BindingDB Reactant_set_id Ligand SMILES Ligand InChI Ligand InChI Key BindingDB MonomerID BindingDB Ligand Name Target Name Target Source Organism According to Curator or DataSource Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) kon (M-1-s-1) koff (s-1) pH Temp (C) Curation/DataSource Article DOI BindingDB Entry DOI PMID PubChem AID Patent Number Authors Institution Link to Ligand in BindingDB Link to Target in BindingDB Link to Ligand-Target Pair in BindingDB Ligand HET ID in PDB PDB ID(s) for Ligand-Target Complex PubChem CID of Ligand PubChem SID of Ligand ChEBI ID of Ligand ChEMBL ID of Ligand DrugBank ID of Ligand IUPHAR_GRAC ID of Ligand KEGG ID of Ligand ZINC ID of Ligand Number of Protein Chains in Target (>1 implies a multichain complex) BindingDB Target Chain Sequence PDB ID(s) of Target Chain UniProt (SwissProt) Recommended Name of Target Chain UniProt (SwissProt) Entry Name of Target Chain UniProt (SwissProt) Primary ID of Target Chain UniProt (SwissProt) Secondary ID(s) of Target Chain UniProt (SwissProt) Alternative ID(s) of Target Chain UniProt (TrEMBL) Submitted Name of Target Chain UniProt (TrEMBL) Entry Name of Target Chain UniProt (TrEMBL) Primary ID of Target Chain UniProt (TrEMBL) Secondary ID(s) of Target Chain UniProt (TrEMBL) Alternative ID(s) of Target Chain 58317 Clc1cccc(NC(=O)c2ccc(Br)o2)c1N1CCNCC1 InChI=1S/C15H15BrClN3O2/c16-13-5-4-12(22-13)15(21)19-11-3-1-2-10(17)14(11)20-8-6-18-7-9-20/h1-5,18H,6-9H2,(H,19,21) MRQHYUPABCEKKS-UHFFFAOYSA-N 32453 piperazine amide, 4a Isoform Alpha-1 of Mitogen-activated protein kinase 10 (Alpha-1) 9-402] Homo sapiens 9900 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2009.03.086 10.7270/Q2ST7N67 19433357 aid1799204 Shin, Y; Chen, W; Habel, J; Duckett, D; Ling, YY; Koenig, M; He, Y; Vojkovsky, T; LoGrasso, P; Kamenecka, TM The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=32453 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4017&target=Isoform+Alpha-1+of+Mitogen-activated+protein+kinase+10+%28Alpha-1%29+9-402%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=32453&enzyme=Isoform+Alpha-1+of+Mitogen-activated+protein+kinase+10+%28Alpha-1%29+9-402%5D&column=ki&startPg=0&Increment=50&submit=Search 44236943 85256320 ZINC62241832 1 MSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSE 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4L7F,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4X21,4Y46,4Y5H,4YR8,4Z9L,6EKD,6EMH,6EQ9,6ZR5,7KSI,7KSJ,7KSK,7ORE,7ORF,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 58318 CN1CCN(CC1)c1c(Cl)cccc1NC(=O)c1ccc(Br)o1 InChI=1S/C16H17BrClN3O2/c1-20-7-9-21(10-8-20)15-11(18)3-2-4-12(15)19-16(22)13-5-6-14(17)23-13/h2-6H,7-10H2,1H3,(H,19,22) QTLUVUGKTKECIF-UHFFFAOYSA-N 32454 piperazine amide, 4b Isoform Alpha-1 of Mitogen-activated protein kinase 10 (Alpha-1) 9-402] Homo sapiens 1200 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2009.03.086 10.7270/Q2ST7N67 19433357 aid1799204 Shin, Y; Chen, W; Habel, J; Duckett, D; Ling, YY; Koenig, M; He, Y; Vojkovsky, T; LoGrasso, P; Kamenecka, TM The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=32454 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4017&target=Isoform+Alpha-1+of+Mitogen-activated+protein+kinase+10+%28Alpha-1%29+9-402%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=32454&enzyme=Isoform+Alpha-1+of+Mitogen-activated+protein+kinase+10+%28Alpha-1%29+9-402%5D&column=ki&startPg=0&Increment=50&submit=Search 42537838 85256321 ZINC12325075 1 MSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSE 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4L7F,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4X21,4Y46,4Y5H,4YR8,4Z9L,6EKD,6EMH,6EQ9,6ZR5,7KSI,7KSJ,7KSK,7ORE,7ORF,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 58319 CCN1CCN(CC1)c1c(Cl)cccc1NC(=O)c1ccc(Br)o1 InChI=1S/C17H19BrClN3O2/c1-2-21-8-10-22(11-9-21)16-12(19)4-3-5-13(16)20-17(23)14-6-7-15(18)24-14/h3-7H,2,8-11H2,1H3,(H,20,23) PRHPUPZVWXCHHI-UHFFFAOYSA-N 32455 cid_979869::piperazine amide, 1 Isoform Alpha-1 of Mitogen-activated protein kinase 10 (Alpha-1) 9-402] Homo sapiens 1100 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2009.03.086 10.7270/Q2ST7N67 19433357 aid1799204 Shin, Y; Chen, W; Habel, J; Duckett, D; Ling, YY; Koenig, M; He, Y; Vojkovsky, T; LoGrasso, P; Kamenecka, TM The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=32455 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4017&target=Isoform+Alpha-1+of+Mitogen-activated+protein+kinase+10+%28Alpha-1%29+9-402%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=32455&enzyme=Isoform+Alpha-1+of+Mitogen-activated+protein+kinase+10+%28Alpha-1%29+9-402%5D&column=ki&startPg=0&Increment=50&submit=Search 979869 85256322 ZINC00624282 1 MSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSE 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4L7F,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4X21,4Y46,4Y5H,4YR8,4Z9L,6EKD,6EMH,6EQ9,6ZR5,7KSI,7KSJ,7KSK,7ORE,7ORF,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 58320 CCCN1CCN(CC1)c1c(Cl)cccc1NC(=O)c1ccc(Br)o1 InChI=1S/C18H21BrClN3O2/c1-2-8-22-9-11-23(12-10-22)17-13(20)4-3-5-14(17)21-18(24)15-6-7-16(19)25-15/h3-7H,2,8-12H2,1H3,(H,21,24) ZKKDTKNDAYWGBN-UHFFFAOYSA-N 32456 piperazine amide, 4c Isoform Alpha-1 of Mitogen-activated protein kinase 10 (Alpha-1) 9-402] Homo sapiens 900 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2009.03.086 10.7270/Q2ST7N67 19433357 aid1799204 Shin, Y; Chen, W; Habel, J; Duckett, D; Ling, YY; Koenig, M; He, Y; Vojkovsky, T; LoGrasso, P; Kamenecka, TM The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=32456 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4017&target=Isoform+Alpha-1+of+Mitogen-activated+protein+kinase+10+%28Alpha-1%29+9-402%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=32456&enzyme=Isoform+Alpha-1+of+Mitogen-activated+protein+kinase+10+%28Alpha-1%29+9-402%5D&column=ki&startPg=0&Increment=50&submit=Search 44236944 85256323 ZINC62241835 1 MSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSE 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4L7F,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4X21,4Y46,4Y5H,4YR8,4Z9L,6EKD,6EMH,6EQ9,6ZR5,7KSI,7KSJ,7KSK,7ORE,7ORF,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 58321 CC(C)N1CCN(CC1)c1c(Cl)cccc1NC(=O)c1ccc(Br)o1 InChI=1S/C18H21BrClN3O2/c1-12(2)22-8-10-23(11-9-22)17-13(20)4-3-5-14(17)21-18(24)15-6-7-16(19)25-15/h3-7,12H,8-11H2,1-2H3,(H,21,24) JDJBKUSPSJTQRB-UHFFFAOYSA-N 32457 piperazine amide, 4d Isoform Alpha-1 of Mitogen-activated protein kinase 10 (Alpha-1) 9-402] Homo sapiens 2200 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2009.03.086 10.7270/Q2ST7N67 19433357 aid1799204 Shin, Y; Chen, W; Habel, J; Duckett, D; Ling, YY; Koenig, M; He, Y; Vojkovsky, T; LoGrasso, P; Kamenecka, TM The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=32457 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4017&target=Isoform+Alpha-1+of+Mitogen-activated+protein+kinase+10+%28Alpha-1%29+9-402%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=32457&enzyme=Isoform+Alpha-1+of+Mitogen-activated+protein+kinase+10+%28Alpha-1%29+9-402%5D&column=ki&startPg=0&Increment=50&submit=Search 44236945 85256324 ZINC62241837 1 MSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSE 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4L7F,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4X21,4Y46,4Y5H,4YR8,4Z9L,6EKD,6EMH,6EQ9,6ZR5,7KSI,7KSJ,7KSK,7ORE,7ORF,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 58322 Clc1cccc(NC(=O)c2ccc(Br)o2)c1N1CCN(CC=C)CC1 InChI=1S/C18H19BrClN3O2/c1-2-8-22-9-11-23(12-10-22)17-13(20)4-3-5-14(17)21-18(24)15-6-7-16(19)25-15/h2-7H,1,8-12H2,(H,21,24) DZCSIYOZJRMQKN-UHFFFAOYSA-N 32458 piperazine amide, 4e::piperazine amide, 6a Isoform Alpha-1 of Mitogen-activated protein kinase 10 (Alpha-1) 9-402] Homo sapiens 330 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2009.03.086 10.7270/Q2ST7N67 19433357 aid1799204 Shin, Y; Chen, W; Habel, J; Duckett, D; Ling, YY; Koenig, M; He, Y; Vojkovsky, T; LoGrasso, P; Kamenecka, TM The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=32458 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4017&target=Isoform+Alpha-1+of+Mitogen-activated+protein+kinase+10+%28Alpha-1%29+9-402%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=32458&enzyme=Isoform+Alpha-1+of+Mitogen-activated+protein+kinase+10+%28Alpha-1%29+9-402%5D&column=ki&startPg=0&Increment=50&submit=Search 25210489 85256325 ZINC59096344 1 MSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSE 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4L7F,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4X21,4Y46,4Y5H,4YR8,4Z9L,6EKD,6EMH,6EQ9,6ZR5,7KSI,7KSJ,7KSK,7ORE,7ORF,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 58323 CC(=C)CN1CCN(CC1)c1c(Cl)cccc1NC(=O)c1ccc(Br)o1 InChI=1S/C19H21BrClN3O2/c1-13(2)12-23-8-10-24(11-9-23)18-14(21)4-3-5-15(18)22-19(25)16-6-7-17(20)26-16/h3-7H,1,8-12H2,2H3,(H,22,25) AELOZOVEWBJDJP-UHFFFAOYSA-N 32459 piperazine amide, 4f Isoform Alpha-1 of Mitogen-activated protein kinase 10 (Alpha-1) 9-402] Homo sapiens 540 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2009.03.086 10.7270/Q2ST7N67 19433357 aid1799204 Shin, Y; Chen, W; Habel, J; Duckett, D; Ling, YY; Koenig, M; He, Y; Vojkovsky, T; LoGrasso, P; Kamenecka, TM The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=32459 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4017&target=Isoform+Alpha-1+of+Mitogen-activated+protein+kinase+10+%28Alpha-1%29+9-402%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=32459&enzyme=Isoform+Alpha-1+of+Mitogen-activated+protein+kinase+10+%28Alpha-1%29+9-402%5D&column=ki&startPg=0&Increment=50&submit=Search 44236946 85256326 ZINC62241838 1 MSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSE 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4L7F,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4X21,4Y46,4Y5H,4YR8,4Z9L,6EKD,6EMH,6EQ9,6ZR5,7KSI,7KSJ,7KSK,7ORE,7ORF,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 58324 Clc1cccc(NC(=O)c2ccc(Br)o2)c1N1CCN(CC#C)CC1 InChI=1S/C18H17BrClN3O2/c1-2-8-22-9-11-23(12-10-22)17-13(20)4-3-5-14(17)21-18(24)15-6-7-16(19)25-15/h1,3-7H,8-12H2,(H,21,24) MEFJFXHHHNDHEN-UHFFFAOYSA-N 32460 piperazine amide, 4g Isoform Alpha-1 of Mitogen-activated protein kinase 10 (Alpha-1) 9-402] Homo sapiens 160 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2009.03.086 10.7270/Q2ST7N67 19433357 aid1799204 Shin, Y; Chen, W; Habel, J; Duckett, D; Ling, YY; Koenig, M; He, Y; Vojkovsky, T; LoGrasso, P; Kamenecka, TM The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=32460 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4017&target=Isoform+Alpha-1+of+Mitogen-activated+protein+kinase+10+%28Alpha-1%29+9-402%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=32460&enzyme=Isoform+Alpha-1+of+Mitogen-activated+protein+kinase+10+%28Alpha-1%29+9-402%5D&column=ki&startPg=0&Increment=50&submit=Search JK3 3FV8 44224261 85256327 DB08021 ZINC39258074 1 MSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSE 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4L7F,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4X21,4Y46,4Y5H,4YR8,4Z9L,6EKD,6EMH,6EQ9,6ZR5,7KSI,7KSJ,7KSK,7ORE,7ORF,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 58325 Clc1cccc(NC(=O)c2ccc(Br)o2)c1N1CCN(CC1)C1CC1 InChI=1S/C18H19BrClN3O2/c19-16-7-6-15(25-16)18(24)21-14-3-1-2-13(20)17(14)23-10-8-22(9-11-23)12-4-5-12/h1-3,6-7,12H,4-5,8-11H2,(H,21,24) DWBUOTPQOTXBPX-UHFFFAOYSA-N 32461 piperazine amide, 4h Isoform Alpha-1 of Mitogen-activated protein kinase 10 (Alpha-1) 9-402] Homo sapiens 960 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2009.03.086 10.7270/Q2ST7N67 19433357 aid1799204 Shin, Y; Chen, W; Habel, J; Duckett, D; Ling, YY; Koenig, M; He, Y; Vojkovsky, T; LoGrasso, P; Kamenecka, TM The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=32461 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4017&target=Isoform+Alpha-1+of+Mitogen-activated+protein+kinase+10+%28Alpha-1%29+9-402%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=32461&enzyme=Isoform+Alpha-1+of+Mitogen-activated+protein+kinase+10+%28Alpha-1%29+9-402%5D&column=ki&startPg=0&Increment=50&submit=Search 44236947 85256328 ZINC62241844 1 MSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSE 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4L7F,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4X21,4Y46,4Y5H,4YR8,4Z9L,6EKD,6EMH,6EQ9,6ZR5,7KSI,7KSJ,7KSK,7ORE,7ORF,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 58326 Clc1cccc(NC(=O)c2ccc(Br)o2)c1N1CCN(Cc2ccco2)CC1 InChI=1S/C20H19BrClN3O3/c21-18-7-6-17(28-18)20(26)23-16-5-1-4-15(22)19(16)25-10-8-24(9-11-25)13-14-3-2-12-27-14/h1-7,12H,8-11,13H2,(H,23,26) RSBSYGXBCWDUEI-UHFFFAOYSA-N 32462 piperazine amide, 4i Isoform Alpha-1 of Mitogen-activated protein kinase 10 (Alpha-1) 9-402] Homo sapiens 250 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2009.03.086 10.7270/Q2ST7N67 19433357 aid1799204 Shin, Y; Chen, W; Habel, J; Duckett, D; Ling, YY; Koenig, M; He, Y; Vojkovsky, T; LoGrasso, P; Kamenecka, TM The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=32462 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4017&target=Isoform+Alpha-1+of+Mitogen-activated+protein+kinase+10+%28Alpha-1%29+9-402%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=32462&enzyme=Isoform+Alpha-1+of+Mitogen-activated+protein+kinase+10+%28Alpha-1%29+9-402%5D&column=ki&startPg=0&Increment=50&submit=Search 44236948 85256329 ZINC62241847 1 MSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSE 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4L7F,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4X21,4Y46,4Y5H,4YR8,4Z9L,6EKD,6EMH,6EQ9,6ZR5,7KSI,7KSJ,7KSK,7ORE,7ORF,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 58327 Clc1cccc(NC(=O)c2ccc(Br)o2)c1N1CCN(Cc2ccccc2)CC1 InChI=1S/C22H21BrClN3O2/c23-20-10-9-19(29-20)22(28)25-18-8-4-7-17(24)21(18)27-13-11-26(12-14-27)15-16-5-2-1-3-6-16/h1-10H,11-15H2,(H,25,28) GMRDEFSDKMMUMP-UHFFFAOYSA-N 32463 piperazine amide, 4j Isoform Alpha-1 of Mitogen-activated protein kinase 10 (Alpha-1) 9-402] Homo sapiens 1100 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2009.03.086 10.7270/Q2ST7N67 19433357 aid1799204 Shin, Y; Chen, W; Habel, J; Duckett, D; Ling, YY; Koenig, M; He, Y; Vojkovsky, T; LoGrasso, P; Kamenecka, TM The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=32463 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4017&target=Isoform+Alpha-1+of+Mitogen-activated+protein+kinase+10+%28Alpha-1%29+9-402%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=32463&enzyme=Isoform+Alpha-1+of+Mitogen-activated+protein+kinase+10+%28Alpha-1%29+9-402%5D&column=ki&startPg=0&Increment=50&submit=Search 44236949 85256330 ZINC62241852 1 MSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSE 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4L7F,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4X21,4Y46,4Y5H,4YR8,4Z9L,6EKD,6EMH,6EQ9,6ZR5,7KSI,7KSJ,7KSK,7ORE,7ORF,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 58328 Clc1cccc(NC(=O)c2ccc(Br)o2)c1N1CCN(CCc2ccccc2)CC1 InChI=1S/C23H23BrClN3O2/c24-21-10-9-20(30-21)23(29)26-19-8-4-7-18(25)22(19)28-15-13-27(14-16-28)12-11-17-5-2-1-3-6-17/h1-10H,11-16H2,(H,26,29) NIADURIGWRVMKM-UHFFFAOYSA-N 32464 piperazine amide, 4k Isoform Alpha-1 of Mitogen-activated protein kinase 10 (Alpha-1) 9-402] Homo sapiens 1400 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2009.03.086 10.7270/Q2ST7N67 19433357 aid1799204 Shin, Y; Chen, W; Habel, J; Duckett, D; Ling, YY; Koenig, M; He, Y; Vojkovsky, T; LoGrasso, P; Kamenecka, TM The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=32464 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4017&target=Isoform+Alpha-1+of+Mitogen-activated+protein+kinase+10+%28Alpha-1%29+9-402%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=32464&enzyme=Isoform+Alpha-1+of+Mitogen-activated+protein+kinase+10+%28Alpha-1%29+9-402%5D&column=ki&startPg=0&Increment=50&submit=Search 44236950 85256331 ZINC62241856 1 MSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSE 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4L7F,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4X21,4Y46,4Y5H,4YR8,4Z9L,6EKD,6EMH,6EQ9,6ZR5,7KSI,7KSJ,7KSK,7ORE,7ORF,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 58329 Clc1cccc(NC(=O)c2ccc(Br)o2)c1N1CCN(CC1)c1ccccn1 InChI=1S/C20H18BrClN4O2/c21-17-8-7-16(28-17)20(27)24-15-5-3-4-14(22)19(15)26-12-10-25(11-13-26)18-6-1-2-9-23-18/h1-9H,10-13H2,(H,24,27) IFLNPRMRVSMKNZ-UHFFFAOYSA-N 32465 piperazine amide, 4l Isoform Alpha-1 of Mitogen-activated protein kinase 10 (Alpha-1) 9-402] Homo sapiens 1000 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2009.03.086 10.7270/Q2ST7N67 19433357 aid1799204 Shin, Y; Chen, W; Habel, J; Duckett, D; Ling, YY; Koenig, M; He, Y; Vojkovsky, T; LoGrasso, P; Kamenecka, TM The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=32465 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4017&target=Isoform+Alpha-1+of+Mitogen-activated+protein+kinase+10+%28Alpha-1%29+9-402%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=32465&enzyme=Isoform+Alpha-1+of+Mitogen-activated+protein+kinase+10+%28Alpha-1%29+9-402%5D&column=ki&startPg=0&Increment=50&submit=Search 44236951 85256332 ZINC62241858 1 MSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSE 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4L7F,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4X21,4Y46,4Y5H,4YR8,4Z9L,6EKD,6EMH,6EQ9,6ZR5,7KSI,7KSJ,7KSK,7ORE,7ORF,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 58330 CC(=O)N1CCN(CC1)c1c(Cl)cccc1NC(=O)c1ccc(Br)o1 InChI=1S/C17H17BrClN3O3/c1-11(23)21-7-9-22(10-8-21)16-12(19)3-2-4-13(16)20-17(24)14-5-6-15(18)25-14/h2-6H,7-10H2,1H3,(H,20,24) VHPPODIXJOXBEV-UHFFFAOYSA-N 32466 piperazine amide, 4m Isoform Alpha-1 of Mitogen-activated protein kinase 10 (Alpha-1) 9-402] Homo sapiens 810 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2009.03.086 10.7270/Q2ST7N67 19433357 aid1799204 Shin, Y; Chen, W; Habel, J; Duckett, D; Ling, YY; Koenig, M; He, Y; Vojkovsky, T; LoGrasso, P; Kamenecka, TM The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=32466 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4017&target=Isoform+Alpha-1+of+Mitogen-activated+protein+kinase+10+%28Alpha-1%29+9-402%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=32466&enzyme=Isoform+Alpha-1+of+Mitogen-activated+protein+kinase+10+%28Alpha-1%29+9-402%5D&column=ki&startPg=0&Increment=50&submit=Search 17027307 85256333 ZINC09422342 1 MSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSE 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4L7F,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4X21,4Y46,4Y5H,4YR8,4Z9L,6EKD,6EMH,6EQ9,6ZR5,7KSI,7KSJ,7KSK,7ORE,7ORF,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 58331 FC(F)(F)C(=O)N1CCN(CC1)c1c(Cl)cccc1NC(=O)c1ccc(Br)o1 InChI=1S/C17H14BrClF3N3O3/c18-13-5-4-12(28-13)15(26)23-11-3-1-2-10(19)14(11)24-6-8-25(9-7-24)16(27)17(20,21)22/h1-5H,6-9H2,(H,23,26) RLYQVMMEYGXGGC-UHFFFAOYSA-N 32467 piperazine amide, 4n Isoform Alpha-1 of Mitogen-activated protein kinase 10 (Alpha-1) 9-402] Homo sapiens >20000 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2009.03.086 10.7270/Q2ST7N67 19433357 aid1799204 Shin, Y; Chen, W; Habel, J; Duckett, D; Ling, YY; Koenig, M; He, Y; Vojkovsky, T; LoGrasso, P; Kamenecka, TM The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=32467 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4017&target=Isoform+Alpha-1+of+Mitogen-activated+protein+kinase+10+%28Alpha-1%29+9-402%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=32467&enzyme=Isoform+Alpha-1+of+Mitogen-activated+protein+kinase+10+%28Alpha-1%29+9-402%5D&column=ki&startPg=0&Increment=50&submit=Search 44236952 85256334 ZINC62241860 1 MSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSE 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4L7F,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4X21,4Y46,4Y5H,4YR8,4Z9L,6EKD,6EMH,6EQ9,6ZR5,7KSI,7KSJ,7KSK,7ORE,7ORF,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 58332 CC(C)(C)OC(=O)N1CCN(CC1)c1c(Cl)cccc1NC(=O)c1ccc(Br)o1 InChI=1S/C20H23BrClN3O4/c1-20(2,3)29-19(27)25-11-9-24(10-12-25)17-13(22)5-4-6-14(17)23-18(26)15-7-8-16(21)28-15/h4-8H,9-12H2,1-3H3,(H,23,26) WEAWIXBUSLRHAI-UHFFFAOYSA-N 32468 piperazine amide, 4o Isoform Alpha-1 of Mitogen-activated protein kinase 10 (Alpha-1) 9-402] Homo sapiens >20000 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2009.03.086 10.7270/Q2ST7N67 19433357 aid1799204 Shin, Y; Chen, W; Habel, J; Duckett, D; Ling, YY; Koenig, M; He, Y; Vojkovsky, T; LoGrasso, P; Kamenecka, TM The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=32468 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4017&target=Isoform+Alpha-1+of+Mitogen-activated+protein+kinase+10+%28Alpha-1%29+9-402%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=32468&enzyme=Isoform+Alpha-1+of+Mitogen-activated+protein+kinase+10+%28Alpha-1%29+9-402%5D&column=ki&startPg=0&Increment=50&submit=Search 44236953 85256335 ZINC62241864 1 MSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSE 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4L7F,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4X21,4Y46,4Y5H,4YR8,4Z9L,6EKD,6EMH,6EQ9,6ZR5,7KSI,7KSJ,7KSK,7ORE,7ORF,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 58333 Cc1cccc(NC(=O)c2ccc(Br)o2)c1N1CCN(CC=C)CC1 InChI=1S/C19H22BrN3O2/c1-3-9-22-10-12-23(13-11-22)18-14(2)5-4-6-15(18)21-19(24)16-7-8-17(20)25-16/h3-8H,1,9-13H2,2H3,(H,21,24) OHYSHHMNDLYHFT-UHFFFAOYSA-N 32469 piperazine amide, 4p Isoform Alpha-1 of Mitogen-activated protein kinase 10 (Alpha-1) 9-402] Homo sapiens 200 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2009.03.086 10.7270/Q2ST7N67 19433357 aid1799204 Shin, Y; Chen, W; Habel, J; Duckett, D; Ling, YY; Koenig, M; He, Y; Vojkovsky, T; LoGrasso, P; Kamenecka, TM The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=32469 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4017&target=Isoform+Alpha-1+of+Mitogen-activated+protein+kinase+10+%28Alpha-1%29+9-402%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=32469&enzyme=Isoform+Alpha-1+of+Mitogen-activated+protein+kinase+10+%28Alpha-1%29+9-402%5D&column=ki&startPg=0&Increment=50&submit=Search 44236954 85256336 ZINC62241871 1 MSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSE 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4L7F,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4X21,4Y46,4Y5H,4YR8,4Z9L,6EKD,6EMH,6EQ9,6ZR5,7KSI,7KSJ,7KSK,7ORE,7ORF,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 58334 Fc1cccc(NC(=O)c2ccc(Br)o2)c1N1CCN(CC#C)CC1 InChI=1S/C18H17BrFN3O2/c1-2-8-22-9-11-23(12-10-22)17-13(20)4-3-5-14(17)21-18(24)15-6-7-16(19)25-15/h1,3-7H,8-12H2,(H,21,24) PPHUYGGBTOACGL-UHFFFAOYSA-N 32470 piperazine amide, 4q Isoform Alpha-1 of Mitogen-activated protein kinase 10 (Alpha-1) 9-402] Homo sapiens 290 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2009.03.086 10.7270/Q2ST7N67 19433357 aid1799204 Shin, Y; Chen, W; Habel, J; Duckett, D; Ling, YY; Koenig, M; He, Y; Vojkovsky, T; LoGrasso, P; Kamenecka, TM The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=32470 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4017&target=Isoform+Alpha-1+of+Mitogen-activated+protein+kinase+10+%28Alpha-1%29+9-402%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=32470&enzyme=Isoform+Alpha-1+of+Mitogen-activated+protein+kinase+10+%28Alpha-1%29+9-402%5D&column=ki&startPg=0&Increment=50&submit=Search 44236955 85256337 ZINC62241878 1 MSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSE 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4L7F,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4X21,4Y46,4Y5H,4YR8,4Z9L,6EKD,6EMH,6EQ9,6ZR5,7KSI,7KSJ,7KSK,7ORE,7ORF,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 58335 Brc1ccc(o1)C(=O)Nc1cccc(Br)c1N1CCN(CC=C)CC1 InChI=1S/C18H19Br2N3O2/c1-2-8-22-9-11-23(12-10-22)17-13(19)4-3-5-14(17)21-18(24)15-6-7-16(20)25-15/h2-7H,1,8-12H2,(H,21,24) KRMXSKGWRKZWPH-UHFFFAOYSA-N 32471 piperazine amide, 4r Isoform Alpha-1 of Mitogen-activated protein kinase 10 (Alpha-1) 9-402] Homo sapiens >20000 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2009.03.086 10.7270/Q2ST7N67 19433357 aid1799204 Shin, Y; Chen, W; Habel, J; Duckett, D; Ling, YY; Koenig, M; He, Y; Vojkovsky, T; LoGrasso, P; Kamenecka, TM The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=32471 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4017&target=Isoform+Alpha-1+of+Mitogen-activated+protein+kinase+10+%28Alpha-1%29+9-402%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=32471&enzyme=Isoform+Alpha-1+of+Mitogen-activated+protein+kinase+10+%28Alpha-1%29+9-402%5D&column=ki&startPg=0&Increment=50&submit=Search 44236956 85256338 ZINC62241884 1 MSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSE 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4L7F,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4X21,4Y46,4Y5H,4YR8,4Z9L,6EKD,6EMH,6EQ9,6ZR5,7KSI,7KSJ,7KSK,7ORE,7ORF,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 58336 FC(F)(F)c1cccc(NC(=O)c2ccc(Br)o2)c1N1CCN(CC=C)CC1 InChI=1S/C19H19BrF3N3O2/c1-2-8-25-9-11-26(12-10-25)17-13(19(21,22)23)4-3-5-14(17)24-18(27)15-6-7-16(20)28-15/h2-7H,1,8-12H2,(H,24,27) PIZUOGLRMJQXEK-UHFFFAOYSA-N 32472 piperazine amide, 4s Isoform Alpha-1 of Mitogen-activated protein kinase 10 (Alpha-1) 9-402] Homo sapiens >20000 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2009.03.086 10.7270/Q2ST7N67 19433357 aid1799204 Shin, Y; Chen, W; Habel, J; Duckett, D; Ling, YY; Koenig, M; He, Y; Vojkovsky, T; LoGrasso, P; Kamenecka, TM The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=32472 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4017&target=Isoform+Alpha-1+of+Mitogen-activated+protein+kinase+10+%28Alpha-1%29+9-402%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=32472&enzyme=Isoform+Alpha-1+of+Mitogen-activated+protein+kinase+10+%28Alpha-1%29+9-402%5D&column=ki&startPg=0&Increment=50&submit=Search 44236957 85256339 ZINC62241890 1 MSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSE 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4L7F,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4X21,4Y46,4Y5H,4YR8,4Z9L,6EKD,6EMH,6EQ9,6ZR5,7KSI,7KSJ,7KSK,7ORE,7ORF,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 58337 Brc1ccc(o1)C(=O)Nc1cccc(-c2ccccc2)c1N1CCN(CC=C)CC1 InChI=1S/C24H24BrN3O2/c1-2-13-27-14-16-28(17-15-27)23-19(18-7-4-3-5-8-18)9-6-10-20(23)26-24(29)21-11-12-22(25)30-21/h2-12H,1,13-17H2,(H,26,29) BHRVONRAOWCXOG-UHFFFAOYSA-N 32473 piperazine amide, 4t Isoform Alpha-1 of Mitogen-activated protein kinase 10 (Alpha-1) 9-402] Homo sapiens >20000 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2009.03.086 10.7270/Q2ST7N67 19433357 aid1799204 Shin, Y; Chen, W; Habel, J; Duckett, D; Ling, YY; Koenig, M; He, Y; Vojkovsky, T; LoGrasso, P; Kamenecka, TM The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=32473 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4017&target=Isoform+Alpha-1+of+Mitogen-activated+protein+kinase+10+%28Alpha-1%29+9-402%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=32473&enzyme=Isoform+Alpha-1+of+Mitogen-activated+protein+kinase+10+%28Alpha-1%29+9-402%5D&column=ki&startPg=0&Increment=50&submit=Search 44236958 85256340 ZINC62241893 1 MSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSE 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4L7F,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4X21,4Y46,4Y5H,4YR8,4Z9L,6EKD,6EMH,6EQ9,6ZR5,7KSI,7KSJ,7KSK,7ORE,7ORF,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 58338 Brc1ccc(o1)C(=O)Nc1cccc(Nc2ccccc2)c1N1CCN(CC=C)CC1 InChI=1S/C24H25BrN4O2/c1-2-13-28-14-16-29(17-15-28)23-19(26-18-7-4-3-5-8-18)9-6-10-20(23)27-24(30)21-11-12-22(25)31-21/h2-12,26H,1,13-17H2,(H,27,30) KXOWPDXQFCZQJI-UHFFFAOYSA-N 32474 piperazine amide, 4u Isoform Alpha-1 of Mitogen-activated protein kinase 10 (Alpha-1) 9-402] Homo sapiens >20000 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2009.03.086 10.7270/Q2ST7N67 19433357 aid1799204 Shin, Y; Chen, W; Habel, J; Duckett, D; Ling, YY; Koenig, M; He, Y; Vojkovsky, T; LoGrasso, P; Kamenecka, TM The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=32474 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4017&target=Isoform+Alpha-1+of+Mitogen-activated+protein+kinase+10+%28Alpha-1%29+9-402%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=32474&enzyme=Isoform+Alpha-1+of+Mitogen-activated+protein+kinase+10+%28Alpha-1%29+9-402%5D&column=ki&startPg=0&Increment=50&submit=Search 44236959 85256341 ZINC62241897 1 MSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSE 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4L7F,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4X21,4Y46,4Y5H,4YR8,4Z9L,6EKD,6EMH,6EQ9,6ZR5,7KSI,7KSJ,7KSK,7ORE,7ORF,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 58339 Clc1cccc(NC(=O)c2ccc(Br)o2)c1N1CCN(CC=C)CC1 InChI=1S/C18H19BrClN3O2/c1-2-8-22-9-11-23(12-10-22)17-13(20)4-3-5-14(17)21-18(24)15-6-7-16(19)25-15/h2-7H,1,8-12H2,(H,21,24) DZCSIYOZJRMQKN-UHFFFAOYSA-N 32458 piperazine amide, 4e::piperazine amide, 6a Isoform Alpha-1 of Mitogen-activated protein kinase 10 (Alpha-1) 9-402] Homo sapiens 1260 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2009.03.086 10.7270/Q2ST7N67 19433357 aid1799204 Shin, Y; Chen, W; Habel, J; Duckett, D; Ling, YY; Koenig, M; He, Y; Vojkovsky, T; LoGrasso, P; Kamenecka, TM The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=32458 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4017&target=Isoform+Alpha-1+of+Mitogen-activated+protein+kinase+10+%28Alpha-1%29+9-402%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=32458&enzyme=Isoform+Alpha-1+of+Mitogen-activated+protein+kinase+10+%28Alpha-1%29+9-402%5D&column=ki&startPg=0&Increment=50&submit=Search 25210489 85256325 ZINC59096344 1 MSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSE 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4L7F,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4X21,4Y46,4Y5H,4YR8,4Z9L,6EKD,6EMH,6EQ9,6ZR5,7KSI,7KSJ,7KSK,7ORE,7ORF,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 58340 Clc1cccc(NC(=O)c2cnc(Br)s2)c1N1CCN(CC=C)CC1 InChI=1S/C17H18BrClN4OS/c1-2-6-22-7-9-23(10-8-22)15-12(19)4-3-5-13(15)21-16(24)14-11-20-17(18)25-14/h2-5,11H,1,6-10H2,(H,21,24) INGLARCWUNLRGV-UHFFFAOYSA-N 32476 piperazine amide, 6b Isoform Alpha-1 of Mitogen-activated protein kinase 10 (Alpha-1) 9-402] Homo sapiens 310 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2009.03.086 10.7270/Q2ST7N67 19433357 aid1799204 Shin, Y; Chen, W; Habel, J; Duckett, D; Ling, YY; Koenig, M; He, Y; Vojkovsky, T; LoGrasso, P; Kamenecka, TM The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=32476 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4017&target=Isoform+Alpha-1+of+Mitogen-activated+protein+kinase+10+%28Alpha-1%29+9-402%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=32476&enzyme=Isoform+Alpha-1+of+Mitogen-activated+protein+kinase+10+%28Alpha-1%29+9-402%5D&column=ki&startPg=0&Increment=50&submit=Search 44236960 85256343 ZINC62241900 1 MSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSE 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4L7F,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4X21,4Y46,4Y5H,4YR8,4Z9L,6EKD,6EMH,6EQ9,6ZR5,7KSI,7KSJ,7KSK,7ORE,7ORF,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 58341 Clc1cccc(NC(=O)c2nc(Br)cs2)c1N1CCN(CC=C)CC1 InChI=1S/C17H18BrClN4OS/c1-2-6-22-7-9-23(10-8-22)15-12(19)4-3-5-13(15)20-16(24)17-21-14(18)11-25-17/h2-5,11H,1,6-10H2,(H,20,24) XXNJHIJZQXGDEO-UHFFFAOYSA-N 32477 piperazine amide, 6c Isoform Alpha-1 of Mitogen-activated protein kinase 10 (Alpha-1) 9-402] Homo sapiens 1800 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2009.03.086 10.7270/Q2ST7N67 19433357 aid1799204 Shin, Y; Chen, W; Habel, J; Duckett, D; Ling, YY; Koenig, M; He, Y; Vojkovsky, T; LoGrasso, P; Kamenecka, TM The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=32477 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4017&target=Isoform+Alpha-1+of+Mitogen-activated+protein+kinase+10+%28Alpha-1%29+9-402%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=32477&enzyme=Isoform+Alpha-1+of+Mitogen-activated+protein+kinase+10+%28Alpha-1%29+9-402%5D&column=ki&startPg=0&Increment=50&submit=Search 44236961 85256344 ZINC62241903 1 MSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSE 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4L7F,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4X21,4Y46,4Y5H,4YR8,4Z9L,6EKD,6EMH,6EQ9,6ZR5,7KSI,7KSJ,7KSK,7ORE,7ORF,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 58342 Clc1cccc(NC(=O)c2cscn2)c1N1CCN(CC=C)CC1 InChI=1S/C17H19ClN4OS/c1-2-6-21-7-9-22(10-8-21)16-13(18)4-3-5-14(16)20-17(23)15-11-24-12-19-15/h2-5,11-12H,1,6-10H2,(H,20,23) HUGQVXKORQQUFW-UHFFFAOYSA-N 32478 piperazine amide, 6d Isoform Alpha-1 of Mitogen-activated protein kinase 10 (Alpha-1) 9-402] Homo sapiens 2300 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2009.03.086 10.7270/Q2ST7N67 19433357 aid1799204 Shin, Y; Chen, W; Habel, J; Duckett, D; Ling, YY; Koenig, M; He, Y; Vojkovsky, T; LoGrasso, P; Kamenecka, TM The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=32478 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4017&target=Isoform+Alpha-1+of+Mitogen-activated+protein+kinase+10+%28Alpha-1%29+9-402%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=32478&enzyme=Isoform+Alpha-1+of+Mitogen-activated+protein+kinase+10+%28Alpha-1%29+9-402%5D&column=ki&startPg=0&Increment=50&submit=Search 44236962 85256345 ZINC62241907 1 MSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSE 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4L7F,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4X21,4Y46,4Y5H,4YR8,4Z9L,6EKD,6EMH,6EQ9,6ZR5,7KSI,7KSJ,7KSK,7ORE,7ORF,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 58343 Clc1cccc(NC(=O)c2ccno2)c1N1CCN(CC=C)CC1 InChI=1S/C17H19ClN4O2/c1-2-8-21-9-11-22(12-10-21)16-13(18)4-3-5-14(16)20-17(23)15-6-7-19-24-15/h2-7H,1,8-12H2,(H,20,23) DZSWJFCIVCZRGJ-UHFFFAOYSA-N 32479 piperazine amide, 6f Isoform Alpha-1 of Mitogen-activated protein kinase 10 (Alpha-1) 9-402] Homo sapiens 5000 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2009.03.086 10.7270/Q2ST7N67 19433357 aid1799204 Shin, Y; Chen, W; Habel, J; Duckett, D; Ling, YY; Koenig, M; He, Y; Vojkovsky, T; LoGrasso, P; Kamenecka, TM The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=32479 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4017&target=Isoform+Alpha-1+of+Mitogen-activated+protein+kinase+10+%28Alpha-1%29+9-402%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=32479&enzyme=Isoform+Alpha-1+of+Mitogen-activated+protein+kinase+10+%28Alpha-1%29+9-402%5D&column=ki&startPg=0&Increment=50&submit=Search 44236963 85256346 ZINC62241910 1 MSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSE 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4L7F,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4X21,4Y46,4Y5H,4YR8,4Z9L,6EKD,6EMH,6EQ9,6ZR5,7KSI,7KSJ,7KSK,7ORE,7ORF,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 58344 Clc1cccc(NC(=O)c2ccc[nH]2)c1N1CCN(CC=C)CC1 InChI=1S/C18H21ClN4O/c1-2-9-22-10-12-23(13-11-22)17-14(19)5-3-6-15(17)21-18(24)16-7-4-8-20-16/h2-8,20H,1,9-13H2,(H,21,24) NGHYJTPCQZDPGC-UHFFFAOYSA-N 32480 piperazine amide, 6g Isoform Alpha-1 of Mitogen-activated protein kinase 10 (Alpha-1) 9-402] Homo sapiens 8900 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2009.03.086 10.7270/Q2ST7N67 19433357 aid1799204 Shin, Y; Chen, W; Habel, J; Duckett, D; Ling, YY; Koenig, M; He, Y; Vojkovsky, T; LoGrasso, P; Kamenecka, TM The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=32480 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4017&target=Isoform+Alpha-1+of+Mitogen-activated+protein+kinase+10+%28Alpha-1%29+9-402%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=32480&enzyme=Isoform+Alpha-1+of+Mitogen-activated+protein+kinase+10+%28Alpha-1%29+9-402%5D&column=ki&startPg=0&Increment=50&submit=Search 44236964 85256347 ZINC62241917 1 MSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSE 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4L7F,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4X21,4Y46,4Y5H,4YR8,4Z9L,6EKD,6EMH,6EQ9,6ZR5,7KSI,7KSJ,7KSK,7ORE,7ORF,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 58345 Cc1nc(cs1)C(=O)Nc1cccc(Cl)c1N1CCN(CC=C)CC1 InChI=1S/C18H21ClN4OS/c1-3-7-22-8-10-23(11-9-22)17-14(19)5-4-6-15(17)21-18(24)16-12-25-13(2)20-16/h3-6,12H,1,7-11H2,2H3,(H,21,24) QOCVFDFVIYEUGD-UHFFFAOYSA-N 32481 piperazine amide, 6h Isoform Alpha-1 of Mitogen-activated protein kinase 10 (Alpha-1) 9-402] Homo sapiens 5800 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2009.03.086 10.7270/Q2ST7N67 19433357 aid1799204 Shin, Y; Chen, W; Habel, J; Duckett, D; Ling, YY; Koenig, M; He, Y; Vojkovsky, T; LoGrasso, P; Kamenecka, TM The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=32481 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4017&target=Isoform+Alpha-1+of+Mitogen-activated+protein+kinase+10+%28Alpha-1%29+9-402%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=32481&enzyme=Isoform+Alpha-1+of+Mitogen-activated+protein+kinase+10+%28Alpha-1%29+9-402%5D&column=ki&startPg=0&Increment=50&submit=Search 44236965 85256348 ZINC62241922 1 MSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSE 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4L7F,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4X21,4Y46,4Y5H,4YR8,4Z9L,6EKD,6EMH,6EQ9,6ZR5,7KSI,7KSJ,7KSK,7ORE,7ORF,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 58346 Clc1cccc(NC(=O)c2cccc(Br)n2)c1N1CCN(CC=C)CC1 InChI=1S/C19H20BrClN4O/c1-2-9-24-10-12-25(13-11-24)18-14(21)5-3-6-15(18)23-19(26)16-7-4-8-17(20)22-16/h2-8H,1,9-13H2,(H,23,26) DMGNBBQZNYEGLE-UHFFFAOYSA-N 32482 piperazine amide, 6i Isoform Alpha-1 of Mitogen-activated protein kinase 10 (Alpha-1) 9-402] Homo sapiens 2000 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2009.03.086 10.7270/Q2ST7N67 19433357 aid1799204 Shin, Y; Chen, W; Habel, J; Duckett, D; Ling, YY; Koenig, M; He, Y; Vojkovsky, T; LoGrasso, P; Kamenecka, TM The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=32482 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4017&target=Isoform+Alpha-1+of+Mitogen-activated+protein+kinase+10+%28Alpha-1%29+9-402%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=32482&enzyme=Isoform+Alpha-1+of+Mitogen-activated+protein+kinase+10+%28Alpha-1%29+9-402%5D&column=ki&startPg=0&Increment=50&submit=Search 44236966 85256349 ZINC62241927 1 MSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSE 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4L7F,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4X21,4Y46,4Y5H,4YR8,4Z9L,6EKD,6EMH,6EQ9,6ZR5,7KSI,7KSJ,7KSK,7ORE,7ORF,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 58347 Cc1cccc(n1)C(=O)Nc1cccc(Cl)c1N1CCN(CC=C)CC1 InChI=1S/C20H23ClN4O/c1-3-10-24-11-13-25(14-12-24)19-16(21)7-5-8-17(19)23-20(26)18-9-4-6-15(2)22-18/h3-9H,1,10-14H2,2H3,(H,23,26) ACLOKVWLCNWXDQ-UHFFFAOYSA-N 32483 piperazine amide, 6j Isoform Alpha-1 of Mitogen-activated protein kinase 10 (Alpha-1) 9-402] Homo sapiens 2000 Curated from the literature by BindingDB 10.1016/j.bmcl.2009.03.086 10.7270/Q2ST7N67 19433357 aid1799204 Shin, Y; Chen, W; Habel, J; Duckett, D; Ling, YY; Koenig, M; He, Y; Vojkovsky, T; LoGrasso, P; Kamenecka, TM The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=32483 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4017&target=Isoform+Alpha-1+of+Mitogen-activated+protein+kinase+10+%28Alpha-1%29+9-402%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=32483&enzyme=Isoform+Alpha-1+of+Mitogen-activated+protein+kinase+10+%28Alpha-1%29+9-402%5D&column=ki&startPg=0&Increment=50&submit=Search 44236967 85256350 ZINC62241929 1 MSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSE 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4L7F,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4X21,4Y46,4Y5H,4YR8,4Z9L,6EKD,6EMH,6EQ9,6ZR5,7KSI,7KSJ,7KSK,7ORE,7ORF,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 58348 Clc1cccc(NC(=O)c2cccc(Br)c2)c1N1CCN(CC=C)CC1 InChI=1S/C20H21BrClN3O/c1-2-9-24-10-12-25(13-11-24)19-17(22)7-4-8-18(19)23-20(26)15-5-3-6-16(21)14-15/h2-8,14H,1,9-13H2,(H,23,26) WXYKZRGWZIBZOK-UHFFFAOYSA-N 32484 piperazine amide, 6k Isoform Alpha-1 of Mitogen-activated protein kinase 10 (Alpha-1) 9-402] Homo sapiens 6400 Curated from the literature by BindingDB 10.1016/j.bmcl.2009.03.086 10.7270/Q2ST7N67 19433357 aid1799204 Shin, Y; Chen, W; Habel, J; Duckett, D; Ling, YY; Koenig, M; He, Y; Vojkovsky, T; LoGrasso, P; Kamenecka, TM The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=32484 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4017&target=Isoform+Alpha-1+of+Mitogen-activated+protein+kinase+10+%28Alpha-1%29+9-402%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=32484&enzyme=Isoform+Alpha-1+of+Mitogen-activated+protein+kinase+10+%28Alpha-1%29+9-402%5D&column=ki&startPg=0&Increment=50&submit=Search 44236968 85256351 ZINC62241930 1 MSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSE 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4L7F,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4X21,4Y46,4Y5H,4YR8,4Z9L,6EKD,6EMH,6EQ9,6ZR5,7KSI,7KSJ,7KSK,7ORE,7ORF,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 58349 Clc1cccc(NC(=O)c2ncccn2)c1N1CCN(CC=C)CC1 InChI=1S/C18H20ClN5O/c1-2-9-23-10-12-24(13-11-23)16-14(19)5-3-6-15(16)22-18(25)17-20-7-4-8-21-17/h2-8H,1,9-13H2,(H,22,25) GBXUSRNOXVCLLF-UHFFFAOYSA-N 32485 piperazine amide, 6l Isoform Alpha-1 of Mitogen-activated protein kinase 10 (Alpha-1) 9-402] Homo sapiens >20000 Curated from the literature by BindingDB 10.1016/j.bmcl.2009.03.086 10.7270/Q2ST7N67 19433357 aid1799204 Shin, Y; Chen, W; Habel, J; Duckett, D; Ling, YY; Koenig, M; He, Y; Vojkovsky, T; LoGrasso, P; Kamenecka, TM The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=32485 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4017&target=Isoform+Alpha-1+of+Mitogen-activated+protein+kinase+10+%28Alpha-1%29+9-402%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=32485&enzyme=Isoform+Alpha-1+of+Mitogen-activated+protein+kinase+10+%28Alpha-1%29+9-402%5D&column=ki&startPg=0&Increment=50&submit=Search 44236969 85256352 ZINC62241934 1 MSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSE 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4L7F,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4X21,4Y46,4Y5H,4YR8,4Z9L,6EKD,6EMH,6EQ9,6ZR5,7KSI,7KSJ,7KSK,7ORE,7ORF,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 58350 Clc1cccc(NC(=O)c2ccc(cn2)C#N)c1N1CCN(CC=C)CC1 InChI=1S/C20H20ClN5O/c1-2-8-25-9-11-26(12-10-25)19-16(21)4-3-5-17(19)24-20(27)18-7-6-15(13-22)14-23-18/h2-7,14H,1,8-12H2,(H,24,27) JSGWRVWXKJDFER-UHFFFAOYSA-N 32486 piperazine amide, 6m Isoform Alpha-1 of Mitogen-activated protein kinase 10 (Alpha-1) 9-402] Homo sapiens >20000 Curated from the literature by BindingDB 10.1016/j.bmcl.2009.03.086 10.7270/Q2ST7N67 19433357 aid1799204 Shin, Y; Chen, W; Habel, J; Duckett, D; Ling, YY; Koenig, M; He, Y; Vojkovsky, T; LoGrasso, P; Kamenecka, TM The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=32486 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4017&target=Isoform+Alpha-1+of+Mitogen-activated+protein+kinase+10+%28Alpha-1%29+9-402%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=32486&enzyme=Isoform+Alpha-1+of+Mitogen-activated+protein+kinase+10+%28Alpha-1%29+9-402%5D&column=ki&startPg=0&Increment=50&submit=Search 44236970 85256353 ZINC62241937 1 MSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSE 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4L7F,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4X21,4Y46,4Y5H,4YR8,4Z9L,6EKD,6EMH,6EQ9,6ZR5,7KSI,7KSJ,7KSK,7ORE,7ORF,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 58351 Cc1cccc(NC(=O)c2ccc(Br)o2)c1N1CCC2(CC1)OCCO2 InChI=1S/C19H21BrN2O4/c1-13-3-2-4-14(21-18(23)15-5-6-16(20)26-15)17(13)22-9-7-19(8-10-22)24-11-12-25-19/h2-6H,7-12H2,1H3,(H,21,23) NJOQHORLRFTUGK-UHFFFAOYSA-N 32487 aryl piperidine, 9b Isoform Alpha-1 of Mitogen-activated protein kinase 10 (Alpha-1) 9-402] Homo sapiens 60 Curated from the literature by BindingDB 10.1016/j.bmcl.2009.03.086 10.7270/Q2ST7N67 19433357 aid1799204 Shin, Y; Chen, W; Habel, J; Duckett, D; Ling, YY; Koenig, M; He, Y; Vojkovsky, T; LoGrasso, P; Kamenecka, TM The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=32487 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4017&target=Isoform+Alpha-1+of+Mitogen-activated+protein+kinase+10+%28Alpha-1%29+9-402%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=32487&enzyme=Isoform+Alpha-1+of+Mitogen-activated+protein+kinase+10+%28Alpha-1%29+9-402%5D&column=ki&startPg=0&Increment=50&submit=Search 44236971 85256354 ZINC62241942 1 MSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSE 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4L7F,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4X21,4Y46,4Y5H,4YR8,4Z9L,6EKD,6EMH,6EQ9,6ZR5,7KSI,7KSJ,7KSK,7ORE,7ORF,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 58352 Cc1cccc(NC(=O)c2ccc(Cl)o2)c1N1CCC2(CC1)OCCO2 InChI=1S/C19H21ClN2O4/c1-13-3-2-4-14(21-18(23)15-5-6-16(20)26-15)17(13)22-9-7-19(8-10-22)24-11-12-25-19/h2-6H,7-12H2,1H3,(H,21,23) YRFPTZPAVDAEDW-UHFFFAOYSA-N 32488 aryl piperidine, 9d Isoform Alpha-1 of Mitogen-activated protein kinase 10 (Alpha-1) 9-402] Homo sapiens 80 Curated from the literature by BindingDB 10.1016/j.bmcl.2009.03.086 10.7270/Q2ST7N67 19433357 aid1799204 Shin, Y; Chen, W; Habel, J; Duckett, D; Ling, YY; Koenig, M; He, Y; Vojkovsky, T; LoGrasso, P; Kamenecka, TM The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=32488 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4017&target=Isoform+Alpha-1+of+Mitogen-activated+protein+kinase+10+%28Alpha-1%29+9-402%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=32488&enzyme=Isoform+Alpha-1+of+Mitogen-activated+protein+kinase+10+%28Alpha-1%29+9-402%5D&column=ki&startPg=0&Increment=50&submit=Search 44236972 85256355 ZINC62241945 1 MSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSE 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4L7F,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4X21,4Y46,4Y5H,4YR8,4Z9L,6EKD,6EMH,6EQ9,6ZR5,7KSI,7KSJ,7KSK,7ORE,7ORF,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 58353 Cc1cccc(NC(=O)c2ccc(F)o2)c1N1CCC2(CC1)OCCO2 InChI=1S/C19H21FN2O4/c1-13-3-2-4-14(21-18(23)15-5-6-16(20)26-15)17(13)22-9-7-19(8-10-22)24-11-12-25-19/h2-6H,7-12H2,1H3,(H,21,23) SHBXAJXKKQHYFU-UHFFFAOYSA-N 32489 aryl piperidine, 9e Isoform Alpha-1 of Mitogen-activated protein kinase 10 (Alpha-1) 9-402] Homo sapiens 410 Curated from the literature by BindingDB 10.1016/j.bmcl.2009.03.086 10.7270/Q2ST7N67 19433357 aid1799204 Shin, Y; Chen, W; Habel, J; Duckett, D; Ling, YY; Koenig, M; He, Y; Vojkovsky, T; LoGrasso, P; Kamenecka, TM The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=32489 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4017&target=Isoform+Alpha-1+of+Mitogen-activated+protein+kinase+10+%28Alpha-1%29+9-402%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=32489&enzyme=Isoform+Alpha-1+of+Mitogen-activated+protein+kinase+10+%28Alpha-1%29+9-402%5D&column=ki&startPg=0&Increment=50&submit=Search 44236973 85256356 ZINC62241949 1 MSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSE 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4L7F,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4X21,4Y46,4Y5H,4YR8,4Z9L,6EKD,6EMH,6EQ9,6ZR5,7KSI,7KSJ,7KSK,7ORE,7ORF,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 58354 Cc1cccc(NC(=O)c2ccc(o2)C#N)c1N1CCC2(CC1)OCCO2 InChI=1S/C20H21N3O4/c1-14-3-2-4-16(22-19(24)17-6-5-15(13-21)27-17)18(14)23-9-7-20(8-10-23)25-11-12-26-20/h2-6H,7-12H2,1H3,(H,22,24) SPOFWIHFQUTCOI-UHFFFAOYSA-N 32490 aryl piperidine, 9f Isoform Alpha-1 of Mitogen-activated protein kinase 10 (Alpha-1) 9-402] Homo sapiens 210 Curated from the literature by BindingDB 10.1016/j.bmcl.2009.03.086 10.7270/Q2ST7N67 19433357 aid1799204 Shin, Y; Chen, W; Habel, J; Duckett, D; Ling, YY; Koenig, M; He, Y; Vojkovsky, T; LoGrasso, P; Kamenecka, TM The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=32490 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4017&target=Isoform+Alpha-1+of+Mitogen-activated+protein+kinase+10+%28Alpha-1%29+9-402%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=32490&enzyme=Isoform+Alpha-1+of+Mitogen-activated+protein+kinase+10+%28Alpha-1%29+9-402%5D&column=ki&startPg=0&Increment=50&submit=Search 44236974 85256357 ZINC62241953 1 MSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSE 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4L7F,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4X21,4Y46,4Y5H,4YR8,4Z9L,6EKD,6EMH,6EQ9,6ZR5,7KSI,7KSJ,7KSK,7ORE,7ORF,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 58355 Cc1ccc(o1)C(=O)Nc1cccc(C)c1N1CCC2(CC1)OCCO2 InChI=1S/C20H24N2O4/c1-14-4-3-5-16(21-19(23)17-7-6-15(2)26-17)18(14)22-10-8-20(9-11-22)24-12-13-25-20/h3-7H,8-13H2,1-2H3,(H,21,23) BHMYLUVZDOIZTR-UHFFFAOYSA-N 32491 aryl piperidine, 9g Isoform Alpha-1 of Mitogen-activated protein kinase 10 (Alpha-1) 9-402] Homo sapiens 530 Curated from the literature by BindingDB 10.1016/j.bmcl.2009.03.086 10.7270/Q2ST7N67 19433357 aid1799204 Shin, Y; Chen, W; Habel, J; Duckett, D; Ling, YY; Koenig, M; He, Y; Vojkovsky, T; LoGrasso, P; Kamenecka, TM The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=32491 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4017&target=Isoform+Alpha-1+of+Mitogen-activated+protein+kinase+10+%28Alpha-1%29+9-402%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=32491&enzyme=Isoform+Alpha-1+of+Mitogen-activated+protein+kinase+10+%28Alpha-1%29+9-402%5D&column=ki&startPg=0&Increment=50&submit=Search 44236975 85256358 ZINC62241957 1 MSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSE 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4L7F,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4X21,4Y46,4Y5H,4YR8,4Z9L,6EKD,6EMH,6EQ9,6ZR5,7KSI,7KSJ,7KSK,7ORE,7ORF,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 58356 Cc1cccc(NC(=O)c2ccc(o2)C(F)F)c1N1CCC2(CC1)OCCO2 InChI=1S/C20H22F2N2O4/c1-13-3-2-4-14(23-19(25)16-6-5-15(28-16)18(21)22)17(13)24-9-7-20(8-10-24)26-11-12-27-20/h2-6,18H,7-12H2,1H3,(H,23,25) RTMJIFPHPQZXEZ-UHFFFAOYSA-N 32492 aryl piperidine, 9h Isoform Alpha-1 of Mitogen-activated protein kinase 10 (Alpha-1) 9-402] Homo sapiens 350 Curated from the literature by BindingDB 10.1016/j.bmcl.2009.03.086 10.7270/Q2ST7N67 19433357 aid1799204 Shin, Y; Chen, W; Habel, J; Duckett, D; Ling, YY; Koenig, M; He, Y; Vojkovsky, T; LoGrasso, P; Kamenecka, TM The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=32492 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4017&target=Isoform+Alpha-1+of+Mitogen-activated+protein+kinase+10+%28Alpha-1%29+9-402%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=32492&enzyme=Isoform+Alpha-1+of+Mitogen-activated+protein+kinase+10+%28Alpha-1%29+9-402%5D&column=ki&startPg=0&Increment=50&submit=Search 44236976 85256359 ZINC62241961 1 MSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSE 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4L7F,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4X21,4Y46,4Y5H,4YR8,4Z9L,6EKD,6EMH,6EQ9,6ZR5,7KSI,7KSJ,7KSK,7ORE,7ORF,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 58357 CCc1ccc(o1)C(=O)Nc1cccc(C)c1N1CCC2(CC1)OCCO2 InChI=1S/C21H26N2O4/c1-3-16-7-8-18(27-16)20(24)22-17-6-4-5-15(2)19(17)23-11-9-21(10-12-23)25-13-14-26-21/h4-8H,3,9-14H2,1-2H3,(H,22,24) SGKOQVKJURANLQ-UHFFFAOYSA-N 32493 aryl piperidine, 9i Isoform Alpha-1 of Mitogen-activated protein kinase 10 (Alpha-1) 9-402] Homo sapiens 1000 Curated from the literature by BindingDB 10.1016/j.bmcl.2009.03.086 10.7270/Q2ST7N67 19433357 aid1799204 Shin, Y; Chen, W; Habel, J; Duckett, D; Ling, YY; Koenig, M; He, Y; Vojkovsky, T; LoGrasso, P; Kamenecka, TM The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=32493 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4017&target=Isoform+Alpha-1+of+Mitogen-activated+protein+kinase+10+%28Alpha-1%29+9-402%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=32493&enzyme=Isoform+Alpha-1+of+Mitogen-activated+protein+kinase+10+%28Alpha-1%29+9-402%5D&column=ki&startPg=0&Increment=50&submit=Search 44236977 85256360 ZINC62241965 1 MSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSE 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4L7F,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4X21,4Y46,4Y5H,4YR8,4Z9L,6EKD,6EMH,6EQ9,6ZR5,7KSI,7KSJ,7KSK,7ORE,7ORF,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 58358 CC#Cc1ccc(o1)C(=O)Nc1cccc(C)c1N1CCC2(CC1)OCCO2 InChI=1S/C22H24N2O4/c1-3-5-17-8-9-19(28-17)21(25)23-18-7-4-6-16(2)20(18)24-12-10-22(11-13-24)26-14-15-27-22/h4,6-9H,10-15H2,1-2H3,(H,23,25) JUCZVVOFLZHKJP-UHFFFAOYSA-N 32494 aryl piperidine, 9j Isoform Alpha-1 of Mitogen-activated protein kinase 10 (Alpha-1) 9-402] Homo sapiens 110 Curated from the literature by BindingDB 10.1016/j.bmcl.2009.03.086 10.7270/Q2ST7N67 19433357 aid1799204 Shin, Y; Chen, W; Habel, J; Duckett, D; Ling, YY; Koenig, M; He, Y; Vojkovsky, T; LoGrasso, P; Kamenecka, TM The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=32494 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4017&target=Isoform+Alpha-1+of+Mitogen-activated+protein+kinase+10+%28Alpha-1%29+9-402%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=32494&enzyme=Isoform+Alpha-1+of+Mitogen-activated+protein+kinase+10+%28Alpha-1%29+9-402%5D&column=ki&startPg=0&Increment=50&submit=Search 44236978 85256361 ZINC62241968 1 MSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSE 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4L7F,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4X21,4Y46,4Y5H,4YR8,4Z9L,6EKD,6EMH,6EQ9,6ZR5,7KSI,7KSJ,7KSK,7ORE,7ORF,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 58359 Cc1cccc(NC(=O)c2ccc(Cc3ccccc3)o2)c1N1CCC2(CC1)OCCO2 InChI=1S/C26H28N2O4/c1-19-6-5-9-22(24(19)28-14-12-26(13-15-28)30-16-17-31-26)27-25(29)23-11-10-21(32-23)18-20-7-3-2-4-8-20/h2-11H,12-18H2,1H3,(H,27,29) GWNXTVDEGCQLHU-UHFFFAOYSA-N 32495 aryl piperidine, 9k Isoform Alpha-1 of Mitogen-activated protein kinase 10 (Alpha-1) 9-402] Homo sapiens 4800 Curated from the literature by BindingDB 10.1016/j.bmcl.2009.03.086 10.7270/Q2ST7N67 19433357 aid1799204 Shin, Y; Chen, W; Habel, J; Duckett, D; Ling, YY; Koenig, M; He, Y; Vojkovsky, T; LoGrasso, P; Kamenecka, TM The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=32495 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4017&target=Isoform+Alpha-1+of+Mitogen-activated+protein+kinase+10+%28Alpha-1%29+9-402%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=32495&enzyme=Isoform+Alpha-1+of+Mitogen-activated+protein+kinase+10+%28Alpha-1%29+9-402%5D&column=ki&startPg=0&Increment=50&submit=Search 44236979 85256362 ZINC62241971 1 MSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSE 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4L7F,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4X21,4Y46,4Y5H,4YR8,4Z9L,6EKD,6EMH,6EQ9,6ZR5,7KSI,7KSJ,7KSK,7ORE,7ORF,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 58360 COc1ccc(o1)C(=O)Nc1cccc(C)c1N1CCC2(CC1)OCCO2 InChI=1S/C20H24N2O5/c1-14-4-3-5-15(21-19(23)16-6-7-17(24-2)27-16)18(14)22-10-8-20(9-11-22)25-12-13-26-20/h3-7H,8-13H2,1-2H3,(H,21,23) VMQZTUVADKYPAR-UHFFFAOYSA-N 32496 aryl piperidine, 9l Isoform Alpha-1 of Mitogen-activated protein kinase 10 (Alpha-1) 9-402] Homo sapiens 620 Curated from the literature by BindingDB 10.1016/j.bmcl.2009.03.086 10.7270/Q2ST7N67 19433357 aid1799204 Shin, Y; Chen, W; Habel, J; Duckett, D; Ling, YY; Koenig, M; He, Y; Vojkovsky, T; LoGrasso, P; Kamenecka, TM The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=32496 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4017&target=Isoform+Alpha-1+of+Mitogen-activated+protein+kinase+10+%28Alpha-1%29+9-402%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=32496&enzyme=Isoform+Alpha-1+of+Mitogen-activated+protein+kinase+10+%28Alpha-1%29+9-402%5D&column=ki&startPg=0&Increment=50&submit=Search 44236980 85256363 ZINC62241976 1 MSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSE 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4L7F,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4X21,4Y46,4Y5H,4YR8,4Z9L,6EKD,6EMH,6EQ9,6ZR5,7KSI,7KSJ,7KSK,7ORE,7ORF,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 58361 CC(=O)Nc1ccc(o1)C(=O)Nc1cccc(C)c1N1CCC2(CC1)OCCO2 InChI=1S/C21H25N3O5/c1-14-4-3-5-16(23-20(26)17-6-7-18(29-17)22-15(2)25)19(14)24-10-8-21(9-11-24)27-12-13-28-21/h3-7H,8-13H2,1-2H3,(H,22,25)(H,23,26) MXIMLBXMMQOIHB-UHFFFAOYSA-N 32497 aryl piperidine, 9m Isoform Alpha-1 of Mitogen-activated protein kinase 10 (Alpha-1) 9-402] Homo sapiens 11000 Curated from the literature by BindingDB 10.1016/j.bmcl.2009.03.086 10.7270/Q2ST7N67 19433357 aid1799204 Shin, Y; Chen, W; Habel, J; Duckett, D; Ling, YY; Koenig, M; He, Y; Vojkovsky, T; LoGrasso, P; Kamenecka, TM The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=32497 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4017&target=Isoform+Alpha-1+of+Mitogen-activated+protein+kinase+10+%28Alpha-1%29+9-402%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=32497&enzyme=Isoform+Alpha-1+of+Mitogen-activated+protein+kinase+10+%28Alpha-1%29+9-402%5D&column=ki&startPg=0&Increment=50&submit=Search 44236981 85256364 ZINC62241981 1 MSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSE 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4L7F,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4X21,4Y46,4Y5H,4YR8,4Z9L,6EKD,6EMH,6EQ9,6ZR5,7KSI,7KSJ,7KSK,7ORE,7ORF,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 58362 Cc1cccc(NC(=O)c2ccc(Nc3ccccc3)o2)c1N1CCC2(CC1)OCCO2 InChI=1S/C25H27N3O4/c1-18-6-5-9-20(23(18)28-14-12-25(13-15-28)30-16-17-31-25)27-24(29)21-10-11-22(32-21)26-19-7-3-2-4-8-19/h2-11,26H,12-17H2,1H3,(H,27,29) OVXXGHJEWKPOTH-UHFFFAOYSA-N 32498 aryl piperidine, 9n Isoform Alpha-1 of Mitogen-activated protein kinase 10 (Alpha-1) 9-402] Homo sapiens >20000 Curated from the literature by BindingDB 10.1016/j.bmcl.2009.03.086 10.7270/Q2ST7N67 19433357 aid1799204 Shin, Y; Chen, W; Habel, J; Duckett, D; Ling, YY; Koenig, M; He, Y; Vojkovsky, T; LoGrasso, P; Kamenecka, TM The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=32498 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4017&target=Isoform+Alpha-1+of+Mitogen-activated+protein+kinase+10+%28Alpha-1%29+9-402%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=32498&enzyme=Isoform+Alpha-1+of+Mitogen-activated+protein+kinase+10+%28Alpha-1%29+9-402%5D&column=ki&startPg=0&Increment=50&submit=Search 44236982 85256365 ZINC62241987 1 MSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSE 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4L7F,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4X21,4Y46,4Y5H,4YR8,4Z9L,6EKD,6EMH,6EQ9,6ZR5,7KSI,7KSJ,7KSK,7ORE,7ORF,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1