BindingDB Reactant_set_id Ligand SMILES Ligand InChI Ligand InChI Key BindingDB MonomerID BindingDB Ligand Name Target Name Target Source Organism According to Curator or DataSource Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) kon (M-1-s-1) koff (s-1) pH Temp (C) Curation/DataSource Article DOI BindingDB Entry DOI PMID PubChem AID Patent Number Authors Institution Link to Ligand in BindingDB Link to Target in BindingDB Link to Ligand-Target Pair in BindingDB Ligand HET ID in PDB PDB ID(s) for Ligand-Target Complex PubChem CID of Ligand PubChem SID of Ligand ChEBI ID of Ligand ChEMBL ID of Ligand DrugBank ID of Ligand IUPHAR_GRAC ID of Ligand KEGG ID of Ligand ZINC ID of Ligand Number of Protein Chains in Target (>1 implies a multichain complex) BindingDB Target Chain Sequence PDB ID(s) of Target Chain UniProt (SwissProt) Recommended Name of Target Chain UniProt (SwissProt) Entry Name of Target Chain UniProt (SwissProt) Primary ID of Target Chain UniProt (SwissProt) Secondary ID(s) of Target Chain UniProt (SwissProt) Alternative ID(s) of Target Chain UniProt (TrEMBL) Submitted Name of Target Chain UniProt (TrEMBL) Entry Name of Target Chain UniProt (TrEMBL) Primary ID of Target Chain UniProt (TrEMBL) Secondary ID(s) of Target Chain UniProt (TrEMBL) Alternative ID(s) of Target Chain 473457 COc1ccc(OC)c(CN2CCn3nnnc3C2c2ccc(OC(C)C)cc2)c1 InChI=1S/C22H27N5O3/c1-15(2)30-18-7-5-16(6-8-18)21-22-23-24-25-27(22)12-11-26(21)14-17-13-19(28-3)9-10-20(17)29-4/h5-10,13,15,21H,11-12,14H2,1-4H3 DVBRHDZHVCRWOJ-UHFFFAOYSA-N 175804 US9688684, Compound 1: 7-(2,5-Dimethoxy-benzyl)-8-(4-isopropoxy-phenyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 24950 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175804 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175804&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169435 363892642 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473458 CC(C)Oc1ccc(cc1)C1N(Cc2ccccc2F)CCn2nnnc12 InChI=1S/C20H22FN5O/c1-14(2)27-17-9-7-15(8-10-17)19-20-22-23-24-26(20)12-11-25(19)13-16-5-3-4-6-18(16)21/h3-10,14,19H,11-13H2,1-2H3 UKBWAUKLIWTFIG-UHFFFAOYSA-N 175805 US9688684, Compound 2: 7-(2-Fluoro-benzyl)-8-(4-isopropoxy-phenyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 5445 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175805 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175805&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169410 363892643 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473459 CC(C)Oc1ccc(cc1)C1N(Cc2ccccc2F)CCn2nnnc12 InChI=1S/C20H22FN5O/c1-14(2)27-17-9-7-15(8-10-17)19-20-22-23-24-26(20)12-11-25(19)13-16-5-3-4-6-18(16)21/h3-10,14,19H,11-13H2,1-2H3 UKBWAUKLIWTFIG-UHFFFAOYSA-N 175805 US9688684, Compound 2: 7-(2-Fluoro-benzyl)-8-(4-isopropoxy-phenyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 5445 US Patent 10.7270/Q2DB7ZZK aid1794990 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175805 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175805&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169410 363892643 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473460 CC(C)Oc1ccc(cc1)C1N(CC2CCCCC2)CCn2nnnc12 InChI=1S/C20H29N5O/c1-15(2)26-18-10-8-17(9-11-18)19-20-21-22-23-25(20)13-12-24(19)14-16-6-4-3-5-7-16/h8-11,15-16,19H,3-7,12-14H2,1-2H3 AYWMWEMGFJPCDA-UHFFFAOYSA-N 175806 US9688684, Compound 3: 7-Cyclohexylmethyl-8-(4-isopropoxy-phenyl)-5,6,7,8-tetra hydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 24950 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175806 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175806&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169386 363892644 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473461 COc1ccc(cc1)C1N(Cc2ccccc2F)CCn2nnnc12 InChI=1S/C18H18FN5O/c1-25-15-8-6-13(7-9-15)17-18-20-21-22-24(18)11-10-23(17)12-14-4-2-3-5-16(14)19/h2-9,17H,10-12H2,1H3 QOTIPXDYBISRGH-UHFFFAOYSA-N 175807 US9688684, Compound 4: 7-(2-Fluoro-benzyl)-8-(4-methoxy-phenyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 24950 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175807 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175807&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169376 363892645 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473462 COc1ccc(cc1)C1N(Cc2cn(nc2C(C)C)-c2ccccc2)CCn2nnnc12 InChI=1S/C24H27N7O/c1-17(2)22-19(16-31(26-22)20-7-5-4-6-8-20)15-29-13-14-30-24(25-27-28-30)23(29)18-9-11-21(32-3)12-10-18/h4-12,16-17,23H,13-15H2,1-3H3 ABUWMCHIIJKIGR-UHFFFAOYSA-N 175808 US9688684, Compound 5: 7-(3-Isopropyl-1-phenyl-1H-pyrazol-4-ylmethyl)-8-(4-methoxy-phenyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 24950 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175808 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175808&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169534 363892646 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473463 Brc1cccc(CN2CCn3nnnc3C2c2cccc(Br)c2)c1 InChI=1S/C17H15Br2N5/c18-14-5-1-3-12(9-14)11-23-7-8-24-17(20-21-22-24)16(23)13-4-2-6-15(19)10-13/h1-6,9-10,16H,7-8,11H2 HYILJVMIKHYGMT-UHFFFAOYSA-N 175809 US9688684, Compound 6: 7-(3-Bromo-benzyl)-8-(3-bromo-phenyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 24950 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175809 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175809&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169519 363892647 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473464 Brc1cccc(c1)C1N(Cc2cccs2)CCn2nnnc12 InChI=1S/C15H14BrN5S/c16-12-4-1-3-11(9-12)14-15-17-18-19-21(15)7-6-20(14)10-13-5-2-8-22-13/h1-5,8-9,14H,6-7,10H2 HFSSXKJAIYEZPV-UHFFFAOYSA-N 175810 US9688684, Compound 7: 8-(3-Bromo-phenyl)-7-thiophen-2-ylmethyl-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 5445 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175810 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175810&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169395 363892648 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473465 Brc1cccc(c1)C1N(Cc2cccs2)CCn2nnnc12 InChI=1S/C15H14BrN5S/c16-12-4-1-3-11(9-12)14-15-17-18-19-21(15)7-6-20(14)10-13-5-2-8-22-13/h1-5,8-9,14H,6-7,10H2 HFSSXKJAIYEZPV-UHFFFAOYSA-N 175810 US9688684, Compound 7: 8-(3-Bromo-phenyl)-7-thiophen-2-ylmethyl-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 5445 US Patent 10.7270/Q2DB7ZZK aid1794990 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175810 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175810&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169395 363892648 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473466 CC(C)c1nn(cc1CN1CCn2nnnc2C1c1cccc(Br)c1)-c1ccccc1 InChI=1S/C23H24BrN7/c1-16(2)21-18(15-31(26-21)20-9-4-3-5-10-20)14-29-11-12-30-23(25-27-28-30)22(29)17-7-6-8-19(24)13-17/h3-10,13,15-16,22H,11-12,14H2,1-2H3 BLZFHOSONUFHJA-UHFFFAOYSA-N 175811 US9688684, Compound 8: 8-(3-Bromo-phenyl)-7-(3-isopropyl-1-phenyl-1H-pyrazol-4-ylmethyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 24950 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175811 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175811&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169433 363892649 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473467 Brc1cccc(c1)C1N(CC2CCCCC2)CCn2nnnc12 InChI=1S/C17H22BrN5/c18-15-8-4-7-14(11-15)16-17-19-20-21-23(17)10-9-22(16)12-13-5-2-1-3-6-13/h4,7-8,11,13,16H,1-3,5-6,9-10,12H2 BLGVPYQPXHCDDX-UHFFFAOYSA-N 175812 US9688684, Compound 9: 8-(3-Bromo-phenyl)-7-cyclohexylmethyl-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 24950 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175812 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175812&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169383 363892650 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473468 Fc1cccc(CN2CCn3nnnc3C2c2cccc(Br)c2)c1F InChI=1S/C17H14BrF2N5/c18-13-5-1-3-11(9-13)16-17-21-22-23-25(17)8-7-24(16)10-12-4-2-6-14(19)15(12)20/h1-6,9,16H,7-8,10H2 PSTCJCGXXMTWAS-UHFFFAOYSA-N 175813 US9688684, Compound 10: 8-(3-Bromo-phenyl)-7-(2,3-difluoro-benzyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 24950 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175813 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175813&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169484 363892651 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473469 CC(C)c1nn(cc1CN1CCn2[nH]nnc2C1c1ccc(F)cc1)-c1ccccc1 InChI=1S/C23H24FN7/c1-16(2)21-18(15-31(26-21)20-6-4-3-5-7-20)14-29-12-13-30-23(25-27-28-30)22(29)17-8-10-19(24)11-9-17/h3-11,15-16,22H,12-14H2,1-2H3 DTDMGQZXVKGVDF-UHFFFAOYSA-N 175814 US9688684, Compound 11: 8-(4-Fluoro-phenyl)-7-(3-isopropyl-1-phenyl-1H-pyrazol-4-ylmethyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 24950 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175814 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175814&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169486 363892652 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473470 COc1ccc(OC)c(c1)C1N(Cc2ccc(OC(C)C)cc2)CCn2nnnc12 InChI=1S/C22H27N5O3/c1-15(2)30-17-7-5-16(6-8-17)14-26-11-12-27-22(23-24-25-27)21(26)19-13-18(28-3)9-10-20(19)29-4/h5-10,13,15,21H,11-12,14H2,1-4H3 DZGXSYSDMXTAAC-UHFFFAOYSA-N 175815 US9688684, Compound 12: 8-(2,5-Dimethoxy-phenyl)-7-(4-isopropoxy-benzyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 24950 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175815 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175815&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169528 363892653 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473471 COc1ccc(OC)c(c1)C1N(Cc2cn(nc2C(C)C)-c2ccccc2)CCn2nnnc12 InChI=1S/C25H29N7O2/c1-17(2)23-18(16-32(27-23)19-8-6-5-7-9-19)15-30-12-13-31-25(26-28-29-31)24(30)21-14-20(33-3)10-11-22(21)34-4/h5-11,14,16-17,24H,12-13,15H2,1-4H3 FGTYAEITYWEICT-UHFFFAOYSA-N 175816 US9688684, Compound 13: 8-(2,5-Dimethoxy-phenyl)-7-(3-isopropyl-1-phenyl-1H-pyrazol-4-ylmethyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 24950 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175816 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175816&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169381 363892654 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473472 CN(C)c1ccc(cc1)C1N(Cc2ccccc2F)CCn2nnnc12 InChI=1S/C19H21FN6/c1-24(2)16-9-7-14(8-10-16)18-19-21-22-23-26(19)12-11-25(18)13-15-5-3-4-6-17(15)20/h3-10,18H,11-13H2,1-2H3 RGVZVZGJLPTNBS-UHFFFAOYSA-N 175817 US9688684, Compound 14: {4-[7-(2-Fluoro-benzyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazin-8-yl]-phenyl}-dimethyl-amine Nuclear receptor ROR-gamma [238-497] 5445 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175817 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175817&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169545 363892655 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473473 CN(C)c1ccc(cc1)C1N(Cc2ccccc2F)CCn2nnnc12 InChI=1S/C19H21FN6/c1-24(2)16-9-7-14(8-10-16)18-19-21-22-23-26(19)12-11-25(18)13-15-5-3-4-6-17(15)20/h3-10,18H,11-13H2,1-2H3 RGVZVZGJLPTNBS-UHFFFAOYSA-N 175817 US9688684, Compound 14: {4-[7-(2-Fluoro-benzyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazin-8-yl]-phenyl}-dimethyl-amine Nuclear receptor ROR-gamma [238-497] 500 US Patent 10.7270/Q2DB7ZZK aid1794990 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175817 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175817&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169545 363892655 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473474 CN(C)c1ccc(cc1)C1N(Cc2ccc3OCOc3c2)CCn2nnnc12 InChI=1S/C20H22N6O2/c1-24(2)16-6-4-15(5-7-16)19-20-21-22-23-26(20)10-9-25(19)12-14-3-8-17-18(11-14)28-13-27-17/h3-8,11,19H,9-10,12-13H2,1-2H3 VKCUKLSVVAIOFP-UHFFFAOYSA-N 175818 US9688684, Compound 15: [4-(7-Benzo[1,3]dioxol-5-ylmethyl-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazin-8-yl)-phenyl]-dimethyl-amine Nuclear receptor ROR-gamma [238-497] 5445 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175818 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175818&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169414 363892656 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473475 CN(C)c1ccc(cc1)C1N(Cc2ccc3OCOc3c2)CCn2nnnc12 InChI=1S/C20H22N6O2/c1-24(2)16-6-4-15(5-7-16)19-20-21-22-23-26(20)10-9-25(19)12-14-3-8-17-18(11-14)28-13-27-17/h3-8,11,19H,9-10,12-13H2,1-2H3 VKCUKLSVVAIOFP-UHFFFAOYSA-N 175818 US9688684, Compound 15: [4-(7-Benzo[1,3]dioxol-5-ylmethyl-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazin-8-yl)-phenyl]-dimethyl-amine Nuclear receptor ROR-gamma [238-497] 24950 US Patent 10.7270/Q2DB7ZZK aid1794990 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175818 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175818&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169414 363892656 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473476 CN(C)c1ccc(cc1)C1N(Cc2cc(F)ccc2F)CCn2nnnc12 InChI=1S/C19H20F2N6/c1-25(2)16-6-3-13(4-7-16)18-19-22-23-24-27(19)10-9-26(18)12-14-11-15(20)5-8-17(14)21/h3-8,11,18H,9-10,12H2,1-2H3 CAEILHRYHRTLLQ-UHFFFAOYSA-N 175819 US9688684, Compound 16: {4-[7-(2,5-Difluoro-benzyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazin-8-yl]-phenyl}-dimethyl-amine Nuclear receptor ROR-gamma [238-497] 24950 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175819 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175819&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169434 363892657 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473477 CN(C)c1ccc(cc1)C1N(Cc2cccc(F)c2)CCn2nnnc12 InChI=1S/C19H21FN6/c1-24(2)17-8-6-15(7-9-17)18-19-21-22-23-26(19)11-10-25(18)13-14-4-3-5-16(20)12-14/h3-9,12,18H,10-11,13H2,1-2H3 HKDSTIICYAUQDJ-UHFFFAOYSA-N 175820 US9688684, Compound 17: {4-[7-(3-Fluoro-benzyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazin-8-yl]-phenyl}-dimethyl-amine Nuclear receptor ROR-gamma [238-497] 500 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175820 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175820&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169448 363892658 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473478 CN(C)c1ccc(cc1)C1N(Cc2cccc(F)c2)CCn2nnnc12 InChI=1S/C19H21FN6/c1-24(2)17-8-6-15(7-9-17)18-19-21-22-23-26(19)11-10-25(18)13-14-4-3-5-16(20)12-14/h3-9,12,18H,10-11,13H2,1-2H3 HKDSTIICYAUQDJ-UHFFFAOYSA-N 175820 US9688684, Compound 17: {4-[7-(3-Fluoro-benzyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazin-8-yl]-phenyl}-dimethyl-amine Nuclear receptor ROR-gamma [238-497] 5445 US Patent 10.7270/Q2DB7ZZK aid1794990 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175820 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175820&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169448 363892658 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473479 CC(C)c1nn(cc1CN1CCn2nnnc2C1c1ccc(cc1)N(C)C)-c1ccccc1 InChI=1S/C25H30N8/c1-18(2)23-20(17-33(27-23)22-8-6-5-7-9-22)16-31-14-15-32-25(26-28-29-32)24(31)19-10-12-21(13-11-19)30(3)4/h5-13,17-18,24H,14-16H2,1-4H3 UBLDGRAQSOUUAZ-UHFFFAOYSA-N 175821 US9688684, Compound 18: {4-[7-(3-Isopropyl-1-phenyl-1H-pyrazol-4-ylmethyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazin-8-yl]-phenyl}-dimethyl-amine Nuclear receptor ROR-gamma [238-497] 24950 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175821 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175821&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169558 363892659 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473480 CN(C)c1ccc(cc1)C1N(CC2CCCCC2)CCn2nnnc12 InChI=1S/C19H28N6/c1-23(2)17-10-8-16(9-11-17)18-19-20-21-22-25(19)13-12-24(18)14-15-6-4-3-5-7-15/h8-11,15,18H,3-7,12-14H2,1-2H3 NXYHMEGHZBORQY-UHFFFAOYSA-N 175822 US9688684, Compound 19: [4-(7-Cyclohexylmethyl-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazin-8-yl)-phenyl]-dimethyl-amine Nuclear receptor ROR-gamma [238-497] 24950 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175822 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175822&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118181611 363892660 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473481 CN(C)c1ccc(cc1)C1N(Cc2cccc(F)c2F)CCn2nnnc12 InChI=1S/C19H20F2N6/c1-25(2)15-8-6-13(7-9-15)18-19-22-23-24-27(19)11-10-26(18)12-14-4-3-5-16(20)17(14)21/h3-9,18H,10-12H2,1-2H3 DWIIYVNDDQQWLI-UHFFFAOYSA-N 175823 US9688684, Compound 20: {4-[7-(2,3-Difluoro-benzyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazin-8-yl]-phenyl}-dimethyl-amine Nuclear receptor ROR-gamma [238-497] 24950 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175823 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175823&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169451 363892661 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473482 CC(C)Oc1ccc(CN2CCn3nnnc3C2c2ccccc2F)cc1 InChI=1S/C20H22FN5O/c1-14(2)27-16-9-7-15(8-10-16)13-25-11-12-26-20(22-23-24-26)19(25)17-5-3-4-6-18(17)21/h3-10,14,19H,11-13H2,1-2H3 PXYCDSJQTDNZMW-UHFFFAOYSA-N 175824 US9688684, Compound 21: 8-(2-Fluoro-phenyl)-7-(4-isopropoxy-benzyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 24950 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175824 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175824&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169437 363892662 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473483 COc1ccc(CN2CCn3nnnc3C2c2ccccc2F)cc1 InChI=1S/C18H18FN5O/c1-25-14-8-6-13(7-9-14)12-23-10-11-24-18(20-21-22-24)17(23)15-4-2-3-5-16(15)19/h2-9,17H,10-12H2,1H3 HCBWTDVGUWQDPS-UHFFFAOYSA-N 175825 US9688684, Compound 22: 8-(2-Fluoro-phenyl)-7-(4-methoxy-benzyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 24950 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175825 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175825&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169418 363892663 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473484 CN(C)c1ccc(CN2CCn3nnnc3C2c2ccccc2F)cc1 InChI=1S/C19H21FN6/c1-24(2)15-9-7-14(8-10-15)13-25-11-12-26-19(21-22-23-26)18(25)16-5-3-4-6-17(16)20/h3-10,18H,11-13H2,1-2H3 DWKCJXWGGLJBDL-UHFFFAOYSA-N 175826 US9688684, Compound 23: {4-[8-(2-Fluoro-phenyl)-5,6-dihydro-8H-tetrazolo[1,5-a]pyrazin-7-ylmethyl]-phenyl}-dimethyl-amine Nuclear receptor ROR-gamma [238-497] 24950 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175826 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175826&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169400 363892664 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473485 Fc1ccc(F)c(CN2CCn3nnnc3C2c2ccccc2F)c1 InChI=1S/C17H14F3N5/c18-12-5-6-14(19)11(9-12)10-24-7-8-25-17(21-22-23-25)16(24)13-3-1-2-4-15(13)20/h1-6,9,16H,7-8,10H2 DFGATPPFLLVSEI-UHFFFAOYSA-N 175827 US9688684, Compound 24: 7-(2,5-Difluoro-benzyl)-8-(2-fluoro-phenyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 24950 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175827 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175827&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169524 363892665 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473486 CC(C)c1nn(cc1CN1CCn2nnnc2C1c1ccccc1F)-c1ccccc1 InChI=1S/C23H24FN7/c1-16(2)21-17(15-31(26-21)18-8-4-3-5-9-18)14-29-12-13-30-23(25-27-28-30)22(29)19-10-6-7-11-20(19)24/h3-11,15-16,22H,12-14H2,1-2H3 OQUIDOIWYGAUIY-UHFFFAOYSA-N 175828 US9688684, Compound 25: 8-(2-Fluoro-phenyl)-7-(3-isopropyl-1-phenyl-1H-pyrazol-4-ylmethyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 5445 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175828 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175828&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169361 363892666 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473487 CC(C)c1nn(cc1CN1CCn2nnnc2C1c1ccccc1F)-c1ccccc1 InChI=1S/C23H24FN7/c1-16(2)21-17(15-31(26-21)18-8-4-3-5-9-18)14-29-12-13-30-23(25-27-28-30)22(29)19-10-6-7-11-20(19)24/h3-11,15-16,22H,12-14H2,1-2H3 OQUIDOIWYGAUIY-UHFFFAOYSA-N 175828 US9688684, Compound 25: 8-(2-Fluoro-phenyl)-7-(3-isopropyl-1-phenyl-1H-pyrazol-4-ylmethyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 5445 US Patent 10.7270/Q2DB7ZZK aid1794990 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175828 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175828&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169361 363892666 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473488 Fc1cccc(CN2CCn3nnnc3C2c2ccccc2F)c1F InChI=1S/C17H14F3N5/c18-13-6-2-1-5-12(13)16-17-21-22-23-25(17)9-8-24(16)10-11-4-3-7-14(19)15(11)20/h1-7,16H,8-10H2 ZSUIFRYSEANRII-UHFFFAOYSA-N 175829 US9688684, Compound 26: 7-(2,3-Difluoro-benzyl)-8-(2-fluoro-phenyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 24950 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175829 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175829&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169564 363892667 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473489 CC(C)c1nn(cc1CN1CCn2nnnc2C1c1cccc(C)c1)-c1ccccc1 InChI=1S/C24H27N7/c1-17(2)22-20(16-31(26-22)21-10-5-4-6-11-21)15-29-12-13-30-24(25-27-28-30)23(29)19-9-7-8-18(3)14-19/h4-11,14,16-17,23H,12-13,15H2,1-3H3 DMVUMJHUPQFLIY-UHFFFAOYSA-N 175830 US9688684, Compound 27: 7-(3-Isopropyl-1-phenyl-1H-pyrazol-4-ylmethyl)-8-m-tolyl-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 24950 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175830 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175830&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169567 363892668 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473490 CN(C)c1ccc(CN2CCn3nnnc3C2c2ccc3OCOc3c2)cc1 InChI=1S/C20H22N6O2/c1-24(2)16-6-3-14(4-7-16)12-25-9-10-26-20(21-22-23-26)19(25)15-5-8-17-18(11-15)28-13-27-17/h3-8,11,19H,9-10,12-13H2,1-2H3 DXWBAFICGZZGSP-UHFFFAOYSA-N 175831 US9688684, Compound 28: [4-(8-Benzo[1,3]dioxol-5-yl-5,6-dihydro-8H-tetrazolo[1,5-a]pyrazin-7-ylmethyl)-phenyl]-dimethyl-amine Nuclear receptor ROR-gamma [238-497] 24950 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175831 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175831&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169480 363892669 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473491 CC(C)c1nn(cc1CN1CCn2nnnc2C1c1ccc2OCOc2c1)-c1ccccc1 InChI=1S/C24H25N7O2/c1-16(2)22-18(14-31(26-22)19-6-4-3-5-7-19)13-29-10-11-30-24(25-27-28-30)23(29)17-8-9-20-21(12-17)33-15-32-20/h3-9,12,14,16,23H,10-11,13,15H2,1-2H3 XPCYEOGTSPZXQY-UHFFFAOYSA-N 175832 US9688684, Compound 29: 8-Benzo[1,3]dioxol-5-yl-7-(3-isopropyl-1-phenyl-1H-pyrazol-4-ylmethyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 24950 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175832 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175832&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 122639002 363892670 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473492 CN(C)c1ccc(CN2CCn3nnnc3C2c2cc(F)ccc2F)cc1 InChI=1S/C19H20F2N6/c1-25(2)15-6-3-13(4-7-15)12-26-9-10-27-19(22-23-24-27)18(26)16-11-14(20)5-8-17(16)21/h3-8,11,18H,9-10,12H2,1-2H3 ZSEBSSJRXFPUNA-UHFFFAOYSA-N 175833 US9688684, Compound 30: {4-[8-(2,5-Difluoro-phenyl)-5,6-dihydro-8H-tetrazolo[1,5-a]pyrazin-7-ylmethyl]-phenyl}-dimethyl-amine Nuclear receptor ROR-gamma [238-497] 24950 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175833 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175833&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169373 363892671 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473493 Fc1ccc(F)c(c1)C1N(Cc2ccccc2F)CCn2nnnc12 InChI=1S/C17H14F3N5/c18-12-5-6-15(20)13(9-12)16-17-21-22-23-25(17)8-7-24(16)10-11-3-1-2-4-14(11)19/h1-6,9,16H,7-8,10H2 JRTHWMIRUZKZIT-UHFFFAOYSA-N 175834 US9688684, Compound 31: 8-(2,5-Difluoro-phenyl)-7-(2-fluoro-benzyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 24950 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175834 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175834&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169455 363892672 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473494 Fc1ccc(F)c(CN2CCn3nnnc3C2c2cc(F)ccc2F)c1 InChI=1S/C17H13F4N5/c18-11-1-3-14(20)10(7-11)9-25-5-6-26-17(22-23-24-26)16(25)13-8-12(19)2-4-15(13)21/h1-4,7-8,16H,5-6,9H2 URMZZLNTCNWKIX-UHFFFAOYSA-N 175835 US9688684, Compound 32: 7-(2,5-Difluoro-benzyl)-8-(2,5-difluoro-phenyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 24950 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175835 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175835&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169363 363892673 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473495 Fc1cccc(CN2CCn3nnnc3C2c2cc(F)ccc2F)c1 InChI=1S/C17H14F3N5/c18-12-3-1-2-11(8-12)10-24-6-7-25-17(21-22-23-25)16(24)14-9-13(19)4-5-15(14)20/h1-5,8-9,16H,6-7,10H2 WWVDNKMZDRZYKM-UHFFFAOYSA-N 175836 US9688684, Compound 33: 8-(2,5-Difluoro-phenyl)-7-(3-fluoro-benzyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 5445 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175836 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175836&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169360 363892674 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473496 Fc1cccc(CN2CCn3nnnc3C2c2cc(F)ccc2F)c1 InChI=1S/C17H14F3N5/c18-12-3-1-2-11(8-12)10-24-6-7-25-17(21-22-23-25)16(24)14-9-13(19)4-5-15(14)20/h1-5,8-9,16H,6-7,10H2 WWVDNKMZDRZYKM-UHFFFAOYSA-N 175836 US9688684, Compound 33: 8-(2,5-Difluoro-phenyl)-7-(3-fluoro-benzyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 24950 US Patent 10.7270/Q2DB7ZZK aid1794990 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175836 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175836&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169360 363892674 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473497 CC(C)c1nn(cc1CN1CCn2nnnc2C1c1cc(F)ccc1F)-c1ccccc1 InChI=1S/C23H23F2N7/c1-15(2)21-16(14-32(27-21)18-6-4-3-5-7-18)13-30-10-11-31-23(26-28-29-31)22(30)19-12-17(24)8-9-20(19)25/h3-9,12,14-15,22H,10-11,13H2,1-2H3 GUJQQSVZJIIDCD-UHFFFAOYSA-N 175837 US9688684, Compound 34: 8-(2,5-Difluoro-phenyl)-7-(3-isopropyl-1-phenyl-1H-pyrazol-4-ylmethyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 500 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175837 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175837&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169523 363892675 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473498 CC(C)c1nn(cc1CN1CCn2nnnc2C1c1cc(F)ccc1F)-c1ccccc1 InChI=1S/C23H23F2N7/c1-15(2)21-16(14-32(27-21)18-6-4-3-5-7-18)13-30-10-11-31-23(26-28-29-31)22(30)19-12-17(24)8-9-20(19)25/h3-9,12,14-15,22H,10-11,13H2,1-2H3 GUJQQSVZJIIDCD-UHFFFAOYSA-N 175837 US9688684, Compound 34: 8-(2,5-Difluoro-phenyl)-7-(3-isopropyl-1-phenyl-1H-pyrazol-4-ylmethyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 5445 US Patent 10.7270/Q2DB7ZZK aid1794990 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175837 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175837&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169523 363892675 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473499 Fc1ccc(F)c(c1)C1N(Cc2cccc(F)c2F)CCn2nnnc12 InChI=1S/C17H13F4N5/c18-11-4-5-13(19)12(8-11)16-17-22-23-24-26(17)7-6-25(16)9-10-2-1-3-14(20)15(10)21/h1-5,8,16H,6-7,9H2 XFDZRNGPTNTUAD-UHFFFAOYSA-N 175838 US9688684, Compound 35: 7-(2,3-Difluoro-benzyl)-8-(2,5-difluoro-phenyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 24950 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175838 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175838&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169459 363892676 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473500 CN(C)c1ccc(CN2CCn3nnnc3C2c2cccc(F)c2)cc1 InChI=1S/C19H21FN6/c1-24(2)17-8-6-14(7-9-17)13-25-10-11-26-19(21-22-23-26)18(25)15-4-3-5-16(20)12-15/h3-9,12,18H,10-11,13H2,1-2H3 OIBZQQZVAZZACC-UHFFFAOYSA-N 175839 US9688684, Compound 36: {4-[8-(3-Fluoro-phenyl)-5,6-dihydro-8H-tetrazolo[1,5-a]pyrazin-7-ylmethyl]-phenyl}-dimethyl-amine Nuclear receptor ROR-gamma [238-497] 24950 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175839 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175839&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169421 363892677 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473501 Fc1cccc(c1)C1N(Cc2cc(F)ccc2F)CCn2nnnc12 InChI=1S/C17H14F3N5/c18-13-3-1-2-11(8-13)16-17-21-22-23-25(17)7-6-24(16)10-12-9-14(19)4-5-15(12)20/h1-5,8-9,16H,6-7,10H2 AVEMSAPCCIVACI-UHFFFAOYSA-N 175840 US9688684, Compound 37: 7-(2,5-Difluoro-benzyl)-8-(3-fluoro-phenyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 24950 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175840 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175840&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169490 363892678 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473502 Fc1cccc(CN2CCn3nnnc3C2c2cccc(F)c2)c1 InChI=1S/C17H15F2N5/c18-14-5-1-3-12(9-14)11-23-7-8-24-17(20-21-22-24)16(23)13-4-2-6-15(19)10-13/h1-6,9-10,16H,7-8,11H2 QSKOEIGHYVNWEP-UHFFFAOYSA-N 175841 US9688684, Compound 38: 7-(3-Fluoro-benzyl)-8-(3-fluoro-phenyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 5445 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175841 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175841&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169495 363892679 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473503 Fc1cccc(CN2CCn3nnnc3C2c2cccc(F)c2)c1 InChI=1S/C17H15F2N5/c18-14-5-1-3-12(9-14)11-23-7-8-24-17(20-21-22-24)16(23)13-4-2-6-15(19)10-13/h1-6,9-10,16H,7-8,11H2 QSKOEIGHYVNWEP-UHFFFAOYSA-N 175841 US9688684, Compound 38: 7-(3-Fluoro-benzyl)-8-(3-fluoro-phenyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 5445 US Patent 10.7270/Q2DB7ZZK aid1794990 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175841 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175841&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169495 363892679 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473504 Fc1cccc(c1)C1N(Cc2ccc(Cl)cc2)CCn2nnnc12 InChI=1S/C17H15ClFN5/c18-14-6-4-12(5-7-14)11-23-8-9-24-17(20-21-22-24)16(23)13-2-1-3-15(19)10-13/h1-7,10,16H,8-9,11H2 JDNVFIRGQWCWOF-UHFFFAOYSA-N 175842 US9688684, Compound 39: 7-(4-Chloro-benzyl)-8-(3-fluoro-phenyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 24950 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175842 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175842&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169526 363892680 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473505 CC(C)c1nn(cc1CN1CCn2nnnc2C1c1cccc(F)c1)-c1ccccc1 InChI=1S/C23H24FN7/c1-16(2)21-18(15-31(26-21)20-9-4-3-5-10-20)14-29-11-12-30-23(25-27-28-30)22(29)17-7-6-8-19(24)13-17/h3-10,13,15-16,22H,11-12,14H2,1-2H3 YNGVUJRHNOANHW-UHFFFAOYSA-N 175843 US9688684, Compound 40: 8-(3-Fluoro-phenyl)-7-(3-isopropyl-1-phenyl-1H-pyrazol-4-ylmethyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 24950 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175843 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175843&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169542 363892681 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473506 Fc1cccc(c1)C1N(Cc2cccc(F)c2F)CCn2nnnc12 InChI=1S/C17H14F3N5/c18-13-5-1-3-11(9-13)16-17-21-22-23-25(17)8-7-24(16)10-12-4-2-6-14(19)15(12)20/h1-6,9,16H,7-8,10H2 OKEQSUOTGHJSMZ-UHFFFAOYSA-N 175844 US9688684, Compound 41: 7-(2,3-Difluoro-benzyl)-8-(3-fluoro-phenyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 24950 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175844 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175844&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169449 363892682 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473507 Fc1cccc(CN2CCn3nnnc3C2c2ccc(Cl)cc2)c1 InChI=1S/C17H15ClFN5/c18-14-6-4-13(5-7-14)16-17-20-21-22-24(17)9-8-23(16)11-12-2-1-3-15(19)10-12/h1-7,10,16H,8-9,11H2 MHOSSWWZFRUNTR-UHFFFAOYSA-N 175845 US9688684, Compound 42: 8-(4-Chloro-phenyl)-7-(3-fluoro-benzyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 500 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175845 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175845&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169487 363892683 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473508 Fc1cccc(CN2CCn3nnnc3C2c2ccc(Cl)cc2)c1 InChI=1S/C17H15ClFN5/c18-14-6-4-13(5-7-14)16-17-20-21-22-24(17)9-8-23(16)11-12-2-1-3-15(19)10-12/h1-7,10,16H,8-9,11H2 MHOSSWWZFRUNTR-UHFFFAOYSA-N 175845 US9688684, Compound 42: 8-(4-Chloro-phenyl)-7-(3-fluoro-benzyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 24950 US Patent 10.7270/Q2DB7ZZK aid1794990 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175845 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175845&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169487 363892683 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473509 CCOc1ccc(cc1)C1N(Cc2cn(nc2C(C)C)-c2ccccc2)CCn2nnnc12 InChI=1S/C25H29N7O/c1-4-33-22-12-10-19(11-13-22)24-25-26-28-29-31(25)15-14-30(24)16-20-17-32(27-23(20)18(2)3)21-8-6-5-7-9-21/h5-13,17-18,24H,4,14-16H2,1-3H3 CWUUAAWSDGSMOM-UHFFFAOYSA-N 175846 US9688684, Compound 43: 8-(4-Ethoxy-phenyl)-7-(3-isopropyl-1-phenyl-1H-pyrazol-4-ylmethyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 24950 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175846 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175846&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169384 363892684 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473510 CCOc1ccc(cc1)C1N(CC2CCCCC2)CCn2nnnc12 InChI=1S/C19H27N5O/c1-2-25-17-10-8-16(9-11-17)18-19-20-21-22-24(19)13-12-23(18)14-15-6-4-3-5-7-15/h8-11,15,18H,2-7,12-14H2,1H3 UVXUFBYGMYMOLH-UHFFFAOYSA-N 175847 US9688684, Compound 44: 7-Cyclohexylmethyl-8-(4-ethoxy-phenyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 24950 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175847 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175847&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169391 363892685 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473511 CCOc1ccc(cc1)C1N(Cc2cccc(F)c2F)CCn2nnnc12 InChI=1S/C19H19F2N5O/c1-2-27-15-8-6-13(7-9-15)18-19-22-23-24-26(19)11-10-25(18)12-14-4-3-5-16(20)17(14)21/h3-9,18H,2,10-12H2,1H3 LGOOEHMUXNWRDM-UHFFFAOYSA-N 175848 US9688684, Compound 45: 7-(2,3-Difluoro-benzyl)-8-(4-ethoxy-phenyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 24950 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175848 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175848&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169543 363892686 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473512 Brc1ccc(CN2CCn3nnnc3C2c2cccs2)cc1 InChI=1S/C15H14BrN5S/c16-12-5-3-11(4-6-12)10-20-7-8-21-15(17-18-19-21)14(20)13-2-1-9-22-13/h1-6,9,14H,7-8,10H2 WKVQZKRMQLKOCE-UHFFFAOYSA-N 175849 US9688684, Compound 46: 7-(4-Bromo-benzyl)-8-thiophen-2-yl-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 24950 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175849 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175849&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169475 363892687 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473513 C(N1CCn2nnnc2C1c1cccs1)c1cccs1 InChI=1S/C13H13N5S2/c1-3-10(19-7-1)9-17-5-6-18-13(14-15-16-18)12(17)11-4-2-8-20-11/h1-4,7-8,12H,5-6,9H2 ZJIPVMRQJXKWKL-UHFFFAOYSA-N 175850 US9688684, Compound 47: 8-Thiophen-2-yl-7-thiophen-2-ylmethyl-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 24950 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175850 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175850&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169362 363892688 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473514 CC(C)c1nn(cc1CN1CCn2nnnc2C1c1cccs1)-c1ccccc1 InChI=1S/C21H23N7S/c1-15(2)19-16(14-28(23-19)17-7-4-3-5-8-17)13-26-10-11-27-21(22-24-25-27)20(26)18-9-6-12-29-18/h3-9,12,14-15,20H,10-11,13H2,1-2H3 OLTPRXHFZKEUIX-UHFFFAOYSA-N 175851 US9688684, Compound 48: 7-(3-Isopropyl-1-phenyl-1H-pyrazol-4-ylmethyl)-8-thiophen-2-yl-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 500 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175851 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175851&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169563 363892689 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473515 CC(C)c1nn(cc1CN1CCn2nnnc2C1c1cccs1)-c1ccccc1 InChI=1S/C21H23N7S/c1-15(2)19-16(14-28(23-19)17-7-4-3-5-8-17)13-26-10-11-27-21(22-24-25-27)20(26)18-9-6-12-29-18/h3-9,12,14-15,20H,10-11,13H2,1-2H3 OLTPRXHFZKEUIX-UHFFFAOYSA-N 175851 US9688684, Compound 48: 7-(3-Isopropyl-1-phenyl-1H-pyrazol-4-ylmethyl)-8-thiophen-2-yl-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 24950 US Patent 10.7270/Q2DB7ZZK aid1794990 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175851 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175851&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169563 363892689 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473516 C(C1CCCCC1)N1CCn2nnnc2C1c1cccs1 InChI=1S/C15H21N5S/c1-2-5-12(6-3-1)11-19-8-9-20-15(16-17-18-20)14(19)13-7-4-10-21-13/h4,7,10,12,14H,1-3,5-6,8-9,11H2 KOEXANMCQRHNQE-UHFFFAOYSA-N 175852 US9688684, Compound 49: 7-Cyclohexylmethyl-8-thiophen-2-yl-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 24950 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175852 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175852&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169463 363892690 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473517 Fc1cccc(CN2CCn3nnnc3C2c2cccs2)c1F InChI=1S/C15H13F2N5S/c16-11-4-1-3-10(13(11)17)9-21-6-7-22-15(18-19-20-22)14(21)12-5-2-8-23-12/h1-5,8,14H,6-7,9H2 HIXRJJDBDZUWKH-UHFFFAOYSA-N 175853 US9688684, Compound 50: 7-(2,3-Difluoro-benzyl)-8-thiophen-2-yl-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 24950 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175853 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175853&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169532 363892691 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473518 COc1ccc(CN2CCn3nnnc3C2c2cn(nc2C(C)C)-c2ccccc2)cc1 InChI=1S/C24H27N7O/c1-17(2)22-21(16-31(26-22)19-7-5-4-6-8-19)23-24-25-27-28-30(24)14-13-29(23)15-18-9-11-20(32-3)12-10-18/h4-12,16-17,23H,13-15H2,1-3H3 ZKTRYBQLQOQHDF-UHFFFAOYSA-N 175854 US9688684, Compound 51: 8-(3-Isopropyl-1-phenyl-1H-pyrazol-4-yl)-7-(4-methoxy-benzyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 24950 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175854 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175854&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169469 363892692 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473519 COc1ccc(CN2CCn3nnnc3C2c2cn(nc2C(C)C)-c2ccccc2)cc1 InChI=1S/C24H27N7O/c1-17(2)22-21(16-31(26-22)19-7-5-4-6-8-19)23-24-25-27-28-30(24)14-13-29(23)15-18-9-11-20(32-3)12-10-18/h4-12,16-17,23H,13-15H2,1-3H3 ZKTRYBQLQOQHDF-UHFFFAOYSA-N 175854 US9688684, Compound 51: 8-(3-Isopropyl-1-phenyl-1H-pyrazol-4-yl)-7-(4-methoxy-benzyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 24950 US Patent 10.7270/Q2DB7ZZK aid1794990 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175854 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175854&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169469 363892692 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473520 CC(C)c1nn(cc1C1N(Cc2ccc(Br)cc2)CCn2nnnc12)-c1ccccc1 InChI=1S/C23H24BrN7/c1-16(2)21-20(15-31(26-21)19-6-4-3-5-7-19)22-23-25-27-28-30(23)13-12-29(22)14-17-8-10-18(24)11-9-17/h3-11,15-16,22H,12-14H2,1-2H3 KGWGSXKLKUPZEM-UHFFFAOYSA-N 175855 US9688684, Compound 52: 7-(4-Bromo-benzyl)-8-(3-isopropyl-1-phenyl-1H-pyrazol-4-yl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 500 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175855 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175855&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169359 363892693 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473521 CC(C)c1nn(cc1C1N(Cc2ccc(Br)cc2)CCn2nnnc12)-c1ccccc1 InChI=1S/C23H24BrN7/c1-16(2)21-20(15-31(26-21)19-6-4-3-5-7-19)22-23-25-27-28-30(23)13-12-29(22)14-17-8-10-18(24)11-9-17/h3-11,15-16,22H,12-14H2,1-2H3 KGWGSXKLKUPZEM-UHFFFAOYSA-N 175855 US9688684, Compound 52: 7-(4-Bromo-benzyl)-8-(3-isopropyl-1-phenyl-1H-pyrazol-4-yl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 5445 US Patent 10.7270/Q2DB7ZZK aid1794990 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175855 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175855&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169359 363892693 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473522 CC(C)c1nn(cc1C1N(Cc2ccc(F)cc2)CCn2nnnc12)-c1ccccc1 InChI=1S/C23H24FN7/c1-16(2)21-20(15-31(26-21)19-6-4-3-5-7-19)22-23-25-27-28-30(23)13-12-29(22)14-17-8-10-18(24)11-9-17/h3-11,15-16,22H,12-14H2,1-2H3 IRTSNVNQHRFSIF-UHFFFAOYSA-N 175856 US9688684, Compound 53: 7-(4-Fluoro-benzyl)-8-(3-isopropyl-1-phenyl-1H-pyrazol-4-yl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 24950 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175856 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175856&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169443 363892694 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473523 COc1ccc(OC)c(CN2CCn3nnnc3C2c2cn(nc2C(C)C)-c2ccccc2)c1 InChI=1S/C25H29N7O2/c1-17(2)23-21(16-32(27-23)19-8-6-5-7-9-19)24-25-26-28-29-31(25)13-12-30(24)15-18-14-20(33-3)10-11-22(18)34-4/h5-11,14,16-17,24H,12-13,15H2,1-4H3 BXXQTQOYSDIEOT-UHFFFAOYSA-N 175857 US9688684, Compound 54: 7-(2,5-Dimethoxy-benzyl)-8-(3-isopropyl-1-phenyl-1H-pyrazol-4-yl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 24950 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175857 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175857&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169392 363892695 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473524 COc1ccc(OC)c(CN2CCn3nnnc3C2c2cn(nc2C(C)C)-c2ccccc2)c1 InChI=1S/C25H29N7O2/c1-17(2)23-21(16-32(27-23)19-8-6-5-7-9-19)24-25-26-28-29-31(25)13-12-30(24)15-18-14-20(33-3)10-11-22(18)34-4/h5-11,14,16-17,24H,12-13,15H2,1-4H3 BXXQTQOYSDIEOT-UHFFFAOYSA-N 175857 US9688684, Compound 54: 7-(2,5-Dimethoxy-benzyl)-8-(3-isopropyl-1-phenyl-1H-pyrazol-4-yl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 24950 US Patent 10.7270/Q2DB7ZZK aid1794990 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175857 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175857&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169392 363892695 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473525 CC(C)c1nn(cc1C1N(Cc2ccc(cc2)N(C)C)CCn2nnnc12)-c1ccccc1 InChI=1S/C25H30N8/c1-18(2)23-22(17-33(27-23)21-8-6-5-7-9-21)24-25-26-28-29-32(25)15-14-31(24)16-19-10-12-20(13-11-19)30(3)4/h5-13,17-18,24H,14-16H2,1-4H3 DWETVYOJBZDEPB-UHFFFAOYSA-N 175858 US9688684, Compound 55: {4-[8-(3-Isopropyl-1-phenyl-1H-pyrazol-4-yl)-5,6-dihydro-8H-tetrazolo[1,5-a]pyrazin-7-ylmethyl]-phenyl}-dimethyl-amine Nuclear receptor ROR-gamma [238-497] 5445 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175858 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175858&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169555 363892696 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473526 CC(C)c1nn(cc1C1N(Cc2ccc(cc2)N(C)C)CCn2nnnc12)-c1ccccc1 InChI=1S/C25H30N8/c1-18(2)23-22(17-33(27-23)21-8-6-5-7-9-21)24-25-26-28-29-32(25)15-14-31(24)16-19-10-12-20(13-11-19)30(3)4/h5-13,17-18,24H,14-16H2,1-4H3 DWETVYOJBZDEPB-UHFFFAOYSA-N 175858 US9688684, Compound 55: {4-[8-(3-Isopropyl-1-phenyl-1H-pyrazol-4-yl)-5,6-dihydro-8H-tetrazolo[1,5-a]pyrazin-7-ylmethyl]-phenyl}-dimethyl-amine Nuclear receptor ROR-gamma [238-497] 5445 US Patent 10.7270/Q2DB7ZZK aid1794990 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175858 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175858&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169555 363892696 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473527 CC(C)c1nn(cc1C1N(Cc2ccccc2F)CCn2nnnc12)-c1ccccc1 InChI=1S/C23H24FN7/c1-16(2)21-19(15-31(26-21)18-9-4-3-5-10-18)22-23-25-27-28-30(23)13-12-29(22)14-17-8-6-7-11-20(17)24/h3-11,15-16,22H,12-14H2,1-2H3 UYAOKKVBOYBCJG-UHFFFAOYSA-N 175859 US9688684, Compound 56: 7-(2-Fluoro-benzyl)-8-(3-isopropyl-1-phenyl-1H-pyrazol-4-yl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 24950 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175859 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175859&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169416 363892697 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473528 CC(C)c1nn(cc1C1N(Cc2cccc(C)c2)CCn2nnnc12)-c1ccccc1 InChI=1S/C24H27N7/c1-17(2)22-21(16-31(26-22)20-10-5-4-6-11-20)23-24-25-27-28-30(24)13-12-29(23)15-19-9-7-8-18(3)14-19/h4-11,14,16-17,23H,12-13,15H2,1-3H3 RLRGXDFYZGFYNE-UHFFFAOYSA-N 175860 US9688684, Compound 57: 8-(3-Isopropyl-1-phenyl-1H-pyrazol-4-yl)-7-(3-methyl-benzyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 24950 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175860 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175860&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169464 363892698 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473529 CC(C)c1nn(cc1C1N(Cc2ccc3OCOc3c2)CCn2nnnc12)-c1ccccc1 InChI=1S/C24H25N7O2/c1-16(2)22-19(14-31(26-22)18-6-4-3-5-7-18)23-24-25-27-28-30(24)11-10-29(23)13-17-8-9-20-21(12-17)33-15-32-20/h3-9,12,14,16,23H,10-11,13,15H2,1-2H3 OMMCZKNZOJRUBN-UHFFFAOYSA-N 175861 US9688684, Compound 58: 7-Benzo[1,3]dioxol-5-ylmethyl-8-(3-isopropyl-1-phenyl-1H-pyrazol-4-yl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 24950 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175861 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175861&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169377 363892699 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473530 CC(C)c1nn(cc1C1N(Cc2ccc3OCOc3c2)CCn2nnnc12)-c1ccccc1 InChI=1S/C24H25N7O2/c1-16(2)22-19(14-31(26-22)18-6-4-3-5-7-18)23-24-25-27-28-30(24)11-10-29(23)13-17-8-9-20-21(12-17)33-15-32-20/h3-9,12,14,16,23H,10-11,13,15H2,1-2H3 OMMCZKNZOJRUBN-UHFFFAOYSA-N 175861 US9688684, Compound 58: 7-Benzo[1,3]dioxol-5-ylmethyl-8-(3-isopropyl-1-phenyl-1H-pyrazol-4-yl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 5445 US Patent 10.7270/Q2DB7ZZK aid1794990 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175861 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175861&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169377 363892699 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473531 CC(C)c1nn(cc1C1N(Cc2cc(F)ccc2F)CCn2nnnc12)-c1ccccc1 InChI=1S/C23H23F2N7/c1-15(2)21-19(14-32(27-21)18-6-4-3-5-7-18)22-23-26-28-29-31(23)11-10-30(22)13-16-12-17(24)8-9-20(16)25/h3-9,12,14-15,22H,10-11,13H2,1-2H3 UDHUGXAVFSIAHH-UHFFFAOYSA-N 175862 US9688684, Compound 59: 7-(2,5-Difluoro-benzyl)-8-(3-isopropyl-1-phenyl-1H-pyrazol-4-yl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 24950 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175862 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175862&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169438 363892700 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473532 CCOc1ccc(CN2CCn3nnnc3C2c2cn(nc2C(C)C)-c2ccccc2)cc1 InChI=1S/C25H29N7O/c1-4-33-21-12-10-19(11-13-21)16-30-14-15-31-25(26-28-29-31)24(30)22-17-32(27-23(22)18(2)3)20-8-6-5-7-9-20/h5-13,17-18,24H,4,14-16H2,1-3H3 ZFRGMPIYWJVILV-UHFFFAOYSA-N 175863 US9688684, Compound 60: 7-(4-Ethoxy-benzyl)-8-(3-isopropyl-1-phenyl-1H-pyrazol-4-yl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 24950 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175863 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175863&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169368 363892701 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473533 CC(C)c1nn(cc1C1N(Cc2cccs2)CCn2nnnc12)-c1ccccc1 InChI=1S/C21H23N7S/c1-15(2)19-18(14-28(23-19)16-7-4-3-5-8-16)20-21-22-24-25-27(21)11-10-26(20)13-17-9-6-12-29-17/h3-9,12,14-15,20H,10-11,13H2,1-2H3 HKLDLNMOGCKFDN-UHFFFAOYSA-N 175864 US9688684, Compound 61: 8-(3-Isopropyl-1-phenyl-1H-pyrazol-4-yl)-7-thiophen-2-ylmethyl-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 500 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175864 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175864&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169553 363892702 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473534 CC(C)c1nn(cc1C1N(Cc2cccs2)CCn2nnnc12)-c1ccccc1 InChI=1S/C21H23N7S/c1-15(2)19-18(14-28(23-19)16-7-4-3-5-8-16)20-21-22-24-25-27(21)11-10-26(20)13-17-9-6-12-29-17/h3-9,12,14-15,20H,10-11,13H2,1-2H3 HKLDLNMOGCKFDN-UHFFFAOYSA-N 175864 US9688684, Compound 61: 8-(3-Isopropyl-1-phenyl-1H-pyrazol-4-yl)-7-thiophen-2-ylmethyl-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 500 US Patent 10.7270/Q2DB7ZZK aid1794990 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175864 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175864&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169553 363892702 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473535 CC(C)c1nn(cc1C1N(Cc2cccs2)CCn2nnnc12)-c1ccccc1 InChI=1S/C21H23N7S/c1-15(2)19-18(14-28(23-19)16-7-4-3-5-8-16)20-21-22-24-25-27(21)11-10-26(20)13-17-9-6-12-29-17/h3-9,12,14-15,20H,10-11,13H2,1-2H3 HKLDLNMOGCKFDN-UHFFFAOYSA-N 175864 US9688684, Compound 61: 8-(3-Isopropyl-1-phenyl-1H-pyrazol-4-yl)-7-thiophen-2-ylmethyl-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 500 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175864 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175864&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169553 363892702 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473536 CC(C)c1nn(cc1C1N(Cc2cccs2)CCn2nnnc12)-c1ccccc1 InChI=1S/C21H23N7S/c1-15(2)19-18(14-28(23-19)16-7-4-3-5-8-16)20-21-22-24-25-27(21)11-10-26(20)13-17-9-6-12-29-17/h3-9,12,14-15,20H,10-11,13H2,1-2H3 HKLDLNMOGCKFDN-UHFFFAOYSA-N 175864 US9688684, Compound 61: 8-(3-Isopropyl-1-phenyl-1H-pyrazol-4-yl)-7-thiophen-2-ylmethyl-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 500 US Patent 10.7270/Q2DB7ZZK aid1794990 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175864 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175864&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169553 363892702 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473537 CC(C)c1nn(cc1C1N(Cc2cccs2)CCn2nnnc12)-c1ccccc1 InChI=1S/C21H23N7S/c1-15(2)19-18(14-28(23-19)16-7-4-3-5-8-16)20-21-22-24-25-27(21)11-10-26(20)13-17-9-6-12-29-17/h3-9,12,14-15,20H,10-11,13H2,1-2H3 HKLDLNMOGCKFDN-UHFFFAOYSA-N 175864 US9688684, Compound 61: 8-(3-Isopropyl-1-phenyl-1H-pyrazol-4-yl)-7-thiophen-2-ylmethyl-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 24950 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175864 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175864&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169553 363892702 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473538 CC(C)c1nn(cc1C1N(Cc2cccs2)CCn2nnnc12)-c1ccccc1 InChI=1S/C21H23N7S/c1-15(2)19-18(14-28(23-19)16-7-4-3-5-8-16)20-21-22-24-25-27(21)11-10-26(20)13-17-9-6-12-29-17/h3-9,12,14-15,20H,10-11,13H2,1-2H3 HKLDLNMOGCKFDN-UHFFFAOYSA-N 175864 US9688684, Compound 61: 8-(3-Isopropyl-1-phenyl-1H-pyrazol-4-yl)-7-thiophen-2-ylmethyl-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 5445 US Patent 10.7270/Q2DB7ZZK aid1794990 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175864 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175864&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169553 363892702 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473539 CC(C)c1nn(cc1CN1CCn2nnnc2C1c1cn(nc1C(C)C)-c1ccccc1)-c1ccccc1 InChI=1S/C29H33N9/c1-20(2)26-22(18-37(31-26)23-11-7-5-8-12-23)17-35-15-16-36-29(30-33-34-36)28(35)25-19-38(32-27(25)21(3)4)24-13-9-6-10-14-24/h5-14,18-21,28H,15-17H2,1-4H3 SBZXQEWYDMUKRV-UHFFFAOYSA-N 175865 US9688684, Compound 62: 8-(3-Isopropyl-1-phenyl-1H-pyrazol-4-yl)-7-(3-isopropyl-1-phenyl-1H-pyrazol-4-ylmethyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 24950 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175865 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175865&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169548 363892703 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473540 CC(C)c1nn(cc1C1N(Cc2cccc(F)c2F)CCn2nnnc12)-c1ccccc1 InChI=1S/C23H23F2N7/c1-15(2)21-18(14-32(27-21)17-8-4-3-5-9-17)22-23-26-28-29-31(23)12-11-30(22)13-16-7-6-10-19(24)20(16)25/h3-10,14-15,22H,11-13H2,1-2H3 UQVYSUYJAWIKHY-UHFFFAOYSA-N 175866 US9688684, Compound 63: 7-(2,3-Difluoro-benzyl)-8-(3-isopropyl-1-phenyl-1H-pyrazol-4-yl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 24950 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175866 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175866&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169502 363892704 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473541 CC(C)c1nn(cc1C1N(Cc2cccc(F)c2F)CCn2nnnc12)-c1ccccc1 InChI=1S/C23H23F2N7/c1-15(2)21-18(14-32(27-21)17-8-4-3-5-9-17)22-23-26-28-29-31(23)12-11-30(22)13-16-7-6-10-19(24)20(16)25/h3-10,14-15,22H,11-13H2,1-2H3 UQVYSUYJAWIKHY-UHFFFAOYSA-N 175866 US9688684, Compound 63: 7-(2,3-Difluoro-benzyl)-8-(3-isopropyl-1-phenyl-1H-pyrazol-4-yl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 500 US Patent 10.7270/Q2DB7ZZK aid1794990 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175866 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175866&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169502 363892704 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473542 CC(C)Oc1ccc(CN2CCn3nnnc3C2C2CCCCC2)cc1 InChI=1S/C20H29N5O/c1-15(2)26-18-10-8-16(9-11-18)14-24-12-13-25-20(21-22-23-25)19(24)17-6-4-3-5-7-17/h8-11,15,17,19H,3-7,12-14H2,1-2H3 MTFDJAHVYUZWGI-UHFFFAOYSA-N 175867 US9688684, Compound 64: 8-Cyclohexyl-7-(4-isopropoxy-benzyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 24950 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175867 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175867&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118181609 363892705 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473543 Brc1cccc(CN2CCn3nnnc3C2C2CCCCC2)c1 InChI=1S/C17H22BrN5/c18-15-8-4-5-13(11-15)12-22-9-10-23-17(19-20-21-23)16(22)14-6-2-1-3-7-14/h4-5,8,11,14,16H,1-3,6-7,9-10,12H2 ONZGRQDBNNYNEV-UHFFFAOYSA-N 175868 US9688684, Compound 65: 7-(3-Bromo-benzyl)-8-cyclohexyl-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 24950 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175868 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175868&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 122638994 363892706 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473544 Brc1cccc(CN2CCn3nnnc3C2C2CCCCC2)c1 InChI=1S/C17H22BrN5/c18-15-8-4-5-13(11-15)12-22-9-10-23-17(19-20-21-23)16(22)14-6-2-1-3-7-14/h4-5,8,11,14,16H,1-3,6-7,9-10,12H2 ONZGRQDBNNYNEV-UHFFFAOYSA-N 175868 US9688684, Compound 65: 7-(3-Bromo-benzyl)-8-cyclohexyl-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 24950 US Patent 10.7270/Q2DB7ZZK aid1794990 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175868 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175868&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 122638994 363892706 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473545 CN(C)c1ccc(CN2CCn3nnnc3C2C2CCCCC2)cc1 InChI=1S/C19H28N6/c1-23(2)17-10-8-15(9-11-17)14-24-12-13-25-19(20-21-22-25)18(24)16-6-4-3-5-7-16/h8-11,16,18H,3-7,12-14H2,1-2H3 VSBFYEQTVMSGQX-UHFFFAOYSA-N 175869 US9688684, Compound 66: [4-(8-Cyclohexyl-5,6-dihydro-8H-tetrazolo[1,5-a]pyrazin-7-ylmethyl)-phenyl]-dimethyl-amine Nuclear receptor ROR-gamma [238-497] 24950 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175869 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175869&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169389 363892707 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473546 CCOc1ccc(CN2CCn3nnnc3C2C2CCCCC2)cc1 InChI=1S/C19H27N5O/c1-2-25-17-10-8-15(9-11-17)14-23-12-13-24-19(20-21-22-24)18(23)16-6-4-3-5-7-16/h8-11,16,18H,2-7,12-14H2,1H3 UDMJQCBAIORJKI-UHFFFAOYSA-N 175870 US9688684, Compound 67: 8-Cyclohexyl-7-(4-ethoxy-benzyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 24950 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175870 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175870&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169420 363892708 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473547 C(N1CCn2nnnc2C1C1CCCCC1)c1cccs1 InChI=1S/C15H21N5S/c1-2-5-12(6-3-1)14-15-16-17-18-20(15)9-8-19(14)11-13-7-4-10-21-13/h4,7,10,12,14H,1-3,5-6,8-9,11H2 VZAOUYARPDCHMJ-UHFFFAOYSA-N 175871 US9688684, Compound 68: 8-Cyclohexyl-7-thiophen-2-ylmethyl-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 5445 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175871 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175871&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169460 363892709 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473548 C(N1CCn2nnnc2C1C1CCCCC1)c1cccs1 InChI=1S/C15H21N5S/c1-2-5-12(6-3-1)14-15-16-17-18-20(15)9-8-19(14)11-13-7-4-10-21-13/h4,7,10,12,14H,1-3,5-6,8-9,11H2 VZAOUYARPDCHMJ-UHFFFAOYSA-N 175871 US9688684, Compound 68: 8-Cyclohexyl-7-thiophen-2-ylmethyl-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 24950 US Patent 10.7270/Q2DB7ZZK aid1794990 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175871 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175871&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169460 363892709 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473549 C(C1CCCCC1)N1CCn2nnnc2C1C1CCCCC1 InChI=1S/C17H29N5/c1-3-7-14(8-4-1)13-21-11-12-22-17(18-19-20-22)16(21)15-9-5-2-6-10-15/h14-16H,1-13H2 CNCSOCOIZKEOPH-UHFFFAOYSA-N 175872 US9688684, Compound 69: 8-Cyclohexyl-7-cyclohexylmethyl-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 24950 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175872 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175872&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169407 363892710 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473550 Fc1cccc(C2N(Cc3cccc(Br)c3)CCn3nnnc23)c1F InChI=1S/C17H14BrF2N5/c18-12-4-1-3-11(9-12)10-24-7-8-25-17(21-22-23-25)16(24)13-5-2-6-14(19)15(13)20/h1-6,9,16H,7-8,10H2 YVMWVDRYSGUZLC-UHFFFAOYSA-N 175873 US9688684, Compound 70: 7-(3-Bromo-benzyl)-8-(2,3-difluoro-phenyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 5445 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175873 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175873&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169444 363892711 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473551 Fc1cccc(C2N(Cc3cccc(Br)c3)CCn3nnnc23)c1F InChI=1S/C17H14BrF2N5/c18-12-4-1-3-11(9-12)10-24-7-8-25-17(21-22-23-25)16(24)13-5-2-6-14(19)15(13)20/h1-6,9,16H,7-8,10H2 YVMWVDRYSGUZLC-UHFFFAOYSA-N 175873 US9688684, Compound 70: 7-(3-Bromo-benzyl)-8-(2,3-difluoro-phenyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 5445 US Patent 10.7270/Q2DB7ZZK aid1794990 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175873 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175873&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169444 363892711 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473552 COc1ccc(OC)c(CN2CCn3nnnc3C2c2cccc(F)c2F)c1 InChI=1S/C19H19F2N5O2/c1-27-13-6-7-16(28-2)12(10-13)11-25-8-9-26-19(22-23-24-26)18(25)14-4-3-5-15(20)17(14)21/h3-7,10,18H,8-9,11H2,1-2H3 LRLWMWLVTGJVFW-UHFFFAOYSA-N 175874 US9688684, Compound 71: 8-(2,3-Difluoro-phenyl)-7-(2,5-dimethoxy-benzyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 24950 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175874 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175874&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169412 363892712 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473553 COc1ccc(OC)c(CN2CCn3nnnc3C2c2cccc(F)c2F)c1 InChI=1S/C19H19F2N5O2/c1-27-13-6-7-16(28-2)12(10-13)11-25-8-9-26-19(22-23-24-26)18(25)14-4-3-5-15(20)17(14)21/h3-7,10,18H,8-9,11H2,1-2H3 LRLWMWLVTGJVFW-UHFFFAOYSA-N 175874 US9688684, Compound 71: 8-(2,3-Difluoro-phenyl)-7-(2,5-dimethoxy-benzyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 24950 US Patent 10.7270/Q2DB7ZZK aid1794990 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175874 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175874&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169412 363892712 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473554 CN(C)c1ccc(CN2CCn3nnnc3C2c2cccc(F)c2F)cc1 InChI=1S/C19H20F2N6/c1-25(2)14-8-6-13(7-9-14)12-26-10-11-27-19(22-23-24-27)18(26)15-4-3-5-16(20)17(15)21/h3-9,18H,10-12H2,1-2H3 UFJYXPQCRXNCNE-UHFFFAOYSA-N 175875 US9688684, Compound 72: {4-[8-(2,3-Difluoro-phenyl)-5,6-dihydro-8H-tetrazolo[1,5-a]pyrazin-7-ylmethyl]-phenyl}-dimethyl-amine Nuclear receptor ROR-gamma [238-497] 24950 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175875 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175875&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169454 363892713 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473555 Fc1ccccc1CN1CCn2nnnc2C1c1cccc(F)c1F InChI=1S/C17H14F3N5/c18-13-6-2-1-4-11(13)10-24-8-9-25-17(21-22-23-25)16(24)12-5-3-7-14(19)15(12)20/h1-7,16H,8-10H2 RWDHZGULZWRESD-UHFFFAOYSA-N 175876 US9688684, Compound 73: 8-(2,3-Difluoro-phenyl)-7-(2-fluoro-benzyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 24950 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175876 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175876&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169447 363892714 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473556 Fc1ccc(F)c(CN2CCn3nnnc3C2c2cccc(F)c2F)c1 InChI=1S/C17H13F4N5/c18-11-4-5-13(19)10(8-11)9-25-6-7-26-17(22-23-24-26)16(25)12-2-1-3-14(20)15(12)21/h1-5,8,16H,6-7,9H2 WMBHBWWLYALWFI-UHFFFAOYSA-N 175877 US9688684, Compound 74: 7-(2,5-Difluoro-benzyl)-8-(2,3-difluoro-phenyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 24950 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175877 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175877&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169461 363892715 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473557 Fc1cccc(CN2CCn3nnnc3C2c2cccc(F)c2F)c1 InChI=1S/C17H14F3N5/c18-12-4-1-3-11(9-12)10-24-7-8-25-17(21-22-23-25)16(24)13-5-2-6-14(19)15(13)20/h1-6,9,16H,7-8,10H2 DYGQXIICWDOAFF-UHFFFAOYSA-N 175878 US9688684, Compound 75: 8-(2,3-Difluoro-phenyl)-7-(3-fluoro-benzyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 5445 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175878 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175878&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169452 363892716 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473558 Fc1cccc(CN2CCn3nnnc3C2c2cccc(F)c2F)c1 InChI=1S/C17H14F3N5/c18-12-4-1-3-11(9-12)10-24-7-8-25-17(21-22-23-25)16(24)13-5-2-6-14(19)15(13)20/h1-6,9,16H,7-8,10H2 DYGQXIICWDOAFF-UHFFFAOYSA-N 175878 US9688684, Compound 75: 8-(2,3-Difluoro-phenyl)-7-(3-fluoro-benzyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 5445 US Patent 10.7270/Q2DB7ZZK aid1794990 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175878 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175878&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169452 363892716 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473559 CCOc1ccc(CN2CCn3nnnc3C2c2cccc(F)c2F)cc1 InChI=1S/C19H19F2N5O/c1-2-27-14-8-6-13(7-9-14)12-25-10-11-26-19(22-23-24-26)18(25)15-4-3-5-16(20)17(15)21/h3-9,18H,2,10-12H2,1H3 AJHXWGHTRVDEJA-UHFFFAOYSA-N 175879 US9688684, Compound 76: 8-(2,3-Difluoro-phenyl)-7-(4-ethoxy-benzyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 24950 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175879 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175879&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169427 363892717 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473560 Fc1cccc(C2N(Cc3cccs3)CCn3nnnc23)c1F InChI=1S/C15H13F2N5S/c16-12-5-1-4-11(13(12)17)14-15-18-19-20-22(15)7-6-21(14)9-10-3-2-8-23-10/h1-5,8,14H,6-7,9H2 ROCBNWUPCDAHHB-UHFFFAOYSA-N 175880 US9688684, Compound 77: 8-(2,3-Difluoro-phenyl)-7-thiophen-2-ylmethyl-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 5445 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175880&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169466 363892718 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473561 Fc1cccc(C2N(Cc3cccs3)CCn3nnnc23)c1F InChI=1S/C15H13F2N5S/c16-12-5-1-4-11(13(12)17)14-15-18-19-20-22(15)7-6-21(14)9-10-3-2-8-23-10/h1-5,8,14H,6-7,9H2 ROCBNWUPCDAHHB-UHFFFAOYSA-N 175880 US9688684, Compound 77: 8-(2,3-Difluoro-phenyl)-7-thiophen-2-ylmethyl-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 5445 US Patent 10.7270/Q2DB7ZZK aid1794990 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175880&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169466 363892718 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473562 Fc1cccc(CN2CCn3nnnc3C2c2cccc(F)c2F)c1F InChI=1S/C17H13F4N5/c18-12-5-1-3-10(14(12)20)9-25-7-8-26-17(22-23-24-26)16(25)11-4-2-6-13(19)15(11)21/h1-6,16H,7-9H2 CXKWIQWXHLUKLW-UHFFFAOYSA-N 175882 US9688684, Compound 79: 7-(2,3-Difluoro-benzyl)-8-(2,3-difluoro-phenyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 24950 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175882 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175882&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169547 363892719 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473563 COc1ccc(CN2CCn3nnnc3C2c2cccc(F)c2)c(OC)c1 InChI=1S/C19H20FN5O2/c1-26-16-7-6-14(17(11-16)27-2)12-24-8-9-25-19(21-22-23-25)18(24)13-4-3-5-15(20)10-13/h3-7,10-11,18H,8-9,12H2,1-2H3 PUESEFPVUAPOKF-UHFFFAOYSA-N 175883 US9688684, Compound 80: 7-(2,4-Dimethoxy-benzyl)-8-(3-fluoro-phenyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 5445 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175883 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175883&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169378 363892720 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473564 COc1ccc(CN2CCn3nnnc3C2c2cccc(F)c2)c(OC)c1 InChI=1S/C19H20FN5O2/c1-26-16-7-6-14(17(11-16)27-2)12-24-8-9-25-19(21-22-23-25)18(24)13-4-3-5-15(20)10-13/h3-7,10-11,18H,8-9,12H2,1-2H3 PUESEFPVUAPOKF-UHFFFAOYSA-N 175883 US9688684, Compound 80: 7-(2,4-Dimethoxy-benzyl)-8-(3-fluoro-phenyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 5445 US Patent 10.7270/Q2DB7ZZK aid1794990 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175883 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175883&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169378 363892720 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473565 Fc1cccc(c1)C1N(CCn2nnnc12)C(=O)c1cccc(Br)c1 InChI=1S/C17H13BrFN5O/c18-13-5-1-4-12(9-13)17(25)23-7-8-24-16(20-21-22-24)15(23)11-3-2-6-14(19)10-11/h1-6,9-10,15H,7-8H2 NLHOKXUMLCNGGR-UHFFFAOYSA-N 175885 US9688684, Compound 82: (3-Bromo-phenyl)-[8-(3-fluoro-phenyl)-5,6-dihydro-8H-tetrazolo[1,5-a]pyrazin-7-yl]-methanone Nuclear receptor ROR-gamma [238-497] 24950 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175885 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175885&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169477 363892721 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473566 Fc1ccc(cc1)C1N(Cc2cccnc2)CCn2nnnc12 InChI=1S/C16H15FN6/c17-14-5-3-13(4-6-14)15-16-19-20-21-23(16)9-8-22(15)11-12-2-1-7-18-10-12/h1-7,10,15H,8-9,11H2 UNUROPKXSOXALY-UHFFFAOYSA-N 175886 US9688684, Compound 83: 8-(4-Fluoro-phenyl)-7-pyridin-3-ylmethyl-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 24950 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175886 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175886&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169561 363892722 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473567 Fc1ccc(cc1)C1N(Cc2ccncc2)CCn2nnnc12 InChI=1S/C16H15FN6/c17-14-3-1-13(2-4-14)15-16-19-20-21-23(16)10-9-22(15)11-12-5-7-18-8-6-12/h1-8,15H,9-11H2 JXLHKXPSTBGACV-UHFFFAOYSA-N 175887 US9688684, Compound 84: 8-(4-Fluoro-phenyl)-7-pyridin-4-ylmethyl-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 5445 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175887 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175887&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169422 363892723 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473568 Fc1ccc(cc1)C1N(Cc2ccncc2)CCn2nnnc12 InChI=1S/C16H15FN6/c17-14-3-1-13(2-4-14)15-16-19-20-21-23(16)10-9-22(15)11-12-5-7-18-8-6-12/h1-8,15H,9-11H2 JXLHKXPSTBGACV-UHFFFAOYSA-N 175887 US9688684, Compound 84: 8-(4-Fluoro-phenyl)-7-pyridin-4-ylmethyl-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 500 US Patent 10.7270/Q2DB7ZZK aid1794990 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175887 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175887&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169422 363892723 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473569 Cn1ccc(CN2CCn3nnnc3C2c2ccc(F)cc2)n1 InChI=1S/C15H16FN7/c1-21-7-6-13(18-21)10-22-8-9-23-15(17-19-20-23)14(22)11-2-4-12(16)5-3-11/h2-7,14H,8-10H2,1H3 NQANUVDHTLHHRQ-UHFFFAOYSA-N 175888 US9688684, Compound 85: 8-(4-Fluoro-phenyl)-7-(1-methyl-1H-pyrazol-3-ylmethyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 24950 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175888 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175888&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169456 363892724 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473570 Cc1cccc(CN2CCn3nnnc3C2c2ccccn2)c1 InChI=1S/C17H18N6/c1-13-5-4-6-14(11-13)12-22-9-10-23-17(19-20-21-23)16(22)15-7-2-3-8-18-15/h2-8,11,16H,9-10,12H2,1H3 TYISHGCKRDZIRP-UHFFFAOYSA-N 175889 US9688684, Compound 86: 7-(3-Methyl-benzyl)-8-pyridin-2-yl-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 24950 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175889 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175889&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169503 363892725 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473571 Cc1cccc(CN2CCn3nnnc3C2c2ccncc2)c1 InChI=1S/C17H18N6/c1-13-3-2-4-14(11-13)12-22-9-10-23-17(19-20-21-23)16(22)15-5-7-18-8-6-15/h2-8,11,16H,9-10,12H2,1H3 WWGDAIOHVWCNCL-UHFFFAOYSA-N 175890 US9688684, Compound 87: 7-(3-Methyl-benzyl)-8-pyridin-4-yl-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 24950 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175890 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175890&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169375 363892726 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473572 CC(C)Oc1ccc(cc1)C1N(Cc2ccccc2)CCn2nnnc12 InChI=1S/C20H23N5O/c1-15(2)26-18-10-8-17(9-11-18)19-20-21-22-23-25(20)13-12-24(19)14-16-6-4-3-5-7-16/h3-11,15,19H,12-14H2,1-2H3 ZREBPJHARXZMNT-UHFFFAOYSA-N 175891 US9688684, Compound 88: 7-Benzyl-8-(4-isopropoxy-phenyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 500 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175891 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175891&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169493 363892727 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473573 CC(C)Oc1ccc(cc1)C1N(Cc2ccccc2)CCn2nnnc12 InChI=1S/C20H23N5O/c1-15(2)26-18-10-8-17(9-11-18)19-20-21-22-23-25(20)13-12-24(19)14-16-6-4-3-5-7-16/h3-11,15,19H,12-14H2,1-2H3 ZREBPJHARXZMNT-UHFFFAOYSA-N 175891 US9688684, Compound 88: 7-Benzyl-8-(4-isopropoxy-phenyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 5445 US Patent 10.7270/Q2DB7ZZK aid1794990 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175891 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175891&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169493 363892727 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473574 Fc1cccc(c1)C1N(Cc2ccccc2)CCn2nnnc12 InChI=1S/C17H16FN5/c18-15-8-4-7-14(11-15)16-17-19-20-21-23(17)10-9-22(16)12-13-5-2-1-3-6-13/h1-8,11,16H,9-10,12H2 GRWNITPUKJMBAZ-UHFFFAOYSA-N 175892 US9688684, Compound 89: 7-Benzyl-8-(3-fluoro-phenyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 500 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175892 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175892&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169417 363892728 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473575 Fc1cccc(c1)C1N(Cc2ccccc2)CCn2nnnc12 InChI=1S/C17H16FN5/c18-15-8-4-7-14(11-15)16-17-19-20-21-23(17)10-9-22(16)12-13-5-2-1-3-6-13/h1-8,11,16H,9-10,12H2 GRWNITPUKJMBAZ-UHFFFAOYSA-N 175892 US9688684, Compound 89: 7-Benzyl-8-(3-fluoro-phenyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 5445 US Patent 10.7270/Q2DB7ZZK aid1794990 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175892 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175892&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169417 363892728 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473576 CCc1ccc(cc1)C1N(Cc2ccccc2)CCn2nnnc12 InChI=1S/C19H21N5/c1-2-15-8-10-17(11-9-15)18-19-20-21-22-24(19)13-12-23(18)14-16-6-4-3-5-7-16/h3-11,18H,2,12-14H2,1H3 JVFYQOIGVOCBBT-UHFFFAOYSA-N 175893 US9688684, Compound 90: 7-Benzyl-8-(4-ethyl-phenyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 500 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175893 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175893&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169530 363892729 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473577 CCc1ccc(cc1)C1N(Cc2ccccc2)CCn2nnnc12 InChI=1S/C19H21N5/c1-2-15-8-10-17(11-9-15)18-19-20-21-22-24(19)13-12-23(18)14-16-6-4-3-5-7-16/h3-11,18H,2,12-14H2,1H3 JVFYQOIGVOCBBT-UHFFFAOYSA-N 175893 US9688684, Compound 90: 7-Benzyl-8-(4-ethyl-phenyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 5445 US Patent 10.7270/Q2DB7ZZK aid1794990 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175893 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175893&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169530 363892729 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473578 CCc1ccc(cc1)C1N(Cc2ccccc2)CCn2nnnc12 InChI=1S/C19H21N5/c1-2-15-8-10-17(11-9-15)18-19-20-21-22-24(19)13-12-23(18)14-16-6-4-3-5-7-16/h3-11,18H,2,12-14H2,1H3 JVFYQOIGVOCBBT-UHFFFAOYSA-N 175893 US9688684, Compound 90: 7-Benzyl-8-(4-ethyl-phenyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 24950 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175893 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175893&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169530 363892729 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473579 CCc1ccc(cc1)C1N(Cc2ccccc2)CCn2nnnc12 InChI=1S/C19H21N5/c1-2-15-8-10-17(11-9-15)18-19-20-21-22-24(19)13-12-23(18)14-16-6-4-3-5-7-16/h3-11,18H,2,12-14H2,1H3 JVFYQOIGVOCBBT-UHFFFAOYSA-N 175893 US9688684, Compound 90: 7-Benzyl-8-(4-ethyl-phenyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 500 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175893 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175893&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169530 363892729 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473580 CCc1ccc(cc1)C1N(Cc2ccccc2)CCn2nnnc12 InChI=1S/C19H21N5/c1-2-15-8-10-17(11-9-15)18-19-20-21-22-24(19)13-12-23(18)14-16-6-4-3-5-7-16/h3-11,18H,2,12-14H2,1H3 JVFYQOIGVOCBBT-UHFFFAOYSA-N 175893 US9688684, Compound 90: 7-Benzyl-8-(4-ethyl-phenyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 5445 US Patent 10.7270/Q2DB7ZZK aid1794990 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175893 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175893&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169530 363892729 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473581 Fc1ccc(CN2CCn3nnnc3C2c2cccc(F)c2)cc1 InChI=1S/C17H15F2N5/c18-14-6-4-12(5-7-14)11-23-8-9-24-17(20-21-22-24)16(23)13-2-1-3-15(19)10-13/h1-7,10,16H,8-9,11H2 WONDFDMPHJOWPT-UHFFFAOYSA-N 175894 US9688684, Compound 91: 7-(4-Fluoro-benzyl)-8-(3-fluoro-phenyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 5445 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175894 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175894&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169406 363892730 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473582 Fc1ccc(CN2CCn3nnnc3C2c2cccc(F)c2)cc1 InChI=1S/C17H15F2N5/c18-14-6-4-12(5-7-14)11-23-8-9-24-17(20-21-22-24)16(23)13-2-1-3-15(19)10-13/h1-7,10,16H,8-9,11H2 WONDFDMPHJOWPT-UHFFFAOYSA-N 175894 US9688684, Compound 91: 7-(4-Fluoro-benzyl)-8-(3-fluoro-phenyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 500 US Patent 10.7270/Q2DB7ZZK aid1794990 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175894 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175894&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169406 363892730 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473583 Fc1ccc(CN2CCn3nnnc3C2c2cccc(F)c2)cc1 InChI=1S/C17H15F2N5/c18-14-6-4-12(5-7-14)11-23-8-9-24-17(20-21-22-24)16(23)13-2-1-3-15(19)10-13/h1-7,10,16H,8-9,11H2 WONDFDMPHJOWPT-UHFFFAOYSA-N 175894 US9688684, Compound 91: 7-(4-Fluoro-benzyl)-8-(3-fluoro-phenyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 24950 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175894 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175894&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169406 363892730 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473584 Fc1ccc(CN2CCn3nnnc3C2c2cccc(F)c2)cc1 InChI=1S/C17H15F2N5/c18-14-6-4-12(5-7-14)11-23-8-9-24-17(20-21-22-24)16(23)13-2-1-3-15(19)10-13/h1-7,10,16H,8-9,11H2 WONDFDMPHJOWPT-UHFFFAOYSA-N 175894 US9688684, Compound 91: 7-(4-Fluoro-benzyl)-8-(3-fluoro-phenyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 5445 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175894 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175894&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169406 363892730 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473585 Fc1ccc(CN2CCn3nnnc3C2c2cccc(F)c2)cc1 InChI=1S/C17H15F2N5/c18-14-6-4-12(5-7-14)11-23-8-9-24-17(20-21-22-24)16(23)13-2-1-3-15(19)10-13/h1-7,10,16H,8-9,11H2 WONDFDMPHJOWPT-UHFFFAOYSA-N 175894 US9688684, Compound 91: 7-(4-Fluoro-benzyl)-8-(3-fluoro-phenyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 5445 US Patent 10.7270/Q2DB7ZZK aid1794990 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175894 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175894&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169406 363892730 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473586 Cc1cccc(c1)C1N(Cc2cccc(Br)c2)CCn2nnnc12 InChI=1S/C18H18BrN5/c1-13-4-2-6-15(10-13)17-18-20-21-22-24(18)9-8-23(17)12-14-5-3-7-16(19)11-14/h2-7,10-11,17H,8-9,12H2,1H3 CMBCCXBVSAKMBX-UHFFFAOYSA-N 175895 US9688684, Compound 92: 7-(3-Bromo-benzyl)-8-m-tolyl-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 500 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175895 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175895&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169476 363892731 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473587 Cc1cccc(c1)C1N(Cc2cccc(Br)c2)CCn2nnnc12 InChI=1S/C18H18BrN5/c1-13-4-2-6-15(10-13)17-18-20-21-22-24(18)9-8-23(17)12-14-5-3-7-16(19)11-14/h2-7,10-11,17H,8-9,12H2,1H3 CMBCCXBVSAKMBX-UHFFFAOYSA-N 175895 US9688684, Compound 92: 7-(3-Bromo-benzyl)-8-m-tolyl-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 5445 US Patent 10.7270/Q2DB7ZZK aid1794990 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175895 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175895&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169476 363892731 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473588 Cc1cccc(c1)C1N(Cc2cccc(Br)c2)CCn2nnnc12 InChI=1S/C18H18BrN5/c1-13-4-2-6-15(10-13)17-18-20-21-22-24(18)9-8-23(17)12-14-5-3-7-16(19)11-14/h2-7,10-11,17H,8-9,12H2,1H3 CMBCCXBVSAKMBX-UHFFFAOYSA-N 175895 US9688684, Compound 92: 7-(3-Bromo-benzyl)-8-m-tolyl-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 24950 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175895 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175895&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169476 363892731 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473589 Cc1cccc(c1)C1N(Cc2cccc(Br)c2)CCn2nnnc12 InChI=1S/C18H18BrN5/c1-13-4-2-6-15(10-13)17-18-20-21-22-24(18)9-8-23(17)12-14-5-3-7-16(19)11-14/h2-7,10-11,17H,8-9,12H2,1H3 CMBCCXBVSAKMBX-UHFFFAOYSA-N 175895 US9688684, Compound 92: 7-(3-Bromo-benzyl)-8-m-tolyl-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 500 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175895 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175895&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169476 363892731 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473590 Cc1cccc(c1)C1N(Cc2cccc(Br)c2)CCn2nnnc12 InChI=1S/C18H18BrN5/c1-13-4-2-6-15(10-13)17-18-20-21-22-24(18)9-8-23(17)12-14-5-3-7-16(19)11-14/h2-7,10-11,17H,8-9,12H2,1H3 CMBCCXBVSAKMBX-UHFFFAOYSA-N 175895 US9688684, Compound 92: 7-(3-Bromo-benzyl)-8-m-tolyl-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 5445 US Patent 10.7270/Q2DB7ZZK aid1794990 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175895 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175895&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169476 363892731 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473591 Cc1cccc(CN2CCn3nnnc3C2c2ccc(F)cc2)c1 InChI=1S/C18H18FN5/c1-13-3-2-4-14(11-13)12-23-9-10-24-18(20-21-22-24)17(23)15-5-7-16(19)8-6-15/h2-8,11,17H,9-10,12H2,1H3 PBUKOLVHSUIPDF-UHFFFAOYSA-N 175896 US9688684, Compound 93: 8-(4-Fluoro-phenyl)-7-(3-methyl-benzyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 500 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175896 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175896&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169470 363892732 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473592 Cc1cccc(CN2CCn3nnnc3C2c2ccc(F)cc2)c1 InChI=1S/C18H18FN5/c1-13-3-2-4-14(11-13)12-23-9-10-24-18(20-21-22-24)17(23)15-5-7-16(19)8-6-15/h2-8,11,17H,9-10,12H2,1H3 PBUKOLVHSUIPDF-UHFFFAOYSA-N 175896 US9688684, Compound 93: 8-(4-Fluoro-phenyl)-7-(3-methyl-benzyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 24950 US Patent 10.7270/Q2DB7ZZK aid1794990 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175896 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175896&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169470 363892732 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473593 Cc1cccc(CN2CCn3nnnc3C2c2ccc(F)cc2)c1 InChI=1S/C18H18FN5/c1-13-3-2-4-14(11-13)12-23-9-10-24-18(20-21-22-24)17(23)15-5-7-16(19)8-6-15/h2-8,11,17H,9-10,12H2,1H3 PBUKOLVHSUIPDF-UHFFFAOYSA-N 175896 US9688684, Compound 93: 8-(4-Fluoro-phenyl)-7-(3-methyl-benzyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 500 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175896 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175896&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169470 363892732 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473594 Cc1cccc(CN2CCn3nnnc3C2c2ccc(F)cc2)c1 InChI=1S/C18H18FN5/c1-13-3-2-4-14(11-13)12-23-9-10-24-18(20-21-22-24)17(23)15-5-7-16(19)8-6-15/h2-8,11,17H,9-10,12H2,1H3 PBUKOLVHSUIPDF-UHFFFAOYSA-N 175896 US9688684, Compound 93: 8-(4-Fluoro-phenyl)-7-(3-methyl-benzyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 5445 US Patent 10.7270/Q2DB7ZZK aid1794990 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175896 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175896&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169470 363892732 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473595 Cc1cccc(CN2CCn3nnnc3C2c2ccc(F)cc2)c1 InChI=1S/C18H18FN5/c1-13-3-2-4-14(11-13)12-23-9-10-24-18(20-21-22-24)17(23)15-5-7-16(19)8-6-15/h2-8,11,17H,9-10,12H2,1H3 PBUKOLVHSUIPDF-UHFFFAOYSA-N 175896 US9688684, Compound 93: 8-(4-Fluoro-phenyl)-7-(3-methyl-benzyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 24950 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175896 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175896&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169470 363892732 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473596 Brc1cccc(c1)C1N(Cc2ccccc2)CCn2nnnc12 InChI=1S/C17H16BrN5/c18-15-8-4-7-14(11-15)16-17-19-20-21-23(17)10-9-22(16)12-13-5-2-1-3-6-13/h1-8,11,16H,9-10,12H2 ZWSMKBLEYUHUJK-UHFFFAOYSA-N 175897 US9688684, Compound 94: 7-Benzyl-8-(3-bromo-phenyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 500 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175897 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175897&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169514 363892733 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473597 Brc1cccc(c1)C1N(Cc2ccccc2)CCn2nnnc12 InChI=1S/C17H16BrN5/c18-15-8-4-7-14(11-15)16-17-19-20-21-23(17)10-9-22(16)12-13-5-2-1-3-6-13/h1-8,11,16H,9-10,12H2 ZWSMKBLEYUHUJK-UHFFFAOYSA-N 175897 US9688684, Compound 94: 7-Benzyl-8-(3-bromo-phenyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 5445 US Patent 10.7270/Q2DB7ZZK aid1794990 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175897 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175897&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169514 363892733 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473598 Cc1cccc(CN2CCn3nnnc3C2c2ccc3OCCOc3c2)c1 InChI=1S/C20H21N5O2/c1-14-3-2-4-15(11-14)13-24-7-8-25-20(21-22-23-25)19(24)16-5-6-17-18(12-16)27-10-9-26-17/h2-6,11-12,19H,7-10,13H2,1H3 FLNJGAKMIMIYES-UHFFFAOYSA-N 175898 US9688684, Compound 95: 8-(2,3-Dihydro-benzo[1,4]dioxin-6-yl)-7-(3-methyl-benzyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 500 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175898 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175898&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169425 363892734 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473599 Cc1cccc(CN2CCn3nnnc3C2c2ccc3OCCOc3c2)c1 InChI=1S/C20H21N5O2/c1-14-3-2-4-15(11-14)13-24-7-8-25-20(21-22-23-25)19(24)16-5-6-17-18(12-16)27-10-9-26-17/h2-6,11-12,19H,7-10,13H2,1H3 FLNJGAKMIMIYES-UHFFFAOYSA-N 175898 US9688684, Compound 95: 8-(2,3-Dihydro-benzo[1,4]dioxin-6-yl)-7-(3-methyl-benzyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 5445 US Patent 10.7270/Q2DB7ZZK aid1794990 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175898 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175898&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169425 363892734 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473600 Fc1ccc(cc1)C1N(Cc2cccc(Br)c2)CCn2nnnc12 InChI=1S/C17H15BrFN5/c18-14-3-1-2-12(10-14)11-23-8-9-24-17(20-21-22-24)16(23)13-4-6-15(19)7-5-13/h1-7,10,16H,8-9,11H2 YZQUYOXRVVXYEK-UHFFFAOYSA-N 175899 US9688684, Compound 96: 7-(3-Bromo-benzyl)-8-(4-fluoro-phenyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 500 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175899 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175899&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169380 363892735 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473601 Fc1ccc(cc1)C1N(Cc2cccc(Br)c2)CCn2nnnc12 InChI=1S/C17H15BrFN5/c18-14-3-1-2-12(10-14)11-23-8-9-24-17(20-21-22-24)16(23)13-4-6-15(19)7-5-13/h1-7,10,16H,8-9,11H2 YZQUYOXRVVXYEK-UHFFFAOYSA-N 175899 US9688684, Compound 96: 7-(3-Bromo-benzyl)-8-(4-fluoro-phenyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 5445 US Patent 10.7270/Q2DB7ZZK aid1794990 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175899 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175899&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169380 363892735 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473602 Fc1ccc(cc1)C1N(Cc2cccc(Br)c2)CCn2nnnc12 InChI=1S/C17H15BrFN5/c18-14-3-1-2-12(10-14)11-23-8-9-24-17(20-21-22-24)16(23)13-4-6-15(19)7-5-13/h1-7,10,16H,8-9,11H2 YZQUYOXRVVXYEK-UHFFFAOYSA-N 175899 US9688684, Compound 96: 7-(3-Bromo-benzyl)-8-(4-fluoro-phenyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 500 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175899 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175899&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169380 363892735 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473603 Fc1ccc(cc1)C1N(Cc2cccc(Br)c2)CCn2nnnc12 InChI=1S/C17H15BrFN5/c18-14-3-1-2-12(10-14)11-23-8-9-24-17(20-21-22-24)16(23)13-4-6-15(19)7-5-13/h1-7,10,16H,8-9,11H2 YZQUYOXRVVXYEK-UHFFFAOYSA-N 175899 US9688684, Compound 96: 7-(3-Bromo-benzyl)-8-(4-fluoro-phenyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 5445 US Patent 10.7270/Q2DB7ZZK aid1794990 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175899 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175899&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169380 363892735 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473604 Fc1ccc(cc1)C1N(Cc2cccc(Br)c2)CCn2nnnc12 InChI=1S/C17H15BrFN5/c18-14-3-1-2-12(10-14)11-23-8-9-24-17(20-21-22-24)16(23)13-4-6-15(19)7-5-13/h1-7,10,16H,8-9,11H2 YZQUYOXRVVXYEK-UHFFFAOYSA-N 175899 US9688684, Compound 96: 7-(3-Bromo-benzyl)-8-(4-fluoro-phenyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 24950 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175899 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175899&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169380 363892735 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473605 Cc1cccc(CN2CCn3nnnc3C2c2ccc(Cl)cc2)c1 InChI=1S/C18H18ClN5/c1-13-3-2-4-14(11-13)12-23-9-10-24-18(20-21-22-24)17(23)15-5-7-16(19)8-6-15/h2-8,11,17H,9-10,12H2,1H3 VMXZCWQFAMJGBP-UHFFFAOYSA-N 175900 US9688684, Compound 97: 8-(4-Chloro-phenyl)-7-(3-methyl-benzyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 500 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175900 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175900&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169467 363892736 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473606 Cc1cccc(CN2CCn3nnnc3C2c2ccc(Cl)cc2)c1 InChI=1S/C18H18ClN5/c1-13-3-2-4-14(11-13)12-23-9-10-24-18(20-21-22-24)17(23)15-5-7-16(19)8-6-15/h2-8,11,17H,9-10,12H2,1H3 VMXZCWQFAMJGBP-UHFFFAOYSA-N 175900 US9688684, Compound 97: 8-(4-Chloro-phenyl)-7-(3-methyl-benzyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 5445 US Patent 10.7270/Q2DB7ZZK aid1794990 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175900 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175900&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169467 363892736 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473607 CCCCOc1ccc(cc1)C1N(Cc2ccccc2)CCn2nnnc12 InChI=1S/C21H25N5O/c1-2-3-15-27-19-11-9-18(10-12-19)20-21-22-23-24-26(21)14-13-25(20)16-17-7-5-4-6-8-17/h4-12,20H,2-3,13-16H2,1H3 GJKBDIQPAZDQPN-UHFFFAOYSA-N 175901 US9688684, Compound 98: 7-Benzyl-8-(4-butoxy-phenyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 500 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175901 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175901&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169367 363892737 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473608 CCCCOc1ccc(cc1)C1N(Cc2ccccc2)CCn2nnnc12 InChI=1S/C21H25N5O/c1-2-3-15-27-19-11-9-18(10-12-19)20-21-22-23-24-26(21)14-13-25(20)16-17-7-5-4-6-8-17/h4-12,20H,2-3,13-16H2,1H3 GJKBDIQPAZDQPN-UHFFFAOYSA-N 175901 US9688684, Compound 98: 7-Benzyl-8-(4-butoxy-phenyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 5445 US Patent 10.7270/Q2DB7ZZK aid1794990 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175901 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175901&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169367 363892737 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473609 CCCCOc1ccc(cc1)C1N(Cc2ccccc2)CCn2nnnc12 InChI=1S/C21H25N5O/c1-2-3-15-27-19-11-9-18(10-12-19)20-21-22-23-24-26(21)14-13-25(20)16-17-7-5-4-6-8-17/h4-12,20H,2-3,13-16H2,1H3 GJKBDIQPAZDQPN-UHFFFAOYSA-N 175901 US9688684, Compound 98: 7-Benzyl-8-(4-butoxy-phenyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 500 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175901 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175901&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169367 363892737 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473610 CCCCOc1ccc(cc1)C1N(Cc2ccccc2)CCn2nnnc12 InChI=1S/C21H25N5O/c1-2-3-15-27-19-11-9-18(10-12-19)20-21-22-23-24-26(21)14-13-25(20)16-17-7-5-4-6-8-17/h4-12,20H,2-3,13-16H2,1H3 GJKBDIQPAZDQPN-UHFFFAOYSA-N 175901 US9688684, Compound 98: 7-Benzyl-8-(4-butoxy-phenyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 5445 US Patent 10.7270/Q2DB7ZZK aid1794990 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175901 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175901&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169367 363892737 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473611 CCCCOc1ccc(cc1)C1N(Cc2ccccc2)CCn2nnnc12 InChI=1S/C21H25N5O/c1-2-3-15-27-19-11-9-18(10-12-19)20-21-22-23-24-26(21)14-13-25(20)16-17-7-5-4-6-8-17/h4-12,20H,2-3,13-16H2,1H3 GJKBDIQPAZDQPN-UHFFFAOYSA-N 175901 US9688684, Compound 98: 7-Benzyl-8-(4-butoxy-phenyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 24950 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175901 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175901&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169367 363892737 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473612 CC(C)c1ccc(cc1)C1N(Cc2cccc(C)c2)CCn2nnnc12 InChI=1S/C21H25N5/c1-15(2)18-7-9-19(10-8-18)20-21-22-23-24-26(21)12-11-25(20)14-17-6-4-5-16(3)13-17/h4-10,13,15,20H,11-12,14H2,1-3H3 AURRLSIKXKVJBZ-UHFFFAOYSA-N 175902 US9688684, Compound 99: 8-(4-Isopropoxy-phenyl)-7-(3-methyl-benzyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 500 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175902 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175902&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 133081656 363892738 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473613 CC(C)c1ccc(cc1)C1N(Cc2cccc(C)c2)CCn2nnnc12 InChI=1S/C21H25N5/c1-15(2)18-7-9-19(10-8-18)20-21-22-23-24-26(21)12-11-25(20)14-17-6-4-5-16(3)13-17/h4-10,13,15,20H,11-12,14H2,1-3H3 AURRLSIKXKVJBZ-UHFFFAOYSA-N 175902 US9688684, Compound 99: 8-(4-Isopropoxy-phenyl)-7-(3-methyl-benzyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 5445 US Patent 10.7270/Q2DB7ZZK aid1794990 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175902 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175902&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 133081656 363892738 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473614 Cc1cccc(c1)C1N(Cc2ccccc2)CCn2nnnc12 InChI=1S/C18H19N5/c1-14-6-5-9-16(12-14)17-18-19-20-21-23(18)11-10-22(17)13-15-7-3-2-4-8-15/h2-9,12,17H,10-11,13H2,1H3 XXKHXYRVASDTRO-UHFFFAOYSA-N 175903 US9688684, Compound 100: 7-Benzyl-8-m-tolyl-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 500 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175903 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175903&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169428 363892739 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473615 Cc1cccc(c1)C1N(Cc2ccccc2)CCn2nnnc12 InChI=1S/C18H19N5/c1-14-6-5-9-16(12-14)17-18-19-20-21-23(18)11-10-22(17)13-15-7-3-2-4-8-15/h2-9,12,17H,10-11,13H2,1H3 XXKHXYRVASDTRO-UHFFFAOYSA-N 175903 US9688684, Compound 100: 7-Benzyl-8-m-tolyl-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 24950 US Patent 10.7270/Q2DB7ZZK aid1794990 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175903 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175903&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169428 363892739 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473616 Fc1cc(F)cc(c1)C1N(Cc2ccccc2)CCn2nnnc12 InChI=1S/C17H15F2N5/c18-14-8-13(9-15(19)10-14)16-17-20-21-22-24(17)7-6-23(16)11-12-4-2-1-3-5-12/h1-5,8-10,16H,6-7,11H2 YVHIHEWJIWYLMK-UHFFFAOYSA-N 175904 US9688684, Compound 101: 7-Benzyl-8-(3,5-difluoro-phenyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 500 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175904 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175904&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169403 363892740 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473617 Fc1cc(F)cc(c1)C1N(Cc2ccccc2)CCn2nnnc12 InChI=1S/C17H15F2N5/c18-14-8-13(9-15(19)10-14)16-17-20-21-22-24(17)7-6-23(16)11-12-4-2-1-3-5-12/h1-5,8-10,16H,6-7,11H2 YVHIHEWJIWYLMK-UHFFFAOYSA-N 175904 US9688684, Compound 101: 7-Benzyl-8-(3,5-difluoro-phenyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 24950 US Patent 10.7270/Q2DB7ZZK aid1794990 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175904 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175904&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169403 363892740 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473618 Fc1ccc(cc1)C1N(Cc2ccccc2)CCn2nnnc12 InChI=1S/C17H16FN5/c18-15-8-6-14(7-9-15)16-17-19-20-21-23(17)11-10-22(16)12-13-4-2-1-3-5-13/h1-9,16H,10-12H2 NMPCTHGPCIJIFK-UHFFFAOYSA-N 175905 US9688684, Compound 102: 7-Benzyl-8-(4-fluoro-phenyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 500 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175905 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175905&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169506 363892741 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473619 Fc1ccc(cc1)C1N(Cc2ccccc2)CCn2nnnc12 InChI=1S/C17H16FN5/c18-15-8-6-14(7-9-15)16-17-19-20-21-23(17)11-10-22(16)12-13-4-2-1-3-5-13/h1-9,16H,10-12H2 NMPCTHGPCIJIFK-UHFFFAOYSA-N 175905 US9688684, Compound 102: 7-Benzyl-8-(4-fluoro-phenyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 24950 US Patent 10.7270/Q2DB7ZZK aid1794990 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175905 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175905&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169506 363892741 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473620 CCCCOc1ccc(cc1)C1N(Cc2cccc(C)c2)CCn2nnnc12 InChI=1S/C22H27N5O/c1-3-4-14-28-20-10-8-19(9-11-20)21-22-23-24-25-27(22)13-12-26(21)16-18-7-5-6-17(2)15-18/h5-11,15,21H,3-4,12-14,16H2,1-2H3 JRMSNFUYRQVNAU-UHFFFAOYSA-N 175906 US9688684, Compound 103: 8-(4-Butoxy-phenyl)-7-(3-methyl-benzyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 500 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175906 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175906&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169446 363892742 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473621 CCCCOc1ccc(cc1)C1N(Cc2cccc(C)c2)CCn2nnnc12 InChI=1S/C22H27N5O/c1-3-4-14-28-20-10-8-19(9-11-20)21-22-23-24-25-27(22)13-12-26(21)16-18-7-5-6-17(2)15-18/h5-11,15,21H,3-4,12-14,16H2,1-2H3 JRMSNFUYRQVNAU-UHFFFAOYSA-N 175906 US9688684, Compound 103: 8-(4-Butoxy-phenyl)-7-(3-methyl-benzyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 5445 US Patent 10.7270/Q2DB7ZZK aid1794990 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175906 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175906&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169446 363892742 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473622 CC(C)c1ccc(cc1)C1N(Cc2cccc(Br)c2)CCn2nnnc12 InChI=1S/C20H22BrN5/c1-14(2)16-6-8-17(9-7-16)19-20-22-23-24-26(20)11-10-25(19)13-15-4-3-5-18(21)12-15/h3-9,12,14,19H,10-11,13H2,1-2H3 ZMAOJTPPZJWFJA-UHFFFAOYSA-N 175907 US9688684, Compound 104: 7-(3-Bromo-benzyl)-8-(4-isopropyl-phenyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 500 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175907 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175907&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169468 363892743 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473623 CC(C)c1ccc(cc1)C1N(Cc2cccc(Br)c2)CCn2nnnc12 InChI=1S/C20H22BrN5/c1-14(2)16-6-8-17(9-7-16)19-20-22-23-24-26(20)11-10-25(19)13-15-4-3-5-18(21)12-15/h3-9,12,14,19H,10-11,13H2,1-2H3 ZMAOJTPPZJWFJA-UHFFFAOYSA-N 175907 US9688684, Compound 104: 7-(3-Bromo-benzyl)-8-(4-isopropyl-phenyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 5445 US Patent 10.7270/Q2DB7ZZK aid1794990 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175907 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175907&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169468 363892743 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473624 Cc1cccc(CN2CCn3nnnc3C2c2ccccc2)c1 InChI=1S/C18H19N5/c1-14-6-5-7-15(12-14)13-22-10-11-23-18(19-20-21-23)17(22)16-8-3-2-4-9-16/h2-9,12,17H,10-11,13H2,1H3 QHNVZIZNPSTNMD-UHFFFAOYSA-N 175908 US9688684, Compound 105: 7-(3-Methyl-benzyl)-8-phenyl-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 500 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175908 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175908&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169409 363892744 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473625 Cc1cccc(CN2CCn3nnnc3C2c2ccccc2)c1 InChI=1S/C18H19N5/c1-14-6-5-7-15(12-14)13-22-10-11-23-18(19-20-21-23)17(22)16-8-3-2-4-9-16/h2-9,12,17H,10-11,13H2,1H3 QHNVZIZNPSTNMD-UHFFFAOYSA-N 175908 US9688684, Compound 105: 7-(3-Methyl-benzyl)-8-phenyl-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 24950 US Patent 10.7270/Q2DB7ZZK aid1794990 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175908 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175908&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169409 363892744 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473626 Clc1ccc(cc1)C1N(Cc2cccs2)CCn2nnnc12 InChI=1S/C15H14ClN5S/c16-12-5-3-11(4-6-12)14-15-17-18-19-21(15)8-7-20(14)10-13-2-1-9-22-13/h1-6,9,14H,7-8,10H2 SYMOHTUKFYIOEI-UHFFFAOYSA-N 175909 US9688684, Compound 106: 8-(4-Chloro-phenyl)-7-thiophen-2-ylmethyl-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 500 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175909 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175909&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169394 363892745 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473627 Clc1ccc(cc1)C1N(Cc2cccs2)CCn2nnnc12 InChI=1S/C15H14ClN5S/c16-12-5-3-11(4-6-12)14-15-17-18-19-21(15)8-7-20(14)10-13-2-1-9-22-13/h1-6,9,14H,7-8,10H2 SYMOHTUKFYIOEI-UHFFFAOYSA-N 175909 US9688684, Compound 106: 8-(4-Chloro-phenyl)-7-thiophen-2-ylmethyl-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 24950 US Patent 10.7270/Q2DB7ZZK aid1794990 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175909 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175909&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169394 363892745 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473628 Cc1cc(C)cc(c1)C1N(Cc2cccc(Br)c2)CCn2nnnc12 InChI=1S/C19H20BrN5/c1-13-8-14(2)10-16(9-13)18-19-21-22-23-25(19)7-6-24(18)12-15-4-3-5-17(20)11-15/h3-5,8-11,18H,6-7,12H2,1-2H3 JZPHPAGPMLICCH-UHFFFAOYSA-N 175910 US9688684, Compound 107: 7-(3-Bromo-benzyl)-8-(3,5-difluoro-phenyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 500 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175910 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175910&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 133081657 363892746 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473629 Cc1cc(C)cc(c1)C1N(Cc2cccc(Br)c2)CCn2nnnc12 InChI=1S/C19H20BrN5/c1-13-8-14(2)10-16(9-13)18-19-21-22-23-25(19)7-6-24(18)12-15-4-3-5-17(20)11-15/h3-5,8-11,18H,6-7,12H2,1-2H3 JZPHPAGPMLICCH-UHFFFAOYSA-N 175910 US9688684, Compound 107: 7-(3-Bromo-benzyl)-8-(3,5-difluoro-phenyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 24950 US Patent 10.7270/Q2DB7ZZK aid1794990 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175910 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175910&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 133081657 363892746 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473630 Fc1ccc(F)c(c1)C1N(Cc2cccc(Br)c2)CCn2nnnc12 InChI=1S/C17H14BrF2N5/c18-12-3-1-2-11(8-12)10-24-6-7-25-17(21-22-23-25)16(24)14-9-13(19)4-5-15(14)20/h1-5,8-9,16H,6-7,10H2 HUKJRRACKIWDFY-UHFFFAOYSA-N 175911 US9688684, Compound 108: 7-(3-Bromo-benzyl)-8-(2,5-difluoro-phenyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 500 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175911 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175911&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169397 363892747 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473631 Fc1ccc(F)c(c1)C1N(Cc2cccc(Br)c2)CCn2nnnc12 InChI=1S/C17H14BrF2N5/c18-12-3-1-2-11(8-12)10-24-6-7-25-17(21-22-23-25)16(24)14-9-13(19)4-5-15(14)20/h1-5,8-9,16H,6-7,10H2 HUKJRRACKIWDFY-UHFFFAOYSA-N 175911 US9688684, Compound 108: 7-(3-Bromo-benzyl)-8-(2,5-difluoro-phenyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 24950 US Patent 10.7270/Q2DB7ZZK aid1794990 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175911 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175911&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169397 363892747 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473632 CN(C)c1ccc(cc1)C1N(Cc2cccc(Br)c2)CCn2nnnc12 InChI=1S/C19H21BrN6/c1-24(2)17-8-6-15(7-9-17)18-19-21-22-23-26(19)11-10-25(18)13-14-4-3-5-16(20)12-14/h3-9,12,18H,10-11,13H2,1-2H3 YKGFZUWYKYYZCY-UHFFFAOYSA-N 175912 US9688684, Compound 109: {4-[7-(3-Bromo-benzyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazin-8-yl]-phenyl}-dimethyl-amine Nuclear receptor ROR-gamma [238-497] 500 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175912 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175912&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169364 363892748 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473633 CN(C)c1ccc(cc1)C1N(Cc2cccc(Br)c2)CCn2nnnc12 InChI=1S/C19H21BrN6/c1-24(2)17-8-6-15(7-9-17)18-19-21-22-23-26(19)11-10-25(18)13-14-4-3-5-16(20)12-14/h3-9,12,18H,10-11,13H2,1-2H3 YKGFZUWYKYYZCY-UHFFFAOYSA-N 175912 US9688684, Compound 109: {4-[7-(3-Bromo-benzyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazin-8-yl]-phenyl}-dimethyl-amine Nuclear receptor ROR-gamma [238-497] 24950 US Patent 10.7270/Q2DB7ZZK aid1794990 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175912 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175912&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169364 363892748 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473634 CC(C)Oc1ccc(cc1)C1N(Cc2cccc(Br)c2)CCn2nnnc12 InChI=1S/C20H22BrN5O/c1-14(2)27-18-8-6-16(7-9-18)19-20-22-23-24-26(20)11-10-25(19)13-15-4-3-5-17(21)12-15/h3-9,12,14,19H,10-11,13H2,1-2H3 WBEIBCRNUAVDDW-UHFFFAOYSA-N 175913 US9688684, Compound 110: 7-(3-Bromo-benzyl)-8-(4-isopropoxy-phenyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 500 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175913 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175913&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169398 363892749 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473635 CC(C)Oc1ccc(cc1)C1N(Cc2cccc(Br)c2)CCn2nnnc12 InChI=1S/C20H22BrN5O/c1-14(2)27-18-8-6-16(7-9-18)19-20-22-23-24-26(20)11-10-25(19)13-15-4-3-5-17(21)12-15/h3-9,12,14,19H,10-11,13H2,1-2H3 WBEIBCRNUAVDDW-UHFFFAOYSA-N 175913 US9688684, Compound 110: 7-(3-Bromo-benzyl)-8-(4-isopropoxy-phenyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 5445 US Patent 10.7270/Q2DB7ZZK aid1794990 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175913 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175913&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169398 363892749 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473636 Clc1ccc(cc1)C1N(Cc2ccccc2)CCn2nnnc12 InChI=1S/C17H16ClN5/c18-15-8-6-14(7-9-15)16-17-19-20-21-23(17)11-10-22(16)12-13-4-2-1-3-5-13/h1-9,16H,10-12H2 DRVCLBMCSDUNKT-UHFFFAOYSA-N 175914 US9688684, Compound 111: 7-Benzyl-8-(4-chloro-phenyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 5445 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175914 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175914&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169552 363892750 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473637 Clc1ccc(cc1)C1N(Cc2ccccc2)CCn2nnnc12 InChI=1S/C17H16ClN5/c18-15-8-6-14(7-9-15)16-17-19-20-21-23(17)11-10-22(16)12-13-4-2-1-3-5-13/h1-9,16H,10-12H2 DRVCLBMCSDUNKT-UHFFFAOYSA-N 175914 US9688684, Compound 111: 7-Benzyl-8-(4-chloro-phenyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 24950 US Patent 10.7270/Q2DB7ZZK aid1794990 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175914 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175914&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169552 363892750 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473638 Fc1ccc(F)c(c1)C1N(Cc2ccccc2)CCn2nnnc12 InChI=1S/C17H15F2N5/c18-13-6-7-15(19)14(10-13)16-17-20-21-22-24(17)9-8-23(16)11-12-4-2-1-3-5-12/h1-7,10,16H,8-9,11H2 JAWNTGQBRRIVKU-UHFFFAOYSA-N 175915 US9688684, Compound 112: 7-Benzyl-8-(2,5-difluoro-phenyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 5445 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175915 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175915&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169423 363892751 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473639 Fc1ccc(F)c(c1)C1N(Cc2ccccc2)CCn2nnnc12 InChI=1S/C17H15F2N5/c18-13-6-7-15(19)14(10-13)16-17-20-21-22-24(17)9-8-23(16)11-12-4-2-1-3-5-12/h1-7,10,16H,8-9,11H2 JAWNTGQBRRIVKU-UHFFFAOYSA-N 175915 US9688684, Compound 112: 7-Benzyl-8-(2,5-difluoro-phenyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 24950 US Patent 10.7270/Q2DB7ZZK aid1794990 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175915 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175915&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169423 363892751 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473640 Fc1cccc(C2N(Cc3ccccc3)CCn3nnnc23)c1F InChI=1S/C17H15F2N5/c18-14-8-4-7-13(15(14)19)16-17-20-21-22-24(17)10-9-23(16)11-12-5-2-1-3-6-12/h1-8,16H,9-11H2 MYOCSUHBACMXII-UHFFFAOYSA-N 175916 US9688684, Compound 113: 7-Benzyl-8-(2,3-difluoro-phenyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 5445 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175916 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175916&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169411 363892752 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473641 Fc1cccc(C2N(Cc3ccccc3)CCn3nnnc23)c1F InChI=1S/C17H15F2N5/c18-14-8-4-7-13(15(14)19)16-17-20-21-22-24(17)10-9-23(16)11-12-5-2-1-3-6-12/h1-8,16H,9-11H2 MYOCSUHBACMXII-UHFFFAOYSA-N 175916 US9688684, Compound 113: 7-Benzyl-8-(2,3-difluoro-phenyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 24950 US Patent 10.7270/Q2DB7ZZK aid1794990 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175916 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175916&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169411 363892752 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473642 CC(C)c1nn(cc1C1N(CCn2nnnc12)C1CCCCC1)-c1ccccc1 InChI=1S/C22H29N7/c1-16(2)20-19(15-29(24-20)18-11-7-4-8-12-18)21-22-23-25-26-28(22)14-13-27(21)17-9-5-3-6-10-17/h4,7-8,11-12,15-17,21H,3,5-6,9-10,13-14H2,1-2H3 BOUIKTXHPZTBKU-UHFFFAOYSA-N 175917 US9688684, Compound 114: 7-Cyclohexyl-8-(3-isopropyl-1-phenyl-1H-pyrazol-4-yl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 5445 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175917 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175917&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169385 363892753 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473643 CC(C)c1nn(cc1C1N(CCn2nnnc12)C1CCCCC1)-c1ccccc1 InChI=1S/C22H29N7/c1-16(2)20-19(15-29(24-20)18-11-7-4-8-12-18)21-22-23-25-26-28(22)14-13-27(21)17-9-5-3-6-10-17/h4,7-8,11-12,15-17,21H,3,5-6,9-10,13-14H2,1-2H3 BOUIKTXHPZTBKU-UHFFFAOYSA-N 175917 US9688684, Compound 114: 7-Cyclohexyl-8-(3-isopropyl-1-phenyl-1H-pyrazol-4-yl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 24950 US Patent 10.7270/Q2DB7ZZK aid1794990 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175917 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175917&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169385 363892753 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473644 CCOc1ccc(cc1)C1N(Cc2cccc(Br)c2)CCn2nnnc12 InChI=1S/C19H20BrN5O/c1-2-26-17-8-6-15(7-9-17)18-19-21-22-23-25(19)11-10-24(18)13-14-4-3-5-16(20)12-14/h3-9,12,18H,2,10-11,13H2,1H3 YQZYESXYUAGTPH-UHFFFAOYSA-N 175918 US9688684, Compound 115: 7-(3-Bromo-benzyl)-8-(4-ethoxy-phenyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 5445 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175918 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175918&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169370 363892754 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473645 CCOc1ccc(cc1)C1N(Cc2cccc(Br)c2)CCn2nnnc12 InChI=1S/C19H20BrN5O/c1-2-26-17-8-6-15(7-9-17)18-19-21-22-23-25(19)11-10-24(18)13-14-4-3-5-16(20)12-14/h3-9,12,18H,2,10-11,13H2,1H3 YQZYESXYUAGTPH-UHFFFAOYSA-N 175918 US9688684, Compound 115: 7-(3-Bromo-benzyl)-8-(4-ethoxy-phenyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 5445 US Patent 10.7270/Q2DB7ZZK aid1794990 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175918 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175918&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169370 363892754 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473646 Cc1cccc(CN2CCn3nnnc3C2c2cccc(F)c2)c1 InChI=1S/C18H18FN5/c1-13-4-2-5-14(10-13)12-23-8-9-24-18(20-21-22-24)17(23)15-6-3-7-16(19)11-15/h2-7,10-11,17H,8-9,12H2,1H3 AIHHBBHPKMJQBN-UHFFFAOYSA-N 175919 US9688684, Compound 116: 8-(3-Fluoro-phenyl)-7-(3-methyl-benzyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 5445 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175919 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175919&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169404 363892755 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473647 Cc1cccc(CN2CCn3nnnc3C2c2cccc(F)c2)c1 InChI=1S/C18H18FN5/c1-13-4-2-5-14(10-13)12-23-8-9-24-18(20-21-22-24)17(23)15-6-3-7-16(19)11-15/h2-7,10-11,17H,8-9,12H2,1H3 AIHHBBHPKMJQBN-UHFFFAOYSA-N 175919 US9688684, Compound 116: 8-(3-Fluoro-phenyl)-7-(3-methyl-benzyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 5445 US Patent 10.7270/Q2DB7ZZK aid1794990 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175919 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175919&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169404 363892755 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473648 Fc1cccc(c1)C1N(Cc2cccs2)CCn2nnnc12 InChI=1S/C15H14FN5S/c16-12-4-1-3-11(9-12)14-15-17-18-19-21(15)7-6-20(14)10-13-5-2-8-22-13/h1-5,8-9,14H,6-7,10H2 XDHCGMYOFHKQIX-UHFFFAOYSA-N 175920 US9688684, Compound 117: 8-(3-Fluoro-phenyl)-7-thiophen-2-ylmethyl-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 5445 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175920 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175920&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169445 363892756 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473649 Fc1cccc(c1)C1N(Cc2cccs2)CCn2nnnc12 InChI=1S/C15H14FN5S/c16-12-4-1-3-11(9-12)14-15-17-18-19-21(15)7-6-20(14)10-13-5-2-8-22-13/h1-5,8-9,14H,6-7,10H2 XDHCGMYOFHKQIX-UHFFFAOYSA-N 175920 US9688684, Compound 117: 8-(3-Fluoro-phenyl)-7-thiophen-2-ylmethyl-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 24950 US Patent 10.7270/Q2DB7ZZK aid1794990 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175920 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175920&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169445 363892756 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473650 CCOc1ccc(cc1)C1N(Cc2cccc(C)c2)CCn2nnnc12 InChI=1S/C20H23N5O/c1-3-26-18-9-7-17(8-10-18)19-20-21-22-23-25(20)12-11-24(19)14-16-6-4-5-15(2)13-16/h4-10,13,19H,3,11-12,14H2,1-2H3 WPIFDRBKSBHDAO-UHFFFAOYSA-N 175921 US9688684, Compound 118: 8-(4-Ethoxy-phenyl)-7-(3-methyl-benzyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 5445 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175921 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175921&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169457 363892757 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473651 CCOc1ccc(cc1)C1N(Cc2cccc(C)c2)CCn2nnnc12 InChI=1S/C20H23N5O/c1-3-26-18-9-7-17(8-10-18)19-20-21-22-23-25(20)12-11-24(19)14-16-6-4-5-15(2)13-16/h4-10,13,19H,3,11-12,14H2,1-2H3 WPIFDRBKSBHDAO-UHFFFAOYSA-N 175921 US9688684, Compound 118: 8-(4-Ethoxy-phenyl)-7-(3-methyl-benzyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 24950 US Patent 10.7270/Q2DB7ZZK aid1794990 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175921 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175921&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169457 363892757 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473652 Fc1cc(Cl)ccc1C1N(Cc2cccc(Br)c2)CCn2nnnc12 InChI=1S/C17H14BrClFN5/c18-12-3-1-2-11(8-12)10-24-6-7-25-17(21-22-23-25)16(24)14-5-4-13(19)9-15(14)20/h1-5,8-9,16H,6-7,10H2 IECDIRFDGDPCQA-UHFFFAOYSA-N 175922 US9688684, Compound 119: 7-(3-Bromo-benzyl)-8-(2-fluoro-phenyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 5445 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175922 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175922&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 133081658 363892758 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473653 Fc1cc(Cl)ccc1C1N(Cc2cccc(Br)c2)CCn2nnnc12 InChI=1S/C17H14BrClFN5/c18-12-3-1-2-11(8-12)10-24-6-7-25-17(21-22-23-25)16(24)14-5-4-13(19)9-15(14)20/h1-5,8-9,16H,6-7,10H2 IECDIRFDGDPCQA-UHFFFAOYSA-N 175922 US9688684, Compound 119: 7-(3-Bromo-benzyl)-8-(2-fluoro-phenyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 5445 US Patent 10.7270/Q2DB7ZZK aid1794990 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175922 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175922&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 133081658 363892758 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473654 COc1ccc(cc1)C1N(Cc2cccc(Br)c2)CCn2nnnc12 InChI=1S/C18H18BrN5O/c1-25-16-7-5-14(6-8-16)17-18-20-21-22-24(18)10-9-23(17)12-13-3-2-4-15(19)11-13/h2-8,11,17H,9-10,12H2,1H3 YACXBFYXDFMPSR-UHFFFAOYSA-N 175923 US9688684, Compound 120: 7-(3-Bromo-benzyl)-8-(4-methoxy-phenyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 5445 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175923 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175923&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169388 363892759 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473655 COc1ccc(cc1)C1N(Cc2cccc(Br)c2)CCn2nnnc12 InChI=1S/C18H18BrN5O/c1-25-16-7-5-14(6-8-16)17-18-20-21-22-24(18)10-9-23(17)12-13-3-2-4-15(19)11-13/h2-8,11,17H,9-10,12H2,1H3 YACXBFYXDFMPSR-UHFFFAOYSA-N 175923 US9688684, Compound 120: 7-(3-Bromo-benzyl)-8-(4-methoxy-phenyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 24950 US Patent 10.7270/Q2DB7ZZK aid1794990 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175923 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175923&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169388 363892759 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473656 CC(C)Oc1ccc(cc1)C1N(Cc2cccs2)CCn2nnnc12 InChI=1S/C18H21N5OS/c1-13(2)24-15-7-5-14(6-8-15)17-18-19-20-21-23(18)10-9-22(17)12-16-4-3-11-25-16/h3-8,11,13,17H,9-10,12H2,1-2H3 ZKUDNJQBTYGPAP-UHFFFAOYSA-N 175924 US9688684, Compound 121: 8-(4-Isopropoxy-phenyl)-7-thiophen-2-ylmethyl-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 5445 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175924 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175924&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169568 363892760 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473657 CC(C)Oc1ccc(cc1)C1N(Cc2cccs2)CCn2nnnc12 InChI=1S/C18H21N5OS/c1-13(2)24-15-7-5-14(6-8-15)17-18-19-20-21-23(18)10-9-22(17)12-16-4-3-11-25-16/h3-8,11,13,17H,9-10,12H2,1-2H3 ZKUDNJQBTYGPAP-UHFFFAOYSA-N 175924 US9688684, Compound 121: 8-(4-Isopropoxy-phenyl)-7-thiophen-2-ylmethyl-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 5445 US Patent 10.7270/Q2DB7ZZK aid1794990 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175924 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175924&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169568 363892760 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473658 COc1ccc(cc1)C1N(Cc2ccccc2)CCn2nnnc12 InChI=1S/C18H19N5O/c1-24-16-9-7-15(8-10-16)17-18-19-20-21-23(18)12-11-22(17)13-14-5-3-2-4-6-14/h2-10,17H,11-13H2,1H3 QENQBYMAHGGKEP-UHFFFAOYSA-N 175925 US9688684, Compound 122: 7-Benzyl-8-(4-methoxy-phenyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 5445 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175925 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175925&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 102074075 363892761 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473659 COc1ccc(cc1)C1N(Cc2ccccc2)CCn2nnnc12 InChI=1S/C18H19N5O/c1-24-16-9-7-15(8-10-16)17-18-19-20-21-23(18)12-11-22(17)13-14-5-3-2-4-6-14/h2-10,17H,11-13H2,1H3 QENQBYMAHGGKEP-UHFFFAOYSA-N 175925 US9688684, Compound 122: 7-Benzyl-8-(4-methoxy-phenyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 24950 US Patent 10.7270/Q2DB7ZZK aid1794990 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175925 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175925&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 102074075 363892761 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473660 Brc1cccc(CN2CCn3nnnc3C2c2ccccc2)c1 InChI=1S/C17H16BrN5/c18-15-8-4-5-13(11-15)12-22-9-10-23-17(19-20-21-23)16(22)14-6-2-1-3-7-14/h1-8,11,16H,9-10,12H2 OKUVZDLAKMBWGN-UHFFFAOYSA-N 175926 US9688684, Compound 123: 7-(3-Bromo-benzyl)-8-phenyl-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 5445 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175926 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175926&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169511 363892762 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473661 Brc1cccc(CN2CCn3nnnc3C2c2ccccc2)c1 InChI=1S/C17H16BrN5/c18-15-8-4-5-13(11-15)12-22-9-10-23-17(19-20-21-23)16(22)14-6-2-1-3-7-14/h1-8,11,16H,9-10,12H2 OKUVZDLAKMBWGN-UHFFFAOYSA-N 175926 US9688684, Compound 123: 7-(3-Bromo-benzyl)-8-phenyl-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 24950 US Patent 10.7270/Q2DB7ZZK aid1794990 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175926 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175926&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169511 363892762 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473662 Fc1cc(F)cc(c1)C1N(Cc2cccs2)CCn2nnnc12 InChI=1S/C15H13F2N5S/c16-11-6-10(7-12(17)8-11)14-15-18-19-20-22(15)4-3-21(14)9-13-2-1-5-23-13/h1-2,5-8,14H,3-4,9H2 QXPPFEBHDVRAOA-UHFFFAOYSA-N 175927 US9688684, Compound 124: 8-(3,5-Difluoro-phenyl)-7-thiophen-2-ylmethyl-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 5445 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175927 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175927&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169557 363892763 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473663 Fc1cc(F)cc(c1)C1N(Cc2cccs2)CCn2nnnc12 InChI=1S/C15H13F2N5S/c16-11-6-10(7-12(17)8-11)14-15-18-19-20-22(15)4-3-21(14)9-13-2-1-5-23-13/h1-2,5-8,14H,3-4,9H2 QXPPFEBHDVRAOA-UHFFFAOYSA-N 175927 US9688684, Compound 124: 8-(3,5-Difluoro-phenyl)-7-thiophen-2-ylmethyl-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 24950 US Patent 10.7270/Q2DB7ZZK aid1794990 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175927 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175927&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169557 363892763 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473664 Fc1ccc(cc1)C1N(Cc2cccs2)CCn2nnnc12 InChI=1S/C15H14FN5S/c16-12-5-3-11(4-6-12)14-15-17-18-19-21(15)8-7-20(14)10-13-2-1-9-22-13/h1-6,9,14H,7-8,10H2 OFILHZZSMPYPGP-UHFFFAOYSA-N 175928 US9688684, Compound 125: 8-(4-Fluoro-phenyl)-7-thiophen-2-ylmethyl-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 5445 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175928 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175928&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169419 363892764 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473665 Fc1ccc(cc1)C1N(Cc2cccs2)CCn2nnnc12 InChI=1S/C15H14FN5S/c16-12-5-3-11(4-6-12)14-15-17-18-19-21(15)8-7-20(14)10-13-2-1-9-22-13/h1-6,9,14H,7-8,10H2 OFILHZZSMPYPGP-UHFFFAOYSA-N 175928 US9688684, Compound 125: 8-(4-Fluoro-phenyl)-7-thiophen-2-ylmethyl-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 24950 US Patent 10.7270/Q2DB7ZZK aid1794990 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175928 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175928&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169419 363892764 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473666 CN(C)c1ccc(cc1)C1N(Cc2ccc(F)cc2)CCn2nnnc12 InChI=1S/C19H21FN6/c1-24(2)17-9-5-15(6-10-17)18-19-21-22-23-26(19)12-11-25(18)13-14-3-7-16(20)8-4-14/h3-10,18H,11-13H2,1-2H3 YDMNEQJGFHVWPF-UHFFFAOYSA-N 175929 US9688684, Compound 126: {4-[7-(4-Fluoro-benzyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazin-8-yl]-phenyl}-dimethyl-amine Nuclear receptor ROR-gamma [238-497] 5445 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175929 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175929&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169513 363892765 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473667 CN(C)c1ccc(cc1)C1N(Cc2ccc(F)cc2)CCn2nnnc12 InChI=1S/C19H21FN6/c1-24(2)17-9-5-15(6-10-17)18-19-21-22-23-26(19)12-11-25(18)13-14-3-7-16(20)8-4-14/h3-10,18H,11-13H2,1-2H3 YDMNEQJGFHVWPF-UHFFFAOYSA-N 175929 US9688684, Compound 126: {4-[7-(4-Fluoro-benzyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazin-8-yl]-phenyl}-dimethyl-amine Nuclear receptor ROR-gamma [238-497] 24950 US Patent 10.7270/Q2DB7ZZK aid1794990 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175929 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175929&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169513 363892765 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473668 C(N1CCn2nnnc2C1c1ccccc1)c1ccccc1 InChI=1S/C17H17N5/c1-3-7-14(8-4-1)13-21-11-12-22-17(18-19-20-22)16(21)15-9-5-2-6-10-15/h1-10,16H,11-13H2 MPHQLYYYSCXLOI-UHFFFAOYSA-N 175930 US9688684, Compound 127: 7-Benzyl-8-phenyl-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 5445 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175930 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175930&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169424 363892766 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473669 C(N1CCn2nnnc2C1c1ccccc1)c1ccccc1 InChI=1S/C17H17N5/c1-3-7-14(8-4-1)13-21-11-12-22-17(18-19-20-22)16(21)15-9-5-2-6-10-15/h1-10,16H,11-13H2 MPHQLYYYSCXLOI-UHFFFAOYSA-N 175930 US9688684, Compound 127: 7-Benzyl-8-phenyl-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 24950 US Patent 10.7270/Q2DB7ZZK aid1794990 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175930 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175930&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169424 363892766 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473670 COc1ccc(OC)c(c1)C1N(Cc2ccc(F)cc2)CCn2nnnc12 InChI=1S/C19H20FN5O2/c1-26-15-7-8-17(27-2)16(11-15)18-19-21-22-23-25(19)10-9-24(18)12-13-3-5-14(20)6-4-13/h3-8,11,18H,9-10,12H2,1-2H3 CCUCGDBSHATMJL-UHFFFAOYSA-N 175931 US9688684, Compound 128: 8-(2,5-Dimethoxy-phenyl)-7-(4-fluoro-benzyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 5445 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175931 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175931&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169369 363892767 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473671 COc1ccc(OC)c(c1)C1N(Cc2ccc(F)cc2)CCn2nnnc12 InChI=1S/C19H20FN5O2/c1-26-15-7-8-17(27-2)16(11-15)18-19-21-22-23-25(19)10-9-24(18)12-13-3-5-14(20)6-4-13/h3-8,11,18H,9-10,12H2,1-2H3 CCUCGDBSHATMJL-UHFFFAOYSA-N 175931 US9688684, Compound 128: 8-(2,5-Dimethoxy-phenyl)-7-(4-fluoro-benzyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 24950 US Patent 10.7270/Q2DB7ZZK aid1794990 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175931 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175931&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169369 363892767 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473672 CN(C)c1ccc(cc1)C1N(Cc2cccc(C)c2)CCn2nnnc12 InChI=1S/C20H24N6/c1-15-5-4-6-16(13-15)14-25-11-12-26-20(21-22-23-26)19(25)17-7-9-18(10-8-17)24(2)3/h4-10,13,19H,11-12,14H2,1-3H3 UUGDQLBYPQMMKQ-UHFFFAOYSA-N 175932 US9688684, Compound 129: Dimethyl-{4-[7-(3-methyl-benzyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazin-8-yl]-phenyl}-amine Nuclear receptor ROR-gamma [238-497] 5445 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175932 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175932&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169473 363892768 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473673 CN(C)c1ccc(cc1)C1N(Cc2cccc(C)c2)CCn2nnnc12 InChI=1S/C20H24N6/c1-15-5-4-6-16(13-15)14-25-11-12-26-20(21-22-23-26)19(25)17-7-9-18(10-8-17)24(2)3/h4-10,13,19H,11-12,14H2,1-3H3 UUGDQLBYPQMMKQ-UHFFFAOYSA-N 175932 US9688684, Compound 129: Dimethyl-{4-[7-(3-methyl-benzyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazin-8-yl]-phenyl}-amine Nuclear receptor ROR-gamma [238-497] 24950 US Patent 10.7270/Q2DB7ZZK aid1794990 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175932 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175932&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169473 363892768 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473674 CCCCOc1ccc(cc1)C1N(Cc2ccccc2F)CCn2nnnc12 InChI=1S/C21H24FN5O/c1-2-3-14-28-18-10-8-16(9-11-18)20-21-23-24-25-27(21)13-12-26(20)15-17-6-4-5-7-19(17)22/h4-11,20H,2-3,12-15H2,1H3 VCNNRJQABHSKQD-UHFFFAOYSA-N 175933 US9688684, Compound 130: 8-(4-Butoxy-phenyl)-7-(2-fluoro-benzyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 5445 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175933 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175933&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169442 363892769 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473675 CCCCOc1ccc(cc1)C1N(Cc2ccccc2F)CCn2nnnc12 InChI=1S/C21H24FN5O/c1-2-3-14-28-18-10-8-16(9-11-18)20-21-23-24-25-27(21)13-12-26(20)15-17-6-4-5-7-19(17)22/h4-11,20H,2-3,12-15H2,1H3 VCNNRJQABHSKQD-UHFFFAOYSA-N 175933 US9688684, Compound 130: 8-(4-Butoxy-phenyl)-7-(2-fluoro-benzyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 5445 US Patent 10.7270/Q2DB7ZZK aid1794990 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175933 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175933&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169442 363892769 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473676 CC(C)Oc1ccc(cc1)C1N(Cc2ccc3OCOc3c2)CCn2nnnc12 InChI=1S/C21H23N5O3/c1-14(2)29-17-6-4-16(5-7-17)20-21-22-23-24-26(21)10-9-25(20)12-15-3-8-18-19(11-15)28-13-27-18/h3-8,11,14,20H,9-10,12-13H2,1-2H3 LYSDUBUZXCQBOV-UHFFFAOYSA-N 175934 US9688684, Compound 131: 7-Benzo[1,3]dioxol-5-ylmethyl-8-(4-isopropoxy-phenyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 5445 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175934 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175934&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169372 363892770 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473677 CC(C)Oc1ccc(cc1)C1N(Cc2ccc3OCOc3c2)CCn2nnnc12 InChI=1S/C21H23N5O3/c1-14(2)29-17-6-4-16(5-7-17)20-21-22-23-24-26(21)10-9-25(20)12-15-3-8-18-19(11-15)28-13-27-18/h3-8,11,14,20H,9-10,12-13H2,1-2H3 LYSDUBUZXCQBOV-UHFFFAOYSA-N 175934 US9688684, Compound 131: 7-Benzo[1,3]dioxol-5-ylmethyl-8-(4-isopropoxy-phenyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 24950 US Patent 10.7270/Q2DB7ZZK aid1794990 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175934 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175934&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169372 363892770 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473678 CC(C)Oc1ccc(cc1)C1N(Cc2ccc(F)cc2)CCn2nnnc12 InChI=1S/C20H22FN5O/c1-14(2)27-18-9-5-16(6-10-18)19-20-22-23-24-26(20)12-11-25(19)13-15-3-7-17(21)8-4-15/h3-10,14,19H,11-13H2,1-2H3 SISMUWDKAODVTB-UHFFFAOYSA-N 175935 US9688684, Compound 132: 7-(4-Fluoro-benzyl)-8-(4-isopropoxy-phenyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 5445 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175935 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175935&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169393 363892771 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473679 CC(C)Oc1ccc(cc1)C1N(Cc2ccc(F)cc2)CCn2nnnc12 InChI=1S/C20H22FN5O/c1-14(2)27-18-9-5-16(6-10-18)19-20-22-23-24-26(20)12-11-25(19)13-15-3-7-17(21)8-4-15/h3-10,14,19H,11-13H2,1-2H3 SISMUWDKAODVTB-UHFFFAOYSA-N 175935 US9688684, Compound 132: 7-(4-Fluoro-benzyl)-8-(4-isopropoxy-phenyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 24950 US Patent 10.7270/Q2DB7ZZK aid1794990 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175935 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175935&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169393 363892771 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473680 Fc1ccc(CN2CCn3nnnc3C2c2ccc3OCCOc3c2)cc1 InChI=1S/C19H18FN5O2/c20-15-4-1-13(2-5-15)12-24-7-8-25-19(21-22-23-25)18(24)14-3-6-16-17(11-14)27-10-9-26-16/h1-6,11,18H,7-10,12H2 YWVRDLRDNORVKR-UHFFFAOYSA-N 175936 US9688684, Compound 133: 8-(2,3-Dihydro-benzo[1,4]dioxin-6-yl)-7-(4-fluoro-benzyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 5445 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175936 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175936&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169439 363892772 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473681 Fc1ccc(CN2CCn3nnnc3C2c2ccc3OCCOc3c2)cc1 InChI=1S/C19H18FN5O2/c20-15-4-1-13(2-5-15)12-24-7-8-25-19(21-22-23-25)18(24)14-3-6-16-17(11-14)27-10-9-26-16/h1-6,11,18H,7-10,12H2 YWVRDLRDNORVKR-UHFFFAOYSA-N 175936 US9688684, Compound 133: 8-(2,3-Dihydro-benzo[1,4]dioxin-6-yl)-7-(4-fluoro-benzyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 24950 US Patent 10.7270/Q2DB7ZZK aid1794990 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175936 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175936&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169439 363892772 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473682 CCOc1ccc(cc1)C1N(Cc2ccc(F)cc2)CCn2nnnc12 InChI=1S/C19H20FN5O/c1-2-26-17-9-5-15(6-10-17)18-19-21-22-23-25(19)12-11-24(18)13-14-3-7-16(20)8-4-14/h3-10,18H,2,11-13H2,1H3 FZQHFHJOXXHRMM-UHFFFAOYSA-N 175937 US9688684, Compound 134: 8-(4-Ethoxy-phenyl)-7-(4-fluoro-benzyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 5445 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175937 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175937&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169401 363892773 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473683 CCOc1ccc(cc1)C1N(Cc2ccc(F)cc2)CCn2nnnc12 InChI=1S/C19H20FN5O/c1-2-26-17-9-5-15(6-10-17)18-19-21-22-23-25(19)12-11-24(18)13-14-3-7-16(20)8-4-14/h3-10,18H,2,11-13H2,1H3 FZQHFHJOXXHRMM-UHFFFAOYSA-N 175937 US9688684, Compound 134: 8-(4-Ethoxy-phenyl)-7-(4-fluoro-benzyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 24950 US Patent 10.7270/Q2DB7ZZK aid1794990 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175937 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175937&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169401 363892773 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473684 COc1ccc(OC)c(c1)C1N(Cc2ccccc2)CCn2nnnc12 InChI=1S/C19H21N5O2/c1-25-15-8-9-17(26-2)16(12-15)18-19-20-21-22-24(19)11-10-23(18)13-14-6-4-3-5-7-14/h3-9,12,18H,10-11,13H2,1-2H3 UDRMVNRXSCZXSG-UHFFFAOYSA-N 175938 US9688684, Compound 135: 7-Benzyl-8-(2,5-dimethoxy-phenyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 5445 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175938 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175938&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169482 363892774 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473685 COc1ccc(OC)c(c1)C1N(Cc2ccccc2)CCn2nnnc12 InChI=1S/C19H21N5O2/c1-25-15-8-9-17(26-2)16(12-15)18-19-20-21-22-24(19)11-10-23(18)13-14-6-4-3-5-7-14/h3-9,12,18H,10-11,13H2,1-2H3 UDRMVNRXSCZXSG-UHFFFAOYSA-N 175938 US9688684, Compound 135: 7-Benzyl-8-(2,5-dimethoxy-phenyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 24950 US Patent 10.7270/Q2DB7ZZK aid1794990 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175938 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175938&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169482 363892774 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473686 Cc1cccc(CN2CCn3nnnc3C2c2ccc(F)cc2F)c1 InChI=1S/C18H17F2N5/c1-12-3-2-4-13(9-12)11-24-7-8-25-18(21-22-23-25)17(24)15-6-5-14(19)10-16(15)20/h2-6,9-10,17H,7-8,11H2,1H3 RIZVLRHNXAVZGD-UHFFFAOYSA-N 175939 US9688684, Compound 136: 8-(2,4-Difluoro-phenyl)-7-(3-methyl-benzyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 5445 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175939 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175939&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169399 363892775 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473687 Cc1cccc(CN2CCn3nnnc3C2c2ccc(F)cc2F)c1 InChI=1S/C18H17F2N5/c1-12-3-2-4-13(9-12)11-24-7-8-25-18(21-22-23-25)17(24)15-6-5-14(19)10-16(15)20/h2-6,9-10,17H,7-8,11H2,1H3 RIZVLRHNXAVZGD-UHFFFAOYSA-N 175939 US9688684, Compound 136: 8-(2,4-Difluoro-phenyl)-7-(3-methyl-benzyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 24950 US Patent 10.7270/Q2DB7ZZK aid1794990 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175939 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175939&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169399 363892775 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473688 Fc1ccccc1C1N(Cc2cccs2)CCn2nnnc12 InChI=1S/C15H14FN5S/c16-13-6-2-1-5-12(13)14-15-17-18-19-21(15)8-7-20(14)10-11-4-3-9-22-11/h1-6,9,14H,7-8,10H2 YFZREWMURQUINS-UHFFFAOYSA-N 175940 US9688684, Compound 137: 8-(2-Fluoro-phenyl)-7-thiophen-2-ylmethyl-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 5445 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175940 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175940&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169539 363892776 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473689 Fc1ccccc1C1N(Cc2cccs2)CCn2nnnc12 InChI=1S/C15H14FN5S/c16-13-6-2-1-5-12(13)14-15-17-18-19-21(15)8-7-20(14)10-11-4-3-9-22-11/h1-6,9,14H,7-8,10H2 YFZREWMURQUINS-UHFFFAOYSA-N 175940 US9688684, Compound 137: 8-(2-Fluoro-phenyl)-7-thiophen-2-ylmethyl-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 24950 US Patent 10.7270/Q2DB7ZZK aid1794990 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175940 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175940&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169539 363892776 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473690 Fc1ccccc1CN1CCn2nnnc2C1c1ccc(Cl)cc1 InChI=1S/C17H15ClFN5/c18-14-7-5-12(6-8-14)16-17-20-21-22-24(17)10-9-23(16)11-13-3-1-2-4-15(13)19/h1-8,16H,9-11H2 YHNWIMGKEKCEJH-UHFFFAOYSA-N 175941 US9688684, Compound 138: 8-(4-Chloro-phenyl)-7-(2-fluoro-benzyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 5445 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175941 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175941&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169408 363892777 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473691 Fc1ccccc1CN1CCn2nnnc2C1c1ccc(Cl)cc1 InChI=1S/C17H15ClFN5/c18-14-7-5-12(6-8-14)16-17-20-21-22-24(17)10-9-23(16)11-13-3-1-2-4-15(13)19/h1-8,16H,9-11H2 YHNWIMGKEKCEJH-UHFFFAOYSA-N 175941 US9688684, Compound 138: 8-(4-Chloro-phenyl)-7-(2-fluoro-benzyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 24950 US Patent 10.7270/Q2DB7ZZK aid1794990 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175941 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175941&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169408 363892777 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473692 C(N1CCn2nnnc2C1c1ccccc1)c1cccs1 InChI=1S/C15H15N5S/c1-2-5-12(6-3-1)14-15-16-17-18-20(15)9-8-19(14)11-13-7-4-10-21-13/h1-7,10,14H,8-9,11H2 DJOKSTNFQCZZCJ-UHFFFAOYSA-N 175942 US9688684, Compound 139: 8-Phenyl-7-thiophen-2-ylmethyl-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 5445 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175942 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175942&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169518 363892778 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473693 C(N1CCn2nnnc2C1c1ccccc1)c1cccs1 InChI=1S/C15H15N5S/c1-2-5-12(6-3-1)14-15-16-17-18-20(15)9-8-19(14)11-13-7-4-10-21-13/h1-7,10,14H,8-9,11H2 DJOKSTNFQCZZCJ-UHFFFAOYSA-N 175942 US9688684, Compound 139: 8-Phenyl-7-thiophen-2-ylmethyl-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 24950 US Patent 10.7270/Q2DB7ZZK aid1794990 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175942 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175942&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169518 363892778 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473694 Fc1ccc(F)c(c1)C1N(Cc2cccs2)CCn2nnnc12 InChI=1S/C15H13F2N5S/c16-10-3-4-13(17)12(8-10)14-15-18-19-20-22(15)6-5-21(14)9-11-2-1-7-23-11/h1-4,7-8,14H,5-6,9H2 HYYWLKFIQPFBKR-UHFFFAOYSA-N 175943 US9688684, Compound 140: 8-(2,5-Difluoro-phenyl)-7-thiophen-2-ylmethyl-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 24950 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175943 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175943&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169357 363892779 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473695 Fc1ccc(F)c(c1)C1N(Cc2cccs2)CCn2nnnc12 InChI=1S/C15H13F2N5S/c16-10-3-4-13(17)12(8-10)14-15-18-19-20-22(15)6-5-21(14)9-11-2-1-7-23-11/h1-4,7-8,14H,5-6,9H2 HYYWLKFIQPFBKR-UHFFFAOYSA-N 175943 US9688684, Compound 140: 8-(2,5-Difluoro-phenyl)-7-thiophen-2-ylmethyl-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 24950 US Patent 10.7270/Q2DB7ZZK aid1794990 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175943 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175943&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169357 363892779 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473696 COc1ccc(OC)c(c1)C1N(Cc2ccccc2F)CCn2nnnc12 InChI=1S/C19H20FN5O2/c1-26-14-7-8-17(27-2)15(11-14)18-19-21-22-23-25(19)10-9-24(18)12-13-5-3-4-6-16(13)20/h3-8,11,18H,9-10,12H2,1-2H3 NSRGITMVFIFXMT-UHFFFAOYSA-N 175944 US9688684, Compound 141: 8-(2,5-Dimethoxy-phenyl)-7-(2-fluoro-benzyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 24950 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175944 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175944&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169556 363892780 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473697 COc1ccc(OC)c(c1)C1N(Cc2ccccc2F)CCn2nnnc12 InChI=1S/C19H20FN5O2/c1-26-14-7-8-17(27-2)15(11-14)18-19-21-22-23-25(19)10-9-24(18)12-13-5-3-4-6-16(13)20/h3-8,11,18H,9-10,12H2,1-2H3 NSRGITMVFIFXMT-UHFFFAOYSA-N 175944 US9688684, Compound 141: 8-(2,5-Dimethoxy-phenyl)-7-(2-fluoro-benzyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 24950 US Patent 10.7270/Q2DB7ZZK aid1794990 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175944 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175944&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169556 363892780 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473698 CC(C)Oc1ccc(cc1)C1N(Cc2ccc(C)o2)CCn2nnnc12 InChI=1S/C19H23N5O2/c1-13(2)25-16-8-5-15(6-9-16)18-19-20-21-22-24(19)11-10-23(18)12-17-7-4-14(3)26-17/h4-9,13,18H,10-12H2,1-3H3 JDXPTUYCQABJRJ-UHFFFAOYSA-N 175945 US9688684, Compound 142: 8-(4-Isopropoxy-phenyl)-7-(5-methyl-furan-2-ylmethyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 24950 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175945 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175945&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169605 363892781 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473699 CC(C)Oc1ccc(cc1)C1N(Cc2ccc(C)o2)CCn2nnnc12 InChI=1S/C19H23N5O2/c1-13(2)25-16-8-5-15(6-9-16)18-19-20-21-22-24(19)11-10-23(18)12-17-7-4-14(3)26-17/h4-9,13,18H,10-12H2,1-3H3 JDXPTUYCQABJRJ-UHFFFAOYSA-N 175945 US9688684, Compound 142: 8-(4-Isopropoxy-phenyl)-7-(5-methyl-furan-2-ylmethyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 24950 US Patent 10.7270/Q2DB7ZZK aid1794990 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175945 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175945&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169605 363892781 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473700 CC(C)c1nn(cc1C1N(Cc2cccc(Cl)c2)CCn2nnnc12)-c1ccccc1 InChI=1S/C23H24ClN7/c1-16(2)21-20(15-31(26-21)19-9-4-3-5-10-19)22-23-25-27-28-30(23)12-11-29(22)14-17-7-6-8-18(24)13-17/h3-10,13,15-16,22H,11-12,14H2,1-2H3 WUUHCECRQWTXLD-UHFFFAOYSA-N 175946 US9688684, Compound 143: 7-(3-Chloro-benzyl)-8-(3-isopropyl-1-phenyl-1H-pyrazol-4-yl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 500 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175946 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175946&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169365 363892782 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473701 CC(C)c1nn(cc1C1N(Cc2cccc(Cl)c2)CCn2nnnc12)-c1ccccc1 InChI=1S/C23H24ClN7/c1-16(2)21-20(15-31(26-21)19-9-4-3-5-10-19)22-23-25-27-28-30(23)12-11-29(22)14-17-7-6-8-18(24)13-17/h3-10,13,15-16,22H,11-12,14H2,1-2H3 WUUHCECRQWTXLD-UHFFFAOYSA-N 175946 US9688684, Compound 143: 7-(3-Chloro-benzyl)-8-(3-isopropyl-1-phenyl-1H-pyrazol-4-yl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 500 US Patent 10.7270/Q2DB7ZZK aid1794990 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175946 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175946&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169365 363892782 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473702 CCn1cc(C2N(Cc3cccs3)CCn3nnnc23)c(n1)C1CC1 InChI=1S/C17H21N7S/c1-2-23-11-14(15(19-23)12-5-6-12)16-17-18-20-21-24(17)8-7-22(16)10-13-4-3-9-25-13/h3-4,9,11-12,16H,2,5-8,10H2,1H3 GOIXMTXYMZQZGB-UHFFFAOYSA-N 175947 US9688684, Compound 144: 8-(3-Cyclopropyl-1-ethyl-1H-pyrazol-4-yl)-7-thiophen-2-ylmethyl-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 5445 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175947 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175947&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169494 363892783 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473703 CCn1cc(C2N(Cc3cccs3)CCn3nnnc23)c(n1)C1CC1 InChI=1S/C17H21N7S/c1-2-23-11-14(15(19-23)12-5-6-12)16-17-18-20-21-24(17)8-7-22(16)10-13-4-3-9-25-13/h3-4,9,11-12,16H,2,5-8,10H2,1H3 GOIXMTXYMZQZGB-UHFFFAOYSA-N 175947 US9688684, Compound 144: 8-(3-Cyclopropyl-1-ethyl-1H-pyrazol-4-yl)-7-thiophen-2-ylmethyl-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 24950 US Patent 10.7270/Q2DB7ZZK aid1794990 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175947 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175947&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169494 363892783 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473704 CC(C)c1nn(C)cc1C1N(Cc2cccs2)CCn2nnnc12 InChI=1S/C16H21N7S/c1-11(2)14-13(10-21(3)18-14)15-16-17-19-20-23(16)7-6-22(15)9-12-5-4-8-24-12/h4-5,8,10-11,15H,6-7,9H2,1-3H3 YWOHVSMRZNICCB-UHFFFAOYSA-N 175948 US9688684, Compound 145: 8-(3-Isopropyl-1-methyl-1H-pyrazol-4-yl)-7-thiophen-2-ylmethyl-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 5445 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175948 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175948&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169471 363892784 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473705 CC(C)c1nn(C)cc1C1N(Cc2cccs2)CCn2nnnc12 InChI=1S/C16H21N7S/c1-11(2)14-13(10-21(3)18-14)15-16-17-19-20-23(16)7-6-22(15)9-12-5-4-8-24-12/h4-5,8,10-11,15H,6-7,9H2,1-3H3 YWOHVSMRZNICCB-UHFFFAOYSA-N 175948 US9688684, Compound 145: 8-(3-Isopropyl-1-methyl-1H-pyrazol-4-yl)-7-thiophen-2-ylmethyl-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 24950 US Patent 10.7270/Q2DB7ZZK aid1794990 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175948 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175948&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169471 363892784 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473706 COc1ccc(cc1)C1N(Cc2ccc(F)cc2)CCn2nnnc12 InChI=1S/C18H18FN5O/c1-25-16-8-4-14(5-9-16)17-18-20-21-22-24(18)11-10-23(17)12-13-2-6-15(19)7-3-13/h2-9,17H,10-12H2,1H3 NTEDLFDYVQVNGO-UHFFFAOYSA-N 175949 US9688684, Compound 146: 7-(4-Fluoro-benzyl)-8-(4-methoxy-phenyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 24950 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175949 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175949&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169440 363892785 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473707 COc1ccc(cc1)C1N(Cc2ccc(F)cc2)CCn2nnnc12 InChI=1S/C18H18FN5O/c1-25-16-8-4-14(5-9-16)17-18-20-21-22-24(18)11-10-23(17)12-13-2-6-15(19)7-3-13/h2-9,17H,10-12H2,1H3 NTEDLFDYVQVNGO-UHFFFAOYSA-N 175949 US9688684, Compound 146: 7-(4-Fluoro-benzyl)-8-(4-methoxy-phenyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 5445 US Patent 10.7270/Q2DB7ZZK aid1794990 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175949 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175949&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169440 363892785 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473708 COc1ccc(cc1)C1N(Cc2cccc(OC)c2)CCn2nnnc12 InChI=1S/C19H21N5O2/c1-25-16-8-6-15(7-9-16)18-19-20-21-22-24(19)11-10-23(18)13-14-4-3-5-17(12-14)26-2/h3-9,12,18H,10-11,13H2,1-2H3 ILVLYCDYZYZQTL-UHFFFAOYSA-N 175950 US9688684, Compound 147: 7-(3-Methoxy-benzyl)-8-(4-methoxy-phenyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 24950 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175950 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175950&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169522 363892786 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473709 CC(C)c1nn(cc1C1N(Cc2ccc(Cl)cc2)CCn2nnnc12)-c1ccccc1 InChI=1S/C23H24ClN7/c1-16(2)21-20(15-31(26-21)19-6-4-3-5-7-19)22-23-25-27-28-30(23)13-12-29(22)14-17-8-10-18(24)11-9-17/h3-11,15-16,22H,12-14H2,1-2H3 HKRYVOSSRUGMNU-UHFFFAOYSA-N 175951 US9688684, Compound 148: 7-(4-Chloro-benzyl)-8-(3-isopropyl-1-phenyl-1H-pyrazol-4-yl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 24950 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175951 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175951&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169453 363892787 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473710 CC(C)c1nn(cc1C1N(Cc2ccc(Cl)cc2)CCn2nnnc12)-c1ccccc1 InChI=1S/C23H24ClN7/c1-16(2)21-20(15-31(26-21)19-6-4-3-5-7-19)22-23-25-27-28-30(23)13-12-29(22)14-17-8-10-18(24)11-9-17/h3-11,15-16,22H,12-14H2,1-2H3 HKRYVOSSRUGMNU-UHFFFAOYSA-N 175951 US9688684, Compound 148: 7-(4-Chloro-benzyl)-8-(3-isopropyl-1-phenyl-1H-pyrazol-4-yl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 5445 US Patent 10.7270/Q2DB7ZZK aid1794990 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175951 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175951&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169453 363892787 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473711 CC(C)Oc1ccc(CN2CCn3nnnc3C2c2ccc(cc2)N(C)C)cc1 InChI=1S/C22H28N6O/c1-16(2)29-20-11-5-17(6-12-20)15-27-13-14-28-22(23-24-25-28)21(27)18-7-9-19(10-8-18)26(3)4/h5-12,16,21H,13-15H2,1-4H3 UPFYOZJFRXXRFY-UHFFFAOYSA-N 175952 US9688684, Compound 149: {4-[7-(4-Isopropoxy-benzyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazin-8-yl]-phenyl}-dimethyl-amine Nuclear receptor ROR-gamma [238-497] 24950 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175952 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175952&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169450 363892788 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473712 CC(C)c1nn(cc1C1N(Cc2ccccc2)CCn2nnnc12)-c1ccccc1 InChI=1S/C23H25N7/c1-17(2)21-20(16-30(25-21)19-11-7-4-8-12-19)22-23-24-26-27-29(23)14-13-28(22)15-18-9-5-3-6-10-18/h3-12,16-17,22H,13-15H2,1-2H3 GRJFBGCDAFRCGJ-UHFFFAOYSA-N 175953 US9688684, Compound 150: 7-Benzyl-8-(3-isopropyl-1-phenyl-1H-pyrazol-4-yl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 24950 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175953 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175953&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169512 363892789 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473713 CC(C)c1nn(cc1C1N(Cc2ccccc2)CCn2nnnc12)-c1ccccc1 InChI=1S/C23H25N7/c1-17(2)21-20(16-30(25-21)19-11-7-4-8-12-19)22-23-24-26-27-29(23)14-13-28(22)15-18-9-5-3-6-10-18/h3-12,16-17,22H,13-15H2,1-2H3 GRJFBGCDAFRCGJ-UHFFFAOYSA-N 175953 US9688684, Compound 150: 7-Benzyl-8-(3-isopropyl-1-phenyl-1H-pyrazol-4-yl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 500 US Patent 10.7270/Q2DB7ZZK aid1794990 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175953 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175953&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169512 363892789 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473714 COc1ccc(OC)c(c1)C1N(Cc2cccc(F)c2F)CCn2nnnc12 InChI=1S/C19H19F2N5O2/c1-27-13-6-7-16(28-2)14(10-13)18-19-22-23-24-26(19)9-8-25(18)11-12-4-3-5-15(20)17(12)21/h3-7,10,18H,8-9,11H2,1-2H3 UTPKHHMYXKQOMZ-UHFFFAOYSA-N 175954 US9688684, Compound 151: 7-(2,3-Difluoro-benzyl)-8-(2,5-dimethoxy-phenyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 24950 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175954 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175954&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169387 363892790 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473715 CCc1nn(cc1C1N(Cc2ccccc2)CCn2nnnc12)-c1ccccc1 InChI=1S/C22H23N7/c1-2-20-19(16-29(24-20)18-11-7-4-8-12-18)21-22-23-25-26-28(22)14-13-27(21)15-17-9-5-3-6-10-17/h3-12,16,21H,2,13-15H2,1H3 HZJNHBMDTKSEQM-UHFFFAOYSA-N 175955 US9688684, Compound 152: 7-Benzyl-8-(4-ethyl-phenyl-1H-pyrazol-4-yl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 24950 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175955 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175955&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 133081659 363892791 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473716 CC(C)c1nn(cc1C1N(Cc2ccn[nH]2)CCn2nnnc12)-c1ccccc1 175956 US9688684, Compound 153: 8-(3-Isopropyl-1-phenyl-1H-pyrazol-4-yl)-7-(2H-pyrazol-3-ylmethyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 24950 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175956 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175956&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169597 363892792 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473717 CC(C)c1nn(cc1C1N(CC2=CNN3C=CC=CC23)CCn2nnnc12)-c1ccccc1 InChI=1S/C24H27N9/c1-17(2)22-20(16-33(27-22)19-8-4-3-5-9-19)23-24-26-28-29-32(24)13-12-30(23)15-18-14-25-31-11-7-6-10-21(18)31/h3-11,14,16-17,21,23,25H,12-13,15H2,1-2H3 ZUFHJRUAVRCEPO-UHFFFAOYSA-N 175957 US9688684, Compound 154: 8-(3-Isopropyl-1-phenyl-1H-pyrazol-4-yl)-7-pyrazolo[1,5-a]pyridin-3-ylmethyl-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 24950 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175957 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175957&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 133081660 363892793 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473718 CC(C)c1nn(cc1C1N(CC2=CNN3C=CC=CC23)CCn2nnnc12)-c1ccccc1 InChI=1S/C24H27N9/c1-17(2)22-20(16-33(27-22)19-8-4-3-5-9-19)23-24-26-28-29-32(24)13-12-30(23)15-18-14-25-31-11-7-6-10-21(18)31/h3-11,14,16-17,21,23,25H,12-13,15H2,1-2H3 ZUFHJRUAVRCEPO-UHFFFAOYSA-N 175957 US9688684, Compound 154: 8-(3-Isopropyl-1-phenyl-1H-pyrazol-4-yl)-7-pyrazolo[1,5-a]pyridin-3-ylmethyl-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 5445 US Patent 10.7270/Q2DB7ZZK aid1794990 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175957 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175957&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 133081660 363892793 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473719 CCn1cc(CN2CCn3nnnc3C2c2cn(nc2C(C)C)-c2ccccc2)cn1 InChI=1S/C22H27N9/c1-4-29-14-17(12-23-29)13-28-10-11-30-22(24-26-27-30)21(28)19-15-31(25-20(19)16(2)3)18-8-6-5-7-9-18/h5-9,12,14-16,21H,4,10-11,13H2,1-3H3 QEGBGOAMDCPBMZ-UHFFFAOYSA-N 175958 US9688684, Compound 155: 7-(1-Ethyl-1H-pyrazol-4-ylmethyl)-8-(3-isopropyl-1-phenyl-1H-pyrazol-4-yl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 24950 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175958 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175958&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169382 363892794 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473720 CC(C)c1nn(cc1C1N(Cc2cnn(C)c2C)CCn2nnnc12)-c1ccccc1 InChI=1S/C22H27N9/c1-15(2)20-19(14-31(25-20)18-8-6-5-7-9-18)21-22-24-26-27-30(22)11-10-29(21)13-17-12-23-28(4)16(17)3/h5-9,12,14-15,21H,10-11,13H2,1-4H3 GMCILCZRHDAQOS-UHFFFAOYSA-N 175959 US9688684, Compound 156: 7-(1,5-Dimethyl-1H-pyrazol-4-ylmethyl)-8-(3-isopropyl-1-phenyl-1H-pyrazol-4-yl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 24950 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175959 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175959&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169371 363892795 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473721 CC(C)c1nn(cc1C1N(Cc2cnn(C)c2C)CCn2nnnc12)-c1ccccc1 InChI=1S/C22H27N9/c1-15(2)20-19(14-31(25-20)18-8-6-5-7-9-18)21-22-24-26-27-30(22)11-10-29(21)13-17-12-23-28(4)16(17)3/h5-9,12,14-15,21H,10-11,13H2,1-4H3 GMCILCZRHDAQOS-UHFFFAOYSA-N 175959 US9688684, Compound 156: 7-(1,5-Dimethyl-1H-pyrazol-4-ylmethyl)-8-(3-isopropyl-1-phenyl-1H-pyrazol-4-yl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 24950 US Patent 10.7270/Q2DB7ZZK aid1794990 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175959 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175959&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169371 363892795 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473722 CC(C)c1nn(cc1C1N(Cc2c(C)nn(C)c2C)CCn2nnnc12)-c1ccccc1 InChI=1S/C23H29N9/c1-15(2)21-20(14-32(26-21)18-9-7-6-8-10-18)22-23-24-27-28-31(23)12-11-30(22)13-19-16(3)25-29(5)17(19)4/h6-10,14-15,22H,11-13H2,1-5H3 SKLKCYDAFGOFBZ-UHFFFAOYSA-N 175960 US9688684, Compound 157: 8-(3-Isopropyl-1-phenyl-1H-pyrazol-4-yl)-7-(1,3,5-trimethyl-1H-pyrazol-4-ylmethyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 24950 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175960 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175960&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 122639008 363892796 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473723 CC(C)c1nn(cc1C1N(Cc2ccccc2Cl)CCn2nnnc12)-c1ccccc1 InChI=1S/C23H24ClN7/c1-16(2)21-19(15-31(26-21)18-9-4-3-5-10-18)22-23-25-27-28-30(23)13-12-29(22)14-17-8-6-7-11-20(17)24/h3-11,15-16,22H,12-14H2,1-2H3 KSCQZPQXLFZSHS-UHFFFAOYSA-N 175961 US9688684, Compound 158: 7-(2-Chloro-benzyl)-8-(3-isopropyl-1-phenyl-1H-pyrazol-4-yl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 24950 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175961 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175961&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169516 363892797 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473724 Cn1cc(C2N(Cc3cccs3)CCn3nnnc23)c(n1)C1CC1 InChI=1S/C16H19N7S/c1-21-10-13(14(18-21)11-4-5-11)15-16-17-19-20-23(16)7-6-22(15)9-12-3-2-8-24-12/h2-3,8,10-11,15H,4-7,9H2,1H3 YWQYCJCYOKXJBR-UHFFFAOYSA-N 175962 US9688684, Compound 159: 8-(3-Cyclopropyl-1-methyl-1H-pyrazol-4-yl)-7-thiophen-2-ylmethyl-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 24950 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175962 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175962&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 118169436 363892798 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473725 CC(C)(C)c1nn(Cc2ccccc2)cc1C1N(Cc2cccs2)CCn2nnnc12 InChI=1S/C23H27N7S/c1-23(2,3)21-19(16-29(25-21)14-17-8-5-4-6-9-17)20-22-24-26-27-30(22)12-11-28(20)15-18-10-7-13-31-18/h4-10,13,16,20H,11-12,14-15H2,1-3H3 PMSFBOXPXRZOBD-UHFFFAOYSA-N 175963 US9688684, Compound 160: 8-(1-Benzyl-3-tert-butyl-1H-pyrazol-4-yl)-7-thiophen-2-ylmethyl-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 24950 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175963 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175963&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 122639001 363892799 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473726 CC(C)(C)c1nn(Cc2ccccc2)cc1C1N(Cc2cccs2)CCn2nnnc12 InChI=1S/C23H27N7S/c1-23(2,3)21-19(16-29(25-21)14-17-8-5-4-6-9-17)20-22-24-26-27-30(22)12-11-28(20)15-18-10-7-13-31-18/h4-10,13,16,20H,11-12,14-15H2,1-3H3 PMSFBOXPXRZOBD-UHFFFAOYSA-N 175963 US9688684, Compound 160: 8-(1-Benzyl-3-tert-butyl-1H-pyrazol-4-yl)-7-thiophen-2-ylmethyl-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 5445 US Patent 10.7270/Q2DB7ZZK aid1794990 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175963 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175963&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 122639001 363892799 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473727 CC(C)c1nn(cc1C1N(Cc2cnn(Cc3ccccc3)c2)CCn2nnnc12)-c1ccccc1 InChI=1S/C27H29N9/c1-20(2)25-24(19-36(30-25)23-11-7-4-8-12-23)26-27-29-31-32-35(27)14-13-33(26)16-22-15-28-34(18-22)17-21-9-5-3-6-10-21/h3-12,15,18-20,26H,13-14,16-17H2,1-2H3 DAFODRBASJYNTP-UHFFFAOYSA-N 175964 US9688684, Compound 161: 7-(1-Benzyl-1H-pyrazol-4-ylmethyl)-8-(3-isopropyl-1-phenyl-1H-pyrazol-4-yl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 5445 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175964 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175964&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 122639017 363892800 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473728 CC(C)c1nn(cc1C1N(Cc2cnn(Cc3ccccc3)c2)CCn2nnnc12)-c1ccccc1 InChI=1S/C27H29N9/c1-20(2)25-24(19-36(30-25)23-11-7-4-8-12-23)26-27-29-31-32-35(27)14-13-33(26)16-22-15-28-34(18-22)17-21-9-5-3-6-10-21/h3-12,15,18-20,26H,13-14,16-17H2,1-2H3 DAFODRBASJYNTP-UHFFFAOYSA-N 175964 US9688684, Compound 161: 7-(1-Benzyl-1H-pyrazol-4-ylmethyl)-8-(3-isopropyl-1-phenyl-1H-pyrazol-4-yl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 5445 US Patent 10.7270/Q2DB7ZZK aid1794990 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175964 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175964&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 122639017 363892800 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473729 CC(C)c1nn(Cc2ccccc2)cc1C1N(Cc2cccs2)CCn2nnnc12 InChI=1S/C22H25N7S/c1-16(2)20-19(15-28(24-20)13-17-7-4-3-5-8-17)21-22-23-25-26-29(22)11-10-27(21)14-18-9-6-12-30-18/h3-9,12,15-16,21H,10-11,13-14H2,1-2H3 FTJFDEPQTPZCBY-UHFFFAOYSA-N 175965 US9688684, Compound 162: 8-(1-Benzyl-3-isopropyl-1H-pyrazol-4-yl)-7-thiophen-2-ylmethyl-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 500 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175965 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175965&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 122639000 363892801 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473730 CC(C)c1nn(Cc2ccccc2)cc1C1N(Cc2cccs2)CCn2nnnc12 InChI=1S/C22H25N7S/c1-16(2)20-19(15-28(24-20)13-17-7-4-3-5-8-17)21-22-23-25-26-29(22)11-10-27(21)14-18-9-6-12-30-18/h3-9,12,15-16,21H,10-11,13-14H2,1-2H3 FTJFDEPQTPZCBY-UHFFFAOYSA-N 175965 US9688684, Compound 162: 8-(1-Benzyl-3-isopropyl-1H-pyrazol-4-yl)-7-thiophen-2-ylmethyl-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 5445 US Patent 10.7270/Q2DB7ZZK aid1794990 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175965 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175965&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 122639000 363892801 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473731 Fc1cccc(c1)C1N(Cc2cccc(Br)c2)CCn2nnnc12 InChI=1S/C17H15BrFN5/c18-14-5-1-3-12(9-14)11-23-7-8-24-17(20-21-22-24)16(23)13-4-2-6-15(19)10-13/h1-6,9-10,16H,7-8,11H2 WPIRLMSXYZYJMG-UHFFFAOYSA-N 175966 US9688684, Compound 163: 7-(3-Bromo-benzyl)-8-(3-fluoro-phenyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 500 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175966 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175966&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 122638993 363892802 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473732 Fc1cccc(c1)C1N(Cc2cccc(Br)c2)CCn2nnnc12 InChI=1S/C17H15BrFN5/c18-14-5-1-3-12(9-14)11-23-7-8-24-17(20-21-22-24)16(23)13-4-2-6-15(19)10-13/h1-6,9-10,16H,7-8,11H2 WPIRLMSXYZYJMG-UHFFFAOYSA-N 175966 US9688684, Compound 163: 7-(3-Bromo-benzyl)-8-(3-fluoro-phenyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine Nuclear receptor ROR-gamma [238-497] 24950 US Patent 10.7270/Q2DB7ZZK aid1794990 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175966 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175966&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 122638993 363892802 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473733 CN(C)c1ccc(cc1)C1N(Cc2ccccc2)CCn2nnnc12 InChI=1S/C19H22N6/c1-23(2)17-10-8-16(9-11-17)18-19-20-21-22-25(19)13-12-24(18)14-15-6-4-3-5-7-15/h3-11,18H,12-14H2,1-2H3 VOVNGVQLHWECJT-UHFFFAOYSA-N 175967 US9688684, Compound 164: [4-(7-Benzyl-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazin-8-yl)-phenyl]-dimethyl-amine Nuclear receptor ROR-gamma [238-497] 500 6.8 US Patent 10.7270/Q2DB7ZZK aid1794989 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175967 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175967&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 122639015 363892803 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 473734 CN(C)c1ccc(cc1)C1N(Cc2ccccc2)CCn2nnnc12 InChI=1S/C19H22N6/c1-23(2)17-10-8-16(9-11-17)18-19-20-21-22-25(19)13-12-24(18)14-15-6-4-3-5-7-15/h3-11,18H,12-14H2,1-2H3 VOVNGVQLHWECJT-UHFFFAOYSA-N 175967 US9688684, Compound 164: [4-(7-Benzyl-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazin-8-yl)-phenyl]-dimethyl-amine Nuclear receptor ROR-gamma [238-497] 24950 US Patent 10.7270/Q2DB7ZZK aid1794990 US9688684 Finsinger, D; Wucherer-Plietker, M; Blume, B Merck Patent GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175967 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=363&target=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175967&enzyme=Nuclear+receptor+ROR-gamma+%5B238-497%5D&column=ki&startPg=0&Increment=50&submit=Search 122639015 363892803 1 HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA 3B0W,3KYT,3L0J,3L0L,4NB6,4QM0,4S14,4WLB,4WPF,4WQP,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5IZ0,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J3N,6NAD,6NWS,6NWT,6NWU,6O98,6P9F,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6VSW,6W9H,6W9I,6XAE,6XFV,7E3M,7JH2,7JTM,7JYM,7KCO,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8