo[d]imidazol-4-yl)-6-(azetidin-3-ylsulfonyl)-2-(2H-tetrazol-5-yl)benzenesulfonamide::US10227331, Example 15 Metallo-beta-lactamase type 2 0.613 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367828 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367828&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 145713650 402364688 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726409 NS(=O)(=O)c1c(ccc(-c2cnc3cc[nH]c3c2)c1-c1nn[nH]n1)S(=O)(=O)C1CNC1 InChI=1S/C17H16N8O4S2/c18-31(28,29)16-14(30(26,27)10-7-19-8-10)2-1-11(15(16)17-22-24-25-23-17)9-5-13-12(21-6-9)3-4-20-13/h1-6,10,19-20H,7-8H2,(H2,18,28,29)(H,22,23,24,25) MBRVOSZLCAZETN-UHFFFAOYSA-N 367829 6-(Azetidin-3-ylsulfonyl)-3-(1H-pyrrolo[3,2-b]pyridin-6-yl)-2-(2H-tetrazol-5-yl)benzenesulfonamide::US10227331, Example 16 Metallo-beta-lactamase type 2 2.37 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367829 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367829&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 145713651 402364689 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726412 Nc1ccc2ncc(-c3ccc(c(c3-c3nn[nH]n3)S(N)(=O)=O)S(=O)(=O)C3CNC3)n2n1 InChI=1S/C16H16N10O4S2/c17-12-3-4-13-20-7-10(26(13)23-12)9-1-2-11(31(27,28)8-5-19-6-8)15(32(18,29)30)14(9)16-21-24-25-22-16/h1-4,7-8,19H,5-6H2,(H2,17,23)(H2,18,29,30)(H,21,22,24,25) JUCUOMCSSPZOOB-UHFFFAOYSA-N 367830 3-(6-Aminoimidazo[1,2-b]pyridazin-3-yl)-6-(azetidin-3-ylsulfonyl)-2-(2H-tetrazol-5-yl)benzenesulfonamide::US10227331, Example 17 Metallo-beta-lactamase type 2 0.959 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367830 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367830&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 145713652 402364690 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726415 NCCS(=O)(=O)c1ccc(-c2cccc3n(CC(F)(F)F)c(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C18H18F3N9O4S2/c19-18(20,21)8-30-11-3-1-2-10(14(11)25-17(30)23)9-4-5-12(35(31,32)7-6-22)15(36(24,33)34)13(9)16-26-28-29-27-16/h1-5H,6-8,22H2,(H2,23,25)(H2,24,33,34)(H,26,27,28,29) KXKCDCDMBHFMSS-UHFFFAOYSA-N 367831 3-(2-Amino-1-(2,2,2-trifluoroethyl)-1H-benzo[d]imidazol-4-yl)-6-((2-aminoethyl)sulfonyl)-2-(2H-tetrazol-5-yl)benzenesulfonamide::US10227331, Example 18 Metallo-beta-lactamase type 2 0.227 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367831 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367831&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 145713653 402364691 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726643 CC(C)(N)CS(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C18H20N8O4S3/c1-18(2,20)8-32(27,28)12-7-6-9(10-4-3-5-11-14(10)22-17(19)31-11)13(15(12)33(21,29)30)16-23-25-26-24-16/h3-7H,8,20H2,1-2H3,(H2,19,22)(H2,21,29,30)(H,23,24,25,26) JJGQKQQHLCIDSM-UHFFFAOYSA-N 367907 6-(2-amino-2-methylpropylsulfonyl)-3-(2-aminobenzo[d]thiazol-4-yl)-2-(2H-tetrazol-5-yl)benzenesulfonamide::US10227331, Example 94 Metallo-beta-lactamase type 2 0.504 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367907 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367907&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135149856 402364767 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726646 Nc1nc2c(cccc2s1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)CC1(N)CC1 InChI=1S/C18H18N8O4S3/c19-17-22-14-10(2-1-3-11(14)31-17)9-4-5-12(32(27,28)8-18(20)6-7-18)15(33(21,29)30)13(9)16-23-25-26-24-16/h1-5H,6-8,20H2,(H2,19,22)(H2,21,29,30)(H,23,24,25,26) XHLFCHURNNNRAL-UHFFFAOYSA-N 367908 3-(2-aminobenzo[d]thiazol-4-yl)-6-((1-aminocyclopropyl)methylsulfonyl)-2-(2H-tetrazol-5-yl)benzenesulfonamide::US10227331, Example 95 Metallo-beta-lactamase type 2 0.221 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367908 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367908&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135149627 402364768 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726649 NC(CO)CS(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O 367909 6-(2-amino-3-hydroxypropylsulfonyl)-3-(2-aminobenzo[d]thiazol-4-yl)-2-(2H-tetrazol-5-yl)benzenesulfonamide::US10227331, Example 96 Metallo-beta-lactamase type 2 0.265 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367909 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367909&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135149725 402364769 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726652 NCC(O)CS(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O 367910 6-(3-amino-2-hydroxypropylsulfonyl)-3-(2-aminobenzo[d]thiazol-4-yl)-2-(2H-tetrazol-5-yl)benzenesulfonamide::US10227331, Example 97 Metallo-beta-lactamase type 2 0.171 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367910 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367910&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135149651 402364770 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726655 NS(=O)(=O)c1c(ccc(-c2cnc3ccccc3c2)c1-c1nnn[nH]1)S(=O)(=O)C1CNC1 InChI=1S/C19H17N7O4S2/c20-32(29,30)18-16(31(27,28)13-9-21-10-13)6-5-14(17(18)19-23-25-26-24-19)12-7-11-3-1-2-4-15(11)22-8-12/h1-8,13,21H,9-10H2,(H2,20,29,30)(H,23,24,25,26) LUEOTGSHQJYZFJ-UHFFFAOYSA-N 367911 3-((4-(quinolin-3-yl)-2- sulfamoyl-3-(1H- tetrazol-5- yl)phenyl)sulfonyl) azetidin-1-ium 2,2,2- trifluoroacetate::US10227331, Example 98 Metallo-beta-lactamase type 2 1.97 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367911 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367911&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135150181 402364771 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726841 Cn1ncc2cc(ccc12)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)CCN InChI=1S/C17H18N8O4S2/c1-25-13-4-2-10(8-11(13)9-20-25)12-3-5-14(30(26,27)7-6-18)16(31(19,28)29)15(12)17-21-23-24-22-17/h2-5,8-9H,6-7,18H2,1H3,(H2,19,28,29)(H,21,22,23,24) FWGXQDKRNBTRTP-UHFFFAOYSA-N 367973 2-((4-(1-methyl-1H- indazol-5-yl)-2- sulfamoyl-3-(1H- tetrazol-5- yl)phenyl)sulfonyl) ethanaminium 2,2,2- trifluoroacetate::US10227331, Example 160 Metallo-beta-lactamase type 2 0.568 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367973 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367973&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135150287 402364833 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726844 NCCS(=O)(=O)c1ccc(-c2cccc(c2)S(=O)(=O)NC2CC2)c(-c2nnn[nH]2)c1S(N)(=O)=O InChI=1S/C18H21N7O6S3/c19-8-9-32(26,27)15-7-6-14(16(17(15)33(20,28)29)18-21-24-25-22-18)11-2-1-3-13(10-11)34(30,31)23-12-4-5-12/h1-3,6-7,10,12,23H,4-5,8-9,19H2,(H2,20,28,29)(H,21,22,24,25) OMTVJRAQCVDYPS-UHFFFAOYSA-N 367974 2-((3'-(N- cyclopropylsulfamoyl)- 3-sulfamoyl-2-(1H- tetrazol-5-yl)-[1,1'- biphenyl]-4- yl)sulfonyl) ethanaminium 2,2,2- trifluoroacetate::US10227331, Example 161 Metallo-beta-lactamase type 2 1.69 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367974 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367974&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135150042 402364834 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726847 Cc1n[nH]c2cc(F)c(cc12)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)CCN InChI=1S/C17H17FN8O4S2/c1-8-10-6-11(12(18)7-13(10)22-21-8)9-2-3-14(31(27,28)5-4-19)16(32(20,29)30)15(9)17-23-25-26-24-17/h2-3,6-7H,4-5,19H2,1H3,(H,21,22)(H2,20,29,30)(H,23,24,25,26) DQWAONPHIAZRPG-UHFFFAOYSA-N 367975 2-((4-(6-fluoro-3- methyl-1H-indazol-5- yl)-2-sulfamoyl-3-(1H- tetrazol-5- yl)phenyl)sulfonyl) ethanaminium 2,2,2- trifluoroacetate::US10227331, Example 162 Metallo-beta-lactamase type 2 2.81 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367975 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367975&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135149861 402364835 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726850 NCCS(=O)(=O)c1ccc(-c2ccc3[nH]nc(c3c2)C(F)(F)F)c(-c2nnn[nH]2)c1S(N)(=O)=O InChI=1S/C17H15F3N8O4S2/c18-17(19,20)15-10-7-8(1-3-11(10)23-24-15)9-2-4-12(33(29,30)6-5-21)14(34(22,31)32)13(9)16-25-27-28-26-16/h1-4,7H,5-6,21H2,(H,23,24)(H2,22,31,32)(H,25,26,27,28) YGJLBWBFHGZBGM-UHFFFAOYSA-N 367976 2-((2-sulfamoyl-3-(1H- tetrazol-5-yl)-4-(3- (trifluoromethyl)-1H- indazol-5- yl)phenyl)sulfonyl) ethanaminium 2,2,2- trifluoroacetate::US10227331, Example 163 Metallo-beta-lactamase type 2 1.22 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367976 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367976&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135149598 402364836 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726853 COc1ccc(-c2ccc(c(c2-c2nnn[nH]2)S(N)(=O)=O)S(=O)(=O)CCN)c2[nH]c(nc12)C(F)(F)F InChI=1S/C18H17F3N8O5S2/c1-34-10-4-2-9(13-14(10)25-17(24-13)18(19,20)21)8-3-5-11(35(30,31)7-6-22)15(36(23,32)33)12(8)16-26-28-29-27-16/h2-5H,6-7,22H2,1H3,(H,24,25)(H2,23,32,33)(H,26,27,28,29) LLLYCIWIBFCTRU-UHFFFAOYSA-N 367977 2-((4-(4-methoxy-2- (trifluoromethyl)-1H- benzo[d]imidazol-7-yl)- 2-sulfamoyl-3-(1H- tetrazol-5- yl)phenyl)sulfonyl) ethanaminium 2,2,2- trifluoroacetate::US10227331, Example 164 Metallo-beta-lactamase type 2 0.233 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367977 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367977&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135150165 402364837 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727153 Nc1n[nH]c2ccc(cc12)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)C1CNC1 InChI=1S/C17H17N9O4S2/c18-16-11-5-8(1-3-12(11)21-22-16)10-2-4-13(31(27,28)9-6-20-7-9)15(32(19,29)30)14(10)17-23-25-26-24-17/h1-5,9,20H,6-7H2,(H3,18,21,22)(H2,19,29,30)(H,23,24,25,26) CAKBQOGJGZGVGI-UHFFFAOYSA-N 368077 3-(3-amino-1H-indazol-5- yl)-6-(azetidin-3-ylsulfonyl)- 2-(1H-tetrazol-5-yl) benzenesulfonamide::US10227331, Example 264 Metallo-beta-lactamase type 2 1.82 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368077 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368077&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135150148 402364933 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727156 Cn1nc(N)c2c(cccc12)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)C1CNC1 InChI=1S/C18H19N9O4S2/c1-27-12-4-2-3-10(14(12)17(19)24-27)11-5-6-13(32(28,29)9-7-21-8-9)16(33(20,30)31)15(11)18-22-25-26-23-18/h2-6,9,21H,7-8H2,1H3,(H2,19,24)(H2,20,30,31)(H,22,23,25,26) NIGNKUUELMLSFK-UHFFFAOYSA-N 368078 3-(3-amino-1-methyl-1H- indazol-4-yl)-6-(azetidin-3- ylsulfonyl)-2-(1H-tetrazol-5-yl) benzenesulfonamide::US10227331, Example 265 Metallo-beta-lactamase type 2 1.49 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368078 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368078&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135150235 402364934 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727159 Cn1nc(N)c2c(cccc12)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)CCN InChI=1S/C17H19N9O4S2/c1-26-11-4-2-3-9(13(11)16(19)23-26)10-5-6-12(31(27,28)8-7-18)15(32(20,29)30)14(10)17-21-24-25-22-17/h2-6H,7-8,18H2,1H3,(H2,19,23)(H2,20,29,30)(H,21,22,24,25) PZSZHIIJZVIXPJ-UHFFFAOYSA-N 368079 3-(3-amino-1-methyl-1H- indazol-4-yl)-6-((2- aminoethyl)sulfonyl)-2- (1H-tetrazol-5-yl) benzenesulfonamide::US10227331, Example 266 Metallo-beta-lactamase type 2 0.643 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368079 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368079&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135149938 402364935 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727162 C[C@@H](N)CS(=O)(=O)c1ccc(-c2cccc3[nH]c(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C17H17N9O4S2/c1-8(18)7-31(27,28)12-6-5-9(10-3-2-4-11-14(10)22-17(19)21-11)13(15(12)32(20,29)30)16-23-25-26-24-16/h2-6,8H,7,18H2,1H3,(H2,19,21)(H2,20,29,30)/b10-9+/t8-/m1/s1 MMRBNGMXQXYJTP-KGSKPCQNSA-N 368080 3-(2-amino-1H-benzo[d]imidazol-4-yl)-6-((R)-2-aminopropyl sulfonyl)-2-(2H-tetrazol-5-yl)benzenesulfonamide::US10227331, Example 267 Metallo-beta-lactamase type 2 0.964 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368080 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368080&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124159581 402364936 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727327 NCCS(=O)(=O)c1ccc(-c2ccc(cc2)C2CCNCC2)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C20H25N7O4S2/c21-9-12-32(28,29)17-6-5-16(18(19(17)33(22,30)31)20-24-26-27-25-20)15-3-1-13(2-4-15)14-7-10-23-11-8-14/h1-6,14,23H,7-12,21H2,(H2,22,30,31)(H,24,25,26,27) AWHZPWCHMBFZFX-UHFFFAOYSA-N 368135 4-((2-aminoethyl)sulfonyl)-4′-(piperidin-4-yl)-2-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-3-sulfonamide::US10227331, Example 322 Metallo-beta-lactamase type 2 0.170 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368135 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368135&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 145713731 402364986 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727330 NCCS(=O)(=O)c1ccc(-c2cccc3cc([nH]c23)C(N)=O)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C18H18N8O5S2/c19-6-7-32(28,29)13-5-4-10(14(16(13)33(21,30)31)18-23-25-26-24-18)11-3-1-2-9-8-12(17(20)27)22-15(9)11/h1-5,8,22H,6-7,19H2,(H2,20,27)(H2,21,30,31)(H,23,24,25,26) GHMMEVFWFFOIGT-UHFFFAOYSA-N 368136 7-(4-((2-aminoethyl)sulfonyl)-3-sulfamoyl-2-(2H-tetrazol-5-yl)phenyl)-1H-indole-2-carboxamide::US10227331, Example 323 Metallo-beta-lactamase type 2 0.146 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368136 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368136&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 145713732 402364987 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727333 NCCS(=O)(=O)c1ccc(-c2cccc3ncccc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C18H17N7O4S2/c19-8-10-30(26,27)15-7-6-13(11-3-1-5-14-12(11)4-2-9-21-14)16(17(15)31(20,28)29)18-22-24-25-23-18/h1-7,9H,8,10,19H2,(H2,20,28,29)(H,22,23,24,25) WSZGQRAELJZCEA-UHFFFAOYSA-N 368137 6-((2-aminoethyl)sulfonyl)-3- (quinolin-5-yl)-2-(2H- tetrazol-5-yl) benzenesulfonamide::US10227331, Example 324 Metallo-beta-lactamase type 2 0.550 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368137 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368137&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 145713733 402364988 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727336 CNc1nc2c(cccc2s1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)C1CCNCC1 InChI=1S/C20H22N8O4S3/c1-22-20-24-17-13(3-2-4-14(17)33-20)12-5-6-15(34(29,30)11-7-9-23-10-8-11)18(35(21,31)32)16(12)19-25-27-28-26-19/h2-6,11,23H,7-10H2,1H3,(H,22,24)(H2,21,31,32)(H,25,26,27,28) FFOFSTNXZUMUMU-UHFFFAOYSA-N 368138 3-(2-(methylsulfonamido)benzo[d]thiazol-4-yl)-6-(piperidin-4-ylsulfonyl)-2-(2H-tetrazol-5-yl)benzenesulfonamide::US10227331, Example 325 Metallo-beta-lactamase type 2 0.239 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368138 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368138&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 145713734 402364989 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727411 Nc1nc2c(cccc2[nH]1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)[C@@H]1CN[C@H](CO)C1 InChI=1S/C19H19N9O5S2/c20-19-23-13-3-1-2-12(16(13)24-19)11-4-5-14(34(30,31)10-6-9(8-29)22-7-10)17(35(21,32)33)15(11)18-25-27-28-26-18/h1-5,9-10,22,29H,6-8H2,(H2,20,23)(H2,21,32,33)/b12-11+/t9-,10-/m0/s1 MEYSQVVFLBWBTD-UIMDQTJZSA-N 368163 3-(2-Aminobenzo[d]thiazol-4-yl)-6-(((3 S,5S)-5-(hydroxymethyl)pyrrolidin-3-yl) sulfonyl)-2-(2H-tetrazol-5-yl)benzenesulfonamide::US10227331, Example 350 Metallo-beta-lactamase type 2 0.982 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368163 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368163&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135149764 402365013 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727414 NC[C@H](CO)S(=O)(=O)c1ccc(-c2cccc3nc(N)[nH]c23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C17H17N9O5S2/c18-6-8(7-27)32(28,29)12-5-4-9(10-2-1-3-11-14(10)22-17(19)21-11)13(15(12)33(20,30)31)16-23-25-26-24-16/h1-5,8,27H,6-7,18H2,(H2,19,21)(H2,20,30,31)/b10-9+/t8-/m1/s1 XYJXMYDXPRONBQ-KGSKPCQNSA-N 368164 (S)-3-(2-amino-1H-benzo[d]imidazol-7-yl)-6-((1-amino-3-hydroxypropan-2-yl) sulfonyl)-2-(1H-tetrazol-5-yl)benzenesulfonamide::US10227331, Example 351 Metallo-beta-lactamase type 2 1.36 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368164 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368164&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135150128 402365014 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727417 NC[C@@H](O)CS(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O 368165 (R)-6-((3-amino-2- hydroxypropyl)sulfonyl)- 3-(2- aminobenzo[d]thiazol-4- yl)-2-(2H-tetrazol-5-yl) benzenesulfonamide::US10227331, Example 352 Metallo-beta-lactamase type 2 0.145 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368165 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368165&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135149650 402365015 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727420 NC[C@H](O)CS(=O)(=O)c1ccc(-c2cccc3[nH]cnc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C17H16N8O5S2/c18-6-9(26)7-31(27,28)13-5-4-10(11-2-1-3-12-15(11)21-8-20-12)14(16(13)32(19,29)30)17-22-24-25-23-17/h1-5,8-9,26H,6-7,18H2,(H2,19,29,30)/b11-10+/t9-/m0/s1 IWIKEFHGZPKYBE-YHTNPHCKSA-N 368166 (S)-6-((3-amino-2- hydroxypropyl)sulfonyl)- 3-(1H-benzo[d]imidazol- 4-yl)-2-(2H-tetrazol-5-yl) benzenesulfonamide::US10227331, Example 353 Metallo-beta-lactamase type 2 0.392 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368166 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368166&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135149744 402365016 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727423 NCCCS(=O)(=O)c1ccc(-c2cccc3[nH]cnc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C17H18N8O4S2/c18-7-2-8-30(26,27)13-6-5-10(11-3-1-4-12-15(11)21-9-20-12)14(16(13)31(19,28)29)17-22-24-25-23-17/h1,3-6,9H,2,7-8,18H2,(H,20,21)(H2,19,28,29)(H,22,23,24,25) VXZGEHGARFBQME-UHFFFAOYSA-N 368167 6-((3- aminopropyl)sulfonyl)-3- (1H-benzo[d]imidazol-7- yl)-2-(1H-tetrazol-5-yl) benzenesulfonamide::US10227331, Example 354 Metallo-beta-lactamase type 2 0.275 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368167 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368167&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135149995 402365017 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726418 Cn1c(N)nc2cccc(-c3ccc(c(c3-c3nn[nH]n3)S(N)(=O)=O)S(=O)(=O)C3CNC3)c12 InChI=1S/C18H19N9O4S2/c1-27-15-11(3-2-4-12(15)22-18(27)19)10-5-6-13(32(28,29)9-7-21-8-9)16(33(20,30)31)14(10)17-23-25-26-24-17/h2-6,9,21H,7-8H2,1H3,(H2,19,22)(H2,20,30,31)(H,23,24,25,26) NNNOCAGWWKOMCL-UHFFFAOYSA-N 367832 3-(2-Amino-1-methyl-1H-benzo[d]imidazol-7-yl)-6-(azetidin-3-ylsulfonyl)-2-(2H-tetrazol-5-yl)benzenesulfonamide::US10227331, Example 19 Metallo-beta-lactamase type 2 2.50 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367832 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367832&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 145713654 402364692 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726421 Nc1n[nH]c2cc(ccc12)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)C1CNC1 InChI=1S/C17H17N9O4S2/c18-16-11-2-1-8(5-12(11)21-22-16)10-3-4-13(31(27,28)9-6-20-7-9)15(32(19,29)30)14(10)17-23-25-26-24-17/h1-5,9,20H,6-7H2,(H3,18,21,22)(H2,19,29,30)(H,23,24,25,26) MGPOEMJONLJQSP-UHFFFAOYSA-N 367833 3-(3-Amino-1H-indazol-6-yl)-6-azetidin-3-ylsulfonyl)-2-(2H-tetrazol-5-yl)benzenesulfonamide::US10227331, Example 20 Metallo-beta-lactamase type 2 1.19 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367833 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367833&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124157285 402364693 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726424 Nc1n[nH]c2c(cccc12)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)C1CNC1 InChI=1S/C17H17N9O4S2/c18-16-11-3-1-2-10(14(11)21-22-16)9-4-5-12(31(27,28)8-6-20-7-8)15(32(19,29)30)13(9)17-23-25-26-24-17/h1-5,8,20H,6-7H2,(H3,18,21,22)(H2,19,29,30)(H,23,24,25,26) XFQTWHRFIFMAEI-UHFFFAOYSA-N 367834 US10227331, Example 21 Metallo-beta-lactamase type 2 0.639 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367834 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367834&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135149521 402364694 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726427 Cn1c(N)nc2c(cccc12)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)C1CNC1 InChI=1S/C18H19N9O4S2/c1-27-12-4-2-3-11(15(12)22-18(27)19)10-5-6-13(32(28,29)9-7-21-8-9)16(33(20,30)31)14(10)17-23-25-26-24-17/h2-6,9,21H,7-8H2,1H3,(H2,19,22)(H2,20,30,31)(H,23,24,25,26) MIWMAAFSCNDSKG-UHFFFAOYSA-N 367835 US10227331, Example 22 Metallo-beta-lactamase type 2 0.432 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367835 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367835&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 145713655 402364695 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726430 Cc1ccc(-c2ccc(c(c2-c2nn[nH]n2)S(N)(=O)=O)S(=O)(=O)CCN)c2nc(N)[nH]c12 InChI=1S/C17H19N9O4S2/c1-8-2-3-10(14-13(8)21-17(19)22-14)9-4-5-11(31(27,28)7-6-18)15(32(20,29)30)12(9)16-23-25-26-24-16/h2-5H,6-7,18H2,1H3,(H3,19,21,22)(H2,20,29,30)(H,23,24,25,26) XDRQTCJBCDWMJW-UHFFFAOYSA-N 367836 US10227331, Example 23 Metallo-beta-lactamase type 2 0.352 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367836 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367836&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 145713656 402364696 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726658 Cc1cc(cnc1C#N)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)C1CNC1 InChI=1S/C17H16N8O4S2/c1-9-4-10(6-21-13(9)5-18)12-2-3-14(30(26,27)11-7-20-8-11)16(31(19,28)29)15(12)17-22-24-25-23-17/h2-4,6,11,20H,7-8H2,1H3,(H2,19,28,29)(H,22,23,24,25) XJJPLJMFMQPTNI-UHFFFAOYSA-N 367912 3-((4-(6-cyano-5- methylpyridin-3-yl)-2- sulfamoyl-3-(1H- tetrazol-5- yl)phenyl)sulfonyl)azetidin- 1-ium 2,2,2- trifluoroacetate::US10227331, Example 99 Metallo-beta-lactamase type 2 13.7 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367912 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367912&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135150014 402364772 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726661 NS(=O)(=O)c1c(ccc(-c2cccc3[nH]ncc23)c1-c1nnn[nH]1)S(=O)(=O)C1CNC1 InChI=1S/C17H16N8O4S2/c18-31(28,29)16-14(30(26,27)9-6-19-7-9)5-4-11(15(16)17-22-24-25-23-17)10-2-1-3-13-12(10)8-20-21-13/h1-5,8-9,19H,6-7H2,(H,20,21)(H2,18,28,29)(H,22,23,24,25) DMYQXSCSZMABRA-UHFFFAOYSA-N 367913 3-((4-(1H-indazol-4-yl)- 2-sulfamoyl-3-(1H- tetrazol-5- yl)phenyl)sulfonyl)azetidin- 1-ium 2,2,2- trifluoroacetate::US10227331, Example 100 Metallo-beta-lactamase type 2 1.61 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367913 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367913&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135149716 402364773 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726664 NS(=O)(=O)c1c(ccc(-c2cnc3ccoc3c2)c1-c1nnn[nH]1)S(=O)(=O)C1CNC1 InChI=1S/C17H15N7O5S2/c18-31(27,28)16-14(30(25,26)10-7-19-8-10)2-1-11(15(16)17-21-23-24-22-17)9-5-13-12(20-6-9)3-4-29-13/h1-6,10,19H,7-8H2,(H2,18,27,28)(H,21,22,23,24) YRAYUDNKWQOHHK-UHFFFAOYSA-N 367914 3-((4-(furo[3,2-b]pyridin- 6-yl)-2-sulfamoyl-3-(1H- tetrazol-5- yl)phenyl)sulfonyl)azetidin- 1-ium 2,2,2- trifluoroacetate::US10227331, Example 101 Metallo-beta-lactamase type 2 1.48 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367914 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367914&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135150316 402364774 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726667 NS(=O)(=O)c1c(ccc(-c2cccc3ccnn23)c1-c1nnn[nH]1)S(=O)(=O)C1CNC1 InChI=1S/C17H16N8O4S2/c18-31(28,29)16-14(30(26,27)11-8-19-9-11)5-4-12(15(16)17-21-23-24-22-17)13-3-1-2-10-6-7-20-25(10)13/h1-7,11,19H,8-9H2,(H2,18,28,29)(H,21,22,23,24) WBCGUARXBURTTF-UHFFFAOYSA-N 367915 3-((4-(pyrazolo[1,5- a]pyridin-7-yl)-2- sulfamoyl-3-(1H- tetrazol-5- yl)phenyl)sulfonyl)azetidin- 1-ium 2,2,2- trifluoroacetate::US10227331, Example 102 Metallo-beta-lactamase type 2 0.909 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367915 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367915&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135150011 402364775 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726856 NCCS(=O)(=O)c1ccc(-c2ccc3c(c2)[nH]cnc3=O)c(-c2nnn[nH]2)c1S(N)(=O)=O InChI=1S/C17H16N8O5S2/c18-5-6-31(27,28)13-4-3-10(9-1-2-11-12(7-9)20-8-21-17(11)26)14(15(13)32(19,29)30)16-22-24-25-23-16/h1-4,7-8H,5-6,18H2,(H2,19,29,30)(H,20,21,26)(H,22,23,24,25) RPKGNBSPSGWTKL-UHFFFAOYSA-N 367978 2-((4-(4-oxo-1,4- dihydroquinazolin-7-yl)- 2-sulfamoyl-3-(1H- tetrazol-5- yl)phenyl)sulfonyl) ethanaminium 2,2,2- trifluoroacetate::US10227331, Example 165 Metallo-beta-lactamase type 2 1.60 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367978 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367978&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 145713685 402364838 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726859 NCCS(=O)(=O)c1ccc(-c2ccc3C(=O)NCc3c2)c(-c2nnn[nH]2)c1S(N)(=O)=O InChI=1S/C17H17N7O5S2/c18-5-6-30(26,27)13-4-3-11(9-1-2-12-10(7-9)8-20-17(12)25)14(15(13)31(19,28)29)16-21-23-24-22-16/h1-4,7H,5-6,8,18H2,(H,20,25)(H2,19,28,29)(H,21,22,23,24) UOSPYKWNXQSOPH-UHFFFAOYSA-N 367979 2-((4-(1-oxoisoindolin- 5-yl)-2-sulfamoyl-3- (1H-tetrazol-5- yl)phenyl)sulfonyl) ethanaminium 2,2,2- trifluoroacetate::US10227331, Example 166 Metallo-beta-lactamase type 2 1.51 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367979 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367979&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135150307 402364839 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726862 NCCS(=O)(=O)c1ccc(-c2ccc3[nH]ncc3c2)c(-c2nnn[nH]2)c1S(N)(=O)=O InChI=1S/C16H16N8O4S2/c17-5-6-29(25,26)13-4-2-11(9-1-3-12-10(7-9)8-19-20-12)14(15(13)30(18,27)28)16-21-23-24-22-16/h1-4,7-8H,5-6,17H2,(H,19,20)(H2,18,27,28)(H,21,22,23,24) DVBUKYLREULPNY-UHFFFAOYSA-N 367980 2-((4-(1H-indazol-5-yl)- 2-sulfamoyl-3-(1H- tetrazol-5- yl)phenyl)sulfonyl) ethanaminium 2,2,2- trifluoroacetate::US10227331, Example 167 Metallo-beta-lactamase type 2 1.07 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367980 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367980&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135149906 402364840 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727165 C[C@@H](N)CS(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O 368081 3-(2-aminobenzo[d]thiazol-4-yl)-6-((R)-2-aminopropylsulfonyl)-2-(2H-tetrazol-5-yl)benzenesulfonamide::US10227331, Example 268 Metallo-beta-lactamase type 2 0.363 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368081 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368081&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124159665 402364937 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727168 CC(N)CS(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O 368082 3-(2-aminobenzo[d]thiazol-4-yl)-6-(2-aminopropylsulfonyl)-2-(2H-tetrazol-5-yl)benzenesulfonamide::US10227331, Example 269 Metallo-beta-lactamase type 2 0.152 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368082 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368082&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135149568 402364938 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727171 NCCCS(=O)(=O)c1ccc(-c2cccc3[nH]c(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C17H19N9O4S2/c18-7-2-8-31(27,28)12-6-5-9(10-3-1-4-11-14(10)22-17(19)21-11)13(15(12)32(20,29)30)16-23-25-26-24-16/h1,3-6H,2,7-8,18H2,(H3,19,21,22)(H2,20,29,30)(H,23,24,25,26) HOQJJLQXWPAWQR-UHFFFAOYSA-N 368083 3-(2-amino-1H-benzo[d]imidazol-4-yl)-6-(3-aminopropylsulfonyl)-2-(2H-tetrazol-5-yl)benzenesulfonamide dihydrochloride::US10227331, Example 270 Metallo-beta-lactamase type 2 0.625 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368083 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368083&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135149881 402364939 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727174 NCCS(=O)(=O)c1ccc(-c2ccnc3CCCCc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C18H21N7O4S2/c19-8-10-30(26,27)15-6-5-13(11-7-9-21-14-4-2-1-3-12(11)14)16(17(15)31(20,28)29)18-22-24-25-23-18/h5-7,9H,1-4,8,10,19H2,(H2,20,28,29)(H,22,23,24,25) XNADFPWMRRZABC-UHFFFAOYSA-N 368084 6-(2-aminoethylsulfonyl)-3-(5,6,7,8-tetrahydroquinolin-4-yl)-2-(2H-tetrazol-5-yl)benzenesulfonamide and 6-(2-aminoethylsulfonyl)-3-(1,2,3,4-tetrahydroquinolin-4-yl)-2-(2H-tetrazol-5-yl)benzenesulfonamide::US10227331, Example 271::US10227331, Example 272 Metallo-beta-lactamase type 2 0.687 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368084 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368084&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124157214 402364940 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727339 CN(C)CCS(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C18H20N8O4S3/c1-26(2)8-9-32(27,28)13-7-6-10(11-4-3-5-12-15(11)21-18(19)31-12)14(16(13)33(20,29)30)17-22-24-25-23-17/h3-7H,8-9H2,1-2H3,(H2,19,21)(H2,20,29,30)(H,22,23,24,25) RIWPXELKJHELLJ-UHFFFAOYSA-N 368139 3-(2-aminobenzo[d]thiazol-4-yl)-6-((2-(dimethylamino)ethyl)sulfonyl)-2-(2H-tetrazol-5-yl)benzenesulfonamide::US10227331, Example 326 Metallo-beta-lactamase type 2 0.248 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368139 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368139&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124159669 402364990 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727342 NCCS(=O)(=O)c1ccc(-c2cccc3[nH]c(nc23)[C@H](N)CNC(=O)C(F)(F)F)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C20H19F3N10O5S2/c21-20(22,23)19(34)27-8-11(25)17-28-12-3-1-2-10(15(12)29-17)9-4-5-13(39(35,36)7-6-24)16(40(26,37)38)14(9)18-30-32-33-31-18/h1-5,11H,6-8,24-25H2,(H,27,34)(H2,26,37,38)/b10-9-/t11-/m1/s1 FLJACOUUVCCMFT-DWOQACPDSA-N 368140 (R)-6-((2-Aminoethyl)sulfonyl)-3-(2-(1,2-diaminoethyl)-1H-benzo[d]imidazol-4-yl)-2-(2H-tetrazol-5-yl)benzenesulfonamide and (R)—N-(2-Amino-2-(4-(4-((2-aminoethyl)sulfonyl)-3-sulfamoyl-2-(2H-tetrazol-5-yl)phenyl)-1H-benzo[d]imidazol-2-yl)ethyl)-2,2,2-trifluoroacetamide::US10227331, Example 327::US10227331, Example 328 Metallo-beta-lactamase type 2 2.23 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368140 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368140&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 145713735 402364991 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727345 NCCS(=O)(=O)c1ccc(-c2cccc3[nH]c(nc23)[C@H](N)CNC(=O)C(F)(F)F)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C20H19F3N10O5S2/c21-20(22,23)19(34)27-8-11(25)17-28-12-3-1-2-10(15(12)29-17)9-4-5-13(39(35,36)7-6-24)16(40(26,37)38)14(9)18-30-32-33-31-18/h1-5,11H,6-8,24-25H2,(H,27,34)(H2,26,37,38)/b10-9-/t11-/m1/s1 FLJACOUUVCCMFT-DWOQACPDSA-N 368140 (R)-6-((2-Aminoethyl)sulfonyl)-3-(2-(1,2-diaminoethyl)-1H-benzo[d]imidazol-4-yl)-2-(2H-tetrazol-5-yl)benzenesulfonamide and (R)—N-(2-Amino-2-(4-(4-((2-aminoethyl)sulfonyl)-3-sulfamoyl-2-(2H-tetrazol-5-yl)phenyl)-1H-benzo[d]imidazol-2-yl)ethyl)-2,2,2-trifluoroacetamide::US10227331, Example 327::US10227331, Example 328 Metallo-beta-lactamase type 2 3.42 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368140 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368140&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 145713735 402364991 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727348 NCCS(=O)(=O)c1ccc(-c2cccc3[nH]c(nc23)[C@H](N)CO)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C18H19N9O5S2/c19-6-7-33(29,30)13-5-4-9(14(16(13)34(21,31)32)18-24-26-27-25-18)10-2-1-3-12-15(10)23-17(22-12)11(20)8-28/h1-5,11,28H,6-8,19-20H2,(H2,21,31,32)/b10-9+/t11-/m1/s1 YMFBYKBHWNEYQL-PBQZMEPESA-N 368142 (S)-3-(2-(1-amino-2- hydroxyethyl)-1H- benzo[d]imidazol-4-yl)- 6-((2-aminoethyl) sulfonyl)-2- (2H-tetrazol-5-yl) benzenesulfonamide::US10227331, Example 329 Metallo-beta-lactamase type 2 1.93 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368142 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368142&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 145713736 402364992 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727426 C[C@H](N)CS(=O)(=O)c1ccc(-c2cccc3[nH]cnc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C17H16N8O4S2/c1-9(18)7-30(26,27)13-6-5-10(11-3-2-4-12-15(11)21-8-20-12)14(16(13)31(19,28)29)17-22-24-25-23-17/h2-6,8-9H,7,18H2,1H3,(H2,19,28,29)/b11-10+/t9-/m0/s1 DYWDSDYDCBQFEC-YHTNPHCKSA-N 368168 (S)-6-((2- aminopropyl)sulfonyl)-3- (1H-benzo[d]imidazol-4- yl)-2-(2H-tetrazol-5-yl) benzenesulfonamide::US10227331, Example 355 Metallo-beta-lactamase type 2 0.327 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368168 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368168&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135150022 402365018 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727429 N[C@H](CO)CS(=O)(=O)c1ccc(-c2cccc3[nH]cnc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C17H16N8O5S2/c18-9(6-26)7-31(27,28)13-5-4-10(11-2-1-3-12-15(11)21-8-20-12)14(16(13)32(19,29)30)17-22-24-25-23-17/h1-5,8-9,26H,6-7,18H2,(H2,19,29,30)/b11-10+/t9-/m1/s1 ALSVFIJZVBTPPJ-HNLKAFMCSA-N 368169 (R)-6-((2-amino-3- hydroxypropyl)sulfonyl)- 3-(1H-benzo[d]imidazol- 4-yl)-2-(2H-tetrazol-5-yl) benzenesulfonamide::US10227331, Example 356 Metallo-beta-lactamase type 2 0.496 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368169 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368169&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135149729 402365019 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727432 N[C@@H](CO)CS(=O)(=O)c1ccc(-c2cccc3[nH]cnc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C17H16N8O5S2/c18-9(6-26)7-31(27,28)13-5-4-10(11-2-1-3-12-15(11)21-8-20-12)14(16(13)32(19,29)30)17-22-24-25-23-17/h1-5,8-9,26H,6-7,18H2,(H2,19,29,30)/b11-10+/t9-/m0/s1 ALSVFIJZVBTPPJ-YHTNPHCKSA-N 368170 (S)-6-((2-amino-3- hydroxypropyl)sulfonyl)- 3-(1H-benzo[d]imidazol- 4-yl)-2-(2H-tetrazol-5-yl) benzenesulfonamide::US10227331, Example 357 Metallo-beta-lactamase type 2 0.294 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368170 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368170&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135149577 402365020 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727435 NC[C@@H](CO)S(=O)(=O)c1ccc(-c2cccc3nc(N)[nH]c23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C17H17N9O5S2/c18-6-8(7-27)32(28,29)12-5-4-9(10-2-1-3-11-14(10)22-17(19)21-11)13(15(12)33(20,30)31)16-23-25-26-24-16/h1-5,8,27H,6-7,18H2,(H2,19,21)(H2,20,30,31)/b10-9+/t8-/m0/s1 XYJXMYDXPRONBQ-VPOJCXOPSA-N 368171 (S)-3-(2-amino-1H- benzo[d]imidazol-7-yl)-6- ((1-amino-3- hydroxypropan-2- yl)sulfonyl)-2-(1H- tetrazol-5-yl) benzenesulfonamide::US10227331, Example 358 Metallo-beta-lactamase type 2 1.15 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368171 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368171&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135150060 402365021 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726433 Nc1ccc(cn1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)C1CCNCC1 InChI=1S/C17H20N8O4S2/c18-14-4-1-10(9-21-14)12-2-3-13(30(26,27)11-5-7-20-8-6-11)16(31(19,28)29)15(12)17-22-24-25-23-17/h1-4,9,11,20H,5-8H2,(H2,18,21)(H2,19,28,29)(H,22,23,24,25) JQISRMXJZJDADI-UHFFFAOYSA-N 367837 3-(6-aminopyridin-3-yl)-6-(piperidin-4-ylsulfonyl)-2-(2H-tetrazol-5-yl)benzenesulfonamide::US10227331, Example 24 Metallo-beta-lactamase type 2 0.528 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367837 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367837&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 145713657 402364697 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726436 Nc1ccc(cn1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)C1CNC1 InChI=1S/C15H16N8O4S2/c16-12-4-1-8(5-19-12)10-2-3-11(28(24,25)9-6-18-7-9)14(29(17,26)27)13(10)15-20-22-23-21-15/h1-5,9,18H,6-7H2,(H2,16,19)(H2,17,26,27)(H,20,21,22,23) SMMKSMNSJBTZFS-UHFFFAOYSA-N 367838 3-(6-aminopyridin-3-yl)-6-(azetidin-3-ylsulfonyl)-2-(2H-tetrazol-5-yl)benzenesulfonamide::US10227331, Example 25 Metallo-beta-lactamase type 2 0.862 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367838 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367838&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 145713658 402364698 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726439 Nc1c(cccc1B(O)O)C#N InChI=1S/C7H7BN2O2/c9-4-5-2-1-3-6(7(5)10)8(11)12/h1-3,11-12H,10H2 HCBQCTAFMHAHIT-UHFFFAOYSA-N 367839 (2-amino-3- cyanophenyl) boronic acid::US10227331, Example 26::US10544130, Example 11 Metallo-beta-lactamase type 2 0.660 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367839 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367839&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 67038879 402364699 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726442 Nc1nccc(B(O)O)c1N InChI=1S/C5H8BN3O2/c7-4-3(6(10)11)1-2-9-5(4)8/h1-2,10-11H,7H2,(H2,8,9) JOMYRVLPBGOJQE-UHFFFAOYSA-N 367840 (2,3- diaminopyridin-4- yl)boronic acid::US10227331, Example 27 Metallo-beta-lactamase type 2 1.75 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367840 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367840&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 140880810 402364700 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726445 OB(O)c1cccc2[nH]cnc12 InChI=1S/C7H7BN2O2/c11-8(12)5-2-1-3-6-7(5)10-4-9-6/h1-4,11-12H,(H,9,10) UNWJCMBQRPPTIH-UHFFFAOYSA-N 367841 (1H- benzo[d]imidazol- 4-yl)boronic acid::US10227331, Example 28::US10544130, Example 12 Metallo-beta-lactamase type 2 1.33 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367841 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367841&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 45077856 402364701 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726448 CC(C)(C)OC(=O)\N=C(/N)Nc1ccccc1B(O)O InChI=1S/C12H18BN3O4/c1-12(2,3)20-11(17)16-10(14)15-9-7-5-4-6-8(9)13(18)19/h4-7,18-19H,1-3H3,(H3,14,15,16,17) YDQKZYCYYABQNP-UHFFFAOYSA-N 367842 (2-(2-(tert- butoxycarbonyl) guanidino)phenyl) boronic acid::US10227331, Example 29 Metallo-beta-lactamase type 2 0.313 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367842 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367842&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 140880766 402364702 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726670 Cn1cnc2cc(cnc12)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)C1CNC1 InChI=1S/C17H17N9O4S2/c1-26-8-21-12-4-9(5-20-17(12)26)11-2-3-13(31(27,28)10-6-19-7-10)15(32(18,29)30)14(11)16-22-24-25-23-16/h2-5,8,10,19H,6-7H2,1H3,(H2,18,29,30)(H,22,23,24,25) SOFQKHCYWAAOEI-UHFFFAOYSA-N 367916 3-((4-(3-methyl-3H- imidazo[4,5-b]pyridin-6- yl)-2-sulfamoyl-3-(1H- tetrazol-5- yl)phenyl)sulfonyl)azetidin- 1-ium 2,2,2- trifluoroacetate::US10227331, Example 103 Metallo-beta-lactamase type 2 1.85 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367916 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367916&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135149770 402364776 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726673 NS(=O)(=O)c1c(ccc(-c2ccc3ncnn3c2)c1-c1nnn[nH]1)S(=O)(=O)C1CNC1 InChI=1S/C16H15N9O4S2/c17-31(28,29)15-12(30(26,27)10-5-18-6-10)3-2-11(14(15)16-21-23-24-22-16)9-1-4-13-19-8-20-25(13)7-9/h1-4,7-8,10,18H,5-6H2,(H2,17,28,29)(H,21,22,23,24) OKIYLTFGLYVTTE-UHFFFAOYSA-N 367917 3-((4-([1,2,4]triazolo[1,5- a]pyridin-6-yl)-2- sulfamoyl-3-(1H- tetrazol-5- yl)phenyl)sulfonyl)azetidin- 1-ium 2,2,2- trifluoroacetate::US10227331, Example 104 Metallo-beta-lactamase type 2 3.53 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367917 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367917&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135150004 402364777 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726676 Nc1cnccc1-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)C1CNC1 InChI=1S/C15H16N8O4S2/c16-11-7-18-4-3-9(11)10-1-2-12(28(24,25)8-5-19-6-8)14(29(17,26)27)13(10)15-20-22-23-21-15/h1-4,7-8,19H,5-6,16H2,(H2,17,26,27)(H,20,21,22,23) MINAZEFHVKNMIT-UHFFFAOYSA-N 367918 3-((4-(3-aminopyridin-4- yl)-2-sulfamoyl-3-(1H- tetrazol-5- yl)phenyl)sulfonyl)azetidin- 1-ium 2,2,2- trifluoroacetate::US10227331, Example 105 Metallo-beta-lactamase type 2 1.69 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367918 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367918&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135149735 402364778 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726679 CNc1ncc(cn1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)C1CNC1 InChI=1S/C15H17N9O4S2/c1-17-15-19-4-8(5-20-15)10-2-3-11(29(25,26)9-6-18-7-9)13(30(16,27)28)12(10)14-21-23-24-22-14/h2-5,9,18H,6-7H2,1H3,(H2,16,27,28)(H,17,19,20)(H,21,22,23,24) RKBNNUDLQWHUEG-UHFFFAOYSA-N 367919 3-((4-(2- (methylamino)pyrimidin- 5-yl)-2-sulfamoyl-3-(1H- tetrazol-5- yl)phenyl)sulfonyl)azetidin- 1-ium 2,2,2- trifluoroacetate::US10227331, Example 106 Metallo-beta-lactamase type 2 3.27 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367919 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367919&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135150210 402364779 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726682 NCc1cncc(c1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)C1CNC1 InChI=1S/C16H18N8O4S2/c17-4-9-3-10(6-19-5-9)12-1-2-13(29(25,26)11-7-20-8-11)15(30(18,27)28)14(12)16-21-23-24-22-16/h1-3,5-6,11,20H,4,7-8,17H2,(H2,18,27,28)(H,21,22,23,24) ZTDXWWAYWICDRB-UHFFFAOYSA-N 367920 3-((4-(5- (aminomethyl)pyridin-3- yl)-2-sulfamoyl-3-(1H- tetrazol-5- yl)phenyl)sulfonyl)azetidin- 1-ium 2,2,2- trifluoroacetate::US10227331, Example 107 Metallo-beta-lactamase type 2 121 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367920 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367920&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135149653 402364780 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726865 NCCS(=O)(=O)c1ccc(-c2cnc(N)c(F)c2)c(-c2nnn[nH]2)c1S(N)(=O)=O InChI=1S/C14H15FN8O4S2/c15-9-5-7(6-19-13(9)17)8-1-2-10(28(24,25)4-3-16)12(29(18,26)27)11(8)14-20-22-23-21-14/h1-2,5-6H,3-4,16H2,(H2,17,19)(H2,18,26,27)(H,20,21,22,23) AVJAOKMVROOCDA-UHFFFAOYSA-N 367981 2-((4-(6-amino-5- fluoropyridin-3-yl)-2- sulfamoyl-3-(1H- tetrazol-5- yl)phenyl)sulfonyl) ethanaminium 2,2,2- trifluoroacetate::US10227331, Example 168 Metallo-beta-lactamase type 2 2.02 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367981 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367981&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135149535 402364841 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726868 COc1cc(cnc1N)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)CCN InChI=1S/C15H18N8O5S2/c1-28-10-6-8(7-19-14(10)17)9-2-3-11(29(24,25)5-4-16)13(30(18,26)27)12(9)15-20-22-23-21-15/h2-3,6-7H,4-5,16H2,1H3,(H2,17,19)(H2,18,26,27)(H,20,21,22,23) RJSYDNYMNMBKSR-UHFFFAOYSA-N 367982 2-((4-(6-amino-5- methoxypyridin-3-yl)-2- sulfamoyl-3-(1H- tetrazol-5- yl)phenyl)sulfonyl) ethanaminium 2,2,2- trifluoroacetate::US10227331, Example 169 Metallo-beta-lactamase type 2 5.27 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367982 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367982&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135149821 402364842 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726871 Cc1nc(N)ccc1-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)CCN InChI=1S/C15H18N8O4S2/c1-8-9(3-5-12(17)19-8)10-2-4-11(28(24,25)7-6-16)14(29(18,26)27)13(10)15-20-22-23-21-15/h2-5H,6-7,16H2,1H3,(H2,17,19)(H2,18,26,27)(H,20,21,22,23) MUSFGBZLDXSWRW-UHFFFAOYSA-N 367983 2-((4-(6-amino-2- methylpyridin-3-yl)-2- sulfamoyl-3-(1H- tetrazol-5- yl)phenyl)sulfonyl) ethanaminium 2,2,2- trifluoroacetate::US10227331, Example 170 Metallo-beta-lactamase type 2 2.87 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367983 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367983&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135149619 402364843 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726874 NCCS(=O)(=O)c1ccc(-c2cccc3cnccc23)c(-c2nnn[nH]2)c1S(N)(=O)=O InChI=1S/C18H17N7O4S2/c19-7-9-30(26,27)15-5-4-14(13-3-1-2-11-10-21-8-6-12(11)13)16(17(15)31(20,28)29)18-22-24-25-23-18/h1-6,8,10H,7,9,19H2,(H2,20,28,29)(H,22,23,24,25) QRZCJVIIIQFGHZ-UHFFFAOYSA-N 367984 2-((4-isoquinolin-5-yl)- 2-sulfamoyl-3-(1H- tetrazol-5- yl)phenyl)sulfonyl) ethanaminium 2,2,2- trifluoroacetate::US10227331, Example 171 Metallo-beta-lactamase type 2 1.02 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367984 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367984&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135165665 402364844 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726901 N[C@H]1C[C@H](C1)S(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O 367993 3-(2-aminobenzo[d]thiazol-4- yl)-6-((1s,3s)-3- aminocyclobutylsulfonyl)-2- (2H-tetrazol-5- yl)benzenesulfonamide::US10227331, Example 180 Metallo-beta-lactamase type 2 0.260 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367993 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367993&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135149502 402364852 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726904 Nc1nc2cccc(-c3ccc(c(c3-c3nn[nH]n3)S(N)(=O)=O)S(=O)(=O)[C@@H]3CCNC3)c2[nH]1 InChI=1S/C18H17N9O4S2/c19-18-22-12-3-1-2-11(15(12)23-18)10-4-5-13(32(28,29)9-6-7-21-8-9)16(33(20,30)31)14(10)17-24-26-27-25-17/h1-5,9,21H,6-8H2,(H2,19,22)(H2,20,30,31)/b11-10+/t9-/m1/s1 YEVZLYMETBZUBO-HNLKAFMCSA-N 367994 3-(2-amino-3H-benzo[d]imidazol-4-yl)-6-((R)-pyrrolidin-3-ylsulfonyl)-2-(2H-tetrazol-5-yl)benzenesulfonamide::US10227331, Example 181 Metallo-beta-lactamase type 2 0.807 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367994 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367994&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135149963 402364853 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726907 Nc1nc2cccc(-c3ccc(c(c3-c3nn[nH]n3)S(N)(=O)=O)S(=O)(=O)[C@H]3CCNC3)c2[nH]1 InChI=1S/C18H17N9O4S2/c19-18-22-12-3-1-2-11(15(12)23-18)10-4-5-13(32(28,29)9-6-7-21-8-9)16(33(20,30)31)14(10)17-24-26-27-25-17/h1-5,9,21H,6-8H2,(H2,19,22)(H2,20,30,31)/b11-10+/t9-/m0/s1 YEVZLYMETBZUBO-YHTNPHCKSA-N 367995 3-(2-amino-3H- benzo[d]imidazol-4-yl)-6-((S)- pyrrolidin-3-ylsulfonyl)-2-(2H- tetrazol-5- yl)benzenesulfonamide::US10227331, Example 182 Metallo-beta-lactamase type 2 0.979 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367995 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367995&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135149660 402364854 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726910 Nc1nc2c(cccc2s1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)[C@@H]1CCNC1 367996 3-(2-aminobenzo[d]thiazol-4- yl)-6((R)-pyrrolidin-3- ylsulfonyl)-2-(2H-tetrazol-5- yl)benzenesulfonamide::US10227331, Example 183 Metallo-beta-lactamase type 2 0.157 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367996 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367996&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135150295 402364855 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726913 Nc1nc2c(cccc2s1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)[C@H]1CCNC1 367997 3-(2-aminobenzo[d]thiazol-4- yl)-6-((S)-pyrrolidin-3- ylsulfonyl)-2-(2H-tetrazol-5- yl)benzenesulfonamide::US10227331, Example 184 Metallo-beta-lactamase type 2 0.243 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367997 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367997&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135149921 402364856 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727177 NCCS(=O)(=O)c1ccc(-c2ccnc3CCCCc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C18H21N7O4S2/c19-8-10-30(26,27)15-6-5-13(11-7-9-21-14-4-2-1-3-12(11)14)16(17(15)31(20,28)29)18-22-24-25-23-18/h5-7,9H,1-4,8,10,19H2,(H2,20,28,29)(H,22,23,24,25) XNADFPWMRRZABC-UHFFFAOYSA-N 368084 6-(2-aminoethylsulfonyl)-3-(5,6,7,8-tetrahydroquinolin-4-yl)-2-(2H-tetrazol-5-yl)benzenesulfonamide and 6-(2-aminoethylsulfonyl)-3-(1,2,3,4-tetrahydroquinolin-4-yl)-2-(2H-tetrazol-5-yl)benzenesulfonamide::US10227331, Example 271::US10227331, Example 272 Metallo-beta-lactamase type 2 6.06 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368084 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368084&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124157214 402364940 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727180 N[C@H](CO)CS(=O)(=O)c1ccc(-c2cccc3[nH]c(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C17H17N9O5S2/c18-8(6-27)7-32(28,29)12-5-4-9(10-2-1-3-11-14(10)22-17(19)21-11)13(15(12)33(20,30)31)16-23-25-26-24-16/h1-5,8,27H,6-7,18H2,(H2,19,21)(H2,20,30,31)/b10-9+/t8-/m1/s1 WOATXFHMBXNLGE-KGSKPCQNSA-N 368086 3-(2-amino-1H-benzo[d]imidazol-4-yl)-6-((R)-2-amino-3-hydroxypropylsulfonyl)-2-(2H-tetrazol-5-yl)benzenesulfonamide::US10227331, Example 273 Metallo-beta-lactamase type 2 0.709 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368086 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368086&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135149898 402364941 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727183 N[C@@H](CO)CS(=O)(=O)c1ccc(-c2cccc3[nH]c(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C17H17N9O5S2/c18-8(6-27)7-32(28,29)12-5-4-9(10-2-1-3-11-14(10)22-17(19)21-11)13(15(12)33(20,30)31)16-23-25-26-24-16/h1-5,8,27H,6-7,18H2,(H2,19,21)(H2,20,30,31)/b10-9+/t8-/m0/s1 WOATXFHMBXNLGE-VPOJCXOPSA-N 368087 3-(2-amino-1H-benzo[d]imidazol-4-yl)-6-((S)-2-amino-3-hydroxypropylsulfonyl)-2-(2H-tetrazol-5-yl)benzenesulfonamide::US10227331, Example 274 Metallo-beta-lactamase type 2 0.431 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368087 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368087&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124159751 402364942 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727186 C[C@@H](N)CS(=O)(=O)c1ccc(-c2cccc3n(C)c(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O 368088 3-(2-amino-1-methyl-1H-benzo[d]imidazol-4-yl)-6-((R)-2-aminopropylsulfonyl)-2-(2H-tetrazol-5-yl)benzenesulfonamide::US10227331, Example 275 Metallo-beta-lactamase type 2 0.840 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368088 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368088&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124159597 402364943 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727351 NCCS(=O)(=O)c1ccc(-c2cccc3[nH]c(CC(N)C(O)=O)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C19H19N9O6S2/c20-6-7-35(31,32)13-5-4-9(15(17(13)36(22,33)34)18-25-27-28-26-18)10-2-1-3-12-16(10)24-14(23-12)8-11(21)19(29)30/h1-5,11H,6-8,20-21H2,(H,29,30)(H2,22,33,34)/b10-9+ AMLLMWMIFRVKKA-MDZDMXLPSA-N 368143 2-amino-3-(4-(4-((2- aminoethyl)sulfonyl)- 3-sulfamoyl-2-(2H- tetrazol-5-yl)phenyl)- 1H-benzo[d]imidazol- 2-yl)propanoic acid::US10227331, Example 330 Metallo-beta-lactamase type 2 3.61 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368143 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368143&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 145713737 402364993 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727354 Cc1nc2c(cccc2[nH]1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)CCN InChI=1S/C17H18N8O4S2/c1-9-20-12-4-2-3-11(15(12)21-9)10-5-6-13(30(26,27)8-7-18)16(31(19,28)29)14(10)17-22-24-25-23-17/h2-6H,7-8,18H2,1H3,(H,20,21)(H2,19,28,29)(H,22,23,24,25) CMMQUPMVPKKYRI-UHFFFAOYSA-N 368144 6-((2- aminoethyl)sulfonyl)- 3-(2-methyl-1H- benzo[d]imidazol-4- yl)-2-(2H-tetrazol-5-yl) benzenesulfonamide::US10227331, Example 331 Metallo-beta-lactamase type 2 0.302 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368144 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368144&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 145713738 402364994 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727357 NS(=O)(=O)c1c(ccc(-c2cccc3[nH]cnc23)c1-c1nn[nH]n1)S(=O)(=O)C1CNC1 InChI=1S/C17H16N8O4S2/c18-31(28,29)16-13(30(26,27)9-6-19-7-9)5-4-10(14(16)17-22-24-25-23-17)11-2-1-3-12-15(11)21-8-20-12/h1-5,8-9,19H,6-7H2,(H,20,21)(H2,18,28,29)(H,22,23,24,25) MSWIMBNZOYBDDN-UHFFFAOYSA-N 368145 6-(Azetidin-3-ylsulfonyl)-3-(1H-benzo[d]imidazol-4-yl)-2-(2H-tetrazol-5-yl)benzenesulfonamide::US10227331, Example 332 Metallo-beta-lactamase type 2 0.557 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368145 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368145&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 145713739 402364995 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727360 NCCS(=O)(=O)c1ccc(-c2cccc(NC(=O)CN)c2)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C17H20N8O5S2/c18-6-7-31(27,28)13-5-4-12(10-2-1-3-11(8-10)21-14(26)9-19)15(16(13)32(20,29)30)17-22-24-25-23-17/h1-5,8H,6-7,9,18-19H2,(H,21,26)(H2,20,29,30)(H,22,23,24,25) KOLXJQLQKOCNIE-UHFFFAOYSA-N 368146 2-Amino-N-(4′-((2-aminoethyl)sulfonyl)-3′-sulfamoyl-2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-3-yl)acetamide::US10227331, Example 333 Metallo-beta-lactamase type 2 10.3 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368146 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368146&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 145713740 402364996 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727438 C[C@@H](N)CS(=O)(=O)c1ccc(-c2cccc3[nH]cnc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C17H16N8O4S2/c1-9(18)7-30(26,27)13-6-5-10(11-3-2-4-12-15(11)21-8-20-12)14(16(13)31(19,28)29)17-22-24-25-23-17/h2-6,8-9H,7,18H2,1H3,(H2,19,28,29)/b11-10+/t9-/m1/s1 DYWDSDYDCBQFEC-HNLKAFMCSA-N 368172 (S)-4-(2-amino-1H- benzo[d]imidazol-7-yl)- N1-methyl-N1-(pyrrolidin- 3-yl)-3-(1H-tetrazol-5- yl)benzene-1,2- disulfonamide::US10227331, Example 359 Metallo-beta-lactamase type 2 0.454 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368172 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368172&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135176907 402365022 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727441 NC[C@@H](N)CS(=O)(=O)c1ccc(-c2cccc3[nH]c(N)nc23)c(-c2cn[nH]n2)c1S(N)(=O)=O InChI=1S/C18H19N9O4S2/c19-6-9(20)8-32(28,29)14-5-4-10(11-2-1-3-12-16(11)25-18(21)24-12)15(13-7-23-27-26-13)17(14)33(22,30)31/h1-5,7,9H,6,8,19-20H2,(H2,21,24)(H2,22,30,31)/b11-10+,15-13-/t9-/m1/s1 GZRQNZHLESOPFA-FKCYYORQSA-N 368173 (R)-3-(2-amino-1H- benzo[d]imidazol-4-yl)-6- ((2,3- diaminopropyl)sulfonyl)- 2-(2H-tetrazol-5-yl) benzenesulfonamide::US10227331, Example 360 Metallo-beta-lactamase type 2 0.544 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368173 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368173&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135177229 402365023 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727444 NC[C@@H](O)CS(=O)(=O)c1ccc(-c2cccc3[nH]cnc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C17H16N8O5S2/c18-6-9(26)7-31(27,28)13-5-4-10(11-2-1-3-12-15(11)21-8-20-12)14(16(13)32(19,29)30)17-22-24-25-23-17/h1-5,8-9,26H,6-7,18H2,(H2,19,29,30)/b11-10+/t9-/m1/s1 IWIKEFHGZPKYBE-HNLKAFMCSA-N 368174 (R)-6-((3-amino-2- hydroxypropyl)sulfonyl)- 3-(1H-benzo[d]imidazol- 4-yl)-2-(2H-tetrazol-5-yl) benzenesulfonamide::US10227331, Example 361 Metallo-beta-lactamase type 2 0.174 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368174 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368174&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135149968 402365024 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727447 Cn1c(N)nc2c(cccc12)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)C[C@H](O)CN 368175 (R)-3-(2-amino-1-methyl- 1H-benzo[d]imidazol-4- yl)-6-((3-amino-2- hydroxypropyl)sulfonyl)- 2-(2H-tetrazol-5-yl) benzenesulfonamide::US10227331, Example 362 Metallo-beta-lactamase type 2 0.408 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368175 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368175&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135149727 402365025 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727450 Cn1c(N)nc2c(cccc12)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)C[C@@H](O)CN 368176 (S)-3-(2-amino-1-methyl- 1H-benzo[d]imidazol-4- yl)-6-((3-amino-2- hydroxypropyl)sulfonyl)- 2-(2H-tetrazol-5-yl) benzenesulfonamide::US10227331, Example 363 Metallo-beta-lactamase type 2 0.425 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368176 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368176&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135149942 402365026 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726451 Nc1nc2c(cccc2o1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)C1CNC1 InChI=1S/C17H16N8O5S2/c18-17-21-14-10(2-1-3-11(14)30-17)9-4-5-12(31(26,27)8-6-20-7-8)15(32(19,28)29)13(9)16-22-24-25-23-16/h1-5,8,20H,6-7H2,(H2,18,21)(H2,19,28,29)(H,22,23,24,25) WXJODLWKEHPPCN-UHFFFAOYSA-N 367843 3-(2-aminobenzo[d]oxazol- 4-yl)-6-(azetidin-3- ylsulfonyl)-2-(2H-tetrazol- 5-yl)benzenesulfonamide::US10227331, Example 30 Metallo-beta-lactamase type 2 0.585 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367843 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367843&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 145713659 402364703 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726454 Nc1nc2cc(ccc2o1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)C1CNC1 InChI=1S/C17H16N8O5S2/c18-17-21-11-5-8(1-3-12(11)30-17)10-2-4-13(31(26,27)9-6-20-7-9)15(32(19,28)29)14(10)16-22-24-25-23-16/h1-5,9,20H,6-7H2,(H2,18,21)(H2,19,28,29)(H,22,23,24,25) CPFZNXYAEFLUNM-UHFFFAOYSA-N 367844 3-(2-aminobenzo[d]oxazol- 5-yl)-6-(azetidin-3- ylsulfonyl)-2-(2H-tetrazol- 5-yl)benzenesulfonamide::US10227331, Example 31 Metallo-beta-lactamase type 2 1.37 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367844 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367844&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 145713660 402364704 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726457 Cc1ccc(-c2ccc(c(c2-c2nn[nH]n2)S(N)(=O)=O)S(=O)(=O)C2CNC2)c2nc(N)sc12 InChI=1S/C18H18N8O4S3/c1-8-2-3-11(14-15(8)31-18(19)22-14)10-4-5-12(32(27,28)9-6-21-7-9)16(33(20,29)30)13(10)17-23-25-26-24-17/h2-5,9,21H,6-7H2,1H3,(H2,19,22)(H2,20,29,30)(H,23,24,25,26) FENLKZTUOZTGHO-UHFFFAOYSA-N 367845 3-(2-amino-7- methylbenzo[d]thiazol-4- yl)-6-(azetidin-3- ylsulfonyl)-2-(2H-tetrazol- 5-yl)benzenesulfonamide::US10227331, Example 32 Metallo-beta-lactamase type 2 0.138 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367845 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367845&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 145713661 402364705 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726460 Cc1ccc(-c2ccc(c(c2-c2nn[nH]n2)S(N)(=O)=O)S(=O)(=O)C2CNC2)c2sc(N)nc12 InChI=1S/C18H18N8O4S3/c1-8-2-3-11(15-14(8)22-18(19)31-15)10-4-5-12(32(27,28)9-6-21-7-9)16(33(20,29)30)13(10)17-23-25-26-24-17/h2-5,9,21H,6-7H2,1H3,(H2,19,22)(H2,20,29,30)(H,23,24,25,26) GOPOAJQHNBPWRP-UHFFFAOYSA-N 367846 3-(2-amino-4- methylbenzo[d]thiazol-7- yl)-6-(azetidin-3- ylsulfonyl)-2-(2H-tetrazol- 5-yl)benzenesulfonamide::US10227331, Example 33 Metallo-beta-lactamase type 2 0.296 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367846 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367846&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 145713662 402364706 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726463 Nc1nc2c(ccc(c2s1)C(F)(F)F)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)C1CNC1 InChI=1S/C18H15F3N8O4S3/c19-18(20,21)10-3-1-9(13-14(10)34-17(22)25-13)8-2-4-11(35(30,31)7-5-24-6-7)15(36(23,32)33)12(8)16-26-28-29-27-16/h1-4,7,24H,5-6H2,(H2,22,25)(H2,23,32,33)(H,26,27,28,29) WWVBMIIORPYIMQ-UHFFFAOYSA-N 367847 3-(2-amino-7- (trifluoromethyl)benzo[d] thiazol-4-yl)-6-(azetidin-3- ylsulfonyl)-2-(2H-tetrazol- 5-yl)benzenesulfonamide::US10227331, Example 34 Metallo-beta-lactamase type 2 0.229 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367847 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367847&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 145713663 402364707 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726466 Nc1cc2cccc(-c3ccc(c(c3-c3nn[nH]n3)S(N)(=O)=O)S(=O)(=O)C3CNC3)c2cn1 InChI=1S/C19H18N8O4S2/c20-16-6-10-2-1-3-12(14(10)9-23-16)13-4-5-15(32(28,29)11-7-22-8-11)18(33(21,30)31)17(13)19-24-26-27-25-19/h1-6,9,11,22H,7-8H2,(H2,20,23)(H2,21,30,31)(H,24,25,26,27) BLXZAIBKQOYUSB-UHFFFAOYSA-N 367848 3-(3-aminoisoquinolin-8- yl)-6-(azetidin-3- ylsulfonyl)-2-(2H-tetrazol- 5-yl)benzenesulfonamide::US10227331, Example 35 Metallo-beta-lactamase type 2 0.503 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367848 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367848&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 145713664 402364708 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726685 NS(=O)(=O)c1c(ccc(C2=CC3C=NNC3N=C2)c1-c1nnn[nH]1)S(=O)(=O)C1CNC1 367921 3-((4-(3a,7a-dihydro-1H- pyrazolo[3,4-b]pyridin-5- yl)-2-sulfamoyl-3-(1H- tetrazol-5- yl)phenyl)sulfonyl)azetid in-1-ium 2,2,2- trifluoroacetate::US10227331, Example 108 Metallo-beta-lactamase type 2 3.71 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367921 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367921&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135149673 402364781 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726688 NS(=O)(=O)c1c(ccc(-c2ccc(O)nc2)c1-c1nnn[nH]1)S(=O)(=O)C1CNC1 InChI=1S/C15H15N7O5S2/c16-29(26,27)14-11(28(24,25)9-6-17-7-9)3-2-10(8-1-4-12(23)18-5-8)13(14)15-19-21-22-20-15/h1-5,9,17H,6-7H2,(H,18,23)(H2,16,26,27)(H,19,20,21,22) CCKYDJAMNOBVOW-UHFFFAOYSA-N 367922 3-((4-(6-hydroxypyridin- 3-yl)-2-sulfamoyl-3-(1H- tetrazol-5- yl)phenyl)sulfonyl)azetidin- 1-ium 2,2,2- trifluoroacetate::US10227331, Example 109 Metallo-beta-lactamase type 2 9.13 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367922 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367922&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135149565 402364782 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726691 NS(=O)(=O)c1c(ccc(-c2cncnc2)c1-c1nnn[nH]1)S(=O)(=O)C1CNC1 InChI=1S/C14H14N8O4S2/c15-28(25,26)13-11(27(23,24)9-5-16-6-9)2-1-10(8-3-17-7-18-4-8)12(13)14-19-21-22-20-14/h1-4,7,9,16H,5-6H2,(H2,15,25,26)(H,19,20,21,22) QPNNOKHQMJPTHY-UHFFFAOYSA-N 367923 3-((4-(pyrimidin-5-yl)-2- sulfamoyl-3-(1H- tetrazol-5- yl)phenyl)sulfonyl)azetidin- 1-ium 2,2,2- trifluoroacetate::US10227331, Example 110 Metallo-beta-lactamase type 2 13.2 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367923 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367923&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135149793 402364783 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726694 NS(=O)(=O)c1c(ccc(-c2ccc(CO)nc2)c1-c1nnn[nH]1)S(=O)(=O)C1CNC1 InChI=1S/C16H17N7O5S2/c17-30(27,28)15-13(29(25,26)11-6-18-7-11)4-3-12(14(15)16-20-22-23-21-16)9-1-2-10(8-24)19-5-9/h1-5,11,18,24H,6-8H2,(H2,17,27,28)(H,20,21,22,23) WHWVRZVCQWXGEM-UHFFFAOYSA-N 367924 3-((4-(6- (hydroxymethyl)pyridin- 3-yl)-2-sulfamoyl-3-(1H- tetrazol-5- yl)phenyl)sulfonyl)azetidin- 1-ium 2,2,2- trifluoroacetate::US10227331, Example 111 Metallo-beta-lactamase type 2 4.42 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367924 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367924&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135150028 402364784 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726877 Cc1cc(cnc1N)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)CCN InChI=1S/C15H18N8O4S2/c1-8-6-9(7-19-14(8)17)10-2-3-11(28(24,25)5-4-16)13(29(18,26)27)12(10)15-20-22-23-21-15/h2-3,6-7H,4-5,16H2,1H3,(H2,17,19)(H2,18,26,27)(H,20,21,22,23) HJJLHTPJTXMJPU-UHFFFAOYSA-N 367985 2-((4-(6-amino-5- methylpyridin-3-yl)-2- sulfamoyl-3-(1H- tetrazol-5- yl)phenyl)sulfonyl) ethanaminium 2,2,2- trifluoroacetate::US10227331, Example 172 Metallo-beta-lactamase type 2 4.90 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367985 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367985&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135149623 402364845 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726880 NCCS(=O)(=O)c1ccc(-c2cccc3cn[nH]c23)c(-c2nnn[nH]2)c1S(N)(=O)=O InChI=1S/C16H16N8O4S2/c17-6-7-29(25,26)12-5-4-10(11-3-1-2-9-8-19-20-14(9)11)13(15(12)30(18,27)28)16-21-23-24-22-16/h1-5,8H,6-7,17H2,(H,19,20)(H2,18,27,28)(H,21,22,23,24) SNHBVLHRDICBIW-UHFFFAOYSA-N 367986 2-((4-(1H-indazol-7-yl)- 2-sulfamoyl-3-(1H- tetrazol-5- yl)phenyl)sulfonyl) ethanaminium 2,2,2- trifluoroacetate::US10227331, Example 173::US10227331, Example 298 Metallo-beta-lactamase type 2 0.160 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367986 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367986&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135149710 402364846 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726883 NCCS(=O)(=O)c1ccc(-c2ccc3scnc3c2)c(-c2nnn[nH]2)c1S(N)(=O)=O InChI=1S/C16H15N7O4S3/c17-5-6-29(24,25)13-4-2-10(9-1-3-12-11(7-9)19-8-28-12)14(15(13)30(18,26)27)16-20-22-23-21-16/h1-4,7-8H,5-6,17H2,(H2,18,26,27)(H,20,21,22,23) UXIZJDZGYKQOGN-UHFFFAOYSA-N 367987 2-((4-(benzo[d]thiazol- 5-yl)-2-sulfamoyl-3 (1H-tetrazol-5- yl)phenyl)sulfonyl) ethanaminium 2,2,2- trifluoroacetate::US10227331, Example 174 Metallo-beta-lactamase type 2 0.220 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367987 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367987&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135149853 402364847 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726886 N[C@H]1C[C@@H](C1)S(=O)(=O)c1ccc(-c2cccc3nc(N)[nH]c23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C18H17N9O4S2/c19-8-6-9(7-8)32(28,29)13-5-4-10(11-2-1-3-12-15(11)23-18(20)22-12)14(16(13)33(21,30)31)17-24-26-27-25-17/h1-5,8-9H,6-7,19H2,(H2,20,22)(H2,21,30,31)/b11-10+/t8-,9- OAECODSJNPAUFS-RGESTZRMSA-N 367988 3-(2-amino-3H-benzo[d]imidazol-4-yl)-6-((1r,3r)-3-aminocyclobutylsulfonyl)-2-(2H-tetrazol-5-yl)benzenesulfonamide and 3-(2-amino-3H-benzo[d]imidazol-4-yl)-6-((1s, 3s)-3-aminocyclobutylsulfonyl)-2-(2H-tetrazol-5-yl)benzenesulfonamide::US10227331, Example 175::US10227331, Example 176 Metallo-beta-lactamase type 2 2.20 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367988 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367988&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135149758 402364848 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727030 Nc1cccc(n1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)C1CNC1 InChI=1S/C15H16N8O4S2/c16-12-3-1-2-10(19-12)9-4-5-11(28(24,25)8-6-18-7-8)14(29(17,26)27)13(9)15-20-22-23-21-15/h1-5,8,18H,6-7H2,(H2,16,19)(H2,17,26,27)(H,20,21,22,23) ULYSJUFNOYQBOV-UHFFFAOYSA-N 368036 3-(6-aminopyridin-2-yl)-6-(azetidin-3-ylsulfonyl)-2-(2H-tetrazol-5-yl)benzenesulfonamide::US10227331, Example 223 Metallo-beta-lactamase type 2 10.2 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368036 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368036&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124157556 402364895 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727033 Nc1nccc(c1N)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)C1CNC1 InChI=1S/C15H17N9O4S2/c16-12-9(3-4-20-14(12)17)8-1-2-10(29(25,26)7-5-19-6-7)13(30(18,27)28)11(8)15-21-23-24-22-15/h1-4,7,19H,5-6,16H2,(H2,17,20)(H2,18,27,28)(H,21,22,23,24) VSMPVQJXIMVOLF-UHFFFAOYSA-N 368037 6-(azetidin-3-ylsulfonyl)-3-(2,3-diaminopyridin-4-yl)-2-(2H-tetrazol-5-yl)benzenesulfonamide::US10227331, Example 224 Metallo-beta-lactamase type 2 2.58 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368037 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368037&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124157316 402364896 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727036 NCCS(=O)(=O)c1ccc(-c2cccc3nc(N)nn23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C15H16N10O4S2/c16-6-7-30(26,27)10-5-4-8(9-2-1-3-11-19-15(17)22-25(9)11)12(13(10)31(18,28)29)14-20-23-24-21-14/h1-5H,6-7,16H2,(H2,17,22)(H2,18,28,29)(H,20,21,23,24) HNGPYHSEAFQMJS-UHFFFAOYSA-N 368038 3-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-5-yl)-6-((2-aminoethyl)sulfonyl)-2-(2H-tetrazol-5-yl)benzenesulfonamide::US10227331, Example 225 Metallo-beta-lactamase type 2 1.96 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368038 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368038&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124157512 402364897 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727039 NS(=O)(=O)c1c(SC2CCNCC2)ccc(-c2ccc(cc2)C2CCNCC2)c1-c1nnn[nH]1 InChI=1S/C23H29N7O2S2/c24-34(31,32)22-20(33-18-9-13-26-14-10-18)6-5-19(21(22)23-27-29-30-28-23)17-3-1-15(2-4-17)16-7-11-25-12-8-16/h1-6,16,18,25-26H,7-14H2,(H2,24,31,32)(H,27,28,29,30) KTLKWWIZCBHJBC-UHFFFAOYSA-N 368039 4′-(piperidin-4-yl)-4-(piperidin-4-ylthio)-2-(1H-tetrazol-5-yl)-[1,1′-biphenyl]-3-sulfonamide::US10227331, Example 226 Metallo-beta-lactamase type 2 35.7 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368039 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368039&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 145713695 402364898 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727189 C[C@H](N)CS(=O)(=O)c1ccc(-c2cccc3n(C)c(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O 368089 3-(2-amino-1-methyl-1H-benzo[d]imidazol-4-yl)-6-((S)-2-aminopropylsulfonyl)-2-(2H-tetrazol-5-yl)benzenesulfonamide::US10227331, Example 276 Metallo-beta-lactamase type 2 0.285 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368089 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368089&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124159636 402364944 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727192 C[C@H](CN)S(=O)(=O)c1ccc(-c2cccc3nc(N)[nH]c23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C17H17N9O4S2/c1-8(7-18)31(27,28)12-6-5-9(10-3-2-4-11-14(10)22-17(19)21-11)13(15(12)32(20,29)30)16-23-25-26-24-16/h2-6,8H,7,18H2,1H3,(H2,19,21)(H2,20,29,30)/b10-9+/t8-/m1/s1 JQZLNDUJNSGDHA-KGSKPCQNSA-N 368090 3-(2-amino-3H-benzo[d]imidazol-4-yl)-6-((R)-1-aminopropan-2-ylsulfonyl)-2-(2H-tetrazol-5-yl)benzenesulfonamide::US10227331, Example 277 Metallo-beta-lactamase type 2 1.37 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368090 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368090&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135149911 402364945 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727195 C[C@@H](CN)S(=O)(=O)c1ccc(-c2cccc3nc(N)[nH]c23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C17H17N9O4S2/c1-8(7-18)31(27,28)12-6-5-9(10-3-2-4-11-14(10)22-17(19)21-11)13(15(12)32(20,29)30)16-23-25-26-24-16/h2-6,8H,7,18H2,1H3,(H2,19,21)(H2,20,29,30)/b10-9+/t8-/m0/s1 JQZLNDUJNSGDHA-VPOJCXOPSA-N 368091 3-(2-amino-3H-benzo[d]imidazol-4-yl)-6-((S)-1-aminopropan-2-ylsulfonyl)-2-(2H-tetrazol-5-yl)benzenesulfonamide::US10227331, Example 278 Metallo-beta-lactamase type 2 1.42 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368091 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368091&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135149704 402364946 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727198 C[C@H](CN)S(=O)(=O)c1ccc(-c2cccc3n(C)c(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O 368092 3-(2-amino-1-methyl-1H-benzo[d]imidazol-4-yl)-6-((R)-1-aminopropan-2-ylsulfonyl)-2-(2H-tetrazol-5-yl)benzenesulfonamide::US10227331, Example 279 Metallo-beta-lactamase type 2 0.695 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368092 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368092&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124159677 402364947 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727363 NCCS(=O)(=O)c1ccc(-c2cccc(NC(=O)[C@H](N)CO)c2)c(-c2nn[nH]n2)c1S(N)(=O)=O 368147 (R)-2-amino-N-(4'-((2- aminoethyl)sulfonyl)- 3'-sulfamoyl-2'-(2H- tetrazol-5-yl)-[1,1'- biphenyl]-3-yl)-3- hydroxypropanamide::US10227331, Example 334 Metallo-beta-lactamase type 2 4.54 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368147 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368147&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 145713741 402364997 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727366 NCCS(=O)(=O)c1ccc(-c2cnc(N)c(c2)C(N)=O)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C15H17N9O5S2/c16-3-4-30(26,27)10-2-1-8(7-5-9(14(18)25)13(17)20-6-7)11(12(10)31(19,28)29)15-21-23-24-22-15/h1-2,5-6H,3-4,16H2,(H2,17,20)(H2,18,25)(H2,19,28,29)(H,21,22,23,24) CJRKCZJDOVBBMX-UHFFFAOYSA-N 368148 2-Amino-5-(4-((2-aminoethyl)sulfonyl)-3-sulfamoyl-2-(2H-tetrazol-5-yl)phenyl)nicotinamide::US10227331, Example 335 Metallo-beta-lactamase type 2 8.90 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368148 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368148&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 145713742 402364998 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727369 NCCS(=O)(=O)c1ccc(-c2cnc(N)c(c2)C(=O)N[C@H]2CCNC2)c(-c2nn[nH]n2)c1S(N)(=O)=O 368149 (S)-2-Amino-5-(4-((2-aminoethyl)sulfonyl)-3-sulfamoyl-2-(2H-tetrazol-5-yl)phenyl)-N-(pyrrolidin-3-yl)nicotinamide::US10227331, Example 336 Metallo-beta-lactamase type 2 9.51 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368149 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368149&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 145713743 402364999 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727372 NCCNC(=O)c1cc(cnc1N)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)CCN InChI=1S/C17H22N10O5S2/c18-3-5-22-17(28)11-7-9(8-23-15(11)20)10-1-2-12(33(29,30)6-4-19)14(34(21,31)32)13(10)16-24-26-27-25-16/h1-2,7-8H,3-6,18-19H2,(H2,20,23)(H,22,28)(H2,21,31,32)(H,24,25,26,27) SIBZBMBDSYIQCH-UHFFFAOYSA-N 368150 2-amino-N-(2- aminoethyl)-5- (4-((2-aminoethyl) sulfonyl)-3-sulfamoyl- 2-(2H-tetrazol-5-yl) phenyl)nicotinamide::US10227331, Example 337 Metallo-beta-lactamase type 2 12.3 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368150 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368150&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 145713744 402365000 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726469 Nc1ccc2cccc(-c3ccc(c(c3-c3nn[nH]n3)S(N)(=O)=O)S(=O)(=O)C3CNC3)c2n1 InChI=1S/C19H18N8O4S2/c20-15-7-4-10-2-1-3-13(17(10)23-15)12-5-6-14(32(28,29)11-8-22-9-11)18(33(21,30)31)16(12)19-24-26-27-25-19/h1-7,11,22H,8-9H2,(H2,20,23)(H2,21,30,31)(H,24,25,26,27) MBAMLCSMXVPBFG-UHFFFAOYSA-N 367849 3-(2-aminoquinolin-8-yl)-6- (azetidin-3-ylsulfonyl)-2- (2H-tetrazol-5- yl)benzenesulfonamide::US10227331, Example 36 Metallo-beta-lactamase type 2 0.357 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367849 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367849&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 145713665 402364709 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726472 Nc1nc2c(cccc2c(=O)[nH]1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)C1CNC1 InChI=1S/C18H17N9O5S2/c19-18-22-14-10(2-1-3-11(14)17(28)23-18)9-4-5-12(33(29,30)8-6-21-7-8)15(34(20,31)32)13(9)16-24-26-27-25-16/h1-5,8,21H,6-7H2,(H2,20,31,32)(H3,19,22,23,28)(H,24,25,26,27) XKJNWLOSHLZVDR-UHFFFAOYSA-N 367850 3-(2-amino-4-oxo-3,4- dihydroquinazolin-8-yl)-6- (azetidin-3-ylsulfonyl)-2- (2H-tetrazol-5- yl)benzenesulfonamide::US10227331, Example 37 Metallo-beta-lactamase type 2 1.90 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367850 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367850&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 145713666 402364710 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726475 Nc1nc2c(ccc(C(O)=O)c2s1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)C1CNC1 InChI=1S/C18H16N8O6S3/c19-18-22-13-9(1-2-10(17(27)28)14(13)33-18)8-3-4-11(34(29,30)7-5-21-6-7)15(35(20,31)32)12(8)16-23-25-26-24-16/h1-4,7,21H,5-6H2,(H2,19,22)(H,27,28)(H2,20,31,32)(H,23,24,25,26) ZPHNUQZFJFUCHA-UHFFFAOYSA-N 367851 2-amino-4-(4-(azetidin-3-ylsulfonyl)-3-sulfamoyl-2-(2H-tetrazol-5-yl)phenyl)benzo[d]thiazole-7-carboxylic Acid::US10227331, Example 38 Metallo-beta-lactamase type 2 0.126 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367851 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367851&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 145713667 402364711 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726478 NC(=O)c1ccc(-c2ccc(c(c2-c2nn[nH]n2)S(N)(=O)=O)S(=O)(=O)C2CNC2)c2nc(N)sc12 InChI=1S/C18H17N9O5S3/c19-16(28)10-2-1-9(13-14(10)33-18(20)23-13)8-3-4-11(34(29,30)7-5-22-6-7)15(35(21,31)32)12(8)17-24-26-27-25-17/h1-4,7,22H,5-6H2,(H2,19,28)(H2,20,23)(H2,21,31,32)(H,24,25,26,27) PSYAIYVBWNAVRQ-UHFFFAOYSA-N 367852 2-amino-4-(4-(azetidin-3-ylsulfonyl)-3-sulfamoyl-2-(2H-tetrazol-5-yl)phenyl)benzo[d]thiazole-7-carboxamide::US10227331, Example 39 Metallo-beta-lactamase type 2 0.276 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367852 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367852&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124157575 402364712 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726481 Nc1nc2cc(ccc2[nH]1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)C1CNC1 InChI=1S/C17H17N9O4S2/c18-17-21-11-3-1-8(5-12(11)22-17)10-2-4-13(31(27,28)9-6-20-7-9)15(32(19,29)30)14(10)16-23-25-26-24-16/h1-5,9,20H,6-7H2,(H3,18,21,22)(H2,19,29,30)(H,23,24,25,26) WMXQDXWTVRWPCX-UHFFFAOYSA-N 367853 3-(2-amino-1H-benzo[d]imidazol-5-yl)-6-(azetidin-3-ylsulfonyl)-2-(2H-tetrazol-5-yl)benzenesulfonamide::US10227331, Example 40 Metallo-beta-lactamase type 2 1.99 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367853 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367853&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124157276 402364713 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726697 Nc1cncc(c1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)C1CNC1 InChI=1S/C15H16N8O4S2/c16-9-3-8(4-18-5-9)11-1-2-12(28(24,25)10-6-19-7-10)14(29(17,26)27)13(11)15-20-22-23-21-15/h1-5,10,19H,6-7,16H2,(H2,17,26,27)(H,20,21,22,23) HDRPLWXNPSIELR-UHFFFAOYSA-N 367925 3-((4-(5-aminopyridin-3- yl)-2-sulfamoyl-3-(1H- tetrazol-5- yl)phenyl)sulfonyl)azetidin- 1-ium 2,2,2- trifluoroacetate::US10227331, Example 112 Metallo-beta-lactamase type 2 8.68 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367925 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367925&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135150024 402364785 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726700 NS(=O)(=O)c1c(ccc(-c2cccc3C(=O)NCc23)c1-c1nnn[nH]1)S(=O)(=O)C1CNC1 InChI=1S/C18H17N7O5S2/c19-32(29,30)16-14(31(27,28)9-6-20-7-9)5-4-11(15(16)17-22-24-25-23-17)10-2-1-3-12-13(10)8-21-18(12)26/h1-5,9,20H,6-8H2,(H,21,26)(H2,19,29,30)(H,22,23,24,25) GQGAVJZBXQWLHQ-UHFFFAOYSA-N 367926 3-((4-(1-oxoisoindolin-4- yl)-2-sulfamoyl-3-(1H- tetrazol-5- yl)phenyl)sulfonyl)azetidin- 1-ium 2,2,2- trifluoroacetate::US10227331, Example 113 Metallo-beta-lactamase type 2 6.06 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367926 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367926&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135149754 402364786 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726703 NS(=O)(=O)c1c(ccc(-c2ccc3scnc3c2)c1-c1nnn[nH]1)S(=O)(=O)C1CNC1 InChI=1S/C17H15N7O4S3/c18-31(27,28)16-14(30(25,26)10-6-19-7-10)4-2-11(15(16)17-21-23-24-22-17)9-1-3-13-12(5-9)20-8-29-13/h1-5,8,10,19H,6-7H2,(H2,18,27,28)(H,21,22,23,24) VOLILWYXCLWYSU-UHFFFAOYSA-N 367927 3-((4-(benzo[d]thiazol-5- yl)-2-sulfamoyl-3-(1H- tetrazol-5- yl)phenyl)sulfonyl)azetidin- 1-ium 2,2,2- trifluoroacetate::US10227331, Example 114 Metallo-beta-lactamase type 2 0.261 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367927 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367927&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135149920 402364787 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726706 NS(=O)(=O)c1c(ccc(-c2ccc3ncccc3c2)c1-c1nnn[nH]1)S(=O)(=O)C1CNC1 InChI=1S/C19H17N7O4S2/c20-32(29,30)18-16(31(27,28)13-9-21-10-13)6-4-14(17(18)19-23-25-26-24-19)11-3-5-15-12(8-11)2-1-7-22-15/h1-8,13,21H,9-10H2,(H2,20,29,30)(H,23,24,25,26) RQWLFXXWNLOPNS-UHFFFAOYSA-N 367928 3-((4-(quinolin-6-yl)-2- sulfamoyl-3-(1H- tetrazol-5- yl)phenyl)sulfonyl)azetidin- 1-ium 2,2,2- trifluoroacetate::US10227331, Example 115 Metallo-beta-lactamase type 2 0.793 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367928 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367928&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135149714 402364788 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726709 NS(=O)(=O)c1c(ccc(-c2ccc3cnccc3c2)c1-c1nnn[nH]1)S(=O)(=O)C1CNC1 InChI=1S/C19H17N7O4S2/c20-32(29,30)18-16(31(27,28)14-9-22-10-14)4-3-15(17(18)19-23-25-26-24-19)12-1-2-13-8-21-6-5-11(13)7-12/h1-8,14,22H,9-10H2,(H2,20,29,30)(H,23,24,25,26) XYVYPUUEQBLMFB-UHFFFAOYSA-N 367929 3-((4-(isoquinolin-6-yl)- 2-sulfamoyl-3-(1H- tetrazol-5- yl)phenyl)sulfonyl)azetidin- 1-ium 2,2,2- trifluoroacetate::US10227331, Example 116 Metallo-beta-lactamase type 2 0.722 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367929 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367929&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135150036 402364789 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726889 N[C@H]1C[C@@H](C1)S(=O)(=O)c1ccc(-c2cccc3nc(N)[nH]c23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C18H17N9O4S2/c19-8-6-9(7-8)32(28,29)13-5-4-10(11-2-1-3-12-15(11)23-18(20)22-12)14(16(13)33(21,30)31)17-24-26-27-25-17/h1-5,8-9H,6-7,19H2,(H2,20,22)(H2,21,30,31)/b11-10+/t8-,9- OAECODSJNPAUFS-RGESTZRMSA-N 367988 3-(2-amino-3H-benzo[d]imidazol-4-yl)-6-((1r,3r)-3-aminocyclobutylsulfonyl)-2-(2H-tetrazol-5-yl)benzenesulfonamide and 3-(2-amino-3H-benzo[d]imidazol-4-yl)-6-((1s, 3s)-3-aminocyclobutylsulfonyl)-2-(2H-tetrazol-5-yl)benzenesulfonamide::US10227331, Example 175::US10227331, Example 176 Metallo-beta-lactamase type 2 1.09 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367988 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367988&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135149758 402364848 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726892 N[C@H]1CC[C@H](CC1)S(=O)(=O)c1ccc(-c2cccc3nc(N)[nH]c23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C20H21N9O4S2/c21-10-4-6-11(7-5-10)34(30,31)15-9-8-12(13-2-1-3-14-17(13)25-20(22)24-14)16(18(15)35(23,32)33)19-26-28-29-27-19/h1-3,8-11H,4-7,21H2,(H2,22,24)(H2,23,32,33)/b13-12+/t10-,11+ ZDYRFLYMUVGJBS-VHYQIFHASA-N 367990 3-(2-amino-3H- benzo[d]imidazol-4-yl)-6- ((1s,4s)-4- aminocyclohexylsulfonyl)-2- (2H-tetrazol-5- yl)benzenesulfonamide::US10227331, Example 177 Metallo-beta-lactamase type 2 1.35 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367990 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367990&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135149894 402364849 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726895 N[C@H]1CC[C@@H](CC1)S(=O)(=O)c1ccc(-c2cccc3nc(N)[nH]c23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C20H21N9O4S2/c21-10-4-6-11(7-5-10)34(30,31)15-9-8-12(13-2-1-3-14-17(13)25-20(22)24-14)16(18(15)35(23,32)33)19-26-28-29-27-19/h1-3,8-11H,4-7,21H2,(H2,22,24)(H2,23,32,33)/b13-12+/t10-,11- ZDYRFLYMUVGJBS-KRVZQXBDSA-N 367991 3-(2-amino-3H- benzo[d]imidazol-4-yl)-6- ((1r,4r)-4- aminocyclohexylsulfonyl)-2- (2H-tetrazol-5- yl)benzenesulfonamide::US10227331, Example 178 Metallo-beta-lactamase type 2 0.990 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367991 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367991&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135149894 402364850 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726898 N[C@H]1C[C@@H](C1)S(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O 367992 3-(2-aminobenzo[d]thiazol-4- yl)-6-((1r,3r-3- aminocyclobutylsulfonyl)-2- (2H-tetrazol-5- yl)benzenesulfonamide::US10227331, Example 179 Metallo-beta-lactamase type 2 0.135 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367992 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367992&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135149502 402364851 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726916 NS(=O)(=O)c1c(ccc(-c2cccc3cn[nH]c23)c1-c1nn[nH]n1)S(=O)(=O)[C@@H]1CCNC1 InChI=1S/C18H16N8O4S2/c19-32(29,30)17-14(31(27,28)11-6-7-20-9-11)5-4-12(15(17)18-23-25-26-24-18)13-3-1-2-10-8-21-22-16(10)13/h1-5,8,11,20H,6-7,9H2,(H2,19,29,30)/b13-12+/t11-/m1/s1 JKJOKOZIDVFGPT-GXZRWPEMSA-N 367998 3-(1H-indazol-7-yl)-6-((R)- pyrrolidin-3-ylsulfonyl)-2-(2H- tetrazol-5- yl)benzenesulfonamide::US10227331, Example 185 Metallo-beta-lactamase type 2 0.466 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367998 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367998&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135149520 402364857 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726919 NS(=O)(=O)c1c(ccc(-c2cccc3cn[nH]c23)c1-c1nn[nH]n1)S(=O)(=O)[C@H]1CCNC1 InChI=1S/C18H16N8O4S2/c19-32(29,30)17-14(31(27,28)11-6-7-20-9-11)5-4-12(15(17)18-23-25-26-24-18)13-3-1-2-10-8-21-22-16(10)13/h1-5,8,11,20H,6-7,9H2,(H2,19,29,30)/b13-12+/t11-/m0/s1 JKJOKOZIDVFGPT-UMAGAQSHSA-N 367999 3-(1H-indazol-7-yl)-6-((S)- pyrrolidin-3-ylsulfonyl)-2-(2H- tetrazol-5- yl)benzenesulfonamide::US10227331, Example 186 Metallo-beta-lactamase type 2 0.541 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367999 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367999&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135150100 402364858 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726922 Cc1ccc(-c2ccc(c(c2-c2nn[nH]n2)S(N)(=O)=O)S(=O)(=O)[C@@H]2CCNC2)c2nc(N)sc12 368000 3-(2-amino-7- methylbenzo[d]thiazol-4-yl)-6- ((R)-pyrrolidin-3-ylsulfonyl)-2- (2H-tetrazol-5- yl)benzenesulfonamide::US10227331, Example 187 Metallo-beta-lactamase type 2 0.076 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368000 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368000&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135149569 402364859 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726925 Cc1ccc(-c2ccc(c(c2-c2nn[nH]n2)S(N)(=O)=O)S(=O)(=O)[C@H]2CCNC2)c2nc(N)sc12 368001 3-(2-amino-7- methylbenzo[d]thiazol-4-yl)-6- ((S)-pyrrolidin-3-ylsulfonyl)-2- (2H-tetrazol-5- yl)benzenesulfonamide::US10227331, Example 188 Metallo-beta-lactamase type 2 0.109 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368001 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368001&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135150186 402364860 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726985 N[C@H]1CC[C@H](CC1)c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)C1CCNCC1 368021 3-((1s,4s)-4- aminocyclohexyl)-6- (piperidin-4-ylsulfonyl)-2- (1H-tetrazol-5-yl) benzenesulfonamide::US10227331, Example 208 Metallo-beta-lactamase type 2 124 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368021 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368021&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135149633 402364880 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726988 CS(=O)(=O)c1ccc([C@@H]2CC[C@H](N)CC2)c(-c2nnn[nH]2)c1S(N)(=O)=O 368022 3-((1s,4s)-4- aminocyclohexyl)-6- (methylsulfonyl)-2-(1H- tetrazol-5-yl) benzenesulfonamide::US10227331, Example 209 Metallo-beta-lactamase type 2 65.3 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368022 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368022&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135149602 402364881 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726991 CS(=O)(=O)c1ccc([C@H]2CC[C@H](N)CC2)c(-c2nnn[nH]2)c1S(N)(=O)=O 368023 3-((1r,4r)-4- aminocyclohexyl)-6- (methylsulfonyl)-2-(1H- tetrazol-5-yl) benzenesulfonamide::US10227331, Example 210 Metallo-beta-lactamase type 2 7.76 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368023 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368023&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135149602 402364882 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726994 CCCS(=O)(=O)c1ccc(C2=CCC(N)CC2)c(-c2nnn[nH]2)c1S(N)(=O)=O 368024 4'-amino-4- (propylsulfonyl)-2-(1H- tetrazol-5-yl)-2',3',4',5'- tetrahydro-[1,1'-biphenyl]- 3-sulfonamide::US10227331, Example 211 Metallo-beta-lactamase type 2 6.32 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368024 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368024&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135149774 402364883 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727042 NS(=O)(=O)c1c(ccc(-c2ccc(cc2)C2CCNCC2)c1-c1nnn[nH]1)S(=O)C1CCNCC1 368040 4′-(piperidin-4-yl)-4-(piperidin-4-ylsulfinyl)-2-(1H-tetrazol-5-yl)-[1,1′-biphenyl]-3-sulfonamide::US10227331, Example 227 Metallo-beta-lactamase type 2 5.90 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368040 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368040&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 145713696 402364899 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727045 NS(=O)(=O)c1c(ccc(-c2ccc(cc2)C2CCNCC2)c1-c1nnn[nH]1)S(=O)(=O)C1CCNCC1 InChI=1S/C23H29N7O4S2/c24-36(33,34)22-20(35(31,32)18-9-13-26-14-10-18)6-5-19(21(22)23-27-29-30-28-23)17-3-1-15(2-4-17)16-7-11-25-12-8-16/h1-6,16,18,25-26H,7-14H2,(H2,24,33,34)(H,27,28,29,30) MMQDOCFJJIBSMW-UHFFFAOYSA-N 368041 4′-(piperidin-4-yl)-4-(piperidin-4-ylsulfonyl)-2-(1H-tetrazol-5-yl)-[1,1′-biphenyl]-3-sulfonamide::US10227331, Example 228 Metallo-beta-lactamase type 2 0.521 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368041 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368041&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 145713697 402364900 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727048 COc1ccc(Cc2cc3c(cccc3n2C)-c2ccc(c(c2-c2nnn[nH]2)S(N)(=O)=O)S(=O)(=O)C2CNC2)cc1 InChI=1S/C27H27N7O5S2/c1-34-17(12-16-6-8-18(39-2)9-7-16)13-22-20(4-3-5-23(22)34)21-10-11-24(40(35,36)19-14-29-15-19)26(41(28,37)38)25(21)27-30-32-33-31-27/h3-11,13,19,29H,12,14-15H2,1-2H3,(H2,28,37,38)(H,30,31,32,33) LSHYTYHPKFOCBP-UHFFFAOYSA-N 368042 6-(azetidin-3-ylsulfonyl)-3-(1-methyl-3-(2,2,2-trifluoroacetyl)-1H-indol-4-yl)-2-(1H-tetrazol-5-yl)benzenesulfonamide and 6-(azetidin-3-ylsulfonyl)-3-(2-(4-methoxybenzyl)-1-methyl-1H-indol-4-yl)-2-(1H-tetrazol-5-yl)benzenesulfonamide::US10227331, Example 229::US10227331, Example 230 Metallo-beta-lactamase type 2 1.73 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368042 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368042&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 145713698 402364901 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727201 C[C@@H](CN)S(=O)(=O)c1ccc(-c2cccc3n(C)c(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O 368093 3-(2-amino-1-methyl-1H-benzo[d]imidazol-4-yl)-6-((S)-1-aminopropan-2-ylsulfonyl)-2-(2H-tetrazol-5-yl)benzenesulfonamide::US10227331, Example 280 Metallo-beta-lactamase type 2 0.954 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368093 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368093&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124159685 402364948 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727204 NC[C@H](O)CS(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O 368094 6-((S)-3-amino-2-hydroxypropylsulfonyl)-3-(2-aminobenzo[d]thiazol-4-yl)-2-(2H-tetrazol-5-yl)benzenesulfonamide::US10227331, Example 281 Metallo-beta-lactamase type 2 0.126 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368094 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368094&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124159694 402364949 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727207 NC[C@H](O)CS(=O)(=O)c1ccc(-c2cccc3[nH]c(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C17H17N9O5S2/c18-6-8(27)7-32(28,29)12-5-4-9(10-2-1-3-11-14(10)22-17(19)21-11)13(15(12)33(20,30)31)16-23-25-26-24-16/h1-5,8,27H,6-7,18H2,(H2,19,21)(H2,20,30,31)/b10-9+/t8-/m0/s1 JZRMNEHCCUZTST-VPOJCXOPSA-N 368095 3-(2-amino-1H-benzo[d]imidazol-4-yl)-6-((S)-3-amino-2-hydroxypropyl sulfonyl)-2-(2H-tetrazol-5-yl)benzenesulfonamide::US10227331, Example 282 Metallo-beta-lactamase type 2 0.777 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368095 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368095&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124159661 402364950 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727210 CCn1c(N)nc2c(cccc12)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)C1CNC1 InChI=1S/C19H21N9O4S2/c1-2-28-13-5-3-4-12(16(13)23-19(28)20)11-6-7-14(33(29,30)10-8-22-9-10)17(34(21,31)32)15(11)18-24-26-27-25-18/h3-7,10,22H,2,8-9H2,1H3,(H2,20,23)(H2,21,31,32)(H,24,25,26,27) LIJLSOCXIPROGL-UHFFFAOYSA-N 368096 3-(2-amino-1-ethyl-1H-benzo[d]imidazol-4-yl)-6-(azetidin-3-ylsulfonyl)-2-(2H-tetrazol-5-yl)benzenesulfonamide::US10227331, Example 283 Metallo-beta-lactamase type 2 0.496 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368096 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368096&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135149822 402364951 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727375 NCCS(=O)(=O)c1ccc(-c2cccc(NC(=O)CN)c2NC(=O)CN)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C19H24N10O6S2/c20-6-7-36(32,33)13-5-4-10(16(18(13)37(23,34)35)19-26-28-29-27-19)11-2-1-3-12(24-14(30)8-21)17(11)25-15(31)9-22/h1-5H,6-9,20-22H2,(H,24,30)(H,25,31)(H2,23,34,35)(H,26,27,28,29) FSCKKPJCMCDRPF-UHFFFAOYSA-N 368151 N,N′-(4′-((2-Aminoethyl)sulfonyl)-3′-sulfamoyl-2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-2,3-diyl)bis(2-aminoacetamide)::US10227331, Example 338 Metallo-beta-lactamase type 2 74.9 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368151 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368151&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 145713745 402365001 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727378 NCCS(=O)(=O)c1ccc(-c2ccccc2N)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C15H17N7O4S2/c16-7-8-27(23,24)12-6-5-10(9-3-1-2-4-11(9)17)13(14(12)28(18,25)26)15-19-21-22-20-15/h1-6H,7-8,16-17H2,(H2,18,25,26)(H,19,20,21,22) MFBBAPYAHPJTGB-UHFFFAOYSA-N 368152 2′-Amino-4-((2-aminoethyl)sulfonyl)-2-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-3-sulfonamide::US10227331, Example 339 Metallo-beta-lactamase type 2 3.42 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368152 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368152&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 145713746 402365002 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727381 NCCS(=O)(=O)c1ccc(-c2ccccc2NC(=O)CN)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C17H20N8O5S2/c18-7-8-31(27,28)13-6-5-11(10-3-1-2-4-12(10)21-14(26)9-19)15(16(13)32(20,29)30)17-22-24-25-23-17/h1-6H,7-9,18-19H2,(H,21,26)(H2,20,29,30)(H,22,23,24,25) HPARQMCMBQNQGB-UHFFFAOYSA-N 368153 2-Amino-N-(4′-((2-aminoethyl)sulfonyl)-3′-sulfamoyl-2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-2-yl)acetamide::US10227331, Example 340 Metallo-beta-lactamase type 2 107 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368153 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368153&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 145713747 402365003 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727384 COC(=O)c1cccc(c1NCCN)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)CCN InChI=1S/C19H24N8O6S2/c1-33-19(28)13-4-2-3-12(16(13)23-9-7-20)11-5-6-14(34(29,30)10-8-21)17(35(22,31)32)15(11)18-24-26-27-25-18/h2-6,23H,7-10,20-21H2,1H3,(H2,22,31,32)(H,24,25,26,27) PAEWQUVCCPOTMB-UHFFFAOYSA-N 368154 Methyl 2-((2-aminoethyl)amino)-4′-((2-aminoethyl)sulfonyl)-3′-sulfamoyl-2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-3-carboxylate::US10227331, Example 341 Metallo-beta-lactamase type 2 16.1 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368154 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368154&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135149778 402365004 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726484 Nc1nc2ccc(cc2[nH]1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)C1CCNCC1 InChI=1S/C19H21N9O4S2/c20-19-23-13-3-1-10(9-14(13)24-19)12-2-4-15(33(29,30)11-5-7-22-8-6-11)17(34(21,31)32)16(12)18-25-27-28-26-18/h1-4,9,11,22H,5-8H2,(H3,20,23,24)(H2,21,31,32)(H,25,26,27,28) PNRBCPLTLJCAJE-UHFFFAOYSA-N 367854 3-(2-amino-3H- benzo[d]imidazol-5-yl)-6- (piperidin-4-ylsulfonyl)-2- (2H-tetrazol-5- yl)benzenesulfonamide::US10227331, Example 41 Metallo-beta-lactamase type 2 3.51 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367854 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367854&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 145713668 402364714 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726487 Nc1nc2cccc(-c3ccc(c(c3-c3nn[nH]n3)S(N)(=O)=O)S(=O)(=O)C3CCNCC3)c2[nH]1 InChI=1S/C19H21N9O4S2/c20-19-23-13-3-1-2-12(16(13)24-19)11-4-5-14(33(29,30)10-6-8-22-9-7-10)17(34(21,31)32)15(11)18-25-27-28-26-18/h1-5,10,22H,6-9H2,(H3,20,23,24)(H2,21,31,32)(H,25,26,27,28) LFMITPFALIEONG-UHFFFAOYSA-N 367855 3-(2-amino-3H-benzo[d]imidazol-4-yl)-6-(piperidin-4-ylsulfonyl)-2-(2H-tetrazol-5-yl)benzenesulfonamide::US10227331, Example 42 Metallo-beta-lactamase type 2 1.19 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367855 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367855&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124157483 402364715 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726490 Nc1nc2c(cccc2[nH]1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)C1CNC1 InChI=1S/C17H17N9O4S2/c18-17-21-11-3-1-2-10(14(11)22-17)9-4-5-12(31(27,28)8-6-20-7-8)15(32(19,29)30)13(9)16-23-25-26-24-16/h1-5,8,20H,6-7H2,(H3,18,21,22)(H2,19,29,30)(H,23,24,25,26) JNQIEVJDVWORER-UHFFFAOYSA-N 367856 3-(2-amino-1H- benzo[d]imidazol-4-yl)-6- (azetidin-3-ylsulfonyl)-2-(2H- tetrazol-5- yl)benzenesulfonamide::US10227331, Example 43 Metallo-beta-lactamase type 2 0.828 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367856 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367856&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 145713669 402364716 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726493 CC(=O)N1CCC(CC1)S(=O)(=O)c1ccc(-c2cccc3nc(N)[nH]c23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C21H23N9O5S2/c1-11(31)30-9-7-12(8-10-30)36(32,33)16-6-5-13(14-3-2-4-15-18(14)25-21(22)24-15)17(19(16)37(23,34)35)20-26-28-29-27-20/h2-6,12H,7-10H2,1H3,(H3,22,24,25)(H2,23,34,35)(H,26,27,28,29) ZKOYIAZOVKIQDC-UHFFFAOYSA-N 367857 6-(1-acetylpiperidin-4-ylsulfonyl)-3-(2-amino-3H-benzo[d]imidazol-4-yl)-2-(2H-tetrazol-5-yl)benzenesulfonamide::US10227331, Example 44 Metallo-beta-lactamase type 2 1.98 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367857 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367857&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135149914 402364717 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726496 CS(=O)(=O)N1CCC(CC1)S(=O)(=O)c1ccc(-c2cccc3nc(N)[nH]c23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C20H23N9O6S3/c1-36(30,31)29-9-7-11(8-10-29)37(32,33)15-6-5-12(13-3-2-4-14-17(13)24-20(21)23-14)16(18(15)38(22,34)35)19-25-27-28-26-19/h2-6,11H,7-10H2,1H3,(H3,21,23,24)(H2,22,34,35)(H,25,26,27,28) URWJAEFBDOHZMD-UHFFFAOYSA-N 367858 3-(2-amino-3H-benzo[d]imidazol-4-yl)-6- (1-(methylsulfonyl)piperidin-4- ylsulfonyl)-2-(2H-tetrazol-5- yl)benzenesulfonamide::US10227331, Example 45 Metallo-beta-lactamase type 2 1.69 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367858 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367858&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 145713670 402364718 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726499 CCOC(=O)N1CCC(CC1)S(=O)(=O)c1ccc(-c2cccc3nc(N)[nH]c23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C22H25N9O6S2/c1-2-37-22(32)31-10-8-12(9-11-31)38(33,34)16-7-6-13(14-4-3-5-15-18(14)26-21(23)25-15)17(19(16)39(24,35)36)20-27-29-30-28-20/h3-7,12H,2,8-11H2,1H3,(H3,23,25,26)(H2,24,35,36)(H,27,28,29,30) UWJUKJFWDWZKNJ-UHFFFAOYSA-N 367859 US10227331, Example 46::ethyl 4-(4-(2-amino-3H- benzo[d]imidazol-4-yl)-2-sulfamoyl-3- (2H-tetrazol-5- yl)phenylsulfonyl)piperidine-1- carboxylate Metallo-beta-lactamase type 2 2.15 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367859 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367859&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 145713671 402364719 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726712 NS(=O)(=O)c1c(ccc(-c2ccc3nccnc3c2)c1-c1nnn[nH]1)S(=O)(=O)C1CNC1 InChI=1S/C18H16N8O4S2/c19-32(29,30)17-15(31(27,28)11-8-20-9-11)4-2-12(16(17)18-23-25-26-24-18)10-1-3-13-14(7-10)22-6-5-21-13/h1-7,11,20H,8-9H2,(H2,19,29,30)(H,23,24,25,26) XQZTUVUFDHASMV-UHFFFAOYSA-N 367930 3-((4-(quinoxalin-6-yl)- 2-sulfamoyl-3-(1H- tetrazol-5- yl)phenyl)sulfonyl)azetidin- 1-ium 2,2,2- trifluoroacetate::US10227331, Example 117 Metallo-beta-lactamase type 2 1.41 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367930 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367930&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135149518 402364790 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726715 NS(=O)(=O)c1c(ccc(-c2cccc3ncccc23)c1-c1nnn[nH]1)S(=O)(=O)C1CNC1 InChI=1S/C19H17N7O4S2/c20-32(29,30)18-16(31(27,28)11-9-21-10-11)7-6-14(17(18)19-23-25-26-24-19)12-3-1-5-15-13(12)4-2-8-22-15/h1-8,11,21H,9-10H2,(H2,20,29,30)(H,23,24,25,26) RJHICXNQMHZNBN-UHFFFAOYSA-N 367931 3-((4-(quinolin-5-yl)-2- sulfamoyl-3-(1H- tetrazol-5- yl)phenyl)sulfonyl)azetidin- 1-ium 2,2,2- trifluoroacetate::US10227331, Example 118 Metallo-beta-lactamase type 2 1.42 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367931 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367931&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135150082 402364791 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726718 Cn1nnc2ccc(cc12)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)C1CNC1 InChI=1S/C17H17N9O4S2/c1-26-13-6-9(2-4-12(13)20-25-26)11-3-5-14(31(27,28)10-7-19-8-10)16(32(18,29)30)15(11)17-21-23-24-22-17/h2-6,10,19H,7-8H2,1H3,(H2,18,29,30)(H,21,22,23,24) KMVMTDBEPRODBS-UHFFFAOYSA-N 367932 3-((4-(1-methyl-1H- benzo[d][1,2,3]triazol-6- yl)-2-sulfamoyl-3-(1H- tetrazol-5- yl)phenyl)sulfonyl)azetidin- 1-ium 2,2,2- trifluoroacetate::US10227331, Example 119 Metallo-beta-lactamase type 2 5.74 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367932 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367932&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135149951 402364792 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726721 NS(=O)(=O)c1c(ccc(-c2csc(n2)N2CCCC2)c1-c1nnn[nH]1)S(=O)(=O)C1CNC1 InChI=1S/C17H20N8O4S3/c18-32(28,29)15-13(31(26,27)10-7-19-8-10)4-3-11(14(15)16-21-23-24-22-16)12-9-30-17(20-12)25-5-1-2-6-25/h3-4,9-10,19H,1-2,5-8H2,(H2,18,28,29)(H,21,22,23,24) IQRNHHQWKJNGMJ-UHFFFAOYSA-N 367933 3-((4-(2-(pyrrolidin-1- yl)thiazol-4-yl)-2- sulfamoyl-3-(1H- tetrazol-5- yl)phenyl)sulfonyl)azetidin- 1-ium 2,2,2- trifluoroacetate::US10227331, Example 120 Metallo-beta-lactamase type 2 0.553 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367933 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367933&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135149992 402364793 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726724 NS(=O)(=O)c1c(ccc(-c2cnc(s2)N2CCCC2)c1-c1nnn[nH]1)S(=O)(=O)C1CNC1 InChI=1S/C17H20N8O4S3/c18-32(28,29)15-13(31(26,27)10-7-19-8-10)4-3-11(14(15)16-21-23-24-22-16)12-9-20-17(30-12)25-5-1-2-6-25/h3-4,9-10,19H,1-2,5-8H2,(H2,18,28,29)(H,21,22,23,24) VYWLVGWHWREMOY-UHFFFAOYSA-N 367934 3-((4-(2-(pyrrolidin-1- yl)thiazol-5-yl)-2- sulfamoyl-3-(1H- tetrazol-5- yl)phenyl)sulfonyl)azetidin- 1-ium 2,2,2- trifluoroacetate::US10227331, Example 121 Metallo-beta-lactamase type 2 3.57 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367934 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367934&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135149655 402364794 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726928 Nc1nc2c(cccc2o1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)[C@@H]1CCNC1 368002 3-(2-aminobenzo[d]oxazol-4-yl)- 6-((R)-pyrrolidin-3-ylsulfonyl)- 2-(2H-tetrazol-5- yl)benzenesulfonamide::US10227331, Example 189 Metallo-beta-lactamase type 2 0.332 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368002 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368002&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135149626 402364861 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726931 Nc1cc2c(cccc2o1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)[C@H]1CCNC1 368003 3-(2-aminobenzo[d]oxazol-4-yl)- 6-((S)-pyrrolidin-3-ylsulfonyl)- 2-(2H-tetrazol-5- yl)benzenesulfonamide::US10227331, Example 190 Metallo-beta-lactamase type 2 0.352 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368003 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368003&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135165666 402364862 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726934 CS(=O)(=O)c1ccc(-c2cccc3cn[nH]c23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C15H13N7O4S2/c1-27(23,24)11-6-5-9(10-4-2-3-8-7-17-18-13(8)10)12(14(11)28(16,25)26)15-19-21-22-20-15/h2-7H,1H3,(H,17,18)(H2,16,25,26)(H,19,20,21,22) FUPJBKGVVJGFFZ-UHFFFAOYSA-N 368004 3-(1H-indazol-7-yl)-6-(methylsulfonyl)-2-(2H-tetrazol-5-yl)benzenesulfonamide::US10227331, Example 191 Metallo-beta-lactamase type 2 0.210 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368004 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368004&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124157577 402364863 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726937 Cn1c(N)nc2c(cccc12)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(C)(=O)=O InChI=1S/C16H16N8O4S2/c1-24-10-5-3-4-9(13(10)19-16(24)17)8-6-7-11(29(2,25)26)14(30(18,27)28)12(8)15-20-22-23-21-15/h3-7H,1-2H3,(H2,17,19)(H2,18,27,28)(H,20,21,22,23) RTMYSCUFEAGDLD-UHFFFAOYSA-N 368005 3-(2-amino-1-methyl-1H- benzo[d]imidazol-4-yl)-6- (methylsulfonyl)-2-(2H- tetrazol-5- yl)benzenesulfonamide::US10227331, Example 192 Metallo-beta-lactamase type 2 0.552 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368005 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368005&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135149909 402364864 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726997 N[C@H]1CC[C@@H](CC1)c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)C1CNC1 368025 3-((1r,4r)-4- aminocyclohexyl)-6- (azetidin-3-ylsulfonyl)-2- (1H-tetrazol-5-yl) benzenesulfonamide::US10227331, Example 212 Metallo-beta-lactamase type 2 30.2 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368025 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368025&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135149797 402364884 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727000 N[C@H]1CC[C@H](CC1)c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)C1CNC1 368026 3-((1s,4s)-4- aminocyclohexyl)-6- (azetidin-3-ylsulfonyl)-2- (1H-tetrazol-5-yl) benzenesulfonamide::US10227331, Example 213 Metallo-beta-lactamase type 2 68.3 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368026 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368026&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135149797 402364885 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727003 Nc1nc2cccc(-c3ccc(c(c3-c3nn[nH]n3)S(N)(=O)=O)S(=O)(=O)C3CNC3)n2n1 InChI=1S/C16H16N10O4S2/c17-16-20-12-3-1-2-10(26(12)23-16)9-4-5-11(31(27,28)8-6-19-7-8)14(32(18,29)30)13(9)15-21-24-25-22-15/h1-5,8,19H,6-7H2,(H2,17,23)(H2,18,29,30)(H,21,22,24,25) NPNGDYATYWJOSD-UHFFFAOYSA-N 368027 3-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-5-yl)-6-(azetidin-3-ylsulfonyl)-2-(2H-tetrazol-5-yl)benzenesulfonamide::US10227331, Example 214 Metallo-beta-lactamase type 2 3.32 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368027 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368027&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 145713690 402364886 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727006 Nc1nc2ccc(cn2n1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)C1CNC1 InChI=1S/C16H16N10O4S2/c17-16-20-12-4-1-8(7-26(12)23-16)10-2-3-11(31(27,28)9-5-19-6-9)14(32(18,29)30)13(10)15-21-24-25-22-15/h1-4,7,9,19H,5-6H2,(H2,17,23)(H2,18,29,30)(H,21,22,24,25) YMCKDPQJFYTFBZ-UHFFFAOYSA-N 368028 3-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-6-(azetidin-3-ylsulfonyl)-2-(2H-tetrazol-5-yl)benzenesulfonamide::US10227331, Example 215 Metallo-beta-lactamase type 2 2.19 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368028 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368028&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 145713691 402364887 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727051 COc1ccc(Cc2cc3c(cccc3n2C)-c2ccc(c(c2-c2nnn[nH]2)S(N)(=O)=O)S(=O)(=O)C2CNC2)cc1 InChI=1S/C27H27N7O5S2/c1-34-17(12-16-6-8-18(39-2)9-7-16)13-22-20(4-3-5-23(22)34)21-10-11-24(40(35,36)19-14-29-15-19)26(41(28,37)38)25(21)27-30-32-33-31-27/h3-11,13,19,29H,12,14-15H2,1-2H3,(H2,28,37,38)(H,30,31,32,33) LSHYTYHPKFOCBP-UHFFFAOYSA-N 368042 6-(azetidin-3-ylsulfonyl)-3-(1-methyl-3-(2,2,2-trifluoroacetyl)-1H-indol-4-yl)-2-(1H-tetrazol-5-yl)benzenesulfonamide and 6-(azetidin-3-ylsulfonyl)-3-(2-(4-methoxybenzyl)-1-methyl-1H-indol-4-yl)-2-(1H-tetrazol-5-yl)benzenesulfonamide::US10227331, Example 229::US10227331, Example 230 Metallo-beta-lactamase type 2 0.436 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368042 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368042&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 145713698 402364901 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727054 COc1ccc(Cc2cc3c(cccc3[nH]2)-c2ccc(c(c2-c2nnn[nH]2)S(N)(=O)=O)S(=O)(=O)C2CNC2)cc1 InChI=1S/C26H25N7O5S2/c1-38-17-7-5-15(6-8-17)11-16-12-21-19(3-2-4-22(21)29-16)20-9-10-23(39(34,35)18-13-28-14-18)25(40(27,36)37)24(20)26-30-32-33-31-26/h2-10,12,18,28-29H,11,13-14H2,1H3,(H2,27,36,37)(H,30,31,32,33) LBXZWDDTZLVOOC-UHFFFAOYSA-N 368044 6-(azetidin-3-ylsulfonyl)-3-(2-(4-methoxybenzyl)-1H-indol-4-yl)-2-(1H-tetrazol-5-yl)benzenesulfonamide::US10227331, Example 231 Metallo-beta-lactamase type 2 0.717 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368044 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368044&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 145713699 402364902 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727057 Nc1nc2c(cccc2s1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)c1ccccc1 InChI=1S/C20H15N7O4S3/c21-20-23-17-13(7-4-8-14(17)32-20)12-9-10-15(33(28,29)11-5-2-1-3-6-11)18(34(22,30)31)16(12)19-24-26-27-25-19/h1-10H,(H2,21,23)(H2,22,30,31)(H,24,25,26,27) CIDLLXYVAAOPSV-UHFFFAOYSA-N 368045 3-(2-aminobenzo[d]thiazol-4-yl)-6-(phenylsulfonyl)-2-(1H-tetrazol-5-yl)benzenesulfonamide::US10227331, Example 232 Metallo-beta-lactamase type 2 0.586 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368045 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368045&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 145713700 402364903 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727060 Nc1nc2c(cccc2s1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)c1ccccn1 InChI=1S/C19H14N8O4S3/c20-19-23-16-11(4-3-5-12(16)32-19)10-7-8-13(33(28,29)14-6-1-2-9-22-14)17(34(21,30)31)15(10)18-24-26-27-25-18/h1-9H,(H2,20,23)(H2,21,30,31)(H,24,25,26,27) YJXVSXOVOPUKHT-UHFFFAOYSA-N 368046 3-(2-aminobenzo[d]thiazol-4-yl)-6-(pyridin-2-ylsulfonyl)-2-(1H-tetrazol-5-yl)benzenesulfonamide::US10227331, Example 233 Metallo-beta-lactamase type 2 0.203 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368046 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368046&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 145713701 402364904 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727213 CCn1c(N)nc2c(cccc12)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)CCN InChI=1S/C18H21N9O4S2/c1-2-27-12-5-3-4-11(15(12)22-18(27)20)10-6-7-13(32(28,29)9-8-19)16(33(21,30)31)14(10)17-23-25-26-24-17/h3-7H,2,8-9,19H2,1H3,(H2,20,22)(H2,21,30,31)(H,23,24,25,26) NIZBAXPNSFBAAY-UHFFFAOYSA-N 368097 3-(2-amino-1-ethyl-1H-benzo[d]imidazol-4-yl)-6-(2-aminoethylsulfonyl)-2-(2H-tetrazol-5-yl)benzenesulfonamide::US10227331, Example 284 Metallo-beta-lactamase type 2 0.327 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368097 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368097&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135149891 402364952 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727216 C[C@H](CN)S(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O 368098 3-(2-aminobenzo[d]thiazol-4-yl)-6-((R)-1-aminopropan-2-ylsulfonyl)-2-(2H-tetrazol-5-yl)benzenesulfonamide::US10227331, Example 285 Metallo-beta-lactamase type 2 0.534 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368098 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368098&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124159648 402364953 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727219 C[C@@H](CN)S(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O 368099 3-(2-aminobenzo[d]thiazol-4-yl)-6-((S)-1-aminopropan-2-ylsulfonyl)-2-(2H-tetrazol-5-yl)benzenesulfonamide::US10227331, Example 286 Metallo-beta-lactamase type 2 0.323 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368099 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368099&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124159704 402364954 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727222 Nc1c(NS(=O)=O)cccc1-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)C1CNC1 InChI=1S/C16H18N8O6S3/c17-14-10(2-1-3-11(14)22-31(25)26)9-4-5-12(32(27,28)8-6-19-7-8)15(33(18,29)30)13(9)16-20-23-24-21-16/h1-5,8,19,31H,6-7,17H2,(H2,18,29,30)(H,22,25,26)(H,20,21,23,24) BIAKVCYGCAGTQP-UHFFFAOYSA-N 368100 2′-amino-4-(azetidin-3-ylsulfonyl)-2-(2H-tetrazol-5-yl)biphenyl-3,3′-disulfonamide::US10227331, Example 287 Metallo-beta-lactamase type 2 2.92 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368100 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368100&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 145713713 402364955 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727225 NCCNC(=O)c1cccc(c1N)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)C1CNC1 InChI=1S/C19H23N9O5S2/c20-6-7-24-19(29)13-3-1-2-12(16(13)21)11-4-5-14(34(30,31)10-8-23-9-10)17(35(22,32)33)15(11)18-25-27-28-26-18/h1-5,10,23H,6-9,20-21H2,(H,24,29)(H2,22,32,33)(H,25,26,27,28) XRIFBUHRYWBQAE-UHFFFAOYSA-N 368101 2-amino-N-(2-aminoethyl)-4′-(azetidin-3-ylsulfonyl)-5′-sulfamoyl-6′-(2H-tetrazol-5-yl)biphenyl-3-carboxamide::US10227331, Example 288 Metallo-beta-lactamase type 2 9.83 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368101 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368101&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124157208 402364956 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726502 Nc1nc2cccc(-c3ccc(c(c3-c3nn[nH]n3)S(N)(=O)=O)S(=O)(=O)C3CCN(CCO)CC3)c2[nH]1 InChI=1S/C21H25N9O5S2/c22-21-24-15-3-1-2-14(18(15)25-21)13-4-5-16(19(37(23,34)35)17(13)20-26-28-29-27-20)36(32,33)12-6-8-30(9-7-12)10-11-31/h1-5,12,31H,6-11H2,(H3,22,24,25)(H2,23,34,35)(H,26,27,28,29) AWNMGQRRMFPDTJ-UHFFFAOYSA-N 367860 3-(2-amino-3H-benzo[d]imidazol-4-yl)-6-(1-(2-hydroxyethyl)piperidin-4-ylsulfonyl)-2-(2H-tetrazol-5-yl)benzenesulfonamide::US10227331, Example 47 Metallo-beta-lactamase type 2 0.846 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367860 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367860&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135149599 402364720 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726505 NCCN1CCC(CC1)S(=O)(=O)c1ccc(-c2cccc3nc(N)[nH]c23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C21H26N10O4S2/c22-8-11-31-9-6-12(7-10-31)36(32,33)16-5-4-13(14-2-1-3-15-18(14)26-21(23)25-15)17(19(16)37(24,34)35)20-27-29-30-28-20/h1-5,12H,6-11,22H2,(H3,23,25,26)(H2,24,34,35)(H,27,28,29,30) HLECXURRYXJQSU-UHFFFAOYSA-N 367861 3-(2-amino-3H-benzo[d]imidazol-4-yl)-6-(1-(2-aminoethyl)piperidin-4-ylsulfonyl)-2-(2H-tetrazol-5-yl)benzenesulfonamide::US10227331, Example 48 Metallo-beta-lactamase type 2 2.30 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367861 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367861&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135150102 402364721 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726508 NC(=O)N1CCC(CC1)S(=O)(=O)c1ccc(-c2cccc3nc(N)[nH]c23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C20H22N10O5S2/c21-19-24-13-3-1-2-12(16(13)25-19)11-4-5-14(17(37(23,34)35)15(11)18-26-28-29-27-18)36(32,33)10-6-8-30(9-7-10)20(22)31/h1-5,10H,6-9H2,(H2,22,31)(H3,21,24,25)(H2,23,34,35)(H,26,27,28,29) OLNPMJLIGFZSQN-UHFFFAOYSA-N 367862 4-(4-(2-amino-3H-benzo[d]imidazol-4-yl)-2-sulfamoyl-3-(2H-tetrazol-5-yl)phenylsulfonyl)piperidine-1-carboxamide::US10227331, Example 49 Metallo-beta-lactamase type 2 1.37 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367862 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367862&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124159706 402364722 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726511 NC(=O)CN1CC(C1)S(=O)(=O)c1ccc(-c2cccc3[nH]c(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C19H20N10O5S2/c20-14(30)8-29-6-9(7-29)35(31,32)13-5-4-10(11-2-1-3-12-16(11)24-19(21)23-12)15(17(13)36(22,33)34)18-25-27-28-26-18/h1-5,9H,6-8H2,(H2,20,30)(H3,21,23,24)(H2,22,33,34)(H,25,26,27,28) PRMCFHPEWASYEA-UHFFFAOYSA-N 367863 2-(3-(4-(2-amino-1H-benzo[d]imidazol-4-yl)-2-sulfamoyl-3-(2H-tetrazol-5-yl)phenylsulfonyl)azetidin-1-yl)acetamide::US10227331, Example 50 Metallo-beta-lactamase type 2 1.44 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367863 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367863&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124157300 402364723 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726514 NCCN1CC(C1)S(=O)(=O)c1ccc(-c2cccc3[nH]c(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C19H22N10O4S2/c20-6-7-29-8-10(9-29)34(30,31)14-5-4-11(12-2-1-3-13-16(12)24-19(21)23-13)15(17(14)35(22,32)33)18-25-27-28-26-18/h1-5,10H,6-9,20H2,(H3,21,23,24)(H2,22,32,33)(H,25,26,27,28) AOOWLDAPBPQIRG-UHFFFAOYSA-N 367864 3-(2-amino-1H- benzo[d]imidazol-4-yl)-6-(1-(2- aminoethyl)azetidin-3- ylsulfonyl)-2-(2H-tetrazol-5- yl)benzenesulfonamide::US10227331, Example 51 Metallo-beta-lactamase type 2 1.31 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367864 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367864&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 145713672 402364724 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726727 Cc1ccc2cccc(-c3ccc(c(c3-c3nnn[nH]3)S(N)(=O)=O)S(=O)(=O)C3CNC3)c2n1 InChI=1S/C20H19N7O4S2/c1-11-5-6-12-3-2-4-15(18(12)23-11)14-7-8-16(32(28,29)13-9-22-10-13)19(33(21,30)31)17(14)20-24-26-27-25-20/h2-8,13,22H,9-10H2,1H3,(H2,21,30,31)(H,24,25,26,27) GEWAUZVCOZHFPS-UHFFFAOYSA-N 367935 3-((4-(2-methylquinolin- 8-yl)-2-sulfamoyl-3-(1H- tetrazol-5- yl)phenyl)sulfonyl)azetidin- 1-ium 2,2,2- trifluoroacetate::US10227331, Example 122 Metallo-beta-lactamase type 2 0.570 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367935 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367935&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135149795 402364795 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726730 Cn1ncc2c(cccc12)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)C1CNC1 InChI=1S/C18H18N8O4S2/c1-26-14-4-2-3-11(13(14)9-21-26)12-5-6-15(31(27,28)10-7-20-8-10)17(32(19,29)30)16(12)18-22-24-25-23-18/h2-6,9-10,20H,7-8H2,1H3,(H2,19,29,30)(H,22,23,24,25) BMENUIHVCNVONI-UHFFFAOYSA-N 367936 3-((4-(1-methyl-1H- indazol-4-yl)-2- sulfamoyl-3-(1H- tetrazol-5- yl)phenyl)sulfonyl)azetidin- 1-ium 2,2,2- trifluoroacetate::US10227331, Example 123 Metallo-beta-lactamase type 2 1.14 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367936 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367936&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135149883 402364796 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726733 NS(=O)(=O)c1c(ccc(-c2csc(n2)N2CCOCC2)c1-c1nnn[nH]1)S(=O)(=O)C1CNC1 InChI=1S/C17H20N8O5S3/c18-33(28,29)15-13(32(26,27)10-7-19-8-10)2-1-11(14(15)16-21-23-24-22-16)12-9-31-17(20-12)25-3-5-30-6-4-25/h1-2,9-10,19H,3-8H2,(H2,18,28,29)(H,21,22,23,24) WBJQMFXQBUUBPZ-UHFFFAOYSA-N 367937 3-((4-(2- morpholinothiazol-4-yl)- 2-sulfamoyl-3-(1H- tetrazol-5- yl)phenyl)sulfonyl)azetidin- 1-ium 2,2,2- trifluoroacetate::US10227331, Example 124 Metallo-beta-lactamase type 2 6.10 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367937 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367937&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135150017 402364797 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726736 NS(=O)(=O)c1c(ccc(-c2cccc(c2)C2CCC(=O)N2)c1-c1nnn[nH]1)S(=O)(=O)C1CNC1 367938 3-((3'-(5-oxopyrrolidin- 2-yl)-3-sulfamoyl-2-(1H- tetrazol-5-yl)-[1,1'- biphenyl]-4- yl)sulfonyl)azetidin-1- ium 2,2,2-trifluoroacetate::US10227331, Example 125 Metallo-beta-lactamase type 2 5.23 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367938 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367938&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135149851 402364798 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726940 Cc1ccc(-c2ccc(c(c2-c2nn[nH]n2)S(N)(=O)=O)S(C)(=O)=O)c2nc(N)sc12 InChI=1S/C16H15N7O4S3/c1-7-3-4-9(12-13(7)28-16(17)19-12)8-5-6-10(29(2,24)25)14(30(18,26)27)11(8)15-20-22-23-21-15/h3-6H,1-2H3,(H2,17,19)(H2,18,26,27)(H,20,21,22,23) IPCZATWTVPDENZ-UHFFFAOYSA-N 368006 3-(2-amino-7- methylbenzo[d]thiazol-4-yl)-6- (methylsulfonyl)-2-(2H- tetrazol-5- yl)benzenesulfonamide::US10227331, Example 193 Metallo-beta-lactamase type 2 0.094 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368006 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368006&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135150051 402364865 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726943 NCCCS(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C17H18N8O4S3/c18-7-2-8-31(26,27)12-6-5-9(10-3-1-4-11-14(10)21-17(19)30-11)13(15(12)32(20,28)29)16-22-24-25-23-16/h1,3-6H,2,7-8,18H2,(H2,19,21)(H2,20,28,29)(H,22,23,24,25) DTXZBEBFLONDNG-UHFFFAOYSA-N 368007 3-(2-aminobenzo[d]thiazol-4-yl)-6-(3-aminopropylsulfonyl)-2-(2H-tetrazol-5-yl)benzenesulfonamide::US10227331, Example 194 Metallo-beta-lactamase type 2 0.154 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368007 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368007&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135149899 402364866 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726946 Cn1c(N)nc2c(cccc12)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)CCCN InChI=1S/C18H21N9O4S2/c1-27-12-5-2-4-11(15(12)22-18(27)20)10-6-7-13(32(28,29)9-3-8-19)16(33(21,30)31)14(10)17-23-25-26-24-17/h2,4-7H,3,8-9,19H2,1H3,(H2,20,22)(H2,21,30,31)(H,23,24,25,26) XHZHIKFPBIEISA-UHFFFAOYSA-N 368008 3-(2-amino-1-methyl-1H- benzo[d]imidazol-4-yl)-6-(3- aminopropylsulfonyl)-2-(2H- tetrazol-5- yl)benzenesulfonamide::US10227331, Example 195 Metallo-beta-lactamase type 2 0.251 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368008 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368008&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135149954 402364867 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726949 Nc1c(cccc1-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)C1CNC1)C#N InChI=1S/C17H16N8O4S2/c18-6-9-2-1-3-12(15(9)19)11-4-5-13(30(26,27)10-7-21-8-10)16(31(20,28)29)14(11)17-22-24-25-23-17/h1-5,10,21H,7-8,19H2,(H2,20,28,29)(H,22,23,24,25) SABAERCYMFYMHG-UHFFFAOYSA-N 368009 2′-Amino-4-(azetidin-3-ylsulfonyl)-3′-cyano-2-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-3-sulfonamide::US10227331, Example 196 Metallo-beta-lactamase type 2 1.54 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368009 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368009&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 145713686 402364868 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727009 Nc1nc2c(cccn2n1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)C1CNC1 InChI=1S/C16H16N10O4S2/c17-16-20-15-10(2-1-5-26(15)23-16)9-3-4-11(31(27,28)8-6-19-7-8)13(32(18,29)30)12(9)14-21-24-25-22-14/h1-5,8,19H,6-7H2,(H2,17,23)(H2,18,29,30)(H,21,22,24,25) JWJRSIJITTUWED-UHFFFAOYSA-N 368029 3-(2-amino-[,2,4]triazolo[1,5-a]pyridin-8-yl)-6-(azetidin-3-ylsulfonyl)-2-(2H-tetrazol-5-yl)benzenesulfonamide::US10227331, Example 216 Metallo-beta-lactamase type 2 1.66 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368029 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368029&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124157342 402364888 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727012 Nc1nc2cc(ccn2n1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)C1CNC1 InChI=1S/C16H16N10O4S2/c17-16-20-12-5-8(3-4-26(12)23-16)10-1-2-11(31(27,28)9-6-19-7-9)14(32(18,29)30)13(10)15-21-24-25-22-15/h1-5,9,19H,6-7H2,(H2,17,23)(H2,18,29,30)(H,21,22,24,25) XGNVTKRUBQBPEI-UHFFFAOYSA-N 368030 3-(2-amino- [1,2,4]triazolo[1,5- a]pyridin-7-yl)-6-(azetidin- 3-ylsulfonyl)-2-(2H- tetrazol-5-yl) benzenesulfonamide::US10227331, Example 217 Metallo-beta-lactamase type 2 3.81 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368030 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368030&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135150142 402364889 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727015 NS(=O)(=O)c1c(ccc(C2=CCS(=O)(=O)CC2)c1-c1nn[nH]n1)S(=O)(=O)C1CNC1 InChI=1S/C15H18N6O6S3/c16-30(26,27)14-12(29(24,25)10-7-17-8-10)2-1-11(13(14)15-18-20-21-19-15)9-3-5-28(22,23)6-4-9/h1-3,10,17H,4-8H2,(H2,16,26,27)(H,18,19,20,21) UESUMIXULWRMID-UHFFFAOYSA-N 368031 6-(azetidin-3-ylsulfonyl)-3- (1,1-dioxido-3,6-dihydro- 2H-thiopyran-4-yl)-2-(2H- tetrazol-5-yl) benzenesulfonamide::US10227331, Example 218 Metallo-beta-lactamase type 2 3.55 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368031 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368031&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135149782 402364890 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727018 Nc1ncccc1-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)C1CNC1 InChI=1S/C15H16N8O4S2/c16-14-10(2-1-5-19-14)9-3-4-11(28(24,25)8-6-18-7-8)13(29(17,26)27)12(9)15-20-22-23-21-15/h1-5,8,18H,6-7H2,(H2,16,19)(H2,17,26,27)(H,20,21,22,23) AXHAFWLRMQMEDF-UHFFFAOYSA-N 368032 3-(2-aminopyridin-3-yl)-6- (azetidin-3-ylsulfonyl)-2- (2H-tetrazol-5-yl) benzenesulfonamide::US10227331, Example 219 Metallo-beta-lactamase type 2 5.66 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368032 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368032&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 145713692 402364891 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727063 CSc1ccc(-c2ccc(cc2)C2CCNCC2)c(-c2nnn[nH]2)c1S(N)(=O)=O InChI=1S/C19H22N6O2S2/c1-28-16-7-6-15(17(18(16)29(20,26)27)19-22-24-25-23-19)14-4-2-12(3-5-14)13-8-10-21-11-9-13/h2-7,13,21H,8-11H2,1H3,(H2,20,26,27)(H,22,23,24,25) PGZFAKNNHNPHPT-UHFFFAOYSA-N 368047 4-(Methylthio)-4′-(piperidin-4-yl)-2-(1H-tetrazol-5-yl)-[1,1′-biphenyl]-3-sulfonamide::US10227331, Example 234 Metallo-beta-lactamase type 2 4.37 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368047 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368047&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 145713702 402364905 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727066 CS(=O)c1ccc(-c2ccc(cc2)C2CCNCC2)c(-c2nnn[nH]2)c1S(N)(=O)=O 368048 4-(methylsulfinyl)-4′-(piperidin-4-yl)-2-(1H-tetrazol-5-yl)-[1,1′-biphenyl]-3-sulfonamide::US10227331, Example 235 Metallo-beta-lactamase type 2 23.6 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368048 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368048&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 145713703 402364906 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727069 CS(=O)(=O)c1ccc(-c2ccc(cc2)C2CCNCC2)c(-c2nnn[nH]2)c1S(N)(=O)=O InChI=1S/C19H22N6O4S2/c1-30(26,27)16-7-6-15(17(18(16)31(20,28)29)19-22-24-25-23-19)14-4-2-12(3-5-14)13-8-10-21-11-9-13/h2-7,13,21H,8-11H2,1H3,(H2,20,28,29)(H,22,23,24,25) JGSUJJQLDOGKRS-UHFFFAOYSA-N 368049 4-(methylsulfonyl)-4′-(piperidin-4-yl)-2-(1H-tetrazol-5-yl)-[1,1′-biphenyl]-3-sulfonamide::US10227331, Example 236 Metallo-beta-lactamase type 2 0.103 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368049 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368049&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 145713704 402364907 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727228 CCCn1c(N)nc2c(cccc12)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)C1CNC1 InChI=1S/C20H23N9O4S2/c1-2-8-29-14-5-3-4-13(17(14)24-20(29)21)12-6-7-15(34(30,31)11-9-23-10-11)18(35(22,32)33)16(12)19-25-27-28-26-19/h3-7,11,23H,2,8-10H2,1H3,(H2,21,24)(H2,22,32,33)(H,25,26,27,28) SCLVSLQZMGQDJI-UHFFFAOYSA-N 368102 3-(2-amino-1-propyl-1H-benzo[d]imidazol-4-yl)-6-(azetidin-3-ylsulfonyl)-2-(2H-tetrazol-5-yl)benzenesulfonamide::US10227331, Example 289 Metallo-beta-lactamase type 2 0.299 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368102 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368102&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135149791 402364957 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727231 NS(=O)(=O)c1c(ccc(-c2cccc3nc([nH]c23)C(O)=O)c1-c1nn[nH]n1)S(=O)(=O)[C@H]1CCNC1 InChI=1S/C19H16N8O6S2/c20-35(32,33)16-13(34(30,31)9-6-7-21-8-9)5-4-10(14(16)17-24-26-27-25-17)11-2-1-3-12-15(11)23-18(22-12)19(28)29/h1-5,9,21H,6-8H2,(H,28,29)(H2,20,32,33)/b11-10+/t9-/m0/s1 LHSIVEXZDJWJTI-YHTNPHCKSA-N 368103 7-(4-((S)-pyrrolidin-3-ylsulfonyl)-3-sulfamoyl-2-(2H-tetrazol-5-yl)phenyl)-1H-benzo[d]imidazole-2-carboxylic Acid::US10227331, Example 290 Metallo-beta-lactamase type 2 2.96 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368103 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368103&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 145713715 402364958 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727234 Nc1nc2c(cccc2[nH]1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)[C@H]1CN[C@H](CO)C1 InChI=1S/C19H19N9O5S2/c20-19-23-13-3-1-2-12(16(13)24-19)11-4-5-14(34(30,31)10-6-9(8-29)22-7-10)17(35(21,32)33)15(11)18-25-27-28-26-18/h1-5,9-10,22,29H,6-8H2,(H2,20,23)(H2,21,32,33)/b12-11+/t9-,10+/m0/s1 MEYSQVVFLBWBTD-XXQWGACESA-N 368104 3-(2-amino-1H-benzo[d]imidazol-4-yl)-6-((3R,5S)-5-(hydroxymethyl)pyrrolidin-3-ylsulfonyl)-2-(2H-tetrazol-5-yl)benzenesulfonamide::US10227331, Example 291 Metallo-beta-lactamase type 2 0.959 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368104 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368104&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135150096 402364959 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727237 Nc1nc2c(cccc2s1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)[C@H]1CN[C@H](CO)C1 368105 3-(2-aminobenzo[d]thiazol-4-yl)-6-((3R,5S)-5-(hydroxymethyl)pyrrolidin-3-ylsulfonyl)-2-(2H-tetrazol-5-yl)benzenesulfonamide::US10227331, Example 292 Metallo-beta-lactamase type 2 0.270 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368105 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368105&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135149933 402364960 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726517 CN1CC(C1)S(=O)(=O)c1ccc(-c2cccc3[nH]c(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C18H19N9O4S2/c1-27-7-9(8-27)32(28,29)13-6-5-10(11-3-2-4-12-15(11)22-18(19)21-12)14(16(13)33(20,30)31)17-23-25-26-24-17/h2-6,9H,7-8H2,1H3,(H3,19,21,22)(H2,20,30,31)(H,23,24,25,26) YDNSVSQSQHRZIB-UHFFFAOYSA-N 367865 3-(2-amino-1H- benzo[d]imidazol-4-yl)-6-(1- methylazetidin-3-ylsulfonyl)-2- (2H-tetrazol-5- yl)benzenesulfonamide::US10227331, Example 52 Metallo-beta-lactamase type 2 1.33 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367865 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367865&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 145713673 402364725 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726520 Nc1nc2c(cccc2[nH]1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)C1CN(CCO)C1 InChI=1S/C19H21N9O5S2/c20-19-22-13-3-1-2-12(16(13)23-19)11-4-5-14(34(30,31)10-8-28(9-10)6-7-29)17(35(21,32)33)15(11)18-24-26-27-25-18/h1-5,10,29H,6-9H2,(H3,20,22,23)(H2,21,32,33)(H,24,25,26,27) ODDLYINYHGXGQT-UHFFFAOYSA-N 367866 3-(2-amino-1H- benzo[d]imidazol-4-yl)-6-(1-(2- hydroxyethyl)azetidin-3- ylsulfonyl)-2-(2H-tetrazol-5- yl)benzenesulfonamide::US10227331, Example 53 Metallo-beta-lactamase type 2 6.12 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367866 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367866&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 145713674 402364726 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726523 CC(=O)N1CC(C1)S(=O)(=O)c1ccc(-c2cccc3nc(N)[nH]c23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C19H19N9O5S2/c1-9(29)28-7-10(8-28)34(30,31)14-6-5-11(12-3-2-4-13-16(12)23-19(20)22-13)15(17(14)35(21,32)33)18-24-26-27-25-18/h2-6,10H,7-8H2,1H3,(H3,20,22,23)(H2,21,32,33)(H,24,25,26,27) SXTDDUKKQSLXMI-UHFFFAOYSA-N 367867 6-(1-acetylazetidin-3- ylsulfonyl)-3-(2-amino-3H- benzo[d]imidazol-4-yl)-2-(2H- tetrazol-5- yl)benzenesulfonamide::US10227331, Example 54 Metallo-beta-lactamase type 2 2.38 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367867 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367867&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 145713675 402364727 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726526 CS(=O)(=O)N1CC(C1)S(=O)(=O)c1ccc(-c2cccc3[nH]c(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C18H19N9O6S3/c1-34(28,29)27-7-9(8-27)35(30,31)13-6-5-10(11-3-2-4-12-15(11)22-18(19)21-12)14(16(13)36(20,32)33)17-23-25-26-24-17/h2-6,9H,7-8H2,1H3,(H3,19,21,22)(H2,20,32,33)(H,23,24,25,26) UAXLUXVRUZYHBS-UHFFFAOYSA-N 367868 3-(2-amino-1H- benzo[d]imidazol-4-yl)-6-(1- (methylsulfonyl)azetidin-3- ylsulfonyl)-2-(2H-tetrazol-5- yl)benzenesulfonamide::US10227331, Example 55 Metallo-beta-lactamase type 2 1.42 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367868 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367868&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 145713676 402364728 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726529 NC(=O)N1CC(C1)S(=O)(=O)c1ccc(-c2cccc3[nH]c(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C18H18N10O5S2/c19-17-22-11-3-1-2-10(14(11)23-17)9-4-5-12(34(30,31)8-6-28(7-8)18(20)29)15(35(21,32)33)13(9)16-24-26-27-25-16/h1-5,8H,6-7H2,(H2,20,29)(H3,19,22,23)(H2,21,32,33)(H,24,25,26,27) CFSMLOYWJHXBMQ-UHFFFAOYSA-N 367869 3-(4-(2-amino-1H- benzo[d]imidazol-4-yl)-2- sulfamoyl-3-(2H-tetrazol-5- yl)phenylsulfonyl)azetidine-1- carboxamide::US10227331, Example 56 Metallo-beta-lactamase type 2 2.82 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367869 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367869&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 145713677 402364729 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726739 Cc1n[nH]c2ccc(cc12)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)C1CNC1 InChI=1S/C18H18N8O4S2/c1-9-13-6-10(2-4-14(13)22-21-9)12-3-5-15(31(27,28)11-7-20-8-11)17(32(19,29)30)16(12)18-23-25-26-24-18/h2-6,11,20H,7-8H2,1H3,(H,21,22)(H2,19,29,30)(H,23,24,25,26) HEPKXFPEBKABDX-UHFFFAOYSA-N 367939 3-((4-(3-methyl-1H- indazol-5-yl)-2- sulfamoyl-3-(1H- tetrazol-5- yl)phenyl)sulfonyl)azetidin- 1-ium 2,2,2- trifluoroacetate::US10227331, Example 126 Metallo-beta-lactamase type 2 0.715 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367939 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367939&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135149504 402364799 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726742 NS(=O)(=O)c1c(ccc(-c2ccc3cn[nH]c3c2)c1-c1nnn[nH]1)S(=O)(=O)C1CNC1 InChI=1S/C17H16N8O4S2/c18-31(28,29)16-14(30(26,27)11-7-19-8-11)4-3-12(15(16)17-22-24-25-23-17)9-1-2-10-6-20-21-13(10)5-9/h1-6,11,19H,7-8H2,(H,20,21)(H2,18,28,29)(H,22,23,24,25) UNCDVHFTJRRNBV-UHFFFAOYSA-N 367940 3-((4-(1H-indazol-6-yl)- 2-sulfamoyl-3-(1H- tetrazol-5- yl)phenyl)sulfonyl)azetidin- 1-ium 2,2,2- trifluoroacetate::US10227331, Example 127 Metallo-beta-lactamase type 2 3.01 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367940 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367940&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135149760 402364800 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726745 NS(=O)(=O)c1c(ccc(-c2cccc3cccnc23)c1-c1nnn[nH]1)S(=O)(=O)C1CNC1 InChI=1S/C19H17N7O4S2/c20-32(29,30)18-15(31(27,28)12-9-21-10-12)7-6-13(16(18)19-23-25-26-24-19)14-5-1-3-11-4-2-8-22-17(11)14/h1-8,12,21H,9-10H2,(H2,20,29,30)(H,23,24,25,26) CDLJJOOLWXGVAP-UHFFFAOYSA-N 367941 3-((4-(quinolin-8-yl)-2- sulfamoyl-3-(1H- tetrazol-5- yl)phenyl)sulfonyl)azetidin- 1-ium 2,2,2- trifluoroacetate::US10227331, Example 128 Metallo-beta-lactamase type 2 0.524 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367941 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367941&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135150190 402364801 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726748 NS(=O)(=O)c1c(ccc(-c2cnn3CCCCc23)c1-c1nnn[nH]1)S(=O)(=O)C1CNC1 InChI=1S/C17H20N8O4S2/c18-31(28,29)16-14(30(26,27)10-7-19-8-10)5-4-11(15(16)17-21-23-24-22-17)12-9-20-25-6-2-1-3-13(12)25/h4-5,9-10,19H,1-3,6-8H2,(H2,18,28,29)(H,21,22,23,24) RDPMUAAJHWCOEM-UHFFFAOYSA-N 367942 3-((2-sulfamoyl-4- (4,5,6,7- tetrahydropyrazolo[1,5- a]pyridin-3-yl)-3-(1H- tetrazol-5- yl)phenyl)sulfonyl)azetidin- 1-ium 2,2,2- trifluoroacetate::US10227331, Example 129 Metallo-beta-lactamase type 2 2.63 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367942 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367942&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 145713682 402364802 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726952 COC(=O)c1cccc(c1N)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)CCN InChI=1S/C17H19N7O6S2/c1-30-17(25)11-4-2-3-10(14(11)19)9-5-6-12(31(26,27)8-7-18)15(32(20,28)29)13(9)16-21-23-24-22-16/h2-6H,7-8,18-19H2,1H3,(H2,20,28,29)(H,21,22,23,24) WJWXTLCLFVZWPA-UHFFFAOYSA-N 368010 US10227331, Example 197::methyl 2-amino-4'-((2- aminoethyl)sulfonyl)- 3'-sulfamoyl-2'-(2H- tetrazol-5-yl)-[1,1'- biphenyl]-3- carboxylate Metallo-beta-lactamase type 2 0.554 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368010 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368010&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135149699 402364869 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726955 NCCS(=O)(=O)c1ccc(-c2cccc3[nH]cnc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C16H16N8O4S2/c17-6-7-29(25,26)12-5-4-9(10-2-1-3-11-14(10)20-8-19-11)13(15(12)30(18,27)28)16-21-23-24-22-16/h1-5,8H,6-7,17H2,(H,19,20)(H2,18,27,28)(H,21,22,23,24) OSDKUBWZWJSDCS-UHFFFAOYSA-N 368011 6-((2-aminoethyl) sulfonyl)-3-(1H- benzo[d]imidazol-4- yl)-2-(2H-tetrazol-5- yl)benzenesulfonamide::US10227331, Example 198 Metallo-beta-lactamase type 2 0.374 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368011 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368011&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 145713687 402364870 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726958 NCCS(=O)(=O)c1ccc(-c2cccc(C(O)=O)c2N)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C16H17N7O6S2/c17-6-7-30(26,27)11-5-4-8(9-2-1-3-10(13(9)18)16(24)25)12(14(11)31(19,28)29)15-20-22-23-21-15/h1-5H,6-7,17-18H2,(H,24,25)(H2,19,28,29)(H,20,21,22,23) KZRVSOYTAVEDLE-UHFFFAOYSA-N 368012 2-Amino-4′-((2-aminoethyl)sulfonyl)-3′-sulfamoyl-2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-3-carboxylic Acid::US10227331, Example 199 Metallo-beta-lactamase type 2 1.84 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368012 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368012&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135149656 402364871 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726961 NS(=O)(=O)c1c(ccc(-c2ccnc3[nH]nnc23)c1-c1nn[nH]n1)S(=O)(=O)C1CNC1 InChI=1S/C15H14N10O4S2/c16-31(28,29)13-10(30(26,27)7-5-17-6-7)2-1-8(11(13)14-20-24-25-21-14)9-3-4-18-15-12(9)19-23-22-15/h1-4,7,17H,5-6H2,(H2,16,28,29)(H,18,19,22,23)(H,20,21,24,25) NNLDWWHCLADXJV-UHFFFAOYSA-N 368013 3-(3H-[1,2,3]triazolo[4,5-b]pyridin-7-yl)-6-(azetidin-3-ylsulfonyl)-2-(2H-tetrazol-5-yl)benzenesulfonamide::US10227331, Example 200 Metallo-beta-lactamase type 2 13.7 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368013 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368013&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 145713688 402364872 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727021 NS(=O)(=O)c1c(ccc(-c2cccnc2N2CCOCC2)c1-c1nn[nH]n1)S(=O)(=O)C1CNC1 InChI=1S/C19H22N8O5S2/c20-34(30,31)17-15(33(28,29)12-10-21-11-12)4-3-13(16(17)18-23-25-26-24-18)14-2-1-5-22-19(14)27-6-8-32-9-7-27/h1-5,12,21H,6-11H2,(H2,20,30,31)(H,23,24,25,26) HTZZJPSTCGWLNN-UHFFFAOYSA-N 368033 6-(azetidin-3-ylsulfonyl)-3- (2-morpholinopyridin-3-yl)- 2-(2H-tetrazol-5-yl) benzenesulfonamide::US10227331, Example 220 Metallo-beta-lactamase type 2 14.9 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368033 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368033&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 145713693 402364892 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727024 NC(=N)Nc1ccccc1-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)C1CNC1 InChI=1S/C17H19N9O4S2/c18-17(19)22-12-4-2-1-3-10(12)11-5-6-13(31(27,28)9-7-21-8-9)15(32(20,29)30)14(11)16-23-25-26-24-16/h1-6,9,21H,7-8H2,(H4,18,19,22)(H2,20,29,30)(H,23,24,25,26) GWHLYYZPDPZRIU-UHFFFAOYSA-N 368034 4-(azetidin-3-ylsulfonyl)-2'- guanidino-2-(2H-tetrazol-5- yl)-[1,1'-biphenyl]-3- sulfonamide::US10227331, Example 221 Metallo-beta-lactamase type 2 44.0 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368034 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368034&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 145713694 402364893 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727027 NS(=O)(=O)c1c(ccc(C2CCOCC2)c1-c1nn[nH]n1)S(=O)(=O)C1CNC1 InChI=1S/C15H20N6O5S2/c16-28(24,25)14-12(27(22,23)10-7-17-8-10)2-1-11(9-3-5-26-6-4-9)13(14)15-18-20-21-19-15/h1-2,9-10,17H,3-8H2,(H2,16,24,25)(H,18,19,20,21) VILXEAVVUIJSAJ-UHFFFAOYSA-N 368035 6-(azetidin-3-ylsulfonyl)-3-(tetrahydro-2H-pyran-4-yl)-2-(2H-tetrazol-5-yl)benzenesulfonamide::US10227331, Example 222 Metallo-beta-lactamase type 2 4.30 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368035 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368035&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135149752 402364894 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727072 CS(=O)(=O)c1ccc(-c2ccc(N)nc2)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C13H13N7O4S2/c1-25(21,22)9-4-3-8(7-2-5-10(14)16-6-7)11(12(9)26(15,23)24)13-17-19-20-18-13/h2-6H,1H3,(H2,14,16)(H2,15,23,24)(H,17,18,19,20) CTQXTGOOHTUPCQ-UHFFFAOYSA-N 368050 3-(6-Aminopyridin-3-yl)-6-(methylsulfonyl)-2-(2H-tetrazol-5-yl)benzenesulfonamide::US10227331, Example 237 Metallo-beta-lactamase type 2 0.630 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368050 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368050&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124157172 402364908 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727075 CS(=O)(=O)c1ccc(-c2cnc3ccccn23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C15H13N7O4S2/c1-27(23,24)11-6-5-9(10-8-17-12-4-2-3-7-22(10)12)13(14(11)28(16,25)26)15-18-20-21-19-15/h2-8H,1H3,(H2,16,25,26)(H,18,19,20,21) PCYQLRMSIWXKPZ-UHFFFAOYSA-N 368051 3-(Imidazo[1,2-a]pyridin-3- yl)-6-(methylsulfonyl)-2- (2H-tetrazol-5-yl) benzenesulfonamide::US10227331, Example 238 Metallo-beta-lactamase type 2 0.333 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368051 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368051&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135150020 402364909 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727078 CS(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C15H13N7O4S3/c1-28(23,24)10-6-5-7(8-3-2-4-9-12(8)18-15(16)27-9)11(13(10)29(17,25)26)14-19-21-22-20-14/h2-6H,1H3,(H2,16,18)(H2,17,25,26)(H,19,20,21,22) AWYPPQZRCHLYES-UHFFFAOYSA-N 368052 3-(2-aminobenzo[d]thiazol- 4-yl)-6-(methylsulfonyl)-2- (2H-tetrazol-5-yl) benzenesulfonamide::US10227331, Example 239 Metallo-beta-lactamase type 2 0.091 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368052 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368052&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 145713705 402364910 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727081 CS(=O)(=O)c1ccc(-c2cccc3nc(N)[nH]c23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C15H14N8O4S2/c1-28(24,25)10-6-5-7(8-3-2-4-9-12(8)19-15(16)18-9)11(13(10)29(17,26)27)14-20-22-23-21-14/h2-6H,1H3,(H3,16,18,19)(H2,17,26,27)(H,20,21,22,23) MRJJCLXZMIDZOD-UHFFFAOYSA-N 368053 3-(2-Amino-1H- benzo[d]imidazol-7-yl)-6- (methylsulfonyl)-2- (2H-tetrazol-5-yl) benzenesulfonamide::US10227331, Example 240 Metallo-beta-lactamase type 2 7.46 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368053 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368053&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 145713706 402364911 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726532 CCOC(=O)N1CC(C1)S(=O)(=O)c1ccc(-c2cccc3[nH]c(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C20H21N9O6S2/c1-2-35-20(30)29-8-10(9-29)36(31,32)14-7-6-11(12-4-3-5-13-16(12)24-19(21)23-13)15(17(14)37(22,33)34)18-25-27-28-26-18/h3-7,10H,2,8-9H2,1H3,(H3,21,23,24)(H2,22,33,34)(H,25,26,27,28) IUMYNBVENHWFJF-UHFFFAOYSA-N 367870 US10227331, Example 57::ethyl 3-(4-(2-amino-1H- benzo[d]imidazol-4-yl)-2- sulfamoyl-3-(2H-tetrazol-5- yl)phenylsulfonyl)azetidine-1- carboxylate Metallo-beta-lactamase type 2 1.98 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367870 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367870&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 145713678 402364730 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726535 NS(=O)(=O)c1c(ccc(-c2cccn3ccnc23)c1-c1nnn[nH]1)S(=O)(=O)C1CNC1 InChI=1S/C17H16N8O4S2/c18-31(28,29)15-13(30(26,27)10-8-19-9-10)4-3-11(14(15)16-21-23-24-22-16)12-2-1-6-25-7-5-20-17(12)25/h1-7,10,19H,8-9H2,(H2,18,28,29)(H,21,22,23,24) XHYVUNYVGDBXGZ-UHFFFAOYSA-N 367871 6-(Azetidin-3-yl sulfonyl)-3-(imidazo[1,2-a]pyridin-8-yl)-2-(1H-tetrazol-5-yl)benzenesulfonamide::US10227331, Example 58 Metallo-beta-lactamase type 2 0.597 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367871 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367871&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124157319 402364731 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726538 NC(=O)c1cn2cccc(-c3ccc(c(c3-c3nnn[nH]3)S(N)(=O)=O)S(=O)(=O)C3CNC3)c2n1 InChI=1S/C18H17N9O5S2/c19-16(28)12-8-27-5-1-2-11(18(27)22-12)10-3-4-13(33(29,30)9-6-21-7-9)15(34(20,31)32)14(10)17-23-25-26-24-17/h1-5,8-9,21H,6-7H2,(H2,19,28)(H2,20,31,32)(H,23,24,25,26) BFCDFLCBRPFVRW-UHFFFAOYSA-N 367872 8-(4-(azetidin-3-ylsulfonyl)- 3-sulfamoyl-2-(1H-tetrazol- 5-yl)phenyl)imidazo[1,2- a]pyridine-2-carboxamide::US10227331, Example 59 Metallo-beta-lactamase type 2 1.44 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367872 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367872&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135150057 402364732 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726541 NS(=O)(=O)c1c(ccc(-c2cccn3cncc23)c1-c1nnn[nH]1)S(=O)(=O)C1CNC1 InChI=1S/C17H16N8O4S2/c18-31(28,29)16-14(30(26,27)10-6-19-7-10)4-3-12(15(16)17-21-23-24-22-17)11-2-1-5-25-9-20-8-13(11)25/h1-5,8-10,19H,6-7H2,(H2,18,28,29)(H,21,22,23,24) VLKOPIVWYDPSQO-UHFFFAOYSA-N 367873 6-(azetidin-3-ylsulfonyl)-3- (imidazo[1,5-a]pyridin-8-yl)- 2-(1H-tetrazol-5- yl)benzenesulfonamide::US10227331, Example 60 Metallo-beta-lactamase type 2 2.35 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367873 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367873&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135149981 402364733 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726964 NS(=O)(=O)c1c(ccc(-c2cccc3scnc23)c1-c1nn[nH]n1)S(=O)(=O)C1CNC1 InChI=1S/C17H15N7O4S3/c18-31(27,28)16-13(30(25,26)9-6-19-7-9)5-4-10(14(16)17-21-23-24-22-17)11-2-1-3-12-15(11)20-8-29-12/h1-5,8-9,19H,6-7H2,(H2,18,27,28)(H,21,22,23,24) VEBDVARMABIYMN-UHFFFAOYSA-N 368014 6-(Azetidin-3-ylsulfonyl)-3-(benzo[d]thiazol-4-yl)-2-(2H-tetrazol-5-yl)benzenesulfonamide::US10227331, Example 201 Metallo-beta-lactamase type 2 0.153 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368014 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368014&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135150120 402364873 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726967 NCCS(=O)(=O)c1ccc(-c2cccc3n(C4CNC4)c(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C19H22N10O4S2/c20-6-7-34(30,31)14-5-4-11(15(17(14)35(22,32)33)18-25-27-28-26-18)12-2-1-3-13-16(12)24-19(21)29(13)10-8-23-9-10/h1-5,10,23H,6-9,20H2,(H2,21,24)(H2,22,32,33)(H,25,26,27,28) RCTXEPBCWZVWLM-UHFFFAOYSA-N 368015 3-(2-amino-1-(azetidin-3-yl)-1H-benzo[d]imidazol-4-yl)-6-((2-aminoethyl)sulfonyl)-2-(2H-tetrazol-5-yl)benzenesulfonamide::US10227331, Example 202 Metallo-beta-lactamase type 2 0.859 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368015 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368015&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 145713689 402364874 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726970 NC1CCC(CC1)c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)CC1CNC1 InChI=1S/C17H25N7O4S2/c18-12-3-1-11(2-4-12)13-5-6-14(29(25,26)9-10-7-20-8-10)16(30(19,27)28)15(13)17-21-23-24-22-17/h5-6,10-12,20H,1-4,7-9,18H2,(H2,19,27,28)(H,21,22,23,24) GJMJAJCQBHZEAJ-UHFFFAOYSA-N 368016 3-(4-aminocyclohexyl)-6-((azetidin-3-ylmethyl)sulfonyl)-2-(1H-tetrazol-5-yl)benzenesulfonamide::US10227331, Example 203 Metallo-beta-lactamase type 2 22.9 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368016 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368016&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124157252 402364875 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727084 CS(=O)(=O)c1ccc(-c2ccc(NS(=O)(=O)C3CC3)cc2)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C17H18N6O6S3/c1-30(24,25)14-9-8-13(15(16(14)31(18,26)27)17-19-22-23-20-17)10-2-4-11(5-3-10)21-32(28,29)12-6-7-12/h2-5,8-9,12,21H,6-7H2,1H3,(H2,18,26,27)(H,19,20,22,23) XYNDJWFFJQQRMO-UHFFFAOYSA-N 368054 4'- (Cyclopropanesulfonamido)- 4-(methylsulfonyl)-2-(2H- tetrazol-5-yl)-[1,1'- biphenyl]-3-sulfonamide::US10227331, Example 241 Metallo-beta-lactamase type 2 0.044 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368054 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368054&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 145713707 402364912 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727087 NS(=O)(=O)c1c(Sc2ccncc2)ccc(-c2ccc(cc2)C2CCNCC2)c1-c1nn[nH]n1 InChI=1S/C23H23N7O2S2/c24-34(31,32)22-20(33-18-9-13-26-14-10-18)6-5-19(21(22)23-27-29-30-28-23)17-3-1-15(2-4-17)16-7-11-25-12-8-16/h1-6,9-10,13-14,16,25H,7-8,11-12H2,(H2,24,31,32)(H,27,28,29,30) SYMHWZPMOURGHP-UHFFFAOYSA-N 368055 4′-(Piperidin-4-yl)-4-(pyridin-4-ylthio)-2-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-3-sulfonamide::US10227331, Example 242 Metallo-beta-lactamase type 2 3.34 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368055 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368055&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 145713708 402364913 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727090 NS(=O)(=O)c1c(SC2CNC2)ccc(-c2ccc(NS(=O)(=O)C3CC3)cc2)c1-c1nn[nH]n1 InChI=1S/C19H21N7O4S3/c20-32(27,28)18-16(31-13-9-21-10-13)8-7-15(17(18)19-22-25-26-23-19)11-1-3-12(4-2-11)24-33(29,30)14-5-6-14/h1-4,7-8,13-14,21,24H,5-6,9-10H2,(H2,20,27,28)(H,22,23,25,26) KICQJYWIWRZQMO-UHFFFAOYSA-N 368056 4-(Azetidin-3-ylthio)-4′-(cyclopropanesulfonamido)-2-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-3-sulfonamide::US10227331, Example 243 Metallo-beta-lactamase type 2 11.3 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368056 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368056&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124159610 402364914 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727093 NS(=O)(=O)c1c(ccc(-c2ccc(NS(=O)(=O)C3CC3)cc2)c1-c1nn[nH]n1)S(=O)(=O)C1CNC1 InChI=1S/C19H21N7O6S3/c20-34(29,30)18-16(33(27,28)14-9-21-10-14)8-7-15(17(18)19-22-25-26-23-19)11-1-3-12(4-2-11)24-35(31,32)13-5-6-13/h1-4,7-8,13-14,21,24H,5-6,9-10H2,(H2,20,29,30)(H,22,23,25,26) CWNUBBYODSZTFB-UHFFFAOYSA-N 368057 4-(Azetidin-3-ylsulfonyl)-4′-(cyclopropanesulfonamido)-2-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-3-sulfonamide::US10227331, Example 244 Metallo-beta-lactamase type 2 0.144 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368057 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368057&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124159599 402364915 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727240 NC[C@H](N)CS(=O)(=O)c1ccc(-c2cccc3[nH]c(N)nc23)c(-c2nnn[nH]2)c1S(N)(=O)=O InChI=1S/C17H18N10O4S2/c18-6-8(19)7-32(28,29)12-5-4-9(10-2-1-3-11-14(10)23-17(20)22-11)13(15(12)33(21,30)31)16-24-26-27-25-16/h1-5,8H,6-7,18-19H2,(H2,20,22)(H2,21,30,31)/b10-9+/t8-/m0/s1 WMFMOMKBVKPAGQ-VPOJCXOPSA-N 368106 3-(2-amino-1H-benzo[d]imidazol-4-yl)-6-((S)-2,3-diaminopropylsulfonyl)-2-(1H-tetrazol-5-yl)benzenesulfonamide::US10227331, Example 293 Metallo-beta-lactamase type 2 1.31 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368106 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368106&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 145713716 402364961 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727243 C[C@H](N)CS(=O)(=O)c1ccc(-c2cccc3[nH]c(nc23)C(O)=O)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C18H16N8O6S2/c1-8(19)7-33(29,30)12-6-5-9(13(15(12)34(20,31)32)16-23-25-26-24-16)10-3-2-4-11-14(10)22-17(21-11)18(27)28/h2-6,8H,7,19H2,1H3,(H,27,28)(H2,20,31,32)/b10-9+/t8-/m0/s1 VEDGMINPDLTVAB-VPOJCXOPSA-N 368107 4-(4-((S)-2-aminopropylsulfonyl)-3-sulfamoyl-2-(2H-tetrazol-5-yl)phenyl)-1H-benzo[d]imidazole-2-carboxylic Acid::US10227331, Example 294 Metallo-beta-lactamase type 2 0.350 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368107 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368107&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 145713717 402364962 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727246 NCCS(=O)(=O)c1ccc(-c2ccc(C#N)c3nc(N)[nH]c23)c(-c2nnn[nH]2)c1S(N)(=O)=O InChI=1S/C17H16N10O4S2/c18-5-6-32(28,29)11-4-3-9(12(15(11)33(21,30)31)16-24-26-27-25-16)10-2-1-8(7-19)13-14(10)23-17(20)22-13/h1-4H,5-6,18H2,(H3,20,22,23)(H2,21,30,31)(H,24,25,26,27) AXNVDSSAHQBMDO-UHFFFAOYSA-N 368108 3-(2-amino-4-cyano-1H-benzo[d]imidazol-7-yl)-6-((2-aminoethyl)sulfonyl)-2-(1H-tetrazol-5-yl)benzenesulfonamide::US10227331, Example 295 Metallo-beta-lactamase type 2 1.22 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368108 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368108&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135149545 402364963 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727249 Nc1nc2cc(F)cc(-c3ccc(c(c3-c3nnn[nH]3)S(N)(=O)=O)S(=O)(=O)C3CNC3)c2[nH]1 InChI=1S/C17H16FN9O4S2/c18-7-3-10(14-11(4-7)22-17(19)23-14)9-1-2-12(32(28,29)8-5-21-6-8)15(33(20,30)31)13(9)16-24-26-27-25-16/h1-4,8,21H,5-6H2,(H3,19,22,23)(H2,20,30,31)(H,24,25,26,27) DXOQIYNMGZMNIU-UHFFFAOYSA-N 368075 3-(2-amino-5-fluoro-1H- benzo[d]imidazol-7-yl)-6- (azetidin-3-ylsulfonyl)-2- (1H-tetrazol-5-yl) benzenesulfonamide::US10227331, Example 262::US10227331, Example 296 Metallo-beta-lactamase type 2 0.297 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368075 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368075&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135149657 402364931 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726544 NS(=O)(=O)c1c(ccc(-c2cccn3cc(nc23)C(O)=O)c1-c1nnn[nH]1)S(=O)(=O)C1CNC1 InChI=1S/C18H16N8O6S2/c19-34(31,32)15-13(33(29,30)9-6-20-7-9)4-3-10(14(15)16-22-24-25-23-16)11-2-1-5-26-8-12(18(27)28)21-17(11)26/h1-5,8-9,20H,6-7H2,(H,27,28)(H2,19,31,32)(H,22,23,24,25) YUAUEVJJMYWWET-UHFFFAOYSA-N 367874 8-(4-(Azetidin-3-ylsulfonyl)-3-sulfamoyl-2-(1H-tetrazol-5-yl)phenyl)imidazo[1,2-a]pyridine-2-carboxylic Acid::US10227331, Example 61 Metallo-beta-lactamase type 2 2.22 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367874 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367874&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124157563 402364734 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726547 NC(=N)c1nc2c(cccc2s1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)C1CNC1 InChI=1S/C18H17N9O4S3/c19-16(20)18-23-14-10(2-1-3-11(14)32-18)9-4-5-12(33(28,29)8-6-22-7-8)15(34(21,30)31)13(9)17-24-26-27-25-17/h1-5,8,22H,6-7H2,(H3,19,20)(H2,21,30,31)(H,24,25,26,27) QZFIFKOZQPTGIV-UHFFFAOYSA-N 367875 4-(4-(Azetidin-3-ylsulfonyl)-3-sulfamoyl-2-(1H-tetrazol-5-yl)phenyl)benzo[d]thiazole-2-carboximidamide::US10227331, Example 62 Metallo-beta-lactamase type 2 2.63 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367875 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367875&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124157527 402364735 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726550 NS(=O)(=O)c1c(SC2CNC2)ccc(-c2cccc3nccn23)c1-c1nnn[nH]1 InChI=1S/C17H16N8O2S2/c18-29(26,27)16-13(28-10-8-19-9-10)5-4-11(15(16)17-21-23-24-22-17)12-2-1-3-14-20-6-7-25(12)14/h1-7,10,19H,8-9H2,(H2,18,26,27)(H,21,22,23,24) WYCCHHJBUHQZIS-UHFFFAOYSA-N 367876 6-(Azetidin-3-ylthio)-3-(imidazo[1,2-a]pyridin-5-yl)-2-(1H-tetrazol-5-yl)benzenesulfonamide::US10227331, Example 63 Metallo-beta-lactamase type 2 125 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367876 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367876&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124157552 402364736 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726553 NCCS(=O)(=O)c1ccc(-c2cccn3ccnc23)c(-c2nnn[nH]2)c1S(N)(=O)=O InChI=1S/C16H16N8O4S2/c17-5-9-29(25,26)12-4-3-10(11-2-1-7-24-8-6-19-16(11)24)13(14(12)30(18,27)28)15-20-22-23-21-15/h1-4,6-8H,5,9,17H2,(H2,18,27,28)(H,20,21,22,23) XYEPZCGUBJYOKE-UHFFFAOYSA-N 367877 6-((2-Aminoethyl)sulfonyl)-3-(imidazo[1,2-a]pyridin-8-yl)-2-(1H-tetrazol-5-yl)benzenesulfonamide::US10227331, Example 64 Metallo-beta-lactamase type 2 0.359 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367877 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367877&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124157490 402364737 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726556 Nc1cn2cccc(-c3ccc(c(c3-c3nnn[nH]3)S(N)(=O)=O)S(=O)(=O)C3CNC3)c2n1 InChI=1S/C17H17N9O4S2/c18-13-8-26-5-1-2-11(17(26)21-13)10-3-4-12(31(27,28)9-6-20-7-9)15(32(19,29)30)14(10)16-22-24-25-23-16/h1-5,8-9,20H,6-7,18H2,(H2,19,29,30)(H,22,23,24,25) AIKGUVJQVBZJKO-UHFFFAOYSA-N 367878 3-(2-Aminoimidazo[1,2-a]pyridin-8-yl)-6-(azetidin-3-ylsulfonyl)-2-(H-tetraazol-5-yl)benzenesulfonamide::US10227331, Example 65 Metallo-beta-lactamase type 2 2.50 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367878 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367878&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124157439 402364738 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726973 N[C@H]1CC[C@@H](CC1)c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)CC1CNC1 368017 3-((1r,4r)-4-aminocyclohexyl)-6-((azetidin-3-ylmethyl)sulfonyl)-2-(1H-tetrazol-5-yl)benzenesulfonamide::US10227331, Example 204 Metallo-beta-lactamase type 2 37.5 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368017 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368017&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124157252 402364876 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726976 N[C@H]1CC[C@H](CC1)c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)CC1CNC1 368018 3-((1s, 4s)-4-aminocyclohexyl)-6-((azetidin-3-ylmethyl)sulfonyl)-2-(1H-tetrazol-5-yl)benzenesulfonamide::US10227331, Example 205 Metallo-beta-lactamase type 2 82.5 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368018 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368018&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124157252 402364877 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726979 NC1CCC(CC1)c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)C1CCNCC1 InChI=1S/C18H27N7O4S2/c19-12-3-1-11(2-4-12)14-5-6-15(30(26,27)13-7-9-21-10-8-13)17(31(20,28)29)16(14)18-22-24-25-23-18/h5-6,11-13,21H,1-4,7-10,19H2,(H2,20,28,29)(H,22,23,24,25) YFMXVEDASAQRMM-UHFFFAOYSA-N 368019 3-(4-aminocyclohexyl)-6- (piperidin-4-ylsulfonyl)-2- (1H-tetrazol-5-yl) benzenesulfonamide::US10227331, Example 206 Metallo-beta-lactamase type 2 23.5 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368019 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368019&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135149633 402364878 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726982 N[C@H]1CC[C@@H](CC1)c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)C1CCNCC1 368020 3-((1r,4r)-4- aminocyclohexyl)-6- (piperidin-4-ylsulfonyl)-2- (1H-tetrazol-5-yl) benzenesulfonamide::US10227331, Example 207 Metallo-beta-lactamase type 2 24.6 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368020 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368020&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135149633 402364879 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727252 NS(=O)(=O)c1c(ccc(-c2cccc3cn[nH]c23)c1-c1nnn[nH]1)S(=O)(=O)C1CNC1 InChI=1S/C17H16N8O4S2/c18-31(28,29)16-13(30(26,27)10-7-19-8-10)5-4-11(14(16)17-22-24-25-23-17)12-3-1-2-9-6-20-21-15(9)12/h1-6,10,19H,7-8H2,(H,20,21)(H2,18,28,29)(H,22,23,24,25) BEXLDBCHKZVKQT-UHFFFAOYSA-N 368110 6-(azetidin-3-ylsulfonyl)-3-(1H-indazol-7-yl)-2-(1H-tetrazol-5-yl)benzenesulfonamide::US10227331, Example 297 Metallo-beta-lactamase type 2 0.596 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368110 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368110&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135149649 402364964 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727255 NCCS(=O)(=O)c1ccc(-c2cccc3cn[nH]c23)c(-c2nnn[nH]2)c1S(N)(=O)=O InChI=1S/C16H16N8O4S2/c17-6-7-29(25,26)12-5-4-10(11-3-1-2-9-8-19-20-14(9)11)13(15(12)30(18,27)28)16-21-23-24-22-16/h1-5,8H,6-7,17H2,(H,19,20)(H2,18,27,28)(H,21,22,23,24) SNHBVLHRDICBIW-UHFFFAOYSA-N 367986 2-((4-(1H-indazol-7-yl)- 2-sulfamoyl-3-(1H- tetrazol-5- yl)phenyl)sulfonyl) ethanaminium 2,2,2- trifluoroacetate::US10227331, Example 173::US10227331, Example 298 Metallo-beta-lactamase type 2 0.300 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367986 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367986&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135149710 402364846 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727258 NS(=O)(=O)c1c(ccc(-c2cccc3[nH]c(=O)[nH]c23)c1-c1nnn[nH]1)S(=O)(=O)C1CNC1 InChI=1S/C17H16N8O5S2/c18-32(29,30)15-12(31(27,28)8-6-19-7-8)5-4-9(13(15)16-22-24-25-23-16)10-2-1-3-11-14(10)21-17(26)20-11/h1-5,8,19H,6-7H2,(H2,18,29,30)(H2,20,21,26)(H,22,23,24,25) DYPCMWKQSAVFBW-UHFFFAOYSA-N 368112 6-(azetidin-3-ylsulfonyl)-3-(2- oxo-2,3-dihydro-1H- benzo[d]imidazol-4-yl)-2-(1H- tetrazol-5-yl) benzenesulfonamide::US10227331, Example 299 Metallo-beta-lactamase type 2 1.45 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368112 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368112&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 145713718 402364965 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727261 NCCS(=O)(=O)c1ccc(-c2cccc3[nH]c(=O)[nH]c23)c(-c2nnn[nH]2)c1S(N)(=O)=O InChI=1S/C16H16N8O5S2/c17-6-7-30(26,27)11-5-4-8(9-2-1-3-10-13(9)20-16(25)19-10)12(14(11)31(18,28)29)15-21-23-24-22-15/h1-5H,6-7,17H2,(H2,18,28,29)(H2,19,20,25)(H,21,22,23,24) IXCYFKTYYYHTOW-UHFFFAOYSA-N 367963 2-((4-(2-oxo-2,3- dihydro-1H- benzo[d]imidazol-4-yl)- 2-sulfamoyl-3-(1H- tetrazol-5- yl)phenyl)sulfonyl) ethanaminium 2,2,2- trifluoroacetate::US10227331, Example 150::US10227331, Example 300 Metallo-beta-lactamase type 2 0.415 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367963 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367963&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 145713684 402364823 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727264 NS(=O)(=O)c1c(ccc(-c2cncc3[nH]c(=O)[nH]c23)c1-c1nnn[nH]1)S(=O)(=O)C1CNC1 InChI=1S/C16H15N9O5S2/c17-32(29,30)14-11(31(27,28)7-3-18-4-7)2-1-8(12(14)15-22-24-25-23-15)9-5-19-6-10-13(9)21-16(26)20-10/h1-2,5-7,18H,3-4H2,(H2,17,29,30)(H2,20,21,26)(H,22,23,24,25) IVDJUWIIPQMZSC-UHFFFAOYSA-N 368114 6-(azetidin-3-ylsulfonyl)-3-(2-oxo-2,3-dihydro-1H-imidazo[4,5-c]pyridin-7-yl)-2-(1H-tetrazol-5-yl)benzenesulfonamide::US10227331, Example 301 Metallo-beta-lactamase type 2 2.87 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368114 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368114&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 145713719 402364966 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726559 NS(=O)(=O)c1c(ccc(-c2cccc3nccn23)c1-c1nnn[nH]1)S(=O)(=O)C1CNC1 InChI=1S/C17H16N8O4S2/c18-31(28,29)16-13(30(26,27)10-8-19-9-10)5-4-11(15(16)17-21-23-24-22-17)12-2-1-3-14-20-6-7-25(12)14/h1-7,10,19H,8-9H2,(H2,18,28,29)(H,21,22,23,24) MLYDAXVVMRBRMI-UHFFFAOYSA-N 367879 6-(Azetidin-3-ylsulfonyl)-3-(imidazo[1,2-a]pyridin-5-yl)-2-(1H-tetrazol-5-yl)benzenesulfonamide::US10227331, Example 66 Metallo-beta-lactamase type 2 9.67 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367879 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367879&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124157504 402364739 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726562 NC(=O)c1ccc(c(N)n1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)C1CNC1 InChI=1S/C16H17N9O5S2/c17-14-9(1-3-10(21-14)15(18)26)8-2-4-11(31(27,28)7-5-20-6-7)13(32(19,29)30)12(8)16-22-24-25-23-16/h1-4,7,20H,5-6H2,(H2,17,21)(H2,18,26)(H2,19,29,30)(H,22,23,24,25) JSHITWQUCAKMBV-UHFFFAOYSA-N 367880 6-Amino-5-(4-(azetidin-3-ylsulfonyl)-3-sulfamoyl-2-(1H-tetrazol-5-yl)phenyl)picolinamide::US10227331, Example 67 Metallo-beta-lactamase type 2 1.32 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367880&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124157273 402364740 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726565 NS(=O)(=O)c1c(ccc(-c2cccc3sc(nc23)C(O)=O)c1-c1nnn[nH]1)S(=O)(=O)C1CNC1 InChI=1S/C18H15N7O6S3/c19-34(30,31)15-12(33(28,29)8-6-20-7-8)5-4-9(13(15)16-22-24-25-23-16)10-2-1-3-11-14(10)21-17(32-11)18(26)27/h1-5,8,20H,6-7H2,(H,26,27)(H2,19,30,31)(H,22,23,24,25) ZPEPUUQUXSIBTH-UHFFFAOYSA-N 367881 4-(4-(azetidin-3-ylsulfonyl)-3-sulfamoyl-2-(1H-tetrazol-5-yl)phenyl)benzo[d]thiazole-2-carboxylic Acid::US10227331, Example 68 Metallo-beta-lactamase type 2 0.356 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367881 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367881&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124159651 402364741 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726568 NCCS(=O)(=O)c1ccc(-c2ccc3[nH]c(N)nc3c2)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C16H17N9O4S2/c17-5-6-30(26,27)12-4-2-9(8-1-3-10-11(7-8)21-16(18)20-10)13(14(12)31(19,28)29)15-22-24-25-23-15/h1-4,7H,5-6,17H2,(H3,18,20,21)(H2,19,28,29)(H,22,23,24,25) VNXOPFNEZSOYEL-UHFFFAOYSA-N 367882 3-(2-amino-1H-benzo[d]imidazol-5-yl)-6-(2-aminoethylsulfonyl)-2-(2H-tetrazol-5-yl)benzenesulfonamide::US10227331, Example 69 Metallo-beta-lactamase type 2 2.77 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367882 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367882&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124157317 402364742 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726571 NCCS(=O)(=O)c1ccc(-c2cccc3nc(N)[nH]c23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C16H17N9O4S2/c17-6-7-30(26,27)11-5-4-8(9-2-1-3-10-13(9)21-16(18)20-10)12(14(11)31(19,28)29)15-22-24-25-23-15/h1-5H,6-7,17H2,(H3,18,20,21)(H2,19,28,29)(H,22,23,24,25) ASAZVVSUHCMYAU-UHFFFAOYSA-N 367883 3-(2-amino-3H-benzo[d]imidazol- 4-yl)-6-(2-aminoethylsulfonyl)-2- (2H-tetrazol-5- yl)benzenesulfonamide::US10227331, Example 70 Metallo-beta-lactamase type 2 0.796 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367883 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367883&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 145713679 402364743 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727096 NS(=O)(=O)c1c(ccc(-c2ccc(NS(=O)(=O)C3CC3)cc2)c1-c1nn[nH]n1)S(=O)(=O)C1CN(C1)C(=O)NC1CC1 InChI=1S/C23H26N8O7S3/c24-40(35,36)21-19(39(33,34)17-11-31(12-17)23(32)25-14-5-6-14)10-9-18(20(21)22-26-29-30-27-22)13-1-3-15(4-2-13)28-41(37,38)16-7-8-16/h1-4,9-10,14,16-17,28H,5-8,11-12H2,(H,25,32)(H2,24,35,36)(H,26,27,29,30) JYJIYIXQSOMJKY-UHFFFAOYSA-N 368058 3-((4′-(Cyclopropanesulfonamido)-3-sulfamoyl-2-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)sulfonyl)-N-cyclopropylazetidine-1-carboxamide and 3-((4′-(cyclopropanesulfonamido)-3-sulfamoyl-2-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)sulfonyl)azetidine-1-carboxamide::US10227331, Example 245::US10227331, Example 246 Metallo-beta-lactamase type 2 0.126 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368058 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368058&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135149611 402364916 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727099 NS(=O)(=O)c1c(ccc(-c2ccc(NS(=O)(=O)C3CC3)cc2)c1-c1nn[nH]n1)S(=O)(=O)C1CN(C1)C(=O)NC1CC1 InChI=1S/C23H26N8O7S3/c24-40(35,36)21-19(39(33,34)17-11-31(12-17)23(32)25-14-5-6-14)10-9-18(20(21)22-26-29-30-27-22)13-1-3-15(4-2-13)28-41(37,38)16-7-8-16/h1-4,9-10,14,16-17,28H,5-8,11-12H2,(H,25,32)(H2,24,35,36)(H,26,27,29,30) JYJIYIXQSOMJKY-UHFFFAOYSA-N 368058 3-((4′-(Cyclopropanesulfonamido)-3-sulfamoyl-2-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)sulfonyl)-N-cyclopropylazetidine-1-carboxamide and 3-((4′-(cyclopropanesulfonamido)-3-sulfamoyl-2-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)sulfonyl)azetidine-1-carboxamide::US10227331, Example 245::US10227331, Example 246 Metallo-beta-lactamase type 2 0.103 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368058 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368058&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135149611 402364916 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727267 Nc1nc2nccc(-c3ccc(c(c3-c3nnn[nH]3)S(N)(=O)=O)S(=O)(=O)C3CNC3)c2[nH]1 InChI=1S/C16H16N10O4S2/c17-16-21-12-9(3-4-20-15(12)22-16)8-1-2-10(31(27,28)7-5-19-6-7)13(32(18,29)30)11(8)14-23-25-26-24-14/h1-4,7,19H,5-6H2,(H2,18,29,30)(H3,17,20,21,22)(H,23,24,25,26) ZCFFUMFVXRZZSK-UHFFFAOYSA-N 368115 3-(2-amino-1H-benzo[d]imidazol-7-yl)-6-(azetidin-3-ylsulfonyl)-2-(1H-tetrazol-5-yl)benzenesulfonamide::US10227331, Example 302 Metallo-beta-lactamase type 2 105 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368115 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368115&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135150229 402364967 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727270 NCCS(=O)(=O)c1ccc(-c2ccnc3nc(N)[nH]c23)c(-c2nnn[nH]2)c1S(N)(=O)=O InChI=1S/C15H16N10O4S2/c16-4-6-30(26,27)9-2-1-7(8-3-5-19-14-11(8)20-15(17)21-14)10(12(9)31(18,28)29)13-22-24-25-23-13/h1-3,5H,4,6,16H2,(H2,18,28,29)(H3,17,19,20,21)(H,22,23,24,25) MRAZCIIMPAKTLU-UHFFFAOYSA-N 368116 3-(2-amino-1H-imidazo[4,5-b]pyridin-7-yl)-6-((2-aminoethyl)sulfonyl)-2-(1H-tetrazol-5-yl)benzenesulfonamide::US10227331, Example 303 Metallo-beta-lactamase type 2 111 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368116 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368116&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135149988 402364968 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727273 NCCS(=O)(=O)c1ccc(-c2cccc3nc(nn23)C(O)=O)c(-c2nnn[nH]2)c1S(N)(=O)=O InChI=1S/C16H15N9O6S2/c17-6-7-32(28,29)10-5-4-8(12(13(10)33(18,30)31)14-20-23-24-21-14)9-2-1-3-11-19-15(16(26)27)22-25(9)11/h1-5H,6-7,17H2,(H,26,27)(H2,18,30,31)(H,20,21,23,24) ZCVJCKAFNGCCKW-UHFFFAOYSA-N 368117 5-(4-((2-aminoethyl)sulfonyl)-3-sulfamoyl-2-(1H-tetrazol-5-yl)phenyl)-[1,2,4]triazolo [1,5-a]pyridine-2-carb oxylic Acid::US10227331, Example 304 Metallo-beta-lactamase type 2 5.36 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368117 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368117&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124157407 402364969 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727276 NCCS(=O)(=O)c1ccc(-c2cccc3[nH]c(CN)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C17H19N9O4S2/c18-6-7-31(27,28)12-5-4-9(10-2-1-3-11-15(10)22-13(8-19)21-11)14(16(12)32(20,29)30)17-23-25-26-24-17/h1-5H,6-8,18-19H2,(H,21,22)(H2,20,29,30)(H,23,24,25,26) OLJRFBYBMVQADL-UHFFFAOYSA-N 368118 6-((2-aminoethyl)sulfonyl)-3-(2-(aminomethyl)-1H-benzo[d]imidazol-4-yl)-2-(2H-tetrazol-5-yl)benzenesulfonamide::US10227331, Example 305 Metallo-beta-lactamase type 2 1.91 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368118 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368118&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 145713720 402364970 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726574 NCCS(=O)(=O)c1ccc(-c2cccc3ccc(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C18H18N8O4S2/c19-8-9-31(27,28)13-6-5-11(12-3-1-2-10-4-7-14(20)22-16(10)12)15(17(13)32(21,29)30)18-23-25-26-24-18/h1-7H,8-9,19H2,(H2,20,22)(H2,21,29,30)(H,23,24,25,26) CUSQZHDBPLDWIO-UHFFFAOYSA-N 367884 6-(2-aminoethylsulfonyl)-3-(2- aminoquinolin-8-yl)-2-(2H- tetrazol-5-yl)benzenesulfonamide::US10227331, Example 71 Metallo-beta-lactamase type 2 0.129 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367884 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367884&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 145713680 402364744 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726577 NCCS(=O)(=O)c1ccc(-c2ccc(c3sc(N)nc23)C(F)(F)F)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C17H15F3N8O4S3/c18-17(19,20)9-3-1-8(12-13(9)33-16(22)24-12)7-2-4-10(34(29,30)6-5-21)14(35(23,31)32)11(7)15-25-27-28-26-15/h1-4H,5-6,21H2,(H2,22,24)(H2,23,31,32)(H,25,26,27,28) DETKZWOGFVMQBJ-UHFFFAOYSA-N 367885 3-(2-amino-7- (trifluoromethyl)benzo[d]thiazol- 4-yl)-6-(2-aminoethylsulfonyl)-2- (2H-tetrazol-5- yl)benzenesulfonamide::US10227331, Example 72 Metallo-beta-lactamase type 2 0.322 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367885 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367885&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135150197 402364745 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726580 NCCS(=O)(=O)c1ccc(-c2cccc3cc(N)ncc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C18H18N8O4S2/c19-6-7-31(27,28)14-5-4-12(11-3-1-2-10-8-15(20)22-9-13(10)11)16(17(14)32(21,29)30)18-23-25-26-24-18/h1-5,8-9H,6-7,19H2,(H2,20,22)(H2,21,29,30)(H,23,24,25,26) UHFCOOBYWTVRBZ-UHFFFAOYSA-N 367886 6-(2-aminoethylsulfonyl)-3-(3- aminoisoquinolin-8-yl)-2-(2H- tetrazol-5-yl)benzenesulfonamide::US10227331, Example 73 Metallo-beta-lactamase type 2 0.214 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367886 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367886&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135149540 402364746 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726583 COc1ccc(CN(Cc2ccc(OC)cc2)S(=O)(=O)c2c(ccc(I)c2-c2nnn(Cc3ccc(OC)cc3)n2)S(=O)(=O)CCCNC(=O)OC(C)(C)C)cc1 InChI=1S/C39H45IN6O9S2/c1-39(2,3)55-38(47)41-22-7-23-56(48,49)34-21-20-33(40)35(37-42-44-46(43-37)26-29-12-18-32(54-6)19-13-29)36(34)57(50,51)45(24-27-8-14-30(52-4)15-9-27)25-28-10-16-31(53-5)17-11-28/h8-21H,7,22-26H2,1-6H3,(H,41,47) LHXGHTSWNSQAAT-UHFFFAOYSA-N 367887 US10227331, Example 74::tert-butyl (3-((2-(N,N-bis(4- methoxybenzyl)sulfamoyl)-4- iodo-3-(2-(4-methoxybenzyl)- 2H-tetrazol-5- yl)phenyl)sulfonyl)propyl) carbamate Metallo-beta-lactamase type 2 0.989 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367887 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367887&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135165649 402364747 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726781 NCCS(=O)(=O)c1ccc(-c2ccc3CNC(=O)c3c2)c(-c2nnn[nH]2)c1S(N)(=O)=O InChI=1S/C17H17N7O5S2/c18-5-6-30(26,27)13-4-3-11(9-1-2-10-8-20-17(25)12(10)7-9)14(15(13)31(19,28)29)16-21-23-24-22-16/h1-4,7H,5-6,8,18H2,(H,20,25)(H2,19,28,29)(H,21,22,23,24) YEMQEJOOVDOKCJ-UHFFFAOYSA-N 367953 2-((4-(3-oxoisoindolin- 5-yl)-2-sulfamoyl-3- (1H-tetrazol-5- yl)phenyl)sulfonyl) ethanaminium 2,2,2- trifluoroacetate::US10227331, Example 140 Metallo-beta-lactamase type 2 0.488 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367953 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367953&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135150185 402364813 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726784 NCCS(=O)(=O)c1ccc(-c2ccnc(N)c2)c(-c2nnn[nH]2)c1S(N)(=O)=O InChI=1S/C14H16N8O4S2/c15-4-6-27(23,24)10-2-1-9(8-3-5-18-11(16)7-8)12(13(10)28(17,25)26)14-19-21-22-20-14/h1-3,5,7H,4,6,15H2,(H2,16,18)(H2,17,25,26)(H,19,20,21,22) JTEUILWIBGYUEN-UHFFFAOYSA-N 367954 2-((4-(2-aminopyridin- 4-yl)-2-sulfamoyl-3- (1H-tetrazol-5- yl)phenyl)sulfonyl) ethanaminium 2,2,2- trifluoroacetate::US10227331, Example 141 Metallo-beta-lactamase type 2 4.89 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367954 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367954&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135149864 402364814 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726787 NCCS(=O)(=O)c1ccc(-c2ccnc3[nH]ccc23)c(-c2nnn[nH]2)c1S(N)(=O)=O InChI=1S/C16H16N8O4S2/c17-5-8-29(25,26)12-2-1-10(9-3-6-19-15-11(9)4-7-20-15)13(14(12)30(18,27)28)16-21-23-24-22-16/h1-4,6-7H,5,8,17H2,(H,19,20)(H2,18,27,28)(H,21,22,23,24) FCGGZNTVOHRIDL-UHFFFAOYSA-N 367955 2-((4-(1H-pyrrolo[2,3- b]pyridin-4-yl)-2- sulfamoyl-3-(1H- tetrazol-5- yl)phenyl)sulfonyl) ethanaminium 2,2,2- trifluoroacetate::US10227331, Example 142 Metallo-beta-lactamase type 2 0.517 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367955 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367955&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135149642 402364815 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726790 NCCS(=O)(=O)c1ccc(-c2cncc(CO)c2)c(-c2nnn[nH]2)c1S(N)(=O)=O InChI=1S/C15H17N7O5S2/c16-3-4-28(24,25)12-2-1-11(10-5-9(8-23)6-18-7-10)13(14(12)29(17,26)27)15-19-21-22-20-15/h1-2,5-7,23H,3-4,8,16H2,(H2,17,26,27)(H,19,20,21,22) WJSHHJUONVEMFR-UHFFFAOYSA-N 367956 2-((4-(5- (hydroxymethyl)pyridin- 3-yl)-2-sulfamoyl-3- (1H-tetrazol-5- yl)phenyl)sulfonyl) ethanaminium 2,2,2- trifluoroacetate::US10227331, Example 143 Metallo-beta-lactamase type 2 8.83 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367956 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367956&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135150291 402364816 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727102 NS(=O)(=O)c1c(ccc(-c2cccc(c2)S(=O)=O)c1-c1nn[nH]n1)S(=O)(=O)C1CNC1 InChI=1S/C16H16N6O6S3/c17-31(27,28)15-13(30(25,26)11-7-18-8-11)5-4-12(14(15)16-19-21-22-20-16)9-2-1-3-10(6-9)29(23)24/h1-6,11,18,29H,7-8H2,(H2,17,27,28)(H,19,20,21,22) MLPJOYZMIZRKOA-UHFFFAOYSA-N 368060 4-(Azetidin-3-ylsulfonyl)-2-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-3,3′-disulfonamide::US10227331, Example 247 Metallo-beta-lactamase type 2 3.24 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368060 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368060&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135165670 402364917 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727105 Nc1ncc(-c2ccc(c(c2-c2nn[nH]n2)S(N)(=O)=O)S(=O)(=O)C2CNC2)c2cccnc12 InChI=1S/C18H17N9O4S2/c19-17-15-11(2-1-5-22-15)12(8-23-17)10-3-4-13(32(28,29)9-6-21-7-9)16(33(20,30)31)14(10)18-24-26-27-25-18/h1-5,8-9,21H,6-7H2,(H2,19,23)(H2,20,30,31)(H,24,25,26,27) BBYQXILMZGYDPM-UHFFFAOYSA-N 368061 3-(8-Amino-1,7- naphthyridin-5-yl)-6- (azetidin-3-ylsulfonyl)-2- (2H-tetrazol-5-yl) benzenesulfonamide::US10227331, Example 248 Metallo-beta-lactamase type 2 2.09 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368061 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368061&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 145713709 402364918 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727108 NS(=O)(=O)c1c(ccc(-c2cccc3c2C(=O)NS3(=O)=O)c1-c1nn[nH]n1)S(=O)(=O)C1CNC1 InChI=1S/C17H15N7O7S3/c18-33(28,29)15-12(32(26,27)8-6-19-7-8)5-4-10(14(15)16-20-23-24-21-16)9-2-1-3-11-13(9)17(25)22-34(11,30)31/h1-5,8,19H,6-7H2,(H,22,25)(H2,18,28,29)(H,20,21,23,24) BNRDLDZFQNXQEV-UHFFFAOYSA-N 368062 6-(Azetidin-3-ylsulfonyl)-3-(1,1-dioxido-3-oxo-2,3-dihydrobenzo[d]isothiazol-4-yl)-2-(2H-tetrazol-5-yl)benzenesulfonamide::US10227331, Example 249 Metallo-beta-lactamase type 2 0.263 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368062 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368062&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135149721 402364919 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727111 Nc1nc2c(cccc2s1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)c1cccc(c1)C(F)(F)F InChI=1S/C21H14F3N7O4S3/c22-21(23,24)10-3-1-4-11(9-10)37(32,33)15-8-7-12(13-5-2-6-14-17(13)27-20(25)36-14)16(18(15)38(26,34)35)19-28-30-31-29-19/h1-9H,(H2,25,27)(H2,26,34,35)(H,28,29,30,31) SYOOWKRSWUKOOU-UHFFFAOYSA-N 368063 3-(2-Aminobenzo[d]thiazol-4-yl)-2-(2H-tetrazol-5-yl)-6-((3-(trifluoromethyl)phenyl)sulfonyl)benzenesulfonamide::US10227331, Example 250 Metallo-beta-lactamase type 2 0.820 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368063 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368063&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 145713710 402364920 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727279 NCCc1nc2c(cccc2[nH]1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)CCN InChI=1S/C18H21N9O4S2/c19-7-6-14-22-12-3-1-2-11(16(12)23-14)10-4-5-13(32(28,29)9-8-20)17(33(21,30)31)15(10)18-24-26-27-25-18/h1-5H,6-9,19-20H2,(H,22,23)(H2,21,30,31)(H,24,25,26,27) LGNIXDPUPQDCIL-UHFFFAOYSA-N 368119 3-(2-(2-aminoethyl)-1H- benzo[d]imidazol-4-yl)- 6-((2-aminoethyl) sulfonyl)-2- (2H-tetrazol-5-yl) benzenesulfonamide::US10227331, Example 306 Metallo-beta-lactamase type 2 2.84 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368119 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368119&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 145713721 402364971 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727282 NCCS(=O)(=O)c1ccc(-c2cccc3[nH]c(nc23)C(F)(F)CN)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C18H19F2N9O4S2/c19-18(20,8-22)17-24-11-3-1-2-10(14(11)25-17)9-4-5-12(34(30,31)7-6-21)15(35(23,32)33)13(9)16-26-28-29-27-16/h1-5H,6-8,21-22H2,(H,24,25)(H2,23,32,33)(H,26,27,28,29) WOEBXQWHXAFLRS-UHFFFAOYSA-N 368120 3-(2-(2-amino-1,1- difluoroethyl)-1H- benzo[d]imidazol-4-yl)- 6-((2-aminoethyl) sulfonyl)-2- (2H-tetrazol-5-yl) benzenesulfonamide::US10227331, Example 307 Metallo-beta-lactamase type 2 0.087 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368120 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368120&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 145713722 402364972 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727285 NCCS(=O)(=O)c1ccc(-c2cccc3[nH]c(nc23)C(F)(F)F)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C17H15F3N8O4S2/c18-17(19,20)16-23-10-3-1-2-9(13(10)24-16)8-4-5-11(33(29,30)7-6-21)14(34(22,31)32)12(8)15-25-27-28-26-15/h1-5H,6-7,21H2,(H,23,24)(H2,22,31,32)(H,25,26,27,28) JCFOWELOGBNWID-UHFFFAOYSA-N 368121 6-((2-aminoethyl)sulfonyl)-2-(2H-tetrazol-5-yl)-3-(2-(trifluoromethyl)-1H-benzo[d]imidazol-4-yl)benzenesulfonamide::US10227331, Example 308 Metallo-beta-lactamase type 2 0.560 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368121 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368121&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 145713723 402364973 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727288 NS(=O)(=O)c1c(ccc(-c2cccc3sc(O)nc23)c1-c1nn[nH]n1)S(=O)(=O)C1CNC1 InChI=1S/C17H15N7O5S3/c18-32(28,29)15-12(31(26,27)8-6-19-7-8)5-4-9(13(15)16-21-23-24-22-16)10-2-1-3-11-14(10)20-17(25)30-11/h1-5,8,19H,6-7H2,(H,20,25)(H2,18,28,29)(H,21,22,23,24) OWYRQZRFQZBAFF-UHFFFAOYSA-N 368122 6-(azetidin-3-ylsulfonyl)-3-(2-hydroxybenzo[d]thiazol-4-yl)-2-(2H-tetrazol-5-yl)benzenesulfonamide::US10227331, Example 309 Metallo-beta-lactamase type 2 0.256 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368122 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368122&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 145713724 402364974 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726586 COc1ccc(CN(Cc2ccc(OC)cc2)S(=O)(=O)c2c(ccc(I)c2-c2nnn(Cc3ccc(OC)cc3)n2)S(=O)(=O)C[C@H](C)NC(=O)OC(C)(C)C)cc1 InChI=1S/C39H45IN6O9S2/c1-26(41-38(47)55-39(2,3)4)25-56(48,49)34-21-20-33(40)35(37-42-44-46(43-37)24-29-12-18-32(54-7)19-13-29)36(34)57(50,51)45(22-27-8-14-30(52-5)15-9-27)23-28-10-16-31(53-6)17-11-28/h8-21,26H,22-25H2,1-7H3,(H,41,47)/t26-/m0/s1 OQDQJELEHDCHRM-SANMLTNESA-N 367888 (S)-tert-butyl (1-((2-(N,N-bis(4- methoxybenzyl)sulfamoyl)-4- iodo-3-(2-(4-methoxybenzyl)- 2H-tetrazol-5- yl)phenyl)sulfonyl)propan-2- yl)carbamate::US10227331, Example 75 Metallo-beta-lactamase type 2 0.433 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367888 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367888&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 140880936 402364748 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726589 COc1ccc(CN(Cc2ccc(OC)cc2)S(=O)(=O)c2c(ccc(I)c2-c2nnn(Cc3ccc(OC)cc3)n2)S(=O)(=O)[C@H]2C[C@@H](CO)N(C2)C(=O)OCc2ccccc2)cc1 InChI=1S/C44H45IN6O10S2/c1-58-35-15-9-30(10-16-35)24-49(25-31-11-17-36(59-2)18-12-31)63(56,57)42-40(22-21-39(45)41(42)43-46-48-51(47-43)26-32-13-19-37(60-3)20-14-32)62(54,55)38-23-34(28-52)50(27-38)44(53)61-29-33-7-5-4-6-8-33/h4-22,34,38,52H,23-29H2,1-3H3/t34-,38-/m0/s1 TUYZDBKNNCUCAC-UVNLRBHVSA-N 367889 (2S,4S)-benzyl 4-((2-(N,N- bis(4- methoxybenzyl)sulfamoyl)-4- iodo-3-(2-(4-methoxybenzyl)- 2H-tetrazol-5- yl)phenyl)sulfonyl)-2- (hydroxymethyl)pyrrolidine-1- carboxylate::US10227331, Example 76 Metallo-beta-lactamase type 2 0.258 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367889 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367889&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135149723 402364749 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726592 COc1ccc(CN(Cc2ccc(OC)cc2)S(=O)(=O)c2c(ccc(I)c2-c2nnn(Cc3ccc(OC)cc3)n2)S(=O)(=O)C[C@@H](CO)NC(=O)OC(C)(C)C)cc1 InChI=1S/C39H45IN6O10S2/c1-39(2,3)56-38(48)41-29(24-47)25-57(49,50)34-20-19-33(40)35(37-42-44-46(43-37)23-28-11-17-32(55-6)18-12-28)36(34)58(51,52)45(21-26-7-13-30(53-4)14-8-26)22-27-9-15-31(54-5)16-10-27/h7-20,29,47H,21-25H2,1-6H3,(H,41,48)/t29-/m1/s1 YCTFLGSNMMJIGK-GDLZYMKVSA-N 367890 (R)-tert-butyl (1-((2-(N,N- bis(4- methoxybenzyl)sulfamoyl)-4- iodo-3-(2-(4-methoxybenzyl)- 2H-tetrazol-5- yl)phenyl)sulfonyl)-3- hydroxypropan-2-yl)carbamate::US10227331, Example 77 Metallo-beta-lactamase type 2 1.13 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367890 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367890&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 140880830 402364750 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726595 COc1ccc(CN(Cc2ccc(OC)cc2)S(=O)(=O)c2c(ccc(I)c2-c2nnn(Cc3ccc(OC)cc3)n2)S(=O)(=O)C[C@H](CO)NC(=O)OC(C)(C)C)cc1 InChI=1S/C39H45IN6O10S2/c1-39(2,3)56-38(48)41-29(24-47)25-57(49,50)34-20-19-33(40)35(37-42-44-46(43-37)23-28-11-17-32(55-6)18-12-28)36(34)58(51,52)45(21-26-7-13-30(53-4)14-8-26)22-27-9-15-31(54-5)16-10-27/h7-20,29,47H,21-25H2,1-6H3,(H,41,48)/t29-/m0/s1 YCTFLGSNMMJIGK-LJAQVGFWSA-N 367891 (S)-tert-butyl (1-((2-(N,N-bis(4- methoxybenzyl)sulfamoyl)-4- iodo-3-(2-(4-methoxybenzyl)- 2H-tetrazol-5- yl)phenyl)sulfonyl)-3- hydroxypropan-2-yl)carbamate::US10227331, Example 78 Metallo-beta-lactamase type 2 0.441 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367891 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367891&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 140880857 402364751 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726598 COc1ccc(CN(Cc2ccc(OC)cc2)S(=O)(=O)c2c(ccc(I)c2-c2nnn(Cc3ccc(OC)cc3)n2)S(=O)(=O)C[C@@H](CNC(=O)OC(C)(C)C)NC(=O)OC(C)(C)C)cc1 InChI=1S/C44H54IN7O11S2/c1-43(2,3)62-41(53)46-24-32(47-42(54)63-44(4,5)6)28-64(55,56)37-23-22-36(45)38(40-48-50-52(49-40)27-31-14-20-35(61-9)21-15-31)39(37)65(57,58)51(25-29-10-16-33(59-7)17-11-29)26-30-12-18-34(60-8)19-13-30/h10-23,32H,24-28H2,1-9H3,(H,46,53)(H,47,54)/t32-/m1/s1 SLBQNYOZLYKLQU-JGCGQSQUSA-N 367892 (R)-di-tert-butyl (3-((2-(N,N- bis(4- methoxybenzyl)sulfamoyl)-4- iodo-3-(2-(4-methoxybenzyl)- 2H-tetrazol-5- yl)phenyl)sulfonyl)propane- 1,2-diyl)dicarbamate::US10227331, Example 79 Metallo-beta-lactamase type 2 0.241 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367892 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367892&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 145713681 402364752 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726793 NCCS(=O)(=O)c1ccc(-c2ccc(nc2)C#N)c(-c2nnn[nH]2)c1S(N)(=O)=O InChI=1S/C15H14N8O4S2/c16-5-6-28(24,25)12-4-3-11(9-1-2-10(7-17)19-8-9)13(14(12)29(18,26)27)15-20-22-23-21-15/h1-4,8H,5-6,16H2,(H2,18,26,27)(H,20,21,22,23) RTOGEAVKRIHCMB-UHFFFAOYSA-N 367957 2-((4-(6-cyanopyridin-3- yl)-2-sulfamoyl-3-(1H- tetrazol-5- yl)phenyl)sulfonyl) ethanaminium 2,2,2- trifluoroacetate::US10227331, Example 144 Metallo-beta-lactamase type 2 5.59 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367957 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367957&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135149696 402364817 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726796 NCCS(=O)(=O)c1ccc(-c2ccc(CO)nc2)c(-c2nnn[nH]2)c1S(N)(=O)=O InChI=1S/C15H17N7O5S2/c16-5-6-28(24,25)12-4-3-11(9-1-2-10(8-23)18-7-9)13(14(12)29(17,26)27)15-19-21-22-20-15/h1-4,7,23H,5-6,8,16H2,(H2,17,26,27)(H,19,20,21,22) CQGBMLAUZVALKD-UHFFFAOYSA-N 367958 2-((4-(6- (hydroxymethyl)pyridin- 3-yl)-2-sulfamoyl-3- (1H-tetrazol-5- yl)phenyl)sulfonyl) ethanaminium 2,2,2- trifluoroacetate::US10227331, Example 145 Metallo-beta-lactamase type 2 4.84 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367958 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367958&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135150294 402364818 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726799 NCCS(=O)(=O)c1ccc(-c2ccc3nncn3c2)c(-c2nnn[nH]2)c1S(N)(=O)=O InChI=1S/C15H15N9O4S2/c16-5-6-29(25,26)11-3-2-10(9-1-4-12-19-18-8-24(12)7-9)13(14(11)30(17,27)28)15-20-22-23-21-15/h1-4,7-8H,5-6,16H2,(H2,17,27,28)(H,20,21,22,23) FNMCSPGLFGKJKP-UHFFFAOYSA-N 367959 2-((4- ([1,2,4]triazolo[4,3- a]pyridin-6-yl)-2- sulfamoyl-3-(1H- tetrazol-5- yl)phenyl)sulfonyl) ethanaminium 2,2,2- trifluoroacetate::US10227331, Example 146 Metallo-beta-lactamase type 2 44.4 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367959 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367959&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135149763 402364819 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726802 NCCS(=O)(=O)c1ccc(-c2cccc(n2)N2CCCC2=O)c(-c2nnn[nH]2)c1S(N)(=O)=O InChI=1S/C18H20N8O5S2/c19-8-10-32(28,29)13-7-6-11(16(17(13)33(20,30)31)18-22-24-25-23-18)12-3-1-4-14(21-12)26-9-2-5-15(26)27/h1,3-4,6-7H,2,5,8-10,19H2,(H2,20,30,31)(H,22,23,24,25) WJRFPYJHMHYVKN-UHFFFAOYSA-N 367960 2-((4-(6-(2- oxopyrrolidin-1- yl)pyridin-2-yl)-2- sulfamoyl-3-(1H- tetrazol-5- yl)phenyl)sulfonyl) ethanaminium 2,2,2- trifluoroacetate::US10227331, Example 147 Metallo-beta-lactamase type 2 4.10 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367960 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367960&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135150206 402364820 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727114 Nc1nc2c(ccc(F)c2[nH]1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)C1CNC1 InChI=1S/C17H16FN9O4S2/c18-10-3-1-9(13-14(10)23-17(19)22-13)8-2-4-11(32(28,29)7-5-21-6-7)15(33(20,30)31)12(8)16-24-26-27-25-16/h1-4,7,21H,5-6H2,(H3,19,22,23)(H2,20,30,31)(H,24,25,26,27) SXHRVSNTABVXLT-UHFFFAOYSA-N 368064 3-(2-Amino-7-fluoro-1H-benzo[d]imidazol-4-yl)-6-(azetidin-3-ylsulfonyl)-2-(2H-tetrazol-5-yl)benzenesulfonamide::US10227331, Example 251 Metallo-beta-lactamase type 2 0.748 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368064 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368064&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124157432 402364921 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727117 COC(=O)c1nc2c(cccc2[nH]1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)C1CNC1 InChI=1S/C19H18N8O6S2/c1-33-19(28)18-22-12-4-2-3-11(15(12)23-18)10-5-6-13(34(29,30)9-7-21-8-9)16(35(20,31)32)14(10)17-24-26-27-25-17/h2-6,9,21H,7-8H2,1H3,(H,22,23)(H2,20,31,32)(H,24,25,26,27) XHUGMGXDNXSBGW-UHFFFAOYSA-N 368065 Methyl 4-(4-(azetidin-3-yl sulfonyl)-3-sulfamoyl-2-(2H-tetrazol-5-yl)phenyl)-1H-benzo[d]imidazole-2-carboxylate::US10227331, Example 252 Metallo-beta-lactamase type 2 0.423 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368065 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368065&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124157267 402364922 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727120 NS(=O)(=O)c1c(ccc(-c2cccc3[nH]c(nc23)C(O)=O)c1-c1nn[nH]n1)S(=O)(=O)C1CNC1 InChI=1S/C18H16N8O6S2/c19-34(31,32)15-12(33(29,30)8-6-20-7-8)5-4-9(13(15)16-23-25-26-24-16)10-2-1-3-11-14(10)22-17(21-11)18(27)28/h1-5,8,20H,6-7H2,(H,21,22)(H,27,28)(H2,19,31,32)(H,23,24,25,26) BBVRGNXSJPCWIQ-UHFFFAOYSA-N 368066 4-(4-(Azetidin-3-ylsulfonyl)-3-sulfamoyl-2-(2H-tetrazol-5-yl)phenyl)-1H-benzo[d]imidazole-2-carboxylic Acid::US10227331, Example 253 Metallo-beta-lactamase type 2 0.664 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368066 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368066&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124159673 402364923 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727123 NC(=O)c1nc2c(cccc2[nH]1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)C1CNC1 InChI=1S/C18H17N9O5S2/c19-16(28)18-22-11-3-1-2-10(14(11)23-18)9-4-5-12(33(29,30)8-6-21-7-8)15(34(20,31)32)13(9)17-24-26-27-25-17/h1-5,8,21H,6-7H2,(H2,19,28)(H,22,23)(H2,20,31,32)(H,24,25,26,27) JPGVCRNGRUFKTN-UHFFFAOYSA-N 368067 4-(4-(Azetidin-3-ylsulfonyl)-3-sulfamoyl-2-(2H-tetrazol-5-yl)phenyl)-1H-benzo[d]imidazole-2-carboxamide::US10227331, Example 254 Metallo-beta-lactamase type 2 0.748 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368067 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368067&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135149976 402364924 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727291 Nc1ncccc1-c1cc(ccn1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)C1CNC1 InChI=1S/C20H19N9O4S2/c21-19-14(2-1-6-25-19)15-8-11(5-7-24-15)13-3-4-16(34(30,31)12-9-23-10-12)18(35(22,32)33)17(13)20-26-28-29-27-20/h1-8,12,23H,9-10H2,(H2,21,25)(H2,22,32,33)(H,26,27,28,29) OYHHRVSSXGIGIM-UHFFFAOYSA-N 368123 3-(2′-Amino-[2,3′-bipyridin]-4-yl)-6-(azetidin-3-ylsulfonyl)-2-(1H-tetrazol-5-yl)benzenesulfonamide::US10227331, Example 310 Metallo-beta-lactamase type 2 2.30 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368123 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368123&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 145713725 402364975 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727294 Nc1cc(ccn1)-c1cc(ccn1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)C1CNC1 InChI=1S/C20H19N9O4S2/c21-17-8-12(4-6-25-17)15-7-11(3-5-24-15)14-1-2-16(34(30,31)13-9-23-10-13)19(35(22,32)33)18(14)20-26-28-29-27-20/h1-8,13,23H,9-10H2,(H2,21,25)(H2,22,32,33)(H,26,27,28,29) DHNQXBXGPDQJNE-UHFFFAOYSA-N 368124 3-(2′-amino-[2,4′-bipyridin]-4-yl)-6-(azetidin-3-ylsulfonyl)-2-(1H-tetrazol-5-yl)benzenesulfonamide::US10227331, Example 311 Metallo-beta-lactamase type 2 2.32 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368124 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368124&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 145713726 402364976 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727297 NC[C@@H](O)CS(=O)(=O)c1ccc(-c2cccc3[nH]c(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C17H17N9O5S2/c18-6-8(27)7-32(28,29)12-5-4-9(10-2-1-3-11-14(10)22-17(19)21-11)13(15(12)33(20,30)31)16-23-25-26-24-16/h1-5,8,27H,6-7,18H2,(H2,19,21)(H2,20,30,31)/b10-9+/t8-/m1/s1 JZRMNEHCCUZTST-KGSKPCQNSA-N 368125 3-(2-amino-1H-benzo[d]imidazol-4-yl)-6-((R)-3-amino-2-hydroxypropylsulfonyl)-2-(2H-tetrazol-5-yl)benzenesulfonamide::US10227331, Example 312 Metallo-beta-lactamase type 2 0.430 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368125 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368125&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135149846 402364977 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727300 NCCS(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C16H16N8O4S3/c17-6-7-30(25,26)11-5-4-8(9-2-1-3-10-13(9)20-16(18)29-10)12(14(11)31(19,27)28)15-21-23-24-22-15/h1-5H,6-7,17H2,(H2,18,20)(H2,19,27,28)(H,21,22,23,24) YUKOXBMPBHMICW-UHFFFAOYSA-N 368126 3-(2-aminobenzo[d]thiazol-4-yl)-6-((2-aminoethyl)sulfonyl)-2-(2H-tetrazol-5-yl)benzenesulfonamide::US10227331, Example 313 Metallo-beta-lactamase type 2 0.257 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368126 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368126&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124157629 402364978 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726364 Nc1nc2cc(ccc2[nH]1)-c1ccc(SC2CNC2)c(c1-c1nn[nH]n1)S(N)(=O)=O InChI=1S/C17H17N9O2S2/c18-17-21-11-3-1-8(5-12(11)22-17)10-2-4-13(29-9-6-20-7-9)15(30(19,27)28)14(10)16-23-25-26-24-16/h1-5,9,20H,6-7H2,(H3,18,21,22)(H2,19,27,28)(H,23,24,25,26) RPKHGAICDRCRBU-UHFFFAOYSA-N 367686 3-(2-amino-1H-benzo[d]imidazol-5-yl)-6-(azetidin-3-ylthio)-2-(2H-tetrazol-5-yl)benzenesulfonamide::US10227331, Example 1 Metallo-beta-lactamase type 2 422 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367686 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367686&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 145713514 402364548 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726367 Nc1nc2c(cccc2[nH]1)-c1ccc(SC2CNC2)c(c1-c1nn[nH]n1)S(N)(=O)=O InChI=1S/C17H17N9O2S2/c18-17-21-11-3-1-2-10(14(11)22-17)9-4-5-12(29-8-6-20-7-8)15(30(19,27)28)13(9)16-23-25-26-24-16/h1-5,8,20H,6-7H2,(H3,18,21,22)(H2,19,27,28)(H,23,24,25,26) HJSZNCBIEXWQLR-UHFFFAOYSA-N 367687 3-(2-amino-1H-benzo[d]imidazol-4-yl)-6-(azetidin-3-ylthio)-2-(2H-tetrazol-5-yl)benzenesulfonamide::US10227331, Example 2 Metallo-beta-lactamase type 2 75.8 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367687 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367687&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 145713515 402364549 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726370 Nc1nc2cccc(-c3ccc(SC4CCNCC4)c(c3-c3nn[nH]n3)S(N)(=O)=O)c2[nH]1 InChI=1S/C19H21N9O2S2/c20-19-23-13-3-1-2-12(16(13)24-19)11-4-5-14(31-10-6-8-22-9-7-10)17(32(21,29)30)15(11)18-25-27-28-26-18/h1-5,10,22H,6-9H2,(H3,20,23,24)(H2,21,29,30)(H,25,26,27,28) MUYWUVFYUFGJFG-UHFFFAOYSA-N 367688 3-(2-amino-3H-benzo[d]imidazol-4-yl)-6-(piperidin-4-ylthio)-2-(2H-tetrazol-5-yl)benzenesulfonamide::US10227331, Example 3 Metallo-beta-lactamase type 2 109 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367688 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367688&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 145713516 402364550 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726601 COc1ccc(CN(Cc2ccc(OC)cc2)S(=O)(=O)c2c(ccc(I)c2-c2nnn(Cc3ccc(OC)cc3)n2)S(=O)(=O)C[C@@H](CNC(=O)OC(C)(C)C)NC(=O)OCc2ccccc2)cc1 InChI=1S/C47H52IN7O11S2/c1-47(2,3)66-45(56)49-26-36(50-46(57)65-30-35-10-8-7-9-11-35)31-67(58,59)41-25-24-40(48)42(44-51-53-55(52-44)29-34-16-22-39(64-6)23-17-34)43(41)68(60,61)54(27-32-12-18-37(62-4)19-13-32)28-33-14-20-38(63-5)21-15-33/h7-25,36H,26-31H2,1-6H3,(H,49,56)(H,50,57)/t36-/m1/s1 LBVMNSWANINHPA-PSXMRANNSA-N 367893 (R)-benzyl tert-butyl (3-((2- (N,N-bis(4- methoxybenzyl)sulfamoyl)-4- iodo-3-(2-(4-methoxybenzyl)- 2H-tetrazol-5- yl)phenyl)sulfonyl)propane- 1,2-diyl)dicarbamate::US10227331, Example 80 Metallo-beta-lactamase type 2 0.085 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367893 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367893&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135165654 402364753 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726604 COc1ccc(CN(Cc2ccc(OC)cc2)S(=O)(=O)c2c(ccc(I)c2-c2nnn(Cc3ccc(OC)cc3)n2)S(=O)(=O)C[C@H](CNC(=O)OC(C)(C)C)NC(=O)OC(C)(C)C)cc1 InChI=1S/C44H54IN7O11S2/c1-43(2,3)62-41(53)46-24-32(47-42(54)63-44(4,5)6)28-64(55,56)37-23-22-36(45)38(40-48-50-52(49-40)27-31-14-20-35(61-9)21-15-31)39(37)65(57,58)51(25-29-10-16-33(59-7)17-11-29)26-30-12-18-34(60-8)19-13-30/h10-23,32H,24-28H2,1-9H3,(H,46,53)(H,47,54)/t32-/m0/s1 SLBQNYOZLYKLQU-YTTGMZPUSA-N 367894 6-((2-aminoethyl)sulfonyl)-3-(2-aminothiazolo[5,4-c]pyridin-7-yl)-2-(2H-tetrazol-5-yl)benzenesulfonamide hydrochloride::US10227331, Example 81 Metallo-beta-lactamase type 2 0.266 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367894 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367894&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135165653 402364754 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726607 CC(=O)Nc1nc2c(cccc2s1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)CCN InChI=1S/C18H18N8O5S3/c1-9(27)21-18-22-15-11(3-2-4-12(15)32-18)10-5-6-13(33(28,29)8-7-19)16(34(20,30)31)14(10)17-23-25-26-24-17/h2-6H,7-8,19H2,1H3,(H2,20,30,31)(H,21,22,27)(H,23,24,25,26) BSJIMTQYMTUCOT-UHFFFAOYSA-N 367895 N-(4-(4-(2-aminoethylsulfonyl)-3-sulfamoyl-2-(2H-tetrazol-5-yl)phenyl)benzo[d]thiazol-2-yl)acetamide::US10227331, Example 82 Metallo-beta-lactamase type 2 0.194 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367895 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367895&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124157644 402364755 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726610 CS(=O)(=O)Nc1nc2c(cccc2s1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)CCN InChI=1S/C17H18N8O6S4/c1-33(26,27)23-17-20-14-10(3-2-4-11(14)32-17)9-5-6-12(34(28,29)8-7-18)15(35(19,30)31)13(9)16-21-24-25-22-16/h2-6H,7-8,18H2,1H3,(H,20,23)(H2,19,30,31)(H,21,22,24,25) BKSOPTPOSNYQLR-UHFFFAOYSA-N 367896 6-(2-aminoethylsulfonyl)-3-(2- (methylsulfonamido)benzo[d] thiazol-4-yl)-2-(2H-tetrazol-5- yl)benzenesulfonamide::US10227331, Example 83 Metallo-beta-lactamase type 2 0.341 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367896 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367896&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135149975 402364756 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726613 CCOC(=O)Nc1nc2c(cccc2s1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)CCN InChI=1S/C19H20N8O6S3/c1-2-33-19(28)23-18-22-15-11(4-3-5-12(15)34-18)10-6-7-13(35(29,30)9-8-20)16(36(21,31)32)14(10)17-24-26-27-25-17/h3-7H,2,8-9,20H2,1H3,(H2,21,31,32)(H,22,23,28)(H,24,25,26,27) FPLSJIGZPDKQLR-UHFFFAOYSA-N 367897 US10227331, Example 84::ethyl 4-(4-(2- aminoethylsulfonyl)-3- sulfamoyl-2-(2H-tetrazol-5- yl)phenyl)benzo[d]thiazol-2- ylcarbamate Metallo-beta-lactamase type 2 0.145 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367897 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367897&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135149779 402364757 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726751 Cn1ncc2cccc(-c3ccc(c(c3-c3nnn[nH]3)S(N)(=O)=O)S(=O)(=O)C3CNC3)c12 InChI=1S/C18H18N8O4S2/c1-26-16-10(7-21-26)3-2-4-13(16)12-5-6-14(31(27,28)11-8-20-9-11)17(32(19,29)30)15(12)18-22-24-25-23-18/h2-7,11,20H,8-9H2,1H3,(H2,19,29,30)(H,22,23,24,25) ICDUZFCCJFOXBA-UHFFFAOYSA-N 367943 3-((4-(1-methyl-1H- indazol-7-yl)-2- sulfamoyl-3-(1H- tetrazol-5- yl)phenyl)sulfonyl)azetidin- 1-ium 2,2,2- trifluoroacetate::US10227331, Example 130 Metallo-beta-lactamase type 2 1.69 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367943 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367943&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135150271 402364803 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726754 NS(=O)(=O)c1c(ccc(-c2ccc3ccncc3c2)c1-c1nnn[nH]1)S(=O)(=O)C1CNC1 InChI=1S/C19H17N7O4S2/c20-32(29,30)18-16(31(27,28)14-9-22-10-14)4-3-15(17(18)19-23-25-26-24-19)12-2-1-11-5-6-21-8-13(11)7-12/h1-8,14,22H,9-10H2,(H2,20,29,30)(H,23,24,25,26) UMBRCAAADNXTCF-UHFFFAOYSA-N 367944 3-((4-(isoquinolin-7-yl)- 2-sulfamoyl-3-(1H- tetrazol-5- yl)phenyl)sulfonyl)azetidin- 1-ium 2,2,2- trifluoroacetate::US10227331, Example 131 Metallo-beta-lactamase type 2 0.510 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367944 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367944&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135149773 402364804 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726757 NCCS(=O)(=O)c1ccc(-c2ccc(nc2)C2(CNC2)C#N)c(-c2nnn[nH]2)c1S(N)(=O)=O InChI=1S/C18H19N9O4S2/c19-5-6-32(28,29)13-3-2-12(15(16(13)33(21,30)31)17-24-26-27-25-17)11-1-4-14(23-7-11)18(8-20)9-22-10-18/h1-4,7,22H,5-6,9-10,19H2,(H2,21,30,31)(H,24,25,26,27) CQHHVBRSDPQDEZ-UHFFFAOYSA-N 367945 2-((4-(6-(3- cyanoazetidin-3- yl)pyridin-3-yl)-2- sulfamoyl-3-(1H- tetrazol-5- yl)phenyl)sulfonyl) ethanaminium 2,2,2- trifluoroacetate::US10227331, Example 132 Metallo-beta-lactamase type 2 1.49 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367945 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367945&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135150172 402364805 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726760 Cc1nnc2ccc(cn12)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)CCN InChI=1S/C16H17N9O4S2/c1-9-19-20-13-5-2-10(8-25(9)13)11-3-4-12(30(26,27)7-6-17)15(31(18,28)29)14(11)16-21-23-24-22-16/h2-5,8H,6-7,17H2,1H3,(H2,18,28,29)(H,21,22,23,24) CRFKGBHGSRGFCU-UHFFFAOYSA-N 367946 2-((4-(3-methyl- [1,2,4]triazolo[4,3- a]pyridin-6-yl)-2- sulfamoyl-3-(1H- tetrazol-5- yl)phenyl)sulfonyl) ethanaminium 2,2,2- trifluoroacetate::US10227331, Example 133 Metallo-beta-lactamase type 2 29.4 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367946 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367946&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135150125 402364806 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726763 NCCS(=O)(=O)c1ccc(-c2cnc3cccnc3c2)c(-c2nnn[nH]2)c1S(N)(=O)=O InChI=1S/C17H16N8O4S2/c18-5-7-30(26,27)14-4-3-11(10-8-13-12(21-9-10)2-1-6-20-13)15(16(14)31(19,28)29)17-22-24-25-23-17/h1-4,6,8-9H,5,7,18H2,(H2,19,28,29)(H,22,23,24,25) PXYCATKEOAVCBV-UHFFFAOYSA-N 367947 2-((4-(1,5-naphthyridin- 3-yl)-2-sulfamoyl-3- (1H-tetrazol-5- yl)phenyl)sulfonyl) ethanaminium 2,2,2- trifluoroacetate::US10227331, Example 134 Metallo-beta-lactamase type 2 2.47 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367947 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367947&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135150314 402364807 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726805 NCCS(=O)(=O)c1ccc(-c2cncc3ccccc23)c(-c2nnn[nH]2)c1S(N)(=O)=O InChI=1S/C18H17N7O4S2/c19-7-8-30(26,27)15-6-5-13(14-10-21-9-11-3-1-2-4-12(11)14)16(17(15)31(20,28)29)18-22-24-25-23-18/h1-6,9-10H,7-8,19H2,(H2,20,28,29)(H,22,23,24,25) VIXCSOBWOUIQIJ-UHFFFAOYSA-N 367961 2-((4-(isoquinolin-4-yl)- 2-sulfamoyl-3-(1H- tetrazol-5- yl)phenyl)sulfonyl) ethanaminium 2,2,2- trifluoroacetate::US10227331, Example 148 Metallo-beta-lactamase type 2 0.983 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367961 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367961&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135149592 402364821 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726808 NCCS(=O)(=O)c1ccc(-c2cnc3[nH]ccc3c2)c(-c2nnn[nH]2)c1S(N)(=O)=O InChI=1S/C16H16N8O4S2/c17-4-6-29(25,26)12-2-1-11(10-7-9-3-5-19-15(9)20-8-10)13(14(12)30(18,27)28)16-21-23-24-22-16/h1-3,5,7-8H,4,6,17H2,(H,19,20)(H2,18,27,28)(H,21,22,23,24) QWKHNLFRKBVRFR-UHFFFAOYSA-N 367962 2-((4-(1H-pyrrolo[2,3- b]pyridin-5-yl)-2- sulfamoyl-3-(1H- tetrazol-5- yl)phenyl)sulfonyl) ethanaminium 2,2,2- trifluoroacetate::US10227331, Example 149 Metallo-beta-lactamase type 2 0.856 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367962 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367962&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135149799 402364822 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726811 NCCS(=O)(=O)c1ccc(-c2cccc3[nH]c(=O)[nH]c23)c(-c2nnn[nH]2)c1S(N)(=O)=O InChI=1S/C16H16N8O5S2/c17-6-7-30(26,27)11-5-4-8(9-2-1-3-10-13(9)20-16(25)19-10)12(14(11)31(18,28)29)15-21-23-24-22-15/h1-5H,6-7,17H2,(H2,18,28,29)(H2,19,20,25)(H,21,22,23,24) IXCYFKTYYYHTOW-UHFFFAOYSA-N 367963 2-((4-(2-oxo-2,3- dihydro-1H- benzo[d]imidazol-4-yl)- 2-sulfamoyl-3-(1H- tetrazol-5- yl)phenyl)sulfonyl) ethanaminium 2,2,2- trifluoroacetate::US10227331, Example 150::US10227331, Example 300 Metallo-beta-lactamase type 2 0.931 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367963 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367963&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 145713684 402364823 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726814 NCCS(=O)(=O)c1ccc(-c2ccc(cc2)-c2nn[nH]n2)c(-c2nnn[nH]2)c1S(N)(=O)=O InChI=1S/C16H16N10O4S2/c17-7-8-31(27,28)12-6-5-11(9-1-3-10(4-2-9)15-19-23-24-20-15)13(14(12)32(18,29)30)16-21-25-26-22-16/h1-6H,7-8,17H2,(H2,18,29,30)(H,19,20,23,24)(H,21,22,25,26) BYGFXACHFRCWAM-UHFFFAOYSA-N 367964 2-((3-sulfamoyl-2-(1H- tetrazol-5-yl)-4'-(2H- tetrazol-5-yl)-[1,1'- biphenyl]-4- yl)sulfonyl) ethanaminium 2,2,2- trifluoroacetate::US10227331, Example 151 Metallo-beta-lactamase type 2 0.191 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367964 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367964&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135149632 402364824 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726817 NCCS(=O)(=O)c1ccc(-c2cnn3CCCc23)c(-c2nnn[nH]2)c1S(N)(=O)=O InChI=1S/C15H18N8O4S2/c16-5-7-28(24,25)12-4-3-9(10-8-18-23-6-1-2-11(10)23)13(14(12)29(17,26)27)15-19-21-22-20-15/h3-4,8H,1-2,5-7,16H2,(H2,17,26,27)(H,19,20,21,22) VNVLRRFGXMEVIZ-UHFFFAOYSA-N 367965 2-((4-(5,6-dihydro-4H- pyrrolo[1,2-b]pyrazol-3- yl)-2-sulfamoyl-3-(1H- tetrazol-5- yl)phenyl)sulfonyl) ethanaminium 2,2,2- trifluoroacetate::US10227331, Example 152 Metallo-beta-lactamase type 2 4.79 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367965 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367965&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135150201 402364825 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727126 CNC(=O)c1nc2c(cccc2[nH]1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)C1CNC1 InChI=1S/C19H19N9O5S2/c1-21-19(29)18-23-12-4-2-3-11(15(12)24-18)10-5-6-13(34(30,31)9-7-22-8-9)16(35(20,32)33)14(10)17-25-27-28-26-17/h2-6,9,22H,7-8H2,1H3,(H,21,29)(H,23,24)(H2,20,32,33)(H,25,26,27,28) OVPLLYNAOGNJMZ-UHFFFAOYSA-N 368068 4-(4-(Azetidin-3- ylsulfonyl)-3-sulfamoyl- 2-(2H-tetrazol-5- yl)phenyl)-N-methyl- 1H-benzo[d]imidazole-2- carboxamide::US10227331, Example 255 Metallo-beta-lactamase type 2 1.66 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368068 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368068&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 145713711 402364925 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727129 COC(=O)CNC(=O)c1nc2c(cccc2[nH]1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)C1CNC1 InChI=1S/C21H21N9O7S2/c1-37-15(31)9-24-21(32)20-25-13-4-2-3-12(17(13)26-20)11-5-6-14(38(33,34)10-7-23-8-10)18(39(22,35)36)16(11)19-27-29-30-28-19/h2-6,10,23H,7-9H2,1H3,(H,24,32)(H,25,26)(H2,22,35,36)(H,27,28,29,30) FQGFBVZPDQJURE-UHFFFAOYSA-N 368069 Methyl (4-(4-(azetidin- 3-ylsulfonyl)-3- sulfamoyl-2-(2H- tetrazol-5-yl)phenyl)- 1H-benzo[d]imidazole- 2-carbonyl)glycinate::US10227331, Example 256 Metallo-beta-lactamase type 2 0.999 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368069 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368069&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 145713712 402364926 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727132 NS(=O)(=O)c1c(ccc(-c2cccc3[nH]c(nc23)C(=O)NCC(O)=O)c1-c1nn[nH]n1)S(=O)(=O)C1CNC1 InChI=1S/C20H19N9O7S2/c21-38(35,36)17-13(37(33,34)9-6-22-7-9)5-4-10(15(17)18-26-28-29-27-18)11-2-1-3-12-16(11)25-19(24-12)20(32)23-8-14(30)31/h1-5,9,22H,6-8H2,(H,23,32)(H,24,25)(H,30,31)(H2,21,35,36)(H,26,27,28,29) NSWXJPMAEULDIG-UHFFFAOYSA-N 368070 (4-(4-(azetidin-3-yl sulfonyl)-3-sulfamoyl-2-(2H-tetrazol-5-yl)phenyl)-1H-benzo[d]imidazole-2-carbonyl)glycine::US10227331, Example 257 Metallo-beta-lactamase type 2 1.20 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368070 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368070&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124159639 402364927 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727135 Nc1nc2c(cccc2s1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)CCN1CCOCC1=O InChI=1S/C20H20N8O6S3/c21-20-23-17-12(2-1-3-13(17)35-20)11-4-5-14(18(37(22,32)33)16(11)19-24-26-27-25-19)36(30,31)9-7-28-6-8-34-10-15(28)29/h1-5H,6-10H2,(H2,21,23)(H2,22,32,33)(H,24,25,26,27) RQRSMBMLWVQUAI-UHFFFAOYSA-N 368071 3-(2-Aminobenzo[d]thiazol-4-yl)-6-((2-morpholinoethyl)sulfonyl)-2-(2H-tetrazol-5-yl)benzenesulfonamide and 3-(2-aminobenzo[d]thiazol-4-yl)-6-((2-(3-oxomorpholino)ethyl)sulfonyl)-2-(2H-tetrazol-5-yl)benzenesulfonamide::US10227331, Example 258::US10227331, Example 259 Metallo-beta-lactamase type 2 0.469 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368071 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368071&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135150168 402364928 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727138 Nc1nc2c(cccc2s1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)CCN1CCOCC1=O InChI=1S/C20H20N8O6S3/c21-20-23-17-12(2-1-3-13(17)35-20)11-4-5-14(18(37(22,32)33)16(11)19-24-26-27-25-19)36(30,31)9-7-28-6-8-34-10-15(28)29/h1-5H,6-10H2,(H2,21,23)(H2,22,32,33)(H,24,25,26,27) RQRSMBMLWVQUAI-UHFFFAOYSA-N 368071 3-(2-Aminobenzo[d]thiazol-4-yl)-6-((2-morpholinoethyl)sulfonyl)-2-(2H-tetrazol-5-yl)benzenesulfonamide and 3-(2-aminobenzo[d]thiazol-4-yl)-6-((2-(3-oxomorpholino)ethyl)sulfonyl)-2-(2H-tetrazol-5-yl)benzenesulfonamide::US10227331, Example 258::US10227331, Example 259 Metallo-beta-lactamase type 2 0.349 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368071 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368071&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135150168 402364928 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727303 Nc1nc2c(cccc2s1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)CCO InChI=1S/C16H15N7O5S3/c17-16-19-13-9(2-1-3-10(13)29-16)8-4-5-11(30(25,26)7-6-24)14(31(18,27)28)12(8)15-20-22-23-21-15/h1-5,24H,6-7H2,(H2,17,19)(H2,18,27,28)(H,20,21,22,23) QAPUIXGWRVHSIP-UHFFFAOYSA-N 368127 3-(2-aminobenzo[d]thiazol-4-yl)-6-((2-hydroxyethyl)sulfonyl)-2-(2H-tetrazol-5-yl)benzenesulfonamide::US10227331, Example 314 Metallo-beta-lactamase type 2 0.445 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368127 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368127&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 145713727 402364979 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727306 Nc1nc2c(cccc2s1=O)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)C1CCNCC1 368128 3-(2-aminobenzo[d]thiazol-4-yl)-6-(piperidin-4-ylsulfonyl)-2-(2H-tetrazol-5-yl)benzenesulfonamide and 3-(2-amino-1-oxidobenzo[d]thiazol-4-yl)-6-(piperidin-4-ylsulfonyl)-2-(2H-tetrazol-5-yl)benzenesulfonamide::US10227331, Example 315::US10227331, Example 316 Metallo-beta-lactamase type 2 0.249 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368128 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368128&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 140880938 402364980 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727309 Nc1nc2c(cccc2s1=O)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)C1CCNCC1 368128 3-(2-aminobenzo[d]thiazol-4-yl)-6-(piperidin-4-ylsulfonyl)-2-(2H-tetrazol-5-yl)benzenesulfonamide and 3-(2-amino-1-oxidobenzo[d]thiazol-4-yl)-6-(piperidin-4-ylsulfonyl)-2-(2H-tetrazol-5-yl)benzenesulfonamide::US10227331, Example 315::US10227331, Example 316 Metallo-beta-lactamase type 2 0.835 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368128 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368128&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 140880938 402364980 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727312 Nc1nc2c(cccc2s1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)C1CNC1 InChI=1S/C17H16N8O4S3/c18-17-21-14-10(2-1-3-11(14)30-17)9-4-5-12(31(26,27)8-6-20-7-8)15(32(19,28)29)13(9)16-22-24-25-23-16/h1-5,8,20H,6-7H2,(H2,18,21)(H2,19,28,29)(H,22,23,24,25) HVZVQOMJNVRWKJ-UHFFFAOYSA-N 368130 3-(2-aminobenzo[d]thiazol-4-yl)-6-(azetidin-3-ylsulfonyl)-2-(2H-tetrazol-5-yl)benzenesulfonamide::US10227331, Example 317 Metallo-beta-lactamase type 2 0.227 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368130 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368130&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135149717 402364981 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726373 NS(=O)(=O)c1c(SC2CNC2)ccc(-c2ccc(cc2)C2CCNCC2)c1-c1nn[nH]n1 InChI=1S/C21H25N7O2S2/c22-32(29,30)20-18(31-16-11-24-12-16)6-5-17(19(20)21-25-27-28-26-21)15-3-1-13(2-4-15)14-7-9-23-10-8-14/h1-6,14,16,23-24H,7-12H2,(H2,22,29,30)(H,25,26,27,28) VMFSEMKOSSMAGD-UHFFFAOYSA-N 367689 4-(Azetidin-3-ylthio)-4′-(piperidin-4-yl)-2-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-3-sulfonamide::US10227331, Example 4 Metallo-beta-lactamase type 2 15.1 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367689 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367689&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 145713517 402364551 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726376 NS(=O)(=O)c1c(ccc(-c2ccc(cc2)C2CCNCC2)c1-c1nn[nH]n1)S(=O)C1CNC1 367818 4-(Azetidin-3-ylsulfinyl)-4′-(piperidin-4-yl)-2-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-3-sulfonamide::US10227331, Example 5 Metallo-beta-lactamase type 2 6.88 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367818 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367818&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 145713644 402364678 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726379 NS(=O)(=O)c1c(ccc(-c2ccc(cc2)C2CCNCC2)c1-c1nn[nH]n1)S(=O)(=O)C1CNC1 InChI=1S/C21H25N7O4S2/c22-34(31,32)20-18(33(29,30)16-11-24-12-16)6-5-17(19(20)21-25-27-28-26-21)15-3-1-13(2-4-15)14-7-9-23-10-8-14/h1-6,14,16,23-24H,7-12H2,(H2,22,31,32)(H,25,26,27,28) DZZOFVHNQASPFO-UHFFFAOYSA-N 367819 4-(Azetidin-3-ylsulfonyl)-4′-piperidin-4-yl)-2-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-3-sulfonamide::US10227331, Example 6 Metallo-beta-lactamase type 2 0.212 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367819 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367819&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 145713645 402364679 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726382 NS(=O)(=O)c1c(SC2CNC2)ccc(-c2cnc3ccccn23)c1-c1nn[nH]n1 InChI=1S/C17H16N8O2S2/c18-29(26,27)16-13(28-10-7-19-8-10)5-4-11(15(16)17-21-23-24-22-17)12-9-20-14-3-1-2-6-25(12)14/h1-6,9-10,19H,7-8H2,(H2,18,26,27)(H,21,22,23,24) RXUGJNVLQIZYIE-UHFFFAOYSA-N 367820 6-(azetidin-3-ylthio)-3- (imidazo[1,2-a]pyridin-3-yl)- 2-(2H-tetrazol-5- yl)benzenesulfonamide::US10227331, Example 7 Metallo-beta-lactamase type 2 50.4 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367820 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367820&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135149997 402364680 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726385 NS(=O)(=O)c1c(ccc(-c2cnc3ccccn23)c1-c1nn[nH]n1)S(=O)C1CNC1 367821 6-(azetidin-3-ylsulfinyl)-3- (imidazo[1,2-a]pyridin-3-yl)- 2-(2H-tetrazol-5- yl)benzenesulfonamide::US10227331, Example 8 Metallo-beta-lactamase type 2 37.7 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367821 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367821&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135150230 402364681 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726616 NCCS(=O)(=O)c1ccc(-c2cccc3sc(NC(N)=O)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C17H17N9O5S3/c18-6-7-33(28,29)11-5-4-8(12(14(11)34(20,30)31)15-23-25-26-24-15)9-2-1-3-10-13(9)21-17(32-10)22-16(19)27/h1-5H,6-7,18H2,(H2,20,30,31)(H3,19,21,22,27)(H,23,24,25,26) RPTGLYXATYXMIM-UHFFFAOYSA-N 367898 6-(2-aminoethylsulfonyl)-2-(2H-tetrazol-5-yl)-3-(2-ureidobenzo[d]thiazol-4-yl)benzenesulfonamide::US10227331, Example 85 Metallo-beta-lactamase type 2 0.144 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367898 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367898&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124159621 402364758 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726619 NCCS(=O)(=O)c1ccc(-c2cccc3sc(nc23)C(N)=N)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C17H17N9O4S3/c18-6-7-32(27,28)11-5-4-8(12(14(11)33(21,29)30)16-23-25-26-24-16)9-2-1-3-10-13(9)22-17(31-10)15(19)20/h1-5H,6-7,18H2,(H3,19,20)(H2,21,29,30)(H,23,24,25,26) VLHWEFRARRJBNF-UHFFFAOYSA-N 367899 4-(4-(2-aminoethyl sulfonyl)-3-sulfamoyl-2-(2H-tetrazol-5-yl)phenyl)benzo[d]thiazole-2-carboximidamide::US10227331, Example 86 Metallo-beta-lactamase type 2 0.869 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367899 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367899&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124157268 402364759 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726622 NCCS(=O)(=O)c1ccc(-c2cccc3sc(CN)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C17H18N8O4S3/c18-6-7-31(26,27)12-5-4-9(10-2-1-3-11-15(10)21-13(8-19)30-11)14(16(12)32(20,28)29)17-22-24-25-23-17/h1-5H,6-8,18-19H2,(H2,20,28,29)(H,22,23,24,25) XIVDDYZTSWPWTF-UHFFFAOYSA-N 367900 6-(2-aminoethylsulfonyl)-3-(2-(aminomethyl)benzo[d]thiazol-4-yl)-2-(2H-tetrazol-5-yl)benzenesulfonamide::US10227331, Example 87 Metallo-beta-lactamase type 2 0.562 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367900 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367900&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124157505 402364760 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726625 NCCS(=O)(=O)c1ccc(-c2cccc3sc(nc23)C(O)=O)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C17H15N7O6S3/c18-6-7-32(27,28)11-5-4-8(12(14(11)33(19,29)30)15-21-23-24-22-15)9-2-1-3-10-13(9)20-16(31-10)17(25)26/h1-5H,6-7,18H2,(H,25,26)(H2,19,29,30)(H,21,22,23,24) AHTXJNLBDXSMQQ-UHFFFAOYSA-N 367901 4-(4-(2-aminoethylsulfonyl)-3-sulfamoyl-2-(2H-tetrazol-5-yl)phenyl)benzo[d]thiazole-2-carboxylic acid::US10227331, Example 88 Metallo-beta-lactamase type 2 0.144 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367901 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367901&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124157581 402364761 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726766 CC(=O)Nc1ccc(cn1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)CCN InChI=1S/C16H18N8O5S2/c1-9(25)20-13-5-2-10(8-19-13)11-3-4-12(30(26,27)7-6-17)15(31(18,28)29)14(11)16-21-23-24-22-16/h2-5,8H,6-7,17H2,1H3,(H2,18,28,29)(H,19,20,25)(H,21,22,23,24) ATIOOXXSVFRWSN-UHFFFAOYSA-N 367948 2-((4-(6- acetamidopyridin-3-yl)- 2-sulfamoyl-3-(1H- tetrazol-5- yl)phenyl)sulfonyl) ethanaminium 2,2,2- trifluoroacetate::US10227331, Example 135 Metallo-beta-lactamase type 2 1.65 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367948 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367948&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135149693 402364808 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726769 NCCS(=O)(=O)c1ccc(-c2c[nH]c3nccnc23)c(-c2nnn[nH]2)c1S(N)(=O)=O InChI=1S/C15H15N9O4S2/c16-3-6-29(25,26)10-2-1-8(9-7-20-15-12(9)18-4-5-19-15)11(13(10)30(17,27)28)14-21-23-24-22-14/h1-2,4-5,7H,3,6,16H2,(H,19,20)(H2,17,27,28)(H,21,22,23,24) MLLGRZJJABTFMI-UHFFFAOYSA-N 367949 2-((4-(5H-pyrrolo[2,3- b]pyrazin-7-yl)-2- sulfamoyl-3-(1H- tetrazol-5- yl)phenyl)sulfonyl) ethanaminium 2,2,2- trifluoroacetate::US10227331, Example 136 Metallo-beta-lactamase type 2 1.71 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367949 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367949&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 145713683 402364809 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726772 NCCS(=O)(=O)c1ccc(-c2cnc(O)nc2)c(-c2nnn[nH]2)c1S(N)(=O)=O InChI=1S/C13H14N8O5S2/c14-3-4-27(23,24)9-2-1-8(7-5-16-13(22)17-6-7)10(11(9)28(15,25)26)12-18-20-21-19-12/h1-2,5-6H,3-4,14H2,(H2,15,25,26)(H,16,17,22)(H,18,19,20,21) YLIGEJLHNJVTNH-UHFFFAOYSA-N 367950 2-((4-(2- hydroxypyrimidin-5-yl)- 2-sulfamoyl-3-(1H- tetrazol-5- yl)phenyl)sulfonyl) ethanaminium 2,2,2- trifluoroacetate::US10227331, Example 137 Metallo-beta-lactamase type 2 32.6 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367950 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367950&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135149948 402364810 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726775 NCCS(=O)(=O)c1ccc(-c2ccnc3ccccc23)c(-c2nnn[nH]2)c1S(N)(=O)=O InChI=1S/C18H17N7O4S2/c19-8-10-30(26,27)15-6-5-13(11-7-9-21-14-4-2-1-3-12(11)14)16(17(15)31(20,28)29)18-22-24-25-23-18/h1-7,9H,8,10,19H2,(H2,20,28,29)(H,22,23,24,25) WPIRTJLZZPKKEN-UHFFFAOYSA-N 367951 2-((4-(quinolin-4-yl)-2- sulfamoyl-3-(1H- tetrazol-5- yl)phenyl)sulfonyl) ethanaminium 2,2,2- trifluoroacetate::US10227331, Example 138 Metallo-beta-lactamase type 2 1.28 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367951 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367951&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135149581 402364811 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726778 CNC(=O)c1ccc(cn1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)CCN InChI=1S/C16H18N8O5S2/c1-19-16(25)11-4-2-9(8-20-11)10-3-5-12(30(26,27)7-6-17)14(31(18,28)29)13(10)15-21-23-24-22-15/h2-5,8H,6-7,17H2,1H3,(H,19,25)(H2,18,28,29)(H,21,22,23,24) CTRVOYZZYFJLCL-UHFFFAOYSA-N 367952 2-((4-(6- (methylcarbamoyl)pyridin- 3-yl)-2-sulfamoyl-3- (1H-tetrazol-5- yl)phenyl)sulfonyl) ethanaminium 2,2,2- trifluoroacetate::US10227331, Example 139 Metallo-beta-lactamase type 2 3.32 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367952 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367952&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135150147 402364812 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726820 Cn1cc2cc(ccc2n1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)CCN InChI=1S/C17H18N8O4S2/c1-25-9-11-8-10(2-4-13(11)22-25)12-3-5-14(30(26,27)7-6-18)16(31(19,28)29)15(12)17-20-23-24-21-17/h2-5,8-9H,6-7,18H2,1H3,(H2,19,28,29)(H,20,21,23,24) YJYYLSDAPWZJRO-UHFFFAOYSA-N 367966 2-((4-(2-methyl-2H- indazol-5-yl)-2- sulfamoyl-3-(1H- tetrazol-5- yl)phenyl)sulfonyl) ethanaminium 2,2,2- trifluoroacetate::US10227331, Example 153 Metallo-beta-lactamase type 2 0.457 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367966 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367966&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135150237 402364826 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726823 Cn1cc2ccc(cc2n1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)CCN InChI=1S/C17H18N8O4S2/c1-25-9-11-3-2-10(8-13(11)22-25)12-4-5-14(30(26,27)7-6-18)16(31(19,28)29)15(12)17-20-23-24-21-17/h2-5,8-9H,6-7,18H2,1H3,(H2,19,28,29)(H,20,21,23,24) ZIFQODQZYPESOE-UHFFFAOYSA-N 367967 2-((4-(2-methyl-2H- indazol-6-yl)-2- sulfamoyl-3-(1H- tetrazol-5- yl)phenyl)sulfonyl) ethanaminium 2,2,2- trifluoroacetate::US10227331, Example 154 Metallo-beta-lactamase type 2 0.676 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367967 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367967&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135149756 402364827 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726826 NCCS(=O)(=O)c1ccc(-c2ccc3[nH]c(=O)oc3c2)c(-c2nnn[nH]2)c1S(N)(=O)=O InChI=1S/C16H15N7O6S2/c17-5-6-30(25,26)12-4-2-9(8-1-3-10-11(7-8)29-16(24)19-10)13(14(12)31(18,27)28)15-20-22-23-21-15/h1-4,7H,5-6,17H2,(H,19,24)(H2,18,27,28)(H,20,21,22,23) MTRXZAYDTGTVKL-UHFFFAOYSA-N 367968 2-((4-(2-oxo-2,3- dihydrobenzo[d]oxazol- 6-yl)-2-sulfamoyl-3- (1H-tetrazol-5- yl)phenyl)sulfonyl) ethanaminium 2,2,2- trifluoroacetate::US10227331, Example 155 Metallo-beta-lactamase type 2 0.226 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367968 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367968&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135150221 402364828 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726829 NCCS(=O)(=O)c1ccc(-c2cccc(c2)-n2cccn2)c(-c2nnn[nH]2)c1S(N)(=O)=O InChI=1S/C18H18N8O4S2/c19-7-10-31(27,28)15-6-5-14(12-3-1-4-13(11-12)26-9-2-8-21-26)16(17(15)32(20,29)30)18-22-24-25-23-18/h1-6,8-9,11H,7,10,19H2,(H2,20,29,30)(H,22,23,24,25) HOJKIFJSILSXOV-UHFFFAOYSA-N 367969 2-((3'-(1H-pyrazol-1- yl)-3-sulfamoyl-2-(1H- tetrazol-5-yl)-[1,1'- biphenyl]-4- yl)sulfonyl) ethanaminium 2,2,2- trifluoroacetate::US10227331, Example 156 Metallo-beta-lactamase type 2 0.981 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367969 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367969&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135150108 402364829 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727141 Nc1nc2cc(cc(-c3ccc(c(c3-c3nnn[nH]3)S(N)(=O)=O)S(=O)(=O)C3CNC3)c2[nH]1)C(F)(F)F InChI=1S/C18H16F3N9O4S2/c19-18(20,21)7-3-10(14-11(4-7)25-17(22)26-14)9-1-2-12(35(31,32)8-5-24-6-8)15(36(23,33)34)13(9)16-27-29-30-28-16/h1-4,8,24H,5-6H2,(H3,22,25,26)(H2,23,33,34)(H,27,28,29,30) JSEISUUEPZFXFD-UHFFFAOYSA-N 368073 3-(2-amino-5-(trifluoromethyl)-1H-benzo[d]imidazol-7-yl)-6-(azetidin-3-ylsulfonyl)-2-(1H-tetrazol-5-yl)benzenesulfonamide::US10227331, Example 260 Metallo-beta-lactamase type 2 1.99 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368073 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368073&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124159633 402364929 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727144 Nc1nc2cc(cc(-c3ccc(c(c3-c3nnn[nH]3)S(N)(=O)=O)S(=O)(=O)C3CNC3)c2[nH]1)C#N InChI=1S/C18H16N10O4S2/c19-5-8-3-11(15-12(4-8)23-18(20)24-15)10-1-2-13(33(29,30)9-6-22-7-9)16(34(21,31)32)14(10)17-25-27-28-26-17/h1-4,9,22H,6-7H2,(H3,20,23,24)(H2,21,31,32)(H,25,26,27,28) FNMWXZZNCCEOIN-UHFFFAOYSA-N 368074 3-(2-amino-5-cyano-1H- benzo[d]imidazol-7-yl)-6- (azetidin-3-ylsulfonyl)-2- (1H-tetrazol-5-yl) benzenesulfonamide::US10227331, Example 261 Metallo-beta-lactamase type 2 1.15 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368074 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368074&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135149826 402364930 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727147 Nc1nc2cc(F)cc(-c3ccc(c(c3-c3nnn[nH]3)S(N)(=O)=O)S(=O)(=O)C3CNC3)c2[nH]1 InChI=1S/C17H16FN9O4S2/c18-7-3-10(14-11(4-7)22-17(19)23-14)9-1-2-12(32(28,29)8-5-21-6-8)15(33(20,30)31)13(9)16-24-26-27-25-16/h1-4,8,21H,5-6H2,(H3,19,22,23)(H2,20,30,31)(H,24,25,26,27) DXOQIYNMGZMNIU-UHFFFAOYSA-N 368075 3-(2-amino-5-fluoro-1H- benzo[d]imidazol-7-yl)-6- (azetidin-3-ylsulfonyl)-2- (1H-tetrazol-5-yl) benzenesulfonamide::US10227331, Example 262::US10227331, Example 296 Metallo-beta-lactamase type 2 0.506 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368075 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368075&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135149657 402364931 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727150 Nc1n[nH]c2cccc(-c3ccc(c(c3-c3nnn[nH]3)S(N)(=O)=O)S(=O)(=O)C3CNC3)c12 InChI=1S/C17H17N9O4S2/c18-16-13-9(2-1-3-11(13)21-22-16)10-4-5-12(31(27,28)8-6-20-7-8)15(32(19,29)30)14(10)17-23-25-26-24-17/h1-5,8,20H,6-7H2,(H3,18,21,22)(H2,19,29,30)(H,23,24,25,26) SLGGGJUNPHLXKA-UHFFFAOYSA-N 368076 3-(3-amino-1H-indazol-4- yl)-6-(azetidin-3-ylsulfonyl)- 2-(1H-tetrazol-5-yl) benzenesulfonamide::US10227331, Example 263 Metallo-beta-lactamase type 2 4.59 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368076 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368076&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135149551 402364932 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727315 NS(=O)(=O)c1c(ccc(-c2cccc3C(=O)NCc23)c1-c1nn[nH]n1)S(=O)(=O)C1CCNCC1 InChI=1S/C20H21N7O5S2/c21-34(31,32)18-16(33(29,30)11-6-8-22-9-7-11)5-4-13(17(18)19-24-26-27-25-19)12-2-1-3-14-15(12)10-23-20(14)28/h1-5,11,22H,6-10H2,(H,23,28)(H2,21,31,32)(H,24,25,26,27) IUNMLNRITLNFSZ-UHFFFAOYSA-N 368131 3-(1-oxoisoindolin-4-yl)-6-(piperidin-4-ylsulfonyl)-2-(2H-tetrazol-5-yl)benzenesulfonamide::US10227331, Example 318 Metallo-beta-lactamase type 2 27.1 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368131 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368131&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124157566 402364982 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727318 Nc1nc2c(cccc2c[n+]1[O-])-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)CCO InChI=1S/C17H16N8O6S2/c18-17-20-14-9(8-25(17)27)2-1-3-11(14)10-4-5-12(32(28,29)7-6-26)15(33(19,30)31)13(10)16-21-23-24-22-16/h1-5,8,26H,6-7H2,(H2,18,20)(H2,19,30,31)(H,21,22,23,24) SILDHLDMNLRDJA-UHFFFAOYSA-N 368132 2-amino-8-(4-((2-hydroxyethyl)sulfonyl)-3-sulfamoyl-2-(2H-tetrazol-5-yl)phenyl)quinazoline 3-oxide::US10227331, Example 319 Metallo-beta-lactamase type 2 1.92 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368132 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368132&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 145713728 402364983 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727321 NS(=O)(=O)c1c(ccc(-c2cccc3[n+]([O-])cccc23)c1-c1nn[nH]n1)S(=O)(=O)CCO InChI=1S/C18H16N6O6S2/c19-32(29,30)17-15(31(27,28)10-9-25)7-6-13(16(17)18-20-22-23-21-18)11-3-1-5-14-12(11)4-2-8-24(14)26/h1-8,25H,9-10H2,(H2,19,29,30)(H,20,21,22,23) UWXLXZRRZDDOIZ-UHFFFAOYSA-N 368133 5-(4-((2-hydroxyethyl)sulfonyl)-3-sulfamoyl-2-(2H-tetrazol-5-yl)phenyl)quinoline 1-oxide::US10227331, Example 320 Metallo-beta-lactamase type 2 1.06 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368133 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368133&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 145713729 402364984 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727324 NCCS(=O)(=O)c1ccc(-c2ccc(N)nc2)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C14H16N8O4S2/c15-5-6-27(23,24)10-3-2-9(8-1-4-11(16)18-7-8)12(13(10)28(17,25)26)14-19-21-22-20-14/h1-4,7H,5-6,15H2,(H2,16,18)(H2,17,25,26)(H,19,20,21,22) ZZTQEPNLUZOBOF-UHFFFAOYSA-N 368134 6-((2-aminoethyl)sulfonyl)-3- (6-aminopyridin-3-yl)-2-(2H- tetrazol-5-yl) benzenesulfonamide::US10227331, Example 321 Metallo-beta-lactamase type 2 0.949 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368134 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368134&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 145713730 402364985 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727387 NCCNC(=O)c1ccccc1-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)CCN InChI=1S/C18H22N8O5S2/c19-7-9-22-18(27)13-4-2-1-3-11(13)12-5-6-14(32(28,29)10-8-20)16(33(21,30)31)15(12)17-23-25-26-24-17/h1-6H,7-10,19-20H2,(H,22,27)(H2,21,30,31)(H,23,24,25,26) FQGXUOZQHXDCAA-UHFFFAOYSA-N 368155 N-(2-Aminoethyl)-4′-((2-aminoethyl)sulfonyl)-3′-sulfamoyl-2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-2-carboxamide::US10227331, Example 342 Metallo-beta-lactamase type 2 34.2 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368155 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368155&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 145713748 402365005 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727390 NS(=O)(=O)c1c(ccc(-c2ccnc(c2)N2CCNC2=O)c1-c1nnn[nH]1)S(=O)(=O)C1CNC1 InChI=1S/C18H19N9O5S2/c19-34(31,32)16-13(33(29,30)11-8-20-9-11)2-1-12(15(16)17-23-25-26-24-17)10-3-4-21-14(7-10)27-6-5-22-18(27)28/h1-4,7,11,20H,5-6,8-9H2,(H,22,28)(H2,19,31,32)(H,23,24,25,26) RBSVDYXFVIRUKK-UHFFFAOYSA-N 368156 6-(Azetidin-3-ylsulfonyl)-3-(2-(2-oxoimidazolidin-1-yl)pyridin-4-yl)-2-(1H-tetrazol-5-yl)benzenesulfonamide::US10227331, Example 343 Metallo-beta-lactamase type 2 1.89 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368156 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368156&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 145713749 402365006 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727393 Nc1nnc(o1)-c1cccc(c1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)C1CNC1 InChI=1S/C18H17N9O5S2/c19-18-25-24-17(32-18)10-3-1-2-9(6-10)12-4-5-13(33(28,29)11-7-21-8-11)15(34(20,30)31)14(12)16-22-26-27-23-16/h1-6,11,21H,7-8H2,(H2,19,25)(H2,20,30,31)(H,22,23,26,27) GMGRDUUOLCNRHO-UHFFFAOYSA-N 368157 3′-(5-Amino-1,3,4-oxadiazol-2-yl)-4-(azetidin-3-ylsulfonyl)-2-(1H-tetrazol-5-yl)-[1,1′-biphenyl]-3-sulfonamide::US10227331, Example 344 Metallo-beta-lactamase type 2 1.70 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368157 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368157&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 145713750 402365007 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727396 NCCS(=O)(=O)c1ccc(-c2cccc(c2)-n2ccnc2)c(-c2nnn[nH]2)c1S(N)(=O)=O InChI=1S/C18H18N8O4S2/c19-6-9-31(27,28)15-5-4-14(12-2-1-3-13(10-12)26-8-7-21-11-26)16(17(15)32(20,29)30)18-22-24-25-23-18/h1-5,7-8,10-11H,6,9,19H2,(H2,20,29,30)(H,22,23,24,25) GGWWDTOYSZNAAM-UHFFFAOYSA-N 368158 4-((2-Aminoethyl)sulfonyl)-3′-(1H-imidazol-1-yl)-2-(1H-tetrazol-5-yl)-[1,1′-biphenyl]-3-sulfonamide::US10227331, Example 345 Metallo-beta-lactamase type 2 0.857 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368158 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368158&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 145713751 402365008 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726388 NS(=O)(=O)c1c(ccc(-c2cnc3ccccn23)c1-c1nn[nH]n1)S(=O)(=O)C1CNC1 InChI=1S/C17H16N8O4S2/c18-31(28,29)16-13(30(26,27)10-7-19-8-10)5-4-11(15(16)17-21-23-24-22-17)12-9-20-14-3-1-2-6-25(12)14/h1-6,9-10,19H,7-8H2,(H2,18,28,29)(H,21,22,23,24) APZLRISPJJBTHB-UHFFFAOYSA-N 367822 6-(Azetidin-3-ylsulfonyl)-3-(imidazo[1,2-a]pyridin-3-yl)-2-(2H-tetrazol-5-yl)benzenesulfonamide::US10227331, Example 9 Metallo-beta-lactamase type 2 0.913 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367822 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367822&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124157345 402364682 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726391 Nc1ccc(cn1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)C1CCNCC1 367823 3-(6-aminopyridin-3-yl)-6-(piperidin-4-ylsulfinyl)-2-(2H-tetrazol-5-yl)benzenesulfonamide::US10227331, Example 10 Metallo-beta-lactamase type 2 27.3 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367823 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367823&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 145866011 402364683 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726394 Nc1nc2cc(ccc2[nH]1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)C1CNC1 InChI=1S/C17H15N9O3S2/c18-17-21-11-3-1-8(5-12(11)22-17)10-2-4-13(30(27)9-6-20-7-9)15(31(19,28)29)14(10)16-23-25-26-24-16/h1-5,9,20H,6-7H2,(H2,18,22)(H2,19,28,29)/b10-8+ YXZZBXLGWVKHAA-CSKARUKUSA-N 367824 3-(2-amino-1H-benzo[d]imidazol-5-yl)-6-(azetidin-3-ylsulfinyl)-2-(2H-tetrazol-5-yl)benzenesulfonamide::US10227331, Example 11 Metallo-beta-lactamase type 2 41.3 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367824 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367824&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 145713646 402364684 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726397 Nc1nc2ccc(cc2[nH]1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)C1CCNCC1 InChI=1S/C19H19N9O3S2/c20-19-23-13-3-1-10(9-14(13)24-19)12-2-4-15(32(29)11-5-7-22-8-6-11)17(33(21,30)31)16(12)18-25-27-28-26-18/h1-4,9,11,22H,5-8H2,(H2,20,24)(H2,21,30,31)/b12-10+ MTTMBVITUCQZDG-ZRDIBKRKSA-N 367825 3-(2-amino-3H-benzo[d]imidazol-5-yl)-6-(piperidin-4-ylsulfinyl)-2-(2H-tetrazol-5-yl)benzenesulfonamide::US10227331, Example 12 Metallo-beta-lactamase type 2 130 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367825 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367825&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 145713647 402364685 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726400 Nc1nc2c(cccc2[nH]1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)C1CNC1 InChI=1S/C17H15N9O3S2/c18-17-21-11-3-1-2-10(14(11)22-17)9-4-5-12(30(27)8-6-20-7-8)15(31(19,28)29)13(9)16-23-25-26-24-16/h1-5,8,20H,6-7H2,(H2,18,21)(H2,19,28,29)/b10-9+ DIIFSMJMLDGHLE-MDZDMXLPSA-N 367826 3-(2-amino-1H-benzo[d]imidazol-4-yl)-6-(azetidin-3-ylsulfinyl)-2-(2H-tetrazol-5-yl)benzenesulfonamide::US10227331, Example 13 Metallo-beta-lactamase type 2 50.8 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367826 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367826&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 145713648 402364686 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726628 NCCS(=O)(=O)c1ccc(-c2cccc3sc(nc23)C(N)=O)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C17H16N8O5S3/c18-6-7-32(27,28)11-5-4-8(12(14(11)33(20,29)30)16-22-24-25-23-16)9-2-1-3-10-13(9)21-17(31-10)15(19)26/h1-5H,6-7,18H2,(H2,19,26)(H2,20,29,30)(H,22,23,24,25) KQKGDJGEBYLFRO-UHFFFAOYSA-N 367902 4-(4-(2-aminoethyl sulfonyl)-3-sulfamoyl-2-(2H-tetrazol-5-yl)phenyl)benzo[d]thiazole-2-carboxamide::US10227331, Example 89 Metallo-beta-lactamase type 2 0.601 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367902 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367902&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124159640 402364762 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726631 CNc1nc2c(cccc2s1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)CCN InChI=1S/C17H18N8O4S3/c1-20-17-21-14-10(3-2-4-11(14)30-17)9-5-6-12(31(26,27)8-7-18)15(32(19,28)29)13(9)16-22-24-25-23-16/h2-6H,7-8,18H2,1H3,(H,20,21)(H2,19,28,29)(H,22,23,24,25) NSGMUFSUDIXAJY-UHFFFAOYSA-N 367903 6-(2-aminoethylsulfonyl)-3-(2-(methylamino)benzo[d]thiazol-4-yl)-2-(2H-tetrazol-5-yl)benzene sulfonamide::US10227331, Example 90 Metallo-beta-lactamase type 2 0.099 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367903 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367903&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124157229 402364763 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726634 NCCS(=O)(=O)c1ccc(-c2cccc3[nH]c(nc23)C(O)=O)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C17H16N8O6S2/c18-6-7-32(28,29)11-5-4-8(12(14(11)33(19,30)31)15-22-24-25-23-15)9-2-1-3-10-13(9)21-16(20-10)17(26)27/h1-5H,6-7,18H2,(H,20,21)(H,26,27)(H2,19,30,31)(H,22,23,24,25) XMVHEOUQQVALRW-UHFFFAOYSA-N 367904 4-(4-((2-aminoethyl)sulfonyl)-3-sulfamoyl-2-(2H-tetrazol-5-yl)phenyl)-1H-benzo[d]imidazole-2-carboxylic Acid::US10227331, Example 91 Metallo-beta-lactamase type 2 0.386 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367904 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367904&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124159604 402364764 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726637 C[C@H](N)CS(=O)(=O)c1ccc(-c2cccc3[nH]c(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C17H17N9O4S2/c1-8(18)7-31(27,28)12-6-5-9(10-3-2-4-11-14(10)22-17(19)21-11)13(15(12)32(20,29)30)16-23-25-26-24-16/h2-6,8H,7,18H2,1H3,(H2,19,21)(H2,20,29,30)/b10-9+/t8-/m0/s1 MMRBNGMXQXYJTP-VPOJCXOPSA-N 367905 3-(2-amino-1H-benzo[d]imidazol-4-yl)-6-((S)-2-aminopropylsulfonyl)-2-(2H-tetrazol-5-yl)benzenesulfonamide::US10227331, Example 92 Metallo-beta-lactamase type 2 0.612 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367905 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367905&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124159641 402364765 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726640 C[C@H](N)CS(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O 367906 3-(2-aminobenzo[d]thiazol-4-yl)-6-((S)-2-aminopropylsulfonyl)-2-(2H-tetrazol-5-yl)benzenesulfonamide::US10227331, Example 93 Metallo-beta-lactamase type 2 0.130 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367906 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367906&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124159624 402364766 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726832 NCCS(=O)(=O)c1ccc(-c2ccc3NC(=O)Cc3c2)c(-c2nnn[nH]2)c1S(N)(=O)=O InChI=1S/C17H17N7O5S2/c18-5-6-30(26,27)13-4-2-11(9-1-3-12-10(7-9)8-14(25)20-12)15(16(13)31(19,28)29)17-21-23-24-22-17/h1-4,7H,5-6,8,18H2,(H,20,25)(H2,19,28,29)(H,21,22,23,24) FDSAINKFLXYIHO-UHFFFAOYSA-N 367970 2-((4-(2-oxoindolin-5- yl)-2-sulfamoyl-3-(1H- tetrazol-5- yl)phenyl)sulfonyl) ethanaminium 2,2,2- trifluoroacetate::US10227331, Example 157 Metallo-beta-lactamase type 2 1.89 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367970 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367970&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135150157 402364830 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726835 NCCS(=O)(=O)c1ccc(-c2cccc(c2)N2CCS(=O)(=O)CC2)c(-c2nnn[nH]2)c1S(N)(=O)=O InChI=1S/C19H23N7O6S3/c20-6-9-34(29,30)16-5-4-15(17(18(16)35(21,31)32)19-22-24-25-23-19)13-2-1-3-14(12-13)26-7-10-33(27,28)11-8-26/h1-5,12H,6-11,20H2,(H2,21,31,32)(H,22,23,24,25) GFAQXUVHFQBZJV-UHFFFAOYSA-N 367971 2-((3'-(1,1- dioxidothiomorpholino)- 3-sulfamoyl-2-(1H- tetrazol-5-yl)-[1,1'- biphenyl]-4- yl)sulfonyl) ethanaminium 2,2,2- trifluoroacetate::US10227331, Example 158 Metallo-beta-lactamase type 2 6.27 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367971 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367971&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135149787 402364831 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 726838 NCCS(=O)(=O)c1ccc(-c2ccc3cccnc3c2)c(-c2nnn[nH]2)c1S(N)(=O)=O InChI=1S/C18H17N7O4S2/c19-7-9-30(26,27)15-6-5-13(12-4-3-11-2-1-8-21-14(11)10-12)16(17(15)31(20,28)29)18-22-24-25-23-18/h1-6,8,10H,7,9,19H2,(H2,20,28,29)(H,22,23,24,25) JDMGZCCCWINWRB-UHFFFAOYSA-N 367972 2-((4-(quinolin-7-yl)-2- sulfamoyl-3-(1H- tetrazol-5- yl)phenyl)sulfonyl) ethanaminium 2,2,2- trifluoroacetate::US10227331, Example 159 Metallo-beta-lactamase type 2 0.487 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367972 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367972&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135149539 402364832 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713185 Nc1nc2c(cccc2s1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)NC1CN2CCC1CC2 360941 3-(4-(2-amino- benzo[d]thiazol- 4-yl)-2-sulfamoyl-3- (1H-tetrazol-5-yl) phenylsulfonamido) quinuclidin- 1-ium 2,2,2- trifluoroacetate::US10221163, Example 97::US10544130, Example 97 Metallo-beta-lactamase type 2 0.383 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360941 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360941&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135310915 386400331 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713188 N[C@H]1C[C@@H](C1)NS(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nnn[nH]2)c1S(N)(=O)=O 360942 (1r,3r)-3-(4-(2- aminobenzo[d] thiazol-4-yl)-2- sulfamoyl-3- (1H-tetrazol-5-yl) phenylsulfonamido) cyclobutanaminium 2,2,2- trifluoroacetate::US10221163, Example 98 Metallo-beta-lactamase type 2 0.209 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360942 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360942&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311334 386400332 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713191 N[C@H](NS(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nnn[nH]2)c1S(N)(=O)=O)c1ccccn1 360943 (R)-(4-(2- aminobenzo [d]thiazol-4-yl)-2- sulfamoyl-3-(1H- tetrazol-5-yl) phenylsulfonamido) (pyridin-2-yl) methanaminium 2,2,2- trifluoroacetate::US10221163, Example 99::US10544130, Example 99 Metallo-beta-lactamase type 2 0.566 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360943 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360943&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269199 386400333 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713194 CN(CCc1ccncc1)S(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nnn[nH]2)c1S(N)(=O)=O InChI=1S/C22H21N9O4S3/c1-31(12-9-13-7-10-25-11-8-13)38(34,35)17-6-5-14(15-3-2-4-16-19(15)26-22(23)36-16)18(20(17)37(24,32)33)21-27-29-30-28-21/h2-8,10-11H,9,12H2,1H3,(H2,23,26)(H2,24,32,33)(H,27,28,29,30) UMNPTGPXWSXOOY-UHFFFAOYSA-N 360944 4-(2-(4-(2- aminobenzo[d] thiazol-4-yl)-N- methyl-2-sulfamoyl- 3-(1H-tetrazol-5- yl)phenyl- sulfonamido) ethyl)pyridin- 1-ium 2,2,2- trifluoroacetate::US10221163, Example 100::US10544130, Example 100 Metallo-beta-lactamase type 2 3.26 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360944 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360944&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269200 386400334 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713197 CC1(CN)CN(C1)S(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nnn[nH]2)c1S(N)(=O)=O InChI=1S/C19H21N9O4S3/c1-19(7-20)8-28(9-19)35(31,32)13-6-5-10(11-3-2-4-12-15(11)23-18(21)33-12)14(16(13)34(22,29)30)17-24-26-27-25-17/h2-6H,7-9,20H2,1H3,(H2,21,23)(H2,22,29,30)(H,24,25,26,27) ZWPMTWURJWGRPP-UHFFFAOYSA-N 360945 (1-((4-(2- aminobenzo [d]thiazol-4-yl)-2- sulfamoyl-3-(1H- tetrazol-5-yl)phenyl) sulfonyl)-3- methylazetidin- 3-yl) methanaminium 2,2,2- trifluoroacetate::US10221163, Example 101::US10544130, Example 101 Metallo-beta-lactamase type 2 1.25 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360945 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360945&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311100 386400335 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713200 CN1CCC(CNS(=O)(=O)c2ccc(-c3cccc4sc(N)nc34)c(-c3nnn[nH]3)c2S(N)(=O)=O)C1 360946 3-((4-(2- aminobenzo [d]thiazol-4-yl)-2- sulfamoyl-3- (1H-tetrazol-5-yl) phenylsulfonamido) methyl)-1- methylpyrrolidin- 1-ium 2,2,2- trifluoroacetate::US10221163, Example 102::US10544130, Example 102 Metallo-beta-lactamase type 2 0.263 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360946 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360946&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311988 386400336 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713203 N[C@@H]1CO[C@@H]2[C@H](CO[C@H]12)NS(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nnn[nH]2)c1S(N)(=O)=O 360947 (3R,3aR, 6S,6aR)-6-(4-(2- aminobenzo[d] thiazol-4-yl)-2- sulfamoyl-3-(1H- tetrazol-5-yl)phenyl- sulfonamido) hexahydrofuro[3,2- b]furan-3-aminium 2,2,2- trifluoroacetate::US10221163, Example 103::US10544130, Example 103 Metallo-beta-lactamase type 2 0.226 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360947 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360947&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 137537510 386400337 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713206 NCC1CN(CCO1)S(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nnn[nH]2)c1S(N)(=O)=O 360948 (4-((4-(2- aminobenzo[d] thiazol-4-yl)-2- sulfamoyl-3- (1H-tetrazol-5-yl) phenyl)sulfonyl) morpholin-2-yl) methanaminium 2,2,2- trifluoroacetate::US10221163, Example 104::US10544130, Example 104 Metallo-beta-lactamase type 2 1.24 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360948 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360948&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135310981 386400338 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713209 CN(C1CNC1)S(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nnn[nH]2)c1S(N)(=O)=O InChI=1S/C18H19N9O4S3/c1-27(9-7-21-8-9)34(30,31)13-6-5-10(11-3-2-4-12-15(11)22-18(19)32-12)14(16(13)33(20,28)29)17-23-25-26-24-17/h2-6,9,21H,7-8H2,1H3,(H2,19,22)(H2,20,28,29)(H,23,24,25,26) AYUSQLJTKXUKDZ-UHFFFAOYSA-N 360949 3-(4-(2- aminobenzo[d] thiazol-4-yl)-N- methyl-2-sulfamoyl- 3-(1H-tetrazol-5-yl) phenylsulfonamido) azetidin-1-ium 2,2,2- trifluoroacetate::US10221163, Example 105::US10544130, Example 105 Metallo-beta-lactamase type 2 1.18 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360949 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360949&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311037 386400339 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713212 Nc1nc2c(cccc2s1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)NCc1ccccn1 InChI=1S/C20H17N9O4S3/c21-20-25-17-13(5-3-6-14(17)34-20)12-7-8-15(36(32,33)24-10-11-4-1-2-9-23-11)18(35(22,30)31)16(12)19-26-28-29-27-19/h1-9,24H,10H2,(H2,21,25)(H2,22,30,31)(H,26,27,28,29) CUZJLQPCENXUCT-UHFFFAOYSA-N 360950 2-((4-(2- aminobenzo [d]thiazol-4-yl)- 2-sulfamoyl-3- (1H-tetrazol-5-yl) phenylsulfonamido) methyl)pyridin-1-ium 2,2,2- trifluoroacetate::US10221163, Example 106::US10544130, Example 106 Metallo-beta-lactamase type 2 0.379 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360950 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360950&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269201 386400340 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713215 CN(C1CN(C)C1)S(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nnn[nH]2)c1S(N)(=O)=O InChI=1S/C19H21N9O4S3/c1-27-8-10(9-27)28(2)35(31,32)14-7-6-11(12-4-3-5-13-16(12)22-19(20)33-13)15(17(14)34(21,29)30)18-23-25-26-24-18/h3-7,10H,8-9H2,1-2H3,(H2,20,22)(H2,21,29,30)(H,23,24,25,26) VEXYMHUJQMBNMQ-UHFFFAOYSA-N 360951 3-(4-(2- aminobenzo [d]thiazol-4-yl)-N- methyl-2-sulfamoyl- 3-(1H-tetrazol-5-yl) phenylsulfonamido)- 1-methylazetidin- 1-ium 2,2,2- trifluoroacetate::US10221163, Example 107::US10544130, Example 107 Metallo-beta-lactamase type 2 1.40 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360951 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360951&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311515 386400341 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713218 CO[C@H]1CNC[C@@H]1NS(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nnn[nH]2)c1S(N)(=O)=O 360952 (3S,4S)-3-(4-(2- aminobenzo[d] thiazol-4-yl)-2- sulfamoyl-3- (1H-tetrazol-5-yl) phenylsulfonamido)- 4-methoxypyrrolidin- 1-ium 2,2,2- trifluoroacetate::US10221163, Example 108::US10544130, Example 108 Metallo-beta-lactamase type 2 0.336 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360952 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360952&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311185 386400342 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713221 CC(N)CNS(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nnn[nH]2)c1S(N)(=O)=O 360953 1-(4-(2- aminobenzo[d] thiazol-4-yl)-2- sulfamoyl-3-(1H- tetrazol-5-yl)phenyl- sulfonamido) propan-2-aminium 2,2,2- trifluoroacetate::US10221163, Example 109::US10544130, Example 109 Metallo-beta-lactamase type 2 0.440 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360953 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360953&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135310971 386400343 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713224 NCC1CCCCN1S(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nnn[nH]2)c1S(N)(=O)=O 360954 (1-((4-(2- aminobenzo[d] thiazol-4-yl)-2- sulfamoyl-3-(1H- tetrazol-5-yl)phenyl) sulfonyl)piperidin-2- yl)methanaminium 2,2,2- trifluoroacetate::US10221163, Example 110::US10544130, Example 110 Metallo-beta-lactamase type 2 0.346 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360954 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360954&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135310930 386400344 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713227 Nc1nc2c(cccc2s1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)NC1C2CNCC12 360955 6-(4-(2- aminobenzo[d] thiazol-4-yl)-2- sulfamoyl-3-(1H- tetrazol-5-yl)phenyl- sulfonamido)-3- azabicyclo[3.1.0] hexan-3-ium 2,2,2- trifluoroacetate::US10221163, Example 111::US10544130, Example 111 Metallo-beta-lactamase type 2 0.429 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360955 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360955&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311089 386400345 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713230 Nc1nc2c(cccc2s1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)NCC1CNCCO1 360956 2-((4-(2- aminobenzo [d]thiazol-4-yl)-2- sulfamoyl-3-(1H- tetrazol-5-yl)phenyl- sulfonamido)methyl) morpholin-4-ium 2,2,2- trifluoroacetate::US10221163, Example 112::US10544130, Example 112 Metallo-beta-lactamase type 2 0.318 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360956 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360956&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311656 386400346 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713233 NC1C2CN(CC12)S(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nnn[nH]2)c1S(N)(=O)=O 360957 (1R,5S,6s)-3-((4-(2- aminobenzo[d] thiazol-4-yl)-2- sulfamoyl-3-(1H- tetrazol-5-yl)phenyl) sulfonyl)-3-aza- bicyclo[3.1.0]hexan- 6-aminium 2,2,2- trifluoroacetate::US10221163, Example 113::US10544130, Example 113 Metallo-beta-lactamase type 2 1.12 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360957 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360957&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 137537541 386400347 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713236 Nc1nc2c(cccc2s1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)NCC1(N)CCOC1 360958 3-((4-(2- aminobenzo [d]thiazol-4-yl)-2- sulfamoyl-3-(1H- tetrazol-5-yl)phenyl- sulfonamido)methyl) tetrahydrofuran- 3-aminium formate::US10221163, Example 114::US10544130, Example 114 Metallo-beta-lactamase type 2 0.298 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360958 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360958&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311282 386400348 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713239 Nc1nc2c(cccc2s1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)NCC1(N)CCOCC1 InChI=1S/C20H23N9O5S3/c21-19-25-16-12(2-1-3-13(16)35-19)11-4-5-14(17(36(23,30)31)15(11)18-26-28-29-27-18)37(32,33)24-10-20(22)6-8-34-9-7-20/h1-5,24H,6-10,22H2,(H2,21,25)(H2,23,30,31)(H,26,27,28,29) RPFSQALYXQGHSI-UHFFFAOYSA-N 360959 4-((4-(2- aminobenzo[d] thiazol-4-yl)-2- sulfamoyl-3-(1H- tetrazol-5-yl)phenyl- sulfonamido)methyl) tetrahydro-2H- pyran-4-aminium formate::US10221163, Example 115::US10544130, Example 115 Metallo-beta-lactamase type 2 0.324 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360959 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360959&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311956 386400349 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713242 CC(CN)NS(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nnn[nH]2)c1S(N)(=O)=O 360960 2-(4-(2- aminobenzo[d] thiazol-4-yl)-2- sulfamoyl-3-(1H- tetrazol-5-yl)phenyl- sulfonamido)propan- 1-aminium formate::US10221163, Example 116::US10544130, Example 116 Metallo-beta-lactamase type 2 0.267 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360960 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360960&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135310997 386400350 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713983 NC[C@H](CO)NS(=O)(=O)c1ccc(-c2cccc(N)n2)c(-c2nn[nH]n2)c1S(N)(=O)=O 361207 (R)—N1-(1-amino-3-hydroxypropan-2-yl)-4-(6-aminopyridin-2-yl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 364::US10544130, Example 364 Metallo-beta-lactamase type 2 14.6 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361207 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361207&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311380 386400596 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713986 N[C@@H](CO)CNS(=O)(=O)c1ccc(-c2ccc(N)nc2)c(-c2nn[nH]n2)c1S(N)(=O)=O 361208 (R)—N1-(2-amino-3-hydroxypropyl)-4-(6-aminopyridin-3-yl)-3-(2H-tetrazol-5-yl) benzene-1,2-disulfonamide::US10221163, Example 365::US10544130, Example 365 Metallo-beta-lactamase type 2 0.590 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361208 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361208&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124158566 386400597 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713989 Nc1nc2c(cccc2s1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)NC[C@]1(N)CCNC1 361209 (S)-4-(2-aminobenzo[d]thiazol-4-yl)-N1-((3-aminopyrrolidin-3-yl)methyl)-3-(2H-tetrazol-5-yl) benzene-1,2-disulfonamide::US10221163, Example 366::US10544130, Example 366 Metallo-beta-lactamase type 2 0.075 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361209 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361209&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311474 386400598 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713992 Nc1nc2c(cccc2s1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)NC[C@@]1(N)CCNC1 361210 (R)-4-(2-aminobenzo[d]thiazol-4-yl)-N1-((3-aminopyrrolidin-3-yl)methyl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 367::US10544130, Example 367 Metallo-beta-lactamase type 2 0.077 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361210 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361210&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135310718 386400599 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713995 Nc1ccc(cn1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)NC[C@]1(N)CCNC1 361211 (S)-4-(6-aminopyridin-3-yl)-N1-((3-aminopyrrolidin-3-yl)methyl)-3-(2H -tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 368::US10544130, Example 368 Metallo-beta-lactamase type 2 0.304 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361211 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361211&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311698 386400600 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713998 Nc1ccc(cn1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)NC[C@@]1(N)CCNC1 361212 (R)-4-(6-aminopyridin-3-yl)-N1-((3-aminopyrrolidin-3-yl)methyl)-3-(2H -tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 369::US10544130, Example 369 Metallo-beta-lactamase type 2 0.508 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361212 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361212&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135310761 386400601 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 714001 NC[C@H](N)CNS(=O)(=O)c1ccc(-c2cccc3[nH]c(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C17H19N11O4S2/c18-6-8(19)7-22-34(31,32)12-5-4-9(10-2-1-3-11-14(10)24-17(20)23-11)13(15(12)33(21,29)30)16-25-27-28-26-16/h1-5,8,22H,6-7,18-19H2,(H2,20,23)(H2,21,29,30)/b10-9+/t8-/m0/s1 AFCPLFGHFODPGV-VPOJCXOPSA-N 361213 (S)-4-(2-amino-1H-benzo[d]imidazol-4-yl)-N1-(2,3-di aminopropyl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 370::US10544130, Example 370 Metallo-beta-lactamase type 2 0.663 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361213 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361213&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135310989 386400602 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 714004 NC[C@H](N)CNS(=O)(=O)c1ccc(-c2cccc3ccc(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O 361214 (S)-4-(2-aminoquinolin-8-yl)-N1-(2,3-diaminopropyl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 371::US10544130, Example 371 Metallo-beta-lactamase type 2 0.289 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361214 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361214&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124158515 386400603 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 714007 NC[C@H](N)CNS(=O)(=O)c1ccc(-c2cnc(N)s2)c(-c2nn[nH]n2)c1S(N)(=O)=O 361215 (S)-4-(2-aminothiazol-5- yl)-N1-(2,3- diaminopropyl)-3-(2H- tetrazol-5-yl)benzene-1,2- disulfonamide::US10221163, Example 372::US10544130, Example 372 Metallo-beta-lactamase type 2 1.27 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361215 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361215&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311600 386400604 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 714010 NC[C@H](N)CNS(=O)(=O)c1ccc(-c2cnc3cc[nH]c3c2)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C17H18N10O4S2/c18-6-10(19)8-23-33(30,31)14-2-1-11(9-5-13-12(22-7-9)3-4-21-13)15(16(14)32(20,28)29)17-24-26-27-25-17/h1-5,7,10,23H,6,8,18-19H2,(H2,20,28,29)/b11-9-/t10-/m0/s1 CXRCAVIUGHWDFE-RGAIUGGKSA-N 361216 (S)-N1-(2,3- diaminopropyl)-4-(1H- pyrrolo[3,2-b]pyridin-6-yl)- 3-(2H-tetrazol-5- yl)benzene-1,2- disulfonamide::US10221163, Example 373::US10544130, Example 373 Metallo-beta-lactamase type 2 0.495 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361216 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361216&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269273 386400605 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 714013 NC[C@H](N)CNS(=O)(=O)c1ccc(-c2cccn3ccnc23)c(-c2nn[nH]n2)c1S(N)(=O)=O 361217 (S)-N1-(2,3- diaminopropyl)-4- (imidazo[1,2-a]pyridin-8- yl)-3-(2H-tetrazol-5- yl)benzene-1,2- disulfonamide::US10221163, Example 374::US10544130, Example 374 Metallo-beta-lactamase type 2 0.278 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361217 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361217&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135310685 386400606 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 714016 NC[C@@H](N)CNS(=O)(=O)c1ccc(-c2cccc3[nH]c(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C17H19N11O4S2/c18-6-8(19)7-22-34(31,32)12-5-4-9(10-2-1-3-11-14(10)24-17(20)23-11)13(15(12)33(21,29)30)16-25-27-28-26-16/h1-5,8,22H,6-7,18-19H2,(H2,20,23)(H2,21,29,30)/b10-9+/t8-/m1/s1 AFCPLFGHFODPGV-KGSKPCQNSA-N 361218 (R)-4-(2-amino-1H-benzo[d]imidazol-4-yl)-N1-(2,3-diaminopropyl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 375::US10544130, Example 375 Metallo-beta-lactamase type 2 0.600 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361218 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361218&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311053 386400607 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 714019 NC[C@@H](N)CNS(=O)(=O)c1ccc(-c2cccc3ccc(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O 361219 (R)-4-(2-aminoquinolin- 8-yl)-N1-(2,3- diaminopropyl)-3-(2H- tetrazol-5-yl)benzene- 1,2-disulfonamide::US10221163, Example 376::US10544130, Example 376 Metallo-beta-lactamase type 2 0.273 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361219 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361219&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269274 386400608 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 714022 NC[C@@H](N)CNS(=O)(=O)c1ccc(-c2cnc(N)s2)c(-c2nn[nH]n2)c1S(N)(=O)=O 361220 (R)-4-(2-aminothiazol-5- yl)-N1-(2,3- diaminopropyl)-3-(2H- tetrazol-5-yl)benzene- 1,2-disulfonamide::US10221163, Example 377::US10544130, Example 377 Metallo-beta-lactamase type 2 1.18 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361220 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361220&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311851 386400609 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 714025 NC[C@@H](N)CNS(=O)(=O)c1ccc(-c2cnc3cc[nH]c3c2)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C17H18N10O4S2/c18-6-10(19)8-23-33(30,31)14-2-1-11(9-5-13-12(22-7-9)3-4-21-13)15(16(14)32(20,28)29)17-24-26-27-25-17/h1-5,7,10,23H,6,8,18-19H2,(H2,20,28,29)/b11-9-/t10-/m1/s1 CXRCAVIUGHWDFE-QLWWJYNRSA-N 361221 (R)-N1-(2,3- diaminopropyl)-4-(1H- pyrrolo[3,2-b]pyridin-6- yl)-3-(2H-tetrazol- 5-yl)benzene-1,2- disulfonamide::US10221163, Example 378::US10544130, Example 378 Metallo-beta-lactamase type 2 0.354 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361221 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361221&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269275 386400610 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 714028 NC[C@@H](CO)NS(=O)(=O)c1ccc(-c2cccc3[nH]c(CN)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C18H20N10O5S2/c19-6-9(8-29)26-35(32,33)13-5-4-10(11-2-1-3-12-16(11)23-14(7-20)22-12)15(17(13)34(21,30)31)18-24-27-28-25-18/h1-5,9,26,29H,6-8,19-20H2,(H2,21,30,31)/b11-10+/t9-/m0/s1 WYNKHXHXYYJZQW-YHTNPHCKSA-N 361222 (S)—N1-(1-amino-3-hydroxypropan-2-yl)-4-(2-(aminomethyl)-1H-benzo[d]imidazol-4-yl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 379::US10544130, Example 379 Metallo-beta-lactamase type 2 0.626 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361222 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361222&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311289 386400611 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 714031 NC[C@@H](CO)NS(=O)(=O)c1ccc(-c2ccnc(N)c2)c(-c2nn[nH]n2)c1S(N)(=O)=O 361223 (S)—N1-(1-amino-3-hydroxypropan-2-yl)-4-(2-aminopyridin-4-yl)-3-(2H -tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 380::US10544130, Example 380 Metallo-beta-lactamase type 2 0.544 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361223 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361223&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135310773 386400612 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 714034 NC[C@@H](CO)NS(=O)(=O)c1ccc(-c2cccc3sc(CN)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O 361224 (S)—N1-(1-amino-3-hydroxypropan-2-yl)-4-(2-(aminomethyl)benzo[d]thiazol-4-yl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 381::US10544130, Example 381 Metallo-beta-lactamase type 2 0.241 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361224 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361224&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311161 386400613 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 714037 NC[C@@H](CO)NS(=O)(=O)c1ccc(-c2cccc(N)n2)c(-c2nn[nH]n2)c1S(N)(=O)=O 361225 (S)—N1-(1-amino-3-hydroxypropan-2-yl)-4-(6-aminopyridin-2-yl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 382::US10544130, Example 382 Metallo-beta-lactamase type 2 0.651 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361225 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361225&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135310831 386400614 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 714040 C[C@H](CN)NS(=O)(=O)c1ccc(-c2cccc3[nH]c(CN)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C18H20N10O4S2/c1-9(7-19)26-34(31,32)13-6-5-10(11-3-2-4-12-16(11)23-14(8-20)22-12)15(17(13)33(21,29)30)18-24-27-28-25-18/h2-6,9,26H,7-8,19-20H2,1H3,(H2,21,29,30)/b11-10+/t9-/m1/s1 WDZGUMLHLJCPQL-HNLKAFMCSA-N 361226 (R)-4-(2-(aminomethyl)-1H-benzo[d]imidazol-4-yl)-N1-(1-aminopropan-2-yl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 383::US10544130, Example 383 Metallo-beta-lactamase type 2 0.536 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361226 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361226&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311365 386400615 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713245 CC(C)(CN)NS(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nnn[nH]2)c1S(N)(=O)=O InChI=1S/C18H21N9O4S3/c1-18(2,8-19)25-34(30,31)12-7-6-9(10-4-3-5-11-14(10)22-17(20)32-11)13(15(12)33(21,28)29)16-23-26-27-24-16/h3-7,25H,8,19H2,1-2H3,(H2,20,22)(H2,21,28,29)(H,23,24,26,27) QJGBZMFDMGHLPK-UHFFFAOYSA-N 360961 2-(4-(2- aminobenzo[d] thiazol-4-yl)-2- sulfamoyl-3-(1H- tetrazol-5-yl)phenyl- sulfonamido)-2- methylpropan-1- aminium formate::US10221163, Example 117::US10544130, Example 117 Metallo-beta-lactamase type 2 0.243 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360961 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360961&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135310670 386400351 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713248 NC(CNS(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nnn[nH]2)c1S(N)(=O)=O)C(F)F 360962 3-(4-(2-aminobenzo [d]thiazol-4-yl)-2- sulfamoyl-3-(1H- tetrazol-5-yl)phenyl- sulfonamido)-1,1- difluoropropan-2- aminium formate::US10221163, Example 118::US10544130, Example 118 Metallo-beta-lactamase type 2 0.331 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360962 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360962&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311143 386400352 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713251 Nc1nc2c(cccc2s1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)NC1C[C@@H]2CN[C@H]1C2 360963 4-(2-aminobenzo [d[thiazol-4-yl)-N1- ((1S,4R)-2-azabicyclo [2.2.1]heptan-6-yl)- 3-(1H-tetrazol-5- yl)benzene-1,2- disulfonamide, formate salt::US10221163, Example 119::US10544130, Example 119 Metallo-beta-lactamase type 2 0.223 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360963 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360963&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311742 386400353 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713254 Nc1nc2c(cccc2s1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)NCC1CCNC1 360964 3-((4-(2-aminobenzo [d]thiazol-4-yl)-2- sulfamoyl-3-(1H- tetrazol-5-yl)phenyl- sulfonamido)methyl) pyrrolidin-1-ium formate::US10221163, Example 120::US10544130, Example 120 Metallo-beta-lactamase type 2 0.258 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360964 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360964&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311231 386400354 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713257 CN(C[C@@H]1CCCN1)S(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nnn[nH]2)c1S(N)(=O)=O 360965 (S)-2-((4-(2- aminobenzo[d] thiazol-4-yl)-N- methyl-2-sulfamoyl- 3-(1H-tetrazol-5-yl) phenylsulfonamido) methyl)pyrrolidin-1- ium formate::US10221163, Example 121::US10544130, Example 121 Metallo-beta-lactamase type 2 2.84 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360965 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360965&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311062 386400355 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713260 Nc1nc2c(cccc2s1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)NC[C@]1(F)CCCNC1 360966 (S)-3-(((4-(2- aminobenzo [d]thiazol-4-yl)-2- sulfamoyl-3-(1H- tetrazol-5-yl)phenyl) sulfonamido)methyl)- 3-fluoropiperidin- 1-ium formate::US10221163, Example 122::US10544130, Example 122 Metallo-beta-lactamase type 2 0.282 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360966 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360966&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311517 386400356 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713263 NC(CF)CCNS(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nnn[nH]2)c1S(N)(=O)=O 360967 4-(4-(2-aminobenzo [d]thiazol-4-yl)-2- sulfamoyl-3- (1H-tetrazol-5-yl) phenylsulfonamido)- 1-fluorobutan-2- aminium formate::US10221163, Example 123::US10544130, Example 123 Metallo-beta-lactamase type 2 0.219 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360967 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360967&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135310824 386400357 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713266 NC(CCNS(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nnn[nH]2)c1S(N)(=O)=O)C(F)F 360968 4-(4-(2-aminobenzo [d]thiazol-4-yl)-2- sulfamoyl-3-(1H- tetrazol-5-yl)phenyl- sulfonamido)-1,1- difluorobutan-2- aminium formate::US10221163, Example 124::US10544130, Example 124 Metallo-beta-lactamase type 2 0.222 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360968 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360968&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311503 386400358 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713269 Nc1nc2c(cccc2s1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)NC[C@@H]1CCCN1 360969 (S)-2-((4-(2- aminobenzo [d]thiazol-4-yl)-2- sulfamoyl-3-(1H- tetrazol-5-yl)phenyl- sulfonamido)methyl) pyrrolidin-1- ium formate::US10221163, Example 125::US10544130, Example 125 Metallo-beta-lactamase type 2 0.286 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360969 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360969&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311859 386400359 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713272 Nc1nc2c(cccc2s1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)NC[C@H]1CCCN1 360970 (R)-2-((4-(2- aminobenzo [d]thiazol-4-yl)-2- sulfamoyl-3- (1H-tetrazol-5-yl) phenylsulfonamido) methyl)pyrrolidin-1- ium formate::US10221163, Example 126::US10544130, Example 126 Metallo-beta-lactamase type 2 0.222 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360970 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360970&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311310 386400360 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713275 C[C@H](N)CNS(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nnn[nH]2)c1S(N)(=O)=O 360971 (S)-4-(2-aminobenzo [d]thiazol-4-yl)-N1- (2-aminopropyl)- 3-(1H-tetrazol-5- yl)benzene-1,2- disulfonamide, formate salt::US10221163, Example 127::US10544130, Example 127 Metallo-beta-lactamase type 2 0.322 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360971 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360971&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311402 386400361 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713278 COC(=O)[C@H]1C[C@H](CN1)NS(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nnn[nH]2)c1S(N)(=O)=O 360972 Methyl (2R,4R)-4-((4-(2-aminobenzo[d]thiazol-4-yl)-2-sulfamoyl-3-(1H-tetrazol-5-yl)phenyl)sulfonamido)pyrrolidine-2-carboxylate::US10221163, Example 128::US10544130, Example 128 Metallo-beta-lactamase type 2 0.177 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360972 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360972&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124159693 386400362 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713281 CN(C)C(=O)c1ccccc1-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)N[C@@H]1CCNC1 360973 (R)-N,N-dimethyl-4'-(N- (pyrrolidin-3-yl)sulfamoyl)-3'- sulfamoyl-2'-(1H-tetrazol-5-yl)- [1,1'-biphenyl]-2-carboxamide::US10221163, Example 129::US10544130, Example 129 Metallo-beta-lactamase type 2 9.07 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360973 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360973&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311594 386400363 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713284 NS(=O)(=O)c1c(ccc(-c2cccc3nc(O)[nH]c23)c1-c1nnn[nH]1)S(=O)(=O)N[C@@H]1CCNC1 InChI=1S/C18H17N9O5S2/c19-33(29,30)16-13(34(31,32)25-9-6-7-20-8-9)5-4-10(14(16)17-23-26-27-24-17)11-2-1-3-12-15(11)22-18(28)21-12/h1-5,9,20,25H,6-8H2,(H,21,28)(H2,19,29,30)/b11-10+/t9-/m1/s1 WOINWUWKNUOGCI-HNLKAFMCSA-N 360974 (R)-4-(2-hydroxy-1H- benzo[d]imidazol-7-yl)-N1- (pyrrolidin-3-yl)-3-(1H-tetrazol- 5-yl)benzene-1,2-disulfonamide::US10221163, Example 130::US10544130, Example 130 Metallo-beta-lactamase type 2 0.684 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360974 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360974&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269202 386400364 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713287 NS(=O)(=O)c1c(ccc(-c2cccc3OC(F)(F)Oc23)c1-c1nnn[nH]1)S(=O)(=O)N[C@@H]1CCNC1 360975 (R)-4-(2,2- difluorobenzo[d][1,3]dioxol-4- yl)-N1-(pyrrolidin-3-yl)-3-(1H- tetrazol-5-yl)benzene-1,2- disulfonamide::US10221163, Example 131::US10544130, Example 131 Metallo-beta-lactamase type 2 1.83 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360975 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360975&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269203 386400365 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713290 Nc1c(cccc1-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)N[C@@H]1CCNC1)C#N 360976 (R)-2'-amino-3'-cyano-N4- (pyrrolidin-3-yl)-2-(1H-tetrazol- 5-yl)-[1,1'-biphenyl]-3,4- disulfonamide::US10221163, Example 132::US10544130, Example 132 Metallo-beta-lactamase type 2 1.40 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360976 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360976&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135310829 386400366 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713293 NS(=O)(=O)c1c(ccc(-c2ccc3nonc3c2)c1-c1nnn[nH]1)S(=O)(=O)N[C@@H]1CCNC1 360977 (R)-4-(benzo[c][1,2,5]oxadiazol- 5-yl)-N1-(pyrrolidin-3-yl)-3- (1H-tetrazol-5-yl)benzene-1,2- disulfonamide::US10221163, Example 133::US10544130, Example 133 Metallo-beta-lactamase type 2 0.816 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360977 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360977&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135310703 386400367 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713296 Cn1nnc2ccc(cc12)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)N[C@@H]1CCNC1 360978 (R)-4-(1-methyl-1H- benzo[d][1,2,3]triazol-6-yl)-N1- (pyrrolidin-3-yl)-3-(1H-tetrazol- 5-yl)benzene-1,2-disulfonamide::US10221163, Example 134::US10544130, Example 134 Metallo-beta-lactamase type 2 2.07 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360978 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360978&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135310950 386400368 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713299 NS(=O)(=O)c1ccc(cc1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)N[C@@H]1CCNC1 360979 (R)-N4-(pyrrolidin-3-yl)-2-(1H- tetrazol-5-yl)-[1,1'-biphenyl]- 3,4,4'-trisulfonamide::US10221163, Example 135::US10544130, Example 135 Metallo-beta-lactamase type 2 0.229 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360979 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360979&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311131 386400369 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713302 CS(=O)(=O)Nc1ccc(cc1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)N[C@@H]1CCNC1 360980 (R)-4'-(methylsulfonamido)-N4- (pyrrolidin-3-yl)-2-(1H-tetrazol- 5-yl)-[1,1'-biphenyl]-3,4- disulfonamide::US10221163, Example 136::US10544130, Example 136 Metallo-beta-lactamase type 2 0.075 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360980 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360980&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311601 386400370 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 714043 C[C@H](CN)NS(=O)(=O)c1ccc(-c2cccn3ccnc23)c(-c2nn[nH]n2)c1S(N)(=O)=O 361227 (R)—N1-(1-aminopropan-2-yl)-4-(imidazo[1,2-a]pyridin-8-yl)-3-(2H -tetrazol-5-yl) benzene-1,2-disulfonamide::US10221163, Example 384::US10544130, Example 384 Metallo-beta-lactamase type 2 0.054 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361227 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361227&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124158552 386400616 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 714046 NCC(CN)NS(=O)(=O)c1ccc(-c2cccc3[nH]c(CN)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C18H23N11O4S2/c19-6-9(7-20)27-35(32,33)13-5-4-10(11-2-1-3-12-16(11)24-14(8-21)23-12)15(17(13)34(22,30)31)18-25-28-29-26-18/h1-5,9,27H,6-8,19-21H2,(H,23,24)(H2,22,30,31)(H,25,26,28,29) BFDZAXLYGMAZBQ-UHFFFAOYSA-N 361228 4-(2-(Aminomethyl)-1H-benzo[d]imidazol-4-yl)-N1-(1,3-diaminopropan-2-yl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 385::US10544130, Example 385 Metallo-beta-lactamase type 2 0.782 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361228 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361228&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311729 386400617 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 714049 NCC(CN)NS(=O)(=O)c1ccc(-c2cccn3ccnc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C17H20N10O4S2/c18-8-10(9-19)24-33(30,31)13-4-3-11(12-2-1-6-27-7-5-21-17(12)27)14(15(13)32(20,28)29)16-22-25-26-23-16/h1-7,10,24H,8-9,18-19H2,(H2,20,28,29)(H,22,23,25,26) KCQQRBQSGGONSX-UHFFFAOYSA-N 361229 N1-(1,3-diaminopropan-2-yl)-4-(imidazo[1,2-c]pyridin-8-yl)-3-(2H-tetrazol-5-yl) benzene-1,2-disulfonamide::US10221163, Example 386::US10544130, Example 386 Metallo-beta-lactamase type 2 0.141 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361229 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361229&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 137537738 386400618 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 714052 Nc1nc2c(cccc2s1)-c1ccc(c(c1-c1nn[nH]n1)S(=O)=O)S(=O)(=O)NCC1(O)CNC1 InChI=1S/C18H18N8O5S3/c19-17-22-14-10(2-1-3-11(14)32-17)9-4-5-12(34(30,31)21-8-18(27)6-20-7-18)15(33(28)29)13(9)16-23-25-26-24-16/h1-5,20-21,27,33H,6-8H2,(H2,19,22)(H,23,24,25,26) WOEHJDYFWVSMFE-UHFFFAOYSA-N 361230 4-(2-amino-1,3- benzothiazol-4-yl)- N1-[(3- hydroxyazetidin-3- yl)methyl]-3-(2H- tetrazol-5- yl)benzene-1,2- disulfonamide::US10221163, Example 387 Metallo-beta-lactamase type 2 0.244 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361230 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361230&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 137537611 386400619 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 714055 N[C@@H]1C[C@H]1NS(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nn[nH]n2)c1S(=O)=O 361231 4-(2-amino-1,3- benzothiazol-4-yl)- N1-[(1R,2R)-2- aminocyclopropyl]-3- (2H-tetrazol-5- yl)benzene-1,2- disulfonamide::US10221163, Example 388 Metallo-beta-lactamase type 2 0.324 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361231 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361231&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 137537518 386400620 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 714058 C[C@@H](CN)NS(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nn[nH]n2)c1S(=O)=O 361232 4-(2-amino-1,3- benzothiazol-4-yl)- N1-[(1S)-2-amino-1- methylethyl]-3-(2H- tetrazol-5- yl)benzene-1,2- disulfonamide::US10221163, Example 389 Metallo-beta-lactamase type 2 1.81 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361232 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361232&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 137537714 386400621 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 714061 C[C@@H](N)CNS(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nn[nH]n2)c1S(=O)=O 361233 4-(2-amino-1,3- benzothiazol-4-yl)- N1-[(2R)-2- aminopropyl]-3-(2H- tetrazol-5- yl)benzene-1,2- disulfonamide::US10221163, Example 390 Metallo-beta-lactamase type 2 0.341 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361233 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361233&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 137537593 386400622 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 714064 C[N+](C)(C)CCNS(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nn[nH]n2)c1S(=O)=O InChI=1S/C19H23N8O4S3/c1-27(2,3)10-9-21-34(30,31)14-8-7-11(12-5-4-6-13-16(12)22-19(20)32-13)15(17(14)33(28)29)18-23-25-26-24-18/h4-8,21,33H,9-10H2,1-3H3,(H2,20,22)(H,23,24,25,26)/q+1 XXMMMNLRBCLZOO-UHFFFAOYSA-N 361234 2-({[4-(2-amino-1,3- benzothiazol-4-yl)-2- sulfamoyl-3-(1H- tetrazol-5- yl)phenyl]sulfonyl} amino)-N,N,N- trimethylethanaminium trifluoroacetate::US10221163, Example 391 Metallo-beta-lactamase type 2 0.209 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361234 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361234&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269276 386400623 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 714067 C[N+](C)(C)CCCNS(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nn[nH]n2)c1S(=O)=O InChI=1S/C20H25N8O4S3/c1-28(2,3)11-5-10-22-35(31,32)15-9-8-12(13-6-4-7-14-17(13)23-20(21)33-14)16(18(15)34(29)30)19-24-26-27-25-19/h4,6-9,22,34H,5,10-11H2,1-3H3,(H2,21,23)(H,24,25,26,27)/q+1 ZWFYTQIIAPACPO-UHFFFAOYSA-N 361235 3-({[4-(2-amino-1,3- benzothiazol-4-yl)-2- sulfamoyl-3-(1H- tetrazol-5- yl)phenyl]sulfonyl} amino)-N,N,N- trimethylpropan-1- aminium trifluoroacetate::US10221163, Example 392 Metallo-beta-lactamase type 2 0.221 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361235 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361235&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269278 386400624 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 714070 C[C@H](CN)NS(=O)(=O)c1ccc(-c2ccc(N)nc2)c(-c2nn[nH]n2)c1S(N)(=O)=O 361236 (R)—N1-(1-aminopropan-2-yl)-4-(6-aminopyridin-3-yl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 393::US10544130, Example 393 Metallo-beta-lactamase type 2 0.063 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361236 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361236&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124158292 386400625 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 714073 C[C@@H](CN)NS(=O)(=O)c1ccc(-c2ccc(N)nc2)c(-c2nn[nH]n2)c1S(N)(=O)=O 361237 US10221163, Example 394::US10544130, Example 394 Metallo-beta-lactamase type 2 2.00 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361237 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361237&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269280 386400626 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 714076 C[C@H](CN)NS(=O)(=O)c1ccc(-c2cccc3n(C)c(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O 361238 US10221163, Example 395::US10544130, Example 395 Metallo-beta-lactamase type 2 0.156 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361238 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361238&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269281 386400627 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 714079 C[C@H](CN)NS(=O)(=O)c1ccc(-c2cc(F)cc3[nH]c(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C17H17FN10O4S2/c1-7(6-19)26-34(31,32)12-3-2-9(10-4-8(18)5-11-14(10)23-17(20)22-11)13(15(12)33(21,29)30)16-24-27-28-25-16/h2-5,7,26H,6,19H2,1H3,(H2,20,22)(H2,21,29,30)/b10-9+/t7-/m1/s1 CNLLIMMZIIFSRY-KOUNZKNHSA-N 361239 US10221163, Example 396::US10544130, Example 396 Metallo-beta-lactamase type 2 0.221 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361239 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361239&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269282 386400628 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 714082 C[C@@H](CN)NS(=O)(=O)c1ccc(-c2cc(F)cc3[nH]c(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C17H17FN10O4S2/c1-7(6-19)26-34(31,32)12-3-2-9(10-4-8(18)5-11-14(10)23-17(20)22-11)13(15(12)33(21,29)30)16-24-27-28-25-16/h2-5,7,26H,6,19H2,1H3,(H2,20,22)(H2,21,29,30)/b10-9+/t7-/m0/s1 CNLLIMMZIIFSRY-YLZOWGOUSA-N 361240 US10221163, Example 397::US10544130, Example 397 Metallo-beta-lactamase type 2 1.60 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361240 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361240&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269283 386400629 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 714085 C[C@@H](CN)NS(=O)(=O)c1ccc(-c2ccnc(N)c2)c(-c2nn[nH]n2)c1S(N)(=O)=O 361241 US10221163, Example 398::US10544130, Example 398 Metallo-beta-lactamase type 2 7.45 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361241 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361241&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269284 386400630 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 714088 Nc1nc2c(cc(F)cc2[nH]1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)N[C@H]1CCNC1 InChI=1S/C18H17FN10O4S2/c19-8-5-11(15-12(6-8)23-18(20)24-15)10-1-2-13(35(32,33)27-9-3-4-22-7-9)16(34(21,30)31)14(10)17-25-28-29-26-17/h1-2,5-6,9,22,27H,3-4,7H2,(H2,20,23)(H2,21,30,31)/b11-10+/t9-/m0/s1 SXTBYHWGGXCMBX-YHTNPHCKSA-N 361242 US10221163, Example 399::US10544130, Example 399 Metallo-beta-lactamase type 2 0.533 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361242 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361242&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 137537617 386400631 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 714091 NCCNS(=O)(=O)c1ccc(-c2ccnc(N)c2)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C14H17N9O4S2/c15-4-6-19-29(26,27)10-2-1-9(8-3-5-18-11(16)7-8)12(13(10)28(17,24)25)14-20-22-23-21-14/h1-3,5,7,19H,4,6,15H2,(H2,16,18)(H2,17,24,25)(H,20,21,22,23) RRTXSFAFHOPSAU-UHFFFAOYSA-N 361243 US10221163, Example 400::US10544130, Example 400 Metallo-beta-lactamase type 2 1.42 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361243 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361243&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 137537559 386400632 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 714094 NCCNS(=O)(=O)c1ccc(-c2ccc3nccn3c2)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C16H17N9O4S2/c17-5-6-20-31(28,29)12-3-2-11(10-1-4-13-19-7-8-25(13)9-10)14(15(12)30(18,26)27)16-21-23-24-22-16/h1-4,7-9,20H,5-6,17H2,(H2,18,26,27)(H,21,22,23,24) CAPREPJCVIJSJF-UHFFFAOYSA-N 361244 US10221163, Example 401::US10544130, Example 401 Metallo-beta-lactamase type 2 0.483 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361244 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361244&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 137537529 386400633 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 714097 NCCCNS(=O)(=O)c1ccc(-c2cc(F)cc3[nH]c(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C17H19FN10O4S2/c18-8-6-10(14-11(7-8)23-17(20)24-14)9-2-3-12(34(31,32)22-5-1-4-19)15(33(21,29)30)13(9)16-25-27-28-26-16/h2-3,6-7,22H,1,4-5,19H2,(H3,20,23,24)(H2,21,29,30)(H,25,26,27,28) WWOWQFNSNPLLCR-UHFFFAOYSA-N 361245 US10221163, Example 402::US10544130, Example 402 Metallo-beta-lactamase type 2 0.318 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361245 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361245&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 137537710 386400634 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 714100 NCC(CN)NS(=O)(=O)c1ccc(-c2cccc3[nH]nnc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C16H19N11O4S2/c17-6-8(7-18)24-33(30,31)12-5-4-9(10-2-1-3-11-14(10)21-25-20-11)13(15(12)32(19,28)29)16-22-26-27-23-16/h1-5,8,24H,6-7,17-18H2,(H2,19,28,29)(H,20,21,25)(H,22,23,26,27) AFJIDACMIUWLIM-UHFFFAOYSA-N 361246 US10221163, Example 403::US10544130, Example 403 Metallo-beta-lactamase type 2 0.531 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361246 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361246&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 137537717 386400635 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713305 NC(=O)c1ccc(cc1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)N[C@@H]1CCNC1 360981 (R)-4'-(N-(pyrrolidin-3- yl)sulfamoyl)-3'-sulfamoyl-2'- (1H-tetrazol-5-yl)-[1,1'- biphenyl]-4-carboxamide::US10221163, Example 137::US10544130, Example 137 Metallo-beta-lactamase type 2 0.265 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360981 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360981&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311648 386400371 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713308 NS(=O)(=O)c1c(ccc(-c2ccc3CNC(=O)c3c2)c1-c1nnn[nH]1)S(=O)(=O)N[C@@H]1CCNC1 360982 (R)-4-(3-oxoisoindolin-5-yl)-N1- (pyrrolidin-3-yl)-3-(1H-tetrazol- 5-yl)benzene-1,2-disulfonamide::US10221163, Example 138::US10544130, Example 138 Metallo-beta-lactamase type 2 0.275 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360982 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360982&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311413 386400372 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713311 NS(=O)(=O)c1c(ccc(-c2cccc3cn[nH]c23)c1-c1nnn[nH]1)S(=O)(=O)N[C@@H]1CCNC1 InChI=1S/C18H17N9O4S2/c19-32(28,29)17-14(33(30,31)25-11-6-7-20-9-11)5-4-12(15(17)18-23-26-27-24-18)13-3-1-2-10-8-21-22-16(10)13/h1-5,8,11,20,25H,6-7,9H2,(H2,19,28,29)/b13-12+/t11-/m1/s1 GYELOXHNEKJFSR-GXZRWPEMSA-N 360983 (R)-4-(1H-indazol-7-yl)-N1- (pyrrolidin-3-yl)-3-(1H-tetrazol- 5-yl)benzene-1,2-disulfonamide::US10221163, Example 139::US10544130, Example 139 Metallo-beta-lactamase type 2 0.410 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360983 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360983&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311574 386400373 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713314 NS(=O)(=O)c1c(ccc(-c2cnc3ccccn23)c1-c1nnn[nH]1)S(=O)(=O)N[C@@H]1CCNC1 360984 (R)-4-(imidazo[1,2-a]pyridin-3- yl)-N1-(pyrrolidin-3-yl)-3-(1H- tetrazol-5-yl)benzene-1,2- disulfonamide::US10221163, Example 140::US10544130, Example 140 Metallo-beta-lactamase type 2 0.779 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360984 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360984&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311521 386400374 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713317 C[C@H]1NC(=O)O[C@H]1c1ccc(cc1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)N[C@@H]1CCNC1 360985 4'-((4R,5S)-4-methyl-2- oxooxazolidin-5-yl)-N4-((R)- pyrrolidin-3-yl)-2-(1H-tetrazol- 5-yl)-[1,1'-biphenyl]-3,4- disulfonamide::US10221163, Example 141::US10544130, Example 141 Metallo-beta-lactamase type 2 0.041 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360985 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360985&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269204 386400375 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713320 Nc1nc2c(cccc2s1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)N1CCNCC1 InChI=1S/C18H19N9O4S3/c19-18-22-15-11(2-1-3-12(15)32-18)10-4-5-13(34(30,31)27-8-6-21-7-9-27)16(33(20,28)29)14(10)17-23-25-26-24-17/h1-5,21H,6-9H2,(H2,19,22)(H2,20,28,29)(H,23,24,25,26) YFQVRYQHRYRIBR-UHFFFAOYSA-N 360986 3-(2-Aminobenzo[d]thiazol-4-yl)-6-(piperazin-1-ylsulfonyl)-2-(2H-tetrazol-5-yl)benzenesulfonamide::US10221163, Example 142::US10544130, Example 142 Metallo-beta-lactamase type 2 0.636 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360986 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360986&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269205 386400376 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713323 Nc1nc2c(cccc2s1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(N)(=O)=O InChI=1S/C14H12N8O4S3/c15-14-18-11-7(2-1-3-8(11)27-14)6-4-5-9(28(16,23)24)12(29(17,25)26)10(6)13-19-21-22-20-13/h1-5H,(H2,15,18)(H2,16,23,24)(H2,17,25,26)(H,19,20,21,22) DFEIOWJQIXAABN-UHFFFAOYSA-N 360987 4-(2-aminobenzo[d]thiazol-4- yl)-3-(2H-tetrazol-5- yl)benzene-1,2-disulfonamide::US10221163, Example 143::US10544130, Example 143 Metallo-beta-lactamase type 2 0.266 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360987 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360987&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269206 386400377 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713326 Nc1nc2c(cccc2s1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)NCCO InChI=1S/C16H16N8O5S3/c17-16-20-13-9(2-1-3-10(13)30-16)8-4-5-11(32(28,29)19-6-7-25)14(31(18,26)27)12(8)15-21-23-24-22-15/h1-5,19,25H,6-7H2,(H2,17,20)(H2,18,26,27)(H,21,22,23,24) FZQGKUYDMKKPSR-UHFFFAOYSA-N 360988 4-(2-aminobenzo[d]thiazol-4- yl)-N1-(2-hydroxyethyl)-3- (2H-tetrazol-5-yl)benzene-1,2- disulfonamide::US10221163, Example 144::US10544130, Example 144 Metallo-beta-lactamase type 2 0.288 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360988 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360988&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269207 386400378 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713329 NCCNS(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C16H17N9O4S3/c17-6-7-20-32(28,29)11-5-4-8(9-2-1-3-10-13(9)21-16(18)30-10)12(14(11)31(19,26)27)15-22-24-25-23-15/h1-5,20H,6-7,17H2,(H2,18,21)(H2,19,26,27)(H,22,23,24,25) DGBXDGANRYBJPM-UHFFFAOYSA-N 360989 4-(2-aminobenzo[d]thiazol-4- yl)-N1-(2-aminoethyl)-3-(2H- tetrazol-5-yl)benzene-1,2- disulfonamide::US10221163, Example 145::US10544130, Example 145 Metallo-beta-lactamase type 2 0.221 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360989 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360989&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269208 386400379 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713332 Nc1nc2c(cccc2s1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)NC1CNC1 InChI=1S/C17H17N9O4S3/c18-17-21-14-10(2-1-3-11(14)31-17)9-4-5-12(33(29,30)24-8-6-20-7-8)15(32(19,27)28)13(9)16-22-25-26-23-16/h1-5,8,20,24H,6-7H2,(H2,18,21)(H2,19,27,28)(H,22,23,25,26) CADODRJOFDTRLR-UHFFFAOYSA-N 360990 4-(2-aminobenzo[d]thiazol-4- yl)-N1-(azetidin-3-yl)-3-(2H- tetrazol-5-yl)benzene-1,2- disulfonamide::US10221163, Example 146::US10544130, Example 146 Metallo-beta-lactamase type 2 0.356 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360990 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360990&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269209 386400380 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713335 NC1CN(C1)S(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C17H17N9O4S3/c18-8-6-26(7-8)33(29,30)12-5-4-9(10-2-1-3-11-14(10)21-17(19)31-11)13(15(12)32(20,27)28)16-22-24-25-23-16/h1-5,8H,6-7,18H2,(H2,19,21)(H2,20,27,28)(H,22,23,24,25) IOQCZQUVXNEXKO-UHFFFAOYSA-N 360991 6-((3-aminoazetidin-1- yl)sulfonyl)-3-(2- aminobenzo[d]thiazol-4-yl)-2- (2H-tetrazol-5- yl)benzenesulfonamide::US10221163, Example 147::US10544130, Example 147 Metallo-beta-lactamase type 2 0.494 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360991 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360991&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269210 386400381 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713338 NC1CCN(CC1)S(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C19H21N9O4S3/c20-10-6-8-28(9-7-10)35(31,32)14-5-4-11(12-2-1-3-13-16(12)23-19(21)33-13)15(17(14)34(22,29)30)18-24-26-27-25-18/h1-5,10H,6-9,20H2,(H2,21,23)(H2,22,29,30)(H,24,25,26,27) LQLKYWFVAIUUME-UHFFFAOYSA-N 360992 3-(2-aminobenzo[d]thiazol-4- yl)-6-((4-aminopiperidin-1- yl)sulfonyl)-2-(2H-tetrazol-5- yl)benzenesulfonamide::US10221163, Example 148::US10544130, Example 148 Metallo-beta-lactamase type 2 0.490 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360992 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360992&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269211 386400382 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713341 Nc1nc2c(cccc2s1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)NCC1(N)CC1 InChI=1S/C18H19N9O4S3/c19-17-23-14-10(2-1-3-11(14)32-17)9-4-5-12(34(30,31)22-8-18(20)6-7-18)15(33(21,28)29)13(9)16-24-26-27-25-16/h1-5,22H,6-8,20H2,(H2,19,23)(H2,21,28,29)(H,24,25,26,27) LBJBSCVPRJVYAR-UHFFFAOYSA-N 360993 4-(2-aminobenzo[d]thiazol-4- yl)-N1-((1- aminocyclopropyl)methyl)-3- (2H-tetrazol-5-yl)benzene-1,2- disulfonamide::US10221163, Example 149::US10544130, Example 149 Metallo-beta-lactamase type 2 0.993 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360993 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360993&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269212 386400383 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713344 CN(C)S(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C16H16N8O4S3/c1-24(2)31(27,28)11-7-6-8(9-4-3-5-10-13(9)19-16(17)29-10)12(14(11)30(18,25)26)15-20-22-23-21-15/h3-7H,1-2H3,(H2,17,19)(H2,18,25,26)(H,20,21,22,23) GBNKXRKFDOPWQQ-UHFFFAOYSA-N 360994 4-(2-aminobenzo[d]thiazol-4- yl)-N1,N1-dimethyl-3-(2H- tetrazol-5-yl)benzene-1,2- disulfonamide::US10221163, Example 151::US10544130, Example 151 Metallo-beta-lactamase type 2 2.43 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360994 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360994&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269213 386400384 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713347 CNS(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C15H14N8O4S3/c1-18-30(26,27)10-6-5-7(8-3-2-4-9-12(8)19-15(16)28-9)11(13(10)29(17,24)25)14-20-22-23-21-14/h2-6,18H,1H3,(H2,16,19)(H2,17,24,25)(H,20,21,22,23) WUABLXKYUAZXNS-UHFFFAOYSA-N 360995 4-(2-aminobezno[d]thiazol-4- yl)-N1-methyl-3-(2H-tetrazol- 5-yl)benzene-1,2- disulfonamide::US10221163, Example 152::US10544130, Example 152 Metallo-beta-lactamase type 2 0.264 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360995 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360995&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269214 386400385 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713350 Nc1nc2c(cccc2s1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)NCC(O)=O InChI=1S/C16H14N8O6S3/c17-16-20-13-8(2-1-3-9(13)31-16)7-4-5-10(33(29,30)19-6-11(25)26)14(32(18,27)28)12(7)15-21-23-24-22-15/h1-5,19H,6H2,(H2,17,20)(H,25,26)(H2,18,27,28)(H,21,22,23,24) HFOJOTOEYNQQED-UHFFFAOYSA-N 360996 ((4-(2-aminobenzo[d]thiazol- 4-yl)-2-sulfamoyl-3-(2H- tetrazol-5- yl)phenyl)sulfonyl)glycine::US10221163, Example 153::US10544130, Example 153 Metallo-beta-lactamase type 2 0.704 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360996 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360996&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269215 386400386 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713353 N[C@H](CNS(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O)C(O)=O 360997 (R)-2-amino-3-((4-(2- aminobenzo[d]thiazol-4-yl)-2- sulfamoyl-3-(2H-tetrazol-5- yl)phenyl)sulfonamido) propanoic acid::US10221163, Example 154::US10544130, Example 154 Metallo-beta-lactamase type 2 0.155 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360997 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360997&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269216 386400387 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713356 Nc1ccc(cn1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(N)(=O)=O InChI=1S/C12H12N8O4S2/c13-9-4-1-6(5-16-9)7-2-3-8(25(14,21)22)11(26(15,23)24)10(7)12-17-19-20-18-12/h1-5H,(H2,13,16)(H2,14,21,22)(H2,15,23,24)(H,17,18,19,20) XXVBQYHIFYSDQC-UHFFFAOYSA-N 360998 4-(6-Aminopyridin-3-yl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 155::US10544130, Example 155 Metallo-beta-lactamase type 2 0.658 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360998 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360998&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124158281 386400388 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713359 CS(=O)(=O)Nc1nc2c(cccc2s1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)N1CCNCC1 InChI=1S/C19H21N9O6S4/c1-36(29,30)25-19-22-16-12(3-2-4-13(16)35-19)11-5-6-14(38(33,34)28-9-7-21-8-10-28)17(37(20,31)32)15(11)18-23-26-27-24-18/h2-6,21H,7-10H2,1H3,(H,22,25)(H2,20,31,32)(H,23,24,26,27) JMROEGRSMUVZFK-UHFFFAOYSA-N 360999 3-(2-(Methylsulfonamido)benzo[d]thiazol-4-yl)-6-(piperazin-1-ylsulfonyl)-2-(2H-tetrazol-5-yl)benzenesulfonamide::US10221163, Example 156::US10544130, Example 156 Metallo-beta-lactamase type 2 0.898 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360999 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360999&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311255 386400389 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713362 Nc1nc2cccc(-c3ccc(c(c3-c3nn[nH]n3)S(N)(=O)=O)S(=O)(=O)N3CCNCC3)c2[nH]1 InChI=1S/C18H20N10O4S2/c19-18-22-12-3-1-2-11(15(12)23-18)10-4-5-13(34(31,32)28-8-6-21-7-9-28)16(33(20,29)30)14(10)17-24-26-27-25-17/h1-5,21H,6-9H2,(H3,19,22,23)(H2,20,29,30)(H,24,25,26,27) DRKUCVWOBRAQJJ-UHFFFAOYSA-N 361000 3-(2-amino-3H-benzo[d]imidazol-4-yl)-6-(piperazin-1-ylsulfonyl)-2-(2H-tetrazol-5-yl)benzenesulfonamide::US10221163, Example 157::US10544130, Example 157 Metallo-beta-lactamase type 2 3.09 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361000 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361000&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124158233 386400390 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 714103 NCC(CN)NS(=O)(=O)c1ccc(-c2ccc(N)nc2)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C15H20N10O4S2/c16-5-9(6-17)23-31(28,29)11-3-2-10(8-1-4-12(18)20-7-8)13(14(11)30(19,26)27)15-21-24-25-22-15/h1-4,7,9,23H,5-6,16-17H2,(H2,18,20)(H2,19,26,27)(H,21,22,24,25) XONJRNLITDZUPT-UHFFFAOYSA-N 361247 US10221163, Example 404::US10544130, Example 404 Metallo-beta-lactamase type 2 0.354 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361247 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361247&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 137537526 386400636 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 714106 NCC(CN)NS(=O)(=O)c1ccc(-c2ccnc(N)c2)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C15H20N10O4S2/c16-6-9(7-17)23-31(28,29)11-2-1-10(8-3-4-20-12(18)5-8)13(14(11)30(19,26)27)15-21-24-25-22-15/h1-5,9,23H,6-7,16-17H2,(H2,18,20)(H2,19,26,27)(H,21,22,24,25) JWVIACWDXBAAGB-UHFFFAOYSA-N 361248 US10221163, Example 405::US10544130, Example 405 Metallo-beta-lactamase type 2 17.9 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361248 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361248&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 137537711 386400637 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 714109 NCC(CN)NS(=O)(=O)c1ccc(-c2ccc3nccn3c2)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C17H20N10O4S2/c18-7-11(8-19)24-33(30,31)13-3-2-12(10-1-4-14-21-5-6-27(14)9-10)15(16(13)32(20,28)29)17-22-25-26-23-17/h1-6,9,11,24H,7-8,18-19H2,(H2,20,28,29)(H,22,23,25,26) HEXNYHIYGROCAJ-UHFFFAOYSA-N 361249 US10221163, Example 406::US10544130, Example 406 Metallo-beta-lactamase type 2 0.592 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361249 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361249&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 137537625 386400638 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 714112 NC[C@H](CO)NS(=O)(=O)c1ccc(-c2cccc3[nH]nnc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C16H16N10O5S2/c17-6-8(7-27)23-33(30,31)12-5-4-9(10-2-1-3-11-14(10)20-24-19-11)13(15(12)32(18,28)29)16-21-25-26-22-16/h1-5,8,23,27H,6-7,17H2,(H2,18,28,29)/b10-9+/t8-/m1/s1 BSOALSPTRJCYFY-KGSKPCQNSA-N 361250 US10221163, Example 407::US10544130, Example 407 Metallo-beta-lactamase type 2 1.35 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361250 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361250&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 137537614 386400639 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 714115 NC[C@H](CO)NS(=O)(=O)c1ccc(-c2ccc(N)nc2)c(-c2nn[nH]n2)c1S(N)(=O)=O 361251 US10221163, Example 408::US10544130, Example 408 Metallo-beta-lactamase type 2 0.684 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361251 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361251&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 137537599 386400640 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 714118 NC[C@@H](CO)NS(=O)(=O)c1ccc(-c2ccc(N)nc2)c(-c2nn[nH]n2)c1S(N)(=O)=O 361252 US10221163, Example 409::US10544130, Example 409 Metallo-beta-lactamase type 2 0.170 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361252 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361252&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 137537557 386400641 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 714121 Nc1ccc(cn1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)N[C@H]1CNC[C@H]1O 361253 US10221163, Example 410::US10544130, Example 410 Metallo-beta-lactamase type 2 0.681 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361253 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361253&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 137537698 386400642 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 714124 Nc1ccc(cn1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)N[C@H]1CN[C@H](CO)C1 361254 US10221163, Example 411::US10544130, Example 411 Metallo-beta-lactamase type 2 0.408 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361254 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361254&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 137537607 386400643 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 714127 NS(=O)(=O)c1c(ccc(-c2cccc3[nH]nnc23)c1-c1nn[nH]n1)S(=O)(=O)N[C@@H]1CNC[C@@H]1O InChI=1S/C17H16N10O5S2/c18-33(29,30)16-13(34(31,32)24-11-6-19-7-12(11)28)5-4-8(14(16)17-22-26-27-23-17)9-2-1-3-10-15(9)21-25-20-10/h1-5,11-12,19,24,28H,6-7H2,(H2,18,29,30)/b9-8+/t11-,12+/m1/s1 YGUFCTKAWQOGPA-DGTDAXKGSA-N 361255 US10221163, Example 412::US10544130, Example 412 Metallo-beta-lactamase type 2 2.57 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361255 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361255&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 137537561 386400644 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 714130 N[C@@H]1CNC[C@@H]1NS(=O)(=O)c1ccc(-c2ccc(N)nc2)c(-c2nn[nH]n2)c1S(N)(=O)=O 361256 US10221163, Example 413::US10544130, Example 413 Metallo-beta-lactamase type 2 0.800 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361256 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361256&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 137537608 386400645 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 714133 N[C@H]1CNCC1NS(=O)(=O)c1ccc(-c2ccc(N)nc2)c(-c2nn[nH]n2)c1S(N)(=O)=O 361257 US10221163, Example 414 Metallo-beta-lactamase type 2 0.786 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361257 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361257&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 137537705 386400646 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 714136 NC[C@H](N)CNS(=O)(=O)c1ccc(-c2ccc(N)nc2)c(-c2nn[nH]n2)c1S(N)(=O)=O 361258 US10221163, Example 415::US10544130, Example 415 Metallo-beta-lactamase type 2 0.801 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361258 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361258&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 137537591 386400647 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 714139 NC[C@@H](N)CNS(=O)(=O)c1ccc(-c2ccc(N)nc2)c(-c2nn[nH]n2)c1S(N)(=O)=O 361259 US10221163, Example 416::US10544130, Example 416 Metallo-beta-lactamase type 2 1.34 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361259 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361259&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 137537592 386400648 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 714142 NC[C@H](N)CNS(=O)(=O)c1ccc(-c2ccnc(N)c2)c(-c2nn[nH]n2)c1S(N)(=O)=O 361260 US10221163, Example 417 Metallo-beta-lactamase type 2 1.28 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361260 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361260&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 137537718 386400649 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 714145 NC[C@H](O)CNS(=O)(=O)c1ccc(-c2ccc3nccn3c2)c(-c2nn[nH]n2)c1S(N)(=O)=O 361261 US10221163, Example 418::US10544130, Example 418 Metallo-beta-lactamase type 2 0.834 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361261 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361261&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 137537719 386400650 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 714148 NC[C@@H](O)CNS(=O)(=O)c1ccc(-c2ccnc(N)c2)c(-c2nn[nH]n2)c1S(N)(=O)=O 361262 US10221163, Example 419::US10544130, Example 419 Metallo-beta-lactamase type 2 1.51 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361262 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361262&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 137537606 386400651 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 714151 NC[C@@H](O)CNS(=O)(=O)c1ccc(-c2ccc3nccn3c2)c(-c2nn[nH]n2)c1S(N)(=O)=O 361263 US10221163, Example 420::US10544130, Example 420 Metallo-beta-lactamase type 2 0.974 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361263 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361263&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 137537530 386400652 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 714154 C[C@H](N)CNS(=O)(=O)c1ccc(-c2ccnc(N)c2)c(-c2nn[nH]n2)c1S(N)(=O)=O 361264 US10221163, Example 421::US10544130, Example 421 Metallo-beta-lactamase type 2 1.14 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361264 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361264&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 137537528 386400653 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 714157 C[C@@H](N)CNS(=O)(=O)c1ccc(-c2ccnc(N)c2)c(-c2nn[nH]n2)c1S(N)(=O)=O 361265 US10221163, Example 422::US10544130, Example 422 Metallo-beta-lactamase type 2 0.982 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361265 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361265&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 137537609 386400654 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 714160 C[C@@H](N)CNS(=O)(=O)c1ccc(-c2ccc3nccn3c2)c(-c2nn[nH]n2)c1S(N)(=O)=O 361266 US10221163, Example 423::US10544130, Example 423 Metallo-beta-lactamase type 2 1.15 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361266 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361266&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 137537532 386400655 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713365 Cn1c(N)nc2c(cccc12)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)N1CCNCC1 InChI=1S/C19H22N10O4S2/c1-28-13-4-2-3-12(16(13)23-19(28)20)11-5-6-14(35(32,33)29-9-7-22-8-10-29)17(34(21,30)31)15(11)18-24-26-27-25-18/h2-6,22H,7-10H2,1H3,(H2,20,23)(H2,21,30,31)(H,24,25,26,27) QDKBOVSCISEIKW-UHFFFAOYSA-N 361001 3-(2-amino-1-methyl-1H- benzo[d]imidazol-4-yl)-6- (piperazin-1-ylsulfonyl)-2- (2H-tetrazol-5- yl)benzenesulfonamide::US10221163, Example 158::US10544130, Example 158 Metallo-beta-lactamase type 2 1.71 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361001 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361001&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311055 386400391 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713368 Nc1nc2c(cccc2o1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)N1CCNCC1 InChI=1S/C18H19N9O5S2/c19-18-22-15-11(2-1-3-12(15)32-18)10-4-5-13(34(30,31)27-8-6-21-7-9-27)16(33(20,28)29)14(10)17-23-25-26-24-17/h1-5,21H,6-9H2,(H2,19,22)(H2,20,28,29)(H,23,24,25,26) YFZRDNDRLVDZJA-UHFFFAOYSA-N 361002 3-(2-aminobenzo[d]oxazol-4- yl)-6-(piperazin-1-ylsulfonyl)- 2-(2H-tetrazol-5- yl)benzenesulfonamide::US10221163, Example 159::US10544130, Example 159 Metallo-beta-lactamase type 2 1.29 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361002 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361002&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311817 386400392 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713371 NS(=O)(=O)c1c(ccc(-c2cccc3cn[nH]c23)c1-c1nnn[nH]1)S(=O)(=O)N1CCNCC1 InChI=1S/C18H19N9O4S2/c19-32(28,29)17-14(33(30,31)27-8-6-20-7-9-27)5-4-12(15(17)18-23-25-26-24-18)13-3-1-2-11-10-21-22-16(11)13/h1-5,10,20H,6-9H2,(H,21,22)(H2,19,28,29)(H,23,24,25,26) UMBJQXVDZMLNAG-UHFFFAOYSA-N 361003 3-(1H-indazol-7-yl)-6- (piperazin-1-ylsulfonyl)-2- (1H-tetrazol-5- yl)benzenesulfonamide::US10221163, Example 160::US10544130, Example 160 Metallo-beta-lactamase type 2 1.39 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361003 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361003&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135310816 386400393 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713374 Nc1nc2c(cccc2[nH]1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)NC1CCNC1 InChI=1S/C18H18N10O4S2/c19-18-22-12-3-1-2-11(15(12)23-18)10-4-5-13(34(31,32)26-9-6-7-21-8-9)16(33(20,29)30)14(10)17-24-27-28-25-17/h1-5,9,21,26H,6-8H2,(H2,19,22)(H2,20,29,30)/b11-10+ NLYPTRFLEOKOAY-ZHACJKMWSA-N 361004 4-(2-amino-1H-benzo[d]imidazol-4-yl)-N1—((R)-pyrrolidin-3-yl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 161::US10544130, Example 161 Metallo-beta-lactamase type 2 0.401 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361004 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361004&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135310679 386400394 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713377 Nc1nc2c(cccc2[nH]1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)N[C@H]1CCNC1 InChI=1S/C18H18N10O4S2/c19-18-22-12-3-1-2-11(15(12)23-18)10-4-5-13(34(31,32)26-9-6-7-21-8-9)16(33(20,29)30)14(10)17-24-27-28-25-17/h1-5,9,21,26H,6-8H2,(H2,19,22)(H2,20,29,30)/b11-10+/t9-/m0/s1 NLYPTRFLEOKOAY-YHTNPHCKSA-N 361005 4-(2-amino-1H- benzo[d]imidazol-4-yl)-N1-((S)- pyrrolidin-3-yl)-3-(2H-tetrazol- 5-yl)benzene-1,2-disulfonamide::US10221163, Example 162::US10544130, Example 162 Metallo-beta-lactamase type 2 0.733 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361005 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361005&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311798 386400395 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713380 Cn1c(N)nc2c(cccc12)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)N[C@H]1CCNC1 361006 4-(2-amino-1-methyl-1H- benzo[d]imidazol-4-yl)-N1-((S)- pyrrolidin-3-yl)-3-(2H-tetrazol- 5-yl)benzene-1,2-disulfonamide::US10221163, Example 163::US10544130, Example 163 Metallo-beta-lactamase type 2 0.450 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361006 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361006&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311949 386400396 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713383 Cn1c(N)nc2c(cccc12)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)N[C@@H]1CCNC1 361007 4-(2-amino-1-methyl-1H- benzo[d]imidazol-4-yl)-N1-((R)- pyrrolidin-3-yl)-3-(2H-tetrazol- 5-yl)benzene-1,2-disulfonamide::US10221163, Example 164::US10544130, Example 164 Metallo-beta-lactamase type 2 0.272 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361007 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361007&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311980 386400397 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713386 NC1CCC(CC1)c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(N)(=O)=O InChI=1S/C13H19N7O4S2/c14-8-3-1-7(2-4-8)9-5-6-10(25(15,21)22)12(26(16,23)24)11(9)13-17-19-20-18-13/h5-8H,1-4,14H2,(H2,15,21,22)(H2,16,23,24)(H,17,18,19,20) UTJPHSHUPFTYLW-UHFFFAOYSA-N 361008 4-(4-aminocyclohexyl)-3-(1H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 165::US10544130, Example 165 Metallo-beta-lactamase type 2 24.4 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361008 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361008&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124159653 386400398 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713389 C[N+]1(C)CC[C@@H](C1)NS(=O)(=O)c1ccc(-c2cccc3[nH]c(N)nc23)c(-c2nn[n-]n2)c1S(N)(=O)=O InChI=1S/C20H24N10O4S2/c1-30(2)9-8-11(10-30)27-36(33,34)15-7-6-12(13-4-3-5-14-17(13)24-20(21)23-14)16(18(15)35(22,31)32)19-25-28-29-26-19/h3-7,11,27H,8-10H2,1-2H3,(H5-,21,22,23,24,25,26,28,29,31,32)/t11-/m0/s1 NWMHLHUOGINKPW-NSHDSACASA-N 361009 (S)-5-(6-(2-amino-1H-benzo[d]imidazol-4-yl)-3-(N-(1,1-dimethylpyrrolidin-1-ium-3-yl)sulfamoyl)-2-sulfamoylphenyl)tetrazol-2-ide::US10221163, Example 166 Metallo-beta-lactamase type 2 0.820 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361009 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361009&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269217 386400399 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713392 Cn1c(N)nc2c(cccc12)-c1ccc(c(c1-c1nn[n-]n1)S(N)(=O)=O)S(=O)(=O)N[C@H]1CC[N+](C)(C)C1 InChI=1S/C21H26N10O4S2/c1-30-15-6-4-5-14(18(15)24-21(30)22)13-7-8-16(37(34,35)27-12-9-10-31(2,3)11-12)19(36(23,32)33)17(13)20-25-28-29-26-20/h4-8,12,27H,9-11H2,1-3H3,(H4-,22,23,24,25,26,28,29,32,33)/t12-/m0/s1 FLEHXFFEXVWGRV-LBPRGKRZSA-N 361010 (S)-5-(6-(2-amino-1-methyl-1H-benzo[d]imidazol-4-yl)-3-(N-(1,1-dimethylpyrrolidin-1-ium-3-yl)sulfamoyl)-2-sulfamoylphenyl)tetrazol-2-ide::US10221163, Example 167::US10544130, Example 167 Metallo-beta-lactamase type 2 0.346 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361010 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361010&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269219 386400400 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713395 Nc1nc2c(cccc2[nH]1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)N[C@H]1CNC[C@H]1O InChI=1S/C18H18N10O5S2/c19-18-22-10-3-1-2-9(15(10)23-18)8-4-5-13(35(32,33)26-11-6-21-7-12(11)29)16(34(20,30)31)14(8)17-24-27-28-25-17/h1-5,11-12,21,26,29H,6-7H2,(H2,19,22)(H2,20,30,31)/b9-8+/t11-,12+/m0/s1 KQMMMLLEOPMFOS-VDTGWRSZSA-N 361011 4-(2-amino-1H-benzo[d]imidazol-4-yl)-N1-(3S,4R)-4-hydroxypyrrolidin-3-yl)-3-(1H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 168::US10544130, Example 168 Metallo-beta-lactamase type 2 0.544 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361011 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361011&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124159594 386400401 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713398 Nc1nc2c(cccc2[nH]1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)N[C@H]1CNC[C@@H]1O InChI=1S/C18H18N10O5S2/c19-18-22-10-3-1-2-9(15(10)23-18)8-4-5-13(35(32,33)26-11-6-21-7-12(11)29)16(34(20,30)31)14(8)17-24-27-28-25-17/h1-5,11-12,21,26,29H,6-7H2,(H2,19,22)(H2,20,30,31)/b9-8-/t11-,12-/m0/s1 KQMMMLLEOPMFOS-RTVKQWPZSA-N 361012 4-(2-amino-1H- benzo[d]imidazol-4-yl)-N1- ((3S,4S)-4-hydroxypyrrolidin-3- yl)-3-(1H-tetrazol-5- yl)benzene-1,2-disulfonamide::US10221163, Example 169::US10544130, Example 169 Metallo-beta-lactamase type 2 2.08 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361012 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361012&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311791 386400402 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713401 Nc1nc2c(cccc2[nH]1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)N[C@@H]1CNC[C@@H]1O InChI=1S/C18H18N10O5S2/c19-18-22-10-3-1-2-9(15(10)23-18)8-4-5-13(35(32,33)26-11-6-21-7-12(11)29)16(34(20,30)31)14(8)17-24-27-28-25-17/h1-5,11-12,21,26,29H,6-7H2,(H2,19,22)(H2,20,30,31)/b9-8-/t11-,12+/m1/s1 KQMMMLLEOPMFOS-STNFYNBXSA-N 361013 4-(2-amino-1H- benzo[d]imidazol-4-yl)-N1- ((3R,4S)-4-hydroxypyrrolidin- 3-yl)-3-(1H-tetrazol-5- yl)benzene-1,2-disulfonamide::US10221163, Example 170::US10544130, Example 170 Metallo-beta-lactamase type 2 1.12 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361013 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361013&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135310942 386400403 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713404 Nc1nc2c(cccc2[nH]1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)N[C@@H]1CNC[C@H]1O InChI=1S/C18H18N10O5S2/c19-18-22-10-3-1-2-9(15(10)23-18)8-4-5-13(35(32,33)26-11-6-21-7-12(11)29)16(34(20,30)31)14(8)17-24-27-28-25-17/h1-5,11-12,21,26,29H,6-7H2,(H2,19,22)(H2,20,30,31)/b9-8-/t11-,12-/m1/s1 KQMMMLLEOPMFOS-DSWQZHNZSA-N 361014 4-(2-amino-1H- benzo[d]imidazol-4-yl)-N1- ((3R,4R)-4-hydroxypyrrolidin- 3-yl)-3-(1H-tetrazol-5- yl)benzene-1,2-disulfonamide::US10221163, Example 171::US10544130, Example 171 Metallo-beta-lactamase type 2 1.39 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361014 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361014&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311865 386400404 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713407 Nc1nc2c(cccc2[nH]1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)N[C@H]1CN[C@H](CO)C1 InChI=1S/C19H20N10O5S2/c20-19-23-13-3-1-2-12(16(13)24-19)11-4-5-14(36(33,34)27-9-6-10(8-30)22-7-9)17(35(21,31)32)15(11)18-25-28-29-26-18/h1-5,9-10,22,27,30H,6-8H2,(H2,20,23)(H2,21,31,32)/b12-11-/t9-,10+/m1/s1 WQRBNQMLJQOESH-VYEBIXSXSA-N 361015 4-(2-amino-1H- benzo[d]imidazol-4-yl)-N1- ((3R,5S)-5- (hydroxymethyl)pyrrolidin-3- yl)-3-(1H-tetrazol-5- yl)benzene-1,2-disulfonamide::US10221163, Example 172::US10544130, Example 172 Metallo-beta-lactamase type 2 0.509 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361015 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361015&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311287 386400405 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713410 Nc1nc2c(cccc2[nH]1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)N[C@H]1CN[C@@H](CO)C1 InChI=1S/C19H20N10O5S2/c20-19-23-13-3-1-2-12(16(13)24-19)11-4-5-14(36(33,34)27-9-6-10(8-30)22-7-9)17(35(21,31)32)15(11)18-25-28-29-26-18/h1-5,9-10,22,27,30H,6-8H2,(H2,20,23)(H2,21,31,32)/b12-11-/t9-,10-/m1/s1 WQRBNQMLJQOESH-WNPRHHQDSA-N 361016 4-(2-amino-1H- benzo[d]imidazol-4-yl)-N1- ((3R,5R)-5- (hydroxymethyl)pyrrolidin-3- yl)-3-(1H-tetrazol-5- yl)benzene-1,2-disulfonamide::US10221163, Example 173::US10544130, Example 173 Metallo-beta-lactamase type 2 0.933 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361016 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361016&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135310673 386400406 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713413 Nc1nc2c(cccc2[nH]1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)N[C@@H]1CN[C@@H](CO)C1 InChI=1S/C19H20N10O5S2/c20-19-23-13-3-1-2-12(16(13)24-19)11-4-5-14(36(33,34)27-9-6-10(8-30)22-7-9)17(35(21,31)32)15(11)18-25-28-29-26-18/h1-5,9-10,22,27,30H,6-8H2,(H2,20,23)(H2,21,31,32)/b12-11-/t9-,10+/m0/s1 WQRBNQMLJQOESH-FQHHDQPRSA-N 361017 4-(2-amino-1H- benzo[d]imidazol-4-yl)-N1- ((3S,5R)-5- (hydroxymethyl)pyrrolidin-3- yl)-3-(1H-tetrazol-5- yl)benzene-1,2-disulfonamide::US10221163, Example 174::US10544130, Example 174 Metallo-beta-lactamase type 2 1.66 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361017 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361017&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311033 386400407 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713416 Nc1nc2c(cccc2[nH]1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)N[C@@H]1CN[C@H](CO)C1 InChI=1S/C19H20N10O5S2/c20-19-23-13-3-1-2-12(16(13)24-19)11-4-5-14(36(33,34)27-9-6-10(8-30)22-7-9)17(35(21,31)32)15(11)18-25-28-29-26-18/h1-5,9-10,22,27,30H,6-8H2,(H2,20,23)(H2,21,31,32)/b12-11-/t9-,10-/m0/s1 WQRBNQMLJQOESH-DDSNRYIPSA-N 361018 4-(2-amino-1H- benzo[d]imidazol-4-yl)-N1- ((3S,5S)-5- (hydroxymethyl)pyrrolidin-3- yl)-3-(1H-tetrazol-5- yl)benzene-1,2-disulfonamide::US10221163, Example 175::US10544130, Example 175 Metallo-beta-lactamase type 2 1.00 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361018 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361018&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311440 386400408 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713419 Nc1nc2c(cccc2[nH]1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)N[C@@]1(CO)CCNC1 InChI=1S/C19H20N10O5S2/c20-18-23-12-3-1-2-11(15(12)24-18)10-4-5-13(36(33,34)27-19(9-30)6-7-22-8-19)16(35(21,31)32)14(10)17-25-28-29-26-17/h1-5,22,27,30H,6-9H2,(H2,20,23)(H2,21,31,32)/b11-10-/t19-/m0/s1 WPMCUEUBPIRDFI-GDWUOILNSA-N 361019 (S)-4-(2-amino-1H- benzo[d]imidazol-4-yl)-N1-(3- (hydroxymethyl)pyrrolidin-3- yl)-3-(1H-tetrazol-5- yl)benzene-1,2-disulfonamide::US10221163, Example 176::US10544130, Example 176 Metallo-beta-lactamase type 2 0.728 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361019 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361019&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311531 386400409 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713422 Nc1nc2c(cccc2[nH]1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)N[C@]1(CO)CCNC1 InChI=1S/C19H20N10O5S2/c20-18-23-12-3-1-2-11(15(12)24-18)10-4-5-13(36(33,34)27-19(9-30)6-7-22-8-19)16(35(21,31)32)14(10)17-25-28-29-26-17/h1-5,22,27,30H,6-9H2,(H2,20,23)(H2,21,31,32)/b11-10-/t19-/m1/s1 WPMCUEUBPIRDFI-OEIFXAAASA-N 361020 (R)-4-(2-amino-1H- benzo[d]imidazol-4-yl)-N1-(3- (hydroxymethyl)pyrrolidin-3- yl)-3-(1H-tetrazol-5- yl)benzene-1,2-disulfonamide::US10221163, Example 177::US10544130, Example 177 Metallo-beta-lactamase type 2 0.862 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361020 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361020&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311396 386400410 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 714163 N[C@@H]1CNC[C@H]1NS(=O)(=O)c1ccc(-c2cccc3[nH]c(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C18H19N11O4S2/c19-10-6-22-7-12(10)27-35(32,33)13-5-4-8(9-2-1-3-11-15(9)24-18(20)23-11)14(16(13)34(21,30)31)17-25-28-29-26-17/h1-5,10,12,22,27H,6-7,19H2,(H2,20,23)(H2,21,30,31)/b9-8+/t10-,12-/m1/s1 LIRUKQKKERNVIK-VCXMCINHSA-N 361165 4-(2-Amino-1H-benzo[d]imidazol-4-yl)-N1-((3S,4R)-4-aminopyrrolidin-3-yl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 322::US10221163, Example 424::US10544130, Example 424 Metallo-beta-lactamase type 2 0.814 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361165 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361165&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269246 386400555 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 714166 NC[C@@H]1C[C@H](CN1)NS(=O)(=O)c1ccc(-c2cccc3[nH]c(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C19H21N11O4S2/c20-7-9-6-10(8-23-9)28-36(33,34)14-5-4-11(12-2-1-3-13-16(12)25-19(21)24-13)15(17(14)35(22,31)32)18-26-29-30-27-18/h1-5,9-10,23,28H,6-8,20H2,(H2,21,24)(H2,22,31,32)/b12-11+/t9-,10+/m0/s1 KTMUYXQVZSGHIU-XXQWGACESA-N 361268 4-(2-amino-1H-benzo[d]imidazol-4-yl)-N1-((3R,5S)-5-(aminomethyl)pyrrolidin-3-yl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 425::US10544130, Example 425 Metallo-beta-lactamase type 2 0.886 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361268 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361268&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311876 386400656 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 714169 NCC(CO)NS(=O)(=O)c1ccc(-c2cccc3[nH]c(N)nc23)c(-c2nnn[nH]2)c1S(N)(=O)=O InChI=1S/C17H18N10O5S2/c18-6-8(7-28)25-34(31,32)12-5-4-9(10-2-1-3-11-14(10)22-17(19)21-11)13(15(12)33(20,29)30)16-23-26-27-24-16/h1-5,8,25,28H,6-7,18H2,(H2,19,21)(H2,20,29,30)/b10-9+ KAGPCWFBBKVWMA-MDZDMXLPSA-N 361269 (S)-4-(2-Amino-1H-benzo[d]imidazol-4-yl)-N1-(1-amino-3-hydroxypropan-2-yl)-3-(1H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 426::US10544130, Example 426 Metallo-beta-lactamase type 2 0.273 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361269 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361269&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269285 386400657 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 714172 NC[C@H](CO)NS(=O)(=O)c1ccc(-c2cccc3nc(N)[nH]c23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C17H18N10O5S2/c18-6-8(7-28)25-34(31,32)12-5-4-9(10-2-1-3-11-14(10)22-17(19)21-11)13(15(12)33(20,29)30)16-23-26-27-24-16/h1-5,8,25,28H,6-7,18H2,(H2,19,21)(H2,20,29,30)/b10-9+/t8-/m1/s1 KAGPCWFBBKVWMA-KGSKPCQNSA-N 361270 US10221163, Example 427::US10544130, Example 427 Metallo-beta-lactamase type 2 2.61 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361270 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361270&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 137537601 386400658 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 714175 Nc1nc(c[nH]1)-c1cccc(c1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)N[C@@H]1CCNC1 361271 US10221163, Example 428::US10544130, Example 428 Metallo-beta-lactamase type 2 0.407 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361271 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361271&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269286 386400659 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 714178 NCC(CN)NS(=O)(=O)c1ccc(-c2cccc3[nH]c(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C17H21N11O4S2/c18-6-8(7-19)26-34(31,32)12-5-4-9(10-2-1-3-11-14(10)23-17(20)22-11)13(15(12)33(21,29)30)16-24-27-28-25-16/h1-5,8,26H,6-7,18-19H2,(H3,20,22,23)(H2,21,29,30)(H,24,25,27,28) CXSKGFQNMGEJNL-UHFFFAOYSA-N 361272 US10221163, Example 429::US10544130, Example 429 Metallo-beta-lactamase type 2 0.489 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361272 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361272&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 137537628 386400660 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 714181 NCC(CN)NS(=O)(=O)c1ccc(-c2cccc3ccc(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C19H22N10O4S2/c20-8-11(9-21)27-35(32,33)14-6-5-12(13-3-1-2-10-4-7-15(22)24-17(10)13)16(18(14)34(23,30)31)19-25-28-29-26-19/h1-7,11,27H,8-9,20-21H2,(H2,22,24)(H2,23,30,31)(H,25,26,28,29) CLEQRMCQLNNGRY-UHFFFAOYSA-N 361273 US10221163, Example 430::US10544130, Example 430 Metallo-beta-lactamase type 2 0.102 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361273 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361273&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 137537716 386400661 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 714184 CCOC(=O)c1sc(N)nc1-c1cccc(c1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)NC(CN)CN InChI=1S/C22H26N10O6S3/c1-2-38-21(33)18-17(27-22(25)39-18)12-5-3-4-11(8-12)14-6-7-15(41(36,37)30-13(9-23)10-24)19(40(26,34)35)16(14)20-28-31-32-29-20/h3-8,13,30H,2,9-10,23-24H2,1H3,(H2,25,27)(H2,26,34,35)(H,28,29,31,32) JKAOOUXUHVNVNM-UHFFFAOYSA-N 361274 US10221163, Example 431::US10544130, Example 431 Metallo-beta-lactamase type 2 0.133 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361274 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361274&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 137537604 386400662 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 714187 NCc1sc(N)nc1-c1cccc(c1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)N[C@@H]1CCNC1 361275 US10221163, Example 432::US10544130, Example 432 Metallo-beta-lactamase type 2 1.52 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361275 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361275&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 137537605 386400663 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 714190 NCCNCc1sc(N)nc1-c1cccc(c1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)N[C@@H]1CCNC1 361276 US10221163, Example 433::US10544130, Example 433 Metallo-beta-lactamase type 2 1.33 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361276 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361276&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 137537735 386400664 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 714193 NC[C@H](N)CNS(=O)(=O)c1ccc(-c2cccc(c2)-c2c[nH]c(N)n2)c(-c2nn[nH]n2)c1S(N)(=O)=O 361277 US10221163, Example 434::US10544130, Example 434 Metallo-beta-lactamase type 2 1.53 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361277 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361277&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269287 386400665 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 714196 NCC(CN)NS(=O)(=O)c1ccc(-c2cccc(c2)-c2c[nH]c(N)n2)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C19H23N11O4S2/c20-7-12(8-21)28-36(33,34)15-5-4-13(16(17(15)35(23,31)32)18-26-29-30-27-18)10-2-1-3-11(6-10)14-9-24-19(22)25-14/h1-6,9,12,28H,7-8,20-21H2,(H3,22,24,25)(H2,23,31,32)(H,26,27,29,30) ANTMOAIWXABXQH-UHFFFAOYSA-N 361278 US10221163, Example 435::US10544130, Example 435 Metallo-beta-lactamase type 2 1.78 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361278 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361278&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 137537598 386400666 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 714199 NCC(CN)NS(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C17H20N10O4S3/c18-6-8(7-19)25-34(30,31)12-5-4-9(10-2-1-3-11-14(10)22-17(20)32-11)13(15(12)33(21,28)29)16-23-26-27-24-16/h1-5,8,25H,6-7,18-19H2,(H2,20,22)(H2,21,28,29)(H,23,24,26,27) HLXWUESRDMZWKV-UHFFFAOYSA-N 361279 US10221163, Example 436::US10544130, Example 436 Metallo-beta-lactamase type 2 0.103 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361279 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361279&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 137537544 386400667 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 714202 NCC(CN)NS(=O)(=O)c1ccc(-c2ccnc(c2)-c2cnc(N)[nH]2)c(-c2nnn[nH]2)c1S(N)(=O)=O InChI=1S/C18H22N12O4S2/c19-6-10(7-20)28-36(33,34)14-2-1-11(15(16(14)35(22,31)32)17-26-29-30-27-17)9-3-4-23-12(5-9)13-8-24-18(21)25-13/h1-5,8,10,28H,6-7,19-20H2,(H3,21,24,25)(H2,22,31,32)(H,26,27,29,30) NGXJGSGMLDIREA-UHFFFAOYSA-N 361280 4-(2-(2-Amino-1H-imidazol-5-yl)pyridin-4-yl)-N1-(1,3-diaminopropan-2-yl)-3-(1H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 437::US10544130, Example 437 Metallo-beta-lactamase type 2 2.41 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361280 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361280&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269288 386400668 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 714205 NCC(CN)NS(=O)(=O)c1ccc(-c2cccc(n2)-c2cnc(N)[nH]2)c(-c2nnn[nH]2)c1S(N)(=O)=O InChI=1S/C18H22N12O4S2/c19-6-9(7-20)28-36(33,34)14-5-4-10(15(16(14)35(22,31)32)17-26-29-30-27-17)11-2-1-3-12(24-11)13-8-23-18(21)25-13/h1-5,8-9,28H,6-7,19-20H2,(H3,21,23,25)(H2,22,31,32)(H,26,27,29,30) GQESRYREZHSCIP-UHFFFAOYSA-N 361281 4-(6-(2-Amino-1H-imidazol-5-yl)pyridin-2-yl)-N1-(1,3-diaminopropan-2-yl)-3-(1H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 438::US10544130, Example 438 Metallo-beta-lactamase type 2 17.9 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361281 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361281&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269289 386400669 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 714208 Nc1ncc([nH]1)-c1cccc(n1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)N[C@@H]1CCNC1 361282 (R)-4-(6-(2-Amino-1H-imidazol-5-yl)pyridin-2-yl)-N1-(pyrrolidin-3-yl)-3-(1H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 439::US10544130, Example 439 Metallo-beta-lactamase type 2 6.72 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361282 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361282&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269290 386400670 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 714211 Nc1ncc([nH]1)-c1cc(ccn1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)N[C@@H]1CCNC1 361283 (R)-4-(2-(2-Amino-1H-imidazol-5-yl)pyridin-4-yl)-N1-(pyrrolidin-3-yl)-3-(1H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 440::US10544130, Example 440 Metallo-beta-lactamase type 2 3.96 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361283 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361283&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269291 386400671 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 714214 C[C@H](N)Cc1nc2c(cccc2[nH]1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)N[C@@H]1CCNC1 InChI=1S/C21H24N10O4S2/c1-11(22)9-17-25-15-4-2-3-14(19(15)26-17)13-5-6-16(37(34,35)29-12-7-8-24-10-12)20(36(23,32)33)18(13)21-27-30-31-28-21/h2-6,11-12,24,29H,7-10,22H2,1H3,(H2,23,32,33)/b14-13+/t11-,12+/m0/s1 LSRIGDKBJCCBGW-NSILYDBFSA-N 361284 4-(2-((S)-2-Aminopropyl)-1H-benzo[d]imidazol-4-yl)-N1-((R)-pyrrolidin-3-yl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 441::US10544130, Example 441 Metallo-beta-lactamase type 2 1.23 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361284 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361284&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311546 386400672 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 714217 C[C@H](N)Cc1nc2c(cccc2[nH]1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(N)(=O)=O InChI=1S/C17H17N9O4S2/c1-8(18)7-13-21-11-4-2-3-10(15(11)22-13)9-5-6-12(31(19,27)28)16(32(20,29)30)14(9)17-23-25-26-24-17/h2-6,8H,7,18H2,1H3,(H2,19,27,28)(H2,20,29,30)/b10-9+/t8-/m0/s1 COKRRBMBKGPUFR-VPOJCXOPSA-N 361285 (S)-4-(2-(2-aminopropyl)- 1H-benzo[d]imidazol-4-yl)- 3-(2H-tetrazol-5-yl)benzene- 1,2-disulfonamide::US10221163, Example 442::US10544130, Example 442 Metallo-beta-lactamase type 2 1.33 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361285 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361285&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135310954 386400673 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 714220 NCCNS(=O)(=O)c1ccc(-c2cccc3[nH]c(nc23)C2CNC2)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C19H22N10O4S2/c20-6-7-23-35(32,33)14-5-4-11(15(17(14)34(21,30)31)19-26-28-29-27-19)12-2-1-3-13-16(12)25-18(24-13)10-8-22-9-10/h1-5,10,22-23H,6-9,20H2,(H,24,25)(H2,21,30,31)(H,26,27,28,29) POHULTIMHMVEHW-UHFFFAOYSA-N 361286 N1-(2-aminoethyl)-4-(2- (azetidin-3-yl)-1H- benzo[d]imidazol-4-yl)-3- (2H-tetrazol-5-yl)benzene- 1,2-disulfonamide::US10221163, Example 443::US10544130, Example 443 Metallo-beta-lactamase type 2 0.790 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361286 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361286&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135310886 386400674 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713425 Nc1nc2c(cccc2[nH]1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)N[C@@H]1CCCNC1 InChI=1S/C19H20N10O4S2/c20-19-23-13-5-1-4-12(16(13)24-19)11-6-7-14(35(32,33)27-10-3-2-8-22-9-10)17(34(21,30)31)15(11)18-25-28-29-26-18/h1,4-7,10,22,27H,2-3,8-9H2,(H2,20,23)(H2,21,30,31)/b12-11+/t10-/m1/s1 GTWUEQKXNBYLDY-PJSNMCHCSA-N 361021 (R)-4-(2-amino-1H-benzo[d]imidazol-4-yl)-N1-(piperidin-3-yl)-3-(1H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 178::US10544130, Example 178 Metallo-beta-lactamase type 2 0.870 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361021 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361021&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124159589 386400411 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713428 Nc1nc2c(cccc2[nH]1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)N[C@H]1CCCNC1 InChI=1S/C19H20N10O4S2/c20-19-23-13-5-1-4-12(16(13)24-19)11-6-7-14(35(32,33)27-10-3-2-8-22-9-10)17(34(21,30)31)15(11)18-25-28-29-26-18/h1,4-7,10,22,27H,2-3,8-9H2,(H2,20,23)(H2,21,30,31)/b12-11-/t10-/m0/s1 GTWUEQKXNBYLDY-OQDIYGIBSA-N 361022 (S)-4-(2-amino-1H- benzo[d]imidazol-4-yl)-N1- (piperidin-3-yl)-3-(1H-tetrazol- 5-yl)benzene-1,2-disulfonamide::US10221163, Example 179::US10544130, Example 179 Metallo-beta-lactamase type 2 3.00 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361022 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361022&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311097 386400412 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713431 NCCNS(=O)(=O)c1ccc(-c2cc(F)cc3[nH]c(N)nc23)c(-c2nnn[nH]2)c1S(N)(=O)=O InChI=1S/C16H17FN10O4S2/c17-7-5-9(13-10(6-7)22-16(19)23-13)8-1-2-11(33(30,31)21-4-3-18)14(32(20,28)29)12(8)15-24-26-27-25-15/h1-2,5-6,21H,3-4,18H2,(H3,19,22,23)(H2,20,28,29)(H,24,25,26,27) UELOJMHIIBZDFG-UHFFFAOYSA-N 361023 4-(2-amino-6-fluoro-1H- benzo[d]imidazol-4-yl)-N1-(2- aminoethyl)-3-(1H-tetrazol-5- yl)benzene-1,2-disulfonamide::US10221163, Example 180::US10544130, Example 180 Metallo-beta-lactamase type 2 0.387 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361023 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361023&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311708 386400413 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713434 Nc1nc2c(cc(F)cc2[nH]1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)N[C@@H]1CCNC1 InChI=1S/C18H17FN10O4S2/c19-8-5-11(15-12(6-8)23-18(20)24-15)10-1-2-13(35(32,33)27-9-3-4-22-7-9)16(34(21,30)31)14(10)17-25-28-29-26-17/h1-2,5-6,9,22,27H,3-4,7H2,(H2,20,23)(H2,21,30,31)/b11-10+/t9-/m1/s1 SXTBYHWGGXCMBX-HNLKAFMCSA-N 361024 (R)-4-(2-amino-6-fluoro-1H- benzo[d]imidazol-4-yl)-N1- (pyrrolidin-3-yl)-3-(1H-tetrazol- 5-yl)benzene-1,2-disulfonamide::US10221163, Example 181::US10544130, Example 181 Metallo-beta-lactamase type 2 0.273 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361024 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361024&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311336 386400414 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713437 NCCCNS(=O)(=O)c1ccc(-c2cccc3[nH]c(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C17H20N10O4S2/c18-7-2-8-21-33(30,31)12-6-5-9(10-3-1-4-11-14(10)23-17(19)22-11)13(15(12)32(20,28)29)16-24-26-27-25-16/h1,3-6,21H,2,7-8,18H2,(H3,19,22,23)(H2,20,28,29)(H,24,25,26,27) BFOYHAUOQCJINB-UHFFFAOYSA-N 361025 4-(2-amino-1H-benzo[d]imidazol-4-yl)-N1-(3-aminopropyl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 182::US10544130, Example 182 Metallo-beta-lactamase type 2 0.453 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361025 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361025&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124159615 386400415 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713440 Cn1c(N)nc2c(cccc12)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)NCCCN InChI=1S/C18H22N10O4S2/c1-28-12-5-2-4-11(15(12)23-18(28)20)10-6-7-13(34(31,32)22-9-3-8-19)16(33(21,29)30)14(10)17-24-26-27-25-17/h2,4-7,22H,3,8-9,19H2,1H3,(H2,20,23)(H2,21,29,30)(H,24,25,26,27) UBSHWFYWCAQXGO-UHFFFAOYSA-N 361026 4-(2-amino-1-methyl-1H-benzo[d]imidazol-4-yl)-N1-(3-aminopropyl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 183::US10544130, Example 183 Metallo-beta-lactamase type 2 0.338 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361026 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361026&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124159607 386400416 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713443 C[C@H](N)CNS(=O)(=O)c1ccc(-c2cccc3[nH]c(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C17H18N10O4S2/c1-8(18)7-21-33(30,31)12-6-5-9(10-3-2-4-11-14(10)23-17(19)22-11)13(15(12)32(20,28)29)16-24-26-27-25-16/h2-6,8,21H,7,18H2,1H3,(H2,19,22)(H2,20,28,29)/b10-9+/t8-/m0/s1 BZRATMYQIUECIG-VPOJCXOPSA-N 361027 4-(2-amino-1H-benzo[d]imidazol-4-yl)-N1-((S)-2-aminopropyl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 184::US10544130, Example 184 Metallo-beta-lactamase type 2 0.673 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361027 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361027&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124159687 386400417 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713446 C[C@@H](N)CNS(=O)(=O)c1ccc(-c2cccc3[nH]c(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C17H18N10O4S2/c1-8(18)7-21-33(30,31)12-6-5-9(10-3-2-4-11-14(10)23-17(19)22-11)13(15(12)32(20,28)29)16-24-26-27-25-16/h2-6,8,21H,7,18H2,1H3,(H2,19,22)(H2,20,28,29)/b10-9+/t8-/m1/s1 BZRATMYQIUECIG-KGSKPCQNSA-N 361028 4-(2-amino-1H-benzo[d]imidazol-4-yl)-N1-((R)-2-aminopropyl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 185::US10544130, Example 185 Metallo-beta-lactamase type 2 0.524 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361028 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361028&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124159698 386400418 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713449 C[C@@H](CN)NS(=O)(=O)c1ccc(-c2cccc3[nH]c(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C17H18N10O4S2/c1-8(7-18)25-33(30,31)12-6-5-9(10-3-2-4-11-14(10)22-17(19)21-11)13(15(12)32(20,28)29)16-23-26-27-24-16/h2-6,8,25H,7,18H2,1H3,(H2,19,21)(H2,20,28,29)/b10-9+/t8-/m0/s1 WQHJTRWTMBJTIA-VPOJCXOPSA-N 361029 4-(2-amino-1H-benzo[d]imidazol-4-yl)-N1—(S)-1-aminopropan-2-yl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 186::US10544130, Example 186 Metallo-beta-lactamase type 2 4.09 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361029 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361029&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124159632 386400419 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713452 C[C@H](CN)NS(=O)(=O)c1ccc(-c2cccc3[nH]c(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C17H18N10O4S2/c1-8(7-18)25-33(30,31)12-6-5-9(10-3-2-4-11-14(10)22-17(19)21-11)13(15(12)32(20,28)29)16-23-26-27-24-16/h2-6,8,25H,7,18H2,1H3,(H2,19,21)(H2,20,28,29)/b10-9+/t8-/m1/s1 WQHJTRWTMBJTIA-KGSKPCQNSA-N 361030 4-(2-amino-1H-benzo[d]imidazol-4-yl)-N1—((R)-1-aminopropan-2-yl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 187::US10544130, Example 187 Metallo-beta-lactamase type 2 0.230 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361030 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361030&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124159697 386400420 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713455 N[C@H](CNS(=O)(=O)c1ccc(-c2cccc3[nH]c(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O)C(N)=O InChI=1S/C17H17N11O5S2/c18-9(15(19)29)6-22-35(32,33)11-5-4-7(8-2-1-3-10-13(8)24-17(20)23-10)12(14(11)34(21,30)31)16-25-27-28-26-16/h1-5,9,22H,6,18H2,(H2,19,29)(H2,20,23)(H2,21,30,31)/b8-7+/t9-/m1/s1 HEBMKFORMCSKAU-FCZSHJHJSA-N 361031 (2R)-2-amino-3-(4-(2-amino-1H-benzo[d]imidazol-4-yl)-2-sulfamoyl-3-(2H-tetrazol-5-yl)phenylsulfonamido)propanamide::US10221163, Example 188::US10544130, Example 188 Metallo-beta-lactamase type 2 0.613 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361031 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361031&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124159701 386400421 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713458 N[C@@H](CNS(=O)(=O)c1ccc(-c2cccc3[nH]c(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O)C(N)=O InChI=1S/C17H17N11O5S2/c18-9(15(19)29)6-22-35(32,33)11-5-4-7(8-2-1-3-10-13(8)24-17(20)23-10)12(14(11)34(21,30)31)16-25-27-28-26-16/h1-5,9,22H,6,18H2,(H2,19,29)(H2,20,23)(H2,21,30,31)/b8-7+/t9-/m0/s1 HEBMKFORMCSKAU-FLOXNTQESA-N 361032 (2S)-2-amino-3-(4-(2-amino-1H-benzo[d]imidazol-4-yl)-2-sulfamoyl-3-(2H-tetrazol-5-yl)phenylsulfonamido)propanamide::US10221163, Example 189::US10544130, Example 189 Metallo-beta-lactamase type 2 0.615 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361032 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361032&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124159605 386400422 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713461 N[C@@H](CO)CNS(=O)(=O)c1ccc(-c2cccc3[nH]c(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C17H18N10O5S2/c18-8(7-28)6-21-34(31,32)12-5-4-9(10-2-1-3-11-14(10)23-17(19)22-11)13(15(12)33(20,29)30)16-24-26-27-25-16/h1-5,8,21,28H,6-7,18H2,(H2,19,22)(H2,20,29,30)/b10-9+/t8-/m1/s1 KMTZHEVZIGIVOI-KGSKPCQNSA-N 361033 4-(2-amino-1H-benzo[d]imidazol-4-yl)-N1-((R)-2-amino-3-hydroxypropyl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 190::US10544130, Example 190 Metallo-beta-lactamase type 2 0.624 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361033 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361033&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124159603 386400423 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713464 N[C@H](CO)CNS(=O)(=O)c1ccc(-c2cccc3[nH]c(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C17H18N10O5S2/c18-8(7-28)6-21-34(31,32)12-5-4-9(10-2-1-3-11-14(10)23-17(19)22-11)13(15(12)33(20,29)30)16-24-26-27-25-16/h1-5,8,21,28H,6-7,18H2,(H2,19,22)(H2,20,29,30)/b10-9+/t8-/m0/s1 KMTZHEVZIGIVOI-VPOJCXOPSA-N 361034 4-(2-amino-1H-benzo[d]imidazol-4-yl)-N1—((S)-2-amino-3-hydroxypropyl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 191::US10544130, Example 191 Metallo-beta-lactamase type 2 0.433 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361034 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361034&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124159613 386400424 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713467 NC(=N)c1nc2c(cccc2s1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(N)(=O)=O InChI=1S/C15H13N9O4S3/c16-13(17)15-20-11-7(2-1-3-8(11)29-15)6-4-5-9(30(18,25)26)12(31(19,27)28)10(6)14-21-23-24-22-14/h1-5H,(H3,16,17)(H2,18,25,26)(H2,19,27,28)(H,21,22,23,24) PLYWKYGTXVRZIM-UHFFFAOYSA-N 361035 4-(3,4-disulfamoyl-2-(2H-tetrazol-5-yl)phenyl)benzo[d]thiazole-2-carboximidamide::US10221163, Example 192::US10544130, Example 192 Metallo-beta-lactamase type 2 0.699 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361035 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361035&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124159606 386400425 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713470 NS(=O)(=O)c1c(ccc(-c2cccc3[nH]cnc23)c1-c1nn[nH]n1)S(=O)(=O)N[C@@H]1CCNC1 InChI=1S/C18H17N9O4S2/c19-32(28,29)17-14(33(30,31)25-10-6-7-20-8-10)5-4-11(15(17)18-23-26-27-24-18)12-2-1-3-13-16(12)22-9-21-13/h1-5,9-10,20,25H,6-8H2,(H2,19,28,29)/b12-11+/t10-/m1/s1 QTIHTTAMZWPUFN-PJSNMCHCSA-N 361036 4-(1H-benzo[d]imidazol-4-yl)-N1-((R)-pyrrolidin-3-yl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 193::US10544130, Example 193 Metallo-beta-lactamase type 2 0.211 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361036 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361036&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135310900 386400426 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713473 Nc1ccc(cn1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)N[C@@H]1CCNC1 361037 (R)-4-(6-aminopyridin-3-yl)-N1-(pyrrolidin-3-yl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 194::US10544130, Example 194 Metallo-beta-lactamase type 2 0.242 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361037 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361037&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124158480 386400427 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713476 Nc1ccc(cn1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)N[C@H]1CCNC1 361038 (S)-4-(6-aminopyridin-3-yl)-N1-(pyrrolidin-3-yl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 195::US10544130, Example 195 Metallo-beta-lactamase type 2 0.523 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361038 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361038&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124159643 386400428 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713479 NCCNS(=O)(=O)c1ccc(-c2ccc(N)nc2)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C14H17N9O4S2/c15-5-6-19-29(26,27)10-3-2-9(8-1-4-11(16)18-7-8)12(13(10)28(17,24)25)14-20-22-23-21-14/h1-4,7,19H,5-6,15H2,(H2,16,18)(H2,17,24,25)(H,20,21,22,23) KXELUNLBQPTQIB-UHFFFAOYSA-N 361039 N1-(2-aminoethyl)-4-(6-aminopyridin-3-yl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 196::US10544130, Example 196 Metallo-beta-lactamase type 2 0.479 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361039 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361039&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124158237 386400429 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713482 NS(=O)(=O)c1c(ccc(-c2cccc3[nH]cnc23)c1-c1nn[nH]n1)S(=O)(=O)N[C@H]1CCNC1 InChI=1S/C18H17N9O4S2/c19-32(28,29)17-14(33(30,31)25-10-6-7-20-8-10)5-4-11(15(17)18-23-26-27-24-18)12-2-1-3-13-16(12)22-9-21-13/h1-5,9-10,20,25H,6-8H2,(H2,19,28,29)/b12-11+/t10-/m0/s1 QTIHTTAMZWPUFN-IUZMTQGWSA-N 361040 4-(1H-benzo[d]imidazol-4-yl)-N1—(S)-pyrrolidin-3-yl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 197::US10544130, Example 197 Metallo-beta-lactamase type 2 0.395 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361040 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361040&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124159675 386400430 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 714223 NCCNS(=O)(=O)c1ccc(-c2cccc3[nH]c(nc23)[C@@H]2C[C@@H](O)CN2)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C20H22N10O5S2/c21-6-7-24-37(34,35)15-5-4-11(16(18(15)36(22,32)33)20-27-29-30-28-20)12-2-1-3-13-17(12)26-19(25-13)14-8-10(31)9-23-14/h1-5,10,14,23-24,31H,6-9,21H2,(H2,22,32,33)/b12-11+/t10-,14+/m1/s1 FURQKPFVDFTLFW-SQXJLYEZSA-N 361287 N1-(2-aminoethyl)-4-(2- ((2S,4R)-4- hydroxypyrrolidin-2-yl)-1H- benzo[d]imidazol-4-yl)-3- (2H-tetrazol-5-yl)benzene- 1,2-disulfonamide::US10221163, Example 444::US10544130, Example 444 Metallo-beta-lactamase type 2 1.59 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361287 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361287&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311012 386400675 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 714226 NCCNS(=O)(=O)c1ccc(-c2cccc3[nH]c(nc23)C(F)(F)CN)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C18H20F2N10O4S2/c19-18(20,8-22)17-25-11-3-1-2-10(14(11)26-17)9-4-5-12(36(33,34)24-7-6-21)15(35(23,31)32)13(9)16-27-29-30-28-16/h1-5,24H,6-8,21-22H2,(H,25,26)(H2,23,31,32)(H,27,28,29,30) BSSOREZAYOZEAB-UHFFFAOYSA-N 361288 4-(2-(2-amino-1,1- difluoroethyl)-1H- benzo[d]imidazol-4-yl)-N1- (2-aminoethyl)-3-(2H- tetrazol-5-yl)benzene-1,2- disulfonamide::US10221163, Example 445::US10544130, Example 445 Metallo-beta-lactamase type 2 0.370 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361288 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361288&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135310710 386400676 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 714229 NCC(F)(F)c1nc2c(cccc2[nH]1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)N[C@H]1CCNC1 InChI=1S/C20H20F2N10O4S2/c21-20(22,9-23)19-26-13-3-1-2-12(16(13)27-19)11-4-5-14(38(35,36)30-10-6-7-25-8-10)17(37(24,33)34)15(11)18-28-31-32-29-18/h1-5,10,25,30H,6-9,23H2,(H2,24,33,34)/b12-11+/t10-/m0/s1 LRUAIGJOZPWOOH-IUZMTQGWSA-N 361289 (S)-4-(2-(2-amino-1,1- difluoroethyl)-1H- benzo[d]imidazol-4-yl)-N1- (pyrrolidin-3-yl)-3-(2H- tetrazol-5-yl)benzene-1,2- disulfonamide::US10221163, Example 446::US10544130, Example 446 Metallo-beta-lactamase type 2 0.446 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361289 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361289&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135310917 386400677 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 714232 NCCNC(=O)c1cc(Cl)cc(c1N)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)NCCN InChI=1S/C18H23ClN10O5S2/c19-9-7-11(15(22)12(8-9)18(30)24-5-3-20)10-1-2-13(36(33,34)25-6-4-21)16(35(23,31)32)14(10)17-26-28-29-27-17/h1-2,7-8,25H,3-6,20-22H2,(H,24,30)(H2,23,31,32)(H,26,27,28,29) BOWSJWYIIKQERX-UHFFFAOYSA-N 361290 2-Amino-N-(2-aminoethyl)-4′-(N-(2-aminoethyl)sulfamoyl)-5-chloro-3′-sulfamoyl-2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-3-carboxamide::US10221163, Example 447::US10544130, Example 447 Metallo-beta-lactamase type 2 1.60 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361290 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361290&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124158313 386400678 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 714235 N[C@@H]1C[C@H]1NS(=O)(=O)c1ccc(-c2cccc3[nH]c(N)nc23)c(-c2nnn[nH]2)c1S(N)(=O)=O InChI=1S/C17H16N10O4S2/c18-9-6-11(9)25-33(30,31)12-5-4-7(8-2-1-3-10-14(8)22-17(19)21-10)13(15(12)32(20,28)29)16-23-26-27-24-16/h1-5,9,11,25H,6,18H2,(H2,19,21)(H2,20,28,29)/b8-7+/t9-,11-/m1/s1 KAEOIIUECHQSQD-FQZVFUSHSA-N 361291 4-(2-amino-1H-benzo[d]imidazol-4-yl)-N1-((1R,2R)-2-aminocyclopropyl)-3-(1H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 448::US10544130, Example 448 Metallo-beta-lactamase type 2 0.988 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361291 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361291&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311433 386400679 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 714238 CN(CCN)S(=O)(=O)c1ccc(-c2cccc3[nH]c(N)nc23)c(C2=NNNN2)c1S(N)(=O)=O InChI=1S/C17H22N10O4S2/c1-27(8-7-18)33(30,31)12-6-5-9(10-3-2-4-11-14(10)22-17(19)21-11)13(15(12)32(20,28)29)16-23-25-26-24-16/h2-6,25-26H,7-8,18H2,1H3,(H,23,24)(H3,19,21,22)(H2,20,28,29) JZKYMSARIZSXPD-UHFFFAOYSA-N 361292 4-(2-amino-1H-benzo[d]imidazol-4-yl)-N1-(2-aminoethyl)-N1-methyl-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 449 Metallo-beta-lactamase type 2 11.8 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361292 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361292&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 137537619 386400680 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 714241 NCCNC(=O)c1cc(Cl)cc(c1N)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)NC1CCNC1 361293 (R)-2-Amino-N-(2-aminoethyl)-5-chloro-4′-(N-(pyrrolidin-3-yl)sulfamoyl)-3′-sulfamoyl-2′-(2H-tetrazol-5-yl-[1,1′-biphenyl]-3-carboxamide::US10221163, Example 450 Metallo-beta-lactamase type 2 3.42 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361293 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361293&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 137537597 386400681 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 714244 NCCNC(=O)c1cc(ccc1N)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)NCCN InChI=1S/C18H24N10O5S2/c19-5-7-23-18(29)12-9-10(1-3-13(12)21)11-2-4-14(35(32,33)24-8-6-20)16(34(22,30)31)15(11)17-25-27-28-26-17/h1-4,9,24H,5-8,19-21H2,(H,23,29)(H2,22,30,31)(H,25,26,27,28) MHMCEJWETAYNFG-UHFFFAOYSA-N 361294 4-Amino-N-(2-aminoethyl)-4′-(N-(2-aminoethyl)sulfamoyl)-3′-sulfamoyl-2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-3-carboxamide::US10221163, Example 451::US10544130, Example 451 Metallo-beta-lactamase type 2 4.02 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361294 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361294&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135310881 386400682 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 714247 NCCNS(=O)(=O)c1ccc(-c2ccccc2NC(=O)CN)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C17H21N9O5S2/c18-7-8-21-33(30,31)13-6-5-11(10-3-1-2-4-12(10)22-14(27)9-19)15(16(13)32(20,28)29)17-23-25-26-24-17/h1-6,21H,7-9,18-19H2,(H,22,27)(H2,20,28,29)(H,23,24,25,26) AUDKQARKDIVADP-UHFFFAOYSA-N 361295 2-Amino-N-(4′-(N-(2-aminoethyl)sulfamoyl)-3′-sulfamoyl-2′-(2H-tetrazol-5-yl-[1,1′-biphenyl]-2-yl)acetamide::US10221163, Example 452::US10544130, Example 452 Metallo-beta-lactamase type 2 6.21 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361295 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361295&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 137537562 386400683 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 714250 NCCNS(=O)(=O)c1ccc(-c2cccc(NC(=O)[C@@H](N)CN)c2)c(-c2nn[nH]n2)c1S(N)(=O)=O 361296 (S)-2,3-Diamino-N-(4′-(N-(2-aminoethyl)sulfamoyl)-3′-sulfamoyl-2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-3-yl)propanamide::US10221163, Example 453::US10544130, Example 453 Metallo-beta-lactamase type 2 3.52 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361296 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361296&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124158225 386400684 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 714253 NCCNS(=O)(=O)c1ccc(-c2cccc(NC(=O)[C@H](N)CO)c2)c(-c2nn[nH]n2)c1S(N)(=O)=O 361297 (R)-2-amino-N-(4'-(N-(2- aminoethyl)sulfamoyl)-3'- sulfamoyl-2'-(2H-tetrazol-5- yl)-[1,1'-biphenyl]-3-yl)-3- hydroxypropanamide::US10221163, Example 454::US10544130, Example 454 Metallo-beta-lactamase type 2 3.46 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361297 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361297&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311893 386400685 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 714256 NCCNS(=O)(=O)c1ccc(-c2cccc3NCCCc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C18H22N8O4S2/c19-8-10-22-32(29,30)15-7-6-13(11-3-1-5-14-12(11)4-2-9-21-14)16(17(15)31(20,27)28)18-23-25-26-24-18/h1,3,5-7,21-22H,2,4,8-10,19H2,(H2,20,27,28)(H,23,24,25,26) GQMKFJFLZZHKEE-UHFFFAOYSA-N 361298 N1-(2-Aminoethyl)-4-(1,2,3,4-tetrahydroquinolin-5-yl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 455::US10544130, Example 455 Metallo-beta-lactamase type 2 0.530 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361298 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361298&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311072 386400686 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 714259 NCCNc1cc(ccn1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)NCCN InChI=1S/C16H22N10O4S2/c17-4-7-21-13-9-10(3-6-20-13)11-1-2-12(32(29,30)22-8-5-18)15(31(19,27)28)14(11)16-23-25-26-24-16/h1-3,6,9,22H,4-5,7-8,17-18H2,(H,20,21)(H2,19,27,28)(H,23,24,25,26) OZTGBIOQFYIWIA-UHFFFAOYSA-N 361299 N1-(2-Aminoethyl)-4-(2-((2-aminoethyl)amino)pyridin-4-yl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 456::US10544130, Example 456 Metallo-beta-lactamase type 2 3.77 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361299 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361299&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135310935 386400687 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 714262 NCCNc1cc(ccn1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)NCCO InChI=1S/C16H21N9O5S2/c17-4-6-20-13-9-10(3-5-19-13)11-1-2-12(32(29,30)21-7-8-26)15(31(18,27)28)14(11)16-22-24-25-23-16/h1-3,5,9,21,26H,4,6-8,17H2,(H,19,20)(H2,18,27,28)(H,22,23,24,25) ARBCOGFEJXLOLI-UHFFFAOYSA-N 361300 4-(2-((2- aminoethyl)amino)pyridin-4- yl)-N1-(2-hydroxyethyl)-3- (2H-tetrazol-5-yl)benzene- 1,2-disulfonamide::US10221163, Example 457::US10544130, Example 457 Metallo-beta-lactamase type 2 5.29 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361300 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361300&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311300 386400688 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 714265 NCCNc1cc(ccn1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)N[C@@H]1CCNC1 361301 (R)-4-(2-((2- aminoethyl)amino)pyridin-4- yl)-N1-(pyrrolidin-3-yl)-3- (2H-tetrazol-5-yl)benzene- 1,2-disulfonamide::US10221163, Example 458::US10544130, Example 458 Metallo-beta-lactamase type 2 3.77 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361301 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361301&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311249 386400689 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 714268 NCCNc1ncccc1-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)N[C@@H]1CCNC1 361302 (R)-4-(2-((2- Aminoethyl)amino)pyridin- 3-yl)-N1-(pyrrolidin-3-yl)-3- (2H-tetrazol-5-yl)benzene- 1,2-disulfonamide::US10221163, Example 459::US10544130, Example 459 Metallo-beta-lactamase type 2 12.5 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361302 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361302&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311524 386400690 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 714271 C[C@H](CN)NS(=O)(=O)c1ccc(-c2cccnc2NCCN)c(-c2nn[nH]n2)c1S(N)(=O)=O 361303 (R)-4-(2-((2- aminoethyl)amino)pyridin-3 yl)-N1-(1-aminopropan-2- yl)-3-(2H-tetrazol-5- yl)benzene-1,2- disulfonamide::US10221163, Example 460::US10544130, Example 460 Metallo-beta-lactamase type 2 4.63 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361303 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361303&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311186 386400691 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 714274 NCCNS(=O)(=O)c1ccc(-c2ccnc(CN)c2)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C15H19N9O4S2/c16-4-6-20-30(27,28)12-2-1-11(9-3-5-19-10(7-9)8-17)13(14(12)29(18,25)26)15-21-23-24-22-15/h1-3,5,7,20H,4,6,8,16-17H2,(H2,18,25,26)(H,21,22,23,24) RFCNFEVBCWVNCO-UHFFFAOYSA-N 361304 N1-(2-Aminoethyl)-4-(2-(aminomethyl)pyridin-4-yl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 461::US10544130, Example 461 Metallo-beta-lactamase type 2 50.4 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361304 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361304&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269292 386400692 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 714277 NCc1nc(c[nH]1)-c1cccc(c1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)N[C@H]1CNC[C@H]1N 361305 (R)-3′-(2-(aminomethyl)-1H-imidazol-4-yl)-N4-(2-aminopropyl)-2-(2H -tetrazol-5-yl-[1,1′-biphenyl]-3,4-disulfonamide::US10221163, Example 462::US10544130, Example 462 Metallo-beta-lactamase type 2 1.29 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361305 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361305&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135310696 386400693 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 714280 NC[C@@H](O)CNS(=O)(=O)c1ccc(-c2ccc3sc(CN)nc3c2)c(-c2nn[nH]n2)c1S(N)(=O)=O 361306 (R)—N1-(3-amino-2-hydroxypropyl)-4-(2-(aminomethyl)benzo[d]thiazol-5-yl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 463::US10544130, Example 463 Metallo-beta-lactamase type 2 0.325 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361306 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361306&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311067 386400694 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 50757233 Nc1cccc(c1)-c1cc(nc(c1)C(O)=O)C(O)=O InChI=1S/C13H10N2O4/c14-9-3-1-2-7(4-9)8-5-10(12(16)17)15-11(6-8)13(18)19/h1-6H,14H2,(H,16,17)(H,18,19) FXWFQAQXUDVIOS-UHFFFAOYSA-N 50240870 CHEMBL4068259 Metallo-beta-lactamase type 2 240 ChEMBL 10.1021/acs.jmedchem.7b00407 10.7270/Q2P27185 28809565 Chen, AY; Thomas, PW; Stewart, AC; Bergstrom, A; Cheng, Z; Miller, C; Bethel, CR; Marshall, SH; Credille, CV; Riley, CL; Page, RC; Bonomo, RA; Crowder, MW; Tierney, DL; Fast, W; Cohen, SM University of California San Diego http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50240870 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50240870&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 137631612 386401559 CHEMBL4068259 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 50757234 OC(=O)c1cccc(n1)C(O)=O InChI=1S/C7H5NO4/c9-6(10)4-2-1-3-5(8-4)7(11)12/h1-3H,(H,9,10)(H,11,12) WJJMNDUMQPNECX-UHFFFAOYSA-N 26116 CHEMBL284104::Dipicolinate::pyridine carboxylate, 6d::pyridine-2,6-dicarboxylic acid Metallo-beta-lactamase type 2 3030 ChEMBL 10.1021/acs.jmedchem.7b00407 10.7270/Q2P27185 28809565 Chen, AY; Thomas, PW; Stewart, AC; Bergstrom, A; Cheng, Z; Miller, C; Bethel, CR; Marshall, SH; Credille, CV; Riley, CL; Page, RC; Bonomo, RA; Crowder, MW; Tierney, DL; Fast, W; Cohen, SM University of California San Diego http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26116 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26116&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search PDC 5US6,2PC2,1ARZ,5TEM,4IRW,1P9L,5CQ6,4IH3,1C3V,3OJO,2PES,2PE7,5TJY,5TJZ,3LGR,5Z2F,5Z2E 10367 56464553 46837 CHEMBL284104 DB04267 ZINC00105246 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713485 NCCCNS(=O)(=O)c1ccc(-c2cccc3[nH]cnc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C17H19N9O4S2/c18-7-2-8-22-32(29,30)13-6-5-10(11-3-1-4-12-15(11)21-9-20-12)14(16(13)31(19,27)28)17-23-25-26-24-17/h1,3-6,9,22H,2,7-8,18H2,(H,20,21)(H2,19,27,28)(H,23,24,25,26) PULJZVSXVWZSIQ-UHFFFAOYSA-N 361041 N1-(3-aminopropyl)-4-(1H-benzo[d]imidazol-4-yl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 198::US10544130, Example 198 Metallo-beta-lactamase type 2 0.293 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361041 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361041&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124159585 386400431 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713488 NCCNS(=O)(=O)c1ccc(-c2cccc3[nH]cnc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C16H17N9O4S2/c17-6-7-21-31(28,29)12-5-4-9(10-2-1-3-11-14(10)20-8-19-11)13(15(12)30(18,26)27)16-22-24-25-23-16/h1-5,8,21H,6-7,17H2,(H,19,20)(H2,18,26,27)(H,22,23,24,25) ABGWLUMGGAKQLX-UHFFFAOYSA-N 361042 N1-(2-aminoethyl)-4-(1H-benzo[d]imidazol-4-yl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 199::US10544130, Example 199 Metallo-beta-lactamase type 2 0.102 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361042 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361042&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124159679 386400432 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713491 N[C@H]1C[C@@H](C1)NS(=O)(=O)c1ccc(-c2cccc3[nH]cnc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C18H17N9O4S2/c19-9-6-10(7-9)25-33(30,31)14-5-4-11(12-2-1-3-13-16(12)22-8-21-13)15(17(14)32(20,28)29)18-23-26-27-24-18/h1-5,8-10,25H,6-7,19H2,(H2,20,28,29)/b12-11+/t9-,10- LRCUVYRGBKTSDV-SXPMVVMESA-N 361043 N1-((1r,3r)-3-aminocyclobutyl)-4-(1H-benzo[d]imidazol-4-yl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 200::US10544130, Example 200 Metallo-beta-lactamase type 2 0.276 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361043 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361043&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124159650 386400433 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713494 NCC(CO)NS(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nnn[nH]2)c1S(N)(=O)=O 361044 (S)—N1-(1-amino-3-hydroxypropan-2-yl)-4-(2-aminobenzo[d]thiazol-4-yl)-3-(1H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 201::US10544130, Example 201 Metallo-beta-lactamase type 2 0.109 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361044 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361044&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135310725 386400434 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713497 NC[C@H](CO)NS(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nnn[nH]2)c1S(N)(=O)=O 361045 (R)—N1-(1-amino-3-hydroxypropan-2-yl)-4-(2-aminobenzo[d]thiazol-4-yl)-3-(1H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 202::US10544130, Example 202 Metallo-beta-lactamase type 2 0.713 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361045 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361045&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135310972 386400435 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713500 NCCOCCNS(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nnn[nH]2)c1S(N)(=O)=O InChI=1S/C18H21N9O5S3/c19-6-8-32-9-7-22-35(30,31)13-5-4-10(11-2-1-3-12-15(11)23-18(20)33-12)14(16(13)34(21,28)29)17-24-26-27-25-17/h1-5,22H,6-9,19H2,(H2,20,23)(H2,21,28,29)(H,24,25,26,27) KCKDRBGQJWHVTE-UHFFFAOYSA-N 361046 4-(2-aminobenzo[d]thiazol-4-yl)-N1-(2-(2-aminoethoxy)ethyl)-3-(1H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 203::US10544130, Example 203 Metallo-beta-lactamase type 2 0.199 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361046 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361046&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124158475 386400436 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713503 NCCNC(=O)c1cccc(c1N)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)NCCN InChI=1S/C18H24N10O5S2/c19-6-8-23-18(29)12-3-1-2-11(15(12)21)10-4-5-13(35(32,33)24-9-7-20)16(34(22,30)31)14(10)17-25-27-28-26-17/h1-5,24H,6-9,19-21H2,(H,23,29)(H2,22,30,31)(H,25,26,27,28) KJCSBMYFBQKAEH-UHFFFAOYSA-N 361047 2-amino-N-(2-aminoethyl)-4′-(N-(2-aminoethyl)sulfamoyl)-5′-sulfamoyl-6′-(2H-tetrazol-5-yl)biphenyl-3-carboxamide::US10221163, Example 204::US10544130, Example 204 Metallo-beta-lactamase type 2 2.56 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361047 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361047&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124158412 386400437 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713506 N[C@@H]1CN(CC[C@H]1F)S(=O)(=O)c1ccc(-c2cccc3[nH]c(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C19H21FN10O4S2/c20-11-6-7-30(8-12(11)21)36(33,34)14-5-4-9(10-2-1-3-13-16(10)25-19(22)24-13)15(17(14)35(23,31)32)18-26-28-29-27-18/h1-5,11-12H,6-8,21H2,(H3,22,24,25)(H2,23,31,32)(H,26,27,28,29)/t11-,12-/m1/s1 JZQVOGXMDSVEHZ-VXGBXAGGSA-N 361048 3-(2-amino-1H-benzo[d]imidazol-4-yl)-6-(((3R,4R)-3-amino-4-fluoropiperidin-1-yl)sulfonyl)-2-(2H-tetrazol-5-yl)benzenesulfonamide::US10221163, Example 205::US10544130, Example 205 Metallo-beta-lactamase type 2 5.89 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361048 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361048&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124158291 386400438 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713509 Nc1nc2c(cccc2[nH]1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)NCC1COCCN1 InChI=1S/C19H20N10O5S2/c20-19-24-13-3-1-2-12(16(13)25-19)11-4-5-14(36(32,33)23-8-10-9-34-7-6-22-10)17(35(21,30)31)15(11)18-26-28-29-27-18/h1-5,10,22-23H,6-9H2,(H2,20,24)(H2,21,30,31)/b12-11- CYOWKSPYSUDGIS-QXMHVHEDSA-N 361049 4-(2-amino-1H-benzo[d]imidazol-4-yl)-N1-(morpholin-3-ylmethyl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 206::US10544130, Example 206 Metallo-beta-lactamase type 2 0.498 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361049 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361049&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135310743 386400439 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713512 Nc1nc2c(cccc2[nH]1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)NCC1CCN1 InChI=1S/C18H18N10O4S2/c19-18-23-12-3-1-2-11(15(12)24-18)10-4-5-13(34(31,32)22-8-9-6-7-21-9)16(33(20,29)30)14(10)17-25-27-28-26-17/h1-5,9,21-22H,6-8H2,(H2,19,23)(H2,20,29,30)/b11-10- GFYANUUMIUZHJQ-KHPPLWFESA-N 361050 4-(2-amino-1H-benzo[d]imidazol-4-yl)-N1-(azetidin-2-ylmethyl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 207::US10544130, Example 207 Metallo-beta-lactamase type 2 0.999 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361050 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361050&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311132 386400440 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713515 C[C@H](N)CC(=O)NS(=O)(=O)c1ccc(-c2cccc3[nH]c(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C18H20N10O5S2/c1-8(19)7-13(29)26-35(32,33)12-6-5-9(10-3-2-4-11-15(10)23-18(20)22-11)14(16(12)34(21,30)31)17-24-27-28-25-17/h2-6,8H,7,19H2,1H3,(H,26,29)(H3,20,22,23)(H2,21,30,31)(H,24,25,27,28)/t8-/m0/s1 PJDYNGJJKINRRX-QMMMGPOBSA-N 361051 (S)-3-amino-N-((4-(2-amino-1H-benzo[d]imidazol-4-yl)-2-sulfamoyl-3-(2H-tetrazol-5-yl)phenyl)sulfonyl)butanamide::US10221163, Example 208::US10544130, Example 208 Metallo-beta-lactamase type 2 3.12 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361051 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361051&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124158504 386400441 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713518 Nc1ncccc1-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)N[C@@H]1CCNC1 InChI=1S/C16H19N9O4S2/c17-15-11(2-1-6-20-15)10-3-4-12(31(28,29)23-9-5-7-19-8-9)14(30(18,26)27)13(10)16-21-24-25-22-16/h1-4,6,9,19,23H,5,7-8H2,(H2,17,20)(H2,18,26,27)(H,21,22,24,25)/t9-/m1/s1 UQTMNFPUWSWOOK-SECBINFHSA-N 361052 (R)-4-(2-aminopyridin-3-yl)-N1-(pyrrolidin-3-yl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 209::US10544130, Example 209 Metallo-beta-lactamase type 2 3.10 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361052 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361052&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124158459 386400442 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713521 NCC(CN)NS(=O)(=O)c1ccc(-c2cccnc2N)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C15H20N10O4S2/c16-6-8(7-17)23-31(28,29)11-4-3-9(10-2-1-5-20-14(10)18)12(13(11)30(19,26)27)15-21-24-25-22-15/h1-5,8,23H,6-7,16-17H2,(H2,18,20)(H2,19,26,27)(H,21,22,24,25) UVVRKQCYJNZZBP-UHFFFAOYSA-N 361053 4-(2-aminopyridin- 3-yl)-N1-(1,3- diaminopropan-2- yl)-3-(2H-tetrazol-5- yl)benzene-1,2- disulfonamide::US10221163, Example 210::US10544130, Example 210 Metallo-beta-lactamase type 2 1.50 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361053 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361053&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311331 386400443 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713524 CC(C)(CN)NS(=O)(=O)c1ccc(-c2cccnc2N)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C16H21N9O4S2/c1-16(2,8-17)23-31(28,29)11-6-5-9(10-4-3-7-20-14(10)18)12(13(11)30(19,26)27)15-21-24-25-22-15/h3-7,23H,8,17H2,1-2H3,(H2,18,20)(H2,19,26,27)(H,21,22,24,25) YREYWLTWIWCHHP-UHFFFAOYSA-N 361054 N1-(1-amino-2- methylpropan-2-yl)- 4-(2-aminopyridin- 3-yl)-3-(2H- tetrazol-5- yl)benzene-1,2- disulfonamide::US10221163, Example 211::US10544130, Example 211 Metallo-beta-lactamase type 2 2.25 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361054 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361054&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311850 386400444 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713527 C[C@H](CN)NS(=O)(=O)c1ccc(-c2cccnc2N)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C15H19N9O4S2/c1-8(7-16)22-30(27,28)11-5-4-9(10-3-2-6-19-14(10)17)12(13(11)29(18,25)26)15-20-23-24-21-15/h2-6,8,22H,7,16H2,1H3,(H2,17,19)(H2,18,25,26)(H,20,21,23,24)/t8-/m1/s1 HVZNGQAYECGPHO-MRVPVSSYSA-N 361055 (R)-N1-(1-amino- propan-2-yl)-4- (2-aminopyridin-3- yl)-3-(2H- tetrazol-5- yl)benzene-1,2- disulfonamide::US10221163, Example 212::US10544130, Example 212 Metallo-beta-lactamase type 2 1.07 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361055 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361055&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135310828 386400445 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713530 NC[C@H](N)CNS(=O)(=O)c1ccc(-c2cccnc2N)c(-c2nn[nH]n2)c1S(N)(=O)=O 361056 (S)-4-(2- aminopyridin- 3-yl)-N1-(2,3- diaminopropyl)-3- (2H-tetrazol-5- yl)benzene-1,2- disulfonamide::US10221163, Example 213::US10544130, Example 213 Metallo-beta-lactamase type 2 1.54 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361056 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361056&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311376 386400446 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713533 N[C@@H](CO)CNS(=O)(=O)c1ccc(-c2cccnc2N)c(-c2nn[nH]n2)c1S(N)(=O)=O 361057 (R)-N1-(2-amino- 3-hydroxypropyl)- 4-(2-amino- pyridin-3-yl)-3- (2H-tetrazol-5- yl)benzene-1,2- disulfonamide::US10221163, Example 214::US10544130, Example 214 Metallo-beta-lactamase type 2 8.49 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361057 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361057&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311455 386400447 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713536 NC[C@H](CO)NS(=O)(=O)c1ccc(-c2cccnc2N)c(-c2nn[nH]n2)c1S(N)(=O)=O 361058 (R)-N1-(1-amino- 3-hydroxypropan- 2-yl)-4-(2- aminopyridin-3- yl)-3-(2H-tetrazol- 5-yl)benzene-1,2- disulfonamide::US10221163, Example 215::US10544130, Example 215 Metallo-beta-lactamase type 2 2.12 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361058 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361058&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311166 386400448 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713539 NC1C[C@@H]1NS(=O)(=O)c1ccc(-c2cccnc2N)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C15H17N9O4S2/c16-9-6-10(9)22-30(27,28)11-4-3-7(8-2-1-5-19-14(8)17)12(13(11)29(18,25)26)15-20-23-24-21-15/h1-5,9-10,22H,6,16H2,(H2,17,19)(H2,18,25,26)(H,20,21,23,24)/t9?,10-/m0/s1 NRGZZANDJWYHMJ-AXDSSHIGSA-N 361059 N1-((1S)-2-amino- cyclopropyl)-4-(2- aminopyridin-3-yl)- 3-(2H-tetrazol-5- yl)benzene-1,2- disulfonamide::US10221163, Example 216 Metallo-beta-lactamase type 2 1.83 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361059 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361059&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311297 386400449 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713542 Nc1ccc(cn1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)NCCc1c[nH]cn1 InChI=1S/C17H18N10O4S2/c18-14-4-1-10(7-21-14)12-2-3-13(33(30,31)23-6-5-11-8-20-9-22-11)16(32(19,28)29)15(12)17-24-26-27-25-17/h1-4,7-9,23H,5-6H2,(H2,18,21)(H,20,22)(H2,19,28,29)(H,24,25,26,27) JRUSWFUCBJJDSX-UHFFFAOYSA-N 361060 N1-(2-(1H-imidazol-4-yl)ethyl)-4-(6-aminopyridin-3-yl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 217::US10544130, Example 217 Metallo-beta-lactamase type 2 0.505 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361060 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361060&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269221 386400450 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 714283 NC[C@@H](O)CNS(=O)(=O)c1ccc(-c2ccc3[nH]c(CN)nc3c2)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C18H20N10O5S2/c19-6-10(29)8-22-35(32,33)14-4-2-11(9-1-3-12-13(5-9)24-15(7-20)23-12)16(17(14)34(21,30)31)18-25-27-28-26-18/h1-5,10,22,29H,6-8,19-20H2,(H2,21,30,31)/b11-9+/t10-/m1/s1 WZIIXEJTRGFYTP-OYVNLZQHSA-N 361307 (R)—N1-(3-amino-2-hydroxypropyl)-4-(2-(aminomethyl)-1H-benzo[d]imidazole-5-yl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 464::US10544130, Example 464 Metallo-beta-lactamase type 2 1.84 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361307 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361307&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311210 386400695 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 714286 NC[C@H](O)CNS(=O)(=O)c1ccc(-c2ccc3[nH]c(CN)nc3c2)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C18H20N10O5S2/c19-6-10(29)8-22-35(32,33)14-4-2-11(9-1-3-12-13(5-9)24-15(7-20)23-12)16(17(14)34(21,30)31)18-25-27-28-26-18/h1-5,10,22,29H,6-8,19-20H2,(H2,21,30,31)/b11-9+/t10-/m0/s1 WZIIXEJTRGFYTP-SPQRFVMMSA-N 361308 S)-N1-(3-amino-2- hydroxypropyl)-4-(2- (aminomethyl)-1H-benzo[d] imidazol-5-yl)-3-(2H- tetrazol-5-yl)benzene-1,2- disulfonamide::US10221163, Example 465::US10544130, Example 465 Metallo-beta-lactamase type 2 1.15 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361308 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361308&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 137537681 386400696 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 714289 NCCNS(=O)(=O)c1ccc(-c2ccc3[nH]c(CN)nc3c2)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C17H20N10O4S2/c18-5-6-21-33(30,31)13-4-2-10(9-1-3-11-12(7-9)23-14(8-19)22-11)15(16(13)32(20,28)29)17-24-26-27-25-17/h1-4,7,21H,5-6,8,18-19H2,(H,22,23)(H2,20,28,29)(H,24,25,26,27) FLIUGCCDOLARIN-UHFFFAOYSA-N 361309 N1-(2-aminoethyl)-4-(2-(aminomethyl)-1H-benzo[d]imidazol-5-yl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 466::US10544130, Example 466 Metallo-beta-lactamase type 2 0.967 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361309 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361309&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311039 386400697 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 714292 CNc1nc2c(cccc2[nH]1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)NCCN InChI=1S/C17H20N10O4S2/c1-20-17-22-11-4-2-3-10(14(11)23-17)9-5-6-12(33(30,31)21-8-7-18)15(32(19,28)29)13(9)16-24-26-27-25-16/h2-6,21H,7-8,18H2,1H3,(H2,19,28,29)(H2,20,22,23)(H,24,25,26,27) IAQFFDQRSKBBQD-UHFFFAOYSA-N 361310 N1-(2-aminoethyl)-4-(2- (methylamino)-1H- benzo[d]imidazol-4-yl)-3- (2H-tetrazol-5-yl)benzene-1,2- disulfonamide::US10221163, Example 467::US10544130, Example 467 Metallo-beta-lactamase type 2 0.437 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361310 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361310&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311436 386400698 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 714295 Cc1cc(cnc1N)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)NC[C@@H](O)CN 361311 (S)-N1-(3-amino-2- hydroxypropyl)-4-(6-amino-5- methylpyridin-3-yl)-3-(2H- tetrazol-5-yl)benzene-1,2- disulfonamide::US10221163, Example 468::US10544130, Example 468 Metallo-beta-lactamase type 2 0.569 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361311 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361311&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311025 386400699 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 714298 NC[C@H](O)CNS(=O)(=O)c1ccc(-c2cnc(N)c(F)c2)c(-c2nn[nH]n2)c1S(N)(=O)=O 361312 (S)-N1-(3-amino-2- hydroxypropyl)-4-(6-amino-5- fluoropyridin-3-yl)-3-(2H- tetrazol-5-yl)benzene-1,2- disulfonamide::US10221163, Example 469::US10544130, Example 469 Metallo-beta-lactamase type 2 0.554 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361312 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361312&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311277 386400700 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 714301 NS(=O)(=O)c1c(ccc(-c2cccc(Nc3nc(CO)cs3)c2)c1-c1nn[nH]n1)S(=O)(=O)N[C@@H]1CCNC1 361313 (R)-3'-((4- (hydroxymethyl)thiazol-2- yl)amino)-N4-(pyrrolidin-3-yl)- 2-(2H-tetrazol-5-yl)-[1,1'- biphenyl]-3,4-disulfonamide::US10221163, Example 470::US10544130, Example 470 Metallo-beta-lactamase type 2 0.134 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361313 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361313&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311508 386400701 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 714304 NC(=O)c1csc(Nc2cccc(c2)-c2ccc(c(c2-c2nn[nH]n2)S(N)(=O)=O)S(=O)(=O)N[C@@H]2CCNC2)n1 361314 (R)-2-((4′-(N-(pyrrolidin-3-yl)sulfamoyl)-3′-sulfamoyl-2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-3-yl)amino)thiazole-4-carboxamide::BDBM427635::US10221163, Example 471 Metallo-beta-lactamase type 2 0.111 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361314 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361314&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124158369 386400702 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 714307 NS(=O)(=O)c1c(ccc(-c2cccc(Nc3ncc[nH]3)c2)c1-c1nn[nH]n1)S(=O)(=O)N[C@H]1CCNC1 361315 (R)-N1-(3- (aminomethyl)pyrrolidin-3-yl)- 4-(6-aminopyridin-3-yl)-3 - (2H-tetrazol-5-yl)benzene-1,2- disulfonamide dihydrochloride::US10221163, Example 472::US10544130, Example 472 Metallo-beta-lactamase type 2 0.847 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361315 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361315&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 137537743 386400703 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 714310 NC[C@H](O)CNS(=O)(=O)c1ccc(-c2ccc3sc(CN)nc3c2)c(-c2nn[nH]n2)c1S(N)(=O)=O 361316 (S)-N1-(3-amino-2- hydroxypropyl)-4-(2- (aminomethyl)benzo[d]thiazol- 5-yl)-3-(2H-tetrazol-5- yl)benzene-1,2-disulfonamide::US10221163, Example 473::US10544130, Example 473 Metallo-beta-lactamase type 2 0.329 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361316 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361316&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311423 386400704 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 714313 NC[C@@H](CO)NS(=O)(=O)c1ccc(-c2ccc3[nH]c(CN)nc3c2)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C18H20N10O5S2/c19-6-10(8-29)26-35(32,33)14-4-2-11(9-1-3-12-13(5-9)23-15(7-20)22-12)16(17(14)34(21,30)31)18-24-27-28-25-18/h1-5,10,26,29H,6-8,19-20H2,(H2,21,30,31)/b11-9+/t10-/m0/s1 FBSOKGRQTNLARE-SPQRFVMMSA-N 361317 (S)-N1-(1-amino-3- hydroxypropan-2-yl)-4-(2- (aminomethyl)-1H-benzo[d] imidazol-5-yl)-3-(2H- tetrazol-5-yl)benzene-1,2- disulfonamide::US10221163, Example 474::US10544130, Example 474 Metallo-beta-lactamase type 2 0.522 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361317 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361317&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135310983 386400705 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 714316 NC[C@@H](CO)NS(=O)(=O)c1ccc(-c2ccc3sc(CN)nc3c2)c(-c2nn[nH]n2)c1S(N)(=O)=O 361318 (S)-N1-(1-amino-3- hydroxypropan-2-yl)-4-(2- (aminomethyl)benzo[d]thiazol- 5-yl)-3-(2H-tetrazol-5- yl)benzene-1,2-disulfonamide::US10221163, Example 475::US10544130, Example 475 Metallo-beta-lactamase type 2 0.130 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361318 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361318&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311834 386400706 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 714319 NCCNS(=O)(=O)c1ccc(-c2ccc3sc(CN)nc3c2)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C17H19N9O4S3/c18-5-6-21-33(29,30)13-4-2-10(9-1-3-12-11(7-9)22-14(8-19)31-12)15(16(13)32(20,27)28)17-23-25-26-24-17/h1-4,7,21H,5-6,8,18-19H2,(H2,20,27,28)(H,23,24,25,26) OYHMXKMDUJOANP-UHFFFAOYSA-N 361319 N1-(2-aminoethyl)-4-(2- (aminomethyl)benzo[d]thiazol- 5-yl)-3-(2H-tetrazol-5- yl)benzene-1,2-disulfonamide::US10221163, Example 476::US10544130, Example 476 Metallo-beta-lactamase type 2 0.281 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361319 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361319&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311115 386400707 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 714322 Cc1cc(cnc1N)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)NC[C@H](O)CN 361320 (R)—N1-(3-amino-2-hydroxypropyl)-4-(6-amino-5-methylpyridin-3-yl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 477::US10544130, Example 477 Metallo-beta-lactamase type 2 0.842 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361320 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361320&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311930 386400708 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 714325 NC[C@@H](O)CNS(=O)(=O)c1ccc(-c2cnc(N)c(F)c2)c(-c2nn[nH]n2)c1S(N)(=O)=O 361321 (R)-N1-(3-amino-2- hydroxypropyl)-4-(6-amino-5- fluoropyridin-3-yl)-3-(2H- tetrazol-5-yl)benzene-1,2- disulfonamide::US10221163, Example 478::US10544130, Example 478 Metallo-beta-lactamase type 2 0.677 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361321 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361321&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311805 386400709 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 714328 C[C@H](N)CNS(=O)(=O)c1ccc(-c2ccc(N)nc2)c(-c2nn[nH]n2)c1S(N)(=O)=O 361322 (S)—N1-(2-aminopropyl)-4-(6-aminopyridin-3-yl)-3-(2H-tetrazol-5-yl) benzene-1,2-disulfonamide::US10221163, Example 479::US10544130, Example 479 Metallo-beta-lactamase type 2 0.664 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361322 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361322&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124158361 386400710 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 714331 C[C@@H](N)CNS(=O)(=O)c1ccc(-c2ccc(N)nc2)c(-c2nn[nH]n2)c1S(N)(=O)=O 361323 (R)—N1-(2-aminopropyl)-4-(6-aminopyridin-3-yl)-3-(2H-tetrazol-5-yl) benzene-1,2-disulfonamide::US10221163, Example 480::US10544130, Example 480 Metallo-beta-lactamase type 2 0.320 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361323 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361323&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311058 386400711 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 714334 NS(=O)(=O)c1c(ccc(-c2cccc3[nH]cnc23)c1-c1nn[nH]n1)S(=O)(=O)NC[C@H]1CNCCN1 InChI=1S/C19H20N10O4S2/c20-34(30,31)18-15(35(32,33)25-9-11-8-21-6-7-22-11)5-4-12(16(18)19-26-28-29-27-19)13-2-1-3-14-17(13)24-10-23-14/h1-5,10-11,21-22,25H,6-9H2,(H2,20,30,31)/b13-12+/t11-/m1/s1 WHSKQSMNKQWZCL-GXZRWPEMSA-N 361324 (R)-4-(1H-benzo[d]imidazol-4- yl)-N1-(piperazin-2-ylmethyl)- 3-(1H-tetrazol-5-yl)benzene- 1,2-disulfonamide::US10221163, Example 481::US10544130, Example 481 Metallo-beta-lactamase type 2 0.251 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361324 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361324&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311045 386400712 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 714337 NCCNCCNS(=O)(=O)c1ccc(-c2ccc(N)nc2)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C16H22N10O4S2/c17-5-6-20-7-8-22-32(29,30)12-3-2-11(10-1-4-13(18)21-9-10)14(15(12)31(19,27)28)16-23-25-26-24-16/h1-4,9,20,22H,5-8,17H2,(H2,18,21)(H2,19,27,28)(H,23,24,25,26) IRSQPGJWCQJGBA-UHFFFAOYSA-N 361325 N1-(2-(-2-amineoethylamino)ethyl)-4-(6-aminopyridin-3-yl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 482::US10544130, Example 482 Metallo-beta-lactamase type 2 1.14 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361325 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361325&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124158549 386400713 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 714340 N[C@H]1CC(C1)NS(=O)(=O)c1ccc(-c2ccc(N)nc2)c(-c2nn[nH]n2)c1S(N)(=O)=O 361326 N1-((1R,3R)-3- aminocyclobutyl)-4-(6- aminopyridin-3-yl)-3-(2H- tetrazol-5-yl)benzene-1,2- disulfonamide::US10221163, Example 483::US10544130, Example 483 Metallo-beta-lactamase type 2 0.330 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361326 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361326&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311404 386400714 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713545 Nc1ccc(cn1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)NCCc1ncc[nH]1 InChI=1S/C17H18N10O4S2/c18-13-4-1-10(9-22-13)11-2-3-12(33(30,31)23-6-5-14-20-7-8-21-14)16(32(19,28)29)15(11)17-24-26-27-25-17/h1-4,7-9,23H,5-6H2,(H2,18,22)(H,20,21)(H2,19,28,29)(H,24,25,26,27) BLGYKMGOMSKCTK-UHFFFAOYSA-N 361061 N1-(2-(1H-imidazol-2-yl)ethyl)-4-(6-aminopyridin-3-yl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 218::US10544130, Example 218 Metallo-beta-lactamase type 2 0.694 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361061 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361061&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269222 386400451 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713548 Nc1cncc(c1)-c1ccc(SN[C@@H]2CCNC2)c(c1-c1nn[nH]n1)S(N)(=O)=O 361062 (R)-4-(5-aminopyridin-3-yl)-N1-(pyrrolidin-3-yl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 219 Metallo-beta-lactamase type 2 1.93 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361062 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361062&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 137537669 386400452 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713551 NS(=O)(=O)c1c(ccc(-c2cccnc2N2CCNCC2)c1-c1nn[nH]n1)S(=O)(=O)N[C@@H]1CCNC1 InChI=1S/C20H26N10O4S2/c21-35(31,32)18-16(36(33,34)27-13-5-7-23-12-13)4-3-14(17(18)19-25-28-29-26-19)15-2-1-6-24-20(15)30-10-8-22-9-11-30/h1-4,6,13,22-23,27H,5,7-12H2,(H2,21,31,32)(H,25,26,28,29)/t13-/m1/s1 FXKBDOWBFUHQLK-CYBMUJFWSA-N 361063 (R)-4-(2-(piperazin-1-yl)pyridin-3-yl)-N1-(pyrrolidin-3-yl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 220::US10544130, Example 220 Metallo-beta-lactamase type 2 35.8 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361063 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361063&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135310701 386400453 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713554 C[C@H](CN)NS(=O)(=O)c1ccc(-c2cncc(N)c2)c(-c2nn[nH]n2)c1S(N)(=O)=O 361064 (R)—N1-(1-aminopropan-2-yl)-4-(5-aminopyridin-3-yl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 221::US10544130, Example 221 Metallo-beta-lactamase type 2 0.688 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361064 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361064&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135310837 386400454 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713557 NC[C@H](O)CNS(=O)(=O)c1ccc(-c2ccncc2N)c(-c2nn[nH]n2)c1S(N)(=O)=O 361065 (S)—N1-(3-amino-2-hydroxypropyl)-4-(3-aminopyridin-4-yl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 222::US10544130, Example 222 Metallo-beta-lactamase type 2 1.19 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361065 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361065&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311612 386400455 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713560 NC[C@H](N)CNS(=O)(=O)c1ccc(-c2cnccc2N)c(-c2nn[nH]n2)c1S(N)(=O)=O 361066 N4-(2-aminoethyl)-2-(2H-tetrazol-5-yl)-3'-(1H-1,2,4-triazol-3-yl)-[1,1'-biphenyl]-3,4-disulfonamide::US10221163, Example 223::US10544130, Example 223 Metallo-beta-lactamase type 2 4.51 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361066 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361066&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311691 386400456 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713563 NCCNS(=O)(=O)c1ccc(-c2cccc(c2)-c2nc[nH]n2)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C17H18N10O4S2/c18-6-7-22-33(30,31)13-5-4-12(10-2-1-3-11(8-10)16-20-9-21-23-16)14(15(13)32(19,28)29)17-24-26-27-25-17/h1-5,8-9,22H,6-7,18H2,(H2,19,28,29)(H,20,21,23)(H,24,25,26,27) HRAZYWVUQCSJIG-UHFFFAOYSA-N 361067 N4-(2-aminoethyl)-2-(2H-tetrazol-5-yl)-3′-(1H-1,2,4-triazol-3-yl)-[1,1′-biphenyl]-3,4-disulfonamide::US10221163, Example 224::US10544130, Example 224 Metallo-beta-lactamase type 2 0.412 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361067 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361067&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124158508 386400457 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713566 NS(=O)(=O)c1c(ccc(-c2cccc(c2)-c2nc[nH]n2)c1-c1nn[nH]n1)S(=O)(=O)N[C@@H]1CCNC1 InChI=1S/C19H20N10O4S2/c20-34(30,31)17-15(35(32,33)27-13-6-7-21-9-13)5-4-14(16(17)19-25-28-29-26-19)11-2-1-3-12(8-11)18-22-10-23-24-18/h1-5,8,10,13,21,27H,6-7,9H2,(H2,20,30,31)(H,22,23,24)(H,25,26,28,29)/t13-/m1/s1 QHJWADHROHWYDE-CYBMUJFWSA-N 361068 (R)-N4-(pyrrolidin-3-yl)-2-(2H- tetrazol-5-yl)-3'-(1H-1,2,4-triazol-3- yl)-[1,1'-biphenyl]-3,4-disulfonamide::US10221163, Example 225::US10544130, Example 225 Metallo-beta-lactamase type 2 0.110 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361068 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361068&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311683 386400458 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713569 N[C@@H](CO)CNS(=O)(=O)c1ccc(-c2cccc(c2)C2N=CN=N2)c(-c2nn[nH]n2)c1S(N)(=O)=O 361069 N4-((R)-2-amino-3-hydroxypropyl)- 2-(2H-tetrazol-5-yl)-3'-(3H-1,2,4- triazol-3-yl)-[1,1'-biphenyl]-3,4- disulfonamide::US10221163, Example 226::US10544130, Example 226 Metallo-beta-lactamase type 2 3.24 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361069 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361069&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311189 386400459 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713572 NCC(CN)NS(=O)(=O)c1ccc(-c2cccc(c2)-c2nc[nH]n2)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C18H21N11O4S2/c19-7-12(8-20)27-35(32,33)14-5-4-13(10-2-1-3-11(6-10)17-22-9-23-24-17)15(16(14)34(21,30)31)18-25-28-29-26-18/h1-6,9,12,27H,7-8,19-20H2,(H2,21,30,31)(H,22,23,24)(H,25,26,28,29) TVOOVNFXLKCVSE-UHFFFAOYSA-N 361070 N4-(1,3-diaminopropan-2-yl)-2- (2H-tetrazol-5-yl)-3'-(1H-1,2,4- triazol-3-yl)-[1,1'-biphenyl]-3,4- disulfonamide::US10221163, Example 227::US10544130, Example 227 Metallo-beta-lactamase type 2 0.165 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361070 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361070&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269223 386400460 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713575 NCCNS(=O)(=O)c1ccc(-c2cccc(c2)-c2n[nH]c(N)n2)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C17H19N11O4S2/c18-6-7-21-34(31,32)12-5-4-11(13(14(12)33(20,29)30)16-24-27-28-25-16)9-2-1-3-10(8-9)15-22-17(19)26-23-15/h1-5,8,21H,6-7,18H2,(H2,20,29,30)(H3,19,22,23,26)(H,24,25,27,28) TXXWCRQWLDPAJM-UHFFFAOYSA-N 361071 3'-(5-amino-1H-1,2,4-triazol-3-yl)- N4-(2-aminoethyl)-2-(2H-tetrazol-5- yl)-[1,1'-biphenyl]-3,4- disulfonamide::US10221163, Example 228::US10544130, Example 228 Metallo-beta-lactamase type 2 0.562 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361071 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361071&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269224 386400461 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713578 NCC(CN)NS(=O)(=O)c1ccc(-c2cccc(c2)C2N=NC(N)=N2)c(-c2nn[nH]n2)c1S(N)(=O)=O 361072 3'-(5-amino-3H-1,2,4-triazol-3-yl)- N4-(1,3-diaminopropan-2-yl)-2- (2H-tetrazol-5-yl)-[1,1'-biphenyl]- 3,4-disulfonamide::US10221163, Example 229::US10544130, Example 229 Metallo-beta-lactamase type 2 0.173 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361072 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361072&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311238 386400462 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713581 NC[C@@H](N)CNS(=O)(=O)c1ccc(-c2cccc(c2)-c2n[nH]c(N)n2)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C18H22N12O4S2/c19-7-11(20)8-23-36(33,34)13-5-4-12(14(15(13)35(22,31)32)17-26-29-30-27-17)9-2-1-3-10(6-9)16-24-18(21)28-25-16/h1-6,11,23H,7-8,19-20H2,(H2,22,31,32)(H3,21,24,25,28)(H,26,27,29,30)/t11-/m1/s1 HRKNTWMNDJWRNZ-LLVKDONJSA-N 361073 (R)-3'-(5-amino-1H-1,2,4-triazol-3- yl)-N4-(2,3-diaminopropyl)-2-(2H- tetrazol-5-yl)-[1,1'-biphenyl]-3,4- disulfonamide::US10221163, Example 230::US10544130, Example 230 Metallo-beta-lactamase type 2 0.357 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361073 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361073&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311364 386400463 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713584 Nc1nc(n[nH]1)-c1cccc(c1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)N[C@@H]1CCNC1 InChI=1S/C19H21N11O4S2/c20-19-23-17(24-27-19)11-3-1-2-10(8-11)13-4-5-14(36(33,34)28-12-6-7-22-9-12)16(35(21,31)32)15(13)18-25-29-30-26-18/h1-5,8,12,22,28H,6-7,9H2,(H2,21,31,32)(H3,20,23,24,27)(H,25,26,29,30)/t12-/m1/s1 IIUCDOABIKQJOU-GFCCVEGCSA-N 361074 (R)-3'-(5-amino-1H-1,2,4-triazol-3- yl)-N4-(pyrrolidin-3-yl)-2-(2H- tetrazol-5-yl)-[1,1'-biphenyl]-3,4- disulfonamide::US10221163, Example 231::US10544130, Example 231 Metallo-beta-lactamase type 2 0.376 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361074 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361074&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311825 386400464 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713587 CN1CC[C@H](C1)NS(=O)(=O)c1ccc(-c2cccc3[nH]c(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C19H20N10O4S2/c1-29-8-7-10(9-29)26-35(32,33)14-6-5-11(12-3-2-4-13-16(12)23-19(20)22-13)15(17(14)34(21,30)31)18-24-27-28-25-18/h2-6,10,26H,7-9H2,1H3,(H2,20,22)(H2,21,30,31)/b12-11+/t10-/m1/s1 QSRDUBJBQHZFPR-PJSNMCHCSA-N 361075 (R)-4-(2-amino-1H-benzo[d]imidazol-4-yl)-N1-(1-methylpyrrolidin-3-yl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 232::US10544130, Example 232 Metallo-beta-lactamase type 2 0.609 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361075 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361075&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124158391 386400465 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713590 C[N]1(C)CC[C@H](C1)NS(=O)(=O)c1ccc(-c2cccc3[nH]c(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C20H23N10O4S2/c1-30(2)9-8-11(10-30)27-36(33,34)15-7-6-12(13-4-3-5-14-17(13)24-20(21)23-14)16(18(15)35(22,31)32)19-25-28-29-26-19/h3-7,11,27H,8-10H2,1-2H3,(H2,21,23)(H2,22,31,32)/b13-12+/t11-/m1/s1 YMBSYOSFIYTLEM-GXZRWPEMSA-N 361076 (R)-3-((4-(2-amino-1H-benzo[d]imidazol-4-yl)-2-sulfamoyl-3-(2H-tetrazol-5-yl)phenyl)sulfonamido)-1,1-dimethylpyrrolidin-1-ium chloride::US10221163, Example 233::US10544130, Example 233 Metallo-beta-lactamase type 2 0.305 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361076 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361076&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311462 386400466 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713593 Nc1nc2c(cc(I)cc2[nH]1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)N[C@@H]1CCNC1 InChI=1S/C18H17IN10O4S2/c19-8-5-11(15-12(6-8)23-18(20)24-15)10-1-2-13(35(32,33)27-9-3-4-22-7-9)16(34(21,30)31)14(10)17-25-28-29-26-17/h1-2,5-6,9,22,27H,3-4,7H2,(H2,20,23)(H2,21,30,31)/b11-10+/t9-/m1/s1 OKNVYQOHMDWUOT-HNLKAFMCSA-N 361077 (R)-4-(2-amino-6-iodo-1H-benzo[d]imidazol-4-yl)-N1-(pyrrolidin-3-yl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 234::US10544130, Example 234 Metallo-beta-lactamase type 2 0.140 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361077 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361077&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124158402 386400467 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713596 NS(=O)(=O)c1c(ccc(-c2cccc3[nH]nnc23)c1-c1nn[nH]n1)S(=O)(=O)N[C@@H]1CCNC1 InChI=1S/C17H16N10O4S2/c18-32(28,29)16-13(33(30,31)24-9-6-7-19-8-9)5-4-10(14(16)17-22-26-27-23-17)11-2-1-3-12-15(11)21-25-20-12/h1-5,9,19,24H,6-8H2,(H2,18,28,29)/b11-10+/t9-/m1/s1 ARXOIEPQNDOAMQ-HNLKAFMCSA-N 361078 (R)-4-(1H-benzo[d][1,2,3]triazol-4-yl)-N1-(pyrrolidin-3-yl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 235::US10544130, Example 235 Metallo-beta-lactamase type 2 0.440 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361078 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361078&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135310991 386400468 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713599 NCCNS(=O)(=O)c1ccc(-c2cccc3[nH]nnc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C15H16N10O4S2/c16-6-7-18-31(28,29)11-5-4-8(9-2-1-3-10-13(9)20-23-19-10)12(14(11)30(17,26)27)15-21-24-25-22-15/h1-5,18H,6-7,16H2,(H2,17,26,27)(H,19,20,23)(H,21,22,24,25) QCEPJZBJONEUOB-UHFFFAOYSA-N 361079 US10221163, Example 236::US10544130, Example 236 Metallo-beta-lactamase type 2 0.544 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361079 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361079&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 137537549 386400469 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713602 C[C@H](CN)NS(=O)(=O)c1ccc(-c2cccc3[nH]nnc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C16H16N10O4S2/c1-8(7-17)23-32(29,30)12-6-5-9(10-3-2-4-11-14(10)20-24-19-11)13(15(12)31(18,27)28)16-21-25-26-22-16/h2-6,8,23H,7,17H2,1H3,(H2,18,27,28)/b10-9+/t8-/m1/s1 UGWOIILZSOTQMM-KGSKPCQNSA-N 361080 US10221163, Example 237::US10544130, Example 237 Metallo-beta-lactamase type 2 0.120 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361080 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361080&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 137537516 386400470 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 714343 Nc1ccc(cn1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)NCC1CCNC1 361327 (S)-4-(6-aminopyridin-3- yl)-N1-(pyrrolidin-3- ylmethyl)-3-(2H-tetrazol- 5-yl)benzene-1,2- disulfonamide::US10221163, Example 484::US10544130, Example 484 Metallo-beta-lactamase type 2 0.248 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361327 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361327&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311095 386400715 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 714346 Nc1ccc(cn1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)N1CCNCC1 InChI=1S/C16H19N9O4S2/c17-13-4-1-10(9-20-13)11-2-3-12(31(28,29)25-7-5-19-6-8-25)15(30(18,26)27)14(11)16-21-23-24-22-16/h1-4,9,19H,5-8H2,(H2,17,20)(H2,18,26,27)(H,21,22,23,24) KCGYMVKIHZQNLT-UHFFFAOYSA-N 361328 3-(6-aminopyridin-3-yl)- 6-(piperazin-1- ylsulfonyl)-2-(2H- tetrazol-5- yl)benzenesulfonamide::US10221163, Example 485::US10544130, Example 485 Metallo-beta-lactamase type 2 3.58 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361328 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361328&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311532 386400716 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 714349 NC[C@]1(CCNC1)NS(=O)(=O)c1ccc(-c2ccc(N)nc2)c(-c2nn[nH]n2)c1S(N)(=O)=O 361329 (R)-N1-(3- (aminomethyl)pyrrolidin- 3-yl)-4-(6-aminopyridin- 3-yl)-3-(2H-tetrazol-5- yl)benzene-1,2- disulfonamide dihydrochloride::US10221163, Example 486::US10221163, Example 487::US10544130, Example 487 Metallo-beta-lactamase type 2 0.422 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361329 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361329&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311895 386400717 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 714352 NC[C@]1(CCNC1)NS(=O)(=O)c1ccc(-c2ccc(N)nc2)c(-c2nn[nH]n2)c1S(N)(=O)=O 361329 (R)-N1-(3- (aminomethyl)pyrrolidin- 3-yl)-4-(6-aminopyridin- 3-yl)-3-(2H-tetrazol-5- yl)benzene-1,2- disulfonamide dihydrochloride::US10221163, Example 486::US10221163, Example 487::US10544130, Example 487 Metallo-beta-lactamase type 2 0.803 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361329 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361329&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311895 386400717 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 714355 Nc1ccc(cn1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)NC[C@@H]1CCCN1 361331 (S)-4-(6-aminopyridin-3- yl)-N1-(pyrrolidin-2- ylmethyl)-3-(2H-tetrazol- 5-yl)benzene-1,2- disulfonamide::US10221163, Example 488::US10544130, Example 488 Metallo-beta-lactamase type 2 0.355 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361331 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361331&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135310856 386400718 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 714358 Nc1ccc(cn1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)NC[C@H]1CCCN1 361332 (R)-4-(6-aminopyridin-3- yl)-N1-(pyrrolidin-2- ylmethyl)-3-(2H-tetrazol- 5-yl)benzene-1,2- disulfonamide::US10221163, Example 489::US10544130, Example 489 Metallo-beta-lactamase type 2 0.566 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361332 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361332&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311625 386400719 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 714361 Nc1ccc(cn1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)N[C@@H]1CCCNC1 361333 (R)-4-(6-aminopyridin-3- yl)-N1-(piperidin-3-yl)-3- (2H-tetrazol-5- yl)benzene-1,2- disulfonamide::US10221163, Example 490::US10544130, Example 490 Metallo-beta-lactamase type 2 0.176 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361333 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361333&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311042 386400720 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 714364 Nc1ccc(cn1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)NC[C@@H]1CCNC1 361334 (R)-4-(6-aminopyridin-3- yl)-N1-(pyrrolidin-3- ylmethyl)-3-(2H-tetrazol- 5-yl)benzene-1,2- disulfonamide::US10221163, Example 491::US10544130, Example 491 Metallo-beta-lactamase type 2 0.271 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361334 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361334&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311092 386400721 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 714367 Nc1ccc(cn1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)NCC1(O)CCNCC1 InChI=1S/C18H23N9O5S2/c19-14-4-1-11(9-22-14)12-2-3-13(16(33(20,29)30)15(12)17-24-26-27-25-17)34(31,32)23-10-18(28)5-7-21-8-6-18/h1-4,9,21,23,28H,5-8,10H2,(H2,19,22)(H2,20,29,30)(H,24,25,26,27) YUFZAQCMPXKUOU-UHFFFAOYSA-N 361335 4-(6-aminopyridin-3-yl)- N1-((4-hydroxypiperidin- 4-yl)methyl)-3-(2H- tetrazol-5-yl)benzene-1,2 disulfonamide::US10221163, Example 492::US10544130, Example 492 Metallo-beta-lactamase type 2 0.520 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361335 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361335&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311793 386400722 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 714370 Nc1ccc(cn1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)NC1CNC1 InChI=1S/C15H17N9O4S2/c16-12-4-1-8(5-19-12)10-2-3-11(30(27,28)22-9-6-18-7-9)14(29(17,25)26)13(10)15-20-23-24-21-15/h1-5,9,18,22H,6-7H2,(H2,16,19)(H2,17,25,26)(H,20,21,23,24) LETKBQVLHMERPP-UHFFFAOYSA-N 361336 4-(6-aminopyridin-3-yl)- N1-(azetidin-3-yl)-3-(2H- tetrazol-5-yl)benzene-1,2- disulfonamide::US10221163, Example 493::US10544130, Example 493 Metallo-beta-lactamase type 2 0.403 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361336 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361336&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311301 386400723 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 714373 Nc1ccc(cn1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)N[C@H]1CCCNC1 361337 (S)-4-(6-aminopyridin-3- yl)-N1-(piperidin-3-yl)-3- (2H-tetrazol-5- yl)benzene-1,2- disulfonamide::US10221163, Example 494::US10544130, Example 494 Metallo-beta-lactamase type 2 0.808 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361337 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361337&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311057 386400724 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 714376 Nc1ccc(cn1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)NCC1(O)CNC1 InChI=1S/C16H19N9O5S2/c17-12-4-1-9(5-20-12)10-2-3-11(32(29,30)21-8-16(26)6-19-7-16)14(31(18,27)28)13(10)15-22-24-25-23-15/h1-5,19,21,26H,6-8H2,(H2,17,20)(H2,18,27,28)(H,22,23,24,25) ZULUBCFYHQEBJW-UHFFFAOYSA-N 361338 4-(6-aminopyridin-3-yl)- N1-((3-hydroxyazetidin-3- yl)methyl)-3-(2H-tetrazol- 5-yl)benzene-1,2- disulfonamide::US10221163, Example 495::US10544130, Example 495 Metallo-beta-lactamase type 2 0.328 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361338 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361338&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135310686 386400725 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 714379 NCCCNS(=O)(=O)c1ccc(-c2ccc(N)nc2)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C15H19N9O4S2/c16-6-1-7-20-30(27,28)11-4-3-10(9-2-5-12(17)19-8-9)13(14(11)29(18,25)26)15-21-23-24-22-15/h2-5,8,20H,1,6-7,16H2,(H2,17,19)(H2,18,25,26)(H,21,22,23,24) PFGLEWSOALRQSL-UHFFFAOYSA-N 361339 N1-(3-aminopropyl)-4-(6- aminopyridin-3-yl)-3-(2H- tetrazol-5-yl)benzene-1,2- disulfonamide hydrogen chloride::US10221163, Example 496::US10544130, Example 496 Metallo-beta-lactamase type 2 0.576 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361339 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361339&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311929 386400726 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 714382 CC1(CNC1)NS(=O)(=O)c1ccc(-c2ccc(N)nc2)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C16H19N9O4S2/c1-16(7-19-8-16)23-31(28,29)11-4-3-10(9-2-5-12(17)20-6-9)13(14(11)30(18,26)27)15-21-24-25-22-15/h2-6,19,23H,7-8H2,1H3,(H2,17,20)(H2,18,26,27)(H,21,22,24,25) HGICSZSMZDNVQQ-UHFFFAOYSA-N 361340 4-(6-aminopyridin-3-yl)- 1-N-(3-methylazetidin-3- yl)-3-(2H-1,2,3,4-tetrazol- 5-yl)benzene-1,2- disulfonamide hydrogen::US10221163, Example 497::US10544130, Example 497 Metallo-beta-lactamase type 2 0.645 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361340 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361340&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 137537629 386400727 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 714385 C[C@H](CCN)NS(=O)(=O)c1ccc(-c2ccc(N)nc2)c(-c2nn[nH]n2)c1S(N)(=O)=O 361341 (R)-N1-(4-aminobutan-2- yl)-4-(6-aminopyridin-3- yl)-3-(1H-tetrazol-5- yl)benzene-1,2- disulfonamide::US10221163, Example 498::US10544130, Example 498 Metallo-beta-lactamase type 2 0.076 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361341 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361341&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311649 386400728 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 714388 C[C@@H](CCN)NS(=O)(=O)c1ccc(-c2ccc(N)nc2)c(-c2nn[nH]n2)c1S(N)(=O)=O 361342 (S)-N1-(4-aminobutan-2- yl)-4-(6-aminopyridin-3- yl)-3-(1H-tetrazol-5- yl)benzene-1,2- disulfonamide::US10221163, Example 499::US10544130, Example 499 Metallo-beta-lactamase type 2 1.02 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361342 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361342&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311453 386400729 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 714391 NCCN1CC[C@H](C1)NS(=O)(=O)c1ccc(-c2ccc(N)nc2)c(-c2nn[nH]n2)c1S(N)(=O)=O 361343 (R)—N1-(1-(2-aminoethyl)pyrrolidin-3-yl)-4-(6-aminopyridin-3-yl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 500 Metallo-beta-lactamase type 2 0.164 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361343 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361343&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311397 386400730 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713605 NS(=O)(=O)c1c(ccc(-c2cccc3nonc23)c1-c1nn[nH]n1)S(=O)(=O)N[C@@H]1CCNC1 361081 US10221163, Example 238::US10544130, Example 238 Metallo-beta-lactamase type 2 0.800 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361081 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361081&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 137537548 386400471 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713608 NCCNS(=O)(=O)c1ccc(-c2cccc3nonc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C15H15N9O5S2/c16-6-7-18-31(27,28)11-5-4-8(9-2-1-3-10-13(9)22-29-21-10)12(14(11)30(17,25)26)15-19-23-24-20-15/h1-5,18H,6-7,16H2,(H2,17,25,26)(H,19,20,23,24) PQOCNUYHZWCRFU-UHFFFAOYSA-N 361082 US10221163, Example 239::US10544130, Example 239 Metallo-beta-lactamase type 2 1.06 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361082 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361082&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 137537721 386400472 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713611 N[C@H]1CNC[C@H]1NS(=O)(=O)c1ccc(-c2cccc3[nH]c(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C18H19N11O4S2/c19-10-6-22-7-12(10)27-35(32,33)13-5-4-8(9-2-1-3-11-15(9)24-18(20)23-11)14(16(13)34(21,30)31)17-25-28-29-26-17/h1-5,10,12,22,27H,6-7,19H2,(H2,20,23)(H2,21,30,31)/b9-8+/t10-,12+/m0/s1 LIRUKQKKERNVIK-SEOINYINSA-N 361083 US10221163, Example 240::US10544130, Example 240 Metallo-beta-lactamase type 2 0.745 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361083 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361083&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 137537546 386400473 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713614 N[C@@H]1CNC[C@@H]1NS(=O)(=O)c1ccc(-c2cccc3[nH]c(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C18H19N11O4S2/c19-10-6-22-7-12(10)27-35(32,33)13-5-4-8(9-2-1-3-11-15(9)24-18(20)23-11)14(16(13)34(21,30)31)17-25-28-29-26-17/h1-5,10,12,22,27H,6-7,19H2,(H2,20,23)(H2,21,30,31)/b9-8+/t10-,12+/m1/s1 LIRUKQKKERNVIK-QMTFQVMMSA-N 361084 US10221163, Example 241::US10544130, Example 241 Metallo-beta-lactamase type 2 0.738 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361084 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361084&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311108 386400474 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713617 CNc1ccc(cn1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)N[C@@H]1CCNC1 361085 US10221163, Example 242::US10544130, Example 242 Metallo-beta-lactamase type 2 0.157 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361085 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361085&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 137537584 386400475 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713620 CNc1ccc(cn1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)NCCN InChI=1S/C15H19N9O4S2/c1-18-12-5-2-9(8-19-12)10-3-4-11(30(27,28)20-7-6-16)14(29(17,25)26)13(10)15-21-23-24-22-15/h2-5,8,20H,6-7,16H2,1H3,(H,18,19)(H2,17,25,26)(H,21,22,23,24) XAJKORAMVRKLNB-UHFFFAOYSA-N 361086 US10221163, Example 243::US10544130, Example 243 Metallo-beta-lactamase type 2 0.312 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361086 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361086&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 137537652 386400476 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713623 CN([C@H]1CCNC1)S(=O)(=O)c1ccc(-c2cccc3[nH]c(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C19H20N10O4S2/c1-29(10-7-8-22-9-10)35(32,33)14-6-5-11(12-3-2-4-13-16(12)24-19(20)23-13)15(17(14)34(21,30)31)18-25-27-28-26-18/h2-6,10,22H,7-9H2,1H3,(H2,20,23)(H2,21,30,31)/b12-11+/t10-/m0/s1 DALLWTADFKBWSD-IUZMTQGWSA-N 361087 (S)-4-(2-amino-1H-benzo[d]imidazol-7-yl)-N1-methyl-N1-(pyrrolidin-3-yl)-3-(1H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 244::US10544130, Example 244 Metallo-beta-lactamase type 2 6.58 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361087 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361087&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135149999 386400477 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713626 C[N]1(C)CC(C1)NS(=O)(=O)c1ccc(-c2cccc3[nH]c(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C19H23N10O4S2/c1-29(2)8-10(9-29)26-35(32,33)14-7-6-11(12-4-3-5-13-16(12)23-19(20)22-13)15(17(14)34(21,30)31)18-24-27-28-25-18/h3-7,10,26H,8-9H2,1-2H3,(H3,20,22,23)(H2,21,30,31)(H,24,25,27,28) ONDWABQTTHVKDD-UHFFFAOYSA-N 361088 3-(4-(2-Amino-1H-benzo[d]imidazol-4-yl)-2-sulfamoyl-3-(2H-tetrazol-5-yl) phenylsulfonamido)-1,1-dimethylazetidin-1-ium hydrogencarbonate::US10221163, Example 245 Metallo-beta-lactamase type 2 1.14 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361088 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361088&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311254 386400478 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713629 NCCN1CC[C@H](C1)NS(=O)(=O)c1ccc(-c2cccc3[nH]c(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C20H23N11O4S2/c21-7-9-31-8-6-11(10-31)28-37(34,35)15-5-4-12(13-2-1-3-14-17(13)25-20(22)24-14)16(18(15)36(23,32)33)19-26-29-30-27-19/h1-5,11,28H,6-10,21H2,(H2,22,24)(H2,23,32,33)/b13-12+/t11-/m1/s1 WPTXVQKWHIQZFR-GXZRWPEMSA-N 361089 (R)-4-(2-amino-1H-benzo[d]imidazol-4-yl)-N1-(1-(2-aminoethyl) pyrrolidin-3-yl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 246::US10544130, Example 246 Metallo-beta-lactamase type 2 0.853 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361089 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361089&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135310877 386400479 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713632 NCC(CO)(CO)NS(=O)(=O)c1ccc(-c2cccc3[nH]c(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C18H22N10O6S2/c19-6-18(7-29,8-30)26-36(33,34)12-5-4-9(10-2-1-3-11-14(10)23-17(20)22-11)13(15(12)35(21,31)32)16-24-27-28-25-16/h1-5,26,29-30H,6-8,19H2,(H3,20,22,23)(H2,21,31,32)(H,24,25,27,28) KTHPBOABEUUPEP-UHFFFAOYSA-N 361090 4-(2-amino-1H-benzo[d]imidazol-4-yl)-N-1-(1-amino-3-hydroxy-2-(hydroxymethyl) propan-2-yl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 247::US10544130, Example 247 Metallo-beta-lactamase type 2 0.504 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361090 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361090&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311081 386400480 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713635 C[N]1(CCN)CC[C@@H](C1)NS(=O)(=O)c1ccc(-c2cccc3[nH]c(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C21H26N11O4S2/c1-32(10-8-22)9-7-12(11-32)29-38(35,36)16-6-5-13(14-3-2-4-15-18(14)26-21(23)25-15)17(19(16)37(24,33)34)20-27-30-31-28-20/h2-6,12,29H,7-11,22H2,1H3,(H2,23,25)(H2,24,33,34)/b14-13+/t12-/m0/s1 FUYNLYBAFQVTLQ-FWJVZWRSSA-N 361091 (3R)-3-{[4-(2-amino-1H-1,3-benzodiazol-4-yl)-2-sulfamoyl-3-(2H-1,2,3,4-tetrazol-5-yl)benzene]sulfonamido}-1-(2-aminoethyl)-1-methylpyrrolidin-1-ium; methaneperoxoate::US10221163, Example 248::US10544130, Example 249 Metallo-beta-lactamase type 2 0.147 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361091 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361091&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311041 386400481 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713638 C[N+]1(CCN)CC[C@@H](C1)NS(=O)(=O)c1ccc(-c2cccc3[nH]c(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C21H26N11O4S2/c1-32(10-8-22)9-7-12(11-32)29-38(35,36)16-6-5-13(14-3-2-4-15-18(14)26-21(23)25-15)17(19(16)37(24,33)34)20-27-30-31-28-20/h2-6,12,29H,7-11,22H2,1H3,(H2,23,25)(H2,24,33,34)/q+1/b14-13+/t12-,32?/m0/s1 IJLHELHLLCLSEM-WRWAFURQSA-N 361092 (3S)-3-{[4-(2-amino-1H-1,3-benzodiazol-4-yl)-2-sulfamoyl-3-(2H-1,2,3,4-tetrazol-5-yl)benzene]sulfonamido}-1-(2-aminoethyl)-1-methylpyrrolidin-1-ium methaneperoxoate::US10221163, Example 249 Metallo-beta-lactamase type 2 0.342 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361092 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361092&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311041 386400482 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713641 Nc1nc2c(cccc2[nH]1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)NC[C@]1(N)CCNC1 InChI=1S/C19H21N11O4S2/c20-18-25-12-3-1-2-11(15(12)26-18)10-4-5-13(36(33,34)24-9-19(21)6-7-23-8-19)16(35(22,31)32)14(10)17-27-29-30-28-17/h1-5,23-24H,6-9,21H2,(H2,20,25)(H2,22,31,32)/b11-10+/t19-/m0/s1 FHCSQKLNCSODLX-VYENPZKTSA-N 361093 (S)-4-(2-amino-1H-benzo[d]imidazol-4-yl)-N1-((3-aminopyrrolidin-3-yl)methyl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 250::US10544130, Example 250 Metallo-beta-lactamase type 2 0.513 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361093 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361093&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311019 386400483 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713644 Nc1nc2c(cccc2[nH]1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)NC[C@@]1(N)CCNC1 InChI=1S/C19H21N11O4S2/c20-18-25-12-3-1-2-11(15(12)26-18)10-4-5-13(36(33,34)24-9-19(21)6-7-23-8-19)16(35(22,31)32)14(10)17-27-29-30-28-17/h1-5,23-24H,6-9,21H2,(H2,20,25)(H2,22,31,32)/b11-10+/t19-/m1/s1 FHCSQKLNCSODLX-GNISGLHKSA-N 361094 (R)-4-(2-amino-1H-benzo[d]imidazol-4-yl)-N1-((3-aminopyrrolidin-3-yl)methyl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 251::US10544130, Example 251 Metallo-beta-lactamase type 2 0.755 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361094 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361094&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311629 386400484 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713647 Nc1nc2c(cccc2[nH]1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)NC1CNC1 InChI=1S/C17H18N10O4S2/c18-17-21-11-3-1-2-10(14(11)22-17)9-4-5-12(33(30,31)25-8-6-20-7-8)15(32(19,28)29)13(9)16-23-26-27-24-16/h1-5,8,20,25H,6-7H2,(H3,18,21,22)(H2,19,28,29)(H,23,24,26,27) CJGHWHVRPSCRKH-UHFFFAOYSA-N 361095 4-(2-amino-1H- benzo[d]imidazol-4-yl)-N1- (azetidin-3-yl)-3-(2H-tetrazol-5- yl)benzene-1,2-disulfonamide::US10221163, Example 252::US10544130, Example 252 Metallo-beta-lactamase type 2 0.654 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361095 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361095&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135310885 386400485 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713650 NC[C@H]1CCN(C1)S(=O)(=O)c1ccc(-c2cccc3[nH]c(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C19H20N10O4S2/c20-8-10-6-7-29(9-10)35(32,33)14-5-4-11(12-2-1-3-13-16(12)24-19(21)23-13)15(17(14)34(22,30)31)18-25-27-28-26-18/h1-5,10H,6-9,20H2,(H2,21,23)(H2,22,30,31)/b12-11+/t10-/m1/s1 XRAJNWIJZHZXAC-PJSNMCHCSA-N 361096 (R)-3-(2-amino-1H-benzo[d] imidazol-4-yl)-6-((3- (aminomethyl)pyrrolidin-1- yl)sulfonyl)-2-(2H-tetrazol-5- yl)benzenesulfonamide::US10221163, Example 253::US10544130, Example 253 Metallo-beta-lactamase type 2 2.68 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361096 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361096&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311473 386400486 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713653 NC[C@@H]1CCN(C1)S(=O)(=O)c1ccc(-c2cccc3[nH]c(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C19H20N10O4S2/c20-8-10-6-7-29(9-10)35(32,33)14-5-4-11(12-2-1-3-13-16(12)24-19(21)23-13)15(17(14)34(22,30)31)18-25-27-28-26-18/h1-5,10H,6-9,20H2,(H2,21,23)(H2,22,30,31)/b12-11+/t10-/m0/s1 XRAJNWIJZHZXAC-IUZMTQGWSA-N 361097 (S)-4-(2-amino-1H- benzo[d]imidazol-7-yl)-N1- methyl-N1-(pyrrolidin-3-yl)-3- (1H-tetrazol-5-yl)benzene-1,2- disulfonamide::US10221163, Example 254::US10544130, Example 254 Metallo-beta-lactamase type 2 2.13 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361097 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361097&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 137537583 386400487 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713656 CN(C1CNC1)S(=O)(=O)c1ccc(-c2cccc3[nH]c(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C18H20N10O4S2/c1-28(9-7-21-8-9)34(31,32)13-6-5-10(11-3-2-4-12-15(11)23-18(19)22-12)14(16(13)33(20,29)30)17-24-26-27-25-17/h2-6,9,21H,7-8H2,1H3,(H3,19,22,23)(H2,20,29,30)(H,24,25,26,27) YJLWZMRIPUTANI-UHFFFAOYSA-N 361098 4-(2-amino-1H- benzo[d]imidazol-4-yl)-N1- (azetidin-3-yl)-N1-methyl-3- (2H-tetrazol-5-yl)benzene-1,2- disulfonamide::US10221163, Example 255::US10544130, Example 255 Metallo-beta-lactamase type 2 2.84 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361098 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361098&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135310714 386400488 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713659 CN1CC(C1)NS(=O)(=O)c1ccc(-c2cccc3[nH]c(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C18H20N10O4S2/c1-28-7-9(8-28)25-34(31,32)13-6-5-10(11-3-2-4-12-15(11)22-18(19)21-12)14(16(13)33(20,29)30)17-23-26-27-24-17/h2-6,9,25H,7-8H2,1H3,(H3,19,21,22)(H2,20,29,30)(H,23,24,26,27) NEVMFJXLRZQHHL-UHFFFAOYSA-N 361099 4-(2-amino-1H- benzo[d]imidazol-4-yl)-N1-(1- methylazetidin-3-yl)-3-(2H- tetrazol-5-yl)benzene-1,2- disulfonamide::US10221163, Example 256::US10544130, Example 256 Metallo-beta-lactamase type 2 0.609 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361099 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361099&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135310783 386400489 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713662 CC1(CNC1)NS(=O)(=O)c1ccc(-c2cccc3[nH]c(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C18H20N10O4S2/c1-18(7-21-8-18)26-34(31,32)12-6-5-9(10-3-2-4-11-14(10)23-17(19)22-11)13(15(12)33(20,29)30)16-24-27-28-25-16/h2-6,21,26H,7-8H2,1H3,(H3,19,22,23)(H2,20,29,30)(H,24,25,27,28) YQHBXQCEAXBCEQ-UHFFFAOYSA-N 361100 4-(2-amino-1H- benzo[d]imidazol-4-yl)-N1-(3- methylazetidin-3-yl)-3-(2H- tetrazol-5-ylbenzene-1,2- disulfonamide::US10221163, Example 257::US10544130, Example 257 Metallo-beta-lactamase type 2 0.642 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361100 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361100&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135310827 386400490 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713665 NCCCCNS(=O)(=O)c1ccc(-c2cccc3[nH]c(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C18H22N10O4S2/c19-8-1-2-9-22-34(31,32)13-7-6-10(11-4-3-5-12-15(11)24-18(20)23-12)14(16(13)33(21,29)30)17-25-27-28-26-17/h3-7,22H,1-2,8-9,19H2,(H3,20,23,24)(H2,21,29,30)(H,25,26,27,28) MOMXDEZGVCWDGR-UHFFFAOYSA-N 361101 4-(2-amino-1H- benzo[d]imidazol-7-yl)-N1-(4- aminobutyl)-3-(2H-tetrazol-5- yl)benzene-1,2-disulfonamide::US10221163, Example 258::US10544130, Example 258 Metallo-beta-lactamase type 2 0.691 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361101 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361101&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135310662 386400491 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713668 Nc1nc2c(cccc2[nH]1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)NC[C@H]1CCNC1 InChI=1S/C19H20N10O4S2/c20-19-24-13-3-1-2-12(16(13)25-19)11-4-5-14(35(32,33)23-9-10-6-7-22-8-10)17(34(21,30)31)15(11)18-26-28-29-27-18/h1-5,10,22-23H,6-9H2,(H2,20,24)(H2,21,30,31)/b12-11+/t10-/m0/s1 ULQOOYRFAAKADH-IUZMTQGWSA-N 361102 (S)-4-(2-amino-1H- benzo[d]imidazol-4-yl)-N1- (pyrrolidin-3-ylmethyl)-3-(2H- tetrazol-5-yl)benzene-1,2- disulfonamide::US10221163, Example 259::US10544130, Example 259 Metallo-beta-lactamase type 2 0.836 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361102 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361102&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311424 386400492 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713671 Nc1nc2c(cccc2[nH]1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)NC1CCNCC1 InChI=1S/C19H22N10O4S2/c20-19-23-13-3-1-2-12(16(13)24-19)11-4-5-14(35(32,33)27-10-6-8-22-9-7-10)17(34(21,30)31)15(11)18-25-28-29-26-18/h1-5,10,22,27H,6-9H2,(H3,20,23,24)(H2,21,30,31)(H,25,26,28,29) YUBFCSFQTYJUHP-UHFFFAOYSA-N 361103 4-(2-amino-1H- benzo[d]imidazol-4-yl)-N1- (piperidin-4-yl)-3-(1H-tetrazol- 5-yl)benzene-1,2-disulfonamide::US10221163, Example 260::US10544130, Example 260 Metallo-beta-lactamase type 2 0.648 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361103 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361103&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135310788 386400493 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713674 Nc1nc2c(cccc2[nH]1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)NC[C@H]1CCCN1 InChI=1S/C19H20N10O4S2/c20-19-24-13-5-1-4-12(16(13)25-19)11-6-7-14(35(32,33)23-9-10-3-2-8-22-10)17(34(21,30)31)15(11)18-26-28-29-27-18/h1,4-7,10,22-23H,2-3,8-9H2,(H2,20,24)(H2,21,30,31)/b12-11+/t10-/m1/s1 IPKUSPMDIPJHQO-PJSNMCHCSA-N 361104 (R)-4-(2-amino-1H-benzo[d] imidazol-4-yl)-N1-(pyrrolidin-2- ylmethyl)-3-(2H-tetrazol-5-yl) benzene-1,2-disulfonamide::US10221163, Example 261::US10544130, Example 261 Metallo-beta-lactamase type 2 0.648 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361104 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361104&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311769 386400494 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713677 Nc1nc2c(cccc2[nH]1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)NC[C@@H]1CCCN1 InChI=1S/C19H20N10O4S2/c20-19-24-13-5-1-4-12(16(13)25-19)11-6-7-14(35(32,33)23-9-10-3-2-8-22-10)17(34(21,30)31)15(11)18-26-28-29-27-18/h1,4-7,10,22-23H,2-3,8-9H2,(H2,20,24)(H2,21,30,31)/b12-11+/t10-/m0/s1 IPKUSPMDIPJHQO-IUZMTQGWSA-N 361105 (S)-4-(2-amino-1H- benzo[d]imidazol-4-yl)-N1- (pyrrolidin-2-ylmethyl)-3-(2H- tetrazol-5-yl)benzene-1,2- disulfonamide::US10221163, Example 262::US10544130, Example 262 Metallo-beta-lactamase type 2 0.925 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361105 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361105&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135310755 386400495 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713680 Nc1nc2c(cccc2[nH]1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)NC[C@@H]1CCNC1 InChI=1S/C19H20N10O4S2/c20-19-24-13-3-1-2-12(16(13)25-19)11-4-5-14(35(32,33)23-9-10-6-7-22-8-10)17(34(21,30)31)15(11)18-26-28-29-27-18/h1-5,10,22-23H,6-9H2,(H2,20,24)(H2,21,30,31)/b12-11+/t10-/m1/s1 ULQOOYRFAAKADH-PJSNMCHCSA-N 361106 (R)-4-(2-amino-1H- benzo[d]imidazol-4-yl)-N1- (pyrrolidin-3-ylmethyl)-3-(2H- tetrazol-5-yl)benzene-1,2- disulfonamide::US10221163, Example 263::US10544130, Example 263 Metallo-beta-lactamase type 2 0.864 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361106 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361106&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135310716 386400496 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713683 CCC(CN)NS(=O)(=O)c1ccc(-c2cccc3[nH]c(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C18H20N10O4S2/c1-2-9(8-19)26-34(31,32)13-7-6-10(11-4-3-5-12-15(11)23-18(20)22-12)14(16(13)33(21,29)30)17-24-27-28-25-17/h3-7,9,26H,2,8,19H2,1H3,(H2,20,22)(H2,21,29,30)/b11-10+ HTZLMPQNWYVLLP-ZHACJKMWSA-N 361107 (S)-4-(2-amino-1H- benzo[d]imidazol-4-yl)-N1-(1- aminobutan-2-yl)-3-(2H- tetrazol-5-yl)benzene-1,2- disulfonamide::US10221163, Example 264 Metallo-beta-lactamase type 2 5.93 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361107 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361107&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135310859 386400497 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713686 CC[C@H](CN)NS(=O)(=O)c1ccc(-c2cccc3[nH]c(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C18H20N10O4S2/c1-2-9(8-19)26-34(31,32)13-7-6-10(11-4-3-5-12-15(11)23-18(20)22-12)14(16(13)33(21,29)30)17-24-27-28-25-17/h3-7,9,26H,2,8,19H2,1H3,(H2,20,22)(H2,21,29,30)/b11-10+/t9-/m1/s1 HTZLMPQNWYVLLP-HNLKAFMCSA-N 361108 (R)-4-(2-amino-1H-benzo[d] imidazol-4-yl)-N1-(1- aminobutan-2-yl)-3-(2H- tetrazol-5-yl)benzene-1,2- disulfonamide::US10221163, Example 265::US10544130, Example 265 Metallo-beta-lactamase type 2 0.292 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361108 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361108&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311156 386400498 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713689 C[C@H](CCN)NS(=O)(=O)c1ccc(-c2cccc3[nH]c(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C18H20N10O4S2/c1-9(7-8-19)26-34(31,32)13-6-5-10(11-3-2-4-12-15(11)23-18(20)22-12)14(16(13)33(21,29)30)17-24-27-28-25-17/h2-6,9,26H,7-8,19H2,1H3,(H2,20,22)(H2,21,29,30)/b11-10+/t9-/m1/s1 TZBMGYRGFPKTLT-HNLKAFMCSA-N 361109 (R)-4-(2-amino-1H- benzo[d]imidazol-4-yl)-N1-(4- aminobutan-2-yl)-3-(2H- tetrazol-5-yl)benzene-1,2- disulfonamide::US10221163, Example 266::US10544130, Example 266 Metallo-beta-lactamase type 2 0.477 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361109 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361109&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311136 386400499 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713692 C[C@@H](CCN)NS(=O)(=O)c1ccc(-c2cccc3[nH]c(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C18H20N10O4S2/c1-9(7-8-19)26-34(31,32)13-6-5-10(11-3-2-4-12-15(11)23-18(20)22-12)14(16(13)33(21,29)30)17-24-27-28-25-17/h2-6,9,26H,7-8,19H2,1H3,(H2,20,22)(H2,21,29,30)/b11-10+/t9-/m0/s1 TZBMGYRGFPKTLT-YHTNPHCKSA-N 361110 (S)-4-(2-amino-1H- benzo[d]imidazol-4-yl)-N1-(4- aminobutan-2-yl)-3-(2H- tetrazol-5-yl)benzene-1,2- disulfonamide::US10221163, Example 267::US10544130, Example 267 Metallo-beta-lactamase type 2 1.63 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361110 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361110&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311246 386400500 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713695 NCCN1CC[C@@H](C1)NS(=O)(=O)c1ccc(-c2cccc3[nH]c(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C20H23N11O4S2/c21-7-9-31-8-6-11(10-31)28-37(34,35)15-5-4-12(13-2-1-3-14-17(13)25-20(22)24-14)16(18(15)36(23,32)33)19-26-29-30-27-19/h1-5,11,28H,6-10,21H2,(H2,22,24)(H2,23,32,33)/b13-12+/t11-/m0/s1 WPTXVQKWHIQZFR-UMAGAQSHSA-N 361111 (S)-4-(2-amino-1H- benzo[d]imidazol-4-yl)-N1-(1- (2-aminoethyl)pyrrolidin-3-yl)- 3-(2H-tetrazol-5-yl)benzene-1,2- disulfonamide::US10221163, Example 268::US10544130, Example 268 Metallo-beta-lactamase type 2 1.10 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361111 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361111&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311221 386400501 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713698 NCC(=O)NC1CCCC(=C1)c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)N[C@@H]1CCNC1 361112 2-Amino-N-(4′-(N—((R)-pyrrolidin-3-yl)sulfamoyl)-3′-sulfamoyl-2′-(2H-tetrazol-5-yl)-3,4,5,6-tetrahydro-[1,1′-biphenyl]-3-yl)acetamide::US10221163, Example 269::US10544130, Example 269 Metallo-beta-lactamase type 2 4.03 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361112 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361112&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311091 386400502 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713701 NCC(=O)NC1CCC[C@H](C1)c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)N[C@@H]1CCNC1 361113 2-Amino-N-((3R)-3-(4-(N—((R)-pyrrolidin-3-yl)sulfamoyl)-3-sulfamoyl-2-(2H-tetrazol-5-yl)phenyl)cyclohexyl)acetamide::US10221163, Example 270::US10544130, Example 270 Metallo-beta-lactamase type 2 2.32 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361113 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361113&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124158419 386400503 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713704 NC(=O)c1nc2c(cccc2[nH]1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)N[C@@H]1CCNC1 InChI=1S/C19H18N10O5S2/c20-17(30)19-23-12-3-1-2-11(15(12)24-19)10-4-5-13(36(33,34)27-9-6-7-22-8-9)16(35(21,31)32)14(10)18-25-28-29-26-18/h1-5,9,22,27H,6-8H2,(H2,20,30)(H2,21,31,32)/b11-10+/t9-/m1/s1 AIVDFIBTNMFFIT-HNLKAFMCSA-N 361114 (R)-4-(4-(N-(pyrrolidin-3-yl)sulfamoyl)-3-sulfamoyl-2-(2H-tetrazol-5-yl) phenyl)-1H-benzo[d]imidazole-2-carboxamide::US10221163, Example 271::US10544130, Example 271 Metallo-beta-lactamase type 2 0.271 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361114 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361114&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135310763 386400504 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713707 C[C@H](N)c1nc2c(cccc2[nH]1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)N[C@@H]1CCNC1 InChI=1S/C20H22N10O4S2/c1-10(21)19-24-14-4-2-3-13(17(14)25-19)12-5-6-15(36(33,34)28-11-7-8-23-9-11)18(35(22,31)32)16(12)20-26-29-30-27-20/h2-6,10-11,23,28H,7-9,21H2,1H3,(H2,22,31,32)/b13-12+/t10-,11+/m0/s1 GSTBKORRVQRJRW-MRMLYHJQSA-N 361115 4-(2-((S)-1-aminoethyl)-1H-benzo[d]imidazol-4-yl)-N1-((R)-pyrrolidin-3-yl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 272::US10544130, Example 272 Metallo-beta-lactamase type 2 1.36 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361115 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361115&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135310730 386400505 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713710 C[C@@H](N)c1nc2c(cccc2[nH]1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)N[C@@H]1CCNC1 InChI=1S/C20H22N10O4S2/c1-10(21)19-24-14-4-2-3-13(17(14)25-19)12-5-6-15(36(33,34)28-11-7-8-23-9-11)18(35(22,31)32)16(12)20-26-29-30-27-20/h2-6,10-11,23,28H,7-9,21H2,1H3,(H2,22,31,32)/b13-12+/t10-,11-/m1/s1 GSTBKORRVQRJRW-AYHAQHTHSA-N 361116 4-(2-((R)-1-aminoethyl)-1H-benzo[d]imidazol-4-yl)-N1-((R)-pyrrolidin-3-yl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 273::US10544130, Example 273 Metallo-beta-lactamase type 2 1.41 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361116 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361116&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311536 386400506 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713713 NCc1nc2cc(ccc2[nH]1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)N[C@@H]1CCNC1 InChI=1S/C19H20N10O4S2/c20-8-16-23-13-3-1-10(7-14(13)24-16)12-2-4-15(35(32,33)27-11-5-6-22-9-11)18(34(21,30)31)17(12)19-25-28-29-26-19/h1-4,7,11,22,27H,5-6,8-9,20H2,(H2,21,30,31)/b12-10+/t11-/m1/s1 DCDMYVLTGDMZLG-KPMWUXBGSA-N 361117 (R)-4-(2-(aminomethyl)-1H-benzo[d]imidazol-5-yl)-N1-(pyrrolidin-3-yl)-3-(2H -tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 274::US10544130, Example 274 Metallo-beta-lactamase type 2 0.486 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361117 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361117&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311304 386400507 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713716 NCc1nc2cc(ccc2s1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)N[C@@H]1CCNC1 361118 (R)-4-(2-(aminomethyl)benzo[d]thiazol-5-yl)-N1-(pyrrolidin-3-yl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 275::US10544130, Example 275 Metallo-beta-lactamase type 2 0.171 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361118 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361118&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135310854 386400508 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713719 NCc1nc2c(cccc2s1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)N[C@@H]1CCNC1 361119 (R)-4-(2-(aminomethyl)benzo[d]thiazol-4-yl)-N1-(pyrrolidin-3-yl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 276::US10544130, Example 276 Metallo-beta-lactamase type 2 0.542 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361119 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361119&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135310855 386400509 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713722 Nc1cccc(n1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)N[C@@H]1CCNC1 361120 (R)-4-(6-aminopyridin-2-yl)-N1-(pyrrolidin-3-yl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 277::US10544130, Example 277 Metallo-beta-lactamase type 2 1.27 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361120 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361120&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311475 386400510 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713725 NCc1ncc([nH]1)-c1cccc(c1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)N[C@@H]1CCNC1 361121 (R)-3'-(2- (aminomethyl)-1H- imidazol-5-yl)-N4- (pyrrolidin-3-yl)-2-(2H- tetrazol-5-yl)-[1,1'- biphenyl]-3,4- disulfonamide::US10221163, Example 278::US10544130, Example 278 Metallo-beta-lactamase type 2 0.640 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361121 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361121&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135310819 386400511 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713728 NCCn1nc2cccc(-c3ccc(c(c3-c3nn[nH]n3)S(N)(=O)=O)S(=O)(=O)N[C@@H]3CCNC3)c2n1 361122 (R)-4-(2-(2-aminoethyl)- 2H-benzo[d][1,2,3] triazol-4-yl)-N1- (pyrrolidin-3-yl)-3-(2H- tetrazol-5-yl)benzene- 1,2-disulfonamide::US10221163, Example 279::US10544130, Example 279 Metallo-beta-lactamase type 2 3.03 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361122 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361122&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135310729 386400512 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713731 CNc1nc2c(cccc2[nH]1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)N[C@@H]1CCNC1 InChI=1S/C19H20N10O4S2/c1-21-19-23-13-4-2-3-12(16(13)24-19)11-5-6-14(35(32,33)27-10-7-8-22-9-10)17(34(20,30)31)15(11)18-25-28-29-26-18/h2-6,10,22,27H,7-9H2,1H3,(H,21,23)(H2,20,30,31)/b12-11+/t10-/m1/s1 YATNHHPIJDKXAT-PJSNMCHCSA-N 361123 (R)-4-(2-(methylamino)- 1H-benzo[d]imidazol-4- yl)-N1-(pyrrolidin-3-yl)- 3-(2H-tetrazol-5- yl)benzene-1,2- disulfonamide::US10221163, Example 280::US10544130, Example 280 Metallo-beta-lactamase type 2 0.610 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361123 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361123&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311688 386400513 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713734 Cn1nc2cccc(-c3ccc(c(c3-c3nn[nH]n3)S(N)(=O)=O)S(=O)(=O)N[C@@H]3CCNC3)c2n1 361124 (R)-4-(2-methyl-2H- benzo[d][1,2,3]triazol-4- yl)-N1-(pyrrolidin-3-yl)- 3-(2H-tetrazol-5- yl)benzene-1,2- disulfonamide::US10221163, Example 281::US10544130, Example 281 Metallo-beta-lactamase type 2 0.750 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361124 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361124&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311110 386400514 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713737 NS(=O)(=O)c1c(ccc(-c2cnc3cc[nH]c3c2)c1-c1nn[nH]n1)S(=O)(=O)N[C@@H]1CCNC1 InChI=1S/C18H17N9O4S2/c19-32(28,29)17-15(33(30,31)25-11-3-5-20-9-11)2-1-12(16(17)18-23-26-27-24-18)10-7-14-13(22-8-10)4-6-21-14/h1-2,4,6-8,11,20,25H,3,5,9H2,(H2,19,28,29)/b12-10-/t11-/m1/s1 MMHDAOZHHVINHD-JPQYHBGPSA-N 361125 (R)-N1-(pyrrolidin-3- yl)-4-(1H-pyrrolo[3,2- b]pyridin-6-yl)-3-(2H- tetrazol-5-yl)benzene- 1,2-disulfonamide::US10221163, Example 282::US10544130, Example 282 Metallo-beta-lactamase type 2 1.13 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361125 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361125&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269225 386400515 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713740 NCc1nc2c(cccc2[nH]1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)N[C@@H]1CCNC1 InChI=1S/C19H20N10O4S2/c20-8-15-23-13-3-1-2-12(17(13)24-15)11-4-5-14(35(32,33)27-10-6-7-22-9-10)18(34(21,30)31)16(11)19-25-28-29-26-19/h1-5,10,22,27H,6-9,20H2,(H2,21,30,31)/b12-11+/t10-/m1/s1 BDHPXSZMZFSUKR-PJSNMCHCSA-N 361126 (R)-4-(2-(aminomethyl)- 1H-benzo[d]imidazol-4- yl)-N1-(pyrrolidin-3-yl)- 3-(2H-tetrazol-5- yl)benzene-1,2- disulfonamide::US10221163, Example 283::US10544130, Example 283 Metallo-beta-lactamase type 2 1.20 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361126 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361126&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269226 386400516 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713743 Nc1ncc(s1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)N[C@@H]1CCNC1 361127 (R)-4-(2-aminothiazol-5- yl)-N1-pyrrolidin-3-yl)- 3-(2H-tetrazol-5- yl)benzene-1,2- disulfonamide::US10221163, Example 284::US10544130, Example 284 Metallo-beta-lactamase type 2 0.411 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361127 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361127&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 137537699 386400517 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713746 Cc1ccc(-c2ccc(c(c2-c2nn[nH]n2)S(N)(=O)=O)S(=O)(=O)N[C@@H]2CCNC2)c2nc(N)[nH]c12 InChI=1S/C19H20N10O4S2/c1-9-2-3-12(16-15(9)23-19(20)24-16)11-4-5-13(35(32,33)27-10-6-7-22-8-10)17(34(21,30)31)14(11)18-25-28-29-26-18/h2-5,10,22,27H,6-8H2,1H3,(H2,20,23)(H2,21,30,31)/b12-11+/t10-/m1/s1 XNKOFTAOJRCAMQ-PJSNMCHCSA-N 361128 (R)-4-(2-amino-7- methyl-1H- benzo[d]imidazol-4-yl)- N1-(pyrrolidin-3-yl)-3- (2H-tetrazol-5- yl)benzene-1,2- disulfonamide::US10221163, Example 285::US10544130, Example 285 Metallo-beta-lactamase type 2 0.318 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361128 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361128&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269227 386400518 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713749 Nc1ccc2cccc(-c3ccc(c(c3-c3nn[nH]n3)S(N)(=O)=O)S(=O)(=O)N[C@@H]3CCNC3)c2n1 361129 (R)-4-(2-aminoquinolin- 8-yl)-N1-(pyrrolidin-3- yl)-3-(2H-tetrazol-5- yl)benzene-1,2- disulfonamide::US10221163, Example 286::US10544130, Example 286 Metallo-beta-lactamase type 2 0.122 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361129 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361129&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269228 386400519 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713752 NS(=O)(=O)c1c(ccc(-c2cccc3ncccc23)c1-c1nn[nH]n1)S(=O)(=O)N[C@@H]1CCNC1 361130 (R)-N1-(pyrrolidin-3- yl)-4-(quinolin-5-yl)-3- (2H-tetrazol-5- yl)benzene-1,2- disulfonamide::US10221163, Example 287::US10544130, Example 287 Metallo-beta-lactamase type 2 0.617 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361130 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361130&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269229 386400520 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713755 Nc1cc(ccn1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)N[C@@H]1CCNC1 361131 (R)-4-(2-aminopyridin- 4-yl)-N1-(pyrrolidin-3- yl)-3-(2H-tetrazol-5- yl)benzene-1,2- disulfonamide::US10221163, Example 288::US10544130, Example 288 Metallo-beta-lactamase type 2 0.462 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361131 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361131&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269230 386400521 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713758 NCCn1nnc2c(cccc12)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)N[C@@H]1CCNC1 361132 (R)-4-(1-(2-aminoethyl)- 1H-benzo[d][1,2,3] triazol-4-yl)-N1- (pyrrolidin-3-yl)-3-(2H- tetrazol-5-yl)benzene- 1,2-disulfonamide yl)benzene-1,2- disulfonamide::US10221163, Example 289 Metallo-beta-lactamase type 2 1.22 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361132 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361132&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269231 386400522 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713761 NCc1csc(Nc2cccc(c2)-c2ccc(c(c2-c2nn[nH]n2)S(N)(=O)=O)S(=O)(=O)N[C@@H]2CCNC2)n1 361133 (R)-3'-((4- (aminomethyl)thiazol-2- yl)amino)-N4- (pyrrolidin-3-yl)-2-(2H- tetrazol-5-yl)-[1,1'- biphenyl]-3,4- disulfonamide::US10221163, Example 290::US10544130, Example 290 Metallo-beta-lactamase type 2 0.448 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361133 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361133&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269232 386400523 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713764 NS(=O)(=O)c1c(ccc(-c2cccn3ccnc23)c1-c1nn[nH]n1)S(=O)(=O)N[C@@H]1CCNC1 361134 (R)-4-(imidazo[1,2- a]pyridin-8-yl)-N1- (pyrrolidin-3-yl)-3-(2H- tetrazol-5-yl)benzene- 1,2-disulfonamide::US10221163, Example 291::US10544130, Example 291 Metallo-beta-lactamase type 2 0.169 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361134 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361134&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311135 386400524 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713767 NC(=O)c1nc2c(cccc2[nH]1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)N[C@H]1CCNC1 InChI=1S/C19H18N10O5S2/c20-17(30)19-23-12-3-1-2-11(15(12)24-19)10-4-5-13(36(33,34)27-9-6-7-22-8-9)16(35(21,31)32)14(10)18-25-28-29-26-18/h1-5,9,22,27H,6-8H2,(H2,20,30)(H2,21,31,32)/b11-10+/t9-/m0/s1 AIVDFIBTNMFFIT-YHTNPHCKSA-N 361135 (S)-4-(4-(N-(pyrrolidin-3-yl)sulfamoyl)-3-sulfamoyl-2-(2H-tetrazol-5-yl)phenyl)-1H-benzo[d]imidazole-2-carboxamide::US10221163, Example 292::US10544130, Example 292 Metallo-beta-lactamase type 2 0.672 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361135 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361135&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311276 386400525 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713770 Cn1nnc2c(cccc12)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)N[C@H]1CCNC1 361136 (S)-4-(1-methyl-1H- benzo[d][1,2,3]triazol- 4-yl)-N1-(pyrrolidin-3- yl)-3-(2H-tetrazol-5- yl)benzene-1,2- disulfonamide::US10221163, Example 293::US10544130, Example 293 Metallo-beta-lactamase type 2 1.30 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361136 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361136&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269233 386400526 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713773 Nc1nc(c[nH]1)-c1cccc(c1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)N[C@H]1CCNC1 361137 (S)-3'-(2-amino-1H- imidazol-4-yl)-N4- (pyrrolidin-3-yl)-2-(2H- tetrazol-5-yl)-[1,1'- biphenyl]-3,4- disulfonamide::US10221163, Example 294 Metallo-beta-lactamase type 2 1.72 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361137 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361137&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269234 386400527 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713776 CNc1nc2c(cccc2[nH]1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)N[C@H]1CCNC1 InChI=1S/C19H20N10O4S2/c1-21-19-23-13-4-2-3-12(16(13)24-19)11-5-6-14(35(32,33)27-10-7-8-22-9-10)17(34(20,30)31)15(11)18-25-28-29-26-18/h2-6,10,22,27H,7-9H2,1H3,(H,21,23)(H2,20,30,31)/b12-11+/t10-/m0/s1 YATNHHPIJDKXAT-IUZMTQGWSA-N 361138 (S)-4-(2-(methylamino)- 1H-benzo[d]imidazol-4- yl)-N1-(pyrrolidin-3- yl)-3-(2H-tetrazol-5- yl)benzene-1,2- disulfonamide::US10221163, Example 295::US10544130, Example 295 Metallo-beta-lactamase type 2 0.775 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361138 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361138&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269235 386400528 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713779 N[C@H](CO)CNS(=O)(=O)c1ccc(-c2cccc3[nH]cnc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C17H17N9O5S2/c18-9(7-27)6-22-33(30,31)13-5-4-10(11-2-1-3-12-15(11)21-8-20-12)14(16(13)32(19,28)29)17-23-25-26-24-17/h1-5,8-9,22,27H,6-7,18H2,(H2,19,28,29)/b11-10+/t9-/m0/s1 DJZFNJCFCYXAQT-YHTNPHCKSA-N 361139 (S)—N1-(2-amino-3-hydroxypropyl)-4-(1H-benzo[d]imidazol-4-yl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 296::US10544130, Example 296 Metallo-beta-lactamase type 2 0.198 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361139 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361139&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135310884 386400529 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713782 N[C@H](CO)CNS(=O)(=O)c1ccc(-c2ccc(N)nc2)c(-c2nn[nH]n2)c1S(N)(=O)=O 361140 (S)—N1-(2-amino-3-hydroxypropyl)-4-(6-aminopyridin-3-yl)-3-(2H -tetrazol-5-yl) benzene-1,2-disulfonamide::US10221163, Example 297::US10544130, Example 297 Metallo-beta-lactamase type 2 0.569 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361140 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361140&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124158510 386400530 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 712897 Nc1nc2cccc(-c3ccc(c(c3-c3nn[nH]n3)S(N)(=O)=O)S(N)(=O)=O)c2[nH]1 InChI=1S/C14H13N9O4S2/c15-14-18-8-3-1-2-7(11(8)19-14)6-4-5-9(28(16,24)25)12(29(17,26)27)10(6)13-20-22-23-21-13/h1-5H,(H3,15,18,19)(H2,16,24,25)(H2,17,26,27)(H,20,21,22,23) VVGDNPGVZIEQAP-UHFFFAOYSA-N 360338 4-(2-amino-3H-benzo[d]imidazol-4-yl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 1::US10544130, Example 1 Metallo-beta-lactamase type 2 0.581 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360338 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360338&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124159584 386399745 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 712900 Nc1ccc2cccc(-c3ccc(c(c3-c3nn[nH]n3)S(N)(=O)=O)S(N)(=O)=O)c2n1 InChI=1S/C16H14N8O4S2/c17-12-7-4-8-2-1-3-10(14(8)20-12)9-5-6-11(29(18,25)26)15(30(19,27)28)13(9)16-21-23-24-22-16/h1-7H,(H2,17,20)(H2,18,25,26)(H2,19,27,28)(H,21,22,23,24) VDGZDOXAAFBKEX-UHFFFAOYSA-N 360345 4-(2-aminoquinolin-8-yl)-3- (2H-tetrazol-5-yl)benzene- 1,2-disulfonamide::US10221163, Example 2::US10544130, Example 2 Metallo-beta-lactamase type 2 0.279 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360345 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360345&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311171 386399752 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 712903 NS(=O)(=O)c1ccc(-c2cccc3cn[nH]c23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C14H12N8O4S2/c15-27(23,24)10-5-4-8(9-3-1-2-7-6-17-18-12(7)9)11(13(10)28(16,25)26)14-19-21-22-20-14/h1-6H,(H,17,18)(H2,15,23,24)(H2,16,25,26)(H,19,20,21,22) LITRKXUVXQDMIS-UHFFFAOYSA-N 360363 4-(1H-indazol-7-yl)-3-(2H- tetrazol-5-yl)benzene-1,2- disulfonamide::US10221163, Example 3::US10221163, Example 7::US10544130, Example 3 Metallo-beta-lactamase type 2 0.233 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360363 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360363&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311274 386399767 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 712906 Nc1nc2c(cccc2o1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(N)(=O)=O InChI=1S/C14H12N8O5S2/c15-14-18-11-7(2-1-3-8(11)27-14)6-4-5-9(28(16,23)24)12(29(17,25)26)10(6)13-19-21-22-20-13/h1-5H,(H2,15,18)(H2,16,23,24)(H2,17,25,26)(H,19,20,21,22) XSWVMWMRFVXDMM-UHFFFAOYSA-N 360848 4-(2-aminobenzo[d]oxazol- 4-yl)-3-(2H-tetrazol-5- yl)benzene-1,2- disulfonamide::US10221163, Example 4::US10544130, Example 4 Metallo-beta-lactamase type 2 0.354 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360848 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360848&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311043 386400242 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 712909 Cn1c(N)nc2c(cccc12)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(N)(=O)=O InChI=1S/C15H15N9O4S2/c1-24-9-4-2-3-8(12(9)19-15(24)16)7-5-6-10(29(17,25)26)13(30(18,27)28)11(7)14-20-22-23-21-14/h2-6H,1H3,(H2,16,19)(H2,17,25,26)(H2,18,27,28)(H,20,21,22,23) DHHOUQGEQFJXDP-UHFFFAOYSA-N 360849 4-(2-amino-1-methyl-1H- benzo[d]imidazol-4-yl)-3- (2H-tetrazol-5-yl)benzene- 1,2-disulfonamide::US10221163, Example 5::US10544130, Example 5 Metallo-beta-lactamase type 2 0.346 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360849 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360849&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135310692 386400243 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 712912 Cc1ccc(-c2ccc(c(c2-c2nn[nH]n2)S(N)(=O)=O)S(N)(=O)=O)c2nc(N)sc12 InChI=1S/C15H14N8O4S3/c1-6-2-3-8(11-12(6)28-15(16)19-11)7-4-5-9(29(17,24)25)13(30(18,26)27)10(7)14-20-22-23-21-14/h2-5H,1H3,(H2,16,19)(H2,17,24,25)(H2,18,26,27)(H,20,21,22,23) CRWZLJNNDOWHSX-UHFFFAOYSA-N 360850 4-(2-amino-7- methylbenzo[d]thiazol-4-yl)- 3-(2H-tetrazol-5-yl)benzene- 1,2-disulfonamide::US10221163, Example 6::US10544130, Example 6 Metallo-beta-lactamase type 2 0.065 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360850 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360850&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311034 386400244 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 712915 NS(=O)(=O)c1ccc(-c2cccc3cn[nH]c23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C14H12N8O4S2/c15-27(23,24)10-5-4-8(9-3-1-2-7-6-17-18-12(7)9)11(13(10)28(16,25)26)14-19-21-22-20-14/h1-6H,(H,17,18)(H2,15,23,24)(H2,16,25,26)(H,19,20,21,22) LITRKXUVXQDMIS-UHFFFAOYSA-N 360363 4-(1H-indazol-7-yl)-3-(2H- tetrazol-5-yl)benzene-1,2- disulfonamide::US10221163, Example 3::US10221163, Example 7::US10544130, Example 3 Metallo-beta-lactamase type 2 0.214 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360363 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360363&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311274 386399767 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 712918 NS(=O)(=O)c1ccc(-c2cccc3[nH]c(nc23)C(O)=O)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C15H12N8O6S2/c16-30(26,27)9-5-4-6(10(12(9)31(17,28)29)13-20-22-23-21-13)7-2-1-3-8-11(7)19-14(18-8)15(24)25/h1-5H,(H,18,19)(H,24,25)(H2,16,26,27)(H2,17,28,29)(H,20,21,22,23) PHSIHADDWCLCLE-UHFFFAOYSA-N 360852 4-(3,4-disulfamoyl-2-(2H-tetrazol-5-yl)phenyl)-1H-benzo[d]imidazole-2-carboxylic acid::US10221163, Example 8::US10544130, Example 8 Metallo-beta-lactamase type 2 0.361 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360852 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360852&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124159700 386400245 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 712921 NCCNS(=O)(=O)c1ccc(-c2cccc3cn[nH]c23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C16H17N9O4S2/c17-6-7-20-31(28,29)12-5-4-10(11-3-1-2-9-8-19-21-14(9)11)13(15(12)30(18,26)27)16-22-24-25-23-16/h1-5,8,20H,6-7,17H2,(H,19,21)(H2,18,26,27)(H,22,23,24,25) CWJKRRQBAPFZIH-UHFFFAOYSA-N 360853 N1-(2-aminoethyl)-4-(1H-indazol-7-yl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 9::US10544130, Example 9 Metallo-beta-lactamase type 2 0.171 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360853 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360853&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124158388 386400246 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 712924 Cn1c(N)nc2c(cccc12)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)NCCN InChI=1S/C17H20N10O4S2/c1-27-11-4-2-3-10(14(11)22-17(27)19)9-5-6-12(33(30,31)21-8-7-18)15(32(20,28)29)13(9)16-23-25-26-24-16/h2-6,21H,7-8,18H2,1H3,(H2,19,22)(H2,20,28,29)(H,23,24,25,26) MIAXLWJVTIMZHF-UHFFFAOYSA-N 360854 4-(2-amino-1-methyl-1H- benzo[d]imidazol-4-yl)- N1-(2-aminoethyl)-3-(2H- tetrazol-5-yl)benzene-1,2- disulfonamide hydrochloride::US10221163, Example 10::US10544130, Example 10 Metallo-beta-lactamase type 2 0.235 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360854 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360854&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311847 386400247 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 712927 NCCNS(=O)(=O)c1ccc(-c2cccc3oc(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C16H17N9O5S2/c17-6-7-20-32(28,29)11-5-4-8(9-2-1-3-10-13(9)21-16(18)30-10)12(14(11)31(19,26)27)15-22-24-25-23-15/h1-5,20H,6-7,17H2,(H2,18,21)(H2,19,26,27)(H,22,23,24,25) CJZITJYNLXIFBE-UHFFFAOYSA-N 360855 4-(2-aminobenzo[d]oxazol- 4-yl)-N1-(2-aminoethyl)-3- (2H-tetrazol-5-yl)benzene- 1,2-disulfonamide::US10221163, Example 11 Metallo-beta-lactamase type 2 0.105 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360855 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360855&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311124 386400248 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 712930 NCCNS(=O)(=O)c1ccc(-c2cccc3[nH]c(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C16H18N10O4S2/c17-6-7-20-32(29,30)11-5-4-8(9-2-1-3-10-13(9)22-16(18)21-10)12(14(11)31(19,27)28)15-23-25-26-24-15/h1-5,20H,6-7,17H2,(H3,18,21,22)(H2,19,27,28)(H,23,24,25,26) GJZGXWPLIMVUDJ-UHFFFAOYSA-N 360856 4-(2-amino-1H- benzo[d]imidazol-4-yl)-N1- (2-aminoethyl)-3-(2H- tetrazol-5-yl)benzene-1,2- disulfonamide::US10221163, Example 12 Metallo-beta-lactamase type 2 0.316 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360856 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360856&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311296 386400249 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 712933 NCCNS(=O)(=O)c1ccc(-c2cccc3oc(nc23)C(O)=O)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C17H16N8O7S2/c18-6-7-20-34(30,31)11-5-4-8(12(14(11)33(19,28)29)15-22-24-25-23-15)9-2-1-3-10-13(9)21-16(32-10)17(26)27/h1-5,20H,6-7,18H2,(H,26,27)(H2,19,28,29)(H,22,23,24,25) JTQVEIOPHVMFAR-UHFFFAOYSA-N 360857 4-(4-(N-(2-aminoethyl)sulfamoyl)-3-sulfamoyl-2-(2H-tetrazol-5-yl)phenyl)benzo[d]oxazole-2-carboxylic acid::US10221163, Example 13::US10544130, Example 13 Metallo-beta-lactamase type 2 2.14 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360857 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360857&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124159659 386400250 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 712936 Nc1nc2c(cccc2s1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)NC1CCS(=O)(=O)CC1 InChI=1S/C19H20N8O6S4/c20-19-22-16-12(2-1-3-13(16)34-19)11-4-5-14(17(36(21,30)31)15(11)18-23-26-27-24-18)37(32,33)25-10-6-8-35(28,29)9-7-10/h1-5,10,25H,6-9H2,(H2,20,22)(H2,21,30,31)(H,23,24,26,27) NJNPJGQDAFDHTB-UHFFFAOYSA-N 360858 4-(2-amino-1,3- benzothiazol-4-yl)-N1- (1,1-dioxidotetrahydro-2H- thiopyran-4-yl)-3-(1H- tetrazol-5-yl)benzene-1,2- disulfonamide::US10221163, Example 14::US10544130, Example 14 Metallo-beta-lactamase type 2 0.173 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360858 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360858&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135310908 386400251 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 712939 Nc1nc2c(cccc2s1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)NCCN1CCNC(=O)C1 InChI=1S/C20H22N10O5S3/c21-20-25-17-12(2-1-3-13(17)36-20)11-4-5-14(18(37(22,32)33)16(11)19-26-28-29-27-19)38(34,35)24-7-9-30-8-6-23-15(31)10-30/h1-5,24H,6-10H2,(H2,21,25)(H,23,31)(H2,22,32,33)(H,26,27,28,29) IQVSMXLKXITUHA-UHFFFAOYSA-N 360859 4-(2-amino-1,3- benzothiazol-4-yl)-N1-[2- (3-oxopiperazin-1- yl)ethyl]-3-(1H-tetrazol-5- yl)benzene-1,2- disulfonamide::US10221163, Example 15::US10544130, Example 15 Metallo-beta-lactamase type 2 0.451 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360859 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360859&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311346 386400252 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727453 NC[C@@H](O)CS(=O)(=O)c1ccc(-c2ccc(N)nc2)c(-c2nn[nH]n2)c1S(N)(=O)=O 368177 (R)-6-((3-amino-2- hydroxypropyl)sulfonyl)- 3-(6-aminopyridin-3-yl)- 2-(2H-tetrazol-5-yl) benzenesulfonamide::US10227331, Example 364 Metallo-beta-lactamase type 2 0.486 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368177 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368177&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135149815 402365027 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727456 NC[C@H](O)CS(=O)(=O)c1ccc(-c2ccc(N)nc2)c(-c2nn[nH]n2)c1S(N)(=O)=O 368178 (S)-6-((3-amino-2- hydroxypropyl)sulfonyl)- 3-(6-aminopyridin-3-yl)- 2-(2H-tetrazol-5-yl) benzenesulfonamide::US10227331, Example 365 Metallo-beta-lactamase type 2 1.21 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368178 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368178&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135150069 402365028 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727459 NC[C@H](O)CS(=O)(=O)c1ccc(-c2cccc(c2)-c2c[nH]c(N)n2)c(-c2nn[nH]n2)c1S(N)(=O)=O 368179 (S)-3'-(2-amino-1H- imidazol-4-yl)-4-((3- amino-2- hydroxypropyl)sulfonyl)- 2-(2H-tetrazol-5-yl)-[1,1'- biphenyl]-3-sulfonamide::US10227331, Example 366 Metallo-beta-lactamase type 2 1.81 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368179 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368179&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 145713753 402365029 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727462 NC[C@@H](O)CS(=O)(=O)c1ccc(-c2cccnc2N)c(-c2nn[nH]n2)c1S(N)(=O)=O 368180 (R)-6-((3-amino-2- hydroxypropyl)sulfonyl)- 3-(2-aminopyridin-3-yl)- 2-(2H-tetrazol-5-yl) benzenesulfonamide::US10227331, Example 367 Metallo-beta-lactamase type 2 3.16 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368180 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368180&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135149572 402365030 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727465 NC[C@H](O)CS(=O)(=O)c1ccc(-c2cccnc2N)c(-c2nn[nH]n2)c1S(N)(=O)=O 368181 (S)-6-((3-amino-2- hydroxypropyl)sulfonyl)- 3-(2-aminopyridin-3-yl)- 2-(2H-tetrazol-5-yl) benzenesulfonamide::US10227331, Example 368 Metallo-beta-lactamase type 2 5.54 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368181 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368181&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135149944 402365031 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727468 NC[C@H](O)CS(=O)(=O)c1ccc(-c2cccc3[nH]c(CN)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C18H19N9O5S2/c19-6-9(28)8-33(29,30)13-5-4-10(11-2-1-3-12-16(11)23-14(7-20)22-12)15(17(13)34(21,31)32)18-24-26-27-25-18/h1-5,9,28H,6-8,19-20H2,(H2,21,31,32)/b11-10+/t9-/m0/s1 SGWRPWNGKPFUBY-YHTNPHCKSA-N 368182 (S)-6-((3-amino-2- hydroxypropyl)sulfonyl)- 3-(2-(aminomethyl)-1H- benzo[d]imidazol-4-yl)-2- (2H-tetrazol-5-yl) benzenesulfonamide::US10227331, Example 369 Metallo-beta-lactamase type 2 3.57 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368182 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368182&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135149872 402365032 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727471 NC[C@@H](O)CS(=O)(=O)c1ccc(-c2cccc3[nH]c(CN)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C18H19N9O5S2/c19-6-9(28)8-33(29,30)13-5-4-10(11-2-1-3-12-16(11)23-14(7-20)22-12)15(17(13)34(21,31)32)18-24-26-27-25-18/h1-5,9,28H,6-8,19-20H2,(H2,21,31,32)/b11-10+/t9-/m1/s1 SGWRPWNGKPFUBY-HNLKAFMCSA-N 368183 (R)-6-((3-amino-2- hydroxypropyl)sulfonyl)- 3-(2-(aminomethyl)-1H- benzo[d]imidazol-4-yl)-2- (2H-tetrazol-5-yl) benzenesulfonamide::US10227331, Example 370 Metallo-beta-lactamase type 2 1.25 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368183 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368183&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135149612 402365033 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727474 NC[C@@H](N)CS(=O)(=O)c1ccc(-c2ccc(N)nc2)c(-c2nn[nH]n2)c1S(N)(=O)=O 368184 (R)-3-(6-aminopyridin-3- yl)-6-((2,3- diaminopropyl)sulfonyl)- 2-(2H-tetrazol-5-yl) benzenesulfonamide::US10227331, Example 371 Metallo-beta-lactamase type 2 1.38 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368184 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368184&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135150071 402365034 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727477 NC[C@H](N)CS(=O)(=O)c1ccc(-c2ccc(N)nc2)c(-c2nn[nH]n2)c1S(N)(=O)=O 368185 (S)-3-(6-aminopyridin-3- yl)-6-((2,3- diaminopropyl)sulfonyl)- 2-(2H-tetrazol-5-yl) benzenesulfonamide::US10227331, Example 372 Metallo-beta-lactamase type 2 1.43 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368185 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368185&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135150122 402365035 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727480 Nc1nc2c(cccc2n1CCO)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)C1CNC1 InChI=1S/C19H21N9O5S2/c20-19-23-16-12(2-1-3-13(16)28(19)6-7-29)11-4-5-14(34(30,31)10-8-22-9-10)17(35(21,32)33)15(11)18-24-26-27-25-18/h1-5,10,22,29H,6-9H2,(H2,20,23)(H2,21,32,33)(H,24,25,26,27) QNUQSBOWDLHTPL-UHFFFAOYSA-N 368186 3-(2-Amino-1-(2-hydroxyethyl)-1H-benzo[d]imidazol-4-yl)-6-(azetidin-3-ylsulfonyl)-2-(2H-tetrazol-5-yl)benzenesulfonamide::US10227331, Example 373 Metallo-beta-lactamase type 2 0.409 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368186 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368186&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135150118 402365036 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 712942 CN(C)CC(F)(F)CNS(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nnn[nH]2)c1S(N)(=O)=O InChI=1S/C19H21F2N9O4S3/c1-30(2)9-19(20,21)8-24-37(33,34)13-7-6-10(11-4-3-5-12-15(11)25-18(22)35-12)14(16(13)36(23,31)32)17-26-28-29-27-17/h3-7,24H,8-9H2,1-2H3,(H2,22,25)(H2,23,31,32)(H,26,27,28,29) UXNGUTOGQXUODT-UHFFFAOYSA-N 360860 4-(2-amino-1,3- benzothiazol-4-yl)-N1-[3- (dimethylamino)-2,2- difluoropropyl]-3-(1H- tetrazol-5-yl)benzene-1,2- disulfonamide::US10221163, Example 16::US10544130, Example 16 Metallo-beta-lactamase type 2 0.442 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360860 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360860&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311248 386400253 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 712945 CN1CCOC(CNS(=O)(=O)c2ccc(-c3cccc4sc(N)nc34)c(-c3nnn[nH]3)c2S(N)(=O)=O)C1 360861 4-(2-amino-1,3- benzothiazol-4-yl)-N1-[(4- methylmorpholin-2- yl)methyl]-3-(1H-tetrazol- 5-yl)benzene-1,2- disulfonamide::US10221163, Example 17::US10544130, Example 17 Metallo-beta-lactamase type 2 0.430 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360861 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360861&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311518 386400254 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 712948 CN1CCCC(C1)NS(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nnn[nH]2)c1S(N)(=O)=O 360862 4-(2-amino-1,3- benzothiazol-4-yl)-N1-(1- methylpiperidin-3-yl)-3- (1H-tetrazol-5-yl)benzene- 1,2-disulfonamide::US10221163, Example 18::US10544130, Example 18 Metallo-beta-lactamase type 2 0.268 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360862 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360862&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311014 386400255 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 712951 Nc1nc2c(cccc2s1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)NCC1CCC(=O)N1 360863 4-(2-amino-1,3- benzothiazol-4-yl)-N1-[(5- oxopyrrolidin-2- yl)methyl]-3-(1H-tetrazol- 5-yl)benzene-1,2- disulfonamide::US10221163, Example 19::US10544130, Example 19 Metallo-beta-lactamase type 2 0.486 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360863 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360863&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135310834 386400256 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 712954 Cn1cnc(CNS(=O)(=O)c2ccc(-c3cccc4sc(N)nc34)c(-c3nnn[nH]3)c2S(N)(=O)=O)n1 InChI=1S/C18H17N11O4S3/c1-29-8-21-13(26-29)7-22-36(32,33)12-6-5-9(10-3-2-4-11-15(10)23-18(19)34-11)14(16(12)35(20,30)31)17-24-27-28-25-17/h2-6,8,22H,7H2,1H3,(H2,19,23)(H2,20,30,31)(H,24,25,27,28) KQHJVFYEQCPAAB-UHFFFAOYSA-N 360864 4-(2-amino-1,3- benzothiazol-4-yl)-N1-[(1- methyl-1H-1,2,4-triazol-3- yl)methyl]-3-(1H-tetrazol- 5-yl)benzene-1,2- disulfonamide::US10221163, Example 20::US10544130, Example 20 Metallo-beta-lactamase type 2 0.817 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360864 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360864&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311339 386400257 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 712957 Nc1nc2c(cccc2s1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)NCCN1CCC1 InChI=1S/C19H21N9O4S3/c20-19-23-16-12(3-1-4-13(16)33-19)11-5-6-14(35(31,32)22-7-10-28-8-2-9-28)17(34(21,29)30)15(11)18-24-26-27-25-18/h1,3-6,22H,2,7-10H2,(H2,20,23)(H2,21,29,30)(H,24,25,26,27) ZOIGAFIIRTZXOR-UHFFFAOYSA-N 360865 4-(2-amino-1,3- benzothiazol-4-yl)-N1-(2- azetidin-1-ylethyl)-3-(1H- tetrazol-5-yl)benzene-1,2- disulfonamide::US10221163, Example 21::US10544130, Example 21 Metallo-beta-lactamase type 2 0.383 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360865 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360865&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135310717 386400258 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 712960 CN(C)CCNS(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nnn[nH]2)c1S(N)(=O)=O InChI=1S/C18H21N9O4S3/c1-27(2)9-8-21-34(30,31)13-7-6-10(11-4-3-5-12-15(11)22-18(19)32-12)14(16(13)33(20,28)29)17-23-25-26-24-17/h3-7,21H,8-9H2,1-2H3,(H2,19,22)(H2,20,28,29)(H,23,24,25,26) BZSYHKGTTGQSDN-UHFFFAOYSA-N 360866 4-(2-amino-1,3- benzothiazol-4-yl)-N1-[2- (dimethylamino)ethyl]-3- (1H-tetrazol-5-yl)benzene- 1,2-disulfonamide::US10221163, Example 22::US10544130, Example 22 Metallo-beta-lactamase type 2 0.413 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360866 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360866&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135310721 386400259 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 712963 CNC(=O)CNS(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nnn[nH]2)c1S(N)(=O)=O InChI=1S/C17H17N9O5S3/c1-20-12(27)7-21-34(30,31)11-6-5-8(9-3-2-4-10-14(9)22-17(18)32-10)13(15(11)33(19,28)29)16-23-25-26-24-16/h2-6,21H,7H2,1H3,(H2,18,22)(H,20,27)(H2,19,28,29)(H,23,24,25,26) MWQOZPQHEVVWNU-UHFFFAOYSA-N 360867 N2-{[4-(2-amino-1,3- benzothiazol-4-yl)-2- sulfamoyl-3-(1H-tetrazol- 5-yl)phenyl]sulfonyl}-N- methylglycinamide::US10221163, Example 23::US10544130, Example 23 Metallo-beta-lactamase type 2 0.294 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360867 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360867&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311692 386400260 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 712966 COCCNS(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nnn[nH]2)c1S(N)(=O)=O InChI=1S/C17H18N8O5S3/c1-30-8-7-20-33(28,29)12-6-5-9(10-3-2-4-11-14(10)21-17(18)31-11)13(15(12)32(19,26)27)16-22-24-25-23-16/h2-6,20H,7-8H2,1H3,(H2,18,21)(H2,19,26,27)(H,22,23,24,25) LNXPRASRSVXUTN-UHFFFAOYSA-N 360868 4-(2-amino-1,3- benzothiazol-4-yl)-N1-(2- methoxyethyl)-3-(1H- tetrazol-5-yl)benzene-1,2- disulfonamide::US10221163, Example 24::US10544130, Example 24 Metallo-beta-lactamase type 2 0.235 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360868 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360868&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311150 386400261 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 712969 Nc1nc2c(cccc2s1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)N1CCC(CO)CC1 InChI=1S/C20H22N8O5S3/c21-20-23-17-13(2-1-3-14(17)34-20)12-4-5-15(36(32,33)28-8-6-11(10-29)7-9-28)18(35(22,30)31)16(12)19-24-26-27-25-19/h1-5,11,29H,6-10H2,(H2,21,23)(H2,22,30,31)(H,24,25,26,27) PZZILJUFSUVPJQ-UHFFFAOYSA-N 360869 3-(2-amino-1,3- benzothiazol-4-yl)-6-{[4- (hydroxymethyl)piperidin- 1-yl]sulfonyl}-2-(1H- tetrazol-5- yl)benzenesulfonamide::US10221163, Example 25::US10544130, Example 25 Metallo-beta-lactamase type 2 2.24 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360869 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360869&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311719 386400262 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 712972 CN(C)C1CCN(CC1)S(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nnn[nH]2)c1S(N)(=O)=O InChI=1S/C21H25N9O4S3/c1-29(2)12-8-10-30(11-9-12)37(33,34)16-7-6-13(14-4-3-5-15-18(14)24-21(22)35-15)17(19(16)36(23,31)32)20-25-27-28-26-20/h3-7,12H,8-11H2,1-2H3,(H2,22,24)(H2,23,31,32)(H,25,26,27,28) QDKKWLLPLUZTAW-UHFFFAOYSA-N 360870 3-(2-amino-1,3- benzothiazol-4-yl)-6-{[4- (dimethylamino)piperidin- 1-yl]sulfonyl}-2-(1H- tetrazol-5- yl)benzenesulfonamide::US10221163, Example 26::US10544130, Example 26 Metallo-beta-lactamase type 2 1.15 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360870 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360870&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311538 386400263 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 712975 CN1CCN(CC1)S(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nnn[nH]2)c1S(N)(=O)=O InChI=1S/C19H21N9O4S3/c1-27-7-9-28(10-8-27)35(31,32)14-6-5-11(12-3-2-4-13-16(12)22-19(20)33-13)15(17(14)34(21,29)30)18-23-25-26-24-18/h2-6H,7-10H2,1H3,(H2,20,22)(H2,21,29,30)(H,23,24,25,26) UTQRORGNZQVVQY-UHFFFAOYSA-N 360871 3-(2-amino-1,3- benzothiazol-4-yl)-6-[(4- methylpiperazin-1- yl)sulfonyl]-2-(1H- tetrazol-5- yl)benzenesulfonamide::US10221163, Example 27::US10544130, Example 27 Metallo-beta-lactamase type 2 1.59 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360871 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360871&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135310976 386400264 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 712978 Nc1nc2c(cccc2s1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)N1CCNC(=O)C1 InChI=1S/C18H17N9O5S3/c19-18-22-15-10(2-1-3-11(15)33-18)9-4-5-12(35(31,32)27-7-6-21-13(28)8-27)16(34(20,29)30)14(9)17-23-25-26-24-17/h1-5H,6-8H2,(H2,19,22)(H,21,28)(H2,20,29,30)(H,23,24,25,26) GLBQLNGOYWLSPB-UHFFFAOYSA-N 360872 3-(2-amino-1,3- benzothiazol-4-yl)-6-[(3- oxopiperazin-1- yl)sulfonyl]-2-(1H- tetrazol-5- yl)benzenesulfonamide::US10221163, Example 28::US10544130, Example 28 Metallo-beta-lactamase type 2 0.646 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360872 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360872&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311875 386400265 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 712981 Nc1nc2c(cccc2s1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)N1CCOCC1 InChI=1S/C18H18N8O5S3/c19-18-21-15-11(2-1-3-12(15)32-18)10-4-5-13(34(29,30)26-6-8-31-9-7-26)16(33(20,27)28)14(10)17-22-24-25-23-17/h1-5H,6-9H2,(H2,19,21)(H2,20,27,28)(H,22,23,24,25) ZVAPKOHBUPNLTN-UHFFFAOYSA-N 360873 3-(2-amino-1,3- benzothiazol-4-yl)-6- (morpholin-4-ylsulfonyl)- 2-(1H-tetrazol-5- yl)benzenesulfonamide::US10221163, Example 29::US10544130, Example 29 Metallo-beta-lactamase type 2 2.08 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360873 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360873&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311547 386400266 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 712984 Nc1nc2c(cccc2s1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)NCCC1CNC1 InChI=1S/C19H21N9O4S3/c20-19-24-16-12(2-1-3-13(16)33-19)11-4-5-14(35(31,32)23-7-6-10-8-22-9-10)17(34(21,29)30)15(11)18-25-27-28-26-18/h1-5,10,22-23H,6-9H2,(H2,20,24)(H2,21,29,30)(H,25,26,27,28) IZVFPCAFESKVCW-UHFFFAOYSA-N 360874 4-(2-amino-1,3- benzothiazol-4-yl)-N1-(2- azetidin-3-ylethyl)-3-(1H- tetrazol-5-yl)benzene-1,2- disulfonamide::US10221163, Example 30::US10544130, Example 30 Metallo-beta-lactamase type 2 0.369 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360874 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360874&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311463 386400267 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 712987 CNCCNS(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nnn[nH]2)c1S(N)(=O)=O InChI=1S/C17H19N9O4S3/c1-20-7-8-21-33(29,30)12-6-5-9(10-3-2-4-11-14(10)22-17(18)31-11)13(15(12)32(19,27)28)16-23-25-26-24-16/h2-6,20-21H,7-8H2,1H3,(H2,18,22)(H2,19,27,28)(H,23,24,25,26) OUKQBVXVFXQAKN-UHFFFAOYSA-N 360875 4-(2-amino-1,3- benzothiazol-4-yl)-N1-[2- (methylamino)ethyl]-3- (1H-tetrazol-5-yl)benzene- 1,2-disulfonamide::US10221163, Example 31::US10544130, Example 31 Metallo-beta-lactamase type 2 2.02 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360875 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360875&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311051 386400268 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 712990 Nc1nc2c(cccc2s1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)NC1CCNCC1 InChI=1S/C19H21N9O4S3/c20-19-23-16-12(2-1-3-13(16)33-19)11-4-5-14(35(31,32)26-10-6-8-22-9-7-10)17(34(21,29)30)15(11)18-24-27-28-25-18/h1-5,10,22,26H,6-9H2,(H2,20,23)(H2,21,29,30)(H,24,25,27,28) MQPNMUKUHJVESA-UHFFFAOYSA-N 360876 4-(2-amino-1,3- benzothiazol-4-yl)-N1- piperidin-4-yl-3-(1H- tetrazol-5-yl)benzene-1,2- disulfonamide::US10221163, Example 32::US10544130, Example 32 Metallo-beta-lactamase type 2 0.340 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360876 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360876&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311486 386400269 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 712993 Nc1nc2c(cccc2s1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)NCCN1CCCCC1=O InChI=1S/C21H23N9O5S3/c22-21-25-18-13(4-3-5-14(18)36-21)12-7-8-15(19(37(23,32)33)17(12)20-26-28-29-27-20)38(34,35)24-9-11-30-10-2-1-6-16(30)31/h3-5,7-8,24H,1-2,6,9-11H2,(H2,22,25)(H2,23,32,33)(H,26,27,28,29) DTEHDBCPEXVDDP-UHFFFAOYSA-N 360877 4-(2-amino-1,3- benzothiazol-4-yl)-N1-[2- (2-oxopiperidin-1- yl)ethyl]-3-(1H-tetrazol-5- yl)benzene-1,2- disulfonamide::US10221163, Example 33::US10544130, Example 33 Metallo-beta-lactamase type 2 0.275 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360877 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360877&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311383 386400270 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 712996 COc1ccnc(CNS(=O)(=O)c2ccc(-c3cccc4sc(N)nc34)c(-c3nnn[nH]3)c2S(N)(=O)=O)n1 InChI=1S/C20H18N10O5S3/c1-35-15-7-8-23-14(25-15)9-24-38(33,34)13-6-5-10(11-3-2-4-12-17(11)26-20(21)36-12)16(18(13)37(22,31)32)19-27-29-30-28-19/h2-8,24H,9H2,1H3,(H2,21,26)(H2,22,31,32)(H,27,28,29,30) OEDGFHOVDDKFPY-UHFFFAOYSA-N 360878 4-(2-amino-1,3- benzothiazol-4-yl)-N1-[(4- methoxypyrimidin-2- yl)methyl]-3-(1H-tetrazol- 5-yl)benzene-1,2- disulfonamide::US10221163, Example 34::US10544130, Example 34 Metallo-beta-lactamase type 2 0.429 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360878 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360878&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269188 386400271 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 712999 Nc1nc2c(cccc2s1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)NC1CCc2nccn2C1 360879 4-(2-amino-1,3- benzothiazol-4-yl)-N1- (5,6,7,8- tetrahydroimidazo[1,2- a]pyridin-6-yl)-3-(1H- tetrazol-5-yl)benzene-1,2- disulfonamide::US10221163, Example 35::US10544130, Example 35 Metallo-beta-lactamase type 2 0.349 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360879 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360879&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269189 386400272 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713785 NC[C@@H](O)CNS(=O)(=O)c1ccc(-c2cccc3[nH]c(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C17H18N10O5S2/c18-6-8(28)7-21-34(31,32)12-5-4-9(10-2-1-3-11-14(10)23-17(19)22-11)13(15(12)33(20,29)30)16-24-26-27-25-16/h1-5,8,21,28H,6-7,18H2,(H2,19,22)(H2,20,29,30)/b10-9+/t8-/m1/s1 MTZJHJHGFHSZPC-KGSKPCQNSA-N 361141 (R)-4-(2-amino-1H-benzo[d]imidazol-4-yl)-N1-(3-amino-2-hydroxypropyl)-3-(2H-tetrazol-5-yl)-benzene-1,2-disulfonamide::US10221163, Example 298::US10544130, Example 298 Metallo-beta-lactamase type 2 0.671 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361141 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361141&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135310845 386400531 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713788 NC[C@@H](O)CNS(=O)(=O)c1ccc(-c2cccc3[nH]c(CN)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C18H20N10O5S2/c19-6-9(29)8-22-35(32,33)13-5-4-10(11-2-1-3-12-16(11)24-14(7-20)23-12)15(17(13)34(21,30)31)18-25-27-28-26-18/h1-5,9,22,29H,6-8,19-20H2,(H2,21,30,31)/b11-10+/t9-/m1/s1 DNSKQBUHFYKBFQ-HNLKAFMCSA-N 361142 (R)—N1-(3-amino-2-hydroxypropyl)-4-(2-(aminomethyl)-1H-benzo[d]imidazol-4-yl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 299 Metallo-beta-lactamase type 2 2.65 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361142 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361142&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135310873 386400532 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713791 NC[C@@H](O)CNS(=O)(=O)c1ccc(-c2cccc3sc(CN)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O 361143 (R)—N1-(3-amino-2-hydroxypropyl)-4-(2-(aminomethyl)benzo[d]thiazol-4-yl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 300::US10544130, Example 300 Metallo-beta-lactamase type 2 0.318 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361143 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361143&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311483 386400533 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713794 NC[C@@H](O)CNS(=O)(=O)c1ccc(-c2cccc3[nH]cnc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C17H17N9O5S2/c18-6-9(27)7-22-33(30,31)13-5-4-10(11-2-1-3-12-15(11)21-8-20-12)14(16(13)32(19,28)29)17-23-25-26-24-17/h1-5,8-9,22,27H,6-7,18H2,(H2,19,28,29)/b11-10+/t9-/m1/s1 OEBNAEHNFGQODH-HNLKAFMCSA-N 361144 (R)-4-(1H- benzo[d]imidazol-4-yl)- N1-(3-amino-2- hydroxypropyl)-3-(2H- tetrazol-5-yl)-benzene-1,2- disulfonamide::US10221163, Example 301::US10544130, Example 301 Metallo-beta-lactamase type 2 0.129 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361144 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361144&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269236 386400534 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713797 Cn1c(N)nc2c(cccc12)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)NC[C@H](O)CN 361145 (R)-4-(2-amino-1-methyl- 1H-benzo[d]imidazol-4- yl)-N1-(3-amino-2- hydroxypropyl)-3-(2H- tetrazol-5-yl)benzene-1,2- disulfonamide::US10221163, Example 302::US10544130, Example 302 Metallo-beta-lactamase type 2 0.341 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361145 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361145&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269237 386400535 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713800 NC[C@@H](O)CNS(=O)(=O)c1ccc(-c2ccc(N)nc2)c(-c2nn[nH]n2)c1S(N)(=O)=O 361146 (R)-N1-(3-amino-2- hydroxypropyl)-4-(6- aminopyridin-3-yl)-3-(2H- tetrazol-5-yl)benzene-1,2- disulfonamide::US10221163, Example 303::US10544130, Example 303 Metallo-beta-lactamase type 2 0.536 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361146 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361146&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269238 386400536 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727483 Nc1c(NCCO)cccc1-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)C1CNC1 InChI=1S/C18H22N8O5S2/c19-16-12(2-1-3-13(16)22-6-7-27)11-4-5-14(32(28,29)10-8-21-9-10)17(33(20,30)31)15(11)18-23-25-26-24-18/h1-5,10,21-22,27H,6-9,19H2,(H2,20,30,31)(H,23,24,25,26) FRFMLHLVUDXQCD-UHFFFAOYSA-N 368187 2′-Amino-4-(azetidin-3-ylsulfonyl)-3′-((2-hydroxyethyl)amino)-2-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-3-sulfonamide::US10227331, Example 374 Metallo-beta-lactamase type 2 2.71 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368187 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368187&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124157393 402365037 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727486 NCCCNC(=O)c1cccc(c1N)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)CCN InChI=1S/C19H25N9O5S2/c20-7-2-9-24-19(29)13-4-1-3-12(16(13)22)11-5-6-14(34(30,31)10-8-21)17(35(23,32)33)15(11)18-25-27-28-26-18/h1,3-6H,2,7-10,20-22H2,(H,24,29)(H2,23,32,33)(H,25,26,27,28) PWNOXLLTMPTKIY-UHFFFAOYSA-N 368188 2-Amino-4′-((2-aminoethyl)sulfonyl)-N-(3-aminopropyl)-3′-sulfamoyl-2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-3-carboxamide::US10227331, Example 375 Metallo-beta-lactamase type 2 1.71 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368188 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368188&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124157287 402365038 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727489 NCCS(=O)(=O)c1ccc(-c2cccc(C(=O)N[C@H]3CCNC3)c2N)c(-c2nn[nH]n2)c1S(N)(=O)=O 368189 (S)-2-Amino-4′-((2-aminoethyl)sulfonyl)-N-(pyrrolidin-3-yl)-3′-sulfamoyl-2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-3-carboxamide::US10227331, Example 376 Metallo-beta-lactamase type 2 2.58 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368189 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368189&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135150253 402365039 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727492 NCCS(=O)(=O)c1ccc(-c2cccc(C(=O)N[C@@H]3CCNC3)c2N)c(-c2nn[nH]n2)c1S(N)(=O)=O 368190 (R)-2-amino-4'-((2- aminoethyl)sulfonyl)- N-(pyrrolidin-3-yl)- 3'-sulfamoyl-2'-(2H- tetrazol-5-yl)-[1,1'- biphenyl]-3- carboxamide::US10227331, Example 377 Metallo-beta-lactamase type 2 1.88 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368190 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368190&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135150211 402365040 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727495 NCCNC(=O)c1cccc(c1N)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)CCN InChI=1S/C18H23N9O5S2/c19-6-8-23-18(28)12-3-1-2-11(15(12)21)10-4-5-13(33(29,30)9-7-20)16(34(22,31)32)14(10)17-24-26-27-25-17/h1-5H,6-9,19-21H2,(H,23,28)(H2,22,31,32)(H,24,25,26,27) BQNHNRSYRIBTTI-UHFFFAOYSA-N 368191 2-amino-N-(2- aminoethyl)-4'-((2- aminoethyl)sulfonyl)- 3'-sulfamoyl-2'-(2H- tetrazol-5-yl)-[1,1'- biphenyl]-3- carboxamide::US10227331, Example 378 Metallo-beta-lactamase type 2 5.10 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368191 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368191&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135149703 402365041 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 727498 NC[C@@H](O)CS(=O)(=O)c1ccc(-c2cc(I)cc3[nH]c(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C17H16IN9O5S2/c18-7-3-10(14-11(4-7)22-17(20)23-14)9-1-2-12(33(29,30)6-8(28)5-19)15(34(21,31)32)13(9)16-24-26-27-25-16/h1-4,8,28H,5-6,19H2,(H2,20,22)(H2,21,31,32)/b10-9+/t8-/m1/s1 RTKRLHZRUKUNSA-KGSKPCQNSA-N 368192 (R)-6-((3-amino-2-hydroxypropyl)sulfonyl)-3-(2-amino-6-iodo-1H-benzo[d]imidazol-4-yl)-2-(2H-tetrazol-5-yl)benzenesulfonamide::US10227331, Example 379 Metallo-beta-lactamase type 2 0.170 US Patent 10.7270/Q2Z60RCD aid1798040 US10227331 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368192 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368192&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135149667 402365042 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713002 CN(C)C(=O)CNS(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nnn[nH]2)c1S(N)(=O)=O InChI=1S/C18H19N9O5S3/c1-27(2)13(28)8-21-35(31,32)12-7-6-9(10-4-3-5-11-15(10)22-18(19)33-11)14(16(12)34(20,29)30)17-23-25-26-24-17/h3-7,21H,8H2,1-2H3,(H2,19,22)(H2,20,29,30)(H,23,24,25,26) REQDHYOMMZXOKJ-UHFFFAOYSA-N 360880 N2-{[4-(2-amino-1,3- benzothiazol-4-yl)-2- sulfamoyl-3-(1H-tetrazol- 5-yl)phenyl]sulfonyl}- N,N-dimethylglycinamide::US10221163, Example 36::US10544130, Example 36 Metallo-beta-lactamase type 2 0.247 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360880&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135310645 386400273 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713005 Nc1nc2c(cccc2s1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)NCC1(CO)CC1 InChI=1S/C19H20N8O5S3/c20-18-23-15-11(2-1-3-12(15)33-18)10-4-5-13(35(31,32)22-8-19(9-28)6-7-19)16(34(21,29)30)14(10)17-24-26-27-25-17/h1-5,22,28H,6-9H2,(H2,20,23)(H2,21,29,30)(H,24,25,26,27) JKXPEBYUPDCQQP-UHFFFAOYSA-N 360881 4-(2-amino-1,3- benzothiazol-4-yl)-N1-{[1- (hydroxymethyl)cyclopropyl] methyl}-3-(1H-tetrazol- 5-yl)benzene-1,2- disulfonamide::US10221163, Example 37::US10544130, Example 37 Metallo-beta-lactamase type 2 0.287 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360881 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360881&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311488 386400274 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713008 CN1CC2(C1)CCN(C2)S(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nnn[nH]2)c1S(N)(=O)=O InChI=1S/C21H23N9O4S3/c1-29-9-21(10-29)7-8-30(11-21)37(33,34)15-6-5-12(13-3-2-4-14-17(13)24-20(22)35-14)16(18(15)36(23,31)32)19-25-27-28-26-19/h2-6H,7-11H2,1H3,(H2,22,24)(H2,23,31,32)(H,25,26,27,28) MWPLZFTURBIIPM-UHFFFAOYSA-N 360882 3-(2-amino-1,3- benzothiazol-4-yl)-6-[(2- methyl-2,6- diazaspiro[3.4]oct-6- yl)sulfonyl]-2-(1H- tetrazol-5- yl)benzenesulfonamide::US10221163, Example 38::US10544130, Example 38 Metallo-beta-lactamase type 2 1.43 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360882 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360882&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311496 386400275 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713011 CN(C)C1CN(C1)S(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nnn[nH]2)c1S(N)(=O)=O InChI=1S/C19H21N9O4S3/c1-27(2)10-8-28(9-10)35(31,32)14-7-6-11(12-4-3-5-13-16(12)22-19(20)33-13)15(17(14)34(21,29)30)18-23-25-26-24-18/h3-7,10H,8-9H2,1-2H3,(H2,20,22)(H2,21,29,30)(H,23,24,25,26) FSBJMTPSCUKYHG-UHFFFAOYSA-N 360883 3-(2-amino-1,3- benzothiazol-4-yl)-6-{[3- (dimethylamino)azetidin- 1-yl]sulfonyl}-2-(1H- tetrazol-5- yl)benzenesulfonamide::US10221163, Example 39::US10544130, Example 39 Metallo-beta-lactamase type 2 0.878 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360883 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360883&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311445 386400276 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713014 Nc1nc2c(cccc2s1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)N1CC2CC1CS2(=O)=O 360884 3-(2-amino-1,3- benzothiazol-4-yl)-6-[(2,2- dioxido-2-thia-5- azabicyclo[2.2.1]hept-5- yl)sulfonyl]-2-(1H- tetrazol-5- yl)benzenesulfonamide::US10221163, Example 40::US10544130, Example 40 Metallo-beta-lactamase type 2 1.86 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360884 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360884&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135310752 386400277 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713017 CN(C1CCS(=O)(=O)C1)S(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nnn[nH]2)c1S(N)(=O)=O 360885 4-(2-amino-1,3- benzothiazol-4-yl)-N1-(1,1- dioxidotetrahydrothiophen- 3-yl)-N~1~-methyl-3-(1H- tetrazol-5-yl)benzene-1,2- disulfonamide::US10221163, Example 41::US10544130, Example 41 Metallo-beta-lactamase type 2 0.810 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360885 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360885&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 137537637 386400278 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713020 Nc1nc2c(cccc2s1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)N1CC(F)(F)C1 InChI=1S/C17H14F2N8O4S3/c18-17(19)6-27(7-17)34(30,31)11-5-4-8(9-2-1-3-10-13(9)22-16(20)32-10)12(14(11)33(21,28)29)15-23-25-26-24-15/h1-5H,6-7H2,(H2,20,22)(H2,21,28,29)(H,23,24,25,26) QFYYYMBQAPXZRF-UHFFFAOYSA-N 360886 3-(2-amino-1,3- benzothiazol-4-yl)-6-[(3,3- difluoroazetidin-1- yl)sulfonyl]-2-(1H- tetrazol-5- yl)benzenesulfonamide::US10221163, Example 42::US10544130, Example 42 Metallo-beta-lactamase type 2 0.700 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360886 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360886&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135310984 386400279 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713023 Nc1nc2c(cccc2s1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)N1CCC(F)(F)C1 InChI=1S/C18H16F2N8O4S3/c19-18(20)6-7-28(8-18)35(31,32)12-5-4-9(10-2-1-3-11-14(10)23-17(21)33-11)13(15(12)34(22,29)30)16-24-26-27-25-16/h1-5H,6-8H2,(H2,21,23)(H2,22,29,30)(H,24,25,26,27) CJRRJWJKRXTHEF-UHFFFAOYSA-N 360887 3-(2-amino-1,3- benzothiazol-4-yl)-6-[(3,3- difluoropyrrolidin-1- yl)sulfonyl]-2-(1H- tetrazol-5- yl)benzenesulfonamide::US10221163, Example 43::US10544130, Example 43 Metallo-beta-lactamase type 2 1.23 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360887 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360887&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311090 386400280 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713026 Nc1nc2c(cccc2s1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)N1CCS(=O)CC1 InChI=1S/C18H18N8O5S4/c19-18-21-15-11(2-1-3-12(15)32-18)10-4-5-13(35(30,31)26-6-8-33(27)9-7-26)16(34(20,28)29)14(10)17-22-24-25-23-17/h1-5H,6-9H2,(H2,19,21)(H2,20,28,29)(H,22,23,24,25) HMLMVOVUUWOJIT-UHFFFAOYSA-N 360888 3-(2-amino-1,3- benzothiazol-4-yl)-6-[(1- oxidothiomorpholin-4- yl)sulfonyl]-2-(1H- tetrazol-5- yl)benzenesulfonamide::US10221163, Example 44::US10544130, Example 44 Metallo-beta-lactamase type 2 2.22 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360888 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360888&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311642 386400281 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713029 CS(=O)(=O)C1CCN(C1)S(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nnn[nH]2)c1S(N)(=O)=O 360889 3-(2-amino-1,3- benzothiazol-4-yl)-6-{[3- (methylsulfonyl)pyrrolidin- 1-yl]sulfonyl}-2-(1H- tetrazol-5- yl)benzenesulfonamide::US10221163, Example 45::US10544130, Example 45 Metallo-beta-lactamase type 2 1.65 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360889 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360889&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311815 386400282 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713032 Nc1nc2c(cccc2s1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)NCC1(F)CNC1 InChI=1S/C18H18FN9O4S3/c19-18(6-22-7-18)8-23-35(31,32)12-5-4-9(10-2-1-3-11-14(10)24-17(20)33-11)13(15(12)34(21,29)30)16-25-27-28-26-16/h1-5,22-23H,6-8H2,(H2,20,24)(H2,21,29,30)(H,25,26,27,28) FBOXLDIWBOPBGH-UHFFFAOYSA-N 360890 4-(2-amino-1,3- benzothiazol-4-yl)-N1-[(3- fluoroazetidin-3- yl)methyl]-3-(1H-tetrazol- 5-yl)benzene-1,2- disulfonamide::US10221163, Example 46::US10221163, Example 91::US10544130, Example 91 Metallo-beta-lactamase type 2 0.289 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360890 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360890&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311332 386400283 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713035 NCC(F)(F)CNS(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nnn[nH]2)c1S(N)(=O)=O InChI=1S/C17H17F2N9O4S3/c18-17(19,6-20)7-23-35(31,32)11-5-4-8(9-2-1-3-10-13(9)24-16(21)33-10)12(14(11)34(22,29)30)15-25-27-28-26-15/h1-5,23H,6-7,20H2,(H2,21,24)(H2,22,29,30)(H,25,26,27,28) GAFUGIBXFLEVLZ-UHFFFAOYSA-N 360891 4-(2-amino-1,3- benzothiazol-4-yl)-N1-(3- amino-2,2-difluoropropyl)- 3-(1H-tetrazol-5- yl)benzene-1,2- disulfonamide::US10221163, Example 47::US10544130, Example 47 Metallo-beta-lactamase type 2 0.484 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360891 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360891&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311735 386400284 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713038 Nc1nc2c(cccc2s1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)N1CC2(C1)CCNC2 InChI=1S/C20H21N9O4S3/c21-19-24-16-12(2-1-3-13(16)34-19)11-4-5-14(17(35(22,30)31)15(11)18-25-27-28-26-18)36(32,33)29-9-20(10-29)6-7-23-8-20/h1-5,23H,6-10H2,(H2,21,24)(H2,22,30,31)(H,25,26,27,28) MOHHMIRAZDGHTA-UHFFFAOYSA-N 360892 3-(2-amino-1,3- benzothiazol-4-yl)-6-(2,6- diazaspiro[3.4]oct-2- ylsulfonyl)-2-(1H-tetrazol- 5-yl)benzenesulfonamide::US10221163, Example 48::US10544130, Example 48 Metallo-beta-lactamase type 2 0.951 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360892 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360892&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311094 386400285 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713041 NC(CCNS(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nnn[nH]2)c1S(N)(=O)=O)C(F)(F)F 360893 4-(2-amino-1,3- benzothiazol-4-yl)-N1-(3- amino-4,4,4- trifluorobutyl)-3-(1H- tetrazol-5-yl)benzene-1,2- disulfonamide::US10221163, Example 49::US10544130, Example 49 Metallo-beta-lactamase type 2 0.413 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360893 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360893&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135310985 386400286 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713044 Nc1nc2c(cccc2s1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)N[C@H]1CO[C@@H]2[C@H](O)CO[C@@H]12 360894 2-({[4-(2-amino-1,3- benzothiazol-4-yl)-2- sulfamoyl-3-(1H-tetrazol- 5- yl)phenyl]sulfonyl}amino)- 1,4:3,6-dianhydro-2- deoxy-D-allitol::US10221163, Example 50::US10544130, Example 50 Metallo-beta-lactamase type 2 0.263 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360894 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360894&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135312032 386400287 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713047 CC(CN1CCOCC1)NS(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nnn[nH]2)c1S(N)(=O)=O 360895 4-(2-amino-1,3- benzothiazol-4-yl)-N1-(1- methyl-2-morpholin-4- ylethyl)-3-(1H-tetrazol-5- yl)benzene-1,2- disulfonamide::US10221163, Example 51::US10544130, Example 51 Metallo-beta-lactamase type 2 0.393 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360895 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360895&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135310680 386400288 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713050 CN(C)CCCN(C)S(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nnn[nH]2)c1S(N)(=O)=O InChI=1S/C20H25N9O4S3/c1-28(2)10-5-11-29(3)36(32,33)15-9-8-12(13-6-4-7-14-17(13)23-20(21)34-14)16(18(15)35(22,30)31)19-24-26-27-25-19/h4,6-9H,5,10-11H2,1-3H3,(H2,21,23)(H2,22,30,31)(H,24,25,26,27) AHMBFQAMCZCYCG-UHFFFAOYSA-N 360896 4-(2-amino-1,3- benzothiazol-4-yl)-N1-[3- (dimethylamino)propyl]- N~1~-methyl-3-(1H- tetrazol-5-yl)benzene-1,2- disulfonamide::US10221163, Example 52::US10544130, Example 52 Metallo-beta-lactamase type 2 5.94 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360896 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360896&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311218 386400289 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713053 CN1CCC(C1)NS(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nnn[nH]2)c1S(N)(=O)=O 360897 4-(2-amino-1,3- benzothiazol-4-yl)-N1-(1- methylpyrrolidin-3-yl)-3- (1H-tetrazol-5-yl)benzene- 1,2-disulfonamide::US10221163, Example 53::US10544130, Example 53 Metallo-beta-lactamase type 2 0.298 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360897 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360897&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135310925 386400290 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713056 CN(C1CCN(C)C1)S(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nnn[nH]2)c1S(N)(=O)=O 360898 4-(2-amino-1,3- benzothiazol-4-yl)-N1- methyl-N1-(1- methylpyrrolidin-3-yl)-3- (1H-tetrazol-5-yl)benzene- 1,2-disulfonamide::US10221163, Example 54::US10544130, Example 54 Metallo-beta-lactamase type 2 1.93 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360898 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360898&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311010 386400291 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713059 Nc1nc2c(cccc2s1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)N1CCC(N)(CO)C1 360899 3-(2-amino-1,3- benzothiazol-4-yl)-6-{[3- amino-3- (hydroxymethyl)pyrrolidin- 1-yl]sulfonyl}-2-(1H- tetrazol-5- yl)benzenesulfonamide::US10221163, Example 55::US10544130, Example 55 Metallo-beta-lactamase type 2 0.860 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360899 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360899&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135312002 386400292 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713803 NC[C@H](O)CNS(=O)(=O)c1ccc(-c2cccc3[nH]c(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C17H18N10O5S2/c18-6-8(28)7-21-34(31,32)12-5-4-9(10-2-1-3-11-14(10)23-17(19)22-11)13(15(12)33(20,29)30)16-24-26-27-25-16/h1-5,8,21,28H,6-7,18H2,(H2,19,22)(H2,20,29,30)/b10-9+/t8-/m0/s1 MTZJHJHGFHSZPC-VPOJCXOPSA-N 361147 (S)-4-(2-amino-1H-benzo[d]imidazol-4-yl)-N1-(3-amino-2-hydroxypropyl)-3-(2H-tetrazol-5-yl)-benzene-1,2-disulfonamide::US10221163, Example 304::US10544130, Example 304 Metallo-beta-lactamase type 2 0.617 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361147 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361147&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311923 386400537 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713806 NC[C@H](O)CNS(=O)(=O)c1ccc(-c2cccc3[nH]c(CN)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C18H20N10O5S2/c19-6-9(29)8-22-35(32,33)13-5-4-10(11-2-1-3-12-16(11)24-14(7-20)23-12)15(17(13)34(21,30)31)18-25-27-28-26-18/h1-5,9,22,29H,6-8,19-20H2,(H2,21,30,31)/b11-10+/t9-/m0/s1 DNSKQBUHFYKBFQ-YHTNPHCKSA-N 361148 (S)—N1-(3-amino-2-hydroxypropyl)-4-(2-(aminomethyl)-1H-benzo[d]imidazole-4-yl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 305::US10544130, Example 305 Metallo-beta-lactamase type 2 2.06 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361148 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361148&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311272 386400538 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713809 NC[C@H](O)CNS(=O)(=O)c1ccc(-c2cccc3sc(CN)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O 361149 (S)—N1-(3-amino-2-hydroxypropyl)-4-(2-(aminom ethyl) benzo[d]thiazol-4-yl)-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 306::US10544130, Example 306 Metallo-beta-lactamase type 2 0.293 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361149 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361149&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135310723 386400539 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713812 NC[C@H](O)CNS(=O)(=O)c1ccc(-c2cccc3[nH]cnc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C17H17N9O5S2/c18-6-9(27)7-22-33(30,31)13-5-4-10(11-2-1-3-12-15(11)21-8-20-12)14(16(13)32(19,28)29)17-23-25-26-24-17/h1-5,8-9,22,27H,6-7,18H2,(H2,19,28,29)/b11-10+/t9-/m0/s1 OEBNAEHNFGQODH-YHTNPHCKSA-N 361150 (S)-4-(1H- benzo[d]imidazol-4-yl)- N1-(3-amino-2- hydroxypropyl)-3-(2H- tetrazol-5-yl)-benzene- 1,2-disulfonamide::US10221163, Example 307::US10544130, Example 307 Metallo-beta-lactamase type 2 0.258 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361150 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361150&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269239 386400540 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713815 Cn1c(N)nc2c(cccc12)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)NC[C@@H](O)CN 361151 (S)-4-(2-amino-1-methyl- 1H-benzo[d]imidazol-4- yl)-N1-(3-amino-2- hydroxypropyl)-3-(2H- tetrazol-5-yl)benzene- 1,2-disulfonamide::US10221163, Example 308::US10544130, Example 308 Metallo-beta-lactamase type 2 0.403 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361151 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361151&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269240 386400541 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713818 NC[C@H](O)CNS(=O)(=O)c1ccc(-c2ccc(N)nc2)c(-c2nn[nH]n2)c1S(N)(=O)=O 361152 (S)-N1-(3-amino-2- hydroxypropyl)-4-(6- aminopyridin-3-yl)-3- (2H-tetrazol-5- yl)benzene-1,2- disulfonamide::US10221163, Example 309::US10544130, Example 309 Metallo-beta-lactamase type 2 0.501 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361152 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361152&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269241 386400542 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713821 Nc1nc2c(cccc2[nH]1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)NC[C@@H]1CNCCN1 InChI=1S/C19H21N11O4S2/c20-19-25-13-3-1-2-12(16(13)26-19)11-4-5-14(36(33,34)24-9-10-8-22-6-7-23-10)17(35(21,31)32)15(11)18-27-29-30-28-18/h1-5,10,22-24H,6-9H2,(H2,20,25)(H2,21,31,32)/b12-11+/t10-/m0/s1 AUAQCWDTNCWURJ-IUZMTQGWSA-N 361153 (S)-4-(2-amino-1H-benzo[d]imidazol-4-yl)-N1-(piperazin-2-ylmethyl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 310::US10544130, Example 310 Metallo-beta-lactamase type 2 0.667 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361153 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361153&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311308 386400543 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713824 NCc1nc2c(cccc2[nH]1)-c1ccc(c(c1-c1nc[nH]n1)S(N)(=O)=O)S(=O)(=O)NC[C@@H]1CNCCN1 InChI=1S/C21H24N10O4S2/c22-8-17-29-15-3-1-2-14(19(15)30-17)13-4-5-16(37(34,35)28-10-12-9-24-6-7-25-12)20(36(23,32)33)18(13)21-26-11-27-31-21/h1-5,11-12,24-25,28H,6-10,22H2,(H2,23,32,33)/b14-13+,21-18-/t12-/m0/s1 JDOKPQZSAWNSCS-LEDGJYNBSA-N 361154 (S)-4-(2-(aminomethyl)-1H-benzo[d]imidazol-4-yl)-N-(piperazin-2-ylmethyl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 311 Metallo-beta-lactamase type 2 1.27 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361154 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361154&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 137537587 386400544 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713827 Nc1ccc(cn1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)NC[C@@H]1CNCCN1 361155 (S)-4-(6- aminopyridin-3- yl)-N1-(piperazin- 2-ylmethyl)-3-(2H- tetrazol-5- yl)benzene-1,2- disulfonamide::US10221163, Example 312::US10544130, Example 312 Metallo-beta-lactamase type 2 0.586 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361155 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361155&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269242 386400545 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713830 Nc1ncccc1-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)NC[C@@H]1CNCCN1 361156 (S)-4-(2- aminopyridin-3- yl)-N1-(piperazin- 2-ylmethyl)-3-(2H- tetrazol-5- yl)benzene-1,2- disulfonamide::US10221163, Example 313::US10544130, Example 313 Metallo-beta-lactamase type 2 1.30 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361156 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361156&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269243 386400546 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713833 Nc1nc2c(cccc2[nH]1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)NC[C@H]1CNCCN1 InChI=1S/C19H21N11O4S2/c20-19-25-13-3-1-2-12(16(13)26-19)11-4-5-14(36(33,34)24-9-10-8-22-6-7-23-10)17(35(21,31)32)15(11)18-27-29-30-28-18/h1-5,10,22-24H,6-9H2,(H2,20,25)(H2,21,31,32)/b12-11+/t10-/m1/s1 AUAQCWDTNCWURJ-PJSNMCHCSA-N 361157 (R)-4-(2-amino-1H-benzo[d]imidazol-4-yl)-N1-(piperazin-2-ylmethyl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 314::US10544130, Example 314 Metallo-beta-lactamase type 2 0.485 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361157 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361157&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124158409 386400547 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713836 Nc1ccc(cn1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)NC[C@H]1CNCCN1 361158 (R)-4-(6- aminopyridin-3- yl)-N1-(piperazin- 2-ylmethyl)-3- (1H-tetrazol-5- yl)benzene-1,2- disulfonamide::US10221163, Example 315::US10544130, Example 315 Metallo-beta-lactamase type 2 0.459 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361158 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361158&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269244 386400548 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713839 Nc1ncccc1-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)NC[C@H]1CNCCN1 361159 (R)-4-(2- aminopyridin-3- yl)-N1-(piperazin- 2-ylmethyl)-3- (1H-tetrazol-5- yl)benzene-1,2- disulfonamide::US10221163, Example 316::US10544130, Example 316 Metallo-beta-lactamase type 2 2.33 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361159 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361159&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269245 386400549 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713842 C[C@H](CN)NS(=O)(=O)c1ccc(-c2ccnc(N)c2)c(-c2nn[nH]n2)c1S(N)(=O)=O 361160 (R)—N1-(1-aminopropan-2-yl)-4-(2-aminopyridin-4-yl)-3-(2H -tetrazol-5-yl) benzene-1,2-disulfonamide::US10221163, Example 317::US10544130, Example 317 Metallo-beta-lactamase type 2 0.495 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361160 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361160&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135310749 386400550 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713845 C[C@H](CN)NS(=O)(=O)c1ccc(-c2cccc(N)n2)c(-c2nn[nH]n2)c1S(N)(=O)=O 361161 (R)—N1-(1-aminopropan-2-yl)-4-(6-aminopyridin-2-yl)-3-(2H-tetrazol-5-yl) benzene-1,2-disulfonamide::US10221163, Example 318::US10544130, Example 318 Metallo-beta-lactamase type 2 0.704 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361161 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361161&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311448 386400551 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713848 N[C@H]1CNC[C@H]1NS(=O)(=O)c1ccc(-c2cccc3ccc(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O 361162 N1-((3R,4S)-4-aminopyrrolidin-3-yl)-4-(2-aminoquinolin-8-yl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 319::US10544130, Example 319 Metallo-beta-lactamase type 2 0.265 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361162 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361162&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 137537600 386400552 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713851 N[C@H]1CNC[C@H]1NS(=O)(=O)c1ccc(-c2cnc3cc[nH]c3c2)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C18H18N10O4S2/c19-11-7-21-8-14(11)26-34(31,32)15-2-1-10(9-5-13-12(23-6-9)3-4-22-13)16(17(15)33(20,29)30)18-24-27-28-25-18/h1-6,11,14,21,26H,7-8,19H2,(H2,20,29,30)/b10-9-/t11-,14+/m0/s1 AVDOWAXKOVDGSF-GEQRGXFDSA-N 361163 N1-((3R,4S)-4-aminopyrrolidin-3-yl)-4-(1H-pyrrolo[3,2-b]pyridin-6-yl-3-(2H -tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 320::US10544130, Example 320 Metallo-beta-lactamase type 2 1.21 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361163 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361163&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311118 386400553 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713854 N[C@H]1CNC[C@H]1NS(=O)(=O)c1ccc(-c2cnc(N)s2)c(-c2nn[nH]n2)c1S(N)(=O)=O 361164 N1-((3R,4S)-4-aminopyrrolidin-3-yl)-4-(2-aminothiazol-5-yl)-3-(2H -tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 321::US10544130, Example 321 Metallo-beta-lactamase type 2 1.25 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361164 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361164&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135310993 386400554 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713857 N[C@@H]1CNC[C@H]1NS(=O)(=O)c1ccc(-c2cccc3[nH]c(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C18H19N11O4S2/c19-10-6-22-7-12(10)27-35(32,33)13-5-4-8(9-2-1-3-11-15(9)24-18(20)23-11)14(16(13)34(21,30)31)17-25-28-29-26-17/h1-5,10,12,22,27H,6-7,19H2,(H2,20,23)(H2,21,30,31)/b9-8+/t10-,12-/m1/s1 LIRUKQKKERNVIK-VCXMCINHSA-N 361165 4-(2-Amino-1H-benzo[d]imidazol-4-yl)-N1-((3S,4R)-4-aminopyrrolidin-3-yl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 322::US10221163, Example 424::US10544130, Example 424 Metallo-beta-lactamase type 2 0.738 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361165 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361165&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269246 386400555 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713860 N[C@H](CO)c1nc2c(cccc2[nH]1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)N[C@H]1CNC[C@H]1N InChI=1S/C20H23N11O5S2/c21-11-6-24-7-14(11)29-38(35,36)15-5-4-9(16(18(15)37(23,33)34)20-27-30-31-28-20)10-2-1-3-13-17(10)26-19(25-13)12(22)8-32/h1-5,11-12,14,24,29,32H,6-8,21-22H2,(H2,23,33,34)/b10-9+/t11-,12-,14+/m1/s1 RMSQROZEJIGAKY-WMAAAFJKSA-N 361166 4-(2-((S)-1-amino-2-hydroxyethyl)-1H-benzo[d]imidazol-4-yl)-N1-((3S,4R)-4-aminopyrrolidin-3-yl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 323::US10544130, Example 323 Metallo-beta-lactamase type 2 3.39 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361166 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361166&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269247 386400556 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713062 CCC1(CCNC1)NS(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nnn[nH]2)c1S(N)(=O)=O 360900 4-(2-amino-1,3- benzothiazol-4-yl)-N1-(3- ethylpyrrolidin-3-yl)-3- (1H-tetrazol-5-yl)benzene- 1,2-disulfonamide::US10221163, Example 56::US10544130, Example 56 Metallo-beta-lactamase type 2 0.342 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360900 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360900&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311472 386400293 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713065 CC1(CCCNC1)NS(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nnn[nH]2)c1S(N)(=O)=O 360901 4-(2-amino-1,3- benzothiazol-4-yl)-N1-(3- methylpiperidin-3-yl)-3- (1H-tetrazol-5-yl)benzene- 1,2-disulfonamide::US10221163, Example 57::US10544130, Example 57 Metallo-beta-lactamase type 2 0.554 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360901 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360901&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311340 386400294 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713068 Nc1nc2c(cccc2s1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)N[C@@H]1CNC[C@@H]1F 360902 4-(2-amino-1,3- benzothiazol-4-yl)-N1- [(3R,4S)-4- fluoropyrrolidin-3-yl]-3- (1H-tetrazol-5-yl)benzene- 1,2-disulfonamide::US10221163, Example 58::US10544130, Example 58 Metallo-beta-lactamase type 2 0.759 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360902 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360902&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311849 386400295 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713071 Nc1nc2c(cccc2s1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)N[C@H]1CNC[C@@H]1F 360903 4-(2-amino-1,3- benzothiazol-4-yl)-N1- [(3S,4S)-4- fluoropyrrolidin-3-yl]-3- (1H-tetrazol-5-yl)benzene- 1,2-disulfonamide::US10221163, Example 59::US10544130, Example 59 Metallo-beta-lactamase type 2 0.558 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360903 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360903&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135310691 386400296 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713074 Nc1nc2c(cccc2s1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)N[C@H]1CCNC1 360904 4-(2-amino-1,3- benzothiazol-4-yl)-N1- [(3S)-pyrrolidin-3-yl]-3- (1H-tetrazol-5-yl)benzene- 1,2-disulfonamide::US10221163, Example 60::US10544130, Example 60 Metallo-beta-lactamase type 2 0.679 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360904 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360904&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311395 386400297 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713077 N[C@H]1CCN(C1)S(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nnn[nH]2)c1S(N)(=O)=O 360905 3-(2-amino-1,3- benzothiazol-4-yl)-6- {[(3S)-3-aminopyrrolidin- 1-yl]sulfonyl}-2-(1H- tetrazol-5- yl)benzenesulfonamide::US10221163, Example 61::US10544130, Example 61 Metallo-beta-lactamase type 2 1.47 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360905 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360905&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311513 386400298 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713080 N[C@@H]1CCN(C1)S(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nnn[nH]2)c1S(N)(=O)=O 360906 3-(2-amino-1,3- benzothiazol-4-yl)-6- {[(3R)-3-aminopyrrolidin- 1-yl]sulfonyl}-2-(1H- tetrazol-5- yl)benzenesulfonamide::US10221163, Example 62::US10544130, Example 62 Metallo-beta-lactamase type 2 1.28 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360906 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360906&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311128 386400299 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713083 Nc1nc2c(cccc2s1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)N[C@@H]1CCNC1 360907 4-(2-amino-1,3- benzothiazol-4-yl)-N1- [(3R)-pyrrolidin-3-yl]-3- (1H-tetrazol-5-yl)benzene- 1,2-disulfonamide::US10221163, Example 63::US10544130, Example 63 Metallo-beta-lactamase type 2 0.307 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360907 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360907&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135310825 386400300 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713086 CN(C1CCCNC1)S(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nnn[nH]2)c1S(N)(=O)=O 360908 4-(2-amino-1,3- benzothiazol-4-yl)-N1- methyl-N1-piperidin-3-yl- 3-(1H-tetrazol-5- yl)benzene-1,2- disulfonamide::US10221163, Example 64::US10544130, Example 64 Metallo-beta-lactamase type 2 2.16 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360908 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360908&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311052 386400301 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713089 CN([C@H]1CCNC1)S(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nnn[nH]2)c1S(N)(=O)=O 360909 4-(2-amino-1,3- benzothiazol-4-yl)-N1- methyl-N1-[(3S)- pyrrolidin-3-yl]-3-(1H- tetrazol-5-yl)benzene-1,2- disulfonamide::US10221163, Example 65::US10544130, Example 65 Metallo-beta-lactamase type 2 0.703 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360909 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360909&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311008 386400302 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713092 N[C@H]1CCCN(C1)S(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nnn[nH]2)c1S(N)(=O)=O 360910 3-(2-amino-1,3- benzothiazol-4-yl)-6- {[(3S)-3-aminopiperidin-1- yl]sulfonyl}-2-(1H- tetrazol-5- yl)benzenesulfonamide::US10221163, Example 66::US10544130, Example 66 Metallo-beta-lactamase type 2 2.26 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360910 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360910&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311948 386400303 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713095 Nc1nc2c(cccc2s1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)N[C@H]1CCCNC1 360911 4-(2-amino-1,3- benzothiazol-4-yl)-N1- [(3S)-piperidin-3-yl]-3- (1H-tetrazol-5-yl)benzene- 1,2-disulfonamide::US10221163, Example 67::US10544130, Example 67 Metallo-beta-lactamase type 2 0.488 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360911 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360911&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311974 386400304 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713098 COc1ccc(CN(Cc2ccc(OC)cc2)S(=O)(=O)c2c(ccc(I)c2-c2nnn(Cc3ccc(OC)cc3)n2)S(=O)(=O)N[C@@H]2CCN(C2)C(=O)OC(C)(C)C)cc1 InChI=1S/C40H46IN7O9S2/c1-40(2,3)57-39(49)46-22-21-30(26-46)44-58(50,51)35-20-19-34(41)36(38-42-45-48(43-38)25-29-11-17-33(56-6)18-12-29)37(35)59(52,53)47(23-27-7-13-31(54-4)14-8-27)24-28-9-15-32(55-5)16-10-28/h7-20,30,44H,21-26H2,1-6H3/t30-/m1/s1 URIMKCJWSVIKRZ-SSEXGKCCSA-N 360912 (R)-tert-butyl 3-(2-(N,N-bis(4- methoxybenzyl)sulfamoyl)-4- iodo-3-(2-(4-methoxybenzyl)- 2H-tetrazol-5- yl)phenylsulfonamido)pyrrolidine- 1-carboxylate::US10221163, Example 68::US10544130, Example 72 Metallo-beta-lactamase type 2 1.97 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360912 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360912&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124158354 386400305 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713101 Nc1nc2c(cccc2s1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)N[C@@H]1CCCNC1 360913 4-(2-amino-1,3- benzothiazol-4-yl)-N1- [(3R)-piperidin-3-yl]-3- (1H-tetrazol-5-yl)benzene- 1,2-disulfonamide::US10221163, Example 69::US10544130, Example 69 Metallo-beta-lactamase type 2 0.184 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360913 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360913&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135310890 386400306 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713104 NC[C@@H]1CCN(C1)S(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nnn[nH]2)c1S(N)(=O)=O 360914 3-(2-amino-1,3- benzothiazol-4-yl)-6- {[(3S)-3- (aminomethyl)pyrrolidin- 1-yl]sulfonyl}-2-(1H- tetrazol-5- yl)benzenesulfonamide::US10221163, Example 70::US10221163, Example 94::US10544130, Example 94 Metallo-beta-lactamase type 2 2.31 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360914 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360914&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311199 386400307 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713107 N[C@H]1C[C@@H](C1)NS(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nnn[nH]2)c1S(N)(=O)=O 360915 4-(2-amino-1,3- benzothiazol-4-yl)-N1- (trans-3-aminocyclobutyl)- 3-(1H-tetrazol-5- yl)benzene-1,2- disulfonamide::US10221163, Example 71::US10544130, Example 98 Metallo-beta-lactamase type 2 0.355 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360915 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360915&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311334 386400308 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713110 COc1ccc(CN(Cc2ccc(OC)cc2)S(=O)(=O)c2c(ccc(I)c2-c2nnn(Cc3ccc(OC)cc3)n2)S(=O)(=O)N[C@H]2CCN(C2)C(=O)OC(C)(C)C)cc1 InChI=1S/C40H46IN7O9S2/c1-40(2,3)57-39(49)46-22-21-30(26-46)44-58(50,51)35-20-19-34(41)36(38-42-45-48(43-38)25-29-11-17-33(56-6)18-12-29)37(35)59(52,53)47(23-27-7-13-31(54-4)14-8-27)24-28-9-15-32(55-5)16-10-28/h7-20,30,44H,21-26H2,1-6H3/t30-/m0/s1 URIMKCJWSVIKRZ-PMERELPUSA-N 360916 (S)-tert-butyl 3-(2-(N,N-bis(4- methoxybenzyl)sulfamoyl)-4- iodo-3-(2-(4-methoxybenzyl)- 2H-tetrazol-5- yl)phenylsulfonamido)pyrrolidine- 1-carboxylate::US10221163, Example 72 Metallo-beta-lactamase type 2 0.270 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360916 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360916&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124158503 386400309 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713113 COc1ccc(CN(Cc2ccc(OC)cc2)S(=O)(=O)c2c(ccc(I)c2-c2nnn(Cc3ccc(OC)cc3)n2)S(=O)(=O)NC[C@@H](CO)NC(=O)OC(C)(C)C)cc1 InChI=1S/C39H46IN7O10S2/c1-39(2,3)57-38(49)42-29(25-48)21-41-58(50,51)34-20-19-33(40)35(37-43-45-47(44-37)24-28-11-17-32(56-6)18-12-28)36(34)59(52,53)46(22-26-7-13-30(54-4)14-8-26)23-27-9-15-31(55-5)16-10-27/h7-20,29,41,48H,21-25H2,1-6H3,(H,42,49)/t29-/m0/s1 RZOMAMNKJPYXFW-LJAQVGFWSA-N 360917 (S)-tert-butyl (1-(2-(N,N-bis(4- methoxybenzyl)sulfamoyl)-4- iodo-3-(2-(4-methoxybenzyl)- 2H-tetrazol-5- yl)phenylsulfonamido)-3- hydroxypropan-2-yl)carbamate::US10221163, Example 73::US10544130, Example 73 Metallo-beta-lactamase type 2 0.160 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360917 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360917&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269190 386400310 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713116 COc1ccc(CN(Cc2ccc(OC)cc2)S(=O)(=O)c2c(ccc(I)c2-c2nnn(Cc3ccc(OC)cc3)n2)S(=O)(=O)NC[C@H](O)CNC(=O)OC(C)(C)C)cc1 InChI=1S/C39H46IN7O10S2/c1-39(2,3)57-38(49)41-21-29(48)22-42-58(50,51)34-20-19-33(40)35(37-43-45-47(44-37)25-28-11-17-32(56-6)18-12-28)36(34)59(52,53)46(23-26-7-13-30(54-4)14-8-26)24-27-9-15-31(55-5)16-10-27/h7-20,29,42,48H,21-25H2,1-6H3,(H,41,49)/t29-/m1/s1 SYSQZTFYEUUIMG-GDLZYMKVSA-N 360918 (R)-tert-butyl (3-(2-(N,N-bis(4- methoxybenzyl)sulfamoyl)-4- iodo-3-(2-(4-methoxybenzyl)- 2H-tetrazol-5- yl)phenylsulfonamido)-2- hydroxypropyl)carbamate::US10221163, Example 74::US10544130, Example 74 Metallo-beta-lactamase type 2 0.840 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360918 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360918&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269191 386400311 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713119 COc1ccc(CN(Cc2ccc(OC)cc2)S(=O)(=O)c2c(ccc(I)c2-c2nnn(Cc3ccc(OC)cc3)n2)S(=O)(=O)NC[C@@H](O)CNC(=O)OC(C)(C)C)cc1 InChI=1S/C39H46IN7O10S2/c1-39(2,3)57-38(49)41-21-29(48)22-42-58(50,51)34-20-19-33(40)35(37-43-45-47(44-37)25-28-11-17-32(56-6)18-12-28)36(34)59(52,53)46(23-26-7-13-30(54-4)14-8-26)24-27-9-15-31(55-5)16-10-27/h7-20,29,42,48H,21-25H2,1-6H3,(H,41,49)/t29-/m0/s1 SYSQZTFYEUUIMG-LJAQVGFWSA-N 360919 (S)-tert-butyl (3-(2-(N,N-bis(4- methoxybenzyl)sulfamoyl)-4- iodo-3-(2-(4-methoxybenzyl)- 2H-tetrazol-5- yl)phenylsulfonamido)-2- hydroxypropyl)carbamate::US10221163, Example 75::US10544130, Example 75 Metallo-beta-lactamase type 2 0.158 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360919 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360919&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269192 386400312 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713122 COc1ccc(CN(Cc2ccc(OC)cc2)S(=O)(=O)c2c(ccc(I)c2-c2nnn(Cc3ccc(OC)cc3)n2)S(=O)(=O)NC[C@@H]2CN(CCN2C(=O)OC(C)(C)C)C(=O)OC(C)(C)C)cc1 InChI=1S/C46H57IN8O11S2/c1-45(2,3)65-43(56)52-24-25-54(44(57)66-46(4,5)6)34(30-52)26-48-67(58,59)39-23-22-38(47)40(42-49-51-55(50-42)29-33-14-20-37(64-9)21-15-33)41(39)68(60,61)53(27-31-10-16-35(62-7)17-11-31)28-32-12-18-36(63-8)19-13-32/h10-23,34,48H,24-30H2,1-9H3/t34-/m1/s1 CQVYWECRQQVMBR-UUWRZZSWSA-N 360920 (S)-di-tert-butyl 2-((2-(N,N-bis(4- methoxybenzyl)sulfamoyl)-4- iodo-3-(2-(4-methoxybenzyl)- 2H-tetrazol-5- yl)phenylsulfonamido)methyl) piperazine-1,4-dicarboxylate::US10221163, Example 76::US10544130, Example 76 Metallo-beta-lactamase type 2 0.195 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360920 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360920&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135310667 386400313 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713863 N[C@@H]1CNC[C@@H]1NS(=O)(=O)c1ccc(-c2cccc3ccc(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O 361167 N1-((3S,4R)-4- aminopyrrolidin-3-yl)-4- (2-aminoquinolin-8-yl)- 3-(1H-tetrazol-5- yl)benzene-1,2- disulfonamide::US10221163, Example 324::US10544130, Example 324 Metallo-beta-lactamase type 2 0.213 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361167 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361167&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269248 386400557 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713866 N[C@@H]1CNC[C@@H]1NS(=O)(=O)c1ccc(-c2cnc(N)s2)c(-c2nn[nH]n2)c1S(N)(=O)=O 361168 N1-((3S,4R)-4- aminopyrrolidin-3-yl)-4- (2-aminothiazol-5-yl)-3- (2H-tetrazol-5- yl)benzene-1,2- disulfonamide::US10221163, Example 325::US10544130, Example 325 Metallo-beta-lactamase type 2 1.22 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361168 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361168&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311358 386400558 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713869 N[C@@H]1CNC[C@@H]1NS(=O)(=O)c1ccc(-c2cnc3cc[nH]c3c2)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C18H18N10O4S2/c19-11-7-21-8-14(11)26-34(31,32)15-2-1-10(9-5-13-12(23-6-9)3-4-22-13)16(17(15)33(20,29)30)18-24-27-28-25-18/h1-6,11,14,21,26H,7-8,19H2,(H2,20,29,30)/b10-9-/t11-,14+/m1/s1 AVDOWAXKOVDGSF-VTSTVKRSSA-N 361169 N1-((3S,4R)-4- aminopyrrolidin-3-yl)-4- (1H-pyrrolo[3,2- b]pyridin-6-yl)-3-(2H- tetrazol-5-yl)benzene- 1,2-disulfonamide::US10221163, Example 326::US10544130, Example 326 Metallo-beta-lactamase type 2 0.650 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361169 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361169&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269249 386400559 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713872 N[C@@H]1CNC[C@@H]1NS(=O)(=O)c1ccc(-c2cccc(c2)-c2c[nH]c(N)n2)c(-c2nn[nH]n2)c1S(N)(=O)=O 361170 3'-(2-amino-1H-imidazol- 4-yl)-N4-((3S,4R)-4- aminopyrrolidin-3-yl)-2- (2H-tetrazol-5-yl)-[1,1'- biphenyl]-3,4- disulfonamide::US10221163, Example 327::US10544130, Example 327 Metallo-beta-lactamase type 2 1.41 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361170 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361170&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269250 386400560 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713875 N[C@@H]1CNC[C@@H]1NS(=O)(=O)c1ccc(-c2cccn3ccnc23)c(-c2nn[nH]n2)c1S(N)(=O)=O 361171 N1-((3S,4R)-4- aminopyrrolidin-3-yl)-4- (imidazo[1,2-a]pyridin-8- yl)-3-(2H-tetrazol-5- yl)benzene-1,2- disulfonamide::US10221163, Example 328::US10544130, Example 328 Metallo-beta-lactamase type 2 0.340 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361171 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361171&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311487 386400561 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713878 Cc1ccc(-c2ccc(c(c2-c2nn[nH]n2)S(N)(=O)=O)S(=O)(=O)NCCN)c2nc(N)[nH]c12 InChI=1S/C17H20N10O4S2/c1-8-2-3-10(14-13(8)22-17(19)23-14)9-4-5-11(33(30,31)21-7-6-18)15(32(20,28)29)12(9)16-24-26-27-25-16/h2-5,21H,6-7,18H2,1H3,(H3,19,22,23)(H2,20,28,29)(H,24,25,26,27) RQPNOZBYGYYABS-UHFFFAOYSA-N 361172 4-(2-Amino-7-methyl-1H-benzo[d]imidazol-4-yl)-N1-(2-aminoethyl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 329::US10544130, Example 329 Metallo-beta-lactamase type 2 0.128 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361172 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361172&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269251 386400562 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713881 NCCNS(=O)(=O)c1ccc(-c2cccc3[nH]c(nc23)[C@H](N)CO)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C18H20N10O5S2/c19-6-7-22-35(32,33)13-5-4-9(14(16(13)34(21,30)31)18-25-27-28-26-18)10-2-1-3-12-15(10)24-17(23-12)11(20)8-29/h1-5,11,22,29H,6-8,19-20H2,(H2,21,30,31)/b10-9+/t11-/m1/s1 TXRDLFRTEYNPJV-PBQZMEPESA-N 361173 (S)-4-(2-(1-amino-2-hydroxyethyl)-1H-benzo[d]imidazol-4-yl)-N1-(2-aminoethyl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 330::US10544130, Example 330 Metallo-beta-lactamase type 2 2.76 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361173 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361173&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269252 386400563 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713884 NCCNS(=O)(=O)c1ccc(-c2cccc3[nH]c(nc23)[C@@H](N)CO)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C18H20N10O5S2/c19-6-7-22-35(32,33)13-5-4-9(14(16(13)34(21,30)31)18-25-27-28-26-18)10-2-1-3-12-15(10)24-17(23-12)11(20)8-29/h1-5,11,22,29H,6-8,19-20H2,(H2,21,30,31)/b10-9+/t11-/m0/s1 TXRDLFRTEYNPJV-USKTWTLRSA-N 361174 (R)-4-(2-(1-amino-2-hydroxyethyl)-1H-benzo[d] imidazol-4-yl)-N1-(2-aminoethyl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 331::US10544130, Example 331 Metallo-beta-lactamase type 2 2.28 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361174 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361174&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269253 386400564 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713887 NCCNS(=O)(=O)c1ccc(-c2cccc(C(=O)NC[C@@H](N)CO)c2N)c(-c2nn[nH]n2)c1S(N)(=O)=O 361175 (R)-2-amino-N-(2-amino-3-hydroxypropyl)-4′-(N-(2-aminoethyl)sulfamoyl)-3′-sulfamoyl-2′-(2H-tetrazol-5-yl-[1,1′-biphenyl]-3-carboxamide::US10221163, Example 332::US10544130, Example 332 Metallo-beta-lactamase type 2 3.00 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361175 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361175&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269254 386400565 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713890 NCCNS(=O)(=O)c1ccc(-c2cccc(C(=O)NC[C@H](N)CO)c2N)c(-c2nn[nH]n2)c1S(N)(=O)=O 361176 (S)-2-amino-N-(2-amino-3-hydroxypropyl)-4′-(N-(2-aminoethyl)sulfamoyl)-3′-sulfamoyl-2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-3-carboxamide::US10221163, Example 333::US10544130, Example 333 Metallo-beta-lactamase type 2 3.21 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361176 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361176&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269255 386400566 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713893 NCCNC(=O)c1cccc(c1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)NCCN InChI=1S/C18H23N9O5S2/c19-6-8-22-18(28)12-3-1-2-11(10-12)13-4-5-14(34(31,32)23-9-7-20)16(33(21,29)30)15(13)17-24-26-27-25-17/h1-5,10,23H,6-9,19-20H2,(H,22,28)(H2,21,29,30)(H,24,25,26,27) QPZMHHDLQNWPAO-UHFFFAOYSA-N 361177 N-(2-aminoethyl)-4′-(N-(2-aminoethyl)sulfamoyl)-3′-sulfamoyl-2′-(2H -tetrazol-5-yl)-[1,1′-biphenyl]-3-carboxamide::US10221163, Example 334::US10544130, Example 334 Metallo-beta-lactamase type 2 4.60 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361177 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361177&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269256 386400567 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713896 NCCNS(=O)(=O)c1ccc(-c2cccc3[nH]c(nc23)[C@H](N)CN)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C18H21N11O4S2/c19-6-7-23-35(32,33)13-5-4-9(14(16(13)34(22,30)31)18-26-28-29-27-18)10-2-1-3-12-15(10)25-17(24-12)11(21)8-20/h1-5,11,23H,6-8,19-21H2,(H2,22,30,31)/b10-9+/t11-/m1/s1 NLRLVEZYFRBSKE-PBQZMEPESA-N 361178 (R)—N1-(2-aminoethyl)-4-(2-(1,2-diaminoethyl)-1H-benzo[d]imidazole-4-yl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 335::US10544130, Example 335 Metallo-beta-lactamase type 2 4.78 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361178 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361178&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269257 386400568 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713899 NCCNS(=O)(=O)c1ccc(-c2cccc3[nH]c(nc23)[C@@H](N)CN)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C18H21N11O4S2/c19-6-7-23-35(32,33)13-5-4-9(14(16(13)34(22,30)31)18-26-28-29-27-18)10-2-1-3-12-15(10)25-17(24-12)11(21)8-20/h1-5,11,23H,6-8,19-21H2,(H2,22,30,31)/b10-9+/t11-/m0/s1 NLRLVEZYFRBSKE-USKTWTLRSA-N 361179 (S)—N1-(2-aminoethyl)-4-(2-(1,2-diaminoethyl)-1H-benzo[d]imidazol-4-yl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 336::US10544130, Example 336 Metallo-beta-lactamase type 2 2.90 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361179 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361179&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269258 386400569 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713902 NCCNS(=O)(=O)c1ccc(-c2cccc3[nH]c(CCN)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C18H22N10O4S2/c19-7-6-14-23-12-3-1-2-11(16(12)24-14)10-4-5-13(34(31,32)22-9-8-20)17(33(21,29)30)15(10)18-25-27-28-26-18/h1-5,22H,6-9,19-20H2,(H,23,24)(H2,21,29,30)(H,25,26,27,28) UITXDZUIOMRDEF-UHFFFAOYSA-N 361180 N1-(2-aminoethyl)-4-(2-(2-aminoethyl)-1H-benzo[d]imidazol-4-yl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 337::US10544130, Example 337 Metallo-beta-lactamase type 2 2.23 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361180 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361180&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269259 386400570 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713905 NCCNS(=O)(=O)c1ccc(C2=CC(N)CCC2)c(-c2nn[nH]n2)c1S(N)(=O)=O 361181 5′-Amino-N4-(2-aminoethyl)-2-(2H-tetrazol-5-yl)-2′,3′,4′,5′-tetrahydro-[1,1′-biphenyl]-3,4-disulfonamide::US10221163, Example 338::US10544130, Example 338 Metallo-beta-lactamase type 2 91.0 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361181 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361181&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124158414 386400571 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713908 N[C@@H]1CCCC(=C1)c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)N[C@@H]1CCNC1 InChI=1S/C17H24N8O4S2/c18-11-3-1-2-10(8-11)13-4-5-14(31(28,29)23-12-6-7-20-9-12)16(30(19,26)27)15(13)17-21-24-25-22-17/h4-5,8,11-12,20,23H,1-3,6-7,9,18H2,(H2,19,26,27)(H,21,22,24,25)/t11-,12-/m1/s1 IMWXDQXYXIFOOQ-VXGBXAGGSA-N 361182 (R)-5′-amino-N4-((R)-pyrrolidin-3-yl)-2-(2H-tetrazol-5-yl)-2′,3′,4′,5′-tetrahydro-[1,1′-biphenyl]-3,4-disulfonamide::US10221163, Example 339 Metallo-beta-lactamase type 2 34.1 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361182 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361182&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124158314 386400572 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713911 N[C@H]1CCCC(=C1)c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)N[C@@H]1CCNC1 InChI=1S/C17H24N8O4S2/c18-11-3-1-2-10(8-11)13-4-5-14(31(28,29)23-12-6-7-20-9-12)16(30(19,26)27)15(13)17-21-24-25-22-17/h4-5,8,11-12,20,23H,1-3,6-7,9,18H2,(H2,19,26,27)(H,21,22,24,25)/t11-,12+/m0/s1 IMWXDQXYXIFOOQ-NWDGAFQWSA-N 361183 (S)-5′-amino-N4-((R)-pyrrolidin-3-yl)-2-(2H-tetrazol-5-yl)-2′,3′,4′,5′-tetrahydro-[1,1′-biphenyl]-3,4-disulfonamide::US10221163, Example 340::US10544130, Example 340 Metallo-beta-lactamase type 2 46.7 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361183 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361183&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124158270 386400573 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713914 NCCCNC(=O)c1cccc(c1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)NCCN InChI=1S/C19H25N9O5S2/c20-7-2-9-23-19(29)13-4-1-3-12(11-13)14-5-6-15(35(32,33)24-10-8-21)17(34(22,30)31)16(14)18-25-27-28-26-18/h1,3-6,11,24H,2,7-10,20-21H2,(H,23,29)(H2,22,30,31)(H,25,26,27,28) CHZMHLGFIPQNHF-UHFFFAOYSA-N 361184 4′-(N-(2-aminoethyl)sulfamoyl)-N-(3-aminopropyl)-3′-sulfamoyl-2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-3-carboxamide::US10221163, Example 341::US10544130, Example 341 Metallo-beta-lactamase type 2 4.13 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361184 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361184&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269260 386400574 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713917 NCCNS(=O)(=O)c1ccc(C2CCC[C@H](N)C2)c(-c2nn[nH]n2)c1S(N)(=O)=O 361185 4-((3S)-3-aminocyclohexyl)-N1-(2-aminoethyl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 342::US10544130, Example 342 Metallo-beta-lactamase type 2 88.7 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361185 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361185&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124158348 386400575 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713920 NCCNS(=O)(=O)c1ccc(-c2cccc3[nH]c(CN)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C17H20N10O4S2/c18-6-7-21-33(30,31)12-5-4-9(10-2-1-3-11-15(10)23-13(8-19)22-11)14(16(12)32(20,28)29)17-24-26-27-25-17/h1-5,21H,6-8,18-19H2,(H,22,23)(H2,20,28,29)(H,24,25,26,27) WEEQPBCMGHANSA-UHFFFAOYSA-N 361186 N1-(2-aminoethyl)-4-(2-(aminomethyl)-1H-benzo[d]imidazol-4-yl-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 343::US10544130, Example 343 Metallo-beta-lactamase type 2 1.37 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361186 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361186&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135310772 386400576 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713125 COc1ccc(CN(Cc2ccc(OC)cc2)S(=O)(=O)c2c(ccc(I)c2-c2nnn(Cc3ccc(OC)cc3)n2)S(=O)(=O)NC[C@H]2CN(CCN2C(=O)OC(C)(C)C)C(=O)OC(C)(C)C)cc1 InChI=1S/C46H57IN8O11S2/c1-45(2,3)65-43(56)52-24-25-54(44(57)66-46(4,5)6)34(30-52)26-48-67(58,59)39-23-22-38(47)40(42-49-51-55(50-42)29-33-14-20-37(64-9)21-15-33)41(39)68(60,61)53(27-31-10-16-35(62-7)17-11-31)28-32-12-18-36(63-8)19-13-32/h10-23,34,48H,24-30H2,1-9H3/t34-/m0/s1 CQVYWECRQQVMBR-UMSFTDKQSA-N 360921 (R)-di-tert-butyl 2-((2-(N,N- bis(4-methoxybenzyl)sulfamoyl)- 4-iodo-3-(2-(4-methoxybenzyl)- 2H-tetrazol-5- yl)phenylsulfonamido)methyl) piperazine-1,4-dicarboxylate::US10221163, Example 77::US10544130, Example 77 Metallo-beta-lactamase type 2 0.166 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360921 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360921&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124158315 386400314 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713128 COc1ccc(CN(Cc2ccc(OC)cc2)S(=O)(=O)c2c(ccc(I)c2-c2nnn(Cc3ccc(OC)cc3)n2)S(=O)(=O)NC[C@H](CNC(=O)OCc2ccccc2)NC(=O)OC(C)(C)C)cc1 InChI=1S/C47H53IN8O11S2/c1-47(2,3)67-46(58)51-36(26-49-45(57)66-31-35-10-8-7-9-11-35)27-50-68(59,60)41-25-24-40(48)42(44-52-54-56(53-44)30-34-16-22-39(65-6)23-17-34)43(41)69(61,62)55(28-32-12-18-37(63-4)19-13-32)29-33-14-20-38(64-5)21-15-33/h7-25,36,50H,26-31H2,1-6H3,(H,49,57)(H,51,58)/t36-/m0/s1 SZMQVONRDOVLLM-BHVANESWSA-N 360922 (S)-benzyl tert-butyl (3-(2-(N,N- bis(4-methoxybenzyl)sulfamoyl)- 4-iodo-3-(2-(4-methoxybenzyl)- 2H-tetrazol-5- yl)phenylsulfonamido)propane- 1,2-diyl)dicarbamate::US10221163, Example 78::US10544130, Example 78 Metallo-beta-lactamase type 2 0.234 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360922 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360922&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269193 386400315 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713131 COc1ccc(CN(Cc2ccc(OC)cc2)S(=O)(=O)c2c(ccc(I)c2-c2nnn(Cc3ccc(OC)cc3)n2)S(=O)(=O)N[C@@H](CO)CNC(=O)OC(C)(C)C)cc1 InChI=1S/C39H46IN7O10S2/c1-39(2,3)57-38(49)41-21-29(25-48)44-58(50,51)34-20-19-33(40)35(37-42-45-47(43-37)24-28-11-17-32(56-6)18-12-28)36(34)59(52,53)46(22-26-7-13-30(54-4)14-8-26)23-27-9-15-31(55-5)16-10-27/h7-20,29,44,48H,21-25H2,1-6H3,(H,41,49)/t29-/m1/s1 PKIKBIFPRCUBFS-GDLZYMKVSA-N 360923 (R)-tert-butyl (2-(2-(N,N-bis(4- methoxybenzyl)sulfamoyl)-4- iodo-3-(2-(4-methoxybenzyl)- 2H-tetrazol-5- yl)phenylsulfonamido)-3- hydroxypropyl)carbamate::US10221163, Example 79::US10544130, Example 79 Metallo-beta-lactamase type 2 0.283 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360923 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360923&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269194 386400316 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713134 COc1ccc(CN(Cc2ccc(OC)cc2)S(=O)(=O)c2c(ccc(I)c2-c2nnn(Cc3ccc(OC)cc3)n2)S(=O)(=O)NC[C@H](CO)NC(=O)OCc2ccccc2)cc1 InChI=1S/C42H44IN7O10S2/c1-57-34-15-9-29(10-16-34)24-49(25-30-11-17-35(58-2)18-12-30)62(55,56)40-38(61(53,54)44-23-33(27-51)45-42(52)60-28-32-7-5-4-6-8-32)22-21-37(43)39(40)41-46-48-50(47-41)26-31-13-19-36(59-3)20-14-31/h4-22,33,44,51H,23-28H2,1-3H3,(H,45,52)/t33-/m1/s1 XGFAJSGBLMHBHK-MGBGTMOVSA-N 360924 (R)-benzyl (1-(2-(N,N-bis(4- methoxybenzyl)sulfamoyl)-4- iodo-3-(2-(4-methoxybenzyl)- 2H-tetrazol-5- yl)phenylsulfonamido)-3- hydroxypropan-2-yl)carbamate::US10221163, Example 80::US10544130, Example 80 Metallo-beta-lactamase type 2 0.336 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360924 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360924&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269195 386400317 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713137 COc1ccc(CN(Cc2ccc(OC)cc2)S(=O)(=O)c2c(ccc(I)c2-c2nnn(Cc3ccc(OC)cc3)n2)S(=O)(=O)NC[C@@H](CNC(=O)OC(C)(C)C)NC(=O)OC(C)(C)C)cc1 InChI=1S/C44H55IN8O11S2/c1-43(2,3)63-41(54)46-24-32(48-42(55)64-44(4,5)6)25-47-65(56,57)37-23-22-36(45)38(40-49-51-53(50-40)28-31-14-20-35(62-9)21-15-31)39(37)66(58,59)52(26-29-10-16-33(60-7)17-11-29)27-30-12-18-34(61-8)19-13-30/h10-23,32,47H,24-28H2,1-9H3,(H,46,54)(H,48,55)/t32-/m1/s1 MPKFPGZSQMILTQ-JGCGQSQUSA-N 360925 (R)-di-tert-butyl (3-(2-(N,N- bis(4-methoxybenzyl)sulfamoyl)- 4-iodo-3-(2-(4-methoxybenzyl)- 2H-tetrazol-5- yl)phenylsulfonamido)propane- 1,2-diyl)dicarbamate::US10221163, Example 81::US10544130, Example 81 Metallo-beta-lactamase type 2 0.191 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360925 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360925&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269196 386400318 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713140 COc1ccc(CN(Cc2ccc(OC)cc2)S(=O)(=O)c2c(ccc(I)c2-c2nnn(Cc3ccc(OC)cc3)n2)S(=O)(=O)N[C@@H]2CN(C[C@@H]2NC(=O)OC(C)(C)C)C(=O)OC(C)(C)C)cc1 InChI=1S/C45H55IN8O11S2/c1-44(2,3)64-42(55)47-36-27-52(43(56)65-45(4,5)6)28-37(36)50-66(57,58)38-23-22-35(46)39(41-48-51-54(49-41)26-31-14-20-34(63-9)21-15-31)40(38)67(59,60)53(24-29-10-16-32(61-7)17-11-29)25-30-12-18-33(62-8)19-13-30/h10-23,36-37,50H,24-28H2,1-9H3,(H,47,55)/t36-,37+/m0/s1 IAQXVQLDCFUFMS-PQQNNWGCSA-N 360926 (3R,4S)-tert-butyl 3-(2-(N,N- bis(4-methoxybenzyl)sulfamoyl)- 4-iodo-3-(2-(4-methoxybenzyl)- 2H-tetrazol-5- yl)phenylsulfonamido)-4-((tert- butoxycarbonyl)amino) pyrrolidine-1-carboxylate::US10221163, Example 82 Metallo-beta-lactamase type 2 0.206 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360926 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360926&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311209 386400319 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713143 COc1ccc(CN(Cc2ccc(OC)cc2)S(=O)(=O)c2c(ccc(I)c2-c2nnn(Cc3ccc(OC)cc3)n2)S(=O)(=O)N[C@H](CO)CNC(=O)OCc2ccccc2)cc1 InChI=1S/C42H44IN7O10S2/c1-57-34-15-9-29(10-16-34)24-49(25-30-11-17-35(58-2)18-12-30)62(55,56)40-38(61(53,54)47-33(27-51)23-44-42(52)60-28-32-7-5-4-6-8-32)22-21-37(43)39(40)41-45-48-50(46-41)26-31-13-19-36(59-3)20-14-31/h4-22,33,47,51H,23-28H2,1-3H3,(H,44,52)/t33-/m0/s1 HFKRWXOBVDJOSJ-XIFFEERXSA-N 360927 (S)-benzyl (2-(2-(N,N-bis(4- methoxybenzyl)sulfamoyl)-4- iodo-3-(2-(4-methoxybenzyl)- 2H-tetrazol-5- yl)phenylsulfonamido)-3- hydroxypropyl)carbamate::US10221163, Example 83 Metallo-beta-lactamase type 2 0.261 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360927 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360927&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269197 386400320 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713146 COc1ccc(CN(Cc2ccc(OC)cc2)S(=O)(=O)c2c(ccc(I)c2-c2nnn(Cc3ccc(OC)cc3)n2)S(=O)(=O)NC(CNC(=O)OC(C)(C)C)CNC(=O)OC(C)(C)C)cc1 InChI=1S/C44H55IN8O11S2/c1-43(2,3)63-41(54)46-24-32(25-47-42(55)64-44(4,5)6)50-65(56,57)37-23-22-36(45)38(40-48-51-53(49-40)28-31-14-20-35(62-9)21-15-31)39(37)66(58,59)52(26-29-10-16-33(60-7)17-11-29)27-30-12-18-34(61-8)19-13-30/h10-23,32,50H,24-28H2,1-9H3,(H,46,54)(H,47,55) QVKQWKSQEZEBGV-UHFFFAOYSA-N 360928 US10221163, Example 84::US10544130, Example 84::di-tert-butyl (2-(2-(N,N-bis(4- methoxybenzyl)sulfamoyl)-4- iodo-3-(2-(4-methoxybenzyl)- 2H-tetrazol-5- yl)phenylsulfonamido)propane- 1,3-diyl)dicarbamate Metallo-beta-lactamase type 2 0.403 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360928 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360928&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311148 386400321 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713149 COCCNCCNS(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nnn[nH]2)c1S(N)(=O)=O InChI=1S/C19H23N9O5S3/c1-33-10-9-22-7-8-23-36(31,32)14-6-5-11(12-3-2-4-13-16(12)24-19(20)34-13)15(17(14)35(21,29)30)18-25-27-28-26-18/h2-6,22-23H,7-10H2,1H3,(H2,20,24)(H2,21,29,30)(H,25,26,27,28) PLAHRQCCYRURRB-UHFFFAOYSA-N 360929 4-(2- aminobenzo [d]thiazol- 4-yl)-N1-(2-((2- methoxyethyl) amino)ethyl)-3- (1H-tetrazol-5- yl)benzene-1,2- disulfonamide::US10221163, Example 85 Metallo-beta-lactamase type 2 0.205 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360929 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360929&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311232 386400322 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713152 Nc1nc2c(cccc2s1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)NCC1(O)CCNCC1 InChI=1S/C20H23N9O5S3/c21-19-25-16-12(2-1-3-13(16)35-19)11-4-5-14(17(36(22,31)32)15(11)18-26-28-29-27-18)37(33,34)24-10-20(30)6-8-23-9-7-20/h1-5,23-24,30H,6-10H2,(H2,21,25)(H2,22,31,32)(H,26,27,28,29) LHGHDVNQBZMSRJ-UHFFFAOYSA-N 360930 4-(2- aminobenzo [d]thiazol- 4-yl)-N1-((4- hydroxypiperidin- 4-yl)methyl)- 3-(1H- tetrazol-5-yl) benzene-1,2- disulfonamide::US10221163, Example 86::US10544130, Example 86 Metallo-beta-lactamase type 2 0.129 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360930 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360930&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311714 386400323 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713155 CC(C)(N)CNS(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nnn[nH]2)c1S(N)(=O)=O InChI=1S/C18H21N9O4S3/c1-18(2,20)8-22-34(30,31)12-7-6-9(10-4-3-5-11-14(10)23-17(19)32-11)13(15(12)33(21,28)29)16-24-26-27-25-16/h3-7,22H,8,20H2,1-2H3,(H2,19,23)(H2,21,28,29)(H,24,25,26,27) LDXPTSONMCDLJU-UHFFFAOYSA-N 360931 N1-(2-amino-2- methylpropyl)- 4-(2-aminobenzo [d]thiazol- 4-yl)-3-(1H- tetrazol-5- yl)benzene-1,2- disulfonamide::US10221163, Example 87::US10544130, Example 87 Metallo-beta-lactamase type 2 0.261 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360931 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360931&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135312016 386400324 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713158 Nc1nc2c(cccc2s1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)NC1CC2CNC1C2 360932 4-(2-aminobenzo [d]thiazol-4-yl)- N1-(2-azabicyclo [2.2.1]heptan- 6-yl)-3-(1H- tetrazol-5- yl)benzene-1,2- disulfonamide::US10221163, Example 88::US10221163, Example 89::US10544130, Example 89 Metallo-beta-lactamase type 2 0.172 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360932 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360932&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311710 386400325 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713161 Nc1nc2c(cccc2s1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)NC1CC2CNC1C2 360932 4-(2-aminobenzo [d]thiazol-4-yl)- N1-(2-azabicyclo [2.2.1]heptan- 6-yl)-3-(1H- tetrazol-5- yl)benzene-1,2- disulfonamide::US10221163, Example 88::US10221163, Example 89::US10544130, Example 89 Metallo-beta-lactamase type 2 0.568 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360932 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360932&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311710 386400325 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713164 NCCCNS(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nnn[nH]2)c1S(N)(=O)=O InChI=1S/C17H19N9O4S3/c18-7-2-8-21-33(29,30)12-6-5-9(10-3-1-4-11-14(10)22-17(19)31-11)13(15(12)32(20,27)28)16-23-25-26-24-16/h1,3-6,21H,2,7-8,18H2,(H2,19,22)(H2,20,27,28)(H,23,24,25,26) CRRHXDQIJGYZET-UHFFFAOYSA-N 360934 3-(4-(2- aminobenzo [d]thiazol-4-yl)- 2-sulfamoyl-3- (1H-tetrazol-5- yl)phenyl- sulfonamido) propan-1- aminium 2,2,2- trifluoroacetate::US10221163, Example 90::US10544130, Example 90 Metallo-beta-lactamase type 2 0.411 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360934 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360934&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311755 386400326 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713167 Nc1nc2c(cccc2s1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)NCC1(F)CNC1 InChI=1S/C18H18FN9O4S3/c19-18(6-22-7-18)8-23-35(31,32)12-5-4-9(10-2-1-3-11-14(10)24-17(20)33-11)13(15(12)34(21,29)30)16-25-27-28-26-16/h1-5,22-23H,6-8H2,(H2,20,24)(H2,21,29,30)(H,25,26,27,28) FBOXLDIWBOPBGH-UHFFFAOYSA-N 360890 4-(2-amino-1,3- benzothiazol-4-yl)-N1-[(3- fluoroazetidin-3- yl)methyl]-3-(1H-tetrazol- 5-yl)benzene-1,2- disulfonamide::US10221163, Example 46::US10221163, Example 91::US10544130, Example 91 Metallo-beta-lactamase type 2 0.326 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360890 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360890&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311332 386400283 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713170 Nc1nc2c(cccc2s1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)N1CCN(CCO)CC1 InChI=1S/C20H23N9O5S3/c21-20-23-17-13(2-1-3-14(17)35-20)12-4-5-15(18(36(22,31)32)16(12)19-24-26-27-25-19)37(33,34)29-8-6-28(7-9-29)10-11-30/h1-5,30H,6-11H2,(H2,21,23)(H2,22,31,32)(H,24,25,26,27) ASHSVVZOBGBBQZ-UHFFFAOYSA-N 360936 4-((4-(2- aminobenzo [d]thiazol-4-yl)-2- sulfamoyl-3- (1H-tetrazol-3- yl)phenyl) sulfonyl)-1-(2- hydroxyethyl) piperazin- 1-ium 2,2,2- trifluoroacetate::US10221163, Example 92::US10544130, Example 92 Metallo-beta-lactamase type 2 1.17 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360936 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360936&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 137537573 386400327 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713173 CNCCCNS(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nnn[nH]2)c1S(=O)(=O)NC InChI=1S/C19H23N9O4S3/c1-21-9-4-10-23-34(29,30)14-8-7-11(12-5-3-6-13-16(12)24-19(20)33-13)15(18-25-27-28-26-18)17(14)35(31,32)22-2/h3,5-8,21-23H,4,9-10H2,1-2H3,(H2,20,24)(H,25,26,27,28) VGBOLCLKMFLUKX-UHFFFAOYSA-N 360937 3-(4-(2- aminobenzo [d]thiazol-4-yl)-N- methyl-2-sulfamoyl- 3-(1H-tetrazol-5- yl)phenyl- sulfonamido)-N- methylpropan-1- aminium 2,2,2- trifluoroacetate::US10221163, Example 93 Metallo-beta-lactamase type 2 5.29 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360937 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360937&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269198 386400328 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713176 NC[C@@H]1CCN(C1)S(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nnn[nH]2)c1S(N)(=O)=O 360914 3-(2-amino-1,3- benzothiazol-4-yl)-6- {[(3S)-3- (aminomethyl)pyrrolidin- 1-yl]sulfonyl}-2-(1H- tetrazol-5- yl)benzenesulfonamide::US10221163, Example 70::US10221163, Example 94::US10544130, Example 94 Metallo-beta-lactamase type 2 0.730 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360914 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360914&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311199 386400307 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713179 NC1CC2OC1CCC2NS(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nnn[nH]2)c1S(N)(=O)=O 360939 2-(4-(2- aminobenzo [d]thiazol-4-yl)-2- sulfamoyl-3- (1H-tetrazol-5- yl)phenyl- sulfonamido)-8- oxabicyclo[3.2.1] octan-6-aminium 2,2,2- trifluoroacetate::US10221163, Example 95::US10544130, Example 95 Metallo-beta-lactamase type 2 0.193 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360939 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360939&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135310742 386400329 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713182 Nc1nc2c(cccc2s1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)NCC1COCCN1 360940 3-((4-(2- aminobenzo [d]thiazol-4-yl)-2- sulfamoyl-3- (1H-tetrazol-5-yl) phenylsulfonamido) methyl)morpholin-4- ium 2,2,2- trifluoroacetate::US10221163, Example 96::US10544130, Example 96 Metallo-beta-lactamase type 2 0.402 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360940 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360940&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311727 386400330 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713923 NCCNS(=O)(=O)c1ccc(-c2cccc(c2)C(=O)N[C@@H]2CNC[C@H]2O)c(-c2nn[nH]n2)c1S(N)(=O)=O 361187 4′-(N-(2-aminoethyl)sulfamoyl)-N-((3R,4R)-4-hydroxypyrrolidin-3-yl)-3′-sulfamoyl-2′-(2H-tetrazol-5-yl-[1,1′-biphenyl]-3-carboxamide::US10221163, Example 344::US10544130, Example 344 Metallo-beta-lactamase type 2 4.26 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361187 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361187&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124158227 386400577 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713926 NCCNS(=O)(=O)c1ccc(-c2cccc3sc(CN)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C17H19N9O4S3/c18-6-7-21-33(29,30)12-5-4-9(10-2-1-3-11-15(10)22-13(8-19)31-11)14(16(12)32(20,27)28)17-23-25-26-24-17/h1-5,21H,6-8,18-19H2,(H2,20,27,28)(H,23,24,25,26) MDKTUBIZBKMCTP-UHFFFAOYSA-N 361188 N1-(2-aminoethyl)-4-(2-(aminomethyl)benzo[d]thiazol-4-yl)-3-(2H -tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 345::US10544130, Example 345 Metallo-beta-lactamase type 2 0.676 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361188 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361188&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311461 386400578 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713929 NCCNS(=O)(=O)c1ccc(-c2cccc(c2)C(=O)NC[C@H](O)CN)c(-c2nn[nH]n2)c1S(N)(=O)=O 361189 (R)—N-(3-amino-2-hydroxypropyl)-4′-(N-(2-aminoethyl)sulfamoyl)-3′-sulfamoyl-2′-(2H-tetrazol-5-yl-[1,1′-biphenyl]-3-carboxamide::US10221163, Example 346::US10221163, Example 347::US10544130, Example 347 Metallo-beta-lactamase type 2 3.65 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361189 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361189&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311707 386400579 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713932 NCCNS(=O)(=O)c1ccc(-c2cccc(c2)C(=O)NC[C@H](O)CN)c(-c2nn[nH]n2)c1S(N)(=O)=O 361189 (R)—N-(3-amino-2-hydroxypropyl)-4′-(N-(2-aminoethyl)sulfamoyl)-3′-sulfamoyl-2′-(2H-tetrazol-5-yl-[1,1′-biphenyl]-3-carboxamide::US10221163, Example 346::US10221163, Example 347::US10544130, Example 347 Metallo-beta-lactamase type 2 3.97 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361189 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361189&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311707 386400579 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713935 NCCNS(=O)(=O)c1ccc(-c2ccc3ncn(CCN)c3c2)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C18H22N10O4S2/c19-5-7-23-34(31,32)15-4-2-12(16(17(15)33(21,29)30)18-24-26-27-25-18)11-1-3-13-14(9-11)28(8-6-20)10-22-13/h1-4,9-10,23H,5-8,19-20H2,(H2,21,29,30)(H,24,25,26,27) NUGIVIRZGIFIKC-UHFFFAOYSA-N 361191 N1-(2-aminoethyl)-4-(1-(2-aminoethyl)-1H-benzo[d]imidazol-6-yl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 348::US10544130, Example 348 Metallo-beta-lactamase type 2 3.33 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361191 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361191&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311029 386400580 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713938 NCCNS(=O)(=O)c1ccc(-c2cccc(NC[C@@H](N)CO)c2)c(-c2nn[nH]n2)c1S(N)(=O)=O 361192 (R)-3'-((2-amino-3- hydroxypropyl) amino)-N4-(2- aminoethyl)-2-(2H- tetrazol-5-yl)-[1,1'- biphenyl]-3,4- disulfonamide::US10221163, Example 349::US10544130, Example 349 Metallo-beta-lactamase type 2 5.65 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361192 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361192&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269261 386400581 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713941 NCCNS(=O)(=O)c1ccc(-c2cccc(NC[C@H](N)CO)c2)c(-c2nn[nH]n2)c1S(N)(=O)=O 361193 (S)-3'-((2-amino-3- hydroxypropyl) amino)-N4-(2- aminoethyl)-2-(2H- tetrazol-5-yl)-[1,1'- biphenyl]-3,4- disulfonamide::US10221163, Example 350::US10544130, Example 350 Metallo-beta-lactamase type 2 4.40 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361193 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361193&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269262 386400582 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713944 NCCNS(=O)(=O)c1ccc(-c2cccc(NC[C@H](O)CN)c2)c(-c2nn[nH]n2)c1S(N)(=O)=O 361194 (R)-3'-((3-amino-2- hydroxypropyl) amino)-N4-(2- aminoethyl)-2-(2H- tetrazol-5-yl)-[1,1'- biphenyl]-3,4- disulfonamide::US10221163, Example 351::US10544130, Example 351 Metallo-beta-lactamase type 2 3.55 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361194 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361194&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269263 386400583 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713947 NCCNS(=O)(=O)c1ccc(-c2cccc(NC[C@@H](O)CN)c2)c(-c2nn[nH]n2)c1S(N)(=O)=O 361195 (S)-3'-((3-amino-2- hydroxypropyl) amino)N4-(2- aminoethyl)-2-(2H- tetrazol-5-yl)-[1,1'- biphenyl]-3,4- disulfonamide::US10221163, Example 352::US10544130, Example 352 Metallo-beta-lactamase type 2 4.39 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361195 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361195&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269264 386400584 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713950 NCCNS(=O)(=O)c1ccc(-c2cccc(c2)-c2c[nH]c(N)n2)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C18H20N10O4S2/c19-6-7-23-34(31,32)14-5-4-12(15(16(14)33(21,29)30)17-25-27-28-26-17)10-2-1-3-11(8-10)13-9-22-18(20)24-13/h1-5,8-9,23H,6-7,19H2,(H3,20,22,24)(H2,21,29,30)(H,25,26,27,28) WNEHLMHMEYRECK-UHFFFAOYSA-N 361196 3'-(2-amino-1H- imidazol-4-yl)-N4- (2-aminoethyl)-2- (2H-tetrazol-5-yl)- [1,1'-biphenyl]-3,4- disulfonamide::US10221163, Example 353::US10544130, Example 353 Metallo-beta-lactamase type 2 1.15 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361196 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361196&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269265 386400585 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713953 NCCNS(=O)(=O)c1ccc(-c2cccc(SCC(N)CO)c2)c(-c2nn[nH]n2)c1S(N)(=O)=O 361197 3'-((2-amino-3- hydroxypropyl)thio)- N4-(2-aminoethyl)- 2-(2H-tetrazol-5-yl)- [1,1'-biphenyl]-3,4- disulfonamide::US10221163, Example 354::US10544130, Example 354 Metallo-beta-lactamase type 2 0.453 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361197 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361197&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269266 386400586 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713956 NCCNS(=O)(=O)c1ccc(-c2cccc3ccc(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C18H19N9O4S2/c19-8-9-22-33(30,31)13-6-5-11(12-3-1-2-10-4-7-14(20)23-16(10)12)15(17(13)32(21,28)29)18-24-26-27-25-18/h1-7,22H,8-9,19H2,(H2,20,23)(H2,21,28,29)(H,24,25,26,27) XQMXOQCDPKRVCW-UHFFFAOYSA-N 361198 N1-(2-aminoethyl)- 4-(2-aminoquinolin- 8-yl)-3-(2H-tetrazol- 5-yl)benzene-1,2- disulfonamide::US10221163, Example 355::US10544130, Example 355 Metallo-beta-lactamase type 2 0.200 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361198 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361198&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269267 386400587 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713959 NCCNS(=O)(=O)c1ccc(-c2cccc(SC[C@H](O)CN)c2)c(-c2nn[nH]n2)c1S(N)(=O)=O 361199 (R)-3'-((3-amino-2- hydroxypropyl)thio)- N4-(2-aminoethyl)- 2-(2H-tetrazol-5-yl)- [1,1'-biphenyl]-3,4- disulfonamide::US10221163, Example 356::US10544130, Example 356 Metallo-beta-lactamase type 2 1.41 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361199 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361199&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269268 386400588 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713962 NCCNS(=O)(=O)c1ccc(-c2cccc(SC[C@@H](O)CN)c2)c(-c2nn[nH]n2)c1S(N)(=O)=O 361200 (S)-5'-(3-amino-2- hydroxypropylthio)- N4-(2-aminoethyl)- 2-(2H-tetrazol-5- yl)biphenyl-3,4- disulfonamide::US10221163, Example 357::US10544130, Example 357 Metallo-beta-lactamase type 2 1.21 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361200 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361200&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269269 386400589 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713965 NCCNS(=O)(=O)c1ccc(-c2cccnc2N)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C14H17N9O4S2/c15-5-7-19-29(26,27)10-4-3-8(9-2-1-6-18-13(9)16)11(12(10)28(17,24)25)14-20-22-23-21-14/h1-4,6,19H,5,7,15H2,(H2,16,18)(H2,17,24,25)(H,20,21,22,23) XULNQSBXNLRQGP-UHFFFAOYSA-N 361201 N1-(2-aminoethyl)- 4-(2-aminopyridin- 3-yl)-3-(2H-tetrazol- 5-yl)benzene-1,2- disulfonamide::US10221163, Example 358::US10544130, Example 358 Metallo-beta-lactamase type 2 4.05 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361201 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361201&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269270 386400590 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713968 NCCNS(=O)(=O)c1ccc(-c2cnc3cc[nH]c3c2)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C16H17N9O4S2/c17-4-6-21-31(28,29)13-2-1-10(9-7-12-11(20-8-9)3-5-19-12)14(15(13)30(18,26)27)16-22-24-25-23-16/h1-3,5,7-8,19,21H,4,6,17H2,(H2,18,26,27)(H,22,23,24,25) JTJBIUPVRAYOQB-UHFFFAOYSA-N 361202 N1-(2-aminoethyl)- 4-(1H-pyrrolo[3,2- b]pyridin-6-yl)-3- (2H-tetrazol-5- yl)benzene-1,2- disulfonamide::US10221163, Example 359::US10544130, Example 359 Metallo-beta-lactamase type 2 1.61 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361202 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361202&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269271 386400591 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713971 NCCNS(=O)(=O)c1ccc(-c2cncc3ncccc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C17H17N9O4S2/c18-5-7-22-32(29,30)14-4-3-11(12-8-20-9-13-10(12)2-1-6-21-13)15(16(14)31(19,27)28)17-23-25-26-24-17/h1-4,6,8-9,22H,5,7,18H2,(H2,19,27,28)(H,23,24,25,26) DMYGEDXWECZRLK-UHFFFAOYSA-N 361203 N1-(2-aminoethyl)- 4-(quinolin-5-yl)-3- (2H-tetrazol-5- yl)benzene-1,2- disulfonamide::US10221163, Example 360 Metallo-beta-lactamase type 2 0.381 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361203 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361203&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269272 386400592 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713974 NCCNS(=O)(=O)c1ccc(-c2cccn3ccnc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C16H17N9O4S2/c17-5-6-20-31(28,29)12-4-3-10(11-2-1-8-25-9-7-19-16(11)25)13(14(12)30(18,26)27)15-21-23-24-22-15/h1-4,7-9,20H,5-6,17H2,(H2,18,26,27)(H,21,22,23,24) ZUMVYUASFRNBGF-UHFFFAOYSA-N 361204 N1-(2-aminoethyl)- 4-(imidazo[1,2- a]pyridin-8-yl)-3- (2H-tetrazol-5- yl)benzene-1,2- disulfonamide::US10221163, Example 361::US10544130, Example 361 Metallo-beta-lactamase type 2 0.147 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361204 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361204&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311756 386400593 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713977 NC[C@H](CO)NS(=O)(=O)c1ccc(-c2ccnc(N)c2)c(-c2nn[nH]n2)c1S(N)(=O)=O 361205 (R)—N1-(1-amino-3-hydroxypropan-2-yl)-4-(2-aminopyridin-4-yl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 362::US10544130, Example 362 Metallo-beta-lactamase type 2 9.51 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361205 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361205&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311172 386400594 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 713980 NC[C@H](CO)NS(=O)(=O)c1ccc(-c2cccc3sc(CN)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O 361206 (R)—N1-(1-amino-3-hydroxypropan-2-yl)-4-(2-(aminomethyl)benzo[d]thiazol-4-yl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 363::US10544130, Example 363 Metallo-beta-lactamase type 2 3.67 US Patent 10.7270/Q2RX9FB1 aid1797825 US10221163 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361206 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361206&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135310682 386400595 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 51178558 Cc1ccc(cc1)-n1c(c(-c2ccccc2)c2c(Cl)ncnc12)-c1ccccc1 InChI=1S/C25H18ClN3/c1-17-12-14-20(15-13-17)29-23(19-10-6-3-7-11-19)21(18-8-4-2-5-9-18)22-24(26)27-16-28-25(22)29/h2-16H,1H3 DPTDSDGPGIFMFX-UHFFFAOYSA-N 50484372 CHEMBL1910736 Metallo-beta-lactamase type 2 19000 ChEMBL 10.1016/j.ejmech.2011.10.030 10.7270/Q26M39PH 22051063 Mohamed, MS; Hussein, WM; McGeary, RP; Vella, P; Schenk, G; Abd El-Hameed, RH Helwan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50484372 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50484372&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 56935233 433951637 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 51178559 Cc1ccc(cc1)-n1cc(-c2ccccc2)c2c(Cl)ncnc12 InChI=1S/C19H14ClN3/c1-13-7-9-15(10-8-13)23-11-16(14-5-3-2-4-6-14)17-18(20)21-12-22-19(17)23/h2-12H,1H3 YXFXRKMVZRLEBX-UHFFFAOYSA-N 50484373 CHEMBL1910738 Metallo-beta-lactamase type 2 33000 ChEMBL 10.1016/j.ejmech.2011.10.030 10.7270/Q26M39PH 22051063 Mohamed, MS; Hussein, WM; McGeary, RP; Vella, P; Schenk, G; Abd El-Hameed, RH Helwan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50484373 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50484373&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 2049551 433951638 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 51178560 Cc1ccc(cc1)-n1c(c(-c2ccccc2)c2c(N\N=C\c3ccccc3)ncnc12)-c1ccccc1 InChI=1S/C32H25N5/c1-23-17-19-27(20-18-23)37-30(26-15-9-4-10-16-26)28(25-13-7-3-8-14-25)29-31(33-22-34-32(29)37)36-35-21-24-11-5-2-6-12-24/h2-22H,1H3,(H,33,34,36)/b35-21+ FMBOWKPACVZVOT-XICOUIIWSA-N 50484374 CHEMBL1910740 Metallo-beta-lactamase type 2 18000 ChEMBL 10.1016/j.ejmech.2011.10.030 10.7270/Q26M39PH 22051063 Mohamed, MS; Hussein, WM; McGeary, RP; Vella, P; Schenk, G; Abd El-Hameed, RH Helwan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50484374 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50484374&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 56656256 433951639 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 51178561 Cc1ccc(cc1)-n1c(c(-c2ccccc2)c2c1ncn1c2n[nH]c1=S)-c1ccccc1 InChI=1S/C26H19N5S/c1-17-12-14-20(15-13-17)31-23(19-10-6-3-7-11-19)21(18-8-4-2-5-9-18)22-24(31)27-16-30-25(22)28-29-26(30)32/h2-16H,1H3,(H,29,32) MRAXOCUMJXOLQA-UHFFFAOYSA-N 50484375 CHEMBL1910741 Metallo-beta-lactamase type 2 15000 ChEMBL 10.1016/j.ejmech.2011.10.030 10.7270/Q26M39PH 22051063 Mohamed, MS; Hussein, WM; McGeary, RP; Vella, P; Schenk, G; Abd El-Hameed, RH Helwan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50484375 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50484375&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 56656257 433951640 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 51178562 COc1ccc(cc1)-n1c2N=CNC(=C(C#N)C#N)c2c(c1-c1ccccc1)-c1ccccc1 InChI=1S/C28H19N5O/c1-34-23-14-12-22(13-15-23)33-27(20-10-6-3-7-11-20)24(19-8-4-2-5-9-19)25-26(21(16-29)17-30)31-18-32-28(25)33/h2-15,18H,1H3,(H,31,32) MZJRTEQNJTUZCA-UHFFFAOYSA-N 50484376 CHEMBL1910739 Metallo-beta-lactamase type 2 29000 ChEMBL 10.1016/j.ejmech.2011.10.030 10.7270/Q26M39PH 22051063 Mohamed, MS; Hussein, WM; McGeary, RP; Vella, P; Schenk, G; Abd El-Hameed, RH Helwan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50484376 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50484376&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 56656258 433951641 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 51178563 COc1ccc(cc1)-n1c(c(-c2ccccc2)c2c(Cl)ncnc12)-c1ccccc1 InChI=1S/C25H18ClN3O/c1-30-20-14-12-19(13-15-20)29-23(18-10-6-3-7-11-18)21(17-8-4-2-5-9-17)22-24(26)27-16-28-25(22)29/h2-16H,1H3 JFTXWYIITCMHJC-UHFFFAOYSA-N 50484377 CHEMBL1910737 Metallo-beta-lactamase type 2 12000 ChEMBL 10.1016/j.ejmech.2011.10.030 10.7270/Q26M39PH 22051063 Mohamed, MS; Hussein, WM; McGeary, RP; Vella, P; Schenk, G; Abd El-Hameed, RH Helwan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50484377 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50484377&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 56656255 433951642 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 51178728 Sc1nnc([nH]1)-c1ccc(cc1)C(=O)c1ccccc1 InChI=1S/C15H11N3OS/c19-13(10-4-2-1-3-5-10)11-6-8-12(9-7-11)14-16-15(20)18-17-14/h1-9H,(H2,16,17,18,20) YOZFICAKUUCVET-UHFFFAOYSA-N 50484529 CHEMBL1935512 Metallo-beta-lactamase type 2 75000 ChEMBL 10.1016/j.bmcl.2011.10.116 10.7270/Q2D79F7P 22115595 Faridoon, na; Hussein, WM; Vella, P; Islam, NU; Ollis, DL; Schenk, G; McGeary, RP The University of Queensland http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50484529 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50484529&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 57398764 433951794 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 51178729 NC(S)=NNC(=O)c1ccccc1 InChI=1S/C8H9N3OS/c9-8(13)11-10-7(12)6-4-2-1-3-5-6/h1-5H,(H,10,12)(H3,9,11,13) OWKWAVBMKKZMHE-UHFFFAOYSA-N 50484530 CHEMBL1576619 Metallo-beta-lactamase type 2 19000 ChEMBL 10.1016/j.bmcl.2011.10.116 10.7270/Q2D79F7P 22115595 Faridoon, na; Hussein, WM; Vella, P; Islam, NU; Ollis, DL; Schenk, G; McGeary, RP The University of Queensland http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50484530 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50484530&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 781748 433951795 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 51178730 NC(=S)NNC(=O)c1ccc(cc1)C(=O)c1cccc(c1)[N+]([O-])=O InChI=1S/C15H12N4O4S/c16-15(24)18-17-14(21)10-6-4-9(5-7-10)13(20)11-2-1-3-12(8-11)19(22)23/h1-8H,(H,17,21)(H3,16,18,24) RWMPSNURTGYLPE-UHFFFAOYSA-N 50484531 CHEMBL1935524 Metallo-beta-lactamase type 2 16000 ChEMBL 10.1016/j.bmcl.2011.10.116 10.7270/Q2D79F7P 22115595 Faridoon, na; Hussein, WM; Vella, P; Islam, NU; Ollis, DL; Schenk, G; McGeary, RP The University of Queensland http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50484531 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50484531&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 57402246 433951796 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 51178731 Cc1ccc(cc1)C(=O)c1ccc(cc1)C(=O)NNC(N)=S InChI=1S/C16H15N3O2S/c1-10-2-4-11(5-3-10)14(20)12-6-8-13(9-7-12)15(21)18-19-16(17)22/h2-9H,1H3,(H,18,21)(H3,17,19,22) BHGRSMNPEQSDMT-UHFFFAOYSA-N 50484532 CHEMBL1935527 Metallo-beta-lactamase type 2 41000 ChEMBL 10.1016/j.bmcl.2011.10.116 10.7270/Q2D79F7P 22115595 Faridoon, na; Hussein, WM; Vella, P; Islam, NU; Ollis, DL; Schenk, G; McGeary, RP The University of Queensland http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50484532 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50484532&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 57400444 433951797 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 51178732 NC(=S)NNC(=O)c1ccc(cc1)C(=O)c1ccccc1 InChI=1S/C15H13N3O2S/c16-15(21)18-17-14(20)12-8-6-11(7-9-12)13(19)10-4-2-1-3-5-10/h1-9H,(H,17,20)(H3,16,18,21) GXTXVZQIVMRDAN-UHFFFAOYSA-N 50484533 CHEMBL1935522 Metallo-beta-lactamase type 2 13000 ChEMBL 10.1016/j.bmcl.2011.10.116 10.7270/Q2D79F7P 22115595 Faridoon, na; Hussein, WM; Vella, P; Islam, NU; Ollis, DL; Schenk, G; McGeary, RP The University of Queensland http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50484533 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50484533&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 57400443 433951798 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 51178733 NC(=S)NNC(=O)c1ccc(cc1)C(=O)c1ccccc1Cl InChI=1S/C15H12ClN3O2S/c16-12-4-2-1-3-11(12)13(20)9-5-7-10(8-6-9)14(21)18-19-15(17)22/h1-8H,(H,18,21)(H3,17,19,22) KZNLWBPLBIAWKK-UHFFFAOYSA-N 50484534 CHEMBL1935526 Metallo-beta-lactamase type 2 14000 ChEMBL 10.1016/j.bmcl.2011.10.116 10.7270/Q2D79F7P 22115595 Faridoon, na; Hussein, WM; Vella, P; Islam, NU; Ollis, DL; Schenk, G; McGeary, RP The University of Queensland http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50484534 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50484534&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 57391790 433951799 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 51178734 NC(=S)NNC(=O)c1ccc(Cc2ccccc2)cc1 InChI=1S/C15H15N3OS/c16-15(20)18-17-14(19)13-8-6-12(7-9-13)10-11-4-2-1-3-5-11/h1-9H,10H2,(H,17,19)(H3,16,18,20) WEFAQZAUONPQTG-UHFFFAOYSA-N 50484535 CHEMBL1935523 Metallo-beta-lactamase type 2 18000 ChEMBL 10.1016/j.bmcl.2011.10.116 10.7270/Q2D79F7P 22115595 Faridoon, na; Hussein, WM; Vella, P; Islam, NU; Ollis, DL; Schenk, G; McGeary, RP The University of Queensland http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50484535 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50484535&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 57402245 433951800 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 51178735 NC(=S)NNC(=O)c1ccc(cc1)C(=O)c1ccc(cc1)[N+]([O-])=O InChI=1S/C15H12N4O4S/c16-15(24)18-17-14(21)11-3-1-9(2-4-11)13(20)10-5-7-12(8-6-10)19(22)23/h1-8H,(H,17,21)(H3,16,18,24) LCPUFTWEPUPZKD-UHFFFAOYSA-N 50484536 CHEMBL1935525 Metallo-beta-lactamase type 2 11000 ChEMBL 10.1016/j.bmcl.2011.10.116 10.7270/Q2D79F7P 22115595 Faridoon, na; Hussein, WM; Vella, P; Islam, NU; Ollis, DL; Schenk, G; McGeary, RP The University of Queensland http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50484536 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50484536&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 57398765 433951801 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 51187594 CC(C)CC(=O)N[C@H](C)C(=O)S[C@@H](C)Cc1ccc(cc1)-c1ccccc1 InChI=1S/C23H29NO2S/c1-16(2)14-22(25)24-18(4)23(26)27-17(3)15-19-10-12-21(13-11-19)20-8-6-5-7-9-20/h5-13,16-18H,14-15H2,1-4H3,(H,24,25)/t17-,18+/m0/s1 SYDZFZRBGMZVLN-ZWKOTPCHSA-N 50488254 CHEMBL2283127 Metallo-beta-lactamase type 2 5297 ChEMBL 10.1007/s00044-012-0172-1 10.7270/Q2RB77H5 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50488254 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50488254&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 76327237 433955519 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 51187595 OC(=O)[C@@H](Cc1ccccc1)[C@H](Cc1ccc2OCOc2c1)C(O)=O InChI=1S/C19H18O6/c20-18(21)14(8-12-4-2-1-3-5-12)15(19(22)23)9-13-6-7-16-17(10-13)25-11-24-16/h1-7,10,14-15H,8-9,11H2,(H,20,21)(H,22,23)/t14-,15-/m0/s1 ASEJDWRSZYAIOT-GJZGRUSLSA-N 50488255 CHEMBL1231535 Metallo-beta-lactamase type 2 3.7 ChEMBL 10.1007/s00044-012-0172-1 10.7270/Q2RB77H5 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50488255 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50488255&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search BYS 1JJE 5496627 433955520 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 51187596 OC(=O)[C@@H](S)Cc1ccc2oc3ccccc3c2c1 InChI=1S/C15H12O3S/c16-15(17)14(19)8-9-5-6-13-11(7-9)10-3-1-2-4-12(10)18-13/h1-7,14,19H,8H2,(H,16,17)/t14-/m0/s1 DGAQYMLDVCDTHC-AWEZNQCLSA-N 50488256 CHEMBL87757 Metallo-beta-lactamase type 2 250 ChEMBL 10.1007/s00044-012-0172-1 10.7270/Q2RB77H5 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50488256 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50488256&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 9878617 433955521 C01525 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 51187597 C[C@@H](Cc1ccc(cc1)-c1ccccc1)SC(=O)[C@@H](C)NC(=O)Cc1cccc2ccccc12 InChI=1S/C30H29NO2S/c1-21(19-23-15-17-25(18-16-23)24-9-4-3-5-10-24)34-30(33)22(2)31-29(32)20-27-13-8-12-26-11-6-7-14-28(26)27/h3-18,21-22H,19-20H2,1-2H3,(H,31,32)/t21-,22+/m0/s1 NVFCZXWUQRLCBZ-FCHUYYIVSA-N 50488257 CHEMBL2283141 Metallo-beta-lactamase type 2 11995 ChEMBL 10.1007/s00044-012-0172-1 10.7270/Q2RB77H5 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50488257 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50488257&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 76309081 433955522 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 51187598 OC(=O)[C@@H](Cc1ccc2oc3ccccc3c2c1)SC(=O)c1ccccc1 InChI=1S/C22H16O4S/c23-21(24)20(27-22(25)15-6-2-1-3-7-15)13-14-10-11-19-17(12-14)16-8-4-5-9-18(16)26-19/h1-12,20H,13H2,(H,23,24)/t20-/m1/s1 KKKSWXOXMOHROK-HXUWFJFHSA-N 50081025 (R)-2-Benzoylsulfanyl-3-dibenzofuran-2-yl-propionic acid::CHEMBL419293 Metallo-beta-lactamase type 2 1.3 ChEMBL 10.1007/s00044-012-0172-1 10.7270/Q2RB77H5 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50081025 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50081025&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 10110056 103981118 CHEMBL419293 ZINC03994819 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 51187599 C[C@@H](Cc1ccc(cc1)-c1ccccc1)SC(=O)[C@@H](C)NC(=O)CCCC(O)=O InChI=1S/C23H27NO4S/c1-16(29-23(28)17(2)24-21(25)9-6-10-22(26)27)15-18-11-13-20(14-12-18)19-7-4-3-5-8-19/h3-5,7-8,11-14,16-17H,6,9-10,15H2,1-2H3,(H,24,25)(H,26,27)/t16-,17+/m0/s1 SFKWXWUCAQJVPW-DLBZAZTESA-N 50488258 CHEMBL2283015 Metallo-beta-lactamase type 2 90991 ChEMBL 10.1007/s00044-012-0172-1 10.7270/Q2RB77H5 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50488258 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50488258&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 76316289 433955523 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 51187600 C[C@@H](Cc1ccc2oc3ccccc3c2c1)SC(=O)[C@@H](C)NC(C)=O InChI=1S/C20H21NO3S/c1-12(25-20(23)13(2)21-14(3)22)10-15-8-9-19-17(11-15)16-6-4-5-7-18(16)24-19/h4-9,11-13H,10H2,1-3H3,(H,21,22)/t12-,13+/m0/s1 DTYWJLNEGCUSTN-QWHCGFSZSA-N 50488259 CHEMBL2283147 Metallo-beta-lactamase type 2 2000 ChEMBL 10.1007/s00044-012-0172-1 10.7270/Q2RB77H5 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50488259 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50488259&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 76330896 433955524 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 51187601 C\C=C\C(=O)N[C@H](C)C(=O)S[C@@H](C)Cc1ccc(cc1)-c1ccccc1 InChI=1S/C22H25NO2S/c1-4-8-21(24)23-17(3)22(25)26-16(2)15-18-11-13-20(14-12-18)19-9-6-5-7-10-19/h4-14,16-17H,15H2,1-3H3,(H,23,24)/b8-4+/t16-,17+/m0/s1 RHQVCFARGBSYOC-ACISRZNPSA-N 50488260 CHEMBL2283128 Metallo-beta-lactamase type 2 32961 ChEMBL 10.1007/s00044-012-0172-1 10.7270/Q2RB77H5 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50488260 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50488260&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 76330893 433955525 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 51187602 C[C@@H](Cc1ccc(cc1)-c1ccccc1)SC(=O)[C@@H](C)NC(=O)Cc1cccnc1 InChI=1S/C25H26N2O2S/c1-18(15-20-10-12-23(13-11-20)22-8-4-3-5-9-22)30-25(29)19(2)27-24(28)16-21-7-6-14-26-17-21/h3-14,17-19H,15-16H2,1-2H3,(H,27,28)/t18-,19+/m0/s1 BQGWFOPNVBDRHK-RBUKOAKNSA-N 50488261 CHEMBL2283140 Metallo-beta-lactamase type 2 31989 ChEMBL 10.1007/s00044-012-0172-1 10.7270/Q2RB77H5 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50488261 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50488261&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 76323662 433955526 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 51187603 OC(=O)[C@H](Cc1ccccc1)SC(=O)c1ccccc1 InChI=1S/C16H14O3S/c17-15(18)14(11-12-7-3-1-4-8-12)20-16(19)13-9-5-2-6-10-13/h1-10,14H,11H2,(H,17,18)/t14-/m0/s1 HEDPYMVCQLZHHF-AWEZNQCLSA-N 50488262 CHEMBL87857 Metallo-beta-lactamase type 2 2500 ChEMBL 10.1007/s00044-012-0172-1 10.7270/Q2RB77H5 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50488262 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50488262&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 9878985 433955527 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 51187604 CCC(=O)N[C@H](C)C(=O)S[C@@H](C)Cc1ccc(cc1)-c1ccccc1 InChI=1S/C21H25NO2S/c1-4-20(23)22-16(3)21(24)25-15(2)14-17-10-12-19(13-11-17)18-8-6-5-7-9-18/h5-13,15-16H,4,14H2,1-3H3,(H,22,23)/t15-,16+/m0/s1 QDVOCQWROGVRNS-JKSUJKDBSA-N 50488263 CHEMBL2283013 Metallo-beta-lactamase type 2 9506 ChEMBL 10.1007/s00044-012-0172-1 10.7270/Q2RB77H5 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50488263 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50488263&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 76312751 433955528 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 51187605 OC(=O)[C@@H](Cc1ccc2OCOc2c1)[C@H](Cc1ccc2OCOc2c1)C(O)=O InChI=1S/C20H18O8/c21-19(22)13(5-11-1-3-15-17(7-11)27-9-25-15)14(20(23)24)6-12-2-4-16-18(8-12)28-10-26-16/h1-4,7-8,13-14H,5-6,9-10H2,(H,21,22)(H,23,24)/t13-,14-/m0/s1 FFYBYVPVYLMLAR-KBPBESRZSA-N 50488264 CHEMBL1231277 Metallo-beta-lactamase type 2 9.0 ChEMBL 10.1007/s00044-012-0172-1 10.7270/Q2RB77H5 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50488264 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50488264&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search BDS 1JJT 5496628 433955529 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 51187606 C[C@@H](Cc1ccc2oc3ccccc3c2c1)SC(=O)[C@@H](C)NC(=O)OCC=C InChI=1S/C22H23NO4S/c1-4-11-26-22(25)23-15(3)21(24)28-14(2)12-16-9-10-20-18(13-16)17-7-5-6-8-19(17)27-20/h4-10,13-15H,1,11-12H2,2-3H3,(H,23,25)/t14-,15+/m0/s1 LCZSJJBVYIFGSJ-LSDHHAIUSA-N 50488265 CHEMBL2283011 Metallo-beta-lactamase type 2 2897 ChEMBL 10.1007/s00044-012-0172-1 10.7270/Q2RB77H5 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50488265 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50488265&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 76323635 433955530 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 51187607 C[C@@H](Cc1ccc(cc1)-c1ccccc1)SC(=O)[C@@H](C)NC(C)=O InChI=1S/C20H23NO2S/c1-14(24-20(23)15(2)21-16(3)22)13-17-9-11-19(12-10-17)18-7-5-4-6-8-18/h4-12,14-15H,13H2,1-3H3,(H,21,22)/t14-,15+/m0/s1 XOLFQHMHJUCOAL-LSDHHAIUSA-N 50488266 CHEMBL2283121 Metallo-beta-lactamase type 2 17989 ChEMBL 10.1007/s00044-012-0172-1 10.7270/Q2RB77H5 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50488266 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50488266&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 76319991 433955531 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 51187608 CCCCCC(=O)N[C@H](C)C(=O)S[C@@H](C)Cc1ccc(cc1)-c1ccccc1 InChI=1S/C24H31NO2S/c1-4-5-7-12-23(26)25-19(3)24(27)28-18(2)17-20-13-15-22(16-14-20)21-10-8-6-9-11-21/h6,8-11,13-16,18-19H,4-5,7,12,17H2,1-3H3,(H,25,26)/t18-,19+/m0/s1 AUOSVICBDVUPQK-RBUKOAKNSA-N 50488267 CHEMBL2283125 Metallo-beta-lactamase type 2 13002 ChEMBL 10.1007/s00044-012-0172-1 10.7270/Q2RB77H5 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50488267 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50488267&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 76327236 433955532 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 51187609 C[C@@H](Cc1ccc(cc1)-c1ccccc1)SC(=O)[C@@H](C)NC(=O)Cc1ccccc1 InChI=1S/C26H27NO2S/c1-19(17-22-13-15-24(16-14-22)23-11-7-4-8-12-23)30-26(29)20(2)27-25(28)18-21-9-5-3-6-10-21/h3-16,19-20H,17-18H2,1-2H3,(H,27,28)/t19-,20+/m0/s1 HUDZJMOHGMGFNH-VQTJNVASSA-N 50488268 CHEMBL2283130 Metallo-beta-lactamase type 2 5794 ChEMBL 10.1007/s00044-012-0172-1 10.7270/Q2RB77H5 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50488268 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50488268&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 76323660 433955533 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 51187610 C[C@@H](Cc1ccc(cc1)-c1ccccc1)SC(=O)[C@@H](C)NC(=O)CCC(=O)c1ccccc1 InChI=1S/C28H29NO3S/c1-20(19-22-13-15-24(16-14-22)23-9-5-3-6-10-23)33-28(32)21(2)29-27(31)18-17-26(30)25-11-7-4-8-12-25/h3-16,20-21H,17-19H2,1-2H3,(H,29,31)/t20-,21+/m0/s1 FUWPWXJBAXLAPV-LEWJYISDSA-N 50488269 CHEMBL2283134 Metallo-beta-lactamase type 2 250 ChEMBL 10.1007/s00044-012-0172-1 10.7270/Q2RB77H5 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50488269 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50488269&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 76323661 433955534 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 51187611 C[C@@H](Cc1ccc(cc1)-c1ccccc1)SC(=O)[C@@H](C)NC(=O)Cc1ccccc1Cc1ccccc1 InChI=1S/C33H33NO2S/c1-24(21-27-17-19-29(20-18-27)28-13-7-4-8-14-28)37-33(36)25(2)34-32(35)23-31-16-10-9-15-30(31)22-26-11-5-3-6-12-26/h3-20,24-25H,21-23H2,1-2H3,(H,34,35)/t24-,25+/m0/s1 KLZZELLPWBRZDH-LOSJGSFVSA-N 50488270 CHEMBL2283139 Metallo-beta-lactamase type 2 23988 ChEMBL 10.1007/s00044-012-0172-1 10.7270/Q2RB77H5 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50488270 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50488270&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 76330895 433955535 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 51187612 OC(=O)C(NC(=O)C(CS)CCc1ccccc1)c1ccc(CN2NNN=C2)s1 InChI=1S/C19H23N5O3S2/c25-18(14(11-28)7-6-13-4-2-1-3-5-13)21-17(19(26)27)16-9-8-15(29-16)10-24-12-20-22-23-24/h1-5,8-9,12,14,17,22-23,28H,6-7,10-11H2,(H,21,25)(H,26,27) QAICUIUPXSIRFG-UHFFFAOYSA-N 50488271 CHEMBL2283146 Metallo-beta-lactamase type 2 90 ChEMBL 10.1007/s00044-012-0172-1 10.7270/Q2RB77H5 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50488271 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50488271&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 76327238 433955536 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 51187613 CCCC(=O)N[C@H](C)C(=O)S[C@@H](C)Cc1ccc(cc1)-c1ccccc1 InChI=1S/C22H27NO2S/c1-4-8-21(24)23-17(3)22(25)26-16(2)15-18-11-13-20(14-12-18)19-9-6-5-7-10-19/h5-7,9-14,16-17H,4,8,15H2,1-3H3,(H,23,24)/t16-,17+/m0/s1 FTLQLFZUJQTFHE-DLBZAZTESA-N 50488272 CHEMBL2283012 Metallo-beta-lactamase type 2 9290 ChEMBL 10.1007/s00044-012-0172-1 10.7270/Q2RB77H5 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50488272 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50488272&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 76323636 433955537 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 51187614 C[C@@H](Cc1ccc2oc3ccccc3c2c1)SC(=O)[C@@H](C)NC(=O)c1ccccc1 InChI=1S/C25H23NO3S/c1-16(30-25(28)17(2)26-24(27)19-8-4-3-5-9-19)14-18-12-13-23-21(15-18)20-10-6-7-11-22(20)29-23/h3-13,15-17H,14H2,1-2H3,(H,26,27)/t16-,17+/m0/s1 PKMJZKFQLQMKMU-DLBZAZTESA-N 50488273 CHEMBL2283014 Metallo-beta-lactamase type 2 1500 ChEMBL 10.1007/s00044-012-0172-1 10.7270/Q2RB77H5 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50488273 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50488273&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 76330876 433955538 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 51187615 C[C@@H](Cc1ccccc1)SC(=O)[C@@H](C)NC(=O)c1ccccc1 InChI=1S/C19H21NO2S/c1-14(13-16-9-5-3-6-10-16)23-19(22)15(2)20-18(21)17-11-7-4-8-12-17/h3-12,14-15H,13H2,1-2H3,(H,20,21)/t14-,15+/m0/s1 CXUIURVJZGYBRQ-LSDHHAIUSA-N 50488274 CHEMBL2283016 Metallo-beta-lactamase type 2 19999 ChEMBL 10.1007/s00044-012-0172-1 10.7270/Q2RB77H5 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50488274 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50488274&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 76319979 433955539 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 51187616 C[C@@H](Cc1ccc(cc1)-c1ccccc1)SC(=O)[C@@H](C)NC(=O)OCC=C InChI=1S/C22H25NO3S/c1-4-14-26-22(25)23-17(3)21(24)27-16(2)15-18-10-12-20(13-11-18)19-8-6-5-7-9-19/h4-13,16-17H,1,14-15H2,2-3H3,(H,23,25)/t16-,17+/m0/s1 CJPFXBKALUWKID-DLBZAZTESA-N 50488275 CHEMBL2283122 Metallo-beta-lactamase type 2 4395 ChEMBL 10.1007/s00044-012-0172-1 10.7270/Q2RB77H5 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50488275 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50488275&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 76327235 433955540 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 51187617 C[C@@H](Cc1ccc(cc1)-c1ccccc1)SC(=O)[C@@H](C)NC(=O)c1ccccc1 InChI=1S/C25H25NO2S/c1-18(17-20-13-15-22(16-14-20)21-9-5-3-6-10-21)29-25(28)19(2)26-24(27)23-11-7-4-8-12-23/h3-16,18-19H,17H2,1-2H3,(H,26,27)/t18-,19+/m0/s1 DELXEIDVTIWZPJ-RBUKOAKNSA-N 50488276 CHEMBL2283123 Metallo-beta-lactamase type 2 3597 ChEMBL 10.1007/s00044-012-0172-1 10.7270/Q2RB77H5 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50488276 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50488276&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 76334474 433955541 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 51187618 C[C@@H](Cc1ccc(cc1)-c1ccccc1)SC(=O)[C@@H](C)NC(=O)C(C)C InChI=1S/C22H27NO2S/c1-15(2)21(24)23-17(4)22(25)26-16(3)14-18-10-12-20(13-11-18)19-8-6-5-7-9-19/h5-13,15-17H,14H2,1-4H3,(H,23,24)/t16-,17+/m0/s1 XOZNCLAMAQOEAU-DLBZAZTESA-N 50488277 CHEMBL2283126 Metallo-beta-lactamase type 2 9705 ChEMBL 10.1007/s00044-012-0172-1 10.7270/Q2RB77H5 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50488277 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50488277&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 76323659 433955542 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 51187619 C[C@@H](Cc1ccc(cc1)-c1ccccc1)SC(=O)[C@@H](C)NC(=O)CSCC(O)=O InChI=1S/C22H25NO4S2/c1-15(29-22(27)16(2)23-20(24)13-28-14-21(25)26)12-17-8-10-19(11-9-17)18-6-4-3-5-7-18/h3-11,15-16H,12-14H2,1-2H3,(H,23,24)(H,25,26)/t15-,16+/m0/s1 OUXKIRZTPKYOEG-JKSUJKDBSA-N 50488278 CHEMBL2283129 Metallo-beta-lactamase type 2 13002 ChEMBL 10.1007/s00044-012-0172-1 10.7270/Q2RB77H5 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50488278 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50488278&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 76319993 433955543 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 51187620 C[C@@H](Cc1ccc(cc1)-c1ccccc1)SC(=O)[C@@H](C)NC(=O)COc1ccccc1 InChI=1S/C26H27NO3S/c1-19(17-21-13-15-23(16-14-21)22-9-5-3-6-10-22)31-26(29)20(2)27-25(28)18-30-24-11-7-4-8-12-24/h3-16,19-20H,17-18H2,1-2H3,(H,27,28)/t19-,20+/m0/s1 ZZMWBAVTHGCHGO-VQTJNVASSA-N 50488279 CHEMBL2283131 Metallo-beta-lactamase type 2 1000 ChEMBL 10.1007/s00044-012-0172-1 10.7270/Q2RB77H5 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50488279 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50488279&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 76319994 433955544 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 51187621 C[C@@H](Cc1ccc(cc1)-c1ccccc1)SC(=O)[C@@H](C)NC(=O)CCc1ccccc1 InChI=1S/C27H29NO2S/c1-20(19-23-13-16-25(17-14-23)24-11-7-4-8-12-24)31-27(30)21(2)28-26(29)18-15-22-9-5-3-6-10-22/h3-14,16-17,20-21H,15,18-19H2,1-2H3,(H,28,29)/t20-,21+/m0/s1 QFJZOXQFSBIOHM-LEWJYISDSA-N 50488280 CHEMBL2283132 Metallo-beta-lactamase type 2 14997 ChEMBL 10.1007/s00044-012-0172-1 10.7270/Q2RB77H5 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50488280 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50488280&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 76334475 433955545 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 51187622 C[C@@H](Cc1ccc(cc1)-c1ccccc1)SC(=O)[C@@H](C)NC(=O)CNC(=O)c1ccccc1 InChI=1S/C27H28N2O3S/c1-19(17-21-13-15-23(16-14-21)22-9-5-3-6-10-22)33-27(32)20(2)29-25(30)18-28-26(31)24-11-7-4-8-12-24/h3-16,19-20H,17-18H2,1-2H3,(H,28,31)(H,29,30)/t19-,20+/m0/s1 ARJPYECHSRSYJH-VQTJNVASSA-N 50488281 CHEMBL2283135 Metallo-beta-lactamase type 2 50003 ChEMBL 10.1007/s00044-012-0172-1 10.7270/Q2RB77H5 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50488281 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50488281&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 76330894 433955546 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 51187623 COc1ccc(CC(=O)N[C@H](C)C(=O)S[C@@H](C)Cc2ccc(cc2)-c2ccccc2)cc1 InChI=1S/C27H29NO3S/c1-19(17-21-9-13-24(14-10-21)23-7-5-4-6-8-23)32-27(30)20(2)28-26(29)18-22-11-15-25(31-3)16-12-22/h4-16,19-20H,17-18H2,1-3H3,(H,28,29)/t19-,20+/m0/s1 RETWBVWWPPYYNL-VQTJNVASSA-N 50488282 CHEMBL2283137 Metallo-beta-lactamase type 2 11995 ChEMBL 10.1007/s00044-012-0172-1 10.7270/Q2RB77H5 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50488282 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50488282&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 76316302 433955547 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 51187624 C[C@@H](Cc1ccc(cc1)-c1ccccc1)SC(=O)[C@@H](C)NC(=O)Cc1ccc(cc1)N(C)C InChI=1S/C28H32N2O2S/c1-20(18-22-10-14-25(15-11-22)24-8-6-5-7-9-24)33-28(32)21(2)29-27(31)19-23-12-16-26(17-13-23)30(3)4/h5-17,20-21H,18-19H2,1-4H3,(H,29,31)/t20-,21+/m0/s1 PCGVIBYXGISXAP-LEWJYISDSA-N 50488283 CHEMBL2283138 Metallo-beta-lactamase type 2 54954 ChEMBL 10.1007/s00044-012-0172-1 10.7270/Q2RB77H5 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50488283 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50488283&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 76319996 433955548 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 51187625 C[C@@H](Cc1ccc(cc1)-c1ccccc1)SC(=O)[C@@H](C)NC(=O)Cc1ccc(O)cc1 InChI=1S/C26H27NO3S/c1-18(16-20-8-12-23(13-9-20)22-6-4-3-5-7-22)31-26(30)19(2)27-25(29)17-21-10-14-24(28)15-11-21/h3-15,18-19,28H,16-17H2,1-2H3,(H,27,29)/t18-,19+/m0/s1 IQELJUMGERCCQE-RBUKOAKNSA-N 50488284 CHEMBL2283136 Metallo-beta-lactamase type 2 3097 ChEMBL 10.1007/s00044-012-0172-1 10.7270/Q2RB77H5 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50488284 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50488284&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 76316301 433955549 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 51187626 OC(=O)[C@H](Cc1ccccc1)[C@@H](Cc1ccccc1)C(O)=O InChI=1S/C18H18O4/c19-17(20)15(11-13-7-3-1-4-8-13)16(18(21)22)12-14-9-5-2-6-10-14/h1-10,15-16H,11-12H2,(H,19,20)(H,21,22)/t15-,16-/m1/s1 UUTKSMWBUAJELT-HZPDHXFCSA-N 50488285 (2R,3R)-2,3-DIBENZYLSUCCINIC ACID Metallo-beta-lactamase type 2 210 ChEMBL 10.1007/s00044-012-0172-1 10.7270/Q2RB77H5 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50488285 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50488285&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 10266691 433955550 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 51187627 C[C@H]([C@@H]([C@H](Cc1ccccc1)C(O)=O)C(O)=O)c1ccccc1 InChI=1S/C19H20O4/c1-13(15-10-6-3-7-11-15)17(19(22)23)16(18(20)21)12-14-8-4-2-5-9-14/h2-11,13,16-17H,12H2,1H3,(H,20,21)(H,22,23)/t13-,16-,17-/m0/s1 JRXQSNURQGZWPD-JQFCIGGWSA-N 50488286 CHEMBL2283145 Metallo-beta-lactamase type 2 13 ChEMBL 10.1007/s00044-012-0172-1 10.7270/Q2RB77H5 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50488286 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50488286&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 76312768 433955551 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 51187628 COc1ccc(cc1)C(=O)N[C@H](C)C(=O)S[C@@H](C)Cc1ccc(cc1)-c1ccccc1 InChI=1S/C26H27NO3S/c1-18(17-20-9-11-22(12-10-20)21-7-5-4-6-8-21)31-26(29)19(2)27-25(28)23-13-15-24(30-3)16-14-23/h4-16,18-19H,17H2,1-3H3,(H,27,28)/t18-,19+/m0/s1 ZJOZIEKBMMZHIJ-RBUKOAKNSA-N 50488287 CHEMBL2283142 Metallo-beta-lactamase type 2 28973 ChEMBL 10.1007/s00044-012-0172-1 10.7270/Q2RB77H5 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50488287 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50488287&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 76319997 433955552 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 51187629 C[C@@H](Cc1ccc(cc1)-c1ccccc1)SC(=O)[C@@H](C)NC(=O)c1ccc2ccccc2c1 InChI=1S/C29H27NO2S/c1-20(18-22-12-14-25(15-13-22)23-8-4-3-5-9-23)33-29(32)21(2)30-28(31)27-17-16-24-10-6-7-11-26(24)19-27/h3-17,19-21H,18H2,1-2H3,(H,30,31)/t20-,21+/m0/s1 IPHHXOATUSFRQT-LEWJYISDSA-N 50488288 CHEMBL2283010 Metallo-beta-lactamase type 2 17989 ChEMBL 10.1007/s00044-012-0172-1 10.7270/Q2RB77H5 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50488288 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50488288&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 76309073 433955553 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 51187630 CC(=O)S[C@H](Cc1ccccc1)C(O)=O InChI=1S/C11H12O3S/c1-8(12)15-10(11(13)14)7-9-5-3-2-4-6-9/h2-6,10H,7H2,1H3,(H,13,14)/t10-/m1/s1 UOVSNFYJYANSNI-SNVBAGLBSA-N 50081017 (R)-2-Acetylsulfanyl-3-phenyl-propionic acid::CHEMBL87421 Metallo-beta-lactamase type 2 11995 ChEMBL 10.1007/s00044-012-0172-1 10.7270/Q2RB77H5 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50081017 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50081017&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 9813292 103981114 CHEMBL87421 C04334 ZINC00026598 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 51187631 OC(=O)[C@@H](Cc1ccccc1)SC(=O)c1ccccc1 InChI=1S/C16H14O3S/c17-15(18)14(11-12-7-3-1-4-8-12)20-16(19)13-9-5-2-6-10-13/h1-10,14H,11H2,(H,17,18)/t14-/m1/s1 HEDPYMVCQLZHHF-CQSZACIVSA-N 50081057 (R)-2-Benzoylsulfanyl-3-phenyl-propionic acid::CHEMBL315343 Metallo-beta-lactamase type 2 64 ChEMBL 10.1007/s00044-012-0172-1 10.7270/Q2RB77H5 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50081057 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50081057&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 9943761 103981134 CHEMBL315343 ZINC00026597 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 51187632 OC(=O)[C@H](S)Cc1ccccc1 InChI=1S/C9H10O2S/c10-9(11)8(12)6-7-4-2-1-3-5-7/h1-5,8,12H,6H2,(H,10,11)/t8-/m1/s1 HGIOOMCLOWLFTJ-MRVPVSSYSA-N 50081016 (R)-2-Mercapto-3-phenyl-propionic acid::CHEMBL87685 Metallo-beta-lactamase type 2 86 ChEMBL 10.1007/s00044-012-0172-1 10.7270/Q2RB77H5 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50081016 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50081016&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 13662428 103981113 CHEMBL87685 C01525 ZINC03873622 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 51187633 OC(=O)[C@H](S)Cc1ccc2oc3ccccc3c2c1 InChI=1S/C15H12O3S/c16-15(17)14(19)8-9-5-6-13-11(7-9)10-3-1-2-4-12(10)18-13/h1-7,14,19H,8H2,(H,16,17)/t14-/m1/s1 DGAQYMLDVCDTHC-CQSZACIVSA-N 50081042 (R)-3-Dibenzofuran-2-yl-2-mercapto-propionic acid::CHEMBL87686 Metallo-beta-lactamase type 2 23 ChEMBL 10.1007/s00044-012-0172-1 10.7270/Q2RB77H5 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50081042 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50081042&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 9816938 103981127 CHEMBL87686 C01525 ZINC26574265 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 51187634 OC(=O)[C@@H](S)Cc1ccc(cc1)-c1ccccc1 InChI=1S/C15H14O2S/c16-15(17)14(18)10-11-6-8-13(9-7-11)12-4-2-1-3-5-12/h1-9,14,18H,10H2,(H,16,17)/t14-/m0/s1 CPBIZOLNPHDUOX-AWEZNQCLSA-N 50488289 CHEMBL88072 Metallo-beta-lactamase type 2 1199 ChEMBL 10.1007/s00044-012-0172-1 10.7270/Q2RB77H5 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50488289 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50488289&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 9834939 433955554 C01525 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 51187635 OC(=O)[C@@H](Cc1ccccc1)[C@H](Cc1ccccc1)C(O)=O InChI=1S/C18H18O4/c19-17(20)15(11-13-7-3-1-4-8-13)16(18(21)22)12-14-9-5-2-6-10-14/h1-10,15-16H,11-12H2,(H,19,20)(H,21,22)/t15-,16-/m0/s1 UUTKSMWBUAJELT-HOTGVXAUSA-N 50488290 CHEMBL2283143 Metallo-beta-lactamase type 2 2.7 ChEMBL 10.1007/s00044-012-0172-1 10.7270/Q2RB77H5 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50488290 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50488290&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 59100334 433955555 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 51187636 C[C@@H](Cc1ccc(cc1)-c1ccccc1)SC(=O)[C@@H](C)NC(=O)c1cccc(c1)N(C)C InChI=1S/C27H30N2O2S/c1-19(17-21-13-15-23(16-14-21)22-9-6-5-7-10-22)32-27(31)20(2)28-26(30)24-11-8-12-25(18-24)29(3)4/h5-16,18-20H,17H2,1-4H3,(H,28,30)/t19-,20+/m0/s1 SJLQGHGCUHMOES-VQTJNVASSA-N 50488291 CHEMBL2283008 Metallo-beta-lactamase type 2 14997 ChEMBL 10.1007/s00044-012-0172-1 10.7270/Q2RB77H5 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50488291 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50488291&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 76323634 433955556 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 51187637 CC(=O)S[C@H](Cc1ccc(cc1)-c1ccccc1)C(O)=O InChI=1S/C17H16O3S/c1-12(18)21-16(17(19)20)11-13-7-9-15(10-8-13)14-5-3-2-4-6-14/h2-10,16H,11H2,1H3,(H,19,20)/t16-/m1/s1 DOIIMJAAMADLSI-MRXNPFEDSA-N 50081044 (R)-2-Acetylsulfanyl-3-biphenyl-4-yl-propionic acid::CHEMBL315179 Metallo-beta-lactamase type 2 84 ChEMBL 10.1007/s00044-012-0172-1 10.7270/Q2RB77H5 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50081044 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50081044&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 9948275 103981128 CHEMBL315179 C04334 ZINC00026599 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 51187638 OC(=O)[C@H](S)Cc1ccc(cc1)-c1ccccc1 InChI=1S/C15H14O2S/c16-15(17)14(18)10-11-6-8-13(9-7-11)12-4-2-1-3-5-12/h1-9,14,18H,10H2,(H,16,17)/t14-/m1/s1 CPBIZOLNPHDUOX-CQSZACIVSA-N 50081056 (R)-3-Biphenyl-4-yl-2-mercapto-propionic acid::CHEMBL314563 Metallo-beta-lactamase type 2 57 ChEMBL 10.1007/s00044-012-0172-1 10.7270/Q2RB77H5 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50081056 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50081056&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 9816592 103981133 CHEMBL314563 C01525 ZINC26574263 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 51187639 COc1cccc(c1)C(=O)N[C@H](C)C(=O)S[C@@H](C)Cc1ccc(cc1)-c1ccccc1 InChI=1S/C26H27NO3S/c1-18(16-20-12-14-22(15-13-20)21-8-5-4-6-9-21)31-26(29)19(2)27-25(28)23-10-7-11-24(17-23)30-3/h4-15,17-19H,16H2,1-3H3,(H,27,28)/t18-,19+/m0/s1 JPYFWNLNTYROGX-RBUKOAKNSA-N 50488292 CHEMBL2283007 Metallo-beta-lactamase type 2 38019 ChEMBL 10.1007/s00044-012-0172-1 10.7270/Q2RB77H5 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50488292 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50488292&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 76327217 433955557 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 51187640 CCCCC(=O)N[C@H](C)C(=O)S[C@@H](C)Cc1ccc(cc1)-c1ccccc1 InChI=1S/C23H29NO2S/c1-4-5-11-22(25)24-18(3)23(26)27-17(2)16-19-12-14-21(15-13-19)20-9-7-6-8-10-20/h6-10,12-15,17-18H,4-5,11,16H2,1-3H3,(H,24,25)/t17-,18+/m0/s1 RUMJEUFEXYMHMN-ZWKOTPCHSA-N 50488293 CHEMBL2283124 Metallo-beta-lactamase type 2 4797 ChEMBL 10.1007/s00044-012-0172-1 10.7270/Q2RB77H5 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50488293 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50488293&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 76319992 433955558 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 51187641 COc1cc(OC)c(C(=O)N[C@H](C)C(=O)S[C@@H](C)Cc2ccc(cc2)-c2ccccc2)c(OC)c1 InChI=1S/C28H31NO5S/c1-18(15-20-11-13-22(14-12-20)21-9-7-6-8-10-21)35-28(31)19(2)29-27(30)26-24(33-4)16-23(32-3)17-25(26)34-5/h6-14,16-19H,15H2,1-5H3,(H,29,30)/t18-,19+/m0/s1 PYBHQQQGIUSSKV-RBUKOAKNSA-N 50488294 CHEMBL2283009 Metallo-beta-lactamase type 2 46026 ChEMBL 10.1007/s00044-012-0172-1 10.7270/Q2RB77H5 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50488294 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50488294&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 76327218 433955559 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 51187642 C[C@@H](Cc1ccc(cc1)-c1ccccc1)SC(=O)[C@@H](C)NC(=O)\C=C\c1ccccc1 InChI=1S/C27H27NO2S/c1-20(19-23-13-16-25(17-14-23)24-11-7-4-8-12-24)31-27(30)21(2)28-26(29)18-15-22-9-5-3-6-10-22/h3-18,20-21H,19H2,1-2H3,(H,28,29)/b18-15+/t20-,21+/m0/s1 MGNXRLCWBSXQKG-ARDSCDRSSA-N 50488295 CHEMBL2283133 Metallo-beta-lactamase type 2 10990 ChEMBL 10.1007/s00044-012-0172-1 10.7270/Q2RB77H5 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50488295 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50488295&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 76319995 433955560 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863757 NS(=O)(=O)c1c(ccc(-c2cccc(Nc3ncc[nH]3)c2)c1-c1nn[nH]n1)S(=O)(=O)N[C@H]1CCNC1 361315 (R)-N1-(3- (aminomethyl)pyrrolidin-3-yl)- 4-(6-aminopyridin-3-yl)-3 - (2H-tetrazol-5-yl)benzene-1,2- disulfonamide dihydrochloride::US10221163, Example 472::US10544130, Example 472 Metallo-beta-lactamase type 2 0.847 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361315 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361315&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 137537743 386400703 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863760 NC[C@H](O)CNS(=O)(=O)c1ccc(-c2ccc3sc(CN)nc3c2)c(-c2nn[nH]n2)c1S(N)(=O)=O 361316 (S)-N1-(3-amino-2- hydroxypropyl)-4-(2- (aminomethyl)benzo[d]thiazol- 5-yl)-3-(2H-tetrazol-5- yl)benzene-1,2-disulfonamide::US10221163, Example 473::US10544130, Example 473 Metallo-beta-lactamase type 2 0.329 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361316 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361316&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311423 386400704 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863763 NC[C@@H](CO)NS(=O)(=O)c1ccc(-c2ccc3[nH]c(CN)nc3c2)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C18H20N10O5S2/c19-6-10(8-29)26-35(32,33)14-4-2-11(9-1-3-12-13(5-9)23-15(7-20)22-12)16(17(14)34(21,30)31)18-24-27-28-25-18/h1-5,10,26,29H,6-8,19-20H2,(H2,21,30,31)/b11-9+/t10-/m0/s1 FBSOKGRQTNLARE-SPQRFVMMSA-N 361317 (S)-N1-(1-amino-3- hydroxypropan-2-yl)-4-(2- (aminomethyl)-1H-benzo[d] imidazol-5-yl)-3-(2H- tetrazol-5-yl)benzene-1,2- disulfonamide::US10221163, Example 474::US10544130, Example 474 Metallo-beta-lactamase type 2 0.522 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361317 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361317&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135310983 386400705 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863766 NC[C@@H](CO)NS(=O)(=O)c1ccc(-c2ccc3sc(CN)nc3c2)c(-c2nn[nH]n2)c1S(N)(=O)=O 361318 (S)-N1-(1-amino-3- hydroxypropan-2-yl)-4-(2- (aminomethyl)benzo[d]thiazol- 5-yl)-3-(2H-tetrazol-5- yl)benzene-1,2-disulfonamide::US10221163, Example 475::US10544130, Example 475 Metallo-beta-lactamase type 2 0.130 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361318 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361318&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311834 386400706 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863769 NCCNS(=O)(=O)c1ccc(-c2ccc3sc(CN)nc3c2)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C17H19N9O4S3/c18-5-6-21-33(29,30)13-4-2-10(9-1-3-12-11(7-9)22-14(8-19)31-12)15(16(13)32(20,27)28)17-23-25-26-24-17/h1-4,7,21H,5-6,8,18-19H2,(H2,20,27,28)(H,23,24,25,26) OYHMXKMDUJOANP-UHFFFAOYSA-N 361319 N1-(2-aminoethyl)-4-(2- (aminomethyl)benzo[d]thiazol- 5-yl)-3-(2H-tetrazol-5- yl)benzene-1,2-disulfonamide::US10221163, Example 476::US10544130, Example 476 Metallo-beta-lactamase type 2 0.281 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361319 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361319&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311115 386400707 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863772 Cc1cc(cnc1N)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)NC[C@H](O)CN 361320 (R)—N1-(3-amino-2-hydroxypropyl)-4-(6-amino-5-methylpyridin-3-yl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 477::US10544130, Example 477 Metallo-beta-lactamase type 2 0.842 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361320 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361320&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311930 386400708 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863775 NC[C@@H](O)CNS(=O)(=O)c1ccc(-c2cnc(N)c(F)c2)c(-c2nn[nH]n2)c1S(N)(=O)=O 361321 (R)-N1-(3-amino-2- hydroxypropyl)-4-(6-amino-5- fluoropyridin-3-yl)-3-(2H- tetrazol-5-yl)benzene-1,2- disulfonamide::US10221163, Example 478::US10544130, Example 478 Metallo-beta-lactamase type 2 0.677 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361321 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361321&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311805 386400709 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863778 C[C@H](N)CNS(=O)(=O)c1ccc(-c2ccc(N)nc2)c(-c2nn[nH]n2)c1S(N)(=O)=O 361322 (S)—N1-(2-aminopropyl)-4-(6-aminopyridin-3-yl)-3-(2H-tetrazol-5-yl) benzene-1,2-disulfonamide::US10221163, Example 479::US10544130, Example 479 Metallo-beta-lactamase type 2 0.664 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361322 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361322&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124158361 386400710 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863781 C[C@@H](N)CNS(=O)(=O)c1ccc(-c2ccc(N)nc2)c(-c2nn[nH]n2)c1S(N)(=O)=O 361323 (R)—N1-(2-aminopropyl)-4-(6-aminopyridin-3-yl)-3-(2H-tetrazol-5-yl) benzene-1,2-disulfonamide::US10221163, Example 480::US10544130, Example 480 Metallo-beta-lactamase type 2 0.320 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361323 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361323&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311058 386400711 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863784 NS(=O)(=O)c1c(ccc(-c2cccc3[nH]cnc23)c1-c1nn[nH]n1)S(=O)(=O)NC[C@H]1CNCCN1 InChI=1S/C19H20N10O4S2/c20-34(30,31)18-15(35(32,33)25-9-11-8-21-6-7-22-11)5-4-12(16(18)19-26-28-29-27-19)13-2-1-3-14-17(13)24-10-23-14/h1-5,10-11,21-22,25H,6-9H2,(H2,20,30,31)/b13-12+/t11-/m1/s1 WHSKQSMNKQWZCL-GXZRWPEMSA-N 361324 (R)-4-(1H-benzo[d]imidazol-4- yl)-N1-(piperazin-2-ylmethyl)- 3-(1H-tetrazol-5-yl)benzene- 1,2-disulfonamide::US10221163, Example 481::US10544130, Example 481 Metallo-beta-lactamase type 2 0.251 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361324 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361324&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311045 386400712 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863787 NCCNCCNS(=O)(=O)c1ccc(-c2ccc(N)nc2)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C16H22N10O4S2/c17-5-6-20-7-8-22-32(29,30)12-3-2-11(10-1-4-13(18)21-9-10)14(15(12)31(19,27)28)16-23-25-26-24-16/h1-4,9,20,22H,5-8,17H2,(H2,18,21)(H2,19,27,28)(H,23,24,25,26) IRSQPGJWCQJGBA-UHFFFAOYSA-N 361325 N1-(2-(-2-amineoethylamino)ethyl)-4-(6-aminopyridin-3-yl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 482::US10544130, Example 482 Metallo-beta-lactamase type 2 1.14 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361325 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361325&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124158549 386400713 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863790 N[C@H]1CC(C1)NS(=O)(=O)c1ccc(-c2ccc(N)nc2)c(-c2nn[nH]n2)c1S(N)(=O)=O 361326 N1-((1R,3R)-3- aminocyclobutyl)-4-(6- aminopyridin-3-yl)-3-(2H- tetrazol-5-yl)benzene-1,2- disulfonamide::US10221163, Example 483::US10544130, Example 483 Metallo-beta-lactamase type 2 0.330 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361326 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361326&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311404 386400714 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863793 Nc1ccc(cn1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)NCC1CCNC1 361327 (S)-4-(6-aminopyridin-3- yl)-N1-(pyrrolidin-3- ylmethyl)-3-(2H-tetrazol- 5-yl)benzene-1,2- disulfonamide::US10221163, Example 484::US10544130, Example 484 Metallo-beta-lactamase type 2 0.248 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361327 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361327&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311095 386400715 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863796 Nc1ccc(cn1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)N1CCNCC1 InChI=1S/C16H19N9O4S2/c17-13-4-1-10(9-20-13)11-2-3-12(31(28,29)25-7-5-19-6-8-25)15(30(18,26)27)14(11)16-21-23-24-22-16/h1-4,9,19H,5-8H2,(H2,17,20)(H2,18,26,27)(H,21,22,23,24) KCGYMVKIHZQNLT-UHFFFAOYSA-N 361328 3-(6-aminopyridin-3-yl)- 6-(piperazin-1- ylsulfonyl)-2-(2H- tetrazol-5- yl)benzenesulfonamide::US10221163, Example 485::US10544130, Example 485 Metallo-beta-lactamase type 2 3.58 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361328 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361328&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311532 386400716 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863799 NC[C@@]1(CCNC1)NS(=O)(=O)c1ccc(-c2ccc(N)nc2)c(-c2nn[nH]n2)c1S(N)(=O)=O 427650 (R)-N1-(3- (aminomethyl)pyrrolidin- 3-yl)-4-(6-aminopyridin- 3-yl)-3-(2H-tetrazol-5- yl)benzene-1,2- disulfonamide dihydrochloride::US10544130, Example 486 Metallo-beta-lactamase type 2 0.422 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=427650 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=427650&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311154 434317415 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863802 NC[C@]1(CCNC1)NS(=O)(=O)c1ccc(-c2ccc(N)nc2)c(-c2nn[nH]n2)c1S(N)(=O)=O 361329 (R)-N1-(3- (aminomethyl)pyrrolidin- 3-yl)-4-(6-aminopyridin- 3-yl)-3-(2H-tetrazol-5- yl)benzene-1,2- disulfonamide dihydrochloride::US10221163, Example 486::US10221163, Example 487::US10544130, Example 487 Metallo-beta-lactamase type 2 0.803 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361329 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361329&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311895 386400717 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863805 Nc1ccc(cn1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)NC[C@@H]1CCCN1 361331 (S)-4-(6-aminopyridin-3- yl)-N1-(pyrrolidin-2- ylmethyl)-3-(2H-tetrazol- 5-yl)benzene-1,2- disulfonamide::US10221163, Example 488::US10544130, Example 488 Metallo-beta-lactamase type 2 0.355 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361331 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361331&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135310856 386400718 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863808 Nc1ccc(cn1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)NC[C@H]1CCCN1 361332 (R)-4-(6-aminopyridin-3- yl)-N1-(pyrrolidin-2- ylmethyl)-3-(2H-tetrazol- 5-yl)benzene-1,2- disulfonamide::US10221163, Example 489::US10544130, Example 489 Metallo-beta-lactamase type 2 0.566 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361332 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361332&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311625 386400719 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863811 Nc1ccc(cn1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)N[C@@H]1CCCNC1 361333 (R)-4-(6-aminopyridin-3- yl)-N1-(piperidin-3-yl)-3- (2H-tetrazol-5- yl)benzene-1,2- disulfonamide::US10221163, Example 490::US10544130, Example 490 Metallo-beta-lactamase type 2 0.176 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361333 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361333&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311042 386400720 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863814 Nc1ccc(cn1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)NC[C@@H]1CCNC1 361334 (R)-4-(6-aminopyridin-3- yl)-N1-(pyrrolidin-3- ylmethyl)-3-(2H-tetrazol- 5-yl)benzene-1,2- disulfonamide::US10221163, Example 491::US10544130, Example 491 Metallo-beta-lactamase type 2 0.271 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361334 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361334&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311092 386400721 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862782 Nc1nc2c(cccc2s1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)NC1CNC1 InChI=1S/C17H17N9O4S3/c18-17-21-14-10(2-1-3-11(14)31-17)9-4-5-12(33(29,30)24-8-6-20-7-8)15(32(19,27)28)13(9)16-22-25-26-23-16/h1-5,8,20,24H,6-7H2,(H2,18,21)(H2,19,27,28)(H,22,23,25,26) CADODRJOFDTRLR-UHFFFAOYSA-N 360990 4-(2-aminobenzo[d]thiazol-4- yl)-N1-(azetidin-3-yl)-3-(2H- tetrazol-5-yl)benzene-1,2- disulfonamide::US10221163, Example 146::US10544130, Example 146 Metallo-beta-lactamase type 2 0.356 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360990 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360990&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269209 386400380 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862785 NC1CN(C1)S(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C17H17N9O4S3/c18-8-6-26(7-8)33(29,30)12-5-4-9(10-2-1-3-11-14(10)21-17(19)31-11)13(15(12)32(20,27)28)16-22-24-25-23-16/h1-5,8H,6-7,18H2,(H2,19,21)(H2,20,27,28)(H,22,23,24,25) IOQCZQUVXNEXKO-UHFFFAOYSA-N 360991 6-((3-aminoazetidin-1- yl)sulfonyl)-3-(2- aminobenzo[d]thiazol-4-yl)-2- (2H-tetrazol-5- yl)benzenesulfonamide::US10221163, Example 147::US10544130, Example 147 Metallo-beta-lactamase type 2 0.494 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360991 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360991&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269210 386400381 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862788 NC1CCN(CC1)S(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C19H21N9O4S3/c20-10-6-8-28(9-7-10)35(31,32)14-5-4-11(12-2-1-3-13-16(12)23-19(21)33-13)15(17(14)34(22,29)30)18-24-26-27-25-18/h1-5,10H,6-9,20H2,(H2,21,23)(H2,22,29,30)(H,24,25,26,27) LQLKYWFVAIUUME-UHFFFAOYSA-N 360992 3-(2-aminobenzo[d]thiazol-4- yl)-6-((4-aminopiperidin-1- yl)sulfonyl)-2-(2H-tetrazol-5- yl)benzenesulfonamide::US10221163, Example 148::US10544130, Example 148 Metallo-beta-lactamase type 2 0.490 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360992 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360992&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269211 386400382 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862791 Nc1nc2c(cccc2s1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)NCC1(N)CC1 InChI=1S/C18H19N9O4S3/c19-17-23-14-10(2-1-3-11(14)32-17)9-4-5-12(34(30,31)22-8-18(20)6-7-18)15(33(21,28)29)13(9)16-24-26-27-25-16/h1-5,22H,6-8,20H2,(H2,19,23)(H2,21,28,29)(H,24,25,26,27) LBJBSCVPRJVYAR-UHFFFAOYSA-N 360993 4-(2-aminobenzo[d]thiazol-4- yl)-N1-((1- aminocyclopropyl)methyl)-3- (2H-tetrazol-5-yl)benzene-1,2- disulfonamide::US10221163, Example 149::US10544130, Example 149 Metallo-beta-lactamase type 2 0.993 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360993 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360993&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269212 386400383 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862794 CN(C)S(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C16H16N8O4S3/c1-24(2)31(27,28)11-7-6-8(9-4-3-5-10-13(9)19-16(17)29-10)12(14(11)30(18,25)26)15-20-22-23-21-15/h3-7H,1-2H3,(H2,17,19)(H2,18,25,26)(H,20,21,22,23) GBNKXRKFDOPWQQ-UHFFFAOYSA-N 360994 4-(2-aminobenzo[d]thiazol-4- yl)-N1,N1-dimethyl-3-(2H- tetrazol-5-yl)benzene-1,2- disulfonamide::US10221163, Example 151::US10544130, Example 151 Metallo-beta-lactamase type 2 2.43 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360994 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360994&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269213 386400384 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862797 CNS(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C15H14N8O4S3/c1-18-30(26,27)10-6-5-7(8-3-2-4-9-12(8)19-15(16)28-9)11(13(10)29(17,24)25)14-20-22-23-21-14/h2-6,18H,1H3,(H2,16,19)(H2,17,24,25)(H,20,21,22,23) WUABLXKYUAZXNS-UHFFFAOYSA-N 360995 4-(2-aminobezno[d]thiazol-4- yl)-N1-methyl-3-(2H-tetrazol- 5-yl)benzene-1,2- disulfonamide::US10221163, Example 152::US10544130, Example 152 Metallo-beta-lactamase type 2 0.264 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360995 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360995&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269214 386400385 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862800 Nc1nc2c(cccc2s1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)NCC(O)=O InChI=1S/C16H14N8O6S3/c17-16-20-13-8(2-1-3-9(13)31-16)7-4-5-10(33(29,30)19-6-11(25)26)14(32(18,27)28)12(7)15-21-23-24-22-15/h1-5,19H,6H2,(H2,17,20)(H,25,26)(H2,18,27,28)(H,21,22,23,24) HFOJOTOEYNQQED-UHFFFAOYSA-N 360996 ((4-(2-aminobenzo[d]thiazol- 4-yl)-2-sulfamoyl-3-(2H- tetrazol-5- yl)phenyl)sulfonyl)glycine::US10221163, Example 153::US10544130, Example 153 Metallo-beta-lactamase type 2 0.704 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360996 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360996&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269215 386400386 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862803 N[C@H](CNS(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O)C(O)=O 360997 (R)-2-amino-3-((4-(2- aminobenzo[d]thiazol-4-yl)-2- sulfamoyl-3-(2H-tetrazol-5- yl)phenyl)sulfonamido) propanoic acid::US10221163, Example 154::US10544130, Example 154 Metallo-beta-lactamase type 2 0.155 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360997 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360997&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269216 386400387 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862806 Nc1ccc(cn1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(N)(=O)=O InChI=1S/C12H12N8O4S2/c13-9-4-1-6(5-16-9)7-2-3-8(25(14,21)22)11(26(15,23)24)10(7)12-17-19-20-18-12/h1-5H,(H2,13,16)(H2,14,21,22)(H2,15,23,24)(H,17,18,19,20) XXVBQYHIFYSDQC-UHFFFAOYSA-N 360998 4-(6-Aminopyridin-3-yl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 155::US10544130, Example 155 Metallo-beta-lactamase type 2 0.658 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360998 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360998&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124158281 386400388 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862809 CS(=O)(=O)Nc1nc2c(cccc2s1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)N1CCNCC1 InChI=1S/C19H21N9O6S4/c1-36(29,30)25-19-22-16-12(3-2-4-13(16)35-19)11-5-6-14(38(33,34)28-9-7-21-8-10-28)17(37(20,31)32)15(11)18-23-26-27-24-18/h2-6,21H,7-10H2,1H3,(H,22,25)(H2,20,31,32)(H,23,24,26,27) JMROEGRSMUVZFK-UHFFFAOYSA-N 360999 3-(2-(Methylsulfonamido)benzo[d]thiazol-4-yl)-6-(piperazin-1-ylsulfonyl)-2-(2H-tetrazol-5-yl)benzenesulfonamide::US10221163, Example 156::US10544130, Example 156 Metallo-beta-lactamase type 2 0.898 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360999 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360999&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311255 386400389 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862812 Nc1nc2cccc(-c3ccc(c(c3-c3nn[nH]n3)S(N)(=O)=O)S(=O)(=O)N3CCNCC3)c2[nH]1 InChI=1S/C18H20N10O4S2/c19-18-22-12-3-1-2-11(15(12)23-18)10-4-5-13(34(31,32)28-8-6-21-7-9-28)16(33(20,29)30)14(10)17-24-26-27-25-17/h1-5,21H,6-9H2,(H3,19,22,23)(H2,20,29,30)(H,24,25,26,27) DRKUCVWOBRAQJJ-UHFFFAOYSA-N 361000 3-(2-amino-3H-benzo[d]imidazol-4-yl)-6-(piperazin-1-ylsulfonyl)-2-(2H-tetrazol-5-yl)benzenesulfonamide::US10221163, Example 157::US10544130, Example 157 Metallo-beta-lactamase type 2 3.09 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361000 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361000&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124158233 386400390 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862815 Cn1c(N)nc2c(cccc12)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)N1CCNCC1 InChI=1S/C19H22N10O4S2/c1-28-13-4-2-3-12(16(13)23-19(28)20)11-5-6-14(35(32,33)29-9-7-22-8-10-29)17(34(21,30)31)15(11)18-24-26-27-25-18/h2-6,22H,7-10H2,1H3,(H2,20,23)(H2,21,30,31)(H,24,25,26,27) QDKBOVSCISEIKW-UHFFFAOYSA-N 361001 3-(2-amino-1-methyl-1H- benzo[d]imidazol-4-yl)-6- (piperazin-1-ylsulfonyl)-2- (2H-tetrazol-5- yl)benzenesulfonamide::US10221163, Example 158::US10544130, Example 158 Metallo-beta-lactamase type 2 1.71 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361001 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361001&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311055 386400391 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862818 Nc1nc2c(cccc2o1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)N1CCNCC1 InChI=1S/C18H19N9O5S2/c19-18-22-15-11(2-1-3-12(15)32-18)10-4-5-13(34(30,31)27-8-6-21-7-9-27)16(33(20,28)29)14(10)17-23-25-26-24-17/h1-5,21H,6-9H2,(H2,19,22)(H2,20,28,29)(H,23,24,25,26) YFZRDNDRLVDZJA-UHFFFAOYSA-N 361002 3-(2-aminobenzo[d]oxazol-4- yl)-6-(piperazin-1-ylsulfonyl)- 2-(2H-tetrazol-5- yl)benzenesulfonamide::US10221163, Example 159::US10544130, Example 159 Metallo-beta-lactamase type 2 1.29 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361002 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361002&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311817 386400392 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862821 NS(=O)(=O)c1c(ccc(-c2cccc3cn[nH]c23)c1-c1nnn[nH]1)S(=O)(=O)N1CCNCC1 InChI=1S/C18H19N9O4S2/c19-32(28,29)17-14(33(30,31)27-8-6-20-7-9-27)5-4-12(15(17)18-23-25-26-24-18)13-3-1-2-11-10-21-22-16(11)13/h1-5,10,20H,6-9H2,(H,21,22)(H2,19,28,29)(H,23,24,25,26) UMBJQXVDZMLNAG-UHFFFAOYSA-N 361003 3-(1H-indazol-7-yl)-6- (piperazin-1-ylsulfonyl)-2- (1H-tetrazol-5- yl)benzenesulfonamide::US10221163, Example 160::US10544130, Example 160 Metallo-beta-lactamase type 2 1.39 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361003 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361003&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135310816 386400393 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862824 Nc1nc2c(cccc2[nH]1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)NC1CCNC1 InChI=1S/C18H18N10O4S2/c19-18-22-12-3-1-2-11(15(12)23-18)10-4-5-13(34(31,32)26-9-6-7-21-8-9)16(33(20,29)30)14(10)17-24-27-28-25-17/h1-5,9,21,26H,6-8H2,(H2,19,22)(H2,20,29,30)/b11-10+ NLYPTRFLEOKOAY-ZHACJKMWSA-N 361004 4-(2-amino-1H-benzo[d]imidazol-4-yl)-N1—((R)-pyrrolidin-3-yl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 161::US10544130, Example 161 Metallo-beta-lactamase type 2 0.401 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361004 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361004&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135310679 386400394 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862827 Nc1nc2c(cccc2[nH]1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)N[C@H]1CCNC1 InChI=1S/C18H18N10O4S2/c19-18-22-12-3-1-2-11(15(12)23-18)10-4-5-13(34(31,32)26-9-6-7-21-8-9)16(33(20,29)30)14(10)17-24-27-28-25-17/h1-5,9,21,26H,6-8H2,(H2,19,22)(H2,20,29,30)/b11-10+/t9-/m0/s1 NLYPTRFLEOKOAY-YHTNPHCKSA-N 361005 4-(2-amino-1H- benzo[d]imidazol-4-yl)-N1-((S)- pyrrolidin-3-yl)-3-(2H-tetrazol- 5-yl)benzene-1,2-disulfonamide::US10221163, Example 162::US10544130, Example 162 Metallo-beta-lactamase type 2 0.733 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361005 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361005&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311798 386400395 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862830 Cn1c(N)nc2c(cccc12)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)N[C@H]1CCNC1 361006 4-(2-amino-1-methyl-1H- benzo[d]imidazol-4-yl)-N1-((S)- pyrrolidin-3-yl)-3-(2H-tetrazol- 5-yl)benzene-1,2-disulfonamide::US10221163, Example 163::US10544130, Example 163 Metallo-beta-lactamase type 2 0.450 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361006 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361006&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311949 386400396 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862833 Cn1c(N)nc2c(cccc12)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)N[C@@H]1CCNC1 361007 4-(2-amino-1-methyl-1H- benzo[d]imidazol-4-yl)-N1-((R)- pyrrolidin-3-yl)-3-(2H-tetrazol- 5-yl)benzene-1,2-disulfonamide::US10221163, Example 164::US10544130, Example 164 Metallo-beta-lactamase type 2 0.272 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361007 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361007&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311980 386400397 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862836 NC1CCC(CC1)c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(N)(=O)=O InChI=1S/C13H19N7O4S2/c14-8-3-1-7(2-4-8)9-5-6-10(25(15,21)22)12(26(16,23)24)11(9)13-17-19-20-18-13/h5-8H,1-4,14H2,(H2,15,21,22)(H2,16,23,24)(H,17,18,19,20) UTJPHSHUPFTYLW-UHFFFAOYSA-N 361008 4-(4-aminocyclohexyl)-3-(1H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 165::US10544130, Example 165 Metallo-beta-lactamase type 2 24.4 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361008 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361008&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124159653 386400398 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862839 Cn1c(N)nc2c(cccc12)-c1ccc(c(c1-c1nn[n-]n1)S(N)(=O)=O)S(=O)(=O)N[C@H]1CC[N+](C)(C)C1 InChI=1S/C21H26N10O4S2/c1-30-15-6-4-5-14(18(15)24-21(30)22)13-7-8-16(37(34,35)27-12-9-10-31(2,3)11-12)19(36(23,32)33)17(13)20-25-28-29-26-20/h4-8,12,27H,9-11H2,1-3H3,(H4-,22,23,24,25,26,28,29,32,33)/t12-/m0/s1 FLEHXFFEXVWGRV-LBPRGKRZSA-N 361010 (S)-5-(6-(2-amino-1-methyl-1H-benzo[d]imidazol-4-yl)-3-(N-(1,1-dimethylpyrrolidin-1-ium-3-yl)sulfamoyl)-2-sulfamoylphenyl)tetrazol-2-ide::US10221163, Example 167::US10544130, Example 167 Metallo-beta-lactamase type 2 0.820 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361010 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361010&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269219 386400400 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863817 Nc1ccc(cn1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)NCC1(O)CCNCC1 InChI=1S/C18H23N9O5S2/c19-14-4-1-11(9-22-14)12-2-3-13(16(33(20,29)30)15(12)17-24-26-27-25-17)34(31,32)23-10-18(28)5-7-21-8-6-18/h1-4,9,21,23,28H,5-8,10H2,(H2,19,22)(H2,20,29,30)(H,24,25,26,27) YUFZAQCMPXKUOU-UHFFFAOYSA-N 361335 4-(6-aminopyridin-3-yl)- N1-((4-hydroxypiperidin- 4-yl)methyl)-3-(2H- tetrazol-5-yl)benzene-1,2 disulfonamide::US10221163, Example 492::US10544130, Example 492 Metallo-beta-lactamase type 2 0.520 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361335 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361335&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311793 386400722 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863820 Nc1ccc(cn1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)NC1CNC1 InChI=1S/C15H17N9O4S2/c16-12-4-1-8(5-19-12)10-2-3-11(30(27,28)22-9-6-18-7-9)14(29(17,25)26)13(10)15-20-23-24-21-15/h1-5,9,18,22H,6-7H2,(H2,16,19)(H2,17,25,26)(H,20,21,23,24) LETKBQVLHMERPP-UHFFFAOYSA-N 361336 4-(6-aminopyridin-3-yl)- N1-(azetidin-3-yl)-3-(2H- tetrazol-5-yl)benzene-1,2- disulfonamide::US10221163, Example 493::US10544130, Example 493 Metallo-beta-lactamase type 2 0.403 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361336 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361336&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311301 386400723 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863823 Nc1ccc(cn1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)N[C@H]1CCCNC1 361337 (S)-4-(6-aminopyridin-3- yl)-N1-(piperidin-3-yl)-3- (2H-tetrazol-5- yl)benzene-1,2- disulfonamide::US10221163, Example 494::US10544130, Example 494 Metallo-beta-lactamase type 2 0.808 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361337 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361337&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311057 386400724 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863826 Nc1ccc(cn1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)NCC1(O)CNC1 InChI=1S/C16H19N9O5S2/c17-12-4-1-9(5-20-12)10-2-3-11(32(29,30)21-8-16(26)6-19-7-16)14(31(18,27)28)13(10)15-22-24-25-23-15/h1-5,19,21,26H,6-8H2,(H2,17,20)(H2,18,27,28)(H,22,23,24,25) ZULUBCFYHQEBJW-UHFFFAOYSA-N 361338 4-(6-aminopyridin-3-yl)- N1-((3-hydroxyazetidin-3- yl)methyl)-3-(2H-tetrazol- 5-yl)benzene-1,2- disulfonamide::US10221163, Example 495::US10544130, Example 495 Metallo-beta-lactamase type 2 0.328 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361338 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361338&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135310686 386400725 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863829 NCCCNS(=O)(=O)c1ccc(-c2ccc(N)nc2)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C15H19N9O4S2/c16-6-1-7-20-30(27,28)11-4-3-10(9-2-5-12(17)19-8-9)13(14(11)29(18,25)26)15-21-23-24-22-15/h2-5,8,20H,1,6-7,16H2,(H2,17,19)(H2,18,25,26)(H,21,22,23,24) PFGLEWSOALRQSL-UHFFFAOYSA-N 361339 N1-(3-aminopropyl)-4-(6- aminopyridin-3-yl)-3-(2H- tetrazol-5-yl)benzene-1,2- disulfonamide hydrogen chloride::US10221163, Example 496::US10544130, Example 496 Metallo-beta-lactamase type 2 0.576 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361339 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361339&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311929 386400726 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863832 CC1(CNC1)NS(=O)(=O)c1ccc(-c2ccc(N)nc2)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C16H19N9O4S2/c1-16(7-19-8-16)23-31(28,29)11-4-3-10(9-2-5-12(17)20-6-9)13(14(11)30(18,26)27)15-21-24-25-22-15/h2-6,19,23H,7-8H2,1H3,(H2,17,20)(H2,18,26,27)(H,21,22,24,25) HGICSZSMZDNVQQ-UHFFFAOYSA-N 361340 4-(6-aminopyridin-3-yl)- 1-N-(3-methylazetidin-3- yl)-3-(2H-1,2,3,4-tetrazol- 5-yl)benzene-1,2- disulfonamide hydrogen::US10221163, Example 497::US10544130, Example 497 Metallo-beta-lactamase type 2 0.645 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361340 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361340&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 137537629 386400727 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863835 C[C@H](CCN)NS(=O)(=O)c1ccc(-c2ccc(N)nc2)c(-c2nn[nH]n2)c1S(N)(=O)=O 361341 (R)-N1-(4-aminobutan-2- yl)-4-(6-aminopyridin-3- yl)-3-(1H-tetrazol-5- yl)benzene-1,2- disulfonamide::US10221163, Example 498::US10544130, Example 498 Metallo-beta-lactamase type 2 0.076 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361341 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361341&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311649 386400728 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863838 C[C@@H](CCN)NS(=O)(=O)c1ccc(-c2ccc(N)nc2)c(-c2nn[nH]n2)c1S(N)(=O)=O 361342 (S)-N1-(4-aminobutan-2- yl)-4-(6-aminopyridin-3- yl)-3-(1H-tetrazol-5- yl)benzene-1,2- disulfonamide::US10221163, Example 499::US10544130, Example 499 Metallo-beta-lactamase type 2 1.02 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361342 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361342&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311453 386400729 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863841 NCCN1CCC(C1)NS(=O)(=O)c1ccc(-c2ccc(N)nc2)c(-c2nn[nH]n2)c1S(N)(=O)=O 427664 (R)—N1-(1-(2-aminoethyl)pyrrolidin-3-yl)-4-(6-aminopyridin-3-yl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10544130, Example 500 Metallo-beta-lactamase type 2 0.164 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=427664 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=427664&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311401 434317428 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862842 Cn1c(N)nc2c(cccc12)-c1ccc(c(c1-c1nn[n-]n1)S(N)(=O)=O)S(=O)(=O)N[C@H]1CC[N+](C)(C)C1 InChI=1S/C21H26N10O4S2/c1-30-15-6-4-5-14(18(15)24-21(30)22)13-7-8-16(37(34,35)27-12-9-10-31(2,3)11-12)19(36(23,32)33)17(13)20-25-28-29-26-20/h4-8,12,27H,9-11H2,1-3H3,(H4-,22,23,24,25,26,28,29,32,33)/t12-/m0/s1 FLEHXFFEXVWGRV-LBPRGKRZSA-N 361010 (S)-5-(6-(2-amino-1-methyl-1H-benzo[d]imidazol-4-yl)-3-(N-(1,1-dimethylpyrrolidin-1-ium-3-yl)sulfamoyl)-2-sulfamoylphenyl)tetrazol-2-ide::US10221163, Example 167::US10544130, Example 167 Metallo-beta-lactamase type 2 0.346 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361010 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361010&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269219 386400400 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862845 Nc1nc2c(cccc2[nH]1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)N[C@H]1CNC[C@H]1O InChI=1S/C18H18N10O5S2/c19-18-22-10-3-1-2-9(15(10)23-18)8-4-5-13(35(32,33)26-11-6-21-7-12(11)29)16(34(20,30)31)14(8)17-24-27-28-25-17/h1-5,11-12,21,26,29H,6-7H2,(H2,19,22)(H2,20,30,31)/b9-8+/t11-,12+/m0/s1 KQMMMLLEOPMFOS-VDTGWRSZSA-N 361011 4-(2-amino-1H-benzo[d]imidazol-4-yl)-N1-(3S,4R)-4-hydroxypyrrolidin-3-yl)-3-(1H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 168::US10544130, Example 168 Metallo-beta-lactamase type 2 0.544 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361011 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361011&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124159594 386400401 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862848 Nc1nc2c(cccc2[nH]1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)N[C@H]1CNC[C@@H]1O InChI=1S/C18H18N10O5S2/c19-18-22-10-3-1-2-9(15(10)23-18)8-4-5-13(35(32,33)26-11-6-21-7-12(11)29)16(34(20,30)31)14(8)17-24-27-28-25-17/h1-5,11-12,21,26,29H,6-7H2,(H2,19,22)(H2,20,30,31)/b9-8-/t11-,12-/m0/s1 KQMMMLLEOPMFOS-RTVKQWPZSA-N 361012 4-(2-amino-1H- benzo[d]imidazol-4-yl)-N1- ((3S,4S)-4-hydroxypyrrolidin-3- yl)-3-(1H-tetrazol-5- yl)benzene-1,2-disulfonamide::US10221163, Example 169::US10544130, Example 169 Metallo-beta-lactamase type 2 2.08 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361012 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361012&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311791 386400402 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862851 Nc1nc2c(cccc2[nH]1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)N[C@@H]1CNC[C@@H]1O InChI=1S/C18H18N10O5S2/c19-18-22-10-3-1-2-9(15(10)23-18)8-4-5-13(35(32,33)26-11-6-21-7-12(11)29)16(34(20,30)31)14(8)17-24-27-28-25-17/h1-5,11-12,21,26,29H,6-7H2,(H2,19,22)(H2,20,30,31)/b9-8-/t11-,12+/m1/s1 KQMMMLLEOPMFOS-STNFYNBXSA-N 361013 4-(2-amino-1H- benzo[d]imidazol-4-yl)-N1- ((3R,4S)-4-hydroxypyrrolidin- 3-yl)-3-(1H-tetrazol-5- yl)benzene-1,2-disulfonamide::US10221163, Example 170::US10544130, Example 170 Metallo-beta-lactamase type 2 1.12 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361013 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361013&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135310942 386400403 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862854 Nc1nc2c(cccc2[nH]1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)N[C@@H]1CNC[C@H]1O InChI=1S/C18H18N10O5S2/c19-18-22-10-3-1-2-9(15(10)23-18)8-4-5-13(35(32,33)26-11-6-21-7-12(11)29)16(34(20,30)31)14(8)17-24-27-28-25-17/h1-5,11-12,21,26,29H,6-7H2,(H2,19,22)(H2,20,30,31)/b9-8-/t11-,12-/m1/s1 KQMMMLLEOPMFOS-DSWQZHNZSA-N 361014 4-(2-amino-1H- benzo[d]imidazol-4-yl)-N1- ((3R,4R)-4-hydroxypyrrolidin- 3-yl)-3-(1H-tetrazol-5- yl)benzene-1,2-disulfonamide::US10221163, Example 171::US10544130, Example 171 Metallo-beta-lactamase type 2 1.39 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361014 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361014&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311865 386400404 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862857 Nc1nc2c(cccc2[nH]1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)N[C@H]1CN[C@H](CO)C1 InChI=1S/C19H20N10O5S2/c20-19-23-13-3-1-2-12(16(13)24-19)11-4-5-14(36(33,34)27-9-6-10(8-30)22-7-9)17(35(21,31)32)15(11)18-25-28-29-26-18/h1-5,9-10,22,27,30H,6-8H2,(H2,20,23)(H2,21,31,32)/b12-11-/t9-,10+/m1/s1 WQRBNQMLJQOESH-VYEBIXSXSA-N 361015 4-(2-amino-1H- benzo[d]imidazol-4-yl)-N1- ((3R,5S)-5- (hydroxymethyl)pyrrolidin-3- yl)-3-(1H-tetrazol-5- yl)benzene-1,2-disulfonamide::US10221163, Example 172::US10544130, Example 172 Metallo-beta-lactamase type 2 0.509 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361015 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361015&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311287 386400405 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862860 Nc1nc2c(cccc2[nH]1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)N[C@H]1CN[C@@H](CO)C1 InChI=1S/C19H20N10O5S2/c20-19-23-13-3-1-2-12(16(13)24-19)11-4-5-14(36(33,34)27-9-6-10(8-30)22-7-9)17(35(21,31)32)15(11)18-25-28-29-26-18/h1-5,9-10,22,27,30H,6-8H2,(H2,20,23)(H2,21,31,32)/b12-11-/t9-,10-/m1/s1 WQRBNQMLJQOESH-WNPRHHQDSA-N 361016 4-(2-amino-1H- benzo[d]imidazol-4-yl)-N1- ((3R,5R)-5- (hydroxymethyl)pyrrolidin-3- yl)-3-(1H-tetrazol-5- yl)benzene-1,2-disulfonamide::US10221163, Example 173::US10544130, Example 173 Metallo-beta-lactamase type 2 0.933 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361016 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361016&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135310673 386400406 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862863 Nc1nc2c(cccc2[nH]1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)N[C@@H]1CN[C@@H](CO)C1 InChI=1S/C19H20N10O5S2/c20-19-23-13-3-1-2-12(16(13)24-19)11-4-5-14(36(33,34)27-9-6-10(8-30)22-7-9)17(35(21,31)32)15(11)18-25-28-29-26-18/h1-5,9-10,22,27,30H,6-8H2,(H2,20,23)(H2,21,31,32)/b12-11-/t9-,10+/m0/s1 WQRBNQMLJQOESH-FQHHDQPRSA-N 361017 4-(2-amino-1H- benzo[d]imidazol-4-yl)-N1- ((3S,5R)-5- (hydroxymethyl)pyrrolidin-3- yl)-3-(1H-tetrazol-5- yl)benzene-1,2-disulfonamide::US10221163, Example 174::US10544130, Example 174 Metallo-beta-lactamase type 2 1.66 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361017 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361017&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311033 386400407 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862866 Nc1nc2c(cccc2[nH]1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)N[C@@H]1CN[C@H](CO)C1 InChI=1S/C19H20N10O5S2/c20-19-23-13-3-1-2-12(16(13)24-19)11-4-5-14(36(33,34)27-9-6-10(8-30)22-7-9)17(35(21,31)32)15(11)18-25-28-29-26-18/h1-5,9-10,22,27,30H,6-8H2,(H2,20,23)(H2,21,31,32)/b12-11-/t9-,10-/m0/s1 WQRBNQMLJQOESH-DDSNRYIPSA-N 361018 4-(2-amino-1H- benzo[d]imidazol-4-yl)-N1- ((3S,5S)-5- (hydroxymethyl)pyrrolidin-3- yl)-3-(1H-tetrazol-5- yl)benzene-1,2-disulfonamide::US10221163, Example 175::US10544130, Example 175 Metallo-beta-lactamase type 2 1.00 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361018 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361018&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311440 386400408 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862869 Nc1nc2c(cccc2[nH]1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)N[C@@]1(CO)CCNC1 InChI=1S/C19H20N10O5S2/c20-18-23-12-3-1-2-11(15(12)24-18)10-4-5-13(36(33,34)27-19(9-30)6-7-22-8-19)16(35(21,31)32)14(10)17-25-28-29-26-17/h1-5,22,27,30H,6-9H2,(H2,20,23)(H2,21,31,32)/b11-10-/t19-/m0/s1 WPMCUEUBPIRDFI-GDWUOILNSA-N 361019 (S)-4-(2-amino-1H- benzo[d]imidazol-4-yl)-N1-(3- (hydroxymethyl)pyrrolidin-3- yl)-3-(1H-tetrazol-5- yl)benzene-1,2-disulfonamide::US10221163, Example 176::US10544130, Example 176 Metallo-beta-lactamase type 2 0.728 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361019 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361019&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311531 386400409 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862872 Nc1nc2c(cccc2[nH]1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)N[C@]1(CO)CCNC1 InChI=1S/C19H20N10O5S2/c20-18-23-12-3-1-2-11(15(12)24-18)10-4-5-13(36(33,34)27-19(9-30)6-7-22-8-19)16(35(21,31)32)14(10)17-25-28-29-26-17/h1-5,22,27,30H,6-9H2,(H2,20,23)(H2,21,31,32)/b11-10-/t19-/m1/s1 WPMCUEUBPIRDFI-OEIFXAAASA-N 361020 (R)-4-(2-amino-1H- benzo[d]imidazol-4-yl)-N1-(3- (hydroxymethyl)pyrrolidin-3- yl)-3-(1H-tetrazol-5- yl)benzene-1,2-disulfonamide::US10221163, Example 177::US10544130, Example 177 Metallo-beta-lactamase type 2 0.862 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361020 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361020&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311396 386400410 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862875 Nc1nc2c(cccc2[nH]1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)N[C@@H]1CCCNC1 InChI=1S/C19H20N10O4S2/c20-19-23-13-5-1-4-12(16(13)24-19)11-6-7-14(35(32,33)27-10-3-2-8-22-9-10)17(34(21,30)31)15(11)18-25-28-29-26-18/h1,4-7,10,22,27H,2-3,8-9H2,(H2,20,23)(H2,21,30,31)/b12-11+/t10-/m1/s1 GTWUEQKXNBYLDY-PJSNMCHCSA-N 361021 (R)-4-(2-amino-1H-benzo[d]imidazol-4-yl)-N1-(piperidin-3-yl)-3-(1H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 178::US10544130, Example 178 Metallo-beta-lactamase type 2 0.870 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361021 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361021&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124159589 386400411 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862878 Nc1nc2c(cccc2[nH]1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)N[C@H]1CCCNC1 InChI=1S/C19H20N10O4S2/c20-19-23-13-5-1-4-12(16(13)24-19)11-6-7-14(35(32,33)27-10-3-2-8-22-9-10)17(34(21,30)31)15(11)18-25-28-29-26-18/h1,4-7,10,22,27H,2-3,8-9H2,(H2,20,23)(H2,21,30,31)/b12-11-/t10-/m0/s1 GTWUEQKXNBYLDY-OQDIYGIBSA-N 361022 (S)-4-(2-amino-1H- benzo[d]imidazol-4-yl)-N1- (piperidin-3-yl)-3-(1H-tetrazol- 5-yl)benzene-1,2-disulfonamide::US10221163, Example 179::US10544130, Example 179 Metallo-beta-lactamase type 2 3.00 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361022 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361022&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311097 386400412 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862881 NCCNS(=O)(=O)c1ccc(-c2cc(F)cc3[nH]c(N)nc23)c(-c2nnn[nH]2)c1S(N)(=O)=O InChI=1S/C16H17FN10O4S2/c17-7-5-9(13-10(6-7)22-16(19)23-13)8-1-2-11(33(30,31)21-4-3-18)14(32(20,28)29)12(8)15-24-26-27-25-15/h1-2,5-6,21H,3-4,18H2,(H3,19,22,23)(H2,20,28,29)(H,24,25,26,27) UELOJMHIIBZDFG-UHFFFAOYSA-N 361023 4-(2-amino-6-fluoro-1H- benzo[d]imidazol-4-yl)-N1-(2- aminoethyl)-3-(1H-tetrazol-5- yl)benzene-1,2-disulfonamide::US10221163, Example 180::US10544130, Example 180 Metallo-beta-lactamase type 2 0.387 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361023 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361023&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311708 386400413 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862884 Nc1nc2c(cc(F)cc2[nH]1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)N[C@@H]1CCNC1 InChI=1S/C18H17FN10O4S2/c19-8-5-11(15-12(6-8)23-18(20)24-15)10-1-2-13(35(32,33)27-9-3-4-22-7-9)16(34(21,30)31)14(10)17-25-28-29-26-17/h1-2,5-6,9,22,27H,3-4,7H2,(H2,20,23)(H2,21,30,31)/b11-10+/t9-/m1/s1 SXTBYHWGGXCMBX-HNLKAFMCSA-N 361024 (R)-4-(2-amino-6-fluoro-1H- benzo[d]imidazol-4-yl)-N1- (pyrrolidin-3-yl)-3-(1H-tetrazol- 5-yl)benzene-1,2-disulfonamide::US10221163, Example 181::US10544130, Example 181 Metallo-beta-lactamase type 2 0.273 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361024 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361024&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311336 386400414 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862887 NCCCNS(=O)(=O)c1ccc(-c2cccc3[nH]c(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C17H20N10O4S2/c18-7-2-8-21-33(30,31)12-6-5-9(10-3-1-4-11-14(10)23-17(19)22-11)13(15(12)32(20,28)29)16-24-26-27-25-16/h1,3-6,21H,2,7-8,18H2,(H3,19,22,23)(H2,20,28,29)(H,24,25,26,27) BFOYHAUOQCJINB-UHFFFAOYSA-N 361025 4-(2-amino-1H-benzo[d]imidazol-4-yl)-N1-(3-aminopropyl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 182::US10544130, Example 182 Metallo-beta-lactamase type 2 0.453 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361025 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361025&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124159615 386400415 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862890 Cn1c(N)nc2c(cccc12)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)NCCCN InChI=1S/C18H22N10O4S2/c1-28-12-5-2-4-11(15(12)23-18(28)20)10-6-7-13(34(31,32)22-9-3-8-19)16(33(21,29)30)14(10)17-24-26-27-25-17/h2,4-7,22H,3,8-9,19H2,1H3,(H2,20,23)(H2,21,29,30)(H,24,25,26,27) UBSHWFYWCAQXGO-UHFFFAOYSA-N 361026 4-(2-amino-1-methyl-1H-benzo[d]imidazol-4-yl)-N1-(3-aminopropyl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 183::US10544130, Example 183 Metallo-beta-lactamase type 2 0.338 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361026 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361026&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124159607 386400416 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862893 C[C@H](N)CNS(=O)(=O)c1ccc(-c2cccc3[nH]c(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C17H18N10O4S2/c1-8(18)7-21-33(30,31)12-6-5-9(10-3-2-4-11-14(10)23-17(19)22-11)13(15(12)32(20,28)29)16-24-26-27-25-16/h2-6,8,21H,7,18H2,1H3,(H2,19,22)(H2,20,28,29)/b10-9+/t8-/m0/s1 BZRATMYQIUECIG-VPOJCXOPSA-N 361027 4-(2-amino-1H-benzo[d]imidazol-4-yl)-N1-((S)-2-aminopropyl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 184::US10544130, Example 184 Metallo-beta-lactamase type 2 0.673 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361027 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361027&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124159687 386400417 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862896 C[C@@H](N)CNS(=O)(=O)c1ccc(-c2cccc3[nH]c(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C17H18N10O4S2/c1-8(18)7-21-33(30,31)12-6-5-9(10-3-2-4-11-14(10)23-17(19)22-11)13(15(12)32(20,28)29)16-24-26-27-25-16/h2-6,8,21H,7,18H2,1H3,(H2,19,22)(H2,20,28,29)/b10-9+/t8-/m1/s1 BZRATMYQIUECIG-KGSKPCQNSA-N 361028 4-(2-amino-1H-benzo[d]imidazol-4-yl)-N1-((R)-2-aminopropyl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 185::US10544130, Example 185 Metallo-beta-lactamase type 2 0.524 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361028 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361028&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124159698 386400418 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862899 C[C@@H](CN)NS(=O)(=O)c1ccc(-c2cccc3[nH]c(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C17H18N10O4S2/c1-8(7-18)25-33(30,31)12-6-5-9(10-3-2-4-11-14(10)22-17(19)21-11)13(15(12)32(20,28)29)16-23-26-27-24-16/h2-6,8,25H,7,18H2,1H3,(H2,19,21)(H2,20,28,29)/b10-9+/t8-/m0/s1 WQHJTRWTMBJTIA-VPOJCXOPSA-N 361029 4-(2-amino-1H-benzo[d]imidazol-4-yl)-N1—(S)-1-aminopropan-2-yl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 186::US10544130, Example 186 Metallo-beta-lactamase type 2 4.09 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361029 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361029&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124159632 386400419 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862902 C[C@H](CN)NS(=O)(=O)c1ccc(-c2cccc3[nH]c(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C17H18N10O4S2/c1-8(7-18)25-33(30,31)12-6-5-9(10-3-2-4-11-14(10)22-17(19)21-11)13(15(12)32(20,28)29)16-23-26-27-24-16/h2-6,8,25H,7,18H2,1H3,(H2,19,21)(H2,20,28,29)/b10-9+/t8-/m1/s1 WQHJTRWTMBJTIA-KGSKPCQNSA-N 361030 4-(2-amino-1H-benzo[d]imidazol-4-yl)-N1—((R)-1-aminopropan-2-yl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 187::US10544130, Example 187 Metallo-beta-lactamase type 2 0.230 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361030 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361030&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124159697 386400420 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862905 N[C@H](CNS(=O)(=O)c1ccc(-c2cccc3[nH]c(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O)C(N)=O InChI=1S/C17H17N11O5S2/c18-9(15(19)29)6-22-35(32,33)11-5-4-7(8-2-1-3-10-13(8)24-17(20)23-10)12(14(11)34(21,30)31)16-25-27-28-26-16/h1-5,9,22H,6,18H2,(H2,19,29)(H2,20,23)(H2,21,30,31)/b8-7+/t9-/m1/s1 HEBMKFORMCSKAU-FCZSHJHJSA-N 361031 (2R)-2-amino-3-(4-(2-amino-1H-benzo[d]imidazol-4-yl)-2-sulfamoyl-3-(2H-tetrazol-5-yl)phenylsulfonamido)propanamide::US10221163, Example 188::US10544130, Example 188 Metallo-beta-lactamase type 2 0.613 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361031 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361031&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124159701 386400421 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862908 N[C@@H](CNS(=O)(=O)c1ccc(-c2cccc3[nH]c(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O)C(N)=O InChI=1S/C17H17N11O5S2/c18-9(15(19)29)6-22-35(32,33)11-5-4-7(8-2-1-3-10-13(8)24-17(20)23-10)12(14(11)34(21,30)31)16-25-27-28-26-16/h1-5,9,22H,6,18H2,(H2,19,29)(H2,20,23)(H2,21,30,31)/b8-7+/t9-/m0/s1 HEBMKFORMCSKAU-FLOXNTQESA-N 361032 (2S)-2-amino-3-(4-(2-amino-1H-benzo[d]imidazol-4-yl)-2-sulfamoyl-3-(2H-tetrazol-5-yl)phenylsulfonamido)propanamide::US10221163, Example 189::US10544130, Example 189 Metallo-beta-lactamase type 2 0.615 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361032 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361032&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124159605 386400422 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862911 N[C@@H](CO)CNS(=O)(=O)c1ccc(-c2cccc3[nH]c(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C17H18N10O5S2/c18-8(7-28)6-21-34(31,32)12-5-4-9(10-2-1-3-11-14(10)23-17(19)22-11)13(15(12)33(20,29)30)16-24-26-27-25-16/h1-5,8,21,28H,6-7,18H2,(H2,19,22)(H2,20,29,30)/b10-9+/t8-/m1/s1 KMTZHEVZIGIVOI-KGSKPCQNSA-N 361033 4-(2-amino-1H-benzo[d]imidazol-4-yl)-N1-((R)-2-amino-3-hydroxypropyl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 190::US10544130, Example 190 Metallo-beta-lactamase type 2 0.624 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361033 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361033&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124159603 386400423 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862914 N[C@H](CO)CNS(=O)(=O)c1ccc(-c2cccc3[nH]c(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C17H18N10O5S2/c18-8(7-28)6-21-34(31,32)12-5-4-9(10-2-1-3-11-14(10)23-17(19)22-11)13(15(12)33(20,29)30)16-24-26-27-25-16/h1-5,8,21,28H,6-7,18H2,(H2,19,22)(H2,20,29,30)/b10-9+/t8-/m0/s1 KMTZHEVZIGIVOI-VPOJCXOPSA-N 361034 4-(2-amino-1H-benzo[d]imidazol-4-yl)-N1—((S)-2-amino-3-hydroxypropyl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 191::US10544130, Example 191 Metallo-beta-lactamase type 2 0.433 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361034 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361034&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124159613 386400424 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862917 NC(=N)c1nc2c(cccc2s1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(N)(=O)=O InChI=1S/C15H13N9O4S3/c16-13(17)15-20-11-7(2-1-3-8(11)29-15)6-4-5-9(30(18,25)26)12(31(19,27)28)10(6)14-21-23-24-22-14/h1-5H,(H3,16,17)(H2,18,25,26)(H2,19,27,28)(H,21,22,23,24) PLYWKYGTXVRZIM-UHFFFAOYSA-N 361035 4-(3,4-disulfamoyl-2-(2H-tetrazol-5-yl)phenyl)benzo[d]thiazole-2-carboximidamide::US10221163, Example 192::US10544130, Example 192 Metallo-beta-lactamase type 2 0.699 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361035 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361035&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124159606 386400425 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862920 NS(=O)(=O)c1c(ccc(-c2cccc3[nH]cnc23)c1-c1nn[nH]n1)S(=O)(=O)N[C@@H]1CCNC1 InChI=1S/C18H17N9O4S2/c19-32(28,29)17-14(33(30,31)25-10-6-7-20-8-10)5-4-11(15(17)18-23-26-27-24-18)12-2-1-3-13-16(12)22-9-21-13/h1-5,9-10,20,25H,6-8H2,(H2,19,28,29)/b12-11+/t10-/m1/s1 QTIHTTAMZWPUFN-PJSNMCHCSA-N 361036 4-(1H-benzo[d]imidazol-4-yl)-N1-((R)-pyrrolidin-3-yl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 193::US10544130, Example 193 Metallo-beta-lactamase type 2 0.211 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361036 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361036&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135310900 386400426 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862923 Nc1ccc(cn1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)N[C@@H]1CCNC1 361037 (R)-4-(6-aminopyridin-3-yl)-N1-(pyrrolidin-3-yl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 194::US10544130, Example 194 Metallo-beta-lactamase type 2 0.242 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361037 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361037&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124158480 386400427 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862926 Nc1ccc(cn1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)N[C@H]1CCNC1 361038 (S)-4-(6-aminopyridin-3-yl)-N1-(pyrrolidin-3-yl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 195::US10544130, Example 195 Metallo-beta-lactamase type 2 0.523 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361038 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361038&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124159643 386400428 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862929 NCCNS(=O)(=O)c1ccc(-c2ccc(N)nc2)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C14H17N9O4S2/c15-5-6-19-29(26,27)10-3-2-9(8-1-4-11(16)18-7-8)12(13(10)28(17,24)25)14-20-22-23-21-14/h1-4,7,19H,5-6,15H2,(H2,16,18)(H2,17,24,25)(H,20,21,22,23) KXELUNLBQPTQIB-UHFFFAOYSA-N 361039 N1-(2-aminoethyl)-4-(6-aminopyridin-3-yl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 196::US10544130, Example 196 Metallo-beta-lactamase type 2 0.479 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361039 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361039&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124158237 386400429 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862932 NS(=O)(=O)c1c(ccc(-c2cccc3[nH]cnc23)c1-c1nn[nH]n1)S(=O)(=O)N[C@H]1CCNC1 InChI=1S/C18H17N9O4S2/c19-32(28,29)17-14(33(30,31)25-10-6-7-20-8-10)5-4-11(15(17)18-23-26-27-24-18)12-2-1-3-13-16(12)22-9-21-13/h1-5,9-10,20,25H,6-8H2,(H2,19,28,29)/b12-11+/t10-/m0/s1 QTIHTTAMZWPUFN-IUZMTQGWSA-N 361040 4-(1H-benzo[d]imidazol-4-yl)-N1—(S)-pyrrolidin-3-yl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 197::US10544130, Example 197 Metallo-beta-lactamase type 2 0.395 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361040 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361040&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124159675 386400430 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862935 NCCCNS(=O)(=O)c1ccc(-c2cccc3[nH]cnc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C17H19N9O4S2/c18-7-2-8-22-32(29,30)13-6-5-10(11-3-1-4-12-15(11)21-9-20-12)14(16(13)31(19,27)28)17-23-25-26-24-17/h1,3-6,9,22H,2,7-8,18H2,(H,20,21)(H2,19,27,28)(H,23,24,25,26) PULJZVSXVWZSIQ-UHFFFAOYSA-N 361041 N1-(3-aminopropyl)-4-(1H-benzo[d]imidazol-4-yl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 198::US10544130, Example 198 Metallo-beta-lactamase type 2 0.293 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361041 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361041&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124159585 386400431 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862938 NCCNS(=O)(=O)c1ccc(-c2cccc3[nH]cnc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C16H17N9O4S2/c17-6-7-21-31(28,29)12-5-4-9(10-2-1-3-11-14(10)20-8-19-11)13(15(12)30(18,26)27)16-22-24-25-23-16/h1-5,8,21H,6-7,17H2,(H,19,20)(H2,18,26,27)(H,22,23,24,25) ABGWLUMGGAKQLX-UHFFFAOYSA-N 361042 N1-(2-aminoethyl)-4-(1H-benzo[d]imidazol-4-yl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 199::US10544130, Example 199 Metallo-beta-lactamase type 2 0.102 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361042 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361042&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124159679 386400432 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862941 N[C@H]1C[C@@H](C1)NS(=O)(=O)c1ccc(-c2cccc3[nH]cnc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C18H17N9O4S2/c19-9-6-10(7-9)25-33(30,31)14-5-4-11(12-2-1-3-13-16(12)22-8-21-13)15(17(14)32(20,28)29)18-23-26-27-24-18/h1-5,8-10,25H,6-7,19H2,(H2,20,28,29)/b12-11+/t9-,10- LRCUVYRGBKTSDV-SXPMVVMESA-N 361043 N1-((1r,3r)-3-aminocyclobutyl)-4-(1H-benzo[d]imidazol-4-yl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 200::US10544130, Example 200 Metallo-beta-lactamase type 2 0.276 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361043 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361043&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124159650 386400433 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862944 NCC(CO)NS(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nnn[nH]2)c1S(N)(=O)=O 361044 (S)—N1-(1-amino-3-hydroxypropan-2-yl)-4-(2-aminobenzo[d]thiazol-4-yl)-3-(1H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 201::US10544130, Example 201 Metallo-beta-lactamase type 2 0.109 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361044 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361044&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135310725 386400434 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862947 NC[C@H](CO)NS(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nnn[nH]2)c1S(N)(=O)=O 361045 (R)—N1-(1-amino-3-hydroxypropan-2-yl)-4-(2-aminobenzo[d]thiazol-4-yl)-3-(1H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 202::US10544130, Example 202 Metallo-beta-lactamase type 2 0.713 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361045 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361045&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135310972 386400435 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862950 NCCOCCNS(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nnn[nH]2)c1S(N)(=O)=O InChI=1S/C18H21N9O5S3/c19-6-8-32-9-7-22-35(30,31)13-5-4-10(11-2-1-3-12-15(11)23-18(20)33-12)14(16(13)34(21,28)29)17-24-26-27-25-17/h1-5,22H,6-9,19H2,(H2,20,23)(H2,21,28,29)(H,24,25,26,27) KCKDRBGQJWHVTE-UHFFFAOYSA-N 361046 4-(2-aminobenzo[d]thiazol-4-yl)-N1-(2-(2-aminoethoxy)ethyl)-3-(1H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 203::US10544130, Example 203 Metallo-beta-lactamase type 2 0.199 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361046 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361046&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124158475 386400436 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862953 NCCNC(=O)c1cccc(c1N)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)NCCN InChI=1S/C18H24N10O5S2/c19-6-8-23-18(29)12-3-1-2-11(15(12)21)10-4-5-13(35(32,33)24-9-7-20)16(34(22,30)31)14(10)17-25-27-28-26-17/h1-5,24H,6-9,19-21H2,(H,23,29)(H2,22,30,31)(H,25,26,27,28) KJCSBMYFBQKAEH-UHFFFAOYSA-N 361047 2-amino-N-(2-aminoethyl)-4′-(N-(2-aminoethyl)sulfamoyl)-5′-sulfamoyl-6′-(2H-tetrazol-5-yl)biphenyl-3-carboxamide::US10221163, Example 204::US10544130, Example 204 Metallo-beta-lactamase type 2 2.56 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361047 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361047&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124158412 386400437 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862956 N[C@@H]1CN(CC[C@H]1F)S(=O)(=O)c1ccc(-c2cccc3[nH]c(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C19H21FN10O4S2/c20-11-6-7-30(8-12(11)21)36(33,34)14-5-4-9(10-2-1-3-13-16(10)25-19(22)24-13)15(17(14)35(23,31)32)18-26-28-29-27-18/h1-5,11-12H,6-8,21H2,(H3,22,24,25)(H2,23,31,32)(H,26,27,28,29)/t11-,12-/m1/s1 JZQVOGXMDSVEHZ-VXGBXAGGSA-N 361048 3-(2-amino-1H-benzo[d]imidazol-4-yl)-6-(((3R,4R)-3-amino-4-fluoropiperidin-1-yl)sulfonyl)-2-(2H-tetrazol-5-yl)benzenesulfonamide::US10221163, Example 205::US10544130, Example 205 Metallo-beta-lactamase type 2 5.89 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361048 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361048&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124158291 386400438 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862959 Nc1nc2c(cccc2[nH]1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)NCC1COCCN1 InChI=1S/C19H20N10O5S2/c20-19-24-13-3-1-2-12(16(13)25-19)11-4-5-14(36(32,33)23-8-10-9-34-7-6-22-10)17(35(21,30)31)15(11)18-26-28-29-27-18/h1-5,10,22-23H,6-9H2,(H2,20,24)(H2,21,30,31)/b12-11- CYOWKSPYSUDGIS-QXMHVHEDSA-N 361049 4-(2-amino-1H-benzo[d]imidazol-4-yl)-N1-(morpholin-3-ylmethyl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 206::US10544130, Example 206 Metallo-beta-lactamase type 2 0.498 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361049 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361049&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135310743 386400439 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862962 Nc1nc2c(cccc2[nH]1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)NCC1CCN1 InChI=1S/C18H18N10O4S2/c19-18-23-12-3-1-2-11(15(12)24-18)10-4-5-13(34(31,32)22-8-9-6-7-21-9)16(33(20,29)30)14(10)17-25-27-28-26-17/h1-5,9,21-22H,6-8H2,(H2,19,23)(H2,20,29,30)/b11-10- GFYANUUMIUZHJQ-KHPPLWFESA-N 361050 4-(2-amino-1H-benzo[d]imidazol-4-yl)-N1-(azetidin-2-ylmethyl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 207::US10544130, Example 207 Metallo-beta-lactamase type 2 0.999 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361050 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361050&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311132 386400440 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862965 C[C@H](N)CC(=O)NS(=O)(=O)c1ccc(-c2cccc3[nH]c(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C18H20N10O5S2/c1-8(19)7-13(29)26-35(32,33)12-6-5-9(10-3-2-4-11-15(10)23-18(20)22-11)14(16(12)34(21,30)31)17-24-27-28-25-17/h2-6,8H,7,19H2,1H3,(H,26,29)(H3,20,22,23)(H2,21,30,31)(H,24,25,27,28)/t8-/m0/s1 PJDYNGJJKINRRX-QMMMGPOBSA-N 361051 (S)-3-amino-N-((4-(2-amino-1H-benzo[d]imidazol-4-yl)-2-sulfamoyl-3-(2H-tetrazol-5-yl)phenyl)sulfonyl)butanamide::US10221163, Example 208::US10544130, Example 208 Metallo-beta-lactamase type 2 3.12 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361051 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361051&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124158504 386400441 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862968 Nc1ncccc1-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)N[C@@H]1CCNC1 InChI=1S/C16H19N9O4S2/c17-15-11(2-1-6-20-15)10-3-4-12(31(28,29)23-9-5-7-19-8-9)14(30(18,26)27)13(10)16-21-24-25-22-16/h1-4,6,9,19,23H,5,7-8H2,(H2,17,20)(H2,18,26,27)(H,21,22,24,25)/t9-/m1/s1 UQTMNFPUWSWOOK-SECBINFHSA-N 361052 (R)-4-(2-aminopyridin-3-yl)-N1-(pyrrolidin-3-yl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 209::US10544130, Example 209 Metallo-beta-lactamase type 2 3.10 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361052 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361052&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124158459 386400442 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862971 NCC(CN)NS(=O)(=O)c1ccc(-c2cccnc2N)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C15H20N10O4S2/c16-6-8(7-17)23-31(28,29)11-4-3-9(10-2-1-5-20-14(10)18)12(13(11)30(19,26)27)15-21-24-25-22-15/h1-5,8,23H,6-7,16-17H2,(H2,18,20)(H2,19,26,27)(H,21,22,24,25) UVVRKQCYJNZZBP-UHFFFAOYSA-N 361053 4-(2-aminopyridin- 3-yl)-N1-(1,3- diaminopropan-2- yl)-3-(2H-tetrazol-5- yl)benzene-1,2- disulfonamide::US10221163, Example 210::US10544130, Example 210 Metallo-beta-lactamase type 2 1.50 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361053 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361053&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311331 386400443 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862974 CC(C)(CN)NS(=O)(=O)c1ccc(-c2cccnc2N)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C16H21N9O4S2/c1-16(2,8-17)23-31(28,29)11-6-5-9(10-4-3-7-20-14(10)18)12(13(11)30(19,26)27)15-21-24-25-22-15/h3-7,23H,8,17H2,1-2H3,(H2,18,20)(H2,19,26,27)(H,21,22,24,25) YREYWLTWIWCHHP-UHFFFAOYSA-N 361054 N1-(1-amino-2- methylpropan-2-yl)- 4-(2-aminopyridin- 3-yl)-3-(2H- tetrazol-5- yl)benzene-1,2- disulfonamide::US10221163, Example 211::US10544130, Example 211 Metallo-beta-lactamase type 2 2.25 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361054 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361054&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311850 386400444 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862977 C[C@H](CN)NS(=O)(=O)c1ccc(-c2cccnc2N)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C15H19N9O4S2/c1-8(7-16)22-30(27,28)11-5-4-9(10-3-2-6-19-14(10)17)12(13(11)29(18,25)26)15-20-23-24-21-15/h2-6,8,22H,7,16H2,1H3,(H2,17,19)(H2,18,25,26)(H,20,21,23,24)/t8-/m1/s1 HVZNGQAYECGPHO-MRVPVSSYSA-N 361055 (R)-N1-(1-amino- propan-2-yl)-4- (2-aminopyridin-3- yl)-3-(2H- tetrazol-5- yl)benzene-1,2- disulfonamide::US10221163, Example 212::US10544130, Example 212 Metallo-beta-lactamase type 2 1.07 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361055 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361055&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135310828 386400445 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862980 NC[C@H](N)CNS(=O)(=O)c1ccc(-c2cccnc2N)c(-c2nn[nH]n2)c1S(N)(=O)=O 361056 (S)-4-(2- aminopyridin- 3-yl)-N1-(2,3- diaminopropyl)-3- (2H-tetrazol-5- yl)benzene-1,2- disulfonamide::US10221163, Example 213::US10544130, Example 213 Metallo-beta-lactamase type 2 1.54 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361056 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361056&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311376 386400446 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862983 N[C@@H](CO)CNS(=O)(=O)c1ccc(-c2cccnc2N)c(-c2nn[nH]n2)c1S(N)(=O)=O 361057 (R)-N1-(2-amino- 3-hydroxypropyl)- 4-(2-amino- pyridin-3-yl)-3- (2H-tetrazol-5- yl)benzene-1,2- disulfonamide::US10221163, Example 214::US10544130, Example 214 Metallo-beta-lactamase type 2 8.49 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361057 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361057&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311455 386400447 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862986 NC[C@H](CO)NS(=O)(=O)c1ccc(-c2cccnc2N)c(-c2nn[nH]n2)c1S(N)(=O)=O 361058 (R)-N1-(1-amino- 3-hydroxypropan- 2-yl)-4-(2- aminopyridin-3- yl)-3-(2H-tetrazol- 5-yl)benzene-1,2- disulfonamide::US10221163, Example 215::US10544130, Example 215 Metallo-beta-lactamase type 2 2.12 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361058 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361058&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311166 386400448 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862989 N[C@H]1C[C@@H]1NS(=O)(=O)c1ccc(-c2cccnc2N)c(-c2nn[nH]n2)c1S(N)(=O)=O 427274 N1-((1S)-2- aminocyclopropyl)-4- (2-aminopyridin-3-yl)- 3-(2H-tetrazol-5- yl)benzene-1,2- disulfonamide::US10544130, Example 216 Metallo-beta-lactamase type 2 1.83 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=427274 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=427274&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 148679356 434321584 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862992 Nc1ccc(cn1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)NCCc1c[nH]cn1 InChI=1S/C17H18N10O4S2/c18-14-4-1-10(7-21-14)12-2-3-13(33(30,31)23-6-5-11-8-20-9-22-11)16(32(19,28)29)15(12)17-24-26-27-25-17/h1-4,7-9,23H,5-6H2,(H2,18,21)(H,20,22)(H2,19,28,29)(H,24,25,26,27) JRUSWFUCBJJDSX-UHFFFAOYSA-N 361060 N1-(2-(1H-imidazol-4-yl)ethyl)-4-(6-aminopyridin-3-yl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 217::US10544130, Example 217 Metallo-beta-lactamase type 2 0.505 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361060 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361060&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269221 386400450 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862995 Nc1ccc(cn1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)NCCc1ncc[nH]1 InChI=1S/C17H18N10O4S2/c18-13-4-1-10(9-22-13)11-2-3-12(33(30,31)23-6-5-14-20-7-8-21-14)16(32(19,28)29)15(11)17-24-26-27-25-17/h1-4,7-9,23H,5-6H2,(H2,18,22)(H,20,21)(H2,19,28,29)(H,24,25,26,27) BLGYKMGOMSKCTK-UHFFFAOYSA-N 361061 N1-(2-(1H-imidazol-2-yl)ethyl)-4-(6-aminopyridin-3-yl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 218::US10544130, Example 218 Metallo-beta-lactamase type 2 0.694 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361061 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361061&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269222 386400451 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862998 Nc1cncc(c1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)N[C@@H]1CCNC1 427277 (R)-4-(5-aminopyridin-3-yl)-N1-(pyrrolidin-3-yl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10544130, Example 219 Metallo-beta-lactamase type 2 1.93 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=427277 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=427277&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135312000 434321587 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863001 NS(=O)(=O)c1c(ccc(-c2cccnc2N2CCNCC2)c1-c1nn[nH]n1)S(=O)(=O)N[C@@H]1CCNC1 InChI=1S/C20H26N10O4S2/c21-35(31,32)18-16(36(33,34)27-13-5-7-23-12-13)4-3-14(17(18)19-25-28-29-26-19)15-2-1-6-24-20(15)30-10-8-22-9-11-30/h1-4,6,13,22-23,27H,5,7-12H2,(H2,21,31,32)(H,25,26,28,29)/t13-/m1/s1 FXKBDOWBFUHQLK-CYBMUJFWSA-N 361063 (R)-4-(2-(piperazin-1-yl)pyridin-3-yl)-N1-(pyrrolidin-3-yl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 220::US10544130, Example 220 Metallo-beta-lactamase type 2 35.8 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361063 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361063&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135310701 386400453 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863004 C[C@H](CN)NS(=O)(=O)c1ccc(-c2cncc(N)c2)c(-c2nn[nH]n2)c1S(N)(=O)=O 361064 (R)—N1-(1-aminopropan-2-yl)-4-(5-aminopyridin-3-yl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 221::US10544130, Example 221 Metallo-beta-lactamase type 2 0.688 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361064 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361064&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135310837 386400454 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863007 NC[C@H](O)CNS(=O)(=O)c1ccc(-c2ccncc2N)c(-c2nn[nH]n2)c1S(N)(=O)=O 361065 (S)—N1-(3-amino-2-hydroxypropyl)-4-(3-aminopyridin-4-yl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 222::US10544130, Example 222 Metallo-beta-lactamase type 2 1.19 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361065 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361065&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311612 386400455 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863010 NC[C@H](N)CNS(=O)(=O)c1ccc(-c2cnccc2N)c(-c2nn[nH]n2)c1S(N)(=O)=O 361066 N4-(2-aminoethyl)-2-(2H-tetrazol-5-yl)-3'-(1H-1,2,4-triazol-3-yl)-[1,1'-biphenyl]-3,4-disulfonamide::US10221163, Example 223::US10544130, Example 223 Metallo-beta-lactamase type 2 4.51 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361066 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361066&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311691 386400456 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863013 NCCNS(=O)(=O)c1ccc(-c2cccc(c2)-c2nc[nH]n2)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C17H18N10O4S2/c18-6-7-22-33(30,31)13-5-4-12(10-2-1-3-11(8-10)16-20-9-21-23-16)14(15(13)32(19,28)29)17-24-26-27-25-17/h1-5,8-9,22H,6-7,18H2,(H2,19,28,29)(H,20,21,23)(H,24,25,26,27) HRAZYWVUQCSJIG-UHFFFAOYSA-N 361067 N4-(2-aminoethyl)-2-(2H-tetrazol-5-yl)-3′-(1H-1,2,4-triazol-3-yl)-[1,1′-biphenyl]-3,4-disulfonamide::US10221163, Example 224::US10544130, Example 224 Metallo-beta-lactamase type 2 0.412 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361067 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361067&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124158508 386400457 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863016 NS(=O)(=O)c1c(ccc(-c2cccc(c2)-c2nc[nH]n2)c1-c1nn[nH]n1)S(=O)(=O)N[C@@H]1CCNC1 InChI=1S/C19H20N10O4S2/c20-34(30,31)17-15(35(32,33)27-13-6-7-21-9-13)5-4-14(16(17)19-25-28-29-26-19)11-2-1-3-12(8-11)18-22-10-23-24-18/h1-5,8,10,13,21,27H,6-7,9H2,(H2,20,30,31)(H,22,23,24)(H,25,26,28,29)/t13-/m1/s1 QHJWADHROHWYDE-CYBMUJFWSA-N 361068 (R)-N4-(pyrrolidin-3-yl)-2-(2H- tetrazol-5-yl)-3'-(1H-1,2,4-triazol-3- yl)-[1,1'-biphenyl]-3,4-disulfonamide::US10221163, Example 225::US10544130, Example 225 Metallo-beta-lactamase type 2 0.110 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361068 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361068&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311683 386400458 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863019 N[C@@H](CO)CNS(=O)(=O)c1ccc(-c2cccc(c2)C2N=CN=N2)c(-c2nn[nH]n2)c1S(N)(=O)=O 361069 N4-((R)-2-amino-3-hydroxypropyl)- 2-(2H-tetrazol-5-yl)-3'-(3H-1,2,4- triazol-3-yl)-[1,1'-biphenyl]-3,4- disulfonamide::US10221163, Example 226::US10544130, Example 226 Metallo-beta-lactamase type 2 3.24 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361069 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361069&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311189 386400459 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863022 NCC(CN)NS(=O)(=O)c1ccc(-c2cccc(c2)-c2nc[nH]n2)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C18H21N11O4S2/c19-7-12(8-20)27-35(32,33)14-5-4-13(10-2-1-3-11(6-10)17-22-9-23-24-17)15(16(14)34(21,30)31)18-25-28-29-26-18/h1-6,9,12,27H,7-8,19-20H2,(H2,21,30,31)(H,22,23,24)(H,25,26,28,29) TVOOVNFXLKCVSE-UHFFFAOYSA-N 361070 N4-(1,3-diaminopropan-2-yl)-2- (2H-tetrazol-5-yl)-3'-(1H-1,2,4- triazol-3-yl)-[1,1'-biphenyl]-3,4- disulfonamide::US10221163, Example 227::US10544130, Example 227 Metallo-beta-lactamase type 2 0.165 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361070 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361070&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269223 386400460 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863025 NCCNS(=O)(=O)c1ccc(-c2cccc(c2)-c2n[nH]c(N)n2)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C17H19N11O4S2/c18-6-7-21-34(31,32)12-5-4-11(13(14(12)33(20,29)30)16-24-27-28-25-16)9-2-1-3-10(8-9)15-22-17(19)26-23-15/h1-5,8,21H,6-7,18H2,(H2,20,29,30)(H3,19,22,23,26)(H,24,25,27,28) TXXWCRQWLDPAJM-UHFFFAOYSA-N 361071 3'-(5-amino-1H-1,2,4-triazol-3-yl)- N4-(2-aminoethyl)-2-(2H-tetrazol-5- yl)-[1,1'-biphenyl]-3,4- disulfonamide::US10221163, Example 228::US10544130, Example 228 Metallo-beta-lactamase type 2 0.562 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361071 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361071&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269224 386400461 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863028 NCC(CN)NS(=O)(=O)c1ccc(-c2cccc(c2)C2N=NC(N)=N2)c(-c2nn[nH]n2)c1S(N)(=O)=O 361072 3'-(5-amino-3H-1,2,4-triazol-3-yl)- N4-(1,3-diaminopropan-2-yl)-2- (2H-tetrazol-5-yl)-[1,1'-biphenyl]- 3,4-disulfonamide::US10221163, Example 229::US10544130, Example 229 Metallo-beta-lactamase type 2 0.173 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361072 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361072&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311238 386400462 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863031 NC[C@@H](N)CNS(=O)(=O)c1ccc(-c2cccc(c2)-c2n[nH]c(N)n2)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C18H22N12O4S2/c19-7-11(20)8-23-36(33,34)13-5-4-12(14(15(13)35(22,31)32)17-26-29-30-27-17)9-2-1-3-10(6-9)16-24-18(21)28-25-16/h1-6,11,23H,7-8,19-20H2,(H2,22,31,32)(H3,21,24,25,28)(H,26,27,29,30)/t11-/m1/s1 HRKNTWMNDJWRNZ-LLVKDONJSA-N 361073 (R)-3'-(5-amino-1H-1,2,4-triazol-3- yl)-N4-(2,3-diaminopropyl)-2-(2H- tetrazol-5-yl)-[1,1'-biphenyl]-3,4- disulfonamide::US10221163, Example 230::US10544130, Example 230 Metallo-beta-lactamase type 2 0.357 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361073 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361073&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311364 386400463 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863034 Nc1nc(n[nH]1)-c1cccc(c1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)N[C@@H]1CCNC1 InChI=1S/C19H21N11O4S2/c20-19-23-17(24-27-19)11-3-1-2-10(8-11)13-4-5-14(36(33,34)28-12-6-7-22-9-12)16(35(21,31)32)15(13)18-25-29-30-26-18/h1-5,8,12,22,28H,6-7,9H2,(H2,21,31,32)(H3,20,23,24,27)(H,25,26,29,30)/t12-/m1/s1 IIUCDOABIKQJOU-GFCCVEGCSA-N 361074 (R)-3'-(5-amino-1H-1,2,4-triazol-3- yl)-N4-(pyrrolidin-3-yl)-2-(2H- tetrazol-5-yl)-[1,1'-biphenyl]-3,4- disulfonamide::US10221163, Example 231::US10544130, Example 231 Metallo-beta-lactamase type 2 0.376 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361074 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361074&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311825 386400464 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863037 CN1CC[C@H](C1)NS(=O)(=O)c1ccc(-c2cccc3[nH]c(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C19H20N10O4S2/c1-29-8-7-10(9-29)26-35(32,33)14-6-5-11(12-3-2-4-13-16(12)23-19(20)22-13)15(17(14)34(21,30)31)18-24-27-28-25-18/h2-6,10,26H,7-9H2,1H3,(H2,20,22)(H2,21,30,31)/b12-11+/t10-/m1/s1 QSRDUBJBQHZFPR-PJSNMCHCSA-N 361075 (R)-4-(2-amino-1H-benzo[d]imidazol-4-yl)-N1-(1-methylpyrrolidin-3-yl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 232::US10544130, Example 232 Metallo-beta-lactamase type 2 0.609 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361075 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361075&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124158391 386400465 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863040 C[N]1(C)CC[C@H](C1)NS(=O)(=O)c1ccc(-c2cccc3[nH]c(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C20H23N10O4S2/c1-30(2)9-8-11(10-30)27-36(33,34)15-7-6-12(13-4-3-5-14-17(13)24-20(21)23-14)16(18(15)35(22,31)32)19-25-28-29-26-19/h3-7,11,27H,8-10H2,1-2H3,(H2,21,23)(H2,22,31,32)/b13-12+/t11-/m1/s1 YMBSYOSFIYTLEM-GXZRWPEMSA-N 361076 (R)-3-((4-(2-amino-1H-benzo[d]imidazol-4-yl)-2-sulfamoyl-3-(2H-tetrazol-5-yl)phenyl)sulfonamido)-1,1-dimethylpyrrolidin-1-ium chloride::US10221163, Example 233::US10544130, Example 233 Metallo-beta-lactamase type 2 0.305 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361076 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361076&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311462 386400466 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863043 Nc1nc2c(cc(I)cc2[nH]1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)N[C@@H]1CCNC1 InChI=1S/C18H17IN10O4S2/c19-8-5-11(15-12(6-8)23-18(20)24-15)10-1-2-13(35(32,33)27-9-3-4-22-7-9)16(34(21,30)31)14(10)17-25-28-29-26-17/h1-2,5-6,9,22,27H,3-4,7H2,(H2,20,23)(H2,21,30,31)/b11-10+/t9-/m1/s1 OKNVYQOHMDWUOT-HNLKAFMCSA-N 361077 (R)-4-(2-amino-6-iodo-1H-benzo[d]imidazol-4-yl)-N1-(pyrrolidin-3-yl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 234::US10544130, Example 234 Metallo-beta-lactamase type 2 0.140 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361077 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361077&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124158402 386400467 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863046 NS(=O)(=O)c1c(ccc(-c2cccc3[nH]nnc23)c1-c1nn[nH]n1)S(=O)(=O)N[C@@H]1CCNC1 InChI=1S/C17H16N10O4S2/c18-32(28,29)16-13(33(30,31)24-9-6-7-19-8-9)5-4-10(14(16)17-22-26-27-23-17)11-2-1-3-12-15(11)21-25-20-12/h1-5,9,19,24H,6-8H2,(H2,18,28,29)/b11-10+/t9-/m1/s1 ARXOIEPQNDOAMQ-HNLKAFMCSA-N 361078 (R)-4-(1H-benzo[d][1,2,3]triazol-4-yl)-N1-(pyrrolidin-3-yl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 235::US10544130, Example 235 Metallo-beta-lactamase type 2 0.440 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361078 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361078&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135310991 386400468 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863049 NCCNS(=O)(=O)c1ccc(-c2cccc3[nH]nnc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C15H16N10O4S2/c16-6-7-18-31(28,29)11-5-4-8(9-2-1-3-10-13(9)20-23-19-10)12(14(11)30(17,26)27)15-21-24-25-22-15/h1-5,18H,6-7,16H2,(H2,17,26,27)(H,19,20,23)(H,21,22,24,25) QCEPJZBJONEUOB-UHFFFAOYSA-N 361079 US10221163, Example 236::US10544130, Example 236 Metallo-beta-lactamase type 2 0.544 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361079 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361079&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 137537549 386400469 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863052 C[C@H](CN)NS(=O)(=O)c1ccc(-c2cccc3[nH]nnc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C16H16N10O4S2/c1-8(7-17)23-32(29,30)12-6-5-9(10-3-2-4-11-14(10)20-24-19-11)13(15(12)31(18,27)28)16-21-25-26-22-16/h2-6,8,23H,7,17H2,1H3,(H2,18,27,28)/b10-9+/t8-/m1/s1 UGWOIILZSOTQMM-KGSKPCQNSA-N 361080 US10221163, Example 237::US10544130, Example 237 Metallo-beta-lactamase type 2 0.120 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361080 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361080&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 137537516 386400470 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863055 NS(=O)(=O)c1c(ccc(-c2cccc3nonc23)c1-c1nn[nH]n1)S(=O)(=O)N[C@@H]1CCNC1 361081 US10221163, Example 238::US10544130, Example 238 Metallo-beta-lactamase type 2 0.800 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361081 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361081&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 137537548 386400471 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863058 NCCNS(=O)(=O)c1ccc(-c2cccc3nonc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C15H15N9O5S2/c16-6-7-18-31(27,28)11-5-4-8(9-2-1-3-10-13(9)22-29-21-10)12(14(11)30(17,25)26)15-19-23-24-20-15/h1-5,18H,6-7,16H2,(H2,17,25,26)(H,19,20,23,24) PQOCNUYHZWCRFU-UHFFFAOYSA-N 361082 US10221163, Example 239::US10544130, Example 239 Metallo-beta-lactamase type 2 1.06 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361082 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361082&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 137537721 386400472 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863061 N[C@H]1CNC[C@H]1NS(=O)(=O)c1ccc(-c2cccc3[nH]c(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C18H19N11O4S2/c19-10-6-22-7-12(10)27-35(32,33)13-5-4-8(9-2-1-3-11-15(9)24-18(20)23-11)14(16(13)34(21,30)31)17-25-28-29-26-17/h1-5,10,12,22,27H,6-7,19H2,(H2,20,23)(H2,21,30,31)/b9-8+/t10-,12+/m0/s1 LIRUKQKKERNVIK-SEOINYINSA-N 361083 US10221163, Example 240::US10544130, Example 240 Metallo-beta-lactamase type 2 0.745 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361083 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361083&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 137537546 386400473 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863064 N[C@@H]1CNC[C@@H]1NS(=O)(=O)c1ccc(-c2cccc3[nH]c(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C18H19N11O4S2/c19-10-6-22-7-12(10)27-35(32,33)13-5-4-8(9-2-1-3-11-15(9)24-18(20)23-11)14(16(13)34(21,30)31)17-25-28-29-26-17/h1-5,10,12,22,27H,6-7,19H2,(H2,20,23)(H2,21,30,31)/b9-8+/t10-,12+/m1/s1 LIRUKQKKERNVIK-QMTFQVMMSA-N 361084 US10221163, Example 241::US10544130, Example 241 Metallo-beta-lactamase type 2 0.738 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361084 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361084&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311108 386400474 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863067 CNc1ccc(cn1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)N[C@@H]1CCNC1 361085 US10221163, Example 242::US10544130, Example 242 Metallo-beta-lactamase type 2 0.157 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361085 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361085&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 137537584 386400475 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863070 CNc1ccc(cn1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)NCCN InChI=1S/C15H19N9O4S2/c1-18-12-5-2-9(8-19-12)10-3-4-11(30(27,28)20-7-6-16)14(29(17,25)26)13(10)15-21-23-24-22-15/h2-5,8,20H,6-7,16H2,1H3,(H,18,19)(H2,17,25,26)(H,21,22,23,24) XAJKORAMVRKLNB-UHFFFAOYSA-N 361086 US10221163, Example 243::US10544130, Example 243 Metallo-beta-lactamase type 2 0.312 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361086 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361086&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 137537652 386400476 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863073 CN([C@H]1CCNC1)S(=O)(=O)c1ccc(-c2cccc3[nH]c(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C19H20N10O4S2/c1-29(10-7-8-22-9-10)35(32,33)14-6-5-11(12-3-2-4-13-16(12)24-19(20)23-13)15(17(14)34(21,30)31)18-25-27-28-26-18/h2-6,10,22H,7-9H2,1H3,(H2,20,23)(H2,21,30,31)/b12-11+/t10-/m0/s1 DALLWTADFKBWSD-IUZMTQGWSA-N 361087 (S)-4-(2-amino-1H-benzo[d]imidazol-7-yl)-N1-methyl-N1-(pyrrolidin-3-yl)-3-(1H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 244::US10544130, Example 244 Metallo-beta-lactamase type 2 6.58 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361087 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361087&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135149999 386400477 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863076 C[N]1(C)CC(C1)NS(=O)(=O)c1ccc(-c2cccc3[nH]c(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C19H23N10O4S2/c1-29(2)8-10(9-29)26-35(32,33)14-7-6-11(12-4-3-5-13-16(12)23-19(20)22-13)15(17(14)34(21,30)31)18-24-27-28-25-18/h3-7,10,26H,8-9H2,1-2H3,(H3,20,22,23)(H2,21,30,31)(H,24,25,27,28) ONDWABQTTHVKDD-UHFFFAOYSA-N 427409 3-(4-(2-Amino-1H-benzo[d]imidazol-4-yl)-2-sulfamoyl-3-(2H-tetrazol-5-yl)phenylsulfonamido)-1,1-dimethylazetidin-1-ium hydrogencarbonate::US10544130, Example 245 Metallo-beta-lactamase type 2 1.14 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=427409 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=427409&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311254 434317188 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863079 NCCN1CC[C@H](C1)NS(=O)(=O)c1ccc(-c2cccc3[nH]c(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C20H23N11O4S2/c21-7-9-31-8-6-11(10-31)28-37(34,35)15-5-4-12(13-2-1-3-14-17(13)25-20(22)24-14)16(18(15)36(23,32)33)19-26-29-30-27-19/h1-5,11,28H,6-10,21H2,(H2,22,24)(H2,23,32,33)/b13-12+/t11-/m1/s1 WPTXVQKWHIQZFR-GXZRWPEMSA-N 361089 (R)-4-(2-amino-1H-benzo[d]imidazol-4-yl)-N1-(1-(2-aminoethyl) pyrrolidin-3-yl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 246::US10544130, Example 246 Metallo-beta-lactamase type 2 0.853 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361089 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361089&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135310877 386400479 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863082 NCC(CO)(CO)NS(=O)(=O)c1ccc(-c2cccc3[nH]c(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C18H22N10O6S2/c19-6-18(7-29,8-30)26-36(33,34)12-5-4-9(10-2-1-3-11-14(10)23-17(20)22-11)13(15(12)35(21,31)32)16-24-27-28-25-16/h1-5,26,29-30H,6-8,19H2,(H3,20,22,23)(H2,21,31,32)(H,24,25,27,28) KTHPBOABEUUPEP-UHFFFAOYSA-N 361090 4-(2-amino-1H-benzo[d]imidazol-4-yl)-N-1-(1-amino-3-hydroxy-2-(hydroxymethyl) propan-2-yl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 247::US10544130, Example 247 Metallo-beta-lactamase type 2 0.504 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361090 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361090&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311081 386400480 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863085 C[N]1(CCN)CC[C@H](C1)NS(=O)(=O)c1ccc(-c2cccc3[nH]c(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C21H26N11O4S2/c1-32(10-8-22)9-7-12(11-32)29-38(35,36)16-6-5-13(14-3-2-4-15-18(14)26-21(23)25-15)17(19(16)37(24,33)34)20-27-30-31-28-20/h2-6,12,29H,7-11,22H2,1H3,(H2,23,25)(H2,24,33,34)/b14-13+/t12-/m1/s1 FUYNLYBAFQVTLQ-VEOJIXDASA-N 427412 (3R)-3-{[4-(2-amino-1H-1,3-benzodiazol-4-yl)-2-sulfamoyl-3-(2H-1,2,3,4-tetrazol-5-yl)benzene]sulfonamido}-1-(2-aminoethyl)-1-methylpyrrolidin-1-ium; methaneperoxoate::US10544130, Example 248 Metallo-beta-lactamase type 2 0.147 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=427412 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=427412&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124158404 434317191 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863088 C[N]1(CCN)CC[C@@H](C1)NS(=O)(=O)c1ccc(-c2cccc3[nH]c(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C21H26N11O4S2/c1-32(10-8-22)9-7-12(11-32)29-38(35,36)16-6-5-13(14-3-2-4-15-18(14)26-21(23)25-15)17(19(16)37(24,33)34)20-27-30-31-28-20/h2-6,12,29H,7-11,22H2,1H3,(H2,23,25)(H2,24,33,34)/b14-13+/t12-/m0/s1 FUYNLYBAFQVTLQ-FWJVZWRSSA-N 361091 (3R)-3-{[4-(2-amino-1H-1,3-benzodiazol-4-yl)-2-sulfamoyl-3-(2H-1,2,3,4-tetrazol-5-yl)benzene]sulfonamido}-1-(2-aminoethyl)-1-methylpyrrolidin-1-ium; methaneperoxoate::US10221163, Example 248::US10544130, Example 249 Metallo-beta-lactamase type 2 0.342 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361091 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361091&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311041 386400481 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863091 Nc1nc2c(cccc2[nH]1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)NC[C@]1(N)CCNC1 InChI=1S/C19H21N11O4S2/c20-18-25-12-3-1-2-11(15(12)26-18)10-4-5-13(36(33,34)24-9-19(21)6-7-23-8-19)16(35(22,31)32)14(10)17-27-29-30-28-17/h1-5,23-24H,6-9,21H2,(H2,20,25)(H2,22,31,32)/b11-10+/t19-/m0/s1 FHCSQKLNCSODLX-VYENPZKTSA-N 361093 (S)-4-(2-amino-1H-benzo[d]imidazol-4-yl)-N1-((3-aminopyrrolidin-3-yl)methyl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 250::US10544130, Example 250 Metallo-beta-lactamase type 2 0.513 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361093 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361093&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311019 386400483 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863094 Nc1nc2c(cccc2[nH]1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)NC[C@@]1(N)CCNC1 InChI=1S/C19H21N11O4S2/c20-18-25-12-3-1-2-11(15(12)26-18)10-4-5-13(36(33,34)24-9-19(21)6-7-23-8-19)16(35(22,31)32)14(10)17-27-29-30-28-17/h1-5,23-24H,6-9,21H2,(H2,20,25)(H2,22,31,32)/b11-10+/t19-/m1/s1 FHCSQKLNCSODLX-GNISGLHKSA-N 361094 (R)-4-(2-amino-1H-benzo[d]imidazol-4-yl)-N1-((3-aminopyrrolidin-3-yl)methyl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 251::US10544130, Example 251 Metallo-beta-lactamase type 2 0.755 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361094 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361094&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311629 386400484 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863097 Nc1nc2c(cccc2[nH]1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)NC1CNC1 InChI=1S/C17H18N10O4S2/c18-17-21-11-3-1-2-10(14(11)22-17)9-4-5-12(33(30,31)25-8-6-20-7-8)15(32(19,28)29)13(9)16-23-26-27-24-16/h1-5,8,20,25H,6-7H2,(H3,18,21,22)(H2,19,28,29)(H,23,24,26,27) CJGHWHVRPSCRKH-UHFFFAOYSA-N 361095 4-(2-amino-1H- benzo[d]imidazol-4-yl)-N1- (azetidin-3-yl)-3-(2H-tetrazol-5- yl)benzene-1,2-disulfonamide::US10221163, Example 252::US10544130, Example 252 Metallo-beta-lactamase type 2 0.654 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361095 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361095&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135310885 386400485 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863100 NC[C@H]1CCN(C1)S(=O)(=O)c1ccc(-c2cccc3[nH]c(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C19H20N10O4S2/c20-8-10-6-7-29(9-10)35(32,33)14-5-4-11(12-2-1-3-13-16(12)24-19(21)23-13)15(17(14)34(22,30)31)18-25-27-28-26-18/h1-5,10H,6-9,20H2,(H2,21,23)(H2,22,30,31)/b12-11+/t10-/m1/s1 XRAJNWIJZHZXAC-PJSNMCHCSA-N 361096 (R)-3-(2-amino-1H-benzo[d] imidazol-4-yl)-6-((3- (aminomethyl)pyrrolidin-1- yl)sulfonyl)-2-(2H-tetrazol-5- yl)benzenesulfonamide::US10221163, Example 253::US10544130, Example 253 Metallo-beta-lactamase type 2 2.68 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361096 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361096&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311473 386400486 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863103 NC[C@@H]1CCN(C1)S(=O)(=O)c1ccc(-c2cccc3[nH]c(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C19H20N10O4S2/c20-8-10-6-7-29(9-10)35(32,33)14-5-4-11(12-2-1-3-13-16(12)24-19(21)23-13)15(17(14)34(22,30)31)18-25-27-28-26-18/h1-5,10H,6-9,20H2,(H2,21,23)(H2,22,30,31)/b12-11+/t10-/m0/s1 XRAJNWIJZHZXAC-IUZMTQGWSA-N 361097 (S)-4-(2-amino-1H- benzo[d]imidazol-7-yl)-N1- methyl-N1-(pyrrolidin-3-yl)-3- (1H-tetrazol-5-yl)benzene-1,2- disulfonamide::US10221163, Example 254::US10544130, Example 254 Metallo-beta-lactamase type 2 2.13 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361097 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361097&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 137537583 386400487 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863106 CN(C1CNC1)S(=O)(=O)c1ccc(-c2cccc3[nH]c(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C18H20N10O4S2/c1-28(9-7-21-8-9)34(31,32)13-6-5-10(11-3-2-4-12-15(11)23-18(19)22-12)14(16(13)33(20,29)30)17-24-26-27-25-17/h2-6,9,21H,7-8H2,1H3,(H3,19,22,23)(H2,20,29,30)(H,24,25,26,27) YJLWZMRIPUTANI-UHFFFAOYSA-N 361098 4-(2-amino-1H- benzo[d]imidazol-4-yl)-N1- (azetidin-3-yl)-N1-methyl-3- (2H-tetrazol-5-yl)benzene-1,2- disulfonamide::US10221163, Example 255::US10544130, Example 255 Metallo-beta-lactamase type 2 2.84 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361098 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361098&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135310714 386400488 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863109 CN1CC(C1)NS(=O)(=O)c1ccc(-c2cccc3[nH]c(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C18H20N10O4S2/c1-28-7-9(8-28)25-34(31,32)13-6-5-10(11-3-2-4-12-15(11)22-18(19)21-12)14(16(13)33(20,29)30)17-23-26-27-24-17/h2-6,9,25H,7-8H2,1H3,(H3,19,21,22)(H2,20,29,30)(H,23,24,26,27) NEVMFJXLRZQHHL-UHFFFAOYSA-N 361099 4-(2-amino-1H- benzo[d]imidazol-4-yl)-N1-(1- methylazetidin-3-yl)-3-(2H- tetrazol-5-yl)benzene-1,2- disulfonamide::US10221163, Example 256::US10544130, Example 256 Metallo-beta-lactamase type 2 0.609 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361099 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361099&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135310783 386400489 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863112 CC1(CNC1)NS(=O)(=O)c1ccc(-c2cccc3[nH]c(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C18H20N10O4S2/c1-18(7-21-8-18)26-34(31,32)12-6-5-9(10-3-2-4-11-14(10)23-17(19)22-11)13(15(12)33(20,29)30)16-24-27-28-25-16/h2-6,21,26H,7-8H2,1H3,(H3,19,22,23)(H2,20,29,30)(H,24,25,27,28) YQHBXQCEAXBCEQ-UHFFFAOYSA-N 361100 4-(2-amino-1H- benzo[d]imidazol-4-yl)-N1-(3- methylazetidin-3-yl)-3-(2H- tetrazol-5-ylbenzene-1,2- disulfonamide::US10221163, Example 257::US10544130, Example 257 Metallo-beta-lactamase type 2 0.642 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361100 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361100&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135310827 386400490 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863115 NCCCCNS(=O)(=O)c1ccc(-c2cccc3[nH]c(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C18H22N10O4S2/c19-8-1-2-9-22-34(31,32)13-7-6-10(11-4-3-5-12-15(11)24-18(20)23-12)14(16(13)33(21,29)30)17-25-27-28-26-17/h3-7,22H,1-2,8-9,19H2,(H3,20,23,24)(H2,21,29,30)(H,25,26,27,28) MOMXDEZGVCWDGR-UHFFFAOYSA-N 361101 4-(2-amino-1H- benzo[d]imidazol-7-yl)-N1-(4- aminobutyl)-3-(2H-tetrazol-5- yl)benzene-1,2-disulfonamide::US10221163, Example 258::US10544130, Example 258 Metallo-beta-lactamase type 2 0.691 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361101 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361101&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135310662 386400491 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863118 Nc1nc2c(cccc2[nH]1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)NC[C@H]1CCNC1 InChI=1S/C19H20N10O4S2/c20-19-24-13-3-1-2-12(16(13)25-19)11-4-5-14(35(32,33)23-9-10-6-7-22-8-10)17(34(21,30)31)15(11)18-26-28-29-27-18/h1-5,10,22-23H,6-9H2,(H2,20,24)(H2,21,30,31)/b12-11+/t10-/m0/s1 ULQOOYRFAAKADH-IUZMTQGWSA-N 361102 (S)-4-(2-amino-1H- benzo[d]imidazol-4-yl)-N1- (pyrrolidin-3-ylmethyl)-3-(2H- tetrazol-5-yl)benzene-1,2- disulfonamide::US10221163, Example 259::US10544130, Example 259 Metallo-beta-lactamase type 2 0.836 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361102 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361102&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311424 386400492 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863121 Nc1nc2c(cccc2[nH]1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)NC1CCNCC1 InChI=1S/C19H22N10O4S2/c20-19-23-13-3-1-2-12(16(13)24-19)11-4-5-14(35(32,33)27-10-6-8-22-9-7-10)17(34(21,30)31)15(11)18-25-28-29-26-18/h1-5,10,22,27H,6-9H2,(H3,20,23,24)(H2,21,30,31)(H,25,26,28,29) YUBFCSFQTYJUHP-UHFFFAOYSA-N 361103 4-(2-amino-1H- benzo[d]imidazol-4-yl)-N1- (piperidin-4-yl)-3-(1H-tetrazol- 5-yl)benzene-1,2-disulfonamide::US10221163, Example 260::US10544130, Example 260 Metallo-beta-lactamase type 2 0.648 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361103 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361103&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135310788 386400493 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863124 Nc1nc2c(cccc2[nH]1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)NC[C@H]1CCCN1 InChI=1S/C19H20N10O4S2/c20-19-24-13-5-1-4-12(16(13)25-19)11-6-7-14(35(32,33)23-9-10-3-2-8-22-10)17(34(21,30)31)15(11)18-26-28-29-27-18/h1,4-7,10,22-23H,2-3,8-9H2,(H2,20,24)(H2,21,30,31)/b12-11+/t10-/m1/s1 IPKUSPMDIPJHQO-PJSNMCHCSA-N 361104 (R)-4-(2-amino-1H-benzo[d] imidazol-4-yl)-N1-(pyrrolidin-2- ylmethyl)-3-(2H-tetrazol-5-yl) benzene-1,2-disulfonamide::US10221163, Example 261::US10544130, Example 261 Metallo-beta-lactamase type 2 0.648 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361104 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361104&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311769 386400494 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863127 Nc1nc2c(cccc2[nH]1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)NC[C@@H]1CCCN1 InChI=1S/C19H20N10O4S2/c20-19-24-13-5-1-4-12(16(13)25-19)11-6-7-14(35(32,33)23-9-10-3-2-8-22-10)17(34(21,30)31)15(11)18-26-28-29-27-18/h1,4-7,10,22-23H,2-3,8-9H2,(H2,20,24)(H2,21,30,31)/b12-11+/t10-/m0/s1 IPKUSPMDIPJHQO-IUZMTQGWSA-N 361105 (S)-4-(2-amino-1H- benzo[d]imidazol-4-yl)-N1- (pyrrolidin-2-ylmethyl)-3-(2H- tetrazol-5-yl)benzene-1,2- disulfonamide::US10221163, Example 262::US10544130, Example 262 Metallo-beta-lactamase type 2 0.925 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361105 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361105&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135310755 386400495 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863130 Nc1nc2c(cccc2[nH]1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)NC[C@@H]1CCNC1 InChI=1S/C19H20N10O4S2/c20-19-24-13-3-1-2-12(16(13)25-19)11-4-5-14(35(32,33)23-9-10-6-7-22-8-10)17(34(21,30)31)15(11)18-26-28-29-27-18/h1-5,10,22-23H,6-9H2,(H2,20,24)(H2,21,30,31)/b12-11+/t10-/m1/s1 ULQOOYRFAAKADH-PJSNMCHCSA-N 361106 (R)-4-(2-amino-1H- benzo[d]imidazol-4-yl)-N1- (pyrrolidin-3-ylmethyl)-3-(2H- tetrazol-5-yl)benzene-1,2- disulfonamide::US10221163, Example 263::US10544130, Example 263 Metallo-beta-lactamase type 2 0.864 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361106 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361106&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135310716 386400496 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863133 CC[C@@H](CN)NS(=O)(=O)c1ccc(-c2cccc3[nH]c(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C18H20N10O4S2/c1-2-9(8-19)26-34(31,32)13-7-6-10(11-4-3-5-12-15(11)23-18(20)22-12)14(16(13)33(21,29)30)17-24-27-28-25-17/h3-7,9,26H,2,8,19H2,1H3,(H2,20,22)(H2,21,29,30)/b11-10+/t9-/m0/s1 HTZLMPQNWYVLLP-YHTNPHCKSA-N 427428 (S)-4-(2-amino-1H- benzo[d]imidazol-4-yl)-N1-(1- aminobutan-2-yl)-3-(2H- tetrazol-5-yl)benzene-1,2- disulfonamide::US10544130, Example 264 Metallo-beta-lactamase type 2 5.93 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=427428 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=427428&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 154732616 434317207 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863136 CC[C@H](CN)NS(=O)(=O)c1ccc(-c2cccc3[nH]c(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C18H20N10O4S2/c1-2-9(8-19)26-34(31,32)13-7-6-10(11-4-3-5-12-15(11)23-18(20)22-12)14(16(13)33(21,29)30)17-24-27-28-25-17/h3-7,9,26H,2,8,19H2,1H3,(H2,20,22)(H2,21,29,30)/b11-10+/t9-/m1/s1 HTZLMPQNWYVLLP-HNLKAFMCSA-N 361108 (R)-4-(2-amino-1H-benzo[d] imidazol-4-yl)-N1-(1- aminobutan-2-yl)-3-(2H- tetrazol-5-yl)benzene-1,2- disulfonamide::US10221163, Example 265::US10544130, Example 265 Metallo-beta-lactamase type 2 0.292 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361108 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361108&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311156 386400498 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863139 C[C@H](CCN)NS(=O)(=O)c1ccc(-c2cccc3[nH]c(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C18H20N10O4S2/c1-9(7-8-19)26-34(31,32)13-6-5-10(11-3-2-4-12-15(11)23-18(20)22-12)14(16(13)33(21,29)30)17-24-27-28-25-17/h2-6,9,26H,7-8,19H2,1H3,(H2,20,22)(H2,21,29,30)/b11-10+/t9-/m1/s1 TZBMGYRGFPKTLT-HNLKAFMCSA-N 361109 (R)-4-(2-amino-1H- benzo[d]imidazol-4-yl)-N1-(4- aminobutan-2-yl)-3-(2H- tetrazol-5-yl)benzene-1,2- disulfonamide::US10221163, Example 266::US10544130, Example 266 Metallo-beta-lactamase type 2 0.477 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361109 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361109&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311136 386400499 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863142 C[C@@H](CCN)NS(=O)(=O)c1ccc(-c2cccc3[nH]c(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C18H20N10O4S2/c1-9(7-8-19)26-34(31,32)13-6-5-10(11-3-2-4-12-15(11)23-18(20)22-12)14(16(13)33(21,29)30)17-24-27-28-25-17/h2-6,9,26H,7-8,19H2,1H3,(H2,20,22)(H2,21,29,30)/b11-10+/t9-/m0/s1 TZBMGYRGFPKTLT-YHTNPHCKSA-N 361110 (S)-4-(2-amino-1H- benzo[d]imidazol-4-yl)-N1-(4- aminobutan-2-yl)-3-(2H- tetrazol-5-yl)benzene-1,2- disulfonamide::US10221163, Example 267::US10544130, Example 267 Metallo-beta-lactamase type 2 1.63 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361110 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361110&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311246 386400500 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863145 NCCN1CC[C@@H](C1)NS(=O)(=O)c1ccc(-c2cccc3[nH]c(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C20H23N11O4S2/c21-7-9-31-8-6-11(10-31)28-37(34,35)15-5-4-12(13-2-1-3-14-17(13)25-20(22)24-14)16(18(15)36(23,32)33)19-26-29-30-27-19/h1-5,11,28H,6-10,21H2,(H2,22,24)(H2,23,32,33)/b13-12+/t11-/m0/s1 WPTXVQKWHIQZFR-UMAGAQSHSA-N 361111 (S)-4-(2-amino-1H- benzo[d]imidazol-4-yl)-N1-(1- (2-aminoethyl)pyrrolidin-3-yl)- 3-(2H-tetrazol-5-yl)benzene-1,2- disulfonamide::US10221163, Example 268::US10544130, Example 268 Metallo-beta-lactamase type 2 1.10 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361111 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361111&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311221 386400501 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863148 NCC(=O)NC1CCCC(=C1)c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)N[C@@H]1CCNC1 361112 2-Amino-N-(4′-(N—((R)-pyrrolidin-3-yl)sulfamoyl)-3′-sulfamoyl-2′-(2H-tetrazol-5-yl)-3,4,5,6-tetrahydro-[1,1′-biphenyl]-3-yl)acetamide::US10221163, Example 269::US10544130, Example 269 Metallo-beta-lactamase type 2 4.03 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361112 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361112&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311091 386400502 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863151 NCC(=O)NC1CCC[C@H](C1)c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)N[C@@H]1CCNC1 361113 2-Amino-N-((3R)-3-(4-(N—((R)-pyrrolidin-3-yl)sulfamoyl)-3-sulfamoyl-2-(2H-tetrazol-5-yl)phenyl)cyclohexyl)acetamide::US10221163, Example 270::US10544130, Example 270 Metallo-beta-lactamase type 2 2.32 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361113 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361113&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124158419 386400503 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863154 NC(=O)c1nc2c(cccc2[nH]1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)N[C@@H]1CCNC1 InChI=1S/C19H18N10O5S2/c20-17(30)19-23-12-3-1-2-11(15(12)24-19)10-4-5-13(36(33,34)27-9-6-7-22-8-9)16(35(21,31)32)14(10)18-25-28-29-26-18/h1-5,9,22,27H,6-8H2,(H2,20,30)(H2,21,31,32)/b11-10+/t9-/m1/s1 AIVDFIBTNMFFIT-HNLKAFMCSA-N 361114 (R)-4-(4-(N-(pyrrolidin-3-yl)sulfamoyl)-3-sulfamoyl-2-(2H-tetrazol-5-yl) phenyl)-1H-benzo[d]imidazole-2-carboxamide::US10221163, Example 271::US10544130, Example 271 Metallo-beta-lactamase type 2 0.271 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361114 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361114&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135310763 386400504 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863157 C[C@H](N)c1nc2c(cccc2[nH]1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)N[C@@H]1CCNC1 InChI=1S/C20H22N10O4S2/c1-10(21)19-24-14-4-2-3-13(17(14)25-19)12-5-6-15(36(33,34)28-11-7-8-23-9-11)18(35(22,31)32)16(12)20-26-29-30-27-20/h2-6,10-11,23,28H,7-9,21H2,1H3,(H2,22,31,32)/b13-12+/t10-,11+/m0/s1 GSTBKORRVQRJRW-MRMLYHJQSA-N 361115 4-(2-((S)-1-aminoethyl)-1H-benzo[d]imidazol-4-yl)-N1-((R)-pyrrolidin-3-yl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 272::US10544130, Example 272 Metallo-beta-lactamase type 2 1.36 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361115 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361115&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135310730 386400505 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863160 C[C@@H](N)c1nc2c(cccc2[nH]1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)N[C@@H]1CCNC1 InChI=1S/C20H22N10O4S2/c1-10(21)19-24-14-4-2-3-13(17(14)25-19)12-5-6-15(36(33,34)28-11-7-8-23-9-11)18(35(22,31)32)16(12)20-26-29-30-27-20/h2-6,10-11,23,28H,7-9,21H2,1H3,(H2,22,31,32)/b13-12+/t10-,11-/m1/s1 GSTBKORRVQRJRW-AYHAQHTHSA-N 361116 4-(2-((R)-1-aminoethyl)-1H-benzo[d]imidazol-4-yl)-N1-((R)-pyrrolidin-3-yl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 273::US10544130, Example 273 Metallo-beta-lactamase type 2 1.41 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361116 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361116&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311536 386400506 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863163 NCc1nc2cc(ccc2[nH]1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)N[C@@H]1CCNC1 InChI=1S/C19H20N10O4S2/c20-8-16-23-13-3-1-10(7-14(13)24-16)12-2-4-15(35(32,33)27-11-5-6-22-9-11)18(34(21,30)31)17(12)19-25-28-29-26-19/h1-4,7,11,22,27H,5-6,8-9,20H2,(H2,21,30,31)/b12-10+/t11-/m1/s1 DCDMYVLTGDMZLG-KPMWUXBGSA-N 361117 (R)-4-(2-(aminomethyl)-1H-benzo[d]imidazol-5-yl)-N1-(pyrrolidin-3-yl)-3-(2H -tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 274::US10544130, Example 274 Metallo-beta-lactamase type 2 0.486 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361117 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361117&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311304 386400507 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863166 NCc1nc2cc(ccc2s1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)N[C@@H]1CCNC1 361118 (R)-4-(2-(aminomethyl)benzo[d]thiazol-5-yl)-N1-(pyrrolidin-3-yl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 275::US10544130, Example 275 Metallo-beta-lactamase type 2 0.171 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361118 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361118&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135310854 386400508 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863169 NCc1nc2c(cccc2s1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)N[C@@H]1CCNC1 361119 (R)-4-(2-(aminomethyl)benzo[d]thiazol-4-yl)-N1-(pyrrolidin-3-yl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 276::US10544130, Example 276 Metallo-beta-lactamase type 2 0.542 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361119 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361119&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135310855 386400509 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863172 Nc1cccc(n1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)N[C@@H]1CCNC1 361120 (R)-4-(6-aminopyridin-2-yl)-N1-(pyrrolidin-3-yl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 277::US10544130, Example 277 Metallo-beta-lactamase type 2 1.27 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361120 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361120&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311475 386400510 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863175 NCc1ncc([nH]1)-c1cccc(c1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)N[C@@H]1CCNC1 361121 (R)-3'-(2- (aminomethyl)-1H- imidazol-5-yl)-N4- (pyrrolidin-3-yl)-2-(2H- tetrazol-5-yl)-[1,1'- biphenyl]-3,4- disulfonamide::US10221163, Example 278::US10544130, Example 278 Metallo-beta-lactamase type 2 0.640 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361121 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361121&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135310819 386400511 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863178 NCCn1nc2cccc(-c3ccc(c(c3-c3nn[nH]n3)S(N)(=O)=O)S(=O)(=O)N[C@@H]3CCNC3)c2n1 361122 (R)-4-(2-(2-aminoethyl)- 2H-benzo[d][1,2,3] triazol-4-yl)-N1- (pyrrolidin-3-yl)-3-(2H- tetrazol-5-yl)benzene- 1,2-disulfonamide::US10221163, Example 279::US10544130, Example 279 Metallo-beta-lactamase type 2 3.03 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361122 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361122&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135310729 386400512 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863181 CNc1nc2c(cccc2[nH]1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)N[C@@H]1CCNC1 InChI=1S/C19H20N10O4S2/c1-21-19-23-13-4-2-3-12(16(13)24-19)11-5-6-14(35(32,33)27-10-7-8-22-9-10)17(34(20,30)31)15(11)18-25-28-29-26-18/h2-6,10,22,27H,7-9H2,1H3,(H,21,23)(H2,20,30,31)/b12-11+/t10-/m1/s1 YATNHHPIJDKXAT-PJSNMCHCSA-N 361123 (R)-4-(2-(methylamino)- 1H-benzo[d]imidazol-4- yl)-N1-(pyrrolidin-3-yl)- 3-(2H-tetrazol-5- yl)benzene-1,2- disulfonamide::US10221163, Example 280::US10544130, Example 280 Metallo-beta-lactamase type 2 0.610 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361123 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361123&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311688 386400513 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863184 Cn1nc2cccc(-c3ccc(c(c3-c3nn[nH]n3)S(N)(=O)=O)S(=O)(=O)N[C@@H]3CCNC3)c2n1 361124 (R)-4-(2-methyl-2H- benzo[d][1,2,3]triazol-4- yl)-N1-(pyrrolidin-3-yl)- 3-(2H-tetrazol-5- yl)benzene-1,2- disulfonamide::US10221163, Example 281::US10544130, Example 281 Metallo-beta-lactamase type 2 0.750 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361124 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361124&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311110 386400514 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863187 NS(=O)(=O)c1c(ccc(-c2cnc3cc[nH]c3c2)c1-c1nn[nH]n1)S(=O)(=O)N[C@@H]1CCNC1 InChI=1S/C18H17N9O4S2/c19-32(28,29)17-15(33(30,31)25-11-3-5-20-9-11)2-1-12(16(17)18-23-26-27-24-18)10-7-14-13(22-8-10)4-6-21-14/h1-2,4,6-8,11,20,25H,3,5,9H2,(H2,19,28,29)/b12-10-/t11-/m1/s1 MMHDAOZHHVINHD-JPQYHBGPSA-N 361125 (R)-N1-(pyrrolidin-3- yl)-4-(1H-pyrrolo[3,2- b]pyridin-6-yl)-3-(2H- tetrazol-5-yl)benzene- 1,2-disulfonamide::US10221163, Example 282::US10544130, Example 282 Metallo-beta-lactamase type 2 1.13 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361125 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361125&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269225 386400515 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863190 NCc1nc2c(cccc2[nH]1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)N[C@@H]1CCNC1 InChI=1S/C19H20N10O4S2/c20-8-15-23-13-3-1-2-12(17(13)24-15)11-4-5-14(35(32,33)27-10-6-7-22-9-10)18(34(21,30)31)16(11)19-25-28-29-26-19/h1-5,10,22,27H,6-9,20H2,(H2,21,30,31)/b12-11+/t10-/m1/s1 BDHPXSZMZFSUKR-PJSNMCHCSA-N 361126 (R)-4-(2-(aminomethyl)- 1H-benzo[d]imidazol-4- yl)-N1-(pyrrolidin-3-yl)- 3-(2H-tetrazol-5- yl)benzene-1,2- disulfonamide::US10221163, Example 283::US10544130, Example 283 Metallo-beta-lactamase type 2 1.20 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361126 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361126&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269226 386400516 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863193 Nc1ncc(s1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)N[C@@H]1CCNC1 361127 (R)-4-(2-aminothiazol-5- yl)-N1-pyrrolidin-3-yl)- 3-(2H-tetrazol-5- yl)benzene-1,2- disulfonamide::US10221163, Example 284::US10544130, Example 284 Metallo-beta-lactamase type 2 0.411 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361127 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361127&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 137537699 386400517 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863196 Cc1ccc(-c2ccc(c(c2-c2nn[nH]n2)S(N)(=O)=O)S(=O)(=O)N[C@@H]2CCNC2)c2nc(N)[nH]c12 InChI=1S/C19H20N10O4S2/c1-9-2-3-12(16-15(9)23-19(20)24-16)11-4-5-13(35(32,33)27-10-6-7-22-8-10)17(34(21,30)31)14(11)18-25-28-29-26-18/h2-5,10,22,27H,6-8H2,1H3,(H2,20,23)(H2,21,30,31)/b12-11+/t10-/m1/s1 XNKOFTAOJRCAMQ-PJSNMCHCSA-N 361128 (R)-4-(2-amino-7- methyl-1H- benzo[d]imidazol-4-yl)- N1-(pyrrolidin-3-yl)-3- (2H-tetrazol-5- yl)benzene-1,2- disulfonamide::US10221163, Example 285::US10544130, Example 285 Metallo-beta-lactamase type 2 0.318 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361128 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361128&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269227 386400518 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863199 Nc1ccc2cccc(-c3ccc(c(c3-c3nn[nH]n3)S(N)(=O)=O)S(=O)(=O)N[C@@H]3CCNC3)c2n1 361129 (R)-4-(2-aminoquinolin- 8-yl)-N1-(pyrrolidin-3- yl)-3-(2H-tetrazol-5- yl)benzene-1,2- disulfonamide::US10221163, Example 286::US10544130, Example 286 Metallo-beta-lactamase type 2 0.122 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361129 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361129&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269228 386400519 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863202 NS(=O)(=O)c1c(ccc(-c2cccc3ncccc23)c1-c1nn[nH]n1)S(=O)(=O)N[C@@H]1CCNC1 361130 (R)-N1-(pyrrolidin-3- yl)-4-(quinolin-5-yl)-3- (2H-tetrazol-5- yl)benzene-1,2- disulfonamide::US10221163, Example 287::US10544130, Example 287 Metallo-beta-lactamase type 2 0.617 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361130 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361130&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269229 386400520 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863205 Nc1cc(ccn1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)N[C@@H]1CCNC1 361131 (R)-4-(2-aminopyridin- 4-yl)-N1-(pyrrolidin-3- yl)-3-(2H-tetrazol-5- yl)benzene-1,2- disulfonamide::US10221163, Example 288::US10544130, Example 288 Metallo-beta-lactamase type 2 0.462 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361131 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361131&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269230 386400521 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863208 NCCn1nnc2c(ccnc12)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)N[C@@H]1CCNC1 427453 (R)-4-(1-(2-aminoethyl)- 1H-benzo[d][1,2,3] triazol-4-yl)-N1- (pyrrolidin-3-yl)-3-(2H- tetrazol-5-yl)benzene- 1,2-disulfonamide yl)benzene-1,2- disulfonamide::US10544130, Example 289 Metallo-beta-lactamase type 2 1.22 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=427453 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=427453&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 154732618 434317231 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863211 NCc1csc(Nc2cccc(c2)-c2ccc(c(c2-c2nn[nH]n2)S(N)(=O)=O)S(=O)(=O)N[C@@H]2CCNC2)n1 361133 (R)-3'-((4- (aminomethyl)thiazol-2- yl)amino)-N4- (pyrrolidin-3-yl)-2-(2H- tetrazol-5-yl)-[1,1'- biphenyl]-3,4- disulfonamide::US10221163, Example 290::US10544130, Example 290 Metallo-beta-lactamase type 2 0.448 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361133 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361133&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269232 386400523 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863214 NS(=O)(=O)c1c(ccc(-c2cccn3ccnc23)c1-c1nn[nH]n1)S(=O)(=O)N[C@@H]1CCNC1 361134 (R)-4-(imidazo[1,2- a]pyridin-8-yl)-N1- (pyrrolidin-3-yl)-3-(2H- tetrazol-5-yl)benzene- 1,2-disulfonamide::US10221163, Example 291::US10544130, Example 291 Metallo-beta-lactamase type 2 0.169 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361134 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361134&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311135 386400524 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863217 NC(=O)c1nc2c(cccc2[nH]1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)N[C@H]1CCNC1 InChI=1S/C19H18N10O5S2/c20-17(30)19-23-12-3-1-2-11(15(12)24-19)10-4-5-13(36(33,34)27-9-6-7-22-8-9)16(35(21,31)32)14(10)18-25-28-29-26-18/h1-5,9,22,27H,6-8H2,(H2,20,30)(H2,21,31,32)/b11-10+/t9-/m0/s1 AIVDFIBTNMFFIT-YHTNPHCKSA-N 361135 (S)-4-(4-(N-(pyrrolidin-3-yl)sulfamoyl)-3-sulfamoyl-2-(2H-tetrazol-5-yl)phenyl)-1H-benzo[d]imidazole-2-carboxamide::US10221163, Example 292::US10544130, Example 292 Metallo-beta-lactamase type 2 0.672 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361135 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361135&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311276 386400525 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863220 Cn1nnc2c(cccc12)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)N[C@H]1CCNC1 361136 (S)-4-(1-methyl-1H- benzo[d][1,2,3]triazol- 4-yl)-N1-(pyrrolidin-3- yl)-3-(2H-tetrazol-5- yl)benzene-1,2- disulfonamide::US10221163, Example 293::US10544130, Example 293 Metallo-beta-lactamase type 2 1.30 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361136 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361136&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269233 386400526 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863223 Nc1nc(c[nH]1)-c1cc(ccn1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)N[C@H]1CCNC1 427458 (S)-3'-(2-amino-1H- imidazol-4-yl)-N4- (pyrrolidin-3-yl)-2-(2H- tetrazol-5-yl)-[1,1'- biphenyl]-3,4- disulfonamide::US10544130, Example 294 Metallo-beta-lactamase type 2 1.72 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=427458 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=427458&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 154732619 434317236 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863226 CNc1nc2c(cccc2[nH]1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)N[C@H]1CCNC1 InChI=1S/C19H20N10O4S2/c1-21-19-23-13-4-2-3-12(16(13)24-19)11-5-6-14(35(32,33)27-10-7-8-22-9-10)17(34(20,30)31)15(11)18-25-28-29-26-18/h2-6,10,22,27H,7-9H2,1H3,(H,21,23)(H2,20,30,31)/b12-11+/t10-/m0/s1 YATNHHPIJDKXAT-IUZMTQGWSA-N 361138 (S)-4-(2-(methylamino)- 1H-benzo[d]imidazol-4- yl)-N1-(pyrrolidin-3- yl)-3-(2H-tetrazol-5- yl)benzene-1,2- disulfonamide::US10221163, Example 295::US10544130, Example 295 Metallo-beta-lactamase type 2 0.775 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361138 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361138&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269235 386400528 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863229 N[C@H](CO)CNS(=O)(=O)c1ccc(-c2cccc3[nH]cnc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C17H17N9O5S2/c18-9(7-27)6-22-33(30,31)13-5-4-10(11-2-1-3-12-15(11)21-8-20-12)14(16(13)32(19,28)29)17-23-25-26-24-17/h1-5,8-9,22,27H,6-7,18H2,(H2,19,28,29)/b11-10+/t9-/m0/s1 DJZFNJCFCYXAQT-YHTNPHCKSA-N 361139 (S)—N1-(2-amino-3-hydroxypropyl)-4-(1H-benzo[d]imidazol-4-yl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 296::US10544130, Example 296 Metallo-beta-lactamase type 2 0.198 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361139 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361139&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135310884 386400529 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863232 N[C@H](CO)CNS(=O)(=O)c1ccc(-c2ccc(N)nc2)c(-c2nn[nH]n2)c1S(N)(=O)=O 361140 (S)—N1-(2-amino-3-hydroxypropyl)-4-(6-aminopyridin-3-yl)-3-(2H -tetrazol-5-yl) benzene-1,2-disulfonamide::US10221163, Example 297::US10544130, Example 297 Metallo-beta-lactamase type 2 0.569 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361140 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361140&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124158510 386400530 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863235 NC[C@@H](O)CNS(=O)(=O)c1ccc(-c2cccc3[nH]c(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C17H18N10O5S2/c18-6-8(28)7-21-34(31,32)12-5-4-9(10-2-1-3-11-14(10)23-17(19)22-11)13(15(12)33(20,29)30)16-24-26-27-25-16/h1-5,8,21,28H,6-7,18H2,(H2,19,22)(H2,20,29,30)/b10-9+/t8-/m1/s1 MTZJHJHGFHSZPC-KGSKPCQNSA-N 361141 (R)-4-(2-amino-1H-benzo[d]imidazol-4-yl)-N1-(3-amino-2-hydroxypropyl)-3-(2H-tetrazol-5-yl)-benzene-1,2-disulfonamide::US10221163, Example 298::US10544130, Example 298 Metallo-beta-lactamase type 2 0.671 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361141 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361141&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135310845 386400531 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863238 NC[C@@H](O)CNS(=O)(=O)c1ccc(-c2cccc3sc(CN)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O 361143 (R)—N1-(3-amino-2-hydroxypropyl)-4-(2-(aminomethyl)benzo[d]thiazol-4-yl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 300::US10544130, Example 300 Metallo-beta-lactamase type 2 2.65 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361143 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361143&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311483 386400533 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863241 NC[C@@H](O)CNS(=O)(=O)c1ccc(-c2cccc3sc(CN)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O 361143 (R)—N1-(3-amino-2-hydroxypropyl)-4-(2-(aminomethyl)benzo[d]thiazol-4-yl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 300::US10544130, Example 300 Metallo-beta-lactamase type 2 0.318 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361143 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361143&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311483 386400533 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863244 NC[C@@H](O)CNS(=O)(=O)c1ccc(-c2cccc3[nH]cnc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C17H17N9O5S2/c18-6-9(27)7-22-33(30,31)13-5-4-10(11-2-1-3-12-15(11)21-8-20-12)14(16(13)32(19,28)29)17-23-25-26-24-17/h1-5,8-9,22,27H,6-7,18H2,(H2,19,28,29)/b11-10+/t9-/m1/s1 OEBNAEHNFGQODH-HNLKAFMCSA-N 361144 (R)-4-(1H- benzo[d]imidazol-4-yl)- N1-(3-amino-2- hydroxypropyl)-3-(2H- tetrazol-5-yl)-benzene-1,2- disulfonamide::US10221163, Example 301::US10544130, Example 301 Metallo-beta-lactamase type 2 0.129 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361144 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361144&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269236 386400534 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863247 Cn1c(N)nc2c(cccc12)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)NC[C@H](O)CN 361145 (R)-4-(2-amino-1-methyl- 1H-benzo[d]imidazol-4- yl)-N1-(3-amino-2- hydroxypropyl)-3-(2H- tetrazol-5-yl)benzene-1,2- disulfonamide::US10221163, Example 302::US10544130, Example 302 Metallo-beta-lactamase type 2 0.341 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361145 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361145&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269237 386400535 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863250 NC[C@@H](O)CNS(=O)(=O)c1ccc(-c2ccc(N)nc2)c(-c2nn[nH]n2)c1S(N)(=O)=O 361146 (R)-N1-(3-amino-2- hydroxypropyl)-4-(6- aminopyridin-3-yl)-3-(2H- tetrazol-5-yl)benzene-1,2- disulfonamide::US10221163, Example 303::US10544130, Example 303 Metallo-beta-lactamase type 2 0.536 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361146 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361146&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269238 386400536 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863253 NC[C@H](O)CNS(=O)(=O)c1ccc(-c2cccc3[nH]c(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C17H18N10O5S2/c18-6-8(28)7-21-34(31,32)12-5-4-9(10-2-1-3-11-14(10)23-17(19)22-11)13(15(12)33(20,29)30)16-24-26-27-25-16/h1-5,8,21,28H,6-7,18H2,(H2,19,22)(H2,20,29,30)/b10-9+/t8-/m0/s1 MTZJHJHGFHSZPC-VPOJCXOPSA-N 361147 (S)-4-(2-amino-1H-benzo[d]imidazol-4-yl)-N1-(3-amino-2-hydroxypropyl)-3-(2H-tetrazol-5-yl)-benzene-1,2-disulfonamide::US10221163, Example 304::US10544130, Example 304 Metallo-beta-lactamase type 2 0.617 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361147 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361147&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311923 386400537 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863256 NC[C@H](O)CNS(=O)(=O)c1ccc(-c2cccc3[nH]c(CN)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C18H20N10O5S2/c19-6-9(29)8-22-35(32,33)13-5-4-10(11-2-1-3-12-16(11)24-14(7-20)23-12)15(17(13)34(21,30)31)18-25-27-28-26-18/h1-5,9,22,29H,6-8,19-20H2,(H2,21,30,31)/b11-10+/t9-/m0/s1 DNSKQBUHFYKBFQ-YHTNPHCKSA-N 361148 (S)—N1-(3-amino-2-hydroxypropyl)-4-(2-(aminomethyl)-1H-benzo[d]imidazole-4-yl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 305::US10544130, Example 305 Metallo-beta-lactamase type 2 2.06 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361148 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361148&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311272 386400538 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863259 NC[C@H](O)CNS(=O)(=O)c1ccc(-c2cccc3sc(CN)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O 361149 (S)—N1-(3-amino-2-hydroxypropyl)-4-(2-(aminom ethyl) benzo[d]thiazol-4-yl)-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 306::US10544130, Example 306 Metallo-beta-lactamase type 2 0.293 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361149 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361149&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135310723 386400539 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863262 NC[C@H](O)CNS(=O)(=O)c1ccc(-c2cccc3[nH]cnc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C17H17N9O5S2/c18-6-9(27)7-22-33(30,31)13-5-4-10(11-2-1-3-12-15(11)21-8-20-12)14(16(13)32(19,28)29)17-23-25-26-24-17/h1-5,8-9,22,27H,6-7,18H2,(H2,19,28,29)/b11-10+/t9-/m0/s1 OEBNAEHNFGQODH-YHTNPHCKSA-N 361150 (S)-4-(1H- benzo[d]imidazol-4-yl)- N1-(3-amino-2- hydroxypropyl)-3-(2H- tetrazol-5-yl)-benzene- 1,2-disulfonamide::US10221163, Example 307::US10544130, Example 307 Metallo-beta-lactamase type 2 0.258 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361150 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361150&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269239 386400540 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863265 Cn1c(N)nc2c(cccc12)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)NC[C@@H](O)CN 361151 (S)-4-(2-amino-1-methyl- 1H-benzo[d]imidazol-4- yl)-N1-(3-amino-2- hydroxypropyl)-3-(2H- tetrazol-5-yl)benzene- 1,2-disulfonamide::US10221163, Example 308::US10544130, Example 308 Metallo-beta-lactamase type 2 0.403 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361151 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361151&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269240 386400541 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863268 NC[C@H](O)CNS(=O)(=O)c1ccc(-c2ccc(N)nc2)c(-c2nn[nH]n2)c1S(N)(=O)=O 361152 (S)-N1-(3-amino-2- hydroxypropyl)-4-(6- aminopyridin-3-yl)-3- (2H-tetrazol-5- yl)benzene-1,2- disulfonamide::US10221163, Example 309::US10544130, Example 309 Metallo-beta-lactamase type 2 0.501 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361152 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361152&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269241 386400542 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863271 Nc1nc2c(cccc2[nH]1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)NC[C@@H]1CNCCN1 InChI=1S/C19H21N11O4S2/c20-19-25-13-3-1-2-12(16(13)26-19)11-4-5-14(36(33,34)24-9-10-8-22-6-7-23-10)17(35(21,31)32)15(11)18-27-29-30-28-18/h1-5,10,22-24H,6-9H2,(H2,20,25)(H2,21,31,32)/b12-11+/t10-/m0/s1 AUAQCWDTNCWURJ-IUZMTQGWSA-N 361153 (S)-4-(2-amino-1H-benzo[d]imidazol-4-yl)-N1-(piperazin-2-ylmethyl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 310::US10544130, Example 310 Metallo-beta-lactamase type 2 0.667 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361153 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361153&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311308 386400543 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863274 NCc1nc2c(cccc2[nH]1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)NC[C@@H]1CNCCN1 InChI=1S/C20H23N11O4S2/c21-8-16-26-14-3-1-2-13(18(14)27-16)12-4-5-15(37(34,35)25-10-11-9-23-6-7-24-11)19(36(22,32)33)17(12)20-28-30-31-29-20/h1-5,11,23-25H,6-10,21H2,(H2,22,32,33)/b13-12+/t11-/m0/s1 GUTSCMUGLOXWCV-UMAGAQSHSA-N 427475 (S)-4-(2-(aminomethyl)-1H-benzo[d]imidazol-4-yl)-N-(piperazin-2-ylmethyl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10544130, Example 311 Metallo-beta-lactamase type 2 1.27 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=427475 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=427475&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135310849 434317251 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863277 Nc1ccc(cn1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)NC[C@@H]1CNCCN1 361155 (S)-4-(6- aminopyridin-3- yl)-N1-(piperazin- 2-ylmethyl)-3-(2H- tetrazol-5- yl)benzene-1,2- disulfonamide::US10221163, Example 312::US10544130, Example 312 Metallo-beta-lactamase type 2 0.586 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361155 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361155&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269242 386400545 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863280 Nc1ncccc1-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)NC[C@@H]1CNCCN1 361156 (S)-4-(2- aminopyridin-3- yl)-N1-(piperazin- 2-ylmethyl)-3-(2H- tetrazol-5- yl)benzene-1,2- disulfonamide::US10221163, Example 313::US10544130, Example 313 Metallo-beta-lactamase type 2 1.30 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361156 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361156&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269243 386400546 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863283 Nc1nc2c(cccc2[nH]1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)NC[C@H]1CNCCN1 InChI=1S/C19H21N11O4S2/c20-19-25-13-3-1-2-12(16(13)26-19)11-4-5-14(36(33,34)24-9-10-8-22-6-7-23-10)17(35(21,31)32)15(11)18-27-29-30-28-18/h1-5,10,22-24H,6-9H2,(H2,20,25)(H2,21,31,32)/b12-11+/t10-/m1/s1 AUAQCWDTNCWURJ-PJSNMCHCSA-N 361157 (R)-4-(2-amino-1H-benzo[d]imidazol-4-yl)-N1-(piperazin-2-ylmethyl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 314::US10544130, Example 314 Metallo-beta-lactamase type 2 0.485 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361157 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361157&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124158409 386400547 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863286 Nc1ccc(cn1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)NC[C@H]1CNCCN1 361158 (R)-4-(6- aminopyridin-3- yl)-N1-(piperazin- 2-ylmethyl)-3- (1H-tetrazol-5- yl)benzene-1,2- disulfonamide::US10221163, Example 315::US10544130, Example 315 Metallo-beta-lactamase type 2 0.459 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361158 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361158&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269244 386400548 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863289 Nc1ncccc1-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)NC[C@H]1CNCCN1 361159 (R)-4-(2- aminopyridin-3- yl)-N1-(piperazin- 2-ylmethyl)-3- (1H-tetrazol-5- yl)benzene-1,2- disulfonamide::US10221163, Example 316::US10544130, Example 316 Metallo-beta-lactamase type 2 2.33 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361159 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361159&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269245 386400549 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863292 C[C@H](CN)NS(=O)(=O)c1ccc(-c2ccnc(N)c2)c(-c2nn[nH]n2)c1S(N)(=O)=O 361160 (R)—N1-(1-aminopropan-2-yl)-4-(2-aminopyridin-4-yl)-3-(2H -tetrazol-5-yl) benzene-1,2-disulfonamide::US10221163, Example 317::US10544130, Example 317 Metallo-beta-lactamase type 2 0.495 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361160 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361160&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135310749 386400550 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863295 C[C@H](CN)NS(=O)(=O)c1ccc(-c2cccc(N)n2)c(-c2nn[nH]n2)c1S(N)(=O)=O 361161 (R)—N1-(1-aminopropan-2-yl)-4-(6-aminopyridin-2-yl)-3-(2H-tetrazol-5-yl) benzene-1,2-disulfonamide::US10221163, Example 318::US10544130, Example 318 Metallo-beta-lactamase type 2 0.704 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361161 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361161&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311448 386400551 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863298 N[C@H]1CNC[C@H]1NS(=O)(=O)c1ccc(-c2cccc3ccc(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O 361162 N1-((3R,4S)-4-aminopyrrolidin-3-yl)-4-(2-aminoquinolin-8-yl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 319::US10544130, Example 319 Metallo-beta-lactamase type 2 0.265 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361162 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361162&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 137537600 386400552 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863301 N[C@H]1CNC[C@H]1NS(=O)(=O)c1ccc(-c2cnc3cc[nH]c3c2)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C18H18N10O4S2/c19-11-7-21-8-14(11)26-34(31,32)15-2-1-10(9-5-13-12(23-6-9)3-4-22-13)16(17(15)33(20,29)30)18-24-27-28-25-18/h1-6,11,14,21,26H,7-8,19H2,(H2,20,29,30)/b10-9-/t11-,14+/m0/s1 AVDOWAXKOVDGSF-GEQRGXFDSA-N 361163 N1-((3R,4S)-4-aminopyrrolidin-3-yl)-4-(1H-pyrrolo[3,2-b]pyridin-6-yl-3-(2H -tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 320::US10544130, Example 320 Metallo-beta-lactamase type 2 1.21 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361163 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361163&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311118 386400553 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863304 N[C@H]1CNC[C@H]1NS(=O)(=O)c1ccc(-c2cnc(N)s2)c(-c2nn[nH]n2)c1S(N)(=O)=O 361164 N1-((3R,4S)-4-aminopyrrolidin-3-yl)-4-(2-aminothiazol-5-yl)-3-(2H -tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 321::US10544130, Example 321 Metallo-beta-lactamase type 2 1.25 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361164 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361164&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135310993 386400554 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863307 N[C@@H]1CNC[C@H]1NS(=O)(=O)c1ccc(-c2cccc3[nH]c(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C18H19N11O4S2/c19-10-6-22-7-12(10)27-35(32,33)13-5-4-8(9-2-1-3-11-15(9)24-18(20)23-11)14(16(13)34(21,30)31)17-25-28-29-26-17/h1-5,10,12,22,27H,6-7,19H2,(H2,20,23)(H2,21,30,31)/b9-8+/t10-,12-/m1/s1 LIRUKQKKERNVIK-VCXMCINHSA-N 361165 4-(2-Amino-1H-benzo[d]imidazol-4-yl)-N1-((3S,4R)-4-aminopyrrolidin-3-yl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 322::US10221163, Example 424::US10544130, Example 424 Metallo-beta-lactamase type 2 0.738 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361165 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361165&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269246 386400555 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863310 N[C@H](CO)c1nc2c(cccc2[nH]1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)N[C@H]1CNC[C@H]1N InChI=1S/C20H23N11O5S2/c21-11-6-24-7-14(11)29-38(35,36)15-5-4-9(16(18(15)37(23,33)34)20-27-30-31-28-20)10-2-1-3-13-17(10)26-19(25-13)12(22)8-32/h1-5,11-12,14,24,29,32H,6-8,21-22H2,(H2,23,33,34)/b10-9+/t11-,12-,14+/m1/s1 RMSQROZEJIGAKY-WMAAAFJKSA-N 361166 4-(2-((S)-1-amino-2-hydroxyethyl)-1H-benzo[d]imidazol-4-yl)-N1-((3S,4R)-4-aminopyrrolidin-3-yl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 323::US10544130, Example 323 Metallo-beta-lactamase type 2 3.39 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361166 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361166&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269247 386400556 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863313 N[C@@H]1CNC[C@@H]1NS(=O)(=O)c1ccc(-c2cccc3ccc(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O 361167 N1-((3S,4R)-4- aminopyrrolidin-3-yl)-4- (2-aminoquinolin-8-yl)- 3-(1H-tetrazol-5- yl)benzene-1,2- disulfonamide::US10221163, Example 324::US10544130, Example 324 Metallo-beta-lactamase type 2 0.213 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361167 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361167&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269248 386400557 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863316 N[C@@H]1CNC[C@@H]1NS(=O)(=O)c1ccc(-c2cnc(N)s2)c(-c2nn[nH]n2)c1S(N)(=O)=O 361168 N1-((3S,4R)-4- aminopyrrolidin-3-yl)-4- (2-aminothiazol-5-yl)-3- (2H-tetrazol-5- yl)benzene-1,2- disulfonamide::US10221163, Example 325::US10544130, Example 325 Metallo-beta-lactamase type 2 1.22 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361168 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361168&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311358 386400558 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863319 N[C@@H]1CNC[C@@H]1NS(=O)(=O)c1ccc(-c2cnc3cc[nH]c3c2)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C18H18N10O4S2/c19-11-7-21-8-14(11)26-34(31,32)15-2-1-10(9-5-13-12(23-6-9)3-4-22-13)16(17(15)33(20,29)30)18-24-27-28-25-18/h1-6,11,14,21,26H,7-8,19H2,(H2,20,29,30)/b10-9-/t11-,14+/m1/s1 AVDOWAXKOVDGSF-VTSTVKRSSA-N 361169 N1-((3S,4R)-4- aminopyrrolidin-3-yl)-4- (1H-pyrrolo[3,2- b]pyridin-6-yl)-3-(2H- tetrazol-5-yl)benzene- 1,2-disulfonamide::US10221163, Example 326::US10544130, Example 326 Metallo-beta-lactamase type 2 0.650 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361169 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361169&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269249 386400559 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863322 N[C@@H]1CNC[C@@H]1NS(=O)(=O)c1ccc(-c2cccc(c2)-c2c[nH]c(N)n2)c(-c2nn[nH]n2)c1S(N)(=O)=O 361170 3'-(2-amino-1H-imidazol- 4-yl)-N4-((3S,4R)-4- aminopyrrolidin-3-yl)-2- (2H-tetrazol-5-yl)-[1,1'- biphenyl]-3,4- disulfonamide::US10221163, Example 327::US10544130, Example 327 Metallo-beta-lactamase type 2 1.41 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361170 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361170&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269250 386400560 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863325 N[C@@H]1CNC[C@@H]1NS(=O)(=O)c1ccc(-c2cccn3ccnc23)c(-c2nn[nH]n2)c1S(N)(=O)=O 361171 N1-((3S,4R)-4- aminopyrrolidin-3-yl)-4- (imidazo[1,2-a]pyridin-8- yl)-3-(2H-tetrazol-5- yl)benzene-1,2- disulfonamide::US10221163, Example 328::US10544130, Example 328 Metallo-beta-lactamase type 2 0.340 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361171 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361171&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311487 386400561 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863328 Cc1ccc(-c2ccc(c(c2-c2nn[nH]n2)S(N)(=O)=O)S(=O)(=O)NCCN)c2nc(N)[nH]c12 InChI=1S/C17H20N10O4S2/c1-8-2-3-10(14-13(8)22-17(19)23-14)9-4-5-11(33(30,31)21-7-6-18)15(32(20,28)29)12(9)16-24-26-27-25-16/h2-5,21H,6-7,18H2,1H3,(H3,19,22,23)(H2,20,28,29)(H,24,25,26,27) RQPNOZBYGYYABS-UHFFFAOYSA-N 361172 4-(2-Amino-7-methyl-1H-benzo[d]imidazol-4-yl)-N1-(2-aminoethyl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 329::US10544130, Example 329 Metallo-beta-lactamase type 2 0.128 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361172 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361172&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269251 386400562 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862347 Nc1nc2cccc(-c3ccc(c(c3-c3nn[nH]n3)S(N)(=O)=O)S(N)(=O)=O)c2[nH]1 InChI=1S/C14H13N9O4S2/c15-14-18-8-3-1-2-7(11(8)19-14)6-4-5-9(28(16,24)25)12(29(17,26)27)10(6)13-20-22-23-21-13/h1-5H,(H3,15,18,19)(H2,16,24,25)(H2,17,26,27)(H,20,21,22,23) VVGDNPGVZIEQAP-UHFFFAOYSA-N 360338 4-(2-amino-3H-benzo[d]imidazol-4-yl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 1::US10544130, Example 1 Metallo-beta-lactamase type 2 0.581 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360338 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360338&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124159584 386399745 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862350 Nc1ccc2cccc(-c3ccc(c(c3-c3nn[nH]n3)S(N)(=O)=O)S(N)(=O)=O)c2n1 InChI=1S/C16H14N8O4S2/c17-12-7-4-8-2-1-3-10(14(8)20-12)9-5-6-11(29(18,25)26)15(30(19,27)28)13(9)16-21-23-24-22-16/h1-7H,(H2,17,20)(H2,18,25,26)(H2,19,27,28)(H,21,22,23,24) VDGZDOXAAFBKEX-UHFFFAOYSA-N 360345 4-(2-aminoquinolin-8-yl)-3- (2H-tetrazol-5-yl)benzene- 1,2-disulfonamide::US10221163, Example 2::US10544130, Example 2 Metallo-beta-lactamase type 2 0.279 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360345 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360345&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311171 386399752 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862353 NS(=O)(=O)c1ccc(-c2cccc3cn[nH]c23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C14H12N8O4S2/c15-27(23,24)10-5-4-8(9-3-1-2-7-6-17-18-12(7)9)11(13(10)28(16,25)26)14-19-21-22-20-14/h1-6H,(H,17,18)(H2,15,23,24)(H2,16,25,26)(H,19,20,21,22) LITRKXUVXQDMIS-UHFFFAOYSA-N 360363 4-(1H-indazol-7-yl)-3-(2H- tetrazol-5-yl)benzene-1,2- disulfonamide::US10221163, Example 3::US10221163, Example 7::US10544130, Example 3 Metallo-beta-lactamase type 2 0.233 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360363 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360363&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311274 386399767 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862356 Nc1nc2c(cccc2o1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(N)(=O)=O InChI=1S/C14H12N8O5S2/c15-14-18-11-7(2-1-3-8(11)27-14)6-4-5-9(28(16,23)24)12(29(17,25)26)10(6)13-19-21-22-20-13/h1-5H,(H2,15,18)(H2,16,23,24)(H2,17,25,26)(H,19,20,21,22) XSWVMWMRFVXDMM-UHFFFAOYSA-N 360848 4-(2-aminobenzo[d]oxazol- 4-yl)-3-(2H-tetrazol-5- yl)benzene-1,2- disulfonamide::US10221163, Example 4::US10544130, Example 4 Metallo-beta-lactamase type 2 0.354 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360848 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360848&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311043 386400242 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862359 Cn1c(N)nc2c(cccc12)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(N)(=O)=O InChI=1S/C15H15N9O4S2/c1-24-9-4-2-3-8(12(9)19-15(24)16)7-5-6-10(29(17,25)26)13(30(18,27)28)11(7)14-20-22-23-21-14/h2-6H,1H3,(H2,16,19)(H2,17,25,26)(H2,18,27,28)(H,20,21,22,23) DHHOUQGEQFJXDP-UHFFFAOYSA-N 360849 4-(2-amino-1-methyl-1H- benzo[d]imidazol-4-yl)-3- (2H-tetrazol-5-yl)benzene- 1,2-disulfonamide::US10221163, Example 5::US10544130, Example 5 Metallo-beta-lactamase type 2 0.346 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360849 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360849&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135310692 386400243 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862362 Cc1ccc(-c2ccc(c(c2-c2nn[nH]n2)S(N)(=O)=O)S(N)(=O)=O)c2nc(N)sc12 InChI=1S/C15H14N8O4S3/c1-6-2-3-8(11-12(6)28-15(16)19-11)7-4-5-9(29(17,24)25)13(30(18,26)27)10(7)14-20-22-23-21-14/h2-5H,1H3,(H2,16,19)(H2,17,24,25)(H2,18,26,27)(H,20,21,22,23) CRWZLJNNDOWHSX-UHFFFAOYSA-N 360850 4-(2-amino-7- methylbenzo[d]thiazol-4-yl)- 3-(2H-tetrazol-5-yl)benzene- 1,2-disulfonamide::US10221163, Example 6::US10544130, Example 6 Metallo-beta-lactamase type 2 0.065 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360850 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360850&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311034 386400244 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862365 CNS(=O)(=O)c1ccc(-c2cccc3cn[nH]c23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C15H14N8O4S2/c1-17-29(26,27)11-6-5-9(10-4-2-3-8-7-18-19-13(8)10)12(14(11)28(16,24)25)15-20-22-23-21-15/h2-7,17H,1H3,(H,18,19)(H2,16,24,25)(H,20,21,22,23) XLRPXJWNTZKRLK-UHFFFAOYSA-N 427052 4-(1H-indazol-7-yl)-N1- methyl-3-(2H-tetrazol-5- yl)benzene-1,2- disulfonamide::US10544130, Example 7 Metallo-beta-lactamase type 2 0.214 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=427052 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=427052&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135310992 434321369 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862368 NS(=O)(=O)c1ccc(-c2cccc3[nH]c(nc23)C(O)=O)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C15H12N8O6S2/c16-30(26,27)9-5-4-6(10(12(9)31(17,28)29)13-20-22-23-21-13)7-2-1-3-8-11(7)19-14(18-8)15(24)25/h1-5H,(H,18,19)(H,24,25)(H2,16,26,27)(H2,17,28,29)(H,20,21,22,23) PHSIHADDWCLCLE-UHFFFAOYSA-N 360852 4-(3,4-disulfamoyl-2-(2H-tetrazol-5-yl)phenyl)-1H-benzo[d]imidazole-2-carboxylic acid::US10221163, Example 8::US10544130, Example 8 Metallo-beta-lactamase type 2 0.361 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360852 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360852&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124159700 386400245 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862371 NCCNS(=O)(=O)c1ccc(-c2cccc3cn[nH]c23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C16H17N9O4S2/c17-6-7-20-31(28,29)12-5-4-10(11-3-1-2-9-8-19-21-14(9)11)13(15(12)30(18,26)27)16-22-24-25-23-16/h1-5,8,20H,6-7,17H2,(H,19,21)(H2,18,26,27)(H,22,23,24,25) CWJKRRQBAPFZIH-UHFFFAOYSA-N 360853 N1-(2-aminoethyl)-4-(1H-indazol-7-yl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 9::US10544130, Example 9 Metallo-beta-lactamase type 2 0.171 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360853 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360853&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124158388 386400246 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862374 Cn1c(N)nc2c(cccc12)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)NCCN InChI=1S/C17H20N10O4S2/c1-27-11-4-2-3-10(14(11)22-17(27)19)9-5-6-12(33(30,31)21-8-7-18)15(32(20,28)29)13(9)16-23-25-26-24-16/h2-6,21H,7-8,18H2,1H3,(H2,19,22)(H2,20,28,29)(H,23,24,25,26) MIAXLWJVTIMZHF-UHFFFAOYSA-N 360854 4-(2-amino-1-methyl-1H- benzo[d]imidazol-4-yl)- N1-(2-aminoethyl)-3-(2H- tetrazol-5-yl)benzene-1,2- disulfonamide hydrochloride::US10221163, Example 10::US10544130, Example 10 Metallo-beta-lactamase type 2 0.235 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360854 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360854&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311847 386400247 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862377 Nc1c(cccc1B(O)O)C#N InChI=1S/C7H7BN2O2/c9-4-5-2-1-3-6(7(5)10)8(11)12/h1-3,11-12H,10H2 HCBQCTAFMHAHIT-UHFFFAOYSA-N 367839 (2-amino-3- cyanophenyl) boronic acid::US10227331, Example 26::US10544130, Example 11 Metallo-beta-lactamase type 2 0.105 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367839 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367839&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 67038879 402364699 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862380 OB(O)c1cccc2[nH]cnc12 InChI=1S/C7H7BN2O2/c11-8(12)5-2-1-3-6-7(5)10-4-9-6/h1-4,11-12H,(H,9,10) UNWJCMBQRPPTIH-UHFFFAOYSA-N 367841 (1H- benzo[d]imidazol- 4-yl)boronic acid::US10227331, Example 28::US10544130, Example 12 Metallo-beta-lactamase type 2 0.316 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=367841 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=367841&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 45077856 402364701 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862383 NCCNS(=O)(=O)c1ccc(-c2cccc3oc(nc23)C(O)=O)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C17H16N8O7S2/c18-6-7-20-34(30,31)11-5-4-8(12(14(11)33(19,28)29)15-22-24-25-23-15)9-2-1-3-10-13(9)21-16(32-10)17(26)27/h1-5,20H,6-7,18H2,(H,26,27)(H2,19,28,29)(H,22,23,24,25) JTQVEIOPHVMFAR-UHFFFAOYSA-N 360857 4-(4-(N-(2-aminoethyl)sulfamoyl)-3-sulfamoyl-2-(2H-tetrazol-5-yl)phenyl)benzo[d]oxazole-2-carboxylic acid::US10221163, Example 13::US10544130, Example 13 Metallo-beta-lactamase type 2 2.14 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360857 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360857&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124159659 386400250 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862386 Nc1nc2c(cccc2s1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)NC1CCS(=O)(=O)CC1 InChI=1S/C19H20N8O6S4/c20-19-22-16-12(2-1-3-13(16)34-19)11-4-5-14(17(36(21,30)31)15(11)18-23-26-27-24-18)37(32,33)25-10-6-8-35(28,29)9-7-10/h1-5,10,25H,6-9H2,(H2,20,22)(H2,21,30,31)(H,23,24,26,27) NJNPJGQDAFDHTB-UHFFFAOYSA-N 360858 4-(2-amino-1,3- benzothiazol-4-yl)-N1- (1,1-dioxidotetrahydro-2H- thiopyran-4-yl)-3-(1H- tetrazol-5-yl)benzene-1,2- disulfonamide::US10221163, Example 14::US10544130, Example 14 Metallo-beta-lactamase type 2 0.173 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360858 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360858&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135310908 386400251 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862389 Nc1nc2c(cccc2s1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)NCCN1CCNC(=O)C1 InChI=1S/C20H22N10O5S3/c21-20-25-17-12(2-1-3-13(17)36-20)11-4-5-14(18(37(22,32)33)16(11)19-26-28-29-27-19)38(34,35)24-7-9-30-8-6-23-15(31)10-30/h1-5,24H,6-10H2,(H2,21,25)(H,23,31)(H2,22,32,33)(H,26,27,28,29) IQVSMXLKXITUHA-UHFFFAOYSA-N 360859 4-(2-amino-1,3- benzothiazol-4-yl)-N1-[2- (3-oxopiperazin-1- yl)ethyl]-3-(1H-tetrazol-5- yl)benzene-1,2- disulfonamide::US10221163, Example 15::US10544130, Example 15 Metallo-beta-lactamase type 2 0.451 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360859 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360859&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311346 386400252 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862392 CN(C)CC(F)(F)CNS(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nnn[nH]2)c1S(N)(=O)=O InChI=1S/C19H21F2N9O4S3/c1-30(2)9-19(20,21)8-24-37(33,34)13-7-6-10(11-4-3-5-12-15(11)25-18(22)35-12)14(16(13)36(23,31)32)17-26-28-29-27-17/h3-7,24H,8-9H2,1-2H3,(H2,22,25)(H2,23,31,32)(H,26,27,28,29) UXNGUTOGQXUODT-UHFFFAOYSA-N 360860 4-(2-amino-1,3- benzothiazol-4-yl)-N1-[3- (dimethylamino)-2,2- difluoropropyl]-3-(1H- tetrazol-5-yl)benzene-1,2- disulfonamide::US10221163, Example 16::US10544130, Example 16 Metallo-beta-lactamase type 2 0.442 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360860 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360860&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311248 386400253 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862395 CN1CCOC(CNS(=O)(=O)c2ccc(-c3cccc4sc(N)nc34)c(-c3nnn[nH]3)c2S(N)(=O)=O)C1 360861 4-(2-amino-1,3- benzothiazol-4-yl)-N1-[(4- methylmorpholin-2- yl)methyl]-3-(1H-tetrazol- 5-yl)benzene-1,2- disulfonamide::US10221163, Example 17::US10544130, Example 17 Metallo-beta-lactamase type 2 0.430 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360861 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360861&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311518 386400254 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862398 CN1CCCC(C1)NS(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nnn[nH]2)c1S(N)(=O)=O 360862 4-(2-amino-1,3- benzothiazol-4-yl)-N1-(1- methylpiperidin-3-yl)-3- (1H-tetrazol-5-yl)benzene- 1,2-disulfonamide::US10221163, Example 18::US10544130, Example 18 Metallo-beta-lactamase type 2 0.268 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360862 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360862&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311014 386400255 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862401 Nc1nc2c(cccc2s1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)NCC1CCC(=O)N1 360863 4-(2-amino-1,3- benzothiazol-4-yl)-N1-[(5- oxopyrrolidin-2- yl)methyl]-3-(1H-tetrazol- 5-yl)benzene-1,2- disulfonamide::US10221163, Example 19::US10544130, Example 19 Metallo-beta-lactamase type 2 0.486 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360863 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360863&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135310834 386400256 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862404 Cn1cnc(CNS(=O)(=O)c2ccc(-c3cccc4sc(N)nc34)c(-c3nnn[nH]3)c2S(N)(=O)=O)n1 InChI=1S/C18H17N11O4S3/c1-29-8-21-13(26-29)7-22-36(32,33)12-6-5-9(10-3-2-4-11-15(10)23-18(19)34-11)14(16(12)35(20,30)31)17-24-27-28-25-17/h2-6,8,22H,7H2,1H3,(H2,19,23)(H2,20,30,31)(H,24,25,27,28) KQHJVFYEQCPAAB-UHFFFAOYSA-N 360864 4-(2-amino-1,3- benzothiazol-4-yl)-N1-[(1- methyl-1H-1,2,4-triazol-3- yl)methyl]-3-(1H-tetrazol- 5-yl)benzene-1,2- disulfonamide::US10221163, Example 20::US10544130, Example 20 Metallo-beta-lactamase type 2 0.817 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360864 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360864&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311339 386400257 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862407 Nc1nc2c(cccc2s1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)NCCN1CCC1 InChI=1S/C19H21N9O4S3/c20-19-23-16-12(3-1-4-13(16)33-19)11-5-6-14(35(31,32)22-7-10-28-8-2-9-28)17(34(21,29)30)15(11)18-24-26-27-25-18/h1,3-6,22H,2,7-10H2,(H2,20,23)(H2,21,29,30)(H,24,25,26,27) ZOIGAFIIRTZXOR-UHFFFAOYSA-N 360865 4-(2-amino-1,3- benzothiazol-4-yl)-N1-(2- azetidin-1-ylethyl)-3-(1H- tetrazol-5-yl)benzene-1,2- disulfonamide::US10221163, Example 21::US10544130, Example 21 Metallo-beta-lactamase type 2 0.383 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360865 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360865&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135310717 386400258 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863331 NCCNS(=O)(=O)c1ccc(-c2cccc3[nH]c(nc23)[C@H](N)CO)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C18H20N10O5S2/c19-6-7-22-35(32,33)13-5-4-9(14(16(13)34(21,30)31)18-25-27-28-26-18)10-2-1-3-12-15(10)24-17(23-12)11(20)8-29/h1-5,11,22,29H,6-8,19-20H2,(H2,21,30,31)/b10-9+/t11-/m1/s1 TXRDLFRTEYNPJV-PBQZMEPESA-N 361173 (S)-4-(2-(1-amino-2-hydroxyethyl)-1H-benzo[d]imidazol-4-yl)-N1-(2-aminoethyl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 330::US10544130, Example 330 Metallo-beta-lactamase type 2 2.76 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361173 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361173&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269252 386400563 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863334 NCCNS(=O)(=O)c1ccc(-c2cccc3[nH]c(nc23)[C@@H](N)CO)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C18H20N10O5S2/c19-6-7-22-35(32,33)13-5-4-9(14(16(13)34(21,30)31)18-25-27-28-26-18)10-2-1-3-12-15(10)24-17(23-12)11(20)8-29/h1-5,11,22,29H,6-8,19-20H2,(H2,21,30,31)/b10-9+/t11-/m0/s1 TXRDLFRTEYNPJV-USKTWTLRSA-N 361174 (R)-4-(2-(1-amino-2-hydroxyethyl)-1H-benzo[d] imidazol-4-yl)-N1-(2-aminoethyl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 331::US10544130, Example 331 Metallo-beta-lactamase type 2 2.28 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361174 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361174&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269253 386400564 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863337 NCCNS(=O)(=O)c1ccc(-c2cccc(C(=O)NC[C@@H](N)CO)c2N)c(-c2nn[nH]n2)c1S(N)(=O)=O 361175 (R)-2-amino-N-(2-amino-3-hydroxypropyl)-4′-(N-(2-aminoethyl)sulfamoyl)-3′-sulfamoyl-2′-(2H-tetrazol-5-yl-[1,1′-biphenyl]-3-carboxamide::US10221163, Example 332::US10544130, Example 332 Metallo-beta-lactamase type 2 3.00 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361175 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361175&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269254 386400565 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863340 NCCNS(=O)(=O)c1ccc(-c2cccc(C(=O)NC[C@H](N)CO)c2N)c(-c2nn[nH]n2)c1S(N)(=O)=O 361176 (S)-2-amino-N-(2-amino-3-hydroxypropyl)-4′-(N-(2-aminoethyl)sulfamoyl)-3′-sulfamoyl-2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-3-carboxamide::US10221163, Example 333::US10544130, Example 333 Metallo-beta-lactamase type 2 3.21 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361176 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361176&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269255 386400566 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863343 NCCNC(=O)c1cccc(c1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)NCCN InChI=1S/C18H23N9O5S2/c19-6-8-22-18(28)12-3-1-2-11(10-12)13-4-5-14(34(31,32)23-9-7-20)16(33(21,29)30)15(13)17-24-26-27-25-17/h1-5,10,23H,6-9,19-20H2,(H,22,28)(H2,21,29,30)(H,24,25,26,27) QPZMHHDLQNWPAO-UHFFFAOYSA-N 361177 N-(2-aminoethyl)-4′-(N-(2-aminoethyl)sulfamoyl)-3′-sulfamoyl-2′-(2H -tetrazol-5-yl)-[1,1′-biphenyl]-3-carboxamide::US10221163, Example 334::US10544130, Example 334 Metallo-beta-lactamase type 2 4.60 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361177 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361177&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269256 386400567 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863346 NCCNS(=O)(=O)c1ccc(-c2cccc3[nH]c(nc23)[C@H](N)CN)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C18H21N11O4S2/c19-6-7-23-35(32,33)13-5-4-9(14(16(13)34(22,30)31)18-26-28-29-27-18)10-2-1-3-12-15(10)25-17(24-12)11(21)8-20/h1-5,11,23H,6-8,19-21H2,(H2,22,30,31)/b10-9+/t11-/m1/s1 NLRLVEZYFRBSKE-PBQZMEPESA-N 361178 (R)—N1-(2-aminoethyl)-4-(2-(1,2-diaminoethyl)-1H-benzo[d]imidazole-4-yl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 335::US10544130, Example 335 Metallo-beta-lactamase type 2 4.78 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361178 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361178&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269257 386400568 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863349 NCCNS(=O)(=O)c1ccc(-c2cccc3[nH]c(nc23)[C@@H](N)CN)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C18H21N11O4S2/c19-6-7-23-35(32,33)13-5-4-9(14(16(13)34(22,30)31)18-26-28-29-27-18)10-2-1-3-12-15(10)25-17(24-12)11(21)8-20/h1-5,11,23H,6-8,19-21H2,(H2,22,30,31)/b10-9+/t11-/m0/s1 NLRLVEZYFRBSKE-USKTWTLRSA-N 361179 (S)—N1-(2-aminoethyl)-4-(2-(1,2-diaminoethyl)-1H-benzo[d]imidazol-4-yl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 336::US10544130, Example 336 Metallo-beta-lactamase type 2 2.90 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361179 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361179&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269258 386400569 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863352 NCCNS(=O)(=O)c1ccc(-c2cccc3[nH]c(CCN)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C18H22N10O4S2/c19-7-6-14-23-12-3-1-2-11(16(12)24-14)10-4-5-13(34(31,32)22-9-8-20)17(33(21,29)30)15(10)18-25-27-28-26-18/h1-5,22H,6-9,19-20H2,(H,23,24)(H2,21,29,30)(H,25,26,27,28) UITXDZUIOMRDEF-UHFFFAOYSA-N 361180 N1-(2-aminoethyl)-4-(2-(2-aminoethyl)-1H-benzo[d]imidazol-4-yl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 337::US10544130, Example 337 Metallo-beta-lactamase type 2 2.23 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361180 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361180&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269259 386400570 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863355 NCCNS(=O)(=O)c1ccc(C2=CC(N)CCC2)c(-c2nn[nH]n2)c1S(N)(=O)=O 361181 5′-Amino-N4-(2-aminoethyl)-2-(2H-tetrazol-5-yl)-2′,3′,4′,5′-tetrahydro-[1,1′-biphenyl]-3,4-disulfonamide::US10221163, Example 338::US10544130, Example 338 Metallo-beta-lactamase type 2 91.0 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361181 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361181&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124158414 386400571 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863358 N[C@H]1CCCC(=C1)c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)N[C@@H]1CCNC1 InChI=1S/C17H24N8O4S2/c18-11-3-1-2-10(8-11)13-4-5-14(31(28,29)23-12-6-7-20-9-12)16(30(19,26)27)15(13)17-21-24-25-22-17/h4-5,8,11-12,20,23H,1-3,6-7,9,18H2,(H2,19,26,27)(H,21,22,24,25)/t11-,12+/m0/s1 IMWXDQXYXIFOOQ-NWDGAFQWSA-N 361183 (S)-5′-amino-N4-((R)-pyrrolidin-3-yl)-2-(2H-tetrazol-5-yl)-2′,3′,4′,5′-tetrahydro-[1,1′-biphenyl]-3,4-disulfonamide::US10221163, Example 340::US10544130, Example 340 Metallo-beta-lactamase type 2 34.1 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361183 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361183&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124158270 386400573 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863361 N[C@H]1CCCC(=C1)c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)N[C@@H]1CCNC1 InChI=1S/C17H24N8O4S2/c18-11-3-1-2-10(8-11)13-4-5-14(31(28,29)23-12-6-7-20-9-12)16(30(19,26)27)15(13)17-21-24-25-22-17/h4-5,8,11-12,20,23H,1-3,6-7,9,18H2,(H2,19,26,27)(H,21,22,24,25)/t11-,12+/m0/s1 IMWXDQXYXIFOOQ-NWDGAFQWSA-N 361183 (S)-5′-amino-N4-((R)-pyrrolidin-3-yl)-2-(2H-tetrazol-5-yl)-2′,3′,4′,5′-tetrahydro-[1,1′-biphenyl]-3,4-disulfonamide::US10221163, Example 340::US10544130, Example 340 Metallo-beta-lactamase type 2 46.7 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361183 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361183&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124158270 386400573 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863364 NCCCNC(=O)c1cccc(c1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)NCCN InChI=1S/C19H25N9O5S2/c20-7-2-9-23-19(29)13-4-1-3-12(11-13)14-5-6-15(35(32,33)24-10-8-21)17(34(22,30)31)16(14)18-25-27-28-26-18/h1,3-6,11,24H,2,7-10,20-21H2,(H,23,29)(H2,22,30,31)(H,25,26,27,28) CHZMHLGFIPQNHF-UHFFFAOYSA-N 361184 4′-(N-(2-aminoethyl)sulfamoyl)-N-(3-aminopropyl)-3′-sulfamoyl-2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-3-carboxamide::US10221163, Example 341::US10544130, Example 341 Metallo-beta-lactamase type 2 4.13 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361184 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361184&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269260 386400574 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863367 NCCNS(=O)(=O)c1ccc(C2CCC[C@H](N)C2)c(-c2nn[nH]n2)c1S(N)(=O)=O 361185 4-((3S)-3-aminocyclohexyl)-N1-(2-aminoethyl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 342::US10544130, Example 342 Metallo-beta-lactamase type 2 88.7 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361185 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361185&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124158348 386400575 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863370 NCCNS(=O)(=O)c1ccc(-c2cccc3[nH]c(CN)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C17H20N10O4S2/c18-6-7-21-33(30,31)12-5-4-9(10-2-1-3-11-15(10)23-13(8-19)22-11)14(16(12)32(20,28)29)17-24-26-27-25-17/h1-5,21H,6-8,18-19H2,(H,22,23)(H2,20,28,29)(H,24,25,26,27) WEEQPBCMGHANSA-UHFFFAOYSA-N 361186 N1-(2-aminoethyl)-4-(2-(aminomethyl)-1H-benzo[d]imidazol-4-yl-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 343::US10544130, Example 343 Metallo-beta-lactamase type 2 1.37 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361186 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361186&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135310772 386400576 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863373 NCCNS(=O)(=O)c1ccc(-c2cccc(c2)C(=O)N[C@@H]2CNC[C@H]2O)c(-c2nn[nH]n2)c1S(N)(=O)=O 361187 4′-(N-(2-aminoethyl)sulfamoyl)-N-((3R,4R)-4-hydroxypyrrolidin-3-yl)-3′-sulfamoyl-2′-(2H-tetrazol-5-yl-[1,1′-biphenyl]-3-carboxamide::US10221163, Example 344::US10544130, Example 344 Metallo-beta-lactamase type 2 4.26 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361187 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361187&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124158227 386400577 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863376 NCCNS(=O)(=O)c1ccc(-c2cccc3sc(CN)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C17H19N9O4S3/c18-6-7-21-33(29,30)12-5-4-9(10-2-1-3-11-15(10)22-13(8-19)31-11)14(16(12)32(20,27)28)17-23-25-26-24-17/h1-5,21H,6-8,18-19H2,(H2,20,27,28)(H,23,24,25,26) MDKTUBIZBKMCTP-UHFFFAOYSA-N 361188 N1-(2-aminoethyl)-4-(2-(aminomethyl)benzo[d]thiazol-4-yl)-3-(2H -tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 345::US10544130, Example 345 Metallo-beta-lactamase type 2 0.676 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361188 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361188&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311461 386400578 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863379 NCCNS(=O)(=O)c1ccc(-c2cccc(c2)C(=O)NC[C@H](O)CN)c(-c2nn[nH]n2)c1S(N)(=O)=O 361189 (R)—N-(3-amino-2-hydroxypropyl)-4′-(N-(2-aminoethyl)sulfamoyl)-3′-sulfamoyl-2′-(2H-tetrazol-5-yl-[1,1′-biphenyl]-3-carboxamide::US10221163, Example 346::US10221163, Example 347::US10544130, Example 347 Metallo-beta-lactamase type 2 3.65 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361189 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361189&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311707 386400579 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863382 NCCNS(=O)(=O)c1ccc(-c2cccc(c2)C(=O)NC[C@H](O)CN)c(-c2nn[nH]n2)c1S(N)(=O)=O 361189 (R)—N-(3-amino-2-hydroxypropyl)-4′-(N-(2-aminoethyl)sulfamoyl)-3′-sulfamoyl-2′-(2H-tetrazol-5-yl-[1,1′-biphenyl]-3-carboxamide::US10221163, Example 346::US10221163, Example 347::US10544130, Example 347 Metallo-beta-lactamase type 2 3.97 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361189 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361189&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311707 386400579 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863385 NCCNS(=O)(=O)c1ccc(-c2ccc3ncn(CCN)c3c2)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C18H22N10O4S2/c19-5-7-23-34(31,32)15-4-2-12(16(17(15)33(21,29)30)18-24-26-27-25-18)11-1-3-13-14(9-11)28(8-6-20)10-22-13/h1-4,9-10,23H,5-8,19-20H2,(H2,21,29,30)(H,24,25,26,27) NUGIVIRZGIFIKC-UHFFFAOYSA-N 361191 N1-(2-aminoethyl)-4-(1-(2-aminoethyl)-1H-benzo[d]imidazol-6-yl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 348::US10544130, Example 348 Metallo-beta-lactamase type 2 3.33 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361191 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361191&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311029 386400580 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863388 NCCNS(=O)(=O)c1ccc(-c2cccc(NC[C@@H](N)CO)c2)c(-c2nn[nH]n2)c1S(N)(=O)=O 361192 (R)-3'-((2-amino-3- hydroxypropyl) amino)-N4-(2- aminoethyl)-2-(2H- tetrazol-5-yl)-[1,1'- biphenyl]-3,4- disulfonamide::US10221163, Example 349::US10544130, Example 349 Metallo-beta-lactamase type 2 5.65 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361192 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361192&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269261 386400581 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862410 CN(C)CCNS(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nnn[nH]2)c1S(N)(=O)=O InChI=1S/C18H21N9O4S3/c1-27(2)9-8-21-34(30,31)13-7-6-10(11-4-3-5-12-15(11)22-18(19)32-12)14(16(13)33(20,28)29)17-23-25-26-24-17/h3-7,21H,8-9H2,1-2H3,(H2,19,22)(H2,20,28,29)(H,23,24,25,26) BZSYHKGTTGQSDN-UHFFFAOYSA-N 360866 4-(2-amino-1,3- benzothiazol-4-yl)-N1-[2- (dimethylamino)ethyl]-3- (1H-tetrazol-5-yl)benzene- 1,2-disulfonamide::US10221163, Example 22::US10544130, Example 22 Metallo-beta-lactamase type 2 0.413 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360866 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360866&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135310721 386400259 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862413 CNC(=O)CNS(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nnn[nH]2)c1S(N)(=O)=O InChI=1S/C17H17N9O5S3/c1-20-12(27)7-21-34(30,31)11-6-5-8(9-3-2-4-10-14(9)22-17(18)32-10)13(15(11)33(19,28)29)16-23-25-26-24-16/h2-6,21H,7H2,1H3,(H2,18,22)(H,20,27)(H2,19,28,29)(H,23,24,25,26) MWQOZPQHEVVWNU-UHFFFAOYSA-N 360867 N2-{[4-(2-amino-1,3- benzothiazol-4-yl)-2- sulfamoyl-3-(1H-tetrazol- 5-yl)phenyl]sulfonyl}-N- methylglycinamide::US10221163, Example 23::US10544130, Example 23 Metallo-beta-lactamase type 2 0.294 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360867 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360867&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311692 386400260 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862416 COCCNS(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nnn[nH]2)c1S(N)(=O)=O InChI=1S/C17H18N8O5S3/c1-30-8-7-20-33(28,29)12-6-5-9(10-3-2-4-11-14(10)21-17(18)31-11)13(15(12)32(19,26)27)16-22-24-25-23-16/h2-6,20H,7-8H2,1H3,(H2,18,21)(H2,19,26,27)(H,22,23,24,25) LNXPRASRSVXUTN-UHFFFAOYSA-N 360868 4-(2-amino-1,3- benzothiazol-4-yl)-N1-(2- methoxyethyl)-3-(1H- tetrazol-5-yl)benzene-1,2- disulfonamide::US10221163, Example 24::US10544130, Example 24 Metallo-beta-lactamase type 2 0.235 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360868 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360868&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311150 386400261 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862419 Nc1nc2c(cccc2s1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)N1CCC(CO)CC1 InChI=1S/C20H22N8O5S3/c21-20-23-17-13(2-1-3-14(17)34-20)12-4-5-15(36(32,33)28-8-6-11(10-29)7-9-28)18(35(22,30)31)16(12)19-24-26-27-25-19/h1-5,11,29H,6-10H2,(H2,21,23)(H2,22,30,31)(H,24,25,26,27) PZZILJUFSUVPJQ-UHFFFAOYSA-N 360869 3-(2-amino-1,3- benzothiazol-4-yl)-6-{[4- (hydroxymethyl)piperidin- 1-yl]sulfonyl}-2-(1H- tetrazol-5- yl)benzenesulfonamide::US10221163, Example 25::US10544130, Example 25 Metallo-beta-lactamase type 2 2.24 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360869 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360869&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311719 386400262 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862422 CN(C)C1CCN(CC1)S(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nnn[nH]2)c1S(N)(=O)=O InChI=1S/C21H25N9O4S3/c1-29(2)12-8-10-30(11-9-12)37(33,34)16-7-6-13(14-4-3-5-15-18(14)24-21(22)35-15)17(19(16)36(23,31)32)20-25-27-28-26-20/h3-7,12H,8-11H2,1-2H3,(H2,22,24)(H2,23,31,32)(H,25,26,27,28) QDKKWLLPLUZTAW-UHFFFAOYSA-N 360870 3-(2-amino-1,3- benzothiazol-4-yl)-6-{[4- (dimethylamino)piperidin- 1-yl]sulfonyl}-2-(1H- tetrazol-5- yl)benzenesulfonamide::US10221163, Example 26::US10544130, Example 26 Metallo-beta-lactamase type 2 1.15 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360870 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360870&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311538 386400263 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862425 CN1CCN(CC1)S(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nnn[nH]2)c1S(N)(=O)=O InChI=1S/C19H21N9O4S3/c1-27-7-9-28(10-8-27)35(31,32)14-6-5-11(12-3-2-4-13-16(12)22-19(20)33-13)15(17(14)34(21,29)30)18-23-25-26-24-18/h2-6H,7-10H2,1H3,(H2,20,22)(H2,21,29,30)(H,23,24,25,26) UTQRORGNZQVVQY-UHFFFAOYSA-N 360871 3-(2-amino-1,3- benzothiazol-4-yl)-6-[(4- methylpiperazin-1- yl)sulfonyl]-2-(1H- tetrazol-5- yl)benzenesulfonamide::US10221163, Example 27::US10544130, Example 27 Metallo-beta-lactamase type 2 1.59 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360871 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360871&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135310976 386400264 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862428 Nc1nc2c(cccc2s1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)N1CCNC(=O)C1 InChI=1S/C18H17N9O5S3/c19-18-22-15-10(2-1-3-11(15)33-18)9-4-5-12(35(31,32)27-7-6-21-13(28)8-27)16(34(20,29)30)14(9)17-23-25-26-24-17/h1-5H,6-8H2,(H2,19,22)(H,21,28)(H2,20,29,30)(H,23,24,25,26) GLBQLNGOYWLSPB-UHFFFAOYSA-N 360872 3-(2-amino-1,3- benzothiazol-4-yl)-6-[(3- oxopiperazin-1- yl)sulfonyl]-2-(1H- tetrazol-5- yl)benzenesulfonamide::US10221163, Example 28::US10544130, Example 28 Metallo-beta-lactamase type 2 0.646 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360872 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360872&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311875 386400265 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862431 Nc1nc2c(cccc2s1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)N1CCOCC1 InChI=1S/C18H18N8O5S3/c19-18-21-15-11(2-1-3-12(15)32-18)10-4-5-13(34(29,30)26-6-8-31-9-7-26)16(33(20,27)28)14(10)17-22-24-25-23-17/h1-5H,6-9H2,(H2,19,21)(H2,20,27,28)(H,22,23,24,25) ZVAPKOHBUPNLTN-UHFFFAOYSA-N 360873 3-(2-amino-1,3- benzothiazol-4-yl)-6- (morpholin-4-ylsulfonyl)- 2-(1H-tetrazol-5- yl)benzenesulfonamide::US10221163, Example 29::US10544130, Example 29 Metallo-beta-lactamase type 2 2.08 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360873 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360873&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311547 386400266 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862434 Nc1nc2c(cccc2s1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)NCCC1CNC1 InChI=1S/C19H21N9O4S3/c20-19-24-16-12(2-1-3-13(16)33-19)11-4-5-14(35(31,32)23-7-6-10-8-22-9-10)17(34(21,29)30)15(11)18-25-27-28-26-18/h1-5,10,22-23H,6-9H2,(H2,20,24)(H2,21,29,30)(H,25,26,27,28) IZVFPCAFESKVCW-UHFFFAOYSA-N 360874 4-(2-amino-1,3- benzothiazol-4-yl)-N1-(2- azetidin-3-ylethyl)-3-(1H- tetrazol-5-yl)benzene-1,2- disulfonamide::US10221163, Example 30::US10544130, Example 30 Metallo-beta-lactamase type 2 0.369 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360874 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360874&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311463 386400267 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862437 CNCCNS(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nnn[nH]2)c1S(N)(=O)=O InChI=1S/C17H19N9O4S3/c1-20-7-8-21-33(29,30)12-6-5-9(10-3-2-4-11-14(10)22-17(18)31-11)13(15(12)32(19,27)28)16-23-25-26-24-16/h2-6,20-21H,7-8H2,1H3,(H2,18,22)(H2,19,27,28)(H,23,24,25,26) OUKQBVXVFXQAKN-UHFFFAOYSA-N 360875 4-(2-amino-1,3- benzothiazol-4-yl)-N1-[2- (methylamino)ethyl]-3- (1H-tetrazol-5-yl)benzene- 1,2-disulfonamide::US10221163, Example 31::US10544130, Example 31 Metallo-beta-lactamase type 2 2.02 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360875 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360875&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311051 386400268 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862440 Nc1nc2c(cccc2s1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)NC1CCNCC1 InChI=1S/C19H21N9O4S3/c20-19-23-16-12(2-1-3-13(16)33-19)11-4-5-14(35(31,32)26-10-6-8-22-9-7-10)17(34(21,29)30)15(11)18-24-27-28-25-18/h1-5,10,22,26H,6-9H2,(H2,20,23)(H2,21,29,30)(H,24,25,27,28) MQPNMUKUHJVESA-UHFFFAOYSA-N 360876 4-(2-amino-1,3- benzothiazol-4-yl)-N1- piperidin-4-yl-3-(1H- tetrazol-5-yl)benzene-1,2- disulfonamide::US10221163, Example 32::US10544130, Example 32 Metallo-beta-lactamase type 2 0.340 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360876 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360876&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311486 386400269 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862443 Nc1nc2c(cccc2s1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)NCCN1CCCCC1=O InChI=1S/C21H23N9O5S3/c22-21-25-18-13(4-3-5-14(18)36-21)12-7-8-15(19(37(23,32)33)17(12)20-26-28-29-27-20)38(34,35)24-9-11-30-10-2-1-6-16(30)31/h3-5,7-8,24H,1-2,6,9-11H2,(H2,22,25)(H2,23,32,33)(H,26,27,28,29) DTEHDBCPEXVDDP-UHFFFAOYSA-N 360877 4-(2-amino-1,3- benzothiazol-4-yl)-N1-[2- (2-oxopiperidin-1- yl)ethyl]-3-(1H-tetrazol-5- yl)benzene-1,2- disulfonamide::US10221163, Example 33::US10544130, Example 33 Metallo-beta-lactamase type 2 0.275 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360877 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360877&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311383 386400270 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862446 COc1ccnc(CNS(=O)(=O)c2ccc(-c3cccc4sc(N)nc34)c(-c3nnn[nH]3)c2S(N)(=O)=O)n1 InChI=1S/C20H18N10O5S3/c1-35-15-7-8-23-14(25-15)9-24-38(33,34)13-6-5-10(11-3-2-4-12-17(11)26-20(21)36-12)16(18(13)37(22,31)32)19-27-29-30-28-19/h2-8,24H,9H2,1H3,(H2,21,26)(H2,22,31,32)(H,27,28,29,30) OEDGFHOVDDKFPY-UHFFFAOYSA-N 360878 4-(2-amino-1,3- benzothiazol-4-yl)-N1-[(4- methoxypyrimidin-2- yl)methyl]-3-(1H-tetrazol- 5-yl)benzene-1,2- disulfonamide::US10221163, Example 34::US10544130, Example 34 Metallo-beta-lactamase type 2 0.429 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360878 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360878&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269188 386400271 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862449 Nc1nc2c(cccc2s1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)NC1CCc2nccn2C1 360879 4-(2-amino-1,3- benzothiazol-4-yl)-N1- (5,6,7,8- tetrahydroimidazo[1,2- a]pyridin-6-yl)-3-(1H- tetrazol-5-yl)benzene-1,2- disulfonamide::US10221163, Example 35::US10544130, Example 35 Metallo-beta-lactamase type 2 0.349 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360879 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360879&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269189 386400272 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862452 CN(C)C(=O)CNS(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nnn[nH]2)c1S(N)(=O)=O InChI=1S/C18H19N9O5S3/c1-27(2)13(28)8-21-35(31,32)12-7-6-9(10-4-3-5-11-15(10)22-18(19)33-11)14(16(12)34(20,29)30)17-23-25-26-24-17/h3-7,21H,8H2,1-2H3,(H2,19,22)(H2,20,29,30)(H,23,24,25,26) REQDHYOMMZXOKJ-UHFFFAOYSA-N 360880 N2-{[4-(2-amino-1,3- benzothiazol-4-yl)-2- sulfamoyl-3-(1H-tetrazol- 5-yl)phenyl]sulfonyl}- N,N-dimethylglycinamide::US10221163, Example 36::US10544130, Example 36 Metallo-beta-lactamase type 2 0.247 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360880&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135310645 386400273 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862455 Nc1nc2c(cccc2s1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)NCC1(CO)CC1 InChI=1S/C19H20N8O5S3/c20-18-23-15-11(2-1-3-12(15)33-18)10-4-5-13(35(31,32)22-8-19(9-28)6-7-19)16(34(21,29)30)14(10)17-24-26-27-25-17/h1-5,22,28H,6-9H2,(H2,20,23)(H2,21,29,30)(H,24,25,26,27) JKXPEBYUPDCQQP-UHFFFAOYSA-N 360881 4-(2-amino-1,3- benzothiazol-4-yl)-N1-{[1- (hydroxymethyl)cyclopropyl] methyl}-3-(1H-tetrazol- 5-yl)benzene-1,2- disulfonamide::US10221163, Example 37::US10544130, Example 37 Metallo-beta-lactamase type 2 0.287 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360881 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360881&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311488 386400274 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862458 CN1CC2(C1)CCN(C2)S(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nnn[nH]2)c1S(N)(=O)=O InChI=1S/C21H23N9O4S3/c1-29-9-21(10-29)7-8-30(11-21)37(33,34)15-6-5-12(13-3-2-4-14-17(13)24-20(22)35-14)16(18(15)36(23,31)32)19-25-27-28-26-19/h2-6H,7-11H2,1H3,(H2,22,24)(H2,23,31,32)(H,25,26,27,28) MWPLZFTURBIIPM-UHFFFAOYSA-N 360882 3-(2-amino-1,3- benzothiazol-4-yl)-6-[(2- methyl-2,6- diazaspiro[3.4]oct-6- yl)sulfonyl]-2-(1H- tetrazol-5- yl)benzenesulfonamide::US10221163, Example 38::US10544130, Example 38 Metallo-beta-lactamase type 2 1.43 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360882 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360882&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311496 386400275 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862461 CN(C)C1CN(C1)S(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nnn[nH]2)c1S(N)(=O)=O InChI=1S/C19H21N9O4S3/c1-27(2)10-8-28(9-10)35(31,32)14-7-6-11(12-4-3-5-13-16(12)22-19(20)33-13)15(17(14)34(21,29)30)18-23-25-26-24-18/h3-7,10H,8-9H2,1-2H3,(H2,20,22)(H2,21,29,30)(H,23,24,25,26) FSBJMTPSCUKYHG-UHFFFAOYSA-N 360883 3-(2-amino-1,3- benzothiazol-4-yl)-6-{[3- (dimethylamino)azetidin- 1-yl]sulfonyl}-2-(1H- tetrazol-5- yl)benzenesulfonamide::US10221163, Example 39::US10544130, Example 39 Metallo-beta-lactamase type 2 0.878 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360883 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360883&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311445 386400276 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862464 Nc1nc2c(cccc2s1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)N1CC2CC1CS2(=O)=O 360884 3-(2-amino-1,3- benzothiazol-4-yl)-6-[(2,2- dioxido-2-thia-5- azabicyclo[2.2.1]hept-5- yl)sulfonyl]-2-(1H- tetrazol-5- yl)benzenesulfonamide::US10221163, Example 40::US10544130, Example 40 Metallo-beta-lactamase type 2 1.86 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360884 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360884&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135310752 386400277 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862467 CN(C1CCS(=O)(=O)C1)S(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nnn[nH]2)c1S(N)(=O)=O 360885 4-(2-amino-1,3- benzothiazol-4-yl)-N1-(1,1- dioxidotetrahydrothiophen- 3-yl)-N~1~-methyl-3-(1H- tetrazol-5-yl)benzene-1,2- disulfonamide::US10221163, Example 41::US10544130, Example 41 Metallo-beta-lactamase type 2 0.810 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360885 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360885&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 137537637 386400278 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862470 Nc1nc2c(cccc2s1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)N1CC(F)(F)C1 InChI=1S/C17H14F2N8O4S3/c18-17(19)6-27(7-17)34(30,31)11-5-4-8(9-2-1-3-10-13(9)22-16(20)32-10)12(14(11)33(21,28)29)15-23-25-26-24-15/h1-5H,6-7H2,(H2,20,22)(H2,21,28,29)(H,23,24,25,26) QFYYYMBQAPXZRF-UHFFFAOYSA-N 360886 3-(2-amino-1,3- benzothiazol-4-yl)-6-[(3,3- difluoroazetidin-1- yl)sulfonyl]-2-(1H- tetrazol-5- yl)benzenesulfonamide::US10221163, Example 42::US10544130, Example 42 Metallo-beta-lactamase type 2 0.700 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360886 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360886&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135310984 386400279 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863391 NCCNS(=O)(=O)c1ccc(-c2cccc(NC[C@H](N)CO)c2)c(-c2nn[nH]n2)c1S(N)(=O)=O 361193 (S)-3'-((2-amino-3- hydroxypropyl) amino)-N4-(2- aminoethyl)-2-(2H- tetrazol-5-yl)-[1,1'- biphenyl]-3,4- disulfonamide::US10221163, Example 350::US10544130, Example 350 Metallo-beta-lactamase type 2 4.40 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361193 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361193&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269262 386400582 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863394 NCCNS(=O)(=O)c1ccc(-c2cccc(NC[C@H](O)CN)c2)c(-c2nn[nH]n2)c1S(N)(=O)=O 361194 (R)-3'-((3-amino-2- hydroxypropyl) amino)-N4-(2- aminoethyl)-2-(2H- tetrazol-5-yl)-[1,1'- biphenyl]-3,4- disulfonamide::US10221163, Example 351::US10544130, Example 351 Metallo-beta-lactamase type 2 3.55 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361194 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361194&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269263 386400583 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863397 NCCNS(=O)(=O)c1ccc(-c2cccc(NC[C@@H](O)CN)c2)c(-c2nn[nH]n2)c1S(N)(=O)=O 361195 (S)-3'-((3-amino-2- hydroxypropyl) amino)N4-(2- aminoethyl)-2-(2H- tetrazol-5-yl)-[1,1'- biphenyl]-3,4- disulfonamide::US10221163, Example 352::US10544130, Example 352 Metallo-beta-lactamase type 2 4.39 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361195 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361195&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269264 386400584 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863400 NCCNS(=O)(=O)c1ccc(-c2cccc(c2)-c2c[nH]c(N)n2)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C18H20N10O4S2/c19-6-7-23-34(31,32)14-5-4-12(15(16(14)33(21,29)30)17-25-27-28-26-17)10-2-1-3-11(8-10)13-9-22-18(20)24-13/h1-5,8-9,23H,6-7,19H2,(H3,20,22,24)(H2,21,29,30)(H,25,26,27,28) WNEHLMHMEYRECK-UHFFFAOYSA-N 361196 3'-(2-amino-1H- imidazol-4-yl)-N4- (2-aminoethyl)-2- (2H-tetrazol-5-yl)- [1,1'-biphenyl]-3,4- disulfonamide::US10221163, Example 353::US10544130, Example 353 Metallo-beta-lactamase type 2 1.15 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361196 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361196&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269265 386400585 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863403 NCCNS(=O)(=O)c1ccc(-c2cccc(SCC(N)CO)c2)c(-c2nn[nH]n2)c1S(N)(=O)=O 361197 3'-((2-amino-3- hydroxypropyl)thio)- N4-(2-aminoethyl)- 2-(2H-tetrazol-5-yl)- [1,1'-biphenyl]-3,4- disulfonamide::US10221163, Example 354::US10544130, Example 354 Metallo-beta-lactamase type 2 0.453 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361197 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361197&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269266 386400586 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863406 NCCNS(=O)(=O)c1ccc(-c2cccc3ccc(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C18H19N9O4S2/c19-8-9-22-33(30,31)13-6-5-11(12-3-1-2-10-4-7-14(20)23-16(10)12)15(17(13)32(21,28)29)18-24-26-27-25-18/h1-7,22H,8-9,19H2,(H2,20,23)(H2,21,28,29)(H,24,25,26,27) XQMXOQCDPKRVCW-UHFFFAOYSA-N 361198 N1-(2-aminoethyl)- 4-(2-aminoquinolin- 8-yl)-3-(2H-tetrazol- 5-yl)benzene-1,2- disulfonamide::US10221163, Example 355::US10544130, Example 355 Metallo-beta-lactamase type 2 0.200 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361198 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361198&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269267 386400587 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863409 NCCNS(=O)(=O)c1ccc(-c2cccc(SC[C@H](O)CN)c2)c(-c2nn[nH]n2)c1S(N)(=O)=O 361199 (R)-3'-((3-amino-2- hydroxypropyl)thio)- N4-(2-aminoethyl)- 2-(2H-tetrazol-5-yl)- [1,1'-biphenyl]-3,4- disulfonamide::US10221163, Example 356::US10544130, Example 356 Metallo-beta-lactamase type 2 1.41 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361199 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361199&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269268 386400588 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863412 NCCNS(=O)(=O)c1ccc(-c2cccc(SC[C@@H](O)CN)c2)c(-c2nn[nH]n2)c1S(N)(=O)=O 361200 (S)-5'-(3-amino-2- hydroxypropylthio)- N4-(2-aminoethyl)- 2-(2H-tetrazol-5- yl)biphenyl-3,4- disulfonamide::US10221163, Example 357::US10544130, Example 357 Metallo-beta-lactamase type 2 1.21 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361200 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361200&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269269 386400589 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863415 NCCNS(=O)(=O)c1ccc(-c2cccnc2N)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C14H17N9O4S2/c15-5-7-19-29(26,27)10-4-3-8(9-2-1-6-18-13(9)16)11(12(10)28(17,24)25)14-20-22-23-21-14/h1-4,6,19H,5,7,15H2,(H2,16,18)(H2,17,24,25)(H,20,21,22,23) XULNQSBXNLRQGP-UHFFFAOYSA-N 361201 N1-(2-aminoethyl)- 4-(2-aminopyridin- 3-yl)-3-(2H-tetrazol- 5-yl)benzene-1,2- disulfonamide::US10221163, Example 358::US10544130, Example 358 Metallo-beta-lactamase type 2 4.05 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361201 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361201&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269270 386400590 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863418 NCCNS(=O)(=O)c1ccc(-c2cnc3cc[nH]c3c2)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C16H17N9O4S2/c17-4-6-21-31(28,29)13-2-1-10(9-7-12-11(20-8-9)3-5-19-12)14(15(13)30(18,26)27)16-22-24-25-23-16/h1-3,5,7-8,19,21H,4,6,17H2,(H2,18,26,27)(H,22,23,24,25) JTJBIUPVRAYOQB-UHFFFAOYSA-N 361202 N1-(2-aminoethyl)- 4-(1H-pyrrolo[3,2- b]pyridin-6-yl)-3- (2H-tetrazol-5- yl)benzene-1,2- disulfonamide::US10221163, Example 359::US10544130, Example 359 Metallo-beta-lactamase type 2 1.61 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361202 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361202&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269271 386400591 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863421 NCCNS(=O)(=O)c1ccc(-c2cccc3ncccc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C18H18N8O4S2/c19-8-10-22-32(29,30)15-7-6-13(11-3-1-5-14-12(11)4-2-9-21-14)16(17(15)31(20,27)28)18-23-25-26-24-18/h1-7,9,22H,8,10,19H2,(H2,20,27,28)(H,23,24,25,26) WEHSIJUBIMRXIV-UHFFFAOYSA-N 427524 N1-(2-aminoethyl)- 4-(quinolin-5-yl)-3- (2H-tetrazol-5- yl)benzene-1,2- disulfonamide::US10544130, Example 360 Metallo-beta-lactamase type 2 0.381 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=427524 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=427524&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 154732634 434317298 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863424 NCCNS(=O)(=O)c1ccc(-c2cccn3ccnc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C16H17N9O4S2/c17-5-6-20-31(28,29)12-4-3-10(11-2-1-8-25-9-7-19-16(11)25)13(14(12)30(18,26)27)15-21-23-24-22-15/h1-4,7-9,20H,5-6,17H2,(H2,18,26,27)(H,21,22,23,24) ZUMVYUASFRNBGF-UHFFFAOYSA-N 361204 N1-(2-aminoethyl)- 4-(imidazo[1,2- a]pyridin-8-yl)-3- (2H-tetrazol-5- yl)benzene-1,2- disulfonamide::US10221163, Example 361::US10544130, Example 361 Metallo-beta-lactamase type 2 0.147 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361204 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361204&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311756 386400593 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863427 NC[C@H](CO)NS(=O)(=O)c1ccc(-c2ccnc(N)c2)c(-c2nn[nH]n2)c1S(N)(=O)=O 361205 (R)—N1-(1-amino-3-hydroxypropan-2-yl)-4-(2-aminopyridin-4-yl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 362::US10544130, Example 362 Metallo-beta-lactamase type 2 9.51 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361205 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361205&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311172 386400594 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863430 NC[C@H](CO)NS(=O)(=O)c1ccc(-c2cccc3sc(CN)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O 361206 (R)—N1-(1-amino-3-hydroxypropan-2-yl)-4-(2-(aminomethyl)benzo[d]thiazol-4-yl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 363::US10544130, Example 363 Metallo-beta-lactamase type 2 3.67 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361206 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361206&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135310682 386400595 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863433 NC[C@H](CO)NS(=O)(=O)c1ccc(-c2cccc(N)n2)c(-c2nn[nH]n2)c1S(N)(=O)=O 361207 (R)—N1-(1-amino-3-hydroxypropan-2-yl)-4-(6-aminopyridin-2-yl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 364::US10544130, Example 364 Metallo-beta-lactamase type 2 14.6 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361207 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361207&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311380 386400596 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863436 N[C@@H](CO)CNS(=O)(=O)c1ccc(-c2ccc(N)nc2)c(-c2nn[nH]n2)c1S(N)(=O)=O 361208 (R)—N1-(2-amino-3-hydroxypropyl)-4-(6-aminopyridin-3-yl)-3-(2H-tetrazol-5-yl) benzene-1,2-disulfonamide::US10221163, Example 365::US10544130, Example 365 Metallo-beta-lactamase type 2 0.590 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361208 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361208&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124158566 386400597 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863439 Nc1nc2c(cccc2s1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)NC[C@]1(N)CCNC1 361209 (S)-4-(2-aminobenzo[d]thiazol-4-yl)-N1-((3-aminopyrrolidin-3-yl)methyl)-3-(2H-tetrazol-5-yl) benzene-1,2-disulfonamide::US10221163, Example 366::US10544130, Example 366 Metallo-beta-lactamase type 2 0.075 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361209 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361209&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311474 386400598 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863442 Nc1nc2c(cccc2s1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)NC[C@@]1(N)CCNC1 361210 (R)-4-(2-aminobenzo[d]thiazol-4-yl)-N1-((3-aminopyrrolidin-3-yl)methyl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 367::US10544130, Example 367 Metallo-beta-lactamase type 2 0.077 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361210 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361210&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135310718 386400599 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863445 Nc1ccc(cn1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)NC[C@]1(N)CCNC1 361211 (S)-4-(6-aminopyridin-3-yl)-N1-((3-aminopyrrolidin-3-yl)methyl)-3-(2H -tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 368::US10544130, Example 368 Metallo-beta-lactamase type 2 0.304 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361211 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361211&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311698 386400600 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863448 Nc1ccc(cn1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)NC[C@@]1(N)CCNC1 361212 (R)-4-(6-aminopyridin-3-yl)-N1-((3-aminopyrrolidin-3-yl)methyl)-3-(2H -tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 369::US10544130, Example 369 Metallo-beta-lactamase type 2 0.508 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361212 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361212&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135310761 386400601 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862473 Nc1nc2c(cccc2s1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)N1CCC(F)(F)C1 InChI=1S/C18H16F2N8O4S3/c19-18(20)6-7-28(8-18)35(31,32)12-5-4-9(10-2-1-3-11-14(10)23-17(21)33-11)13(15(12)34(22,29)30)16-24-26-27-25-16/h1-5H,6-8H2,(H2,21,23)(H2,22,29,30)(H,24,25,26,27) CJRRJWJKRXTHEF-UHFFFAOYSA-N 360887 3-(2-amino-1,3- benzothiazol-4-yl)-6-[(3,3- difluoropyrrolidin-1- yl)sulfonyl]-2-(1H- tetrazol-5- yl)benzenesulfonamide::US10221163, Example 43::US10544130, Example 43 Metallo-beta-lactamase type 2 1.23 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360887 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360887&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311090 386400280 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862476 Nc1nc2c(cccc2s1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)N1CCS(=O)CC1 InChI=1S/C18H18N8O5S4/c19-18-21-15-11(2-1-3-12(15)32-18)10-4-5-13(35(30,31)26-6-8-33(27)9-7-26)16(34(20,28)29)14(10)17-22-24-25-23-17/h1-5H,6-9H2,(H2,19,21)(H2,20,28,29)(H,22,23,24,25) HMLMVOVUUWOJIT-UHFFFAOYSA-N 360888 3-(2-amino-1,3- benzothiazol-4-yl)-6-[(1- oxidothiomorpholin-4- yl)sulfonyl]-2-(1H- tetrazol-5- yl)benzenesulfonamide::US10221163, Example 44::US10544130, Example 44 Metallo-beta-lactamase type 2 2.22 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360888 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360888&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311642 386400281 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862479 CS(=O)(=O)C1CCN(C1)S(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nnn[nH]2)c1S(N)(=O)=O 360889 3-(2-amino-1,3- benzothiazol-4-yl)-6-{[3- (methylsulfonyl)pyrrolidin- 1-yl]sulfonyl}-2-(1H- tetrazol-5- yl)benzenesulfonamide::US10221163, Example 45::US10544130, Example 45 Metallo-beta-lactamase type 2 1.65 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360889 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360889&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311815 386400282 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862482 Nc1nc2c(cccc2s1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)NCC1(F)CNC1 InChI=1S/C18H18FN9O4S3/c19-18(6-22-7-18)8-23-35(31,32)12-5-4-9(10-2-1-3-11-14(10)24-17(20)33-11)13(15(12)34(21,29)30)16-25-27-28-26-16/h1-5,22-23H,6-8H2,(H2,20,24)(H2,21,29,30)(H,25,26,27,28) FBOXLDIWBOPBGH-UHFFFAOYSA-N 360890 4-(2-amino-1,3- benzothiazol-4-yl)-N1-[(3- fluoroazetidin-3- yl)methyl]-3-(1H-tetrazol- 5-yl)benzene-1,2- disulfonamide::US10221163, Example 46::US10221163, Example 91::US10544130, Example 91 Metallo-beta-lactamase type 2 0.289 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360890 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360890&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311332 386400283 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862485 NCC(F)(F)CNS(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nnn[nH]2)c1S(N)(=O)=O InChI=1S/C17H17F2N9O4S3/c18-17(19,6-20)7-23-35(31,32)11-5-4-8(9-2-1-3-10-13(9)24-16(21)33-10)12(14(11)34(22,29)30)15-25-27-28-26-15/h1-5,23H,6-7,20H2,(H2,21,24)(H2,22,29,30)(H,25,26,27,28) GAFUGIBXFLEVLZ-UHFFFAOYSA-N 360891 4-(2-amino-1,3- benzothiazol-4-yl)-N1-(3- amino-2,2-difluoropropyl)- 3-(1H-tetrazol-5- yl)benzene-1,2- disulfonamide::US10221163, Example 47::US10544130, Example 47 Metallo-beta-lactamase type 2 0.484 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360891 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360891&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311735 386400284 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862488 Nc1nc2c(cccc2s1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)N1CC2(C1)CCNC2 InChI=1S/C20H21N9O4S3/c21-19-24-16-12(2-1-3-13(16)34-19)11-4-5-14(17(35(22,30)31)15(11)18-25-27-28-26-18)36(32,33)29-9-20(10-29)6-7-23-8-20/h1-5,23H,6-10H2,(H2,21,24)(H2,22,30,31)(H,25,26,27,28) MOHHMIRAZDGHTA-UHFFFAOYSA-N 360892 3-(2-amino-1,3- benzothiazol-4-yl)-6-(2,6- diazaspiro[3.4]oct-2- ylsulfonyl)-2-(1H-tetrazol- 5-yl)benzenesulfonamide::US10221163, Example 48::US10544130, Example 48 Metallo-beta-lactamase type 2 0.951 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360892 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360892&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311094 386400285 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862491 NC(CCNS(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nnn[nH]2)c1S(N)(=O)=O)C(F)(F)F 360893 4-(2-amino-1,3- benzothiazol-4-yl)-N1-(3- amino-4,4,4- trifluorobutyl)-3-(1H- tetrazol-5-yl)benzene-1,2- disulfonamide::US10221163, Example 49::US10544130, Example 49 Metallo-beta-lactamase type 2 0.413 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360893 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360893&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135310985 386400286 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862494 Nc1nc2c(cccc2s1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)N[C@H]1CO[C@@H]2[C@H](O)CO[C@@H]12 360894 2-({[4-(2-amino-1,3- benzothiazol-4-yl)-2- sulfamoyl-3-(1H-tetrazol- 5- yl)phenyl]sulfonyl}amino)- 1,4:3,6-dianhydro-2- deoxy-D-allitol::US10221163, Example 50::US10544130, Example 50 Metallo-beta-lactamase type 2 0.263 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360894 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360894&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135312032 386400287 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862497 CC(CN1CCOCC1)NS(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nnn[nH]2)c1S(N)(=O)=O 360895 4-(2-amino-1,3- benzothiazol-4-yl)-N1-(1- methyl-2-morpholin-4- ylethyl)-3-(1H-tetrazol-5- yl)benzene-1,2- disulfonamide::US10221163, Example 51::US10544130, Example 51 Metallo-beta-lactamase type 2 0.393 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360895 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360895&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135310680 386400288 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862500 CN(C)CCCN(C)S(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nnn[nH]2)c1S(N)(=O)=O InChI=1S/C20H25N9O4S3/c1-28(2)10-5-11-29(3)36(32,33)15-9-8-12(13-6-4-7-14-17(13)23-20(21)34-14)16(18(15)35(22,30)31)19-24-26-27-25-19/h4,6-9H,5,10-11H2,1-3H3,(H2,21,23)(H2,22,30,31)(H,24,25,26,27) AHMBFQAMCZCYCG-UHFFFAOYSA-N 360896 4-(2-amino-1,3- benzothiazol-4-yl)-N1-[3- (dimethylamino)propyl]- N~1~-methyl-3-(1H- tetrazol-5-yl)benzene-1,2- disulfonamide::US10221163, Example 52::US10544130, Example 52 Metallo-beta-lactamase type 2 5.94 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360896 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360896&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311218 386400289 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862503 CN1CCC(C1)NS(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nnn[nH]2)c1S(N)(=O)=O 360897 4-(2-amino-1,3- benzothiazol-4-yl)-N1-(1- methylpyrrolidin-3-yl)-3- (1H-tetrazol-5-yl)benzene- 1,2-disulfonamide::US10221163, Example 53::US10544130, Example 53 Metallo-beta-lactamase type 2 0.298 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360897 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360897&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135310925 386400290 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862506 CN(C1CCN(C)C1)S(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nnn[nH]2)c1S(N)(=O)=O 360898 4-(2-amino-1,3- benzothiazol-4-yl)-N1- methyl-N1-(1- methylpyrrolidin-3-yl)-3- (1H-tetrazol-5-yl)benzene- 1,2-disulfonamide::US10221163, Example 54::US10544130, Example 54 Metallo-beta-lactamase type 2 1.93 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360898 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360898&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311010 386400291 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862509 Nc1nc2c(cccc2s1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)N1CCC(N)(CO)C1 360899 3-(2-amino-1,3- benzothiazol-4-yl)-6-{[3- amino-3- (hydroxymethyl)pyrrolidin- 1-yl]sulfonyl}-2-(1H- tetrazol-5- yl)benzenesulfonamide::US10221163, Example 55::US10544130, Example 55 Metallo-beta-lactamase type 2 0.860 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360899 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360899&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135312002 386400292 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862512 CCC1(CCNC1)NS(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nnn[nH]2)c1S(N)(=O)=O 360900 4-(2-amino-1,3- benzothiazol-4-yl)-N1-(3- ethylpyrrolidin-3-yl)-3- (1H-tetrazol-5-yl)benzene- 1,2-disulfonamide::US10221163, Example 56::US10544130, Example 56 Metallo-beta-lactamase type 2 0.342 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360900 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360900&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311472 386400293 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862515 CC1(CCCNC1)NS(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nnn[nH]2)c1S(N)(=O)=O 360901 4-(2-amino-1,3- benzothiazol-4-yl)-N1-(3- methylpiperidin-3-yl)-3- (1H-tetrazol-5-yl)benzene- 1,2-disulfonamide::US10221163, Example 57::US10544130, Example 57 Metallo-beta-lactamase type 2 0.554 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360901 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360901&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311340 386400294 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862518 Nc1nc2c(cccc2s1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)N[C@@H]1CNC[C@@H]1F 360902 4-(2-amino-1,3- benzothiazol-4-yl)-N1- [(3R,4S)-4- fluoropyrrolidin-3-yl]-3- (1H-tetrazol-5-yl)benzene- 1,2-disulfonamide::US10221163, Example 58::US10544130, Example 58 Metallo-beta-lactamase type 2 0.759 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360902 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360902&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311849 386400295 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862521 Nc1nc2c(cccc2s1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)N[C@H]1CNC[C@@H]1F 360903 4-(2-amino-1,3- benzothiazol-4-yl)-N1- [(3S,4S)-4- fluoropyrrolidin-3-yl]-3- (1H-tetrazol-5-yl)benzene- 1,2-disulfonamide::US10221163, Example 59::US10544130, Example 59 Metallo-beta-lactamase type 2 0.558 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360903 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360903&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135310691 386400296 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862524 Nc1nc2c(cccc2s1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)N[C@H]1CCNC1 360904 4-(2-amino-1,3- benzothiazol-4-yl)-N1- [(3S)-pyrrolidin-3-yl]-3- (1H-tetrazol-5-yl)benzene- 1,2-disulfonamide::US10221163, Example 60::US10544130, Example 60 Metallo-beta-lactamase type 2 0.679 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360904 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360904&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311395 386400297 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862527 N[C@H]1CCN(C1)S(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nnn[nH]2)c1S(N)(=O)=O 360905 3-(2-amino-1,3- benzothiazol-4-yl)-6- {[(3S)-3-aminopyrrolidin- 1-yl]sulfonyl}-2-(1H- tetrazol-5- yl)benzenesulfonamide::US10221163, Example 61::US10544130, Example 61 Metallo-beta-lactamase type 2 1.47 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360905 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360905&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311513 386400298 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862530 N[C@@H]1CCN(C1)S(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nnn[nH]2)c1S(N)(=O)=O 360906 3-(2-amino-1,3- benzothiazol-4-yl)-6- {[(3R)-3-aminopyrrolidin- 1-yl]sulfonyl}-2-(1H- tetrazol-5- yl)benzenesulfonamide::US10221163, Example 62::US10544130, Example 62 Metallo-beta-lactamase type 2 1.28 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360906 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360906&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311128 386400299 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862533 Nc1nc2c(cccc2s1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)N[C@@H]1CCNC1 360907 4-(2-amino-1,3- benzothiazol-4-yl)-N1- [(3R)-pyrrolidin-3-yl]-3- (1H-tetrazol-5-yl)benzene- 1,2-disulfonamide::US10221163, Example 63::US10544130, Example 63 Metallo-beta-lactamase type 2 0.307 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360907 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360907&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135310825 386400300 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863451 NC[C@H](N)CNS(=O)(=O)c1ccc(-c2cccc3[nH]c(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C17H19N11O4S2/c18-6-8(19)7-22-34(31,32)12-5-4-9(10-2-1-3-11-14(10)24-17(20)23-11)13(15(12)33(21,29)30)16-25-27-28-26-16/h1-5,8,22H,6-7,18-19H2,(H2,20,23)(H2,21,29,30)/b10-9+/t8-/m0/s1 AFCPLFGHFODPGV-VPOJCXOPSA-N 361213 (S)-4-(2-amino-1H-benzo[d]imidazol-4-yl)-N1-(2,3-di aminopropyl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 370::US10544130, Example 370 Metallo-beta-lactamase type 2 0.663 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361213 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361213&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135310989 386400602 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863454 NC[C@H](N)CNS(=O)(=O)c1ccc(-c2cccc3ccc(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O 361214 (S)-4-(2-aminoquinolin-8-yl)-N1-(2,3-diaminopropyl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 371::US10544130, Example 371 Metallo-beta-lactamase type 2 0.289 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361214 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361214&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124158515 386400603 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863457 NC[C@H](N)CNS(=O)(=O)c1ccc(-c2cnc(N)s2)c(-c2nn[nH]n2)c1S(N)(=O)=O 361215 (S)-4-(2-aminothiazol-5- yl)-N1-(2,3- diaminopropyl)-3-(2H- tetrazol-5-yl)benzene-1,2- disulfonamide::US10221163, Example 372::US10544130, Example 372 Metallo-beta-lactamase type 2 1.27 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361215 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361215&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311600 386400604 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863460 NC[C@H](N)CNS(=O)(=O)c1ccc(-c2cnc3cc[nH]c3c2)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C17H18N10O4S2/c18-6-10(19)8-23-33(30,31)14-2-1-11(9-5-13-12(22-7-9)3-4-21-13)15(16(14)32(20,28)29)17-24-26-27-25-17/h1-5,7,10,23H,6,8,18-19H2,(H2,20,28,29)/b11-9-/t10-/m0/s1 CXRCAVIUGHWDFE-RGAIUGGKSA-N 361216 (S)-N1-(2,3- diaminopropyl)-4-(1H- pyrrolo[3,2-b]pyridin-6-yl)- 3-(2H-tetrazol-5- yl)benzene-1,2- disulfonamide::US10221163, Example 373::US10544130, Example 373 Metallo-beta-lactamase type 2 0.495 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361216 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361216&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269273 386400605 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863463 NC[C@H](N)CNS(=O)(=O)c1ccc(-c2cccn3ccnc23)c(-c2nn[nH]n2)c1S(N)(=O)=O 361217 (S)-N1-(2,3- diaminopropyl)-4- (imidazo[1,2-a]pyridin-8- yl)-3-(2H-tetrazol-5- yl)benzene-1,2- disulfonamide::US10221163, Example 374::US10544130, Example 374 Metallo-beta-lactamase type 2 0.278 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361217 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361217&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135310685 386400606 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863466 NC[C@@H](N)CNS(=O)(=O)c1ccc(-c2cccc3[nH]c(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C17H19N11O4S2/c18-6-8(19)7-22-34(31,32)12-5-4-9(10-2-1-3-11-14(10)24-17(20)23-11)13(15(12)33(21,29)30)16-25-27-28-26-16/h1-5,8,22H,6-7,18-19H2,(H2,20,23)(H2,21,29,30)/b10-9+/t8-/m1/s1 AFCPLFGHFODPGV-KGSKPCQNSA-N 361218 (R)-4-(2-amino-1H-benzo[d]imidazol-4-yl)-N1-(2,3-diaminopropyl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 375::US10544130, Example 375 Metallo-beta-lactamase type 2 0.600 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361218 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361218&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311053 386400607 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863469 NC[C@@H](N)CNS(=O)(=O)c1ccc(-c2cccc3ccc(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O 361219 (R)-4-(2-aminoquinolin- 8-yl)-N1-(2,3- diaminopropyl)-3-(2H- tetrazol-5-yl)benzene- 1,2-disulfonamide::US10221163, Example 376::US10544130, Example 376 Metallo-beta-lactamase type 2 0.273 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361219 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361219&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269274 386400608 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863472 NC[C@@H](N)CNS(=O)(=O)c1ccc(-c2cnc(N)s2)c(-c2nn[nH]n2)c1S(N)(=O)=O 361220 (R)-4-(2-aminothiazol-5- yl)-N1-(2,3- diaminopropyl)-3-(2H- tetrazol-5-yl)benzene- 1,2-disulfonamide::US10221163, Example 377::US10544130, Example 377 Metallo-beta-lactamase type 2 1.18 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361220 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361220&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311851 386400609 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863475 NC[C@@H](N)CNS(=O)(=O)c1ccc(-c2cnc3cc[nH]c3c2)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C17H18N10O4S2/c18-6-10(19)8-23-33(30,31)14-2-1-11(9-5-13-12(22-7-9)3-4-21-13)15(16(14)32(20,28)29)17-24-26-27-25-17/h1-5,7,10,23H,6,8,18-19H2,(H2,20,28,29)/b11-9-/t10-/m1/s1 CXRCAVIUGHWDFE-QLWWJYNRSA-N 361221 (R)-N1-(2,3- diaminopropyl)-4-(1H- pyrrolo[3,2-b]pyridin-6- yl)-3-(2H-tetrazol- 5-yl)benzene-1,2- disulfonamide::US10221163, Example 378::US10544130, Example 378 Metallo-beta-lactamase type 2 0.354 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361221 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361221&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269275 386400610 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863478 NC[C@@H](CO)NS(=O)(=O)c1ccc(-c2cccc3[nH]c(CN)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C18H20N10O5S2/c19-6-9(8-29)26-35(32,33)13-5-4-10(11-2-1-3-12-16(11)23-14(7-20)22-12)15(17(13)34(21,30)31)18-24-27-28-25-18/h1-5,9,26,29H,6-8,19-20H2,(H2,21,30,31)/b11-10+/t9-/m0/s1 WYNKHXHXYYJZQW-YHTNPHCKSA-N 361222 (S)—N1-(1-amino-3-hydroxypropan-2-yl)-4-(2-(aminomethyl)-1H-benzo[d]imidazol-4-yl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 379::US10544130, Example 379 Metallo-beta-lactamase type 2 0.626 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361222 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361222&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311289 386400611 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863481 NC[C@@H](CO)NS(=O)(=O)c1ccc(-c2ccnc(N)c2)c(-c2nn[nH]n2)c1S(N)(=O)=O 361223 (S)—N1-(1-amino-3-hydroxypropan-2-yl)-4-(2-aminopyridin-4-yl)-3-(2H -tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 380::US10544130, Example 380 Metallo-beta-lactamase type 2 0.544 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361223 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361223&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135310773 386400612 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863484 NC[C@@H](CO)NS(=O)(=O)c1ccc(-c2cccc3sc(CN)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O 361224 (S)—N1-(1-amino-3-hydroxypropan-2-yl)-4-(2-(aminomethyl)benzo[d]thiazol-4-yl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 381::US10544130, Example 381 Metallo-beta-lactamase type 2 0.241 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361224 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361224&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311161 386400613 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863487 NC[C@@H](CO)NS(=O)(=O)c1ccc(-c2cccc(N)n2)c(-c2nn[nH]n2)c1S(N)(=O)=O 361225 (S)—N1-(1-amino-3-hydroxypropan-2-yl)-4-(6-aminopyridin-2-yl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 382::US10544130, Example 382 Metallo-beta-lactamase type 2 0.651 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361225 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361225&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135310831 386400614 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863490 C[C@H](CN)NS(=O)(=O)c1ccc(-c2cccc3[nH]c(CN)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C18H20N10O4S2/c1-9(7-19)26-34(31,32)13-6-5-10(11-3-2-4-12-16(11)23-14(8-20)22-12)15(17(13)33(21,29)30)18-24-27-28-25-18/h2-6,9,26H,7-8,19-20H2,1H3,(H2,21,29,30)/b11-10+/t9-/m1/s1 WDZGUMLHLJCPQL-HNLKAFMCSA-N 361226 (R)-4-(2-(aminomethyl)-1H-benzo[d]imidazol-4-yl)-N1-(1-aminopropan-2-yl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 383::US10544130, Example 383 Metallo-beta-lactamase type 2 0.536 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361226 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361226&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311365 386400615 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863493 C[C@H](CN)NS(=O)(=O)c1ccc(-c2cccn3ccnc23)c(-c2nn[nH]n2)c1S(N)(=O)=O 361227 (R)—N1-(1-aminopropan-2-yl)-4-(imidazo[1,2-a]pyridin-8-yl)-3-(2H -tetrazol-5-yl) benzene-1,2-disulfonamide::US10221163, Example 384::US10544130, Example 384 Metallo-beta-lactamase type 2 0.054 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361227 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361227&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124158552 386400616 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863496 NCC(CN)NS(=O)(=O)c1ccc(-c2cccc3[nH]c(CN)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C18H23N11O4S2/c19-6-9(7-20)27-35(32,33)13-5-4-10(11-2-1-3-12-16(11)24-14(8-21)23-12)15(17(13)34(22,30)31)18-25-28-29-26-18/h1-5,9,27H,6-8,19-21H2,(H,23,24)(H2,22,30,31)(H,25,26,28,29) BFDZAXLYGMAZBQ-UHFFFAOYSA-N 361228 4-(2-(Aminomethyl)-1H-benzo[d]imidazol-4-yl)-N1-(1,3-diaminopropan-2-yl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 385::US10544130, Example 385 Metallo-beta-lactamase type 2 0.782 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361228 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361228&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311729 386400617 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863499 NCC(CN)NS(=O)(=O)c1ccc(-c2cccn3ccnc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C17H20N10O4S2/c18-8-10(9-19)24-33(30,31)13-4-3-11(12-2-1-6-27-7-5-21-17(12)27)14(15(13)32(20,28)29)16-22-25-26-23-16/h1-7,10,24H,8-9,18-19H2,(H2,20,28,29)(H,22,23,25,26) KCQQRBQSGGONSX-UHFFFAOYSA-N 361229 N1-(1,3-diaminopropan-2-yl)-4-(imidazo[1,2-c]pyridin-8-yl)-3-(2H-tetrazol-5-yl) benzene-1,2-disulfonamide::US10221163, Example 386::US10544130, Example 386 Metallo-beta-lactamase type 2 0.141 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361229 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361229&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 137537738 386400618 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863502 Nc1nc2c(cccc2s1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)NCC1(O)CNC1 InChI=1S/C18H19N9O5S3/c19-17-23-14-10(2-1-3-11(14)33-17)9-4-5-12(35(31,32)22-8-18(28)6-21-7-18)15(34(20,29)30)13(9)16-24-26-27-25-16/h1-5,21-22,28H,6-8H2,(H2,19,23)(H2,20,29,30)(H,24,25,26,27) PRVKGOPWBRUUTC-UHFFFAOYSA-N 427551 4-(2-amino-1,3- benzothiazol-4-yl)- N1-[(3- hydroxyazetidin-3- yl)methyl]-3-(2H- tetrazol-5- yl)benzene-1,2- disulfonamide::US10544130, Example 387 Metallo-beta-lactamase type 2 0.244 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=427551 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=427551&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 154732661 434317325 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863505 N[C@@H]1C[C@H]1NS(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O 427552 4-(2-amino-1,3- benzothiazol-4-yl)- N1-[(1R,2R)-2- aminocyclopropyl]-3- (2H-tetrazol-5- yl)benzene-1,2- disulfonamide::US10544130, Example 388 Metallo-beta-lactamase type 2 0.324 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=427552 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=427552&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 154732662 434317326 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863508 C[C@@H](CN)NS(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O 427553 4-(2-amino-1,3- benzothiazol-4-yl)- N1-[(1S)-2-amino-1- methylethyl]-3-(2H- tetrazol-S- yl)benzene-1,2- disulfonamide::US10544130, Example 389 Metallo-beta-lactamase type 2 1.81 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=427553 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=427553&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 154732663 434317327 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863511 C[C@@H](N)CNS(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O 427554 4-(2-amino-1,3- benzothiazol-4-yl)- N1-[(2R)-2- aminopropyl]-3-(2H- tetrazol-5- yl)benzene-1,2- disulfonamide::US10544130, Example 390 Metallo-beta-lactamase type 2 0.341 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=427554 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=427554&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 154732664 434317328 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862536 CN(C1CCCNC1)S(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nnn[nH]2)c1S(N)(=O)=O 360908 4-(2-amino-1,3- benzothiazol-4-yl)-N1- methyl-N1-piperidin-3-yl- 3-(1H-tetrazol-5- yl)benzene-1,2- disulfonamide::US10221163, Example 64::US10544130, Example 64 Metallo-beta-lactamase type 2 2.16 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360908 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360908&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311052 386400301 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862539 CN([C@H]1CCNC1)S(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nnn[nH]2)c1S(N)(=O)=O 360909 4-(2-amino-1,3- benzothiazol-4-yl)-N1- methyl-N1-[(3S)- pyrrolidin-3-yl]-3-(1H- tetrazol-5-yl)benzene-1,2- disulfonamide::US10221163, Example 65::US10544130, Example 65 Metallo-beta-lactamase type 2 0.703 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360909 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360909&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311008 386400302 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862542 N[C@H]1CCCN(C1)S(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nnn[nH]2)c1S(N)(=O)=O 360910 3-(2-amino-1,3- benzothiazol-4-yl)-6- {[(3S)-3-aminopiperidin-1- yl]sulfonyl}-2-(1H- tetrazol-5- yl)benzenesulfonamide::US10221163, Example 66::US10544130, Example 66 Metallo-beta-lactamase type 2 2.26 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360910 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360910&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311948 386400303 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862545 Nc1nc2c(cccc2s1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)N[C@H]1CCCNC1 360911 4-(2-amino-1,3- benzothiazol-4-yl)-N1- [(3S)-piperidin-3-yl]-3- (1H-tetrazol-5-yl)benzene- 1,2-disulfonamide::US10221163, Example 67::US10544130, Example 67 Metallo-beta-lactamase type 2 0.488 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360911 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360911&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311974 386400304 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862548 COc1ccc(CN(Cc2ccc(OC)cc2)S(=O)(=O)c2c(ccc(I)c2-c2nnn(Cc3ccc(OC)cc3)n2)S(=O)(=O)N[C@@H]2CCN(C2)C(=O)OC(C)(C)C)cc1 InChI=1S/C40H46IN7O9S2/c1-40(2,3)57-39(49)46-22-21-30(26-46)44-58(50,51)35-20-19-34(41)36(38-42-45-48(43-38)25-29-11-17-33(56-6)18-12-29)37(35)59(52,53)47(23-27-7-13-31(54-4)14-8-27)24-28-9-15-32(55-5)16-10-28/h7-20,30,44H,21-26H2,1-6H3/t30-/m1/s1 URIMKCJWSVIKRZ-SSEXGKCCSA-N 360912 (R)-tert-butyl 3-(2-(N,N-bis(4- methoxybenzyl)sulfamoyl)-4- iodo-3-(2-(4-methoxybenzyl)- 2H-tetrazol-5- yl)phenylsulfonamido)pyrrolidine- 1-carboxylate::US10221163, Example 68::US10544130, Example 72 Metallo-beta-lactamase type 2 1.97 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360912 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360912&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124158354 386400305 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862551 Nc1nc2c(cccc2s1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)N[C@@H]1CCCNC1 360913 4-(2-amino-1,3- benzothiazol-4-yl)-N1- [(3R)-piperidin-3-yl]-3- (1H-tetrazol-5-yl)benzene- 1,2-disulfonamide::US10221163, Example 69::US10544130, Example 69 Metallo-beta-lactamase type 2 0.184 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360913 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360913&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135310890 386400306 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862554 NC[C@@H]1CCN(C1)S(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nnn[nH]2)c1S(N)(=O)=O 360914 3-(2-amino-1,3- benzothiazol-4-yl)-6- {[(3S)-3- (aminomethyl)pyrrolidin- 1-yl]sulfonyl}-2-(1H- tetrazol-5- yl)benzenesulfonamide::US10221163, Example 70::US10221163, Example 94::US10544130, Example 94 Metallo-beta-lactamase type 2 2.31 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360914 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360914&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311199 386400307 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862557 N[C@H]1C[C@@H](C1)NS(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nnn[nH]2)c1S(N)(=O)=O 360915 4-(2-amino-1,3- benzothiazol-4-yl)-N1- (trans-3-aminocyclobutyl)- 3-(1H-tetrazol-5- yl)benzene-1,2- disulfonamide::US10221163, Example 71::US10544130, Example 98 Metallo-beta-lactamase type 2 0.355 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360915 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360915&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311334 386400308 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862560 COc1ccc(CN(Cc2ccc(OC)cc2)S(=O)(=O)c2c(ccc(I)c2-c2nnn(Cc3ccc(OC)cc3)n2)S(=O)(=O)N[C@@H]2CCN(C2)C(=O)OC(C)(C)C)cc1 InChI=1S/C40H46IN7O9S2/c1-40(2,3)57-39(49)46-22-21-30(26-46)44-58(50,51)35-20-19-34(41)36(38-42-45-48(43-38)25-29-11-17-33(56-6)18-12-29)37(35)59(52,53)47(23-27-7-13-31(54-4)14-8-27)24-28-9-15-32(55-5)16-10-28/h7-20,30,44H,21-26H2,1-6H3/t30-/m1/s1 URIMKCJWSVIKRZ-SSEXGKCCSA-N 360912 (R)-tert-butyl 3-(2-(N,N-bis(4- methoxybenzyl)sulfamoyl)-4- iodo-3-(2-(4-methoxybenzyl)- 2H-tetrazol-5- yl)phenylsulfonamido)pyrrolidine- 1-carboxylate::US10221163, Example 68::US10544130, Example 72 Metallo-beta-lactamase type 2 0.270 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360912 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360912&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124158354 386400305 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862563 COc1ccc(CN(Cc2ccc(OC)cc2)S(=O)(=O)c2c(ccc(I)c2-c2nnn(Cc3ccc(OC)cc3)n2)S(=O)(=O)NC[C@@H](CO)NC(=O)OC(C)(C)C)cc1 InChI=1S/C39H46IN7O10S2/c1-39(2,3)57-38(49)42-29(25-48)21-41-58(50,51)34-20-19-33(40)35(37-43-45-47(44-37)24-28-11-17-32(56-6)18-12-28)36(34)59(52,53)46(22-26-7-13-30(54-4)14-8-26)23-27-9-15-31(55-5)16-10-27/h7-20,29,41,48H,21-25H2,1-6H3,(H,42,49)/t29-/m0/s1 RZOMAMNKJPYXFW-LJAQVGFWSA-N 360917 (S)-tert-butyl (1-(2-(N,N-bis(4- methoxybenzyl)sulfamoyl)-4- iodo-3-(2-(4-methoxybenzyl)- 2H-tetrazol-5- yl)phenylsulfonamido)-3- hydroxypropan-2-yl)carbamate::US10221163, Example 73::US10544130, Example 73 Metallo-beta-lactamase type 2 0.160 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360917 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360917&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269190 386400310 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862566 COc1ccc(CN(Cc2ccc(OC)cc2)S(=O)(=O)c2c(ccc(I)c2-c2nnn(Cc3ccc(OC)cc3)n2)S(=O)(=O)NC[C@H](O)CNC(=O)OC(C)(C)C)cc1 InChI=1S/C39H46IN7O10S2/c1-39(2,3)57-38(49)41-21-29(48)22-42-58(50,51)34-20-19-33(40)35(37-43-45-47(44-37)25-28-11-17-32(56-6)18-12-28)36(34)59(52,53)46(23-26-7-13-30(54-4)14-8-26)24-27-9-15-31(55-5)16-10-27/h7-20,29,42,48H,21-25H2,1-6H3,(H,41,49)/t29-/m1/s1 SYSQZTFYEUUIMG-GDLZYMKVSA-N 360918 (R)-tert-butyl (3-(2-(N,N-bis(4- methoxybenzyl)sulfamoyl)-4- iodo-3-(2-(4-methoxybenzyl)- 2H-tetrazol-5- yl)phenylsulfonamido)-2- hydroxypropyl)carbamate::US10221163, Example 74::US10544130, Example 74 Metallo-beta-lactamase type 2 0.840 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360918 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360918&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269191 386400311 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862569 COc1ccc(CN(Cc2ccc(OC)cc2)S(=O)(=O)c2c(ccc(I)c2-c2nnn(Cc3ccc(OC)cc3)n2)S(=O)(=O)NC[C@@H](O)CNC(=O)OC(C)(C)C)cc1 InChI=1S/C39H46IN7O10S2/c1-39(2,3)57-38(49)41-21-29(48)22-42-58(50,51)34-20-19-33(40)35(37-43-45-47(44-37)25-28-11-17-32(56-6)18-12-28)36(34)59(52,53)46(23-26-7-13-30(54-4)14-8-26)24-27-9-15-31(55-5)16-10-27/h7-20,29,42,48H,21-25H2,1-6H3,(H,41,49)/t29-/m0/s1 SYSQZTFYEUUIMG-LJAQVGFWSA-N 360919 (S)-tert-butyl (3-(2-(N,N-bis(4- methoxybenzyl)sulfamoyl)-4- iodo-3-(2-(4-methoxybenzyl)- 2H-tetrazol-5- yl)phenylsulfonamido)-2- hydroxypropyl)carbamate::US10221163, Example 75::US10544130, Example 75 Metallo-beta-lactamase type 2 0.158 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360919 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360919&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269192 386400312 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862572 COc1ccc(CN(Cc2ccc(OC)cc2)S(=O)(=O)c2c(ccc(I)c2-c2nnn(Cc3ccc(OC)cc3)n2)S(=O)(=O)NC[C@@H]2CN(CCN2C(=O)OC(C)(C)C)C(=O)OC(C)(C)C)cc1 InChI=1S/C46H57IN8O11S2/c1-45(2,3)65-43(56)52-24-25-54(44(57)66-46(4,5)6)34(30-52)26-48-67(58,59)39-23-22-38(47)40(42-49-51-55(50-42)29-33-14-20-37(64-9)21-15-33)41(39)68(60,61)53(27-31-10-16-35(62-7)17-11-31)28-32-12-18-36(63-8)19-13-32/h10-23,34,48H,24-30H2,1-9H3/t34-/m1/s1 CQVYWECRQQVMBR-UUWRZZSWSA-N 360920 (S)-di-tert-butyl 2-((2-(N,N-bis(4- methoxybenzyl)sulfamoyl)-4- iodo-3-(2-(4-methoxybenzyl)- 2H-tetrazol-5- yl)phenylsulfonamido)methyl) piperazine-1,4-dicarboxylate::US10221163, Example 76::US10544130, Example 76 Metallo-beta-lactamase type 2 0.195 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360920 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360920&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135310667 386400313 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862575 COc1ccc(CN(Cc2ccc(OC)cc2)S(=O)(=O)c2c(ccc(I)c2-c2nnn(Cc3ccc(OC)cc3)n2)S(=O)(=O)NC[C@H]2CN(CCN2C(=O)OC(C)(C)C)C(=O)OC(C)(C)C)cc1 InChI=1S/C46H57IN8O11S2/c1-45(2,3)65-43(56)52-24-25-54(44(57)66-46(4,5)6)34(30-52)26-48-67(58,59)39-23-22-38(47)40(42-49-51-55(50-42)29-33-14-20-37(64-9)21-15-33)41(39)68(60,61)53(27-31-10-16-35(62-7)17-11-31)28-32-12-18-36(63-8)19-13-32/h10-23,34,48H,24-30H2,1-9H3/t34-/m0/s1 CQVYWECRQQVMBR-UMSFTDKQSA-N 360921 (R)-di-tert-butyl 2-((2-(N,N- bis(4-methoxybenzyl)sulfamoyl)- 4-iodo-3-(2-(4-methoxybenzyl)- 2H-tetrazol-5- yl)phenylsulfonamido)methyl) piperazine-1,4-dicarboxylate::US10221163, Example 77::US10544130, Example 77 Metallo-beta-lactamase type 2 0.166 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360921 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360921&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124158315 386400314 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862578 COc1ccc(CN(Cc2ccc(OC)cc2)S(=O)(=O)c2c(ccc(I)c2-c2nnn(Cc3ccc(OC)cc3)n2)S(=O)(=O)NC[C@H](CNC(=O)OCc2ccccc2)NC(=O)OC(C)(C)C)cc1 InChI=1S/C47H53IN8O11S2/c1-47(2,3)67-46(58)51-36(26-49-45(57)66-31-35-10-8-7-9-11-35)27-50-68(59,60)41-25-24-40(48)42(44-52-54-56(53-44)30-34-16-22-39(65-6)23-17-34)43(41)69(61,62)55(28-32-12-18-37(63-4)19-13-32)29-33-14-20-38(64-5)21-15-33/h7-25,36,50H,26-31H2,1-6H3,(H,49,57)(H,51,58)/t36-/m0/s1 SZMQVONRDOVLLM-BHVANESWSA-N 360922 (S)-benzyl tert-butyl (3-(2-(N,N- bis(4-methoxybenzyl)sulfamoyl)- 4-iodo-3-(2-(4-methoxybenzyl)- 2H-tetrazol-5- yl)phenylsulfonamido)propane- 1,2-diyl)dicarbamate::US10221163, Example 78::US10544130, Example 78 Metallo-beta-lactamase type 2 0.234 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360922 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360922&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269193 386400315 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862581 COc1ccc(CN(Cc2ccc(OC)cc2)S(=O)(=O)c2c(ccc(I)c2-c2nnn(Cc3ccc(OC)cc3)n2)S(=O)(=O)N[C@@H](CO)CNC(=O)OC(C)(C)C)cc1 InChI=1S/C39H46IN7O10S2/c1-39(2,3)57-38(49)41-21-29(25-48)44-58(50,51)34-20-19-33(40)35(37-42-45-47(43-37)24-28-11-17-32(56-6)18-12-28)36(34)59(52,53)46(22-26-7-13-30(54-4)14-8-26)23-27-9-15-31(55-5)16-10-27/h7-20,29,44,48H,21-25H2,1-6H3,(H,41,49)/t29-/m1/s1 PKIKBIFPRCUBFS-GDLZYMKVSA-N 360923 (R)-tert-butyl (2-(2-(N,N-bis(4- methoxybenzyl)sulfamoyl)-4- iodo-3-(2-(4-methoxybenzyl)- 2H-tetrazol-5- yl)phenylsulfonamido)-3- hydroxypropyl)carbamate::US10221163, Example 79::US10544130, Example 79 Metallo-beta-lactamase type 2 0.283 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360923 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360923&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269194 386400316 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862584 COc1ccc(CN(Cc2ccc(OC)cc2)S(=O)(=O)c2c(ccc(I)c2-c2nnn(Cc3ccc(OC)cc3)n2)S(=O)(=O)NC[C@H](CO)NC(=O)OCc2ccccc2)cc1 InChI=1S/C42H44IN7O10S2/c1-57-34-15-9-29(10-16-34)24-49(25-30-11-17-35(58-2)18-12-30)62(55,56)40-38(61(53,54)44-23-33(27-51)45-42(52)60-28-32-7-5-4-6-8-32)22-21-37(43)39(40)41-46-48-50(47-41)26-31-13-19-36(59-3)20-14-31/h4-22,33,44,51H,23-28H2,1-3H3,(H,45,52)/t33-/m1/s1 XGFAJSGBLMHBHK-MGBGTMOVSA-N 360924 (R)-benzyl (1-(2-(N,N-bis(4- methoxybenzyl)sulfamoyl)-4- iodo-3-(2-(4-methoxybenzyl)- 2H-tetrazol-5- yl)phenylsulfonamido)-3- hydroxypropan-2-yl)carbamate::US10221163, Example 80::US10544130, Example 80 Metallo-beta-lactamase type 2 0.336 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360924 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360924&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269195 386400317 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862587 COc1ccc(CN(Cc2ccc(OC)cc2)S(=O)(=O)c2c(ccc(I)c2-c2nnn(Cc3ccc(OC)cc3)n2)S(=O)(=O)NC[C@@H](CNC(=O)OC(C)(C)C)NC(=O)OC(C)(C)C)cc1 InChI=1S/C44H55IN8O11S2/c1-43(2,3)63-41(54)46-24-32(48-42(55)64-44(4,5)6)25-47-65(56,57)37-23-22-36(45)38(40-49-51-53(50-40)28-31-14-20-35(62-9)21-15-31)39(37)66(58,59)52(26-29-10-16-33(60-7)17-11-29)27-30-12-18-34(61-8)19-13-30/h10-23,32,47H,24-28H2,1-9H3,(H,46,54)(H,48,55)/t32-/m1/s1 MPKFPGZSQMILTQ-JGCGQSQUSA-N 360925 (R)-di-tert-butyl (3-(2-(N,N- bis(4-methoxybenzyl)sulfamoyl)- 4-iodo-3-(2-(4-methoxybenzyl)- 2H-tetrazol-5- yl)phenylsulfonamido)propane- 1,2-diyl)dicarbamate::US10221163, Example 81::US10544130, Example 81 Metallo-beta-lactamase type 2 0.191 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360925 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360925&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269196 386400318 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862590 COc1ccc(CN(Cc2ccc(OC)cc2)S(=O)(=O)c2c(ccc(I)c2-c2nnn(Cc3ccc(OC)cc3)n2)S(=O)(=O)N[C@H]2CN(C[C@@H]2NC(=O)OC(C)(C)C)C(=O)OC(C)(C)C)cc1 InChI=1S/C45H55IN8O11S2/c1-44(2,3)64-42(55)47-36-27-52(43(56)65-45(4,5)6)28-37(36)50-66(57,58)38-23-22-35(46)39(41-48-51-54(49-41)26-31-14-20-34(63-9)21-15-31)40(38)67(59,60)53(24-29-10-16-32(61-7)17-11-29)25-30-12-18-33(62-8)19-13-30/h10-23,36-37,50H,24-28H2,1-9H3,(H,47,55)/t36-,37-/m0/s1 IAQXVQLDCFUFMS-BCRBLDSWSA-N 427137 (3R,4S)-tert-butyl 3-(2-(N,N- bis(4-methoxybenzyl)sulfamoyl)- 4-iodo-3-(2-(4-methoxybenzyl)- 2H-tetrazol-5- yl)phenylsulfonamido)-4-((tert- butoxycarbonyl)amino) pyrrolidine-1-carboxylate::US10544130, Example 82 Metallo-beta-lactamase type 2 0.206 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=427137 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=427137&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311205 434321451 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862593 COc1ccc(CN(Cc2ccc(OC)cc2)S(=C)(=C)c2c(ccc(I)c2-c2nnn(Cc3ccc(OC)cc3)n2)S(=O)(=O)N[C@H](CO)CNC(=O)OCc2ccccc2)cc1 InChI=1S/C44H48IN7O8S2/c1-57-36-17-11-31(12-18-36)26-51(27-32-13-19-37(58-2)20-14-32)61(4,5)42-40(62(55,56)49-35(29-53)25-46-44(54)60-30-34-9-7-6-8-10-34)24-23-39(45)41(42)43-47-50-52(48-43)28-33-15-21-38(59-3)22-16-33/h6-24,35,49,53H,4-5,25-30H2,1-3H3,(H,46,54)/t35-/m0/s1 BUZYZJLNJPXQJM-DHUJRADRSA-N 427138 (S)-benzyl (2-(2-(N,N-bis(4- methoxybenzyl)sulfamoyl)-4- iodo-3-(2-(4-methoxybenzyl)- 2H-tetrazol-5- yl)phenylsulfonamido)-3- hydroxypropyl)carbamate::US10544130, Example 83 Metallo-beta-lactamase type 2 0.261 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=427138 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=427138&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 154732990 434321452 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863514 C[N+](C)(C)CCNS(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nnn[nH]2)c1S(N)(=O)=O InChI=1S/C19H24N9O4S3/c1-28(2,3)10-9-22-35(31,32)14-8-7-11(12-5-4-6-13-16(12)23-19(20)33-13)15(17(14)34(21,29)30)18-24-26-27-25-18/h4-8,22H,9-10H2,1-3H3,(H2,20,23)(H2,21,29,30)(H,24,25,26,27)/q+1 ZYNDVCSMOHTMPY-UHFFFAOYSA-N 427555 2-({[4-(2-amino-1,3- benzothiazol-4-yl)-2- sulfamoyl-3-(1H- tetrazol-5- yl)phenyl]sulfonyl} amino)-N,N,N- trimethylethanaminium trifluoroacetate::US10544130, Example 391 Metallo-beta-lactamase type 2 0.209 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=427555 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=427555&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 154732665 434317329 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863517 C[N+](C)(C)CCCNS(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nnn[nH]2)c1S(N)(=O)=O InChI=1S/C20H26N9O4S3/c1-29(2,3)11-5-10-23-36(32,33)15-9-8-12(13-6-4-7-14-17(13)24-20(21)34-14)16(18(15)35(22,30)31)19-25-27-28-26-19/h4,6-9,23H,5,10-11H2,1-3H3,(H2,21,24)(H2,22,30,31)(H,25,26,27,28)/q+1 SJTLDCMGGRCPJQ-UHFFFAOYSA-N 427556 3-({[4-(2-amino-1,3- benzothiazol-4-yl)-2- sulfamoyl-3-(1H- tetrazol-5- yl)phenyl]sulfonyl} amino)-N,N,N- trimethylpropan-1- amimum trifluoroacetate::US10544130, Example 392 Metallo-beta-lactamase type 2 0.221 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=427556 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=427556&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 154732666 434317330 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863520 C[C@H](CN)NS(=O)(=O)c1ccc(-c2ccc(N)nc2)c(-c2nn[nH]n2)c1S(N)(=O)=O 361236 (R)—N1-(1-aminopropan-2-yl)-4-(6-aminopyridin-3-yl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 393::US10544130, Example 393 Metallo-beta-lactamase type 2 0.063 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361236 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361236&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124158292 386400625 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863523 C[C@@H](CN)NS(=O)(=O)c1ccc(-c2ccc(N)nc2)c(-c2nn[nH]n2)c1S(N)(=O)=O 361237 US10221163, Example 394::US10544130, Example 394 Metallo-beta-lactamase type 2 2.00 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361237 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361237&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269280 386400626 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863526 C[C@H](CN)NS(=O)(=O)c1ccc(-c2cccc3n(C)c(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O 361238 US10221163, Example 395::US10544130, Example 395 Metallo-beta-lactamase type 2 0.156 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361238 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361238&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269281 386400627 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863529 C[C@H](CN)NS(=O)(=O)c1ccc(-c2cc(F)cc3[nH]c(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C17H17FN10O4S2/c1-7(6-19)26-34(31,32)12-3-2-9(10-4-8(18)5-11-14(10)23-17(20)22-11)13(15(12)33(21,29)30)16-24-27-28-25-16/h2-5,7,26H,6,19H2,1H3,(H2,20,22)(H2,21,29,30)/b10-9+/t7-/m1/s1 CNLLIMMZIIFSRY-KOUNZKNHSA-N 361239 US10221163, Example 396::US10544130, Example 396 Metallo-beta-lactamase type 2 0.221 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361239 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361239&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269282 386400628 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863532 C[C@@H](CN)NS(=O)(=O)c1ccc(-c2cc(F)cc3[nH]c(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C17H17FN10O4S2/c1-7(6-19)26-34(31,32)12-3-2-9(10-4-8(18)5-11-14(10)23-17(20)22-11)13(15(12)33(21,29)30)16-24-27-28-25-16/h2-5,7,26H,6,19H2,1H3,(H2,20,22)(H2,21,29,30)/b10-9+/t7-/m0/s1 CNLLIMMZIIFSRY-YLZOWGOUSA-N 361240 US10221163, Example 397::US10544130, Example 397 Metallo-beta-lactamase type 2 1.60 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361240 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361240&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269283 386400629 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863535 C[C@@H](CN)NS(=O)(=O)c1ccc(-c2ccnc(N)c2)c(-c2nn[nH]n2)c1S(N)(=O)=O 361241 US10221163, Example 398::US10544130, Example 398 Metallo-beta-lactamase type 2 7.45 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361241 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361241&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269284 386400630 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863538 Nc1nc2c(cc(F)cc2[nH]1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)N[C@H]1CCNC1 InChI=1S/C18H17FN10O4S2/c19-8-5-11(15-12(6-8)23-18(20)24-15)10-1-2-13(35(32,33)27-9-3-4-22-7-9)16(34(21,30)31)14(10)17-25-28-29-26-17/h1-2,5-6,9,22,27H,3-4,7H2,(H2,20,23)(H2,21,30,31)/b11-10+/t9-/m0/s1 SXTBYHWGGXCMBX-YHTNPHCKSA-N 361242 US10221163, Example 399::US10544130, Example 399 Metallo-beta-lactamase type 2 0.533 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361242 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361242&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 137537617 386400631 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863541 NCCNS(=O)(=O)c1ccc(-c2ccnc(N)c2)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C14H17N9O4S2/c15-4-6-19-29(26,27)10-2-1-9(8-3-5-18-11(16)7-8)12(13(10)28(17,24)25)14-20-22-23-21-14/h1-3,5,7,19H,4,6,15H2,(H2,16,18)(H2,17,24,25)(H,20,21,22,23) RRTXSFAFHOPSAU-UHFFFAOYSA-N 361243 US10221163, Example 400::US10544130, Example 400 Metallo-beta-lactamase type 2 1.42 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361243 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361243&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 137537559 386400632 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863544 NCCNS(=O)(=O)c1ccc(-c2ccc3nccn3c2)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C16H17N9O4S2/c17-5-6-20-31(28,29)12-3-2-11(10-1-4-13-19-7-8-25(13)9-10)14(15(12)30(18,26)27)16-21-23-24-22-16/h1-4,7-9,20H,5-6,17H2,(H2,18,26,27)(H,21,22,23,24) CAPREPJCVIJSJF-UHFFFAOYSA-N 361244 US10221163, Example 401::US10544130, Example 401 Metallo-beta-lactamase type 2 0.483 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361244 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361244&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 137537529 386400633 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863547 NCCCNS(=O)(=O)c1ccc(-c2cc(F)cc3[nH]c(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C17H19FN10O4S2/c18-8-6-10(14-11(7-8)23-17(20)24-14)9-2-3-12(34(31,32)22-5-1-4-19)15(33(21,29)30)13(9)16-25-27-28-26-16/h2-3,6-7,22H,1,4-5,19H2,(H3,20,23,24)(H2,21,29,30)(H,25,26,27,28) WWOWQFNSNPLLCR-UHFFFAOYSA-N 361245 US10221163, Example 402::US10544130, Example 402 Metallo-beta-lactamase type 2 0.318 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361245 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361245&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 137537710 386400634 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863550 NCC(CN)NS(=O)(=O)c1ccc(-c2cccc3[nH]nnc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C16H19N11O4S2/c17-6-8(7-18)24-33(30,31)12-5-4-9(10-2-1-3-11-14(10)21-25-20-11)13(15(12)32(19,28)29)16-22-26-27-23-16/h1-5,8,24H,6-7,17-18H2,(H2,19,28,29)(H,20,21,25)(H,22,23,26,27) AFJIDACMIUWLIM-UHFFFAOYSA-N 361246 US10221163, Example 403::US10544130, Example 403 Metallo-beta-lactamase type 2 0.531 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361246 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361246&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 137537717 386400635 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863553 NCC(CN)NS(=O)(=O)c1ccc(-c2ccc(N)nc2)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C15H20N10O4S2/c16-5-9(6-17)23-31(28,29)11-3-2-10(8-1-4-12(18)20-7-8)13(14(11)30(19,26)27)15-21-24-25-22-15/h1-4,7,9,23H,5-6,16-17H2,(H2,18,20)(H2,19,26,27)(H,21,22,24,25) XONJRNLITDZUPT-UHFFFAOYSA-N 361247 US10221163, Example 404::US10544130, Example 404 Metallo-beta-lactamase type 2 0.354 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361247 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361247&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 137537526 386400636 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863556 NCC(CN)NS(=O)(=O)c1ccc(-c2ccnc(N)c2)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C15H20N10O4S2/c16-6-9(7-17)23-31(28,29)11-2-1-10(8-3-4-20-12(18)5-8)13(14(11)30(19,26)27)15-21-24-25-22-15/h1-5,9,23H,6-7,16-17H2,(H2,18,20)(H2,19,26,27)(H,21,22,24,25) JWVIACWDXBAAGB-UHFFFAOYSA-N 361248 US10221163, Example 405::US10544130, Example 405 Metallo-beta-lactamase type 2 17.9 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361248 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361248&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 137537711 386400637 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863559 NCC(CN)NS(=O)(=O)c1ccc(-c2ccc3nccn3c2)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C17H20N10O4S2/c18-7-11(8-19)24-33(30,31)13-3-2-12(10-1-4-14-21-5-6-27(14)9-10)15(16(13)32(20,28)29)17-22-25-26-23-17/h1-6,9,11,24H,7-8,18-19H2,(H2,20,28,29)(H,22,23,25,26) HEXNYHIYGROCAJ-UHFFFAOYSA-N 361249 US10221163, Example 406::US10544130, Example 406 Metallo-beta-lactamase type 2 0.592 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361249 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361249&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 137537625 386400638 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863562 NC[C@H](CO)NS(=O)(=O)c1ccc(-c2cccc3[nH]nnc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C16H16N10O5S2/c17-6-8(7-27)23-33(30,31)12-5-4-9(10-2-1-3-11-14(10)20-24-19-11)13(15(12)32(18,28)29)16-21-25-26-22-16/h1-5,8,23,27H,6-7,17H2,(H2,18,28,29)/b10-9+/t8-/m1/s1 BSOALSPTRJCYFY-KGSKPCQNSA-N 361250 US10221163, Example 407::US10544130, Example 407 Metallo-beta-lactamase type 2 1.35 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361250 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361250&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 137537614 386400639 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863565 NC[C@H](CO)NS(=O)(=O)c1ccc(-c2ccc(N)nc2)c(-c2nn[nH]n2)c1S(N)(=O)=O 361251 US10221163, Example 408::US10544130, Example 408 Metallo-beta-lactamase type 2 0.684 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361251 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361251&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 137537599 386400640 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863568 NC[C@@H](CO)NS(=O)(=O)c1ccc(-c2ccc(N)nc2)c(-c2nn[nH]n2)c1S(N)(=O)=O 361252 US10221163, Example 409::US10544130, Example 409 Metallo-beta-lactamase type 2 0.170 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361252 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361252&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 137537557 386400641 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863571 Nc1ccc(cn1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)N[C@H]1CNC[C@H]1O 361253 US10221163, Example 410::US10544130, Example 410 Metallo-beta-lactamase type 2 0.681 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361253 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361253&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 137537698 386400642 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862596 COc1ccc(CN(Cc2ccc(OC)cc2)S(=O)(=O)c2c(ccc(I)c2-c2nnn(Cc3ccc(OC)cc3)n2)S(=O)(=O)NC(CNC(=O)OC(C)(C)C)CNC(=O)OC(C)(C)C)cc1 InChI=1S/C44H55IN8O11S2/c1-43(2,3)63-41(54)46-24-32(25-47-42(55)64-44(4,5)6)50-65(56,57)37-23-22-36(45)38(40-48-51-53(49-40)28-31-14-20-35(62-9)21-15-31)39(37)66(58,59)52(26-29-10-16-33(60-7)17-11-29)27-30-12-18-34(61-8)19-13-30/h10-23,32,50H,24-28H2,1-9H3,(H,46,54)(H,47,55) QVKQWKSQEZEBGV-UHFFFAOYSA-N 360928 US10221163, Example 84::US10544130, Example 84::di-tert-butyl (2-(2-(N,N-bis(4- methoxybenzyl)sulfamoyl)-4- iodo-3-(2-(4-methoxybenzyl)- 2H-tetrazol-5- yl)phenylsulfonamido)propane- 1,3-diyl)dicarbamate Metallo-beta-lactamase type 2 0.403 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360928 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360928&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311148 386400321 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862599 COc1ccc(CN(Cc2ccc(OC)cc2)S(=O)(=O)c2c(ccc(I)c2-c2nnn(Cc3ccc(OC)cc3)n2)S(=O)(=O)NC[C@H](CNC(=O)OC(C)(C)C)NC(=O)OCc2ccccc2)cc1 InChI=1S/C47H53IN8O11S2/c1-47(2,3)67-45(57)49-26-36(51-46(58)66-31-35-10-8-7-9-11-35)27-50-68(59,60)41-25-24-40(48)42(44-52-54-56(53-44)30-34-16-22-39(65-6)23-17-34)43(41)69(61,62)55(28-32-12-18-37(63-4)19-13-32)29-33-14-20-38(64-5)21-15-33/h7-25,36,50H,26-31H2,1-6H3,(H,49,57)(H,51,58)/t36-/m0/s1 KCNOJKKSHLOHOR-BHVANESWSA-N 427141 US10544130, Example 85::benzyl tert-butyl (3-((2-(N,N- bis(4-methoxybenzyl)sulfamoyl)- 4-iodo-3-(2-(4-methoxybenzyl)- 2H-tetrazol-5- yl)phenyl)sulfonamido)propane- 1,2-diyl)(S)-dicarbamate Metallo-beta-lactamase type 2 0.205 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=427141 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=427141&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 154732992 434321455 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862602 Nc1nc2c(cccc2s1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)NCC1(O)CCNCC1 InChI=1S/C20H23N9O5S3/c21-19-25-16-12(2-1-3-13(16)35-19)11-4-5-14(17(36(22,31)32)15(11)18-26-28-29-27-18)37(33,34)24-10-20(30)6-8-23-9-7-20/h1-5,23-24,30H,6-10H2,(H2,21,25)(H2,22,31,32)(H,26,27,28,29) LHGHDVNQBZMSRJ-UHFFFAOYSA-N 360930 4-(2- aminobenzo [d]thiazol- 4-yl)-N1-((4- hydroxypiperidin- 4-yl)methyl)- 3-(1H- tetrazol-5-yl) benzene-1,2- disulfonamide::US10221163, Example 86::US10544130, Example 86 Metallo-beta-lactamase type 2 0.129 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360930 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360930&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311714 386400323 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862605 CC(C)(N)CNS(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nnn[nH]2)c1S(N)(=O)=O InChI=1S/C18H21N9O4S3/c1-18(2,20)8-22-34(30,31)12-7-6-9(10-4-3-5-11-14(10)23-17(19)32-11)13(15(12)33(21,28)29)16-24-26-27-25-16/h3-7,22H,8,20H2,1-2H3,(H2,19,23)(H2,21,28,29)(H,24,25,26,27) LDXPTSONMCDLJU-UHFFFAOYSA-N 360931 N1-(2-amino-2- methylpropyl)- 4-(2-aminobenzo [d]thiazol- 4-yl)-3-(1H- tetrazol-5- yl)benzene-1,2- disulfonamide::US10221163, Example 87::US10544130, Example 87 Metallo-beta-lactamase type 2 0.261 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360931 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360931&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135312016 386400324 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862608 Nc1nc2c(cccc2s1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)NC1CC2CNC1C2 360932 4-(2-aminobenzo [d]thiazol-4-yl)- N1-(2-azabicyclo [2.2.1]heptan- 6-yl)-3-(1H- tetrazol-5- yl)benzene-1,2- disulfonamide::US10221163, Example 88::US10221163, Example 89::US10544130, Example 89 Metallo-beta-lactamase type 2 0.172 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360932 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360932&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311710 386400325 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862611 Nc1nc2c(cccc2s1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)NC1CC2CNC1C2 360932 4-(2-aminobenzo [d]thiazol-4-yl)- N1-(2-azabicyclo [2.2.1]heptan- 6-yl)-3-(1H- tetrazol-5- yl)benzene-1,2- disulfonamide::US10221163, Example 88::US10221163, Example 89::US10544130, Example 89 Metallo-beta-lactamase type 2 0.568 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360932 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360932&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311710 386400325 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862614 NCCCNS(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nnn[nH]2)c1S(N)(=O)=O InChI=1S/C17H19N9O4S3/c18-7-2-8-21-33(29,30)12-6-5-9(10-3-1-4-11-14(10)22-17(19)31-11)13(15(12)32(20,27)28)16-23-25-26-24-16/h1,3-6,21H,2,7-8,18H2,(H2,19,22)(H2,20,27,28)(H,23,24,25,26) CRRHXDQIJGYZET-UHFFFAOYSA-N 360934 3-(4-(2- aminobenzo [d]thiazol-4-yl)- 2-sulfamoyl-3- (1H-tetrazol-5- yl)phenyl- sulfonamido) propan-1- aminium 2,2,2- trifluoroacetate::US10221163, Example 90::US10544130, Example 90 Metallo-beta-lactamase type 2 0.411 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360934 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360934&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311755 386400326 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862617 Nc1nc2c(cccc2s1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)NCC1(F)CNC1 InChI=1S/C18H18FN9O4S3/c19-18(6-22-7-18)8-23-35(31,32)12-5-4-9(10-2-1-3-11-14(10)24-17(20)33-11)13(15(12)34(21,29)30)16-25-27-28-26-16/h1-5,22-23H,6-8H2,(H2,20,24)(H2,21,29,30)(H,25,26,27,28) FBOXLDIWBOPBGH-UHFFFAOYSA-N 360890 4-(2-amino-1,3- benzothiazol-4-yl)-N1-[(3- fluoroazetidin-3- yl)methyl]-3-(1H-tetrazol- 5-yl)benzene-1,2- disulfonamide::US10221163, Example 46::US10221163, Example 91::US10544130, Example 91 Metallo-beta-lactamase type 2 0.326 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360890 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360890&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311332 386400283 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862620 Nc1nc2c(cccc2s1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)N1CCN(CCO)CC1 InChI=1S/C20H23N9O5S3/c21-20-23-17-13(2-1-3-14(17)35-20)12-4-5-15(18(36(22,31)32)16(12)19-24-26-27-25-19)37(33,34)29-8-6-28(7-9-29)10-11-30/h1-5,30H,6-11H2,(H2,21,23)(H2,22,31,32)(H,24,25,26,27) ASHSVVZOBGBBQZ-UHFFFAOYSA-N 360936 4-((4-(2- aminobenzo [d]thiazol-4-yl)-2- sulfamoyl-3- (1H-tetrazol-3- yl)phenyl) sulfonyl)-1-(2- hydroxyethyl) piperazin- 1-ium 2,2,2- trifluoroacetate::US10221163, Example 92::US10544130, Example 92 Metallo-beta-lactamase type 2 1.17 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360936 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360936&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 137537573 386400327 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862623 CNCCCN(C)S(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nnn[nH]2)c1S(N)(=O)=O InChI=1S/C19H23N9O4S3/c1-22-9-4-10-28(2)35(31,32)14-8-7-11(12-5-3-6-13-16(12)23-19(20)33-13)15(17(14)34(21,29)30)18-24-26-27-25-18/h3,5-8,22H,4,9-10H2,1-2H3,(H2,20,23)(H2,21,29,30)(H,24,25,26,27) NZHSSFSFHRZHMS-UHFFFAOYSA-N 427151 3-(4-(2- aminobenzo[d]thiazol- 4-yl)-N-methyl-2- sulfamoyl-3-(1H- tetrazol-5-yl) phenylsulfonamido)- N-methylpropan-1- aminium 2,2,2- trifluoroacetate::US10544130, Example 93 Metallo-beta-lactamase type 2 5.29 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=427151 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=427151&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311182 434321465 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862626 NC[C@@H]1CCN(C1)S(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nnn[nH]2)c1S(N)(=O)=O 360914 3-(2-amino-1,3- benzothiazol-4-yl)-6- {[(3S)-3- (aminomethyl)pyrrolidin- 1-yl]sulfonyl}-2-(1H- tetrazol-5- yl)benzenesulfonamide::US10221163, Example 70::US10221163, Example 94::US10544130, Example 94 Metallo-beta-lactamase type 2 0.730 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360914 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360914&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311199 386400307 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862629 NC1CC2OC1CCC2NS(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nnn[nH]2)c1S(N)(=O)=O 360939 2-(4-(2- aminobenzo [d]thiazol-4-yl)-2- sulfamoyl-3- (1H-tetrazol-5- yl)phenyl- sulfonamido)-8- oxabicyclo[3.2.1] octan-6-aminium 2,2,2- trifluoroacetate::US10221163, Example 95::US10544130, Example 95 Metallo-beta-lactamase type 2 0.193 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360939 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360939&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135310742 386400329 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862632 Nc1nc2c(cccc2s1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)NCC1COCCN1 360940 3-((4-(2- aminobenzo [d]thiazol-4-yl)-2- sulfamoyl-3- (1H-tetrazol-5-yl) phenylsulfonamido) methyl)morpholin-4- ium 2,2,2- trifluoroacetate::US10221163, Example 96::US10544130, Example 96 Metallo-beta-lactamase type 2 0.402 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360940 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360940&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311727 386400330 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862635 Nc1nc2c(cccc2s1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)NC1CN2CCC1CC2 360941 3-(4-(2-amino- benzo[d]thiazol- 4-yl)-2-sulfamoyl-3- (1H-tetrazol-5-yl) phenylsulfonamido) quinuclidin- 1-ium 2,2,2- trifluoroacetate::US10221163, Example 97::US10544130, Example 97 Metallo-beta-lactamase type 2 0.383 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360941 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360941&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135310915 386400331 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862638 N[C@H]1C[C@@H](C1)NS(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nnn[nH]2)c1S(N)(=O)=O 360915 4-(2-amino-1,3- benzothiazol-4-yl)-N1- (trans-3-aminocyclobutyl)- 3-(1H-tetrazol-5- yl)benzene-1,2- disulfonamide::US10221163, Example 71::US10544130, Example 98 Metallo-beta-lactamase type 2 0.209 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360915 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360915&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311334 386400308 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862641 N[C@H](NS(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nnn[nH]2)c1S(N)(=O)=O)c1ccccn1 360943 (R)-(4-(2- aminobenzo [d]thiazol-4-yl)-2- sulfamoyl-3-(1H- tetrazol-5-yl) phenylsulfonamido) (pyridin-2-yl) methanaminium 2,2,2- trifluoroacetate::US10221163, Example 99::US10544130, Example 99 Metallo-beta-lactamase type 2 0.566 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360943 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360943&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269199 386400333 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862644 CN(CCc1ccncc1)S(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nnn[nH]2)c1S(N)(=O)=O InChI=1S/C22H21N9O4S3/c1-31(12-9-13-7-10-25-11-8-13)38(34,35)17-6-5-14(15-3-2-4-16-19(15)26-22(23)36-16)18(20(17)37(24,32)33)21-27-29-30-28-21/h2-8,10-11H,9,12H2,1H3,(H2,23,26)(H2,24,32,33)(H,27,28,29,30) UMNPTGPXWSXOOY-UHFFFAOYSA-N 360944 4-(2-(4-(2- aminobenzo[d] thiazol-4-yl)-N- methyl-2-sulfamoyl- 3-(1H-tetrazol-5- yl)phenyl- sulfonamido) ethyl)pyridin- 1-ium 2,2,2- trifluoroacetate::US10221163, Example 100::US10544130, Example 100 Metallo-beta-lactamase type 2 3.26 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360944 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360944&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269200 386400334 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862647 CC1(CN)CN(C1)S(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nnn[nH]2)c1S(N)(=O)=O InChI=1S/C19H21N9O4S3/c1-19(7-20)8-28(9-19)35(31,32)13-6-5-10(11-3-2-4-12-15(11)23-18(21)33-12)14(16(13)34(22,29)30)17-24-26-27-25-17/h2-6H,7-9,20H2,1H3,(H2,21,23)(H2,22,29,30)(H,24,25,26,27) ZWPMTWURJWGRPP-UHFFFAOYSA-N 360945 (1-((4-(2- aminobenzo [d]thiazol-4-yl)-2- sulfamoyl-3-(1H- tetrazol-5-yl)phenyl) sulfonyl)-3- methylazetidin- 3-yl) methanaminium 2,2,2- trifluoroacetate::US10221163, Example 101::US10544130, Example 101 Metallo-beta-lactamase type 2 1.25 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360945 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360945&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311100 386400335 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862650 CN1CCC(CNS(=O)(=O)c2ccc(-c3cccc4sc(N)nc34)c(-c3nnn[nH]3)c2S(N)(=O)=O)C1 360946 3-((4-(2- aminobenzo [d]thiazol-4-yl)-2- sulfamoyl-3- (1H-tetrazol-5-yl) phenylsulfonamido) methyl)-1- methylpyrrolidin- 1-ium 2,2,2- trifluoroacetate::US10221163, Example 102::US10544130, Example 102 Metallo-beta-lactamase type 2 0.263 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360946 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360946&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311988 386400336 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862653 N[C@@H]1CO[C@@H]2[C@H](CO[C@H]12)NS(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nnn[nH]2)c1S(N)(=O)=O 360947 (3R,3aR, 6S,6aR)-6-(4-(2- aminobenzo[d] thiazol-4-yl)-2- sulfamoyl-3-(1H- tetrazol-5-yl)phenyl- sulfonamido) hexahydrofuro[3,2- b]furan-3-aminium 2,2,2- trifluoroacetate::US10221163, Example 103::US10544130, Example 103 Metallo-beta-lactamase type 2 0.226 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360947 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360947&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 137537510 386400337 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862656 NCC1CN(CCO1)S(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nnn[nH]2)c1S(N)(=O)=O 360948 (4-((4-(2- aminobenzo[d] thiazol-4-yl)-2- sulfamoyl-3- (1H-tetrazol-5-yl) phenyl)sulfonyl) morpholin-2-yl) methanaminium 2,2,2- trifluoroacetate::US10221163, Example 104::US10544130, Example 104 Metallo-beta-lactamase type 2 1.24 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360948 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360948&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135310981 386400338 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863574 Nc1ccc(cn1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)N[C@H]1CN[C@H](CO)C1 361254 US10221163, Example 411::US10544130, Example 411 Metallo-beta-lactamase type 2 0.408 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361254 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361254&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 137537607 386400643 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863577 NS(=O)(=O)c1c(ccc(-c2cccc3[nH]nnc23)c1-c1nn[nH]n1)S(=O)(=O)N[C@@H]1CNC[C@@H]1O InChI=1S/C17H16N10O5S2/c18-33(29,30)16-13(34(31,32)24-11-6-19-7-12(11)28)5-4-8(14(16)17-22-26-27-23-17)9-2-1-3-10-15(9)21-25-20-10/h1-5,11-12,19,24,28H,6-7H2,(H2,18,29,30)/b9-8+/t11-,12+/m1/s1 YGUFCTKAWQOGPA-DGTDAXKGSA-N 361255 US10221163, Example 412::US10544130, Example 412 Metallo-beta-lactamase type 2 2.57 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361255 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361255&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 137537561 386400644 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863580 N[C@@H]1CNC[C@@H]1NS(=O)(=O)c1ccc(-c2ccc(N)nc2)c(-c2nn[nH]n2)c1S(N)(=O)=O 361256 US10221163, Example 413::US10544130, Example 413 Metallo-beta-lactamase type 2 0.800 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361256 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361256&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 137537608 386400645 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863583 N[C@H]1CNC[C@H]1NS(=O)(=O)c1ccc(-c2ccc(N)nc2)c(-c2nn[nH]n2)c1S(N)(=O)=O 427578 US10544130, Example 414 Metallo-beta-lactamase type 2 0.786 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=427578 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=427578&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 154732676 434317352 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863586 NC[C@H](N)CNS(=O)(=O)c1ccc(-c2ccc(N)nc2)c(-c2nn[nH]n2)c1S(N)(=O)=O 361258 US10221163, Example 415::US10544130, Example 415 Metallo-beta-lactamase type 2 0.801 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361258 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361258&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 137537591 386400647 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863589 NC[C@@H](N)CNS(=O)(=O)c1ccc(-c2ccc(N)nc2)c(-c2nn[nH]n2)c1S(N)(=O)=O 361259 US10221163, Example 416::US10544130, Example 416 Metallo-beta-lactamase type 2 1.34 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361259 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361259&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 137537592 386400648 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863592 NC[C@H](O)CNS(=O)(=O)c1ccc(-c2ccnc(N)c2)c(-c2nn[nH]n2)c1S(N)(=O)=O 427581 US10544130, Example 417 Metallo-beta-lactamase type 2 1.28 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=427581 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=427581&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 154732677 434317355 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863595 NC[C@H](O)CNS(=O)(=O)c1ccc(-c2ccc3nccn3c2)c(-c2nn[nH]n2)c1S(N)(=O)=O 361261 US10221163, Example 418::US10544130, Example 418 Metallo-beta-lactamase type 2 0.834 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361261 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361261&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 137537719 386400650 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863598 NC[C@@H](O)CNS(=O)(=O)c1ccc(-c2ccnc(N)c2)c(-c2nn[nH]n2)c1S(N)(=O)=O 361262 US10221163, Example 419::US10544130, Example 419 Metallo-beta-lactamase type 2 1.51 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361262 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361262&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 137537606 386400651 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863601 NC[C@@H](O)CNS(=O)(=O)c1ccc(-c2ccc3nccn3c2)c(-c2nn[nH]n2)c1S(N)(=O)=O 361263 US10221163, Example 420::US10544130, Example 420 Metallo-beta-lactamase type 2 0.974 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361263 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361263&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 137537530 386400652 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863604 C[C@H](N)CNS(=O)(=O)c1ccc(-c2ccnc(N)c2)c(-c2nn[nH]n2)c1S(N)(=O)=O 361264 US10221163, Example 421::US10544130, Example 421 Metallo-beta-lactamase type 2 1.14 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361264 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361264&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 137537528 386400653 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863607 C[C@@H](N)CNS(=O)(=O)c1ccc(-c2ccnc(N)c2)c(-c2nn[nH]n2)c1S(N)(=O)=O 361265 US10221163, Example 422::US10544130, Example 422 Metallo-beta-lactamase type 2 0.982 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361265 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361265&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 137537609 386400654 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863610 C[C@@H](N)CNS(=O)(=O)c1ccc(-c2ccc3nccn3c2)c(-c2nn[nH]n2)c1S(N)(=O)=O 361266 US10221163, Example 423::US10544130, Example 423 Metallo-beta-lactamase type 2 1.15 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361266 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361266&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 137537532 386400655 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863613 N[C@@H]1CNC[C@H]1NS(=O)(=O)c1ccc(-c2cccc3[nH]c(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C18H19N11O4S2/c19-10-6-22-7-12(10)27-35(32,33)13-5-4-8(9-2-1-3-11-15(9)24-18(20)23-11)14(16(13)34(21,30)31)17-25-28-29-26-17/h1-5,10,12,22,27H,6-7,19H2,(H2,20,23)(H2,21,30,31)/b9-8+/t10-,12-/m1/s1 LIRUKQKKERNVIK-VCXMCINHSA-N 361165 4-(2-Amino-1H-benzo[d]imidazol-4-yl)-N1-((3S,4R)-4-aminopyrrolidin-3-yl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 322::US10221163, Example 424::US10544130, Example 424 Metallo-beta-lactamase type 2 0.814 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361165 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361165&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269246 386400555 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863616 NC[C@@H]1C[C@H](CN1)NS(=O)(=O)c1ccc(-c2cccc3[nH]c(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C19H21N11O4S2/c20-7-9-6-10(8-23-9)28-36(33,34)14-5-4-11(12-2-1-3-13-16(12)25-19(21)24-13)15(17(14)35(22,31)32)18-26-29-30-27-18/h1-5,9-10,23,28H,6-8,20H2,(H2,21,24)(H2,22,31,32)/b12-11+/t9-,10+/m0/s1 KTMUYXQVZSGHIU-XXQWGACESA-N 361268 4-(2-amino-1H-benzo[d]imidazol-4-yl)-N1-((3R,5S)-5-(aminomethyl)pyrrolidin-3-yl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 425::US10544130, Example 425 Metallo-beta-lactamase type 2 0.886 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361268 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361268&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311876 386400656 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863619 NCC(CO)NS(=O)(=O)c1ccc(-c2cccc3[nH]c(N)nc23)c(-c2nnn[nH]2)c1S(N)(=O)=O InChI=1S/C17H18N10O5S2/c18-6-8(7-28)25-34(31,32)12-5-4-9(10-2-1-3-11-14(10)22-17(19)21-11)13(15(12)33(20,29)30)16-23-26-27-24-16/h1-5,8,25,28H,6-7,18H2,(H2,19,21)(H2,20,29,30)/b10-9+ KAGPCWFBBKVWMA-MDZDMXLPSA-N 361269 (S)-4-(2-Amino-1H-benzo[d]imidazol-4-yl)-N1-(1-amino-3-hydroxypropan-2-yl)-3-(1H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 426::US10544130, Example 426 Metallo-beta-lactamase type 2 0.273 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361269 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361269&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269285 386400657 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863622 NC[C@H](CO)NS(=O)(=O)c1ccc(-c2cccc3nc(N)[nH]c23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C17H18N10O5S2/c18-6-8(7-28)25-34(31,32)12-5-4-9(10-2-1-3-11-14(10)22-17(19)21-11)13(15(12)33(20,29)30)16-23-26-27-24-16/h1-5,8,25,28H,6-7,18H2,(H2,19,21)(H2,20,29,30)/b10-9+/t8-/m1/s1 KAGPCWFBBKVWMA-KGSKPCQNSA-N 361270 US10221163, Example 427::US10544130, Example 427 Metallo-beta-lactamase type 2 2.61 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361270 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361270&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 137537601 386400658 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863625 Nc1nc(c[nH]1)-c1cccc(c1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)N[C@@H]1CCNC1 361271 US10221163, Example 428::US10544130, Example 428 Metallo-beta-lactamase type 2 0.407 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361271 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361271&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269286 386400659 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863628 NCC(CN)NS(=O)(=O)c1ccc(-c2cccc3[nH]c(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C17H21N11O4S2/c18-6-8(7-19)26-34(31,32)12-5-4-9(10-2-1-3-11-14(10)23-17(20)22-11)13(15(12)33(21,29)30)16-24-27-28-25-16/h1-5,8,26H,6-7,18-19H2,(H3,20,22,23)(H2,21,29,30)(H,24,25,27,28) CXSKGFQNMGEJNL-UHFFFAOYSA-N 361272 US10221163, Example 429::US10544130, Example 429 Metallo-beta-lactamase type 2 0.489 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361272 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361272&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 137537628 386400660 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863631 NCC(CN)NS(=O)(=O)c1ccc(-c2cccc3ccc(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C19H22N10O4S2/c20-8-11(9-21)27-35(32,33)14-6-5-12(13-3-1-2-10-4-7-15(22)24-17(10)13)16(18(14)34(23,30)31)19-25-28-29-26-19/h1-7,11,27H,8-9,20-21H2,(H2,22,24)(H2,23,30,31)(H,25,26,28,29) CLEQRMCQLNNGRY-UHFFFAOYSA-N 361273 US10221163, Example 430::US10544130, Example 430 Metallo-beta-lactamase type 2 0.102 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361273 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361273&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 137537716 386400661 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862659 CN(C1CNC1)S(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nnn[nH]2)c1S(N)(=O)=O InChI=1S/C18H19N9O4S3/c1-27(9-7-21-8-9)34(30,31)13-6-5-10(11-3-2-4-12-15(11)22-18(19)32-12)14(16(13)33(20,28)29)17-23-25-26-24-17/h2-6,9,21H,7-8H2,1H3,(H2,19,22)(H2,20,28,29)(H,23,24,25,26) AYUSQLJTKXUKDZ-UHFFFAOYSA-N 360949 3-(4-(2- aminobenzo[d] thiazol-4-yl)-N- methyl-2-sulfamoyl- 3-(1H-tetrazol-5-yl) phenylsulfonamido) azetidin-1-ium 2,2,2- trifluoroacetate::US10221163, Example 105::US10544130, Example 105 Metallo-beta-lactamase type 2 1.18 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360949 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360949&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311037 386400339 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862662 Nc1nc2c(cccc2s1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)NCc1ccccn1 InChI=1S/C20H17N9O4S3/c21-20-25-17-13(5-3-6-14(17)34-20)12-7-8-15(36(32,33)24-10-11-4-1-2-9-23-11)18(35(22,30)31)16(12)19-26-28-29-27-19/h1-9,24H,10H2,(H2,21,25)(H2,22,30,31)(H,26,27,28,29) CUZJLQPCENXUCT-UHFFFAOYSA-N 360950 2-((4-(2- aminobenzo [d]thiazol-4-yl)- 2-sulfamoyl-3- (1H-tetrazol-5-yl) phenylsulfonamido) methyl)pyridin-1-ium 2,2,2- trifluoroacetate::US10221163, Example 106::US10544130, Example 106 Metallo-beta-lactamase type 2 0.379 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360950 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360950&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269201 386400340 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862665 CN(C1CN(C)C1)S(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nnn[nH]2)c1S(N)(=O)=O InChI=1S/C19H21N9O4S3/c1-27-8-10(9-27)28(2)35(31,32)14-7-6-11(12-4-3-5-13-16(12)22-19(20)33-13)15(17(14)34(21,29)30)18-23-25-26-24-18/h3-7,10H,8-9H2,1-2H3,(H2,20,22)(H2,21,29,30)(H,23,24,25,26) VEXYMHUJQMBNMQ-UHFFFAOYSA-N 360951 3-(4-(2- aminobenzo [d]thiazol-4-yl)-N- methyl-2-sulfamoyl- 3-(1H-tetrazol-5-yl) phenylsulfonamido)- 1-methylazetidin- 1-ium 2,2,2- trifluoroacetate::US10221163, Example 107::US10544130, Example 107 Metallo-beta-lactamase type 2 1.40 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360951 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360951&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311515 386400341 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862668 CO[C@H]1CNC[C@@H]1NS(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nnn[nH]2)c1S(N)(=O)=O 360952 (3S,4S)-3-(4-(2- aminobenzo[d] thiazol-4-yl)-2- sulfamoyl-3- (1H-tetrazol-5-yl) phenylsulfonamido)- 4-methoxypyrrolidin- 1-ium 2,2,2- trifluoroacetate::US10221163, Example 108::US10544130, Example 108 Metallo-beta-lactamase type 2 0.336 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360952 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360952&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311185 386400342 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862671 CC(N)CNS(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nnn[nH]2)c1S(N)(=O)=O 360953 1-(4-(2- aminobenzo[d] thiazol-4-yl)-2- sulfamoyl-3-(1H- tetrazol-5-yl)phenyl- sulfonamido) propan-2-aminium 2,2,2- trifluoroacetate::US10221163, Example 109::US10544130, Example 109 Metallo-beta-lactamase type 2 0.440 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360953 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360953&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135310971 386400343 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862674 NCC1CCCCN1S(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nnn[nH]2)c1S(N)(=O)=O 360954 (1-((4-(2- aminobenzo[d] thiazol-4-yl)-2- sulfamoyl-3-(1H- tetrazol-5-yl)phenyl) sulfonyl)piperidin-2- yl)methanaminium 2,2,2- trifluoroacetate::US10221163, Example 110::US10544130, Example 110 Metallo-beta-lactamase type 2 0.346 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360954 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360954&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135310930 386400344 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862677 Nc1nc2c(cccc2s1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)NC1C2CNCC12 360955 6-(4-(2- aminobenzo[d] thiazol-4-yl)-2- sulfamoyl-3-(1H- tetrazol-5-yl)phenyl- sulfonamido)-3- azabicyclo[3.1.0] hexan-3-ium 2,2,2- trifluoroacetate::US10221163, Example 111::US10544130, Example 111 Metallo-beta-lactamase type 2 0.429 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360955 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360955&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311089 386400345 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862680 Nc1nc2c(cccc2s1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)NCC1CNCCO1 360956 2-((4-(2- aminobenzo [d]thiazol-4-yl)-2- sulfamoyl-3-(1H- tetrazol-5-yl)phenyl- sulfonamido)methyl) morpholin-4-ium 2,2,2- trifluoroacetate::US10221163, Example 112::US10544130, Example 112 Metallo-beta-lactamase type 2 0.318 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360956 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360956&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311656 386400346 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862683 NC1C2CN(CC12)S(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nnn[nH]2)c1S(N)(=O)=O 360957 (1R,5S,6s)-3-((4-(2- aminobenzo[d] thiazol-4-yl)-2- sulfamoyl-3-(1H- tetrazol-5-yl)phenyl) sulfonyl)-3-aza- bicyclo[3.1.0]hexan- 6-aminium 2,2,2- trifluoroacetate::US10221163, Example 113::US10544130, Example 113 Metallo-beta-lactamase type 2 1.12 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360957 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360957&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 137537541 386400347 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862686 Nc1nc2c(cccc2s1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)NCC1(N)CCOC1 360958 3-((4-(2- aminobenzo [d]thiazol-4-yl)-2- sulfamoyl-3-(1H- tetrazol-5-yl)phenyl- sulfonamido)methyl) tetrahydrofuran- 3-aminium formate::US10221163, Example 114::US10544130, Example 114 Metallo-beta-lactamase type 2 0.298 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360958 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360958&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311282 386400348 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862689 Nc1nc2c(cccc2s1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)NCC1(N)CCOCC1 InChI=1S/C20H23N9O5S3/c21-19-25-16-12(2-1-3-13(16)35-19)11-4-5-14(17(36(23,30)31)15(11)18-26-28-29-27-18)37(32,33)24-10-20(22)6-8-34-9-7-20/h1-5,24H,6-10,22H2,(H2,21,25)(H2,23,30,31)(H,26,27,28,29) RPFSQALYXQGHSI-UHFFFAOYSA-N 360959 4-((4-(2- aminobenzo[d] thiazol-4-yl)-2- sulfamoyl-3-(1H- tetrazol-5-yl)phenyl- sulfonamido)methyl) tetrahydro-2H- pyran-4-aminium formate::US10221163, Example 115::US10544130, Example 115 Metallo-beta-lactamase type 2 0.324 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360959 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360959&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311956 386400349 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862692 CC(CN)NS(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nnn[nH]2)c1S(N)(=O)=O 360960 2-(4-(2- aminobenzo[d] thiazol-4-yl)-2- sulfamoyl-3-(1H- tetrazol-5-yl)phenyl- sulfonamido)propan- 1-aminium formate::US10221163, Example 116::US10544130, Example 116 Metallo-beta-lactamase type 2 0.267 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360960 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360960&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135310997 386400350 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862695 CC(C)(CN)NS(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nnn[nH]2)c1S(N)(=O)=O InChI=1S/C18H21N9O4S3/c1-18(2,8-19)25-34(30,31)12-7-6-9(10-4-3-5-11-14(10)22-17(20)32-11)13(15(12)33(21,28)29)16-23-26-27-24-16/h3-7,25H,8,19H2,1-2H3,(H2,20,22)(H2,21,28,29)(H,23,24,26,27) QJGBZMFDMGHLPK-UHFFFAOYSA-N 360961 2-(4-(2- aminobenzo[d] thiazol-4-yl)-2- sulfamoyl-3-(1H- tetrazol-5-yl)phenyl- sulfonamido)-2- methylpropan-1- aminium formate::US10221163, Example 117::US10544130, Example 117 Metallo-beta-lactamase type 2 0.243 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360961 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360961&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135310670 386400351 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862698 NC(CNS(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nnn[nH]2)c1S(N)(=O)=O)C(F)F 360962 3-(4-(2-aminobenzo [d]thiazol-4-yl)-2- sulfamoyl-3-(1H- tetrazol-5-yl)phenyl- sulfonamido)-1,1- difluoropropan-2- aminium formate::US10221163, Example 118::US10544130, Example 118 Metallo-beta-lactamase type 2 0.331 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360962 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360962&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311143 386400352 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862701 Nc1nc2c(cccc2s1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)NC1C[C@@H]2CN[C@H]1C2 360963 4-(2-aminobenzo [d[thiazol-4-yl)-N1- ((1S,4R)-2-azabicyclo [2.2.1]heptan-6-yl)- 3-(1H-tetrazol-5- yl)benzene-1,2- disulfonamide, formate salt::US10221163, Example 119::US10544130, Example 119 Metallo-beta-lactamase type 2 0.223 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360963 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360963&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311742 386400353 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862704 Nc1nc2c(cccc2s1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)NCC1CCNC1 360964 3-((4-(2-aminobenzo [d]thiazol-4-yl)-2- sulfamoyl-3-(1H- tetrazol-5-yl)phenyl- sulfonamido)methyl) pyrrolidin-1-ium formate::US10221163, Example 120::US10544130, Example 120 Metallo-beta-lactamase type 2 0.258 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360964 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360964&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311231 386400354 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862707 CN(C[C@@H]1CCCN1)S(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nnn[nH]2)c1S(N)(=O)=O 360965 (S)-2-((4-(2- aminobenzo[d] thiazol-4-yl)-N- methyl-2-sulfamoyl- 3-(1H-tetrazol-5-yl) phenylsulfonamido) methyl)pyrrolidin-1- ium formate::US10221163, Example 121::US10544130, Example 121 Metallo-beta-lactamase type 2 2.84 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360965 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360965&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311062 386400355 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862710 Nc1nc2c(cccc2s1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)NC[C@]1(F)CCCNC1 360966 (S)-3-(((4-(2- aminobenzo [d]thiazol-4-yl)-2- sulfamoyl-3-(1H- tetrazol-5-yl)phenyl) sulfonamido)methyl)- 3-fluoropiperidin- 1-ium formate::US10221163, Example 122::US10544130, Example 122 Metallo-beta-lactamase type 2 0.282 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360966 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360966&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311517 386400356 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862713 NC(CF)CCNS(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nnn[nH]2)c1S(N)(=O)=O 360967 4-(4-(2-aminobenzo [d]thiazol-4-yl)-2- sulfamoyl-3- (1H-tetrazol-5-yl) phenylsulfonamido)- 1-fluorobutan-2- aminium formate::US10221163, Example 123::US10544130, Example 123 Metallo-beta-lactamase type 2 0.219 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360967 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360967&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135310824 386400357 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862716 NC(CCNS(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nnn[nH]2)c1S(N)(=O)=O)C(F)F 360968 4-(4-(2-aminobenzo [d]thiazol-4-yl)-2- sulfamoyl-3-(1H- tetrazol-5-yl)phenyl- sulfonamido)-1,1- difluorobutan-2- aminium formate::US10221163, Example 124::US10544130, Example 124 Metallo-beta-lactamase type 2 0.222 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360968 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360968&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311503 386400358 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863634 CCOC(=O)c1sc(N)nc1-c1cccc(c1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)NC(CN)CN InChI=1S/C22H26N10O6S3/c1-2-38-21(33)18-17(27-22(25)39-18)12-5-3-4-11(8-12)14-6-7-15(41(36,37)30-13(9-23)10-24)19(40(26,34)35)16(14)20-28-31-32-29-20/h3-8,13,30H,2,9-10,23-24H2,1H3,(H2,25,27)(H2,26,34,35)(H,28,29,31,32) JKAOOUXUHVNVNM-UHFFFAOYSA-N 361274 US10221163, Example 431::US10544130, Example 431 Metallo-beta-lactamase type 2 0.133 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361274 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361274&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 137537604 386400662 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863637 NCc1sc(N)nc1-c1cccc(c1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)N[C@@H]1CCNC1 361275 US10221163, Example 432::US10544130, Example 432 Metallo-beta-lactamase type 2 1.52 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361275 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361275&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 137537605 386400663 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863640 NCCNCc1sc(N)nc1-c1cccc(c1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)N[C@@H]1CCNC1 361276 US10221163, Example 433::US10544130, Example 433 Metallo-beta-lactamase type 2 1.33 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361276 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361276&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 137537735 386400664 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863643 NC[C@H](N)CNS(=O)(=O)c1ccc(-c2cccc(c2)-c2c[nH]c(N)n2)c(-c2nn[nH]n2)c1S(N)(=O)=O 361277 US10221163, Example 434::US10544130, Example 434 Metallo-beta-lactamase type 2 1.53 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361277 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361277&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269287 386400665 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863646 NCC(CN)NS(=O)(=O)c1ccc(-c2cccc(c2)-c2c[nH]c(N)n2)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C19H23N11O4S2/c20-7-12(8-21)28-36(33,34)15-5-4-13(16(17(15)35(23,31)32)18-26-29-30-27-18)10-2-1-3-11(6-10)14-9-24-19(22)25-14/h1-6,9,12,28H,7-8,20-21H2,(H3,22,24,25)(H2,23,31,32)(H,26,27,29,30) ANTMOAIWXABXQH-UHFFFAOYSA-N 361278 US10221163, Example 435::US10544130, Example 435 Metallo-beta-lactamase type 2 1.78 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361278 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361278&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 137537598 386400666 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863649 NCC(CN)NS(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C17H20N10O4S3/c18-6-8(7-19)25-34(30,31)12-5-4-9(10-2-1-3-11-14(10)22-17(20)32-11)13(15(12)33(21,28)29)16-23-26-27-24-16/h1-5,8,25H,6-7,18-19H2,(H2,20,22)(H2,21,28,29)(H,23,24,26,27) HLXWUESRDMZWKV-UHFFFAOYSA-N 361279 US10221163, Example 436::US10544130, Example 436 Metallo-beta-lactamase type 2 0.103 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361279 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361279&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 137537544 386400667 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863652 NCC(CN)NS(=O)(=O)c1ccc(-c2ccnc(c2)-c2cnc(N)[nH]2)c(-c2nnn[nH]2)c1S(N)(=O)=O InChI=1S/C18H22N12O4S2/c19-6-10(7-20)28-36(33,34)14-2-1-11(15(16(14)35(22,31)32)17-26-29-30-27-17)9-3-4-23-12(5-9)13-8-24-18(21)25-13/h1-5,8,10,28H,6-7,19-20H2,(H3,21,24,25)(H2,22,31,32)(H,26,27,29,30) NGXJGSGMLDIREA-UHFFFAOYSA-N 361280 4-(2-(2-Amino-1H-imidazol-5-yl)pyridin-4-yl)-N1-(1,3-diaminopropan-2-yl)-3-(1H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 437::US10544130, Example 437 Metallo-beta-lactamase type 2 2.41 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361280 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361280&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269288 386400668 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863655 NCC(CN)NS(=O)(=O)c1ccc(-c2cccc(n2)-c2cnc(N)[nH]2)c(-c2nnn[nH]2)c1S(N)(=O)=O InChI=1S/C18H22N12O4S2/c19-6-9(7-20)28-36(33,34)14-5-4-10(15(16(14)35(22,31)32)17-26-29-30-27-17)11-2-1-3-12(24-11)13-8-23-18(21)25-13/h1-5,8-9,28H,6-7,19-20H2,(H3,21,23,25)(H2,22,31,32)(H,26,27,29,30) GQESRYREZHSCIP-UHFFFAOYSA-N 361281 4-(6-(2-Amino-1H-imidazol-5-yl)pyridin-2-yl)-N1-(1,3-diaminopropan-2-yl)-3-(1H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 438::US10544130, Example 438 Metallo-beta-lactamase type 2 17.9 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361281 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361281&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269289 386400669 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863658 Nc1ncc([nH]1)-c1cccc(n1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)N[C@@H]1CCNC1 361282 (R)-4-(6-(2-Amino-1H-imidazol-5-yl)pyridin-2-yl)-N1-(pyrrolidin-3-yl)-3-(1H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 439::US10544130, Example 439 Metallo-beta-lactamase type 2 6.72 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361282 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361282&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269290 386400670 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863661 Nc1ncc([nH]1)-c1cc(ccn1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)N[C@@H]1CCNC1 361283 (R)-4-(2-(2-Amino-1H-imidazol-5-yl)pyridin-4-yl)-N1-(pyrrolidin-3-yl)-3-(1H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 440::US10544130, Example 440 Metallo-beta-lactamase type 2 3.96 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361283 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361283&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269291 386400671 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863664 C[C@H](N)Cc1nc2c(cccc2[nH]1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)N[C@@H]1CCNC1 InChI=1S/C21H24N10O4S2/c1-11(22)9-17-25-15-4-2-3-14(19(15)26-17)13-5-6-16(37(34,35)29-12-7-8-24-10-12)20(36(23,32)33)18(13)21-27-30-31-28-21/h2-6,11-12,24,29H,7-10,22H2,1H3,(H2,23,32,33)/b14-13+/t11-,12+/m0/s1 LSRIGDKBJCCBGW-NSILYDBFSA-N 361284 4-(2-((S)-2-Aminopropyl)-1H-benzo[d]imidazol-4-yl)-N1-((R)-pyrrolidin-3-yl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 441::US10544130, Example 441 Metallo-beta-lactamase type 2 1.23 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361284 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361284&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311546 386400672 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863667 C[C@H](N)Cc1nc2c(cccc2[nH]1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(N)(=O)=O InChI=1S/C17H17N9O4S2/c1-8(18)7-13-21-11-4-2-3-10(15(11)22-13)9-5-6-12(31(19,27)28)16(32(20,29)30)14(9)17-23-25-26-24-17/h2-6,8H,7,18H2,1H3,(H2,19,27,28)(H2,20,29,30)/b10-9+/t8-/m0/s1 COKRRBMBKGPUFR-VPOJCXOPSA-N 361285 (S)-4-(2-(2-aminopropyl)- 1H-benzo[d]imidazol-4-yl)- 3-(2H-tetrazol-5-yl)benzene- 1,2-disulfonamide::US10221163, Example 442::US10544130, Example 442 Metallo-beta-lactamase type 2 1.33 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361285 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361285&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135310954 386400673 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863670 NCCNS(=O)(=O)c1ccc(-c2cccc3[nH]c(nc23)C2CNC2)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C19H22N10O4S2/c20-6-7-23-35(32,33)14-5-4-11(15(17(14)34(21,30)31)19-26-28-29-27-19)12-2-1-3-13-16(12)25-18(24-13)10-8-22-9-10/h1-5,10,22-23H,6-9,20H2,(H,24,25)(H2,21,30,31)(H,26,27,28,29) POHULTIMHMVEHW-UHFFFAOYSA-N 361286 N1-(2-aminoethyl)-4-(2- (azetidin-3-yl)-1H- benzo[d]imidazol-4-yl)-3- (2H-tetrazol-5-yl)benzene- 1,2-disulfonamide::US10221163, Example 443::US10544130, Example 443 Metallo-beta-lactamase type 2 0.790 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361286 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361286&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135310886 386400674 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863673 NCCNS(=O)(=O)c1ccc(-c2cccc3[nH]c(nc23)[C@@H]2C[C@@H](O)CN2)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C20H22N10O5S2/c21-6-7-24-37(34,35)15-5-4-11(16(18(15)36(22,32)33)20-27-29-30-28-20)12-2-1-3-13-17(12)26-19(25-13)14-8-10(31)9-23-14/h1-5,10,14,23-24,31H,6-9,21H2,(H2,22,32,33)/b12-11+/t10-,14+/m1/s1 FURQKPFVDFTLFW-SQXJLYEZSA-N 361287 N1-(2-aminoethyl)-4-(2- ((2S,4R)-4- hydroxypyrrolidin-2-yl)-1H- benzo[d]imidazol-4-yl)-3- (2H-tetrazol-5-yl)benzene- 1,2-disulfonamide::US10221163, Example 444::US10544130, Example 444 Metallo-beta-lactamase type 2 1.59 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361287 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361287&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311012 386400675 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863676 NCCNS(=O)(=O)c1ccc(-c2cccc3[nH]c(nc23)C(F)(F)CN)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C18H20F2N10O4S2/c19-18(20,8-22)17-25-11-3-1-2-10(14(11)26-17)9-4-5-12(36(33,34)24-7-6-21)15(35(23,31)32)13(9)16-27-29-30-28-16/h1-5,24H,6-8,21-22H2,(H,25,26)(H2,23,31,32)(H,27,28,29,30) BSSOREZAYOZEAB-UHFFFAOYSA-N 361288 4-(2-(2-amino-1,1- difluoroethyl)-1H- benzo[d]imidazol-4-yl)-N1- (2-aminoethyl)-3-(2H- tetrazol-5-yl)benzene-1,2- disulfonamide::US10221163, Example 445::US10544130, Example 445 Metallo-beta-lactamase type 2 0.370 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361288 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361288&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135310710 386400676 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863679 NCC(F)(F)c1nc2c(cccc2[nH]1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)N[C@H]1CCNC1 InChI=1S/C20H20F2N10O4S2/c21-20(22,9-23)19-26-13-3-1-2-12(16(13)27-19)11-4-5-14(38(35,36)30-10-6-7-25-8-10)17(37(24,33)34)15(11)18-28-31-32-29-18/h1-5,10,25,30H,6-9,23H2,(H2,24,33,34)/b12-11+/t10-/m0/s1 LRUAIGJOZPWOOH-IUZMTQGWSA-N 361289 (S)-4-(2-(2-amino-1,1- difluoroethyl)-1H- benzo[d]imidazol-4-yl)-N1- (pyrrolidin-3-yl)-3-(2H- tetrazol-5-yl)benzene-1,2- disulfonamide::US10221163, Example 446::US10544130, Example 446 Metallo-beta-lactamase type 2 0.446 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361289 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361289&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135310917 386400677 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863682 NCCNC(=O)c1cc(Cl)cc(c1N)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)NCCN InChI=1S/C18H23ClN10O5S2/c19-9-7-11(15(22)12(8-9)18(30)24-5-3-20)10-1-2-13(36(33,34)25-6-4-21)16(35(23,31)32)14(10)17-26-28-29-27-17/h1-2,7-8,25H,3-6,20-22H2,(H,24,30)(H2,23,31,32)(H,26,27,28,29) BOWSJWYIIKQERX-UHFFFAOYSA-N 361290 2-Amino-N-(2-aminoethyl)-4′-(N-(2-aminoethyl)sulfamoyl)-5-chloro-3′-sulfamoyl-2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-3-carboxamide::US10221163, Example 447::US10544130, Example 447 Metallo-beta-lactamase type 2 1.60 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361290 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361290&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124158313 386400678 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863685 N[C@@H]1C[C@H]1NS(=O)(=O)c1ccc(-c2cccc3[nH]c(N)nc23)c(-c2nnn[nH]2)c1S(N)(=O)=O InChI=1S/C17H16N10O4S2/c18-9-6-11(9)25-33(30,31)12-5-4-7(8-2-1-3-10-14(8)22-17(19)21-10)13(15(12)32(20,28)29)16-23-26-27-24-16/h1-5,9,11,25H,6,18H2,(H2,19,21)(H2,20,28,29)/b8-7+/t9-,11-/m1/s1 KAEOIIUECHQSQD-FQZVFUSHSA-N 361291 4-(2-amino-1H-benzo[d]imidazol-4-yl)-N1-((1R,2R)-2-aminocyclopropyl)-3-(1H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 448::US10544130, Example 448 Metallo-beta-lactamase type 2 0.988 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361291 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361291&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311433 386400679 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863688 CN(CCN)S(=O)(=O)c1ccc(-c2cccc3[nH]c(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C17H20N10O4S2/c1-27(8-7-18)33(30,31)12-6-5-9(10-3-2-4-11-14(10)22-17(19)21-11)13(15(12)32(20,28)29)16-23-25-26-24-16/h2-6H,7-8,18H2,1H3,(H3,19,21,22)(H2,20,28,29)(H,23,24,25,26) PGWUOFRMVJEOIN-UHFFFAOYSA-N 427613 4-(2-amino-1H-benzo[d]imidazol-4-yl)-N1-(2-aminoethyl)-N1-methyl-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10544130, Example 449 Metallo-beta-lactamase type 2 11.8 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=427613 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=427613&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311480 434317380 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863691 NCCNC(=O)c1cc(Cl)cc(c1N)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)N[C@@H]1CCNC1 427614 (R)-2-Amino-N-(2-aminoethyl)-5-chloro-4′-(N-(pyrrolidin-3-yl)sulfamoyl)-3′-sulfamoyl-2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-3-carboxamide::US10544130, Example 450 Metallo-beta-lactamase type 2 3.42 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=427614 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=427614&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 154732678 434317381 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863694 NCCNC(=O)c1cc(ccc1N)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)NCCN InChI=1S/C18H24N10O5S2/c19-5-7-23-18(29)12-9-10(1-3-13(12)21)11-2-4-14(35(32,33)24-8-6-20)16(34(22,30)31)15(11)17-25-27-28-26-17/h1-4,9,24H,5-8,19-21H2,(H,23,29)(H2,22,30,31)(H,25,26,27,28) MHMCEJWETAYNFG-UHFFFAOYSA-N 361294 4-Amino-N-(2-aminoethyl)-4′-(N-(2-aminoethyl)sulfamoyl)-3′-sulfamoyl-2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-3-carboxamide::US10221163, Example 451::US10544130, Example 451 Metallo-beta-lactamase type 2 4.02 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361294 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361294&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135310881 386400682 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862719 Nc1nc2c(cccc2s1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)NC[C@@H]1CCCN1 360969 (S)-2-((4-(2- aminobenzo [d]thiazol-4-yl)-2- sulfamoyl-3-(1H- tetrazol-5-yl)phenyl- sulfonamido)methyl) pyrrolidin-1- ium formate::US10221163, Example 125::US10544130, Example 125 Metallo-beta-lactamase type 2 0.286 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360969 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360969&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311859 386400359 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862722 Nc1nc2c(cccc2s1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)NC[C@H]1CCCN1 360970 (R)-2-((4-(2- aminobenzo [d]thiazol-4-yl)-2- sulfamoyl-3- (1H-tetrazol-5-yl) phenylsulfonamido) methyl)pyrrolidin-1- ium formate::US10221163, Example 126::US10544130, Example 126 Metallo-beta-lactamase type 2 0.222 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360970 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360970&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311310 386400360 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862725 C[C@H](N)CNS(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nnn[nH]2)c1S(N)(=O)=O 360971 (S)-4-(2-aminobenzo [d]thiazol-4-yl)-N1- (2-aminopropyl)- 3-(1H-tetrazol-5- yl)benzene-1,2- disulfonamide, formate salt::US10221163, Example 127::US10544130, Example 127 Metallo-beta-lactamase type 2 0.322 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360971 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360971&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311402 386400361 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862728 COC(=O)[C@H]1C[C@H](CN1)NS(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nnn[nH]2)c1S(N)(=O)=O 360972 Methyl (2R,4R)-4-((4-(2-aminobenzo[d]thiazol-4-yl)-2-sulfamoyl-3-(1H-tetrazol-5-yl)phenyl)sulfonamido)pyrrolidine-2-carboxylate::US10221163, Example 128::US10544130, Example 128 Metallo-beta-lactamase type 2 0.177 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360972 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360972&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124159693 386400362 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862731 CN(C)C(=O)c1ccccc1-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)N[C@@H]1CCNC1 360973 (R)-N,N-dimethyl-4'-(N- (pyrrolidin-3-yl)sulfamoyl)-3'- sulfamoyl-2'-(1H-tetrazol-5-yl)- [1,1'-biphenyl]-2-carboxamide::US10221163, Example 129::US10544130, Example 129 Metallo-beta-lactamase type 2 9.07 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360973 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360973&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311594 386400363 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862734 NS(=O)(=O)c1c(ccc(-c2cccc3nc(O)[nH]c23)c1-c1nnn[nH]1)S(=O)(=O)N[C@@H]1CCNC1 InChI=1S/C18H17N9O5S2/c19-33(29,30)16-13(34(31,32)25-9-6-7-20-8-9)5-4-10(14(16)17-23-26-27-24-17)11-2-1-3-12-15(11)22-18(28)21-12/h1-5,9,20,25H,6-8H2,(H,21,28)(H2,19,29,30)/b11-10+/t9-/m1/s1 WOINWUWKNUOGCI-HNLKAFMCSA-N 360974 (R)-4-(2-hydroxy-1H- benzo[d]imidazol-7-yl)-N1- (pyrrolidin-3-yl)-3-(1H-tetrazol- 5-yl)benzene-1,2-disulfonamide::US10221163, Example 130::US10544130, Example 130 Metallo-beta-lactamase type 2 0.684 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360974 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360974&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269202 386400364 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862737 NS(=O)(=O)c1c(ccc(-c2cccc3OC(F)(F)Oc23)c1-c1nnn[nH]1)S(=O)(=O)N[C@@H]1CCNC1 360975 (R)-4-(2,2- difluorobenzo[d][1,3]dioxol-4- yl)-N1-(pyrrolidin-3-yl)-3-(1H- tetrazol-5-yl)benzene-1,2- disulfonamide::US10221163, Example 131::US10544130, Example 131 Metallo-beta-lactamase type 2 1.83 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360975 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360975&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269203 386400365 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862740 Nc1c(cccc1-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)N[C@@H]1CCNC1)C#N 360976 (R)-2'-amino-3'-cyano-N4- (pyrrolidin-3-yl)-2-(1H-tetrazol- 5-yl)-[1,1'-biphenyl]-3,4- disulfonamide::US10221163, Example 132::US10544130, Example 132 Metallo-beta-lactamase type 2 1.40 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360976 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360976&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135310829 386400366 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862743 NS(=O)(=O)c1c(ccc(-c2ccc3nonc3c2)c1-c1nnn[nH]1)S(=O)(=O)N[C@@H]1CCNC1 360977 (R)-4-(benzo[c][1,2,5]oxadiazol- 5-yl)-N1-(pyrrolidin-3-yl)-3- (1H-tetrazol-5-yl)benzene-1,2- disulfonamide::US10221163, Example 133::US10544130, Example 133 Metallo-beta-lactamase type 2 0.816 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360977 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360977&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135310703 386400367 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862746 Cn1nnc2ccc(cc12)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)N[C@@H]1CCNC1 360978 (R)-4-(1-methyl-1H- benzo[d][1,2,3]triazol-6-yl)-N1- (pyrrolidin-3-yl)-3-(1H-tetrazol- 5-yl)benzene-1,2-disulfonamide::US10221163, Example 134::US10544130, Example 134 Metallo-beta-lactamase type 2 2.07 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360978 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360978&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135310950 386400368 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862749 NS(=O)(=O)c1ccc(cc1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)N[C@@H]1CCNC1 360979 (R)-N4-(pyrrolidin-3-yl)-2-(1H- tetrazol-5-yl)-[1,1'-biphenyl]- 3,4,4'-trisulfonamide::US10221163, Example 135::US10544130, Example 135 Metallo-beta-lactamase type 2 0.229 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360979 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360979&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311131 386400369 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862752 CS(=O)(=O)Nc1ccc(cc1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)N[C@@H]1CCNC1 360980 (R)-4'-(methylsulfonamido)-N4- (pyrrolidin-3-yl)-2-(1H-tetrazol- 5-yl)-[1,1'-biphenyl]-3,4- disulfonamide::US10221163, Example 136::US10544130, Example 136 Metallo-beta-lactamase type 2 0.075 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360980 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360980&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311601 386400370 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862755 NC(=O)c1ccc(cc1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)N[C@@H]1CCNC1 360981 (R)-4'-(N-(pyrrolidin-3- yl)sulfamoyl)-3'-sulfamoyl-2'- (1H-tetrazol-5-yl)-[1,1'- biphenyl]-4-carboxamide::US10221163, Example 137::US10544130, Example 137 Metallo-beta-lactamase type 2 0.265 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360981 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360981&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311648 386400371 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862758 NS(=O)(=O)c1c(ccc(-c2ccc3CNC(=O)c3c2)c1-c1nnn[nH]1)S(=O)(=O)N[C@@H]1CCNC1 360982 (R)-4-(3-oxoisoindolin-5-yl)-N1- (pyrrolidin-3-yl)-3-(1H-tetrazol- 5-yl)benzene-1,2-disulfonamide::US10221163, Example 138::US10544130, Example 138 Metallo-beta-lactamase type 2 0.275 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360982 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360982&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311413 386400372 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862761 NS(=O)(=O)c1c(ccc(-c2cccc3cn[nH]c23)c1-c1nnn[nH]1)S(=O)(=O)N[C@@H]1CCNC1 InChI=1S/C18H17N9O4S2/c19-32(28,29)17-14(33(30,31)25-11-6-7-20-9-11)5-4-12(15(17)18-23-26-27-24-18)13-3-1-2-10-8-21-22-16(10)13/h1-5,8,11,20,25H,6-7,9H2,(H2,19,28,29)/b13-12+/t11-/m1/s1 GYELOXHNEKJFSR-GXZRWPEMSA-N 360983 (R)-4-(1H-indazol-7-yl)-N1- (pyrrolidin-3-yl)-3-(1H-tetrazol- 5-yl)benzene-1,2-disulfonamide::US10221163, Example 139::US10544130, Example 139 Metallo-beta-lactamase type 2 0.410 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360983 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360983&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311574 386400373 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862764 NS(=O)(=O)c1c(ccc(-c2cnc3ccccn23)c1-c1nnn[nH]1)S(=O)(=O)N[C@@H]1CCNC1 360984 (R)-4-(imidazo[1,2-a]pyridin-3- yl)-N1-(pyrrolidin-3-yl)-3-(1H- tetrazol-5-yl)benzene-1,2- disulfonamide::US10221163, Example 140::US10544130, Example 140 Metallo-beta-lactamase type 2 0.779 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360984 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360984&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311521 386400374 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862767 C[C@H]1NC(=O)O[C@H]1c1ccc(cc1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)N[C@@H]1CCNC1 360985 4'-((4R,5S)-4-methyl-2- oxooxazolidin-5-yl)-N4-((R)- pyrrolidin-3-yl)-2-(1H-tetrazol- 5-yl)-[1,1'-biphenyl]-3,4- disulfonamide::US10221163, Example 141::US10544130, Example 141 Metallo-beta-lactamase type 2 0.041 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360985 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360985&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269204 386400375 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862770 Nc1nc2c(cccc2s1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)N1CCNCC1 InChI=1S/C18H19N9O4S3/c19-18-22-15-11(2-1-3-12(15)32-18)10-4-5-13(34(30,31)27-8-6-21-7-9-27)16(33(20,28)29)14(10)17-23-25-26-24-17/h1-5,21H,6-9H2,(H2,19,22)(H2,20,28,29)(H,23,24,25,26) YFQVRYQHRYRIBR-UHFFFAOYSA-N 360986 3-(2-Aminobenzo[d]thiazol-4-yl)-6-(piperazin-1-ylsulfonyl)-2-(2H-tetrazol-5-yl)benzenesulfonamide::US10221163, Example 142::US10544130, Example 142 Metallo-beta-lactamase type 2 0.636 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360986 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360986&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269205 386400376 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862773 Nc1nc2c(cccc2s1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(N)(=O)=O InChI=1S/C14H12N8O4S3/c15-14-18-11-7(2-1-3-8(11)27-14)6-4-5-9(28(16,23)24)12(29(17,25)26)10(6)13-19-21-22-20-13/h1-5H,(H2,15,18)(H2,16,23,24)(H2,17,25,26)(H,19,20,21,22) DFEIOWJQIXAABN-UHFFFAOYSA-N 360987 4-(2-aminobenzo[d]thiazol-4- yl)-3-(2H-tetrazol-5- yl)benzene-1,2-disulfonamide::US10221163, Example 143::US10544130, Example 143 Metallo-beta-lactamase type 2 0.266 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360987 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360987&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269206 386400377 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862776 Nc1nc2c(cccc2s1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)NCCO InChI=1S/C16H16N8O5S3/c17-16-20-13-9(2-1-3-10(13)30-16)8-4-5-11(32(28,29)19-6-7-25)14(31(18,26)27)12(8)15-21-23-24-22-15/h1-5,19,25H,6-7H2,(H2,17,20)(H2,18,26,27)(H,21,22,23,24) FZQGKUYDMKKPSR-UHFFFAOYSA-N 360988 4-(2-aminobenzo[d]thiazol-4- yl)-N1-(2-hydroxyethyl)-3- (2H-tetrazol-5-yl)benzene-1,2- disulfonamide::US10221163, Example 144::US10544130, Example 144 Metallo-beta-lactamase type 2 0.288 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360988 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360988&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269207 386400378 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 862779 NCCNS(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C16H17N9O4S3/c17-6-7-20-32(28,29)11-5-4-8(9-2-1-3-10-13(9)21-16(18)30-10)12(14(11)31(19,26)27)15-22-24-25-23-15/h1-5,20H,6-7,17H2,(H2,18,21)(H2,19,26,27)(H,22,23,24,25) DGBXDGANRYBJPM-UHFFFAOYSA-N 360989 4-(2-aminobenzo[d]thiazol-4- yl)-N1-(2-aminoethyl)-3-(2H- tetrazol-5-yl)benzene-1,2- disulfonamide::US10221163, Example 145::US10544130, Example 145 Metallo-beta-lactamase type 2 0.221 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360989 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360989&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269208 386400379 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863697 NCCNS(=O)(=O)c1ccc(-c2ccccc2NC(=O)CN)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C17H21N9O5S2/c18-7-8-21-33(30,31)13-6-5-11(10-3-1-2-4-12(10)22-14(27)9-19)15(16(13)32(20,28)29)17-23-25-26-24-17/h1-6,21H,7-9,18-19H2,(H,22,27)(H2,20,28,29)(H,23,24,25,26) AUDKQARKDIVADP-UHFFFAOYSA-N 361295 2-Amino-N-(4′-(N-(2-aminoethyl)sulfamoyl)-3′-sulfamoyl-2′-(2H-tetrazol-5-yl-[1,1′-biphenyl]-2-yl)acetamide::US10221163, Example 452::US10544130, Example 452 Metallo-beta-lactamase type 2 6.21 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361295 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361295&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 137537562 386400683 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863700 NCCNS(=O)(=O)c1ccc(-c2cccc(NC(=O)[C@@H](N)CN)c2)c(-c2nn[nH]n2)c1S(N)(=O)=O 361296 (S)-2,3-Diamino-N-(4′-(N-(2-aminoethyl)sulfamoyl)-3′-sulfamoyl-2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-3-yl)propanamide::US10221163, Example 453::US10544130, Example 453 Metallo-beta-lactamase type 2 3.52 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361296 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361296&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124158225 386400684 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863703 NCCNS(=O)(=O)c1ccc(-c2cccc(NC(=O)[C@H](N)CO)c2)c(-c2nn[nH]n2)c1S(N)(=O)=O 361297 (R)-2-amino-N-(4'-(N-(2- aminoethyl)sulfamoyl)-3'- sulfamoyl-2'-(2H-tetrazol-5- yl)-[1,1'-biphenyl]-3-yl)-3- hydroxypropanamide::US10221163, Example 454::US10544130, Example 454 Metallo-beta-lactamase type 2 3.46 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361297 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361297&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311893 386400685 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863706 NCCNS(=O)(=O)c1ccc(-c2cccc3NCCCc23)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C18H22N8O4S2/c19-8-10-22-32(29,30)15-7-6-13(11-3-1-5-14-12(11)4-2-9-21-14)16(17(15)31(20,27)28)18-23-25-26-24-18/h1,3,5-7,21-22H,2,4,8-10,19H2,(H2,20,27,28)(H,23,24,25,26) GQMKFJFLZZHKEE-UHFFFAOYSA-N 361298 N1-(2-Aminoethyl)-4-(1,2,3,4-tetrahydroquinolin-5-yl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 455::US10544130, Example 455 Metallo-beta-lactamase type 2 0.530 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361298 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361298&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311072 386400686 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863709 NCCNc1cc(ccn1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)NCCN InChI=1S/C16H22N10O4S2/c17-4-7-21-13-9-10(3-6-20-13)11-1-2-12(32(29,30)22-8-5-18)15(31(19,27)28)14(11)16-23-25-26-24-16/h1-3,6,9,22H,4-5,7-8,17-18H2,(H,20,21)(H2,19,27,28)(H,23,24,25,26) OZTGBIOQFYIWIA-UHFFFAOYSA-N 361299 N1-(2-Aminoethyl)-4-(2-((2-aminoethyl)amino)pyridin-4-yl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 456::US10544130, Example 456 Metallo-beta-lactamase type 2 3.77 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361299 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361299&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135310935 386400687 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863712 NCCNc1cc(ccn1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)NCCO InChI=1S/C16H21N9O5S2/c17-4-6-20-13-9-10(3-5-19-13)11-1-2-12(32(29,30)21-7-8-26)15(31(18,27)28)14(11)16-22-24-25-23-16/h1-3,5,9,21,26H,4,6-8,17H2,(H,19,20)(H2,18,27,28)(H,22,23,24,25) ARBCOGFEJXLOLI-UHFFFAOYSA-N 361300 4-(2-((2- aminoethyl)amino)pyridin-4- yl)-N1-(2-hydroxyethyl)-3- (2H-tetrazol-5-yl)benzene- 1,2-disulfonamide::US10221163, Example 457::US10544130, Example 457 Metallo-beta-lactamase type 2 5.29 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361300 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361300&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311300 386400688 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863715 NCCNc1cc(ccn1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)N[C@@H]1CCNC1 361301 (R)-4-(2-((2- aminoethyl)amino)pyridin-4- yl)-N1-(pyrrolidin-3-yl)-3- (2H-tetrazol-5-yl)benzene- 1,2-disulfonamide::US10221163, Example 458::US10544130, Example 458 Metallo-beta-lactamase type 2 3.77 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361301 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361301&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311249 386400689 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863718 NCCNc1ncccc1-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)N[C@@H]1CCNC1 361302 (R)-4-(2-((2- Aminoethyl)amino)pyridin- 3-yl)-N1-(pyrrolidin-3-yl)-3- (2H-tetrazol-5-yl)benzene- 1,2-disulfonamide::US10221163, Example 459::US10544130, Example 459 Metallo-beta-lactamase type 2 12.5 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361302 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361302&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311524 386400690 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863721 C[C@H](CN)NS(=O)(=O)c1ccc(-c2cccnc2NCCN)c(-c2nn[nH]n2)c1S(N)(=O)=O 361303 (R)-4-(2-((2- aminoethyl)amino)pyridin-3 yl)-N1-(1-aminopropan-2- yl)-3-(2H-tetrazol-5- yl)benzene-1,2- disulfonamide::US10221163, Example 460::US10544130, Example 460 Metallo-beta-lactamase type 2 4.63 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361303 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361303&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311186 386400691 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863724 NCCNS(=O)(=O)c1ccc(-c2ccnc(CN)c2)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C15H19N9O4S2/c16-4-6-20-30(27,28)12-2-1-11(9-3-5-19-10(7-9)8-17)13(14(12)29(18,25)26)15-21-23-24-22-15/h1-3,5,7,20H,4,6,8,16-17H2,(H2,18,25,26)(H,21,22,23,24) RFCNFEVBCWVNCO-UHFFFAOYSA-N 361304 N1-(2-Aminoethyl)-4-(2-(aminomethyl)pyridin-4-yl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 461::US10544130, Example 461 Metallo-beta-lactamase type 2 50.4 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361304 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361304&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 139269292 386400692 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863727 NCc1nc(c[nH]1)-c1cccc(c1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)N[C@H]1CNC[C@H]1N 361305 (R)-3′-(2-(aminomethyl)-1H-imidazol-4-yl)-N4-(2-aminopropyl)-2-(2H -tetrazol-5-yl-[1,1′-biphenyl]-3,4-disulfonamide::US10221163, Example 462::US10544130, Example 462 Metallo-beta-lactamase type 2 1.29 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361305 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361305&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135310696 386400693 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863730 NC[C@@H](O)CNS(=O)(=O)c1ccc(-c2ccc3sc(CN)nc3c2)c(-c2nn[nH]n2)c1S(N)(=O)=O 361306 (R)—N1-(3-amino-2-hydroxypropyl)-4-(2-(aminomethyl)benzo[d]thiazol-5-yl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 463::US10544130, Example 463 Metallo-beta-lactamase type 2 0.325 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361306 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361306&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311067 386400694 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863733 NC[C@@H](O)CNS(=O)(=O)c1ccc(-c2ccc3[nH]c(CN)nc3c2)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C18H20N10O5S2/c19-6-10(29)8-22-35(32,33)14-4-2-11(9-1-3-12-13(5-9)24-15(7-20)23-12)16(17(14)34(21,30)31)18-25-27-28-26-18/h1-5,10,22,29H,6-8,19-20H2,(H2,21,30,31)/b11-9+/t10-/m1/s1 WZIIXEJTRGFYTP-OYVNLZQHSA-N 361307 (R)—N1-(3-amino-2-hydroxypropyl)-4-(2-(aminomethyl)-1H-benzo[d]imidazole-5-yl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 464::US10544130, Example 464 Metallo-beta-lactamase type 2 1.84 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361307 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361307&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311210 386400695 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863736 NC[C@H](O)CNS(=O)(=O)c1ccc(-c2ccc3[nH]c(CN)nc3c2)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C18H20N10O5S2/c19-6-10(29)8-22-35(32,33)14-4-2-11(9-1-3-12-13(5-9)24-15(7-20)23-12)16(17(14)34(21,30)31)18-25-27-28-26-18/h1-5,10,22,29H,6-8,19-20H2,(H2,21,30,31)/b11-9+/t10-/m0/s1 WZIIXEJTRGFYTP-SPQRFVMMSA-N 361308 S)-N1-(3-amino-2- hydroxypropyl)-4-(2- (aminomethyl)-1H-benzo[d] imidazol-5-yl)-3-(2H- tetrazol-5-yl)benzene-1,2- disulfonamide::US10221163, Example 465::US10544130, Example 465 Metallo-beta-lactamase type 2 1.15 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361308 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361308&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 137537681 386400696 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863739 NCCNS(=O)(=O)c1ccc(-c2ccc3[nH]c(CN)nc3c2)c(-c2nn[nH]n2)c1S(N)(=O)=O InChI=1S/C17H20N10O4S2/c18-5-6-21-33(30,31)13-4-2-10(9-1-3-11-12(7-9)23-14(8-19)22-11)15(16(13)32(20,28)29)17-24-26-27-25-17/h1-4,7,21H,5-6,8,18-19H2,(H,22,23)(H2,20,28,29)(H,24,25,26,27) FLIUGCCDOLARIN-UHFFFAOYSA-N 361309 N1-(2-aminoethyl)-4-(2-(aminomethyl)-1H-benzo[d]imidazol-5-yl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 466::US10544130, Example 466 Metallo-beta-lactamase type 2 0.967 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361309 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361309&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311039 386400697 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863742 CNc1nc2c(cccc2[nH]1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)NCCN InChI=1S/C17H20N10O4S2/c1-20-17-22-11-4-2-3-10(14(11)23-17)9-5-6-12(33(30,31)21-8-7-18)15(32(19,28)29)13(9)16-24-26-27-25-16/h2-6,21H,7-8,18H2,1H3,(H2,19,28,29)(H2,20,22,23)(H,24,25,26,27) IAQFFDQRSKBBQD-UHFFFAOYSA-N 361310 N1-(2-aminoethyl)-4-(2- (methylamino)-1H- benzo[d]imidazol-4-yl)-3- (2H-tetrazol-5-yl)benzene-1,2- disulfonamide::US10221163, Example 467::US10544130, Example 467 Metallo-beta-lactamase type 2 0.437 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361310 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361310&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311436 386400698 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863745 Cc1cc(cnc1N)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)NC[C@@H](O)CN 361311 (S)-N1-(3-amino-2- hydroxypropyl)-4-(6-amino-5- methylpyridin-3-yl)-3-(2H- tetrazol-5-yl)benzene-1,2- disulfonamide::US10221163, Example 468::US10544130, Example 468 Metallo-beta-lactamase type 2 0.569 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361311 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361311&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311025 386400699 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863748 NC[C@H](O)CNS(=O)(=O)c1ccc(-c2cnc(N)c(F)c2)c(-c2nn[nH]n2)c1S(N)(=O)=O 361312 (S)-N1-(3-amino-2- hydroxypropyl)-4-(6-amino-5- fluoropyridin-3-yl)-3-(2H- tetrazol-5-yl)benzene-1,2- disulfonamide::US10221163, Example 469::US10544130, Example 469 Metallo-beta-lactamase type 2 0.554 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361312 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361312&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311277 386400700 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863751 NS(=O)(=O)c1c(ccc(-c2cccc(Nc3nc(CO)cs3)c2)c1-c1nn[nH]n1)S(=O)(=O)N[C@@H]1CCNC1 361313 (R)-3'-((4- (hydroxymethyl)thiazol-2- yl)amino)-N4-(pyrrolidin-3-yl)- 2-(2H-tetrazol-5-yl)-[1,1'- biphenyl]-3,4-disulfonamide::US10221163, Example 470::US10544130, Example 470 Metallo-beta-lactamase type 2 0.134 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361313 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361313&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 135311508 386400701 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 863754 NC(=O)c1csc(Nc2cccc(c2)-c2ccc(c(c2-c2nn[nH]n2)S(N)(=O)=O)S(=O)(=O)N[C@@H]2CCNC2)n1 361314 (R)-2-((4′-(N-(pyrrolidin-3-yl)sulfamoyl)-3′-sulfamoyl-2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-3-yl)amino)thiazole-4-carboxamide::BDBM427635::US10221163, Example 471 Metallo-beta-lactamase type 2 0.111 US Patent 10.7270/Q2C82CQH aid1804113 US10544130 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361314 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361314&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 124158369 386400702 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA Metallo-beta-lactamase type 2 BLAB_SERMA P52699 51510346 [Na+].[Na+].OC(CC([O-])=O)(CC(=O)OCc1ccccc1)C([O-])=O InChI=1S/C13H14O7.2Na/c14-10(15)6-13(19,12(17)18)7-11(16)20-8-9-4-2-1-3-5-9;;/h1-5,19H,6-8H2,(H,14,15)(H,17,18);;/q;2*+1/p-2 POPQCIKYWIPBLS-UHFFFAOYSA-L 50608034 CHEMBL5290157 Metallo-beta-lactamase type 2 >5000000 ChEMBL 10.7270/Q2WW7NWT 34242022 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50608034 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=416&target=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50608034&enzyme=Metallo-beta-lactamase+type+2&column=ki&startPg=0&Increment=50&submit=Search 160265143 494497782 1 MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN 1DD6,1DDK,1JJE,1JJT,1VGN,2DOO,3WXC,4C1F,4C1G,4UAM,5EV6,5EV8,5EWA,5Y5B,6JED,6LBL,6ZYR,6ZYS,7DTM,7XHW,7YH9,7YHA,8HYB,8JAO Metallo-beta-lactamase type 2 BLAB_SERMA P52699