BindingDB Reactant_set_id Ligand SMILES Ligand InChI Ligand InChI Key BindingDB MonomerID BindingDB Ligand Name Target Name Target Source Organism According to Curator or DataSource Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) kon (M-1-s-1) koff (s-1) pH Temp (C) Curation/DataSource Article DOI BindingDB Entry DOI PMID PubChem AID Patent Number Authors Institution Link to Ligand in BindingDB Link to Target in BindingDB Link to Ligand-Target Pair in BindingDB Ligand HET ID in PDB PDB ID(s) for Ligand-Target Complex PubChem CID of Ligand PubChem SID of Ligand ChEBI ID of Ligand ChEMBL ID of Ligand DrugBank ID of Ligand IUPHAR_GRAC ID of Ligand KEGG ID of Ligand ZINC ID of Ligand Number of Protein Chains in Target (>1 implies a multichain complex) BindingDB Target Chain Sequence PDB ID(s) of Target Chain UniProt (SwissProt) Recommended Name of Target Chain UniProt (SwissProt) Entry Name of Target Chain UniProt (SwissProt) Primary ID of Target Chain UniProt (SwissProt) Secondary ID(s) of Target Chain UniProt (SwissProt) Alternative ID(s) of Target Chain UniProt (TrEMBL) Submitted Name of Target Chain UniProt (TrEMBL) Entry Name of Target Chain UniProt (TrEMBL) Primary ID of Target Chain UniProt (TrEMBL) Secondary ID(s) of Target Chain UniProt (TrEMBL) Alternative ID(s) of Target Chain 50481706 C1c2cc3Cn4cc[c+](NCCCCCCCCCCN[c+]5ccn(Cc6ccc(c1c6)-c2cc3)c1ccccc51)c1ccccc41 InChI=1S/C43H46N4/c1-2-4-6-12-24-45-41-22-26-47(43-16-10-8-14-39(41)43)31-33-18-20-37-35(28-33)29-34-27-32(17-19-36(34)37)30-46-25-21-40(44-23-11-5-3-1)38-13-7-9-15-42(38)46/h7-10,13-22,25-28,44-45H,1-6,11-12,23-24,29-31H2/q+2 ZZPDBNUHBXUUCM-UHFFFAOYSA-N 50289333 21,35-diazonia-2,13-diazaoctacyclo[33.6.2.214,21.123,27.129,33.015,20.026,30.036,41]heptatetraconta-1(41),14(45),15,17,19,21,23,25,27(47),29,31,33(46),35,37,39,42-hexadecaene::CHEMBL6207 Small conductance calcium-activated potassium channel protein 2 90 ChEMBL 10.1016/S0960-894X(96)00568-9 10.7270/Q22B8Z1R Rosa, JC; Beckwith-Hall, BM; Galanakis, D; Ganellin, CR; Dunn, PM; Jenkinson, DH TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50289333 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=342&target=Small+conductance+calcium-activated+potassium+channel+protein+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50289333&enzyme=Small+conductance+calcium-activated+potassium+channel+protein+2&column=ki&startPg=0&Increment=50&submit=Search 10605559 104130904 CHEMBL6207 ZINC25962733 1 MSSCRYNGGVMRPLSNLSSSRRNLHEMDSEAQPLQPPASVVGGGGGASSPSAAAAASSSAPEIVVSKPEHNNSNNLALYGTGGGGSTGGGGGGGGGGGGSGHGSSSGTKSSKKKNQNIGYKLGHRRALFEKRKRLSDYALIFGMFGIVVMVIETELSWGAYDKASLYSLALKCLISLSTIILLGLIIVYHAREIQLFMVDNGADDWRIAMTYERIFFICLEILVCAIHPIPGNYTFTWTARLAFSYAPSTTTADVDIILSIPMFLRLYLIARVMLLHSKLFTDASSRSIGALNKINFNTRFVMKTLMTICPGTVLLVFSISLWIIAAWTVRACERYHDQQDVTSNFLGAMWLISITFLSIGYGDMVPNTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRVKNAAANVLRETWLIYKNTKLVKKIDHAKVRKHQRKFLQAIHQLRSVKMEQRKLNDQANTLVDLAKTQNIMYDMISDLNERSEDFEKRIVTLETKLETLIGSIHALPGLISQTIRQQQRDFIETQMENYDKHVTYNAERSRSSSRRRRSSSTAPPTSSESS 1QX7 Small conductance calcium-activated potassium channel protein 2 KCNN2_RAT P70604 50481707 C1CCCCCN[c+]2ccn(Cc3ccc(CCc4ccc(Cn5cc[c+](NCCCC1)c1ccccc51)cc4)cc3)c1ccccc21 InChI=1S/C44H50N4/c1-2-4-6-12-30-46-42-28-32-48(44-16-10-8-14-40(42)44)34-38-25-21-36(22-26-38)18-17-35-19-23-37(24-20-35)33-47-31-27-41(45-29-11-5-3-1)39-13-7-9-15-43(39)47/h7-10,13-16,19-28,31-32,45-46H,1-6,11-12,17-18,29-30,33-34H2/q+2 YBUJEFDKDCEBNG-UHFFFAOYSA-N 50084851 Bis-quinolinium cyclophane analogue::CHEMBL266885::Cyclo N-decane(1-{4-[4-(4-amino-1-quinoliniumylmethyl)phenethyl]benzyl}-4-quinoliniumamine) Small conductance calcium-activated potassium channel protein 2 180 ChEMBL 10.1016/S0960-894X(96)00568-9 10.7270/Q22B8Z1R Rosa, JC; Beckwith-Hall, BM; Galanakis, D; Ganellin, CR; Dunn, PM; Jenkinson, DH TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50084851 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=342&target=Small+conductance+calcium-activated+potassium+channel+protein+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50084851&enzyme=Small+conductance+calcium-activated+potassium+channel+protein+2&column=ki&startPg=0&Increment=50&submit=Search 11803708 103984379 CHEMBL266885 ZINC25962752 1 MSSCRYNGGVMRPLSNLSSSRRNLHEMDSEAQPLQPPASVVGGGGGASSPSAAAAASSSAPEIVVSKPEHNNSNNLALYGTGGGGSTGGGGGGGGGGGGSGHGSSSGTKSSKKKNQNIGYKLGHRRALFEKRKRLSDYALIFGMFGIVVMVIETELSWGAYDKASLYSLALKCLISLSTIILLGLIIVYHAREIQLFMVDNGADDWRIAMTYERIFFICLEILVCAIHPIPGNYTFTWTARLAFSYAPSTTTADVDIILSIPMFLRLYLIARVMLLHSKLFTDASSRSIGALNKINFNTRFVMKTLMTICPGTVLLVFSISLWIIAAWTVRACERYHDQQDVTSNFLGAMWLISITFLSIGYGDMVPNTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRVKNAAANVLRETWLIYKNTKLVKKIDHAKVRKHQRKFLQAIHQLRSVKMEQRKLNDQANTLVDLAKTQNIMYDMISDLNERSEDFEKRIVTLETKLETLIGSIHALPGLISQTIRQQQRDFIETQMENYDKHVTYNAERSRSSSRRRRSSSTAPPTSSESS 1QX7 Small conductance calcium-activated potassium channel protein 2 KCNN2_RAT P70604 50481708 C(CCCCC\[NH+]=c1/ccn(Cc2ccccc2)c2ccccc12)CCCC\[NH+]=c1/ccn(Cc2ccccc2)c2ccccc12 InChI=1S/C42H46N4/c1(3-5-17-29-43-39-27-31-45(33-35-19-9-7-10-20-35)41-25-15-13-23-37(39)41)2-4-6-18-30-44-40-28-32-46(34-36-21-11-8-12-22-36)42-26-16-14-24-38(40)42/h7-16,19-28,31-32H,1-6,17-18,29-30,33-34H2/p+2/b43-39+,44-40+ JFTHHZLVWUKENE-UUHCYPSGSA-P 50048412 4N-[10-(1-benzyl-4-quinoliniumylamino)decyl]-1-benzyl-4-quinoliniumamine::CHEMBL6212 Small conductance calcium-activated potassium channel protein 2 700 ChEMBL 10.1016/S0960-894X(96)00568-9 10.7270/Q22B8Z1R Rosa, JC; Beckwith-Hall, BM; Galanakis, D; Ganellin, CR; Dunn, PM; Jenkinson, DH TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50048412 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=342&target=Small+conductance+calcium-activated+potassium+channel+protein+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50048412&enzyme=Small+conductance+calcium-activated+potassium+channel+protein+2&column=ki&startPg=0&Increment=50&submit=Search 10605201 103978877 CHEMBL6212 ZINC25962747 1 MSSCRYNGGVMRPLSNLSSSRRNLHEMDSEAQPLQPPASVVGGGGGASSPSAAAAASSSAPEIVVSKPEHNNSNNLALYGTGGGGSTGGGGGGGGGGGGSGHGSSSGTKSSKKKNQNIGYKLGHRRALFEKRKRLSDYALIFGMFGIVVMVIETELSWGAYDKASLYSLALKCLISLSTIILLGLIIVYHAREIQLFMVDNGADDWRIAMTYERIFFICLEILVCAIHPIPGNYTFTWTARLAFSYAPSTTTADVDIILSIPMFLRLYLIARVMLLHSKLFTDASSRSIGALNKINFNTRFVMKTLMTICPGTVLLVFSISLWIIAAWTVRACERYHDQQDVTSNFLGAMWLISITFLSIGYGDMVPNTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRVKNAAANVLRETWLIYKNTKLVKKIDHAKVRKHQRKFLQAIHQLRSVKMEQRKLNDQANTLVDLAKTQNIMYDMISDLNERSEDFEKRIVTLETKLETLIGSIHALPGLISQTIRQQQRDFIETQMENYDKHVTYNAERSRSSSRRRRSSSTAPPTSSESS 1QX7 Small conductance calcium-activated potassium channel protein 2 KCNN2_RAT P70604 50481709 C1CCCCCN[c+]2ccn(Cc3ccc(Cc4ccc(Cn5cc[c+](NCCCC1)c1ccccc51)cc4)cc3)c1ccccc21 InChI=1S/C43H48N4/c1-2-4-6-12-28-45-41-26-30-47(43-16-10-8-14-39(41)43)33-37-23-19-35(20-24-37)31-34-17-21-36(22-18-34)32-46-29-25-40(44-27-11-5-3-1)38-13-7-9-15-42(38)46/h7-10,13-26,29-30,44-45H,1-6,11-12,27-28,31-33H2/q+2 NWUHMRZECZQMJQ-UHFFFAOYSA-N 50084848 BIs-cyclo(4N-pentyl-1-(4-methylbenzyl)-4-quinoliniumamine)::Bis-quinolinium cyclophane analogue::CHEMBL446445::UCL-1530 Small conductance calcium-activated potassium channel protein 2 80 ChEMBL 10.1016/S0960-894X(96)00568-9 10.7270/Q22B8Z1R Rosa, JC; Beckwith-Hall, BM; Galanakis, D; Ganellin, CR; Dunn, PM; Jenkinson, DH TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50084848 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=342&target=Small+conductance+calcium-activated+potassium+channel+protein+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50084848&enzyme=Small+conductance+calcium-activated+potassium+channel+protein+2&column=ki&startPg=0&Increment=50&submit=Search 10557503 103984376 CHEMBL446445 ZINC25964084 1 MSSCRYNGGVMRPLSNLSSSRRNLHEMDSEAQPLQPPASVVGGGGGASSPSAAAAASSSAPEIVVSKPEHNNSNNLALYGTGGGGSTGGGGGGGGGGGGSGHGSSSGTKSSKKKNQNIGYKLGHRRALFEKRKRLSDYALIFGMFGIVVMVIETELSWGAYDKASLYSLALKCLISLSTIILLGLIIVYHAREIQLFMVDNGADDWRIAMTYERIFFICLEILVCAIHPIPGNYTFTWTARLAFSYAPSTTTADVDIILSIPMFLRLYLIARVMLLHSKLFTDASSRSIGALNKINFNTRFVMKTLMTICPGTVLLVFSISLWIIAAWTVRACERYHDQQDVTSNFLGAMWLISITFLSIGYGDMVPNTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRVKNAAANVLRETWLIYKNTKLVKKIDHAKVRKHQRKFLQAIHQLRSVKMEQRKLNDQANTLVDLAKTQNIMYDMISDLNERSEDFEKRIVTLETKLETLIGSIHALPGLISQTIRQQQRDFIETQMENYDKHVTYNAERSRSSSRRRRSSSTAPPTSSESS 1QX7 Small conductance calcium-activated potassium channel protein 2 KCNN2_RAT P70604 50481710 [NH2+]=c1ccn(Cc2cccc(c2)-c2cccc(Cn3ccc(=[NH2+])c4ccccc34)c2)c2ccccc12 InChI=1S/C32H26N4/c33-29-15-17-35(31-13-3-1-11-27(29)31)21-23-7-5-9-25(19-23)26-10-6-8-24(20-26)22-36-18-16-30(34)28-12-2-4-14-32(28)36/h1-20,33-34H,21-22H2/p+2 CKEYKKQODPYQPS-UHFFFAOYSA-P 50054098 1,1'-[biphenyl-3,3'-diylbis(methylene)]-bis(4-aminoquinolinium)::1-{3-[3-(4-amino-1-quinoliniumylmethyl)phenyl]benzyl}-4-quinoliniumamine::CHEMBL370057::CHEMBL6354 Small conductance calcium-activated potassium channel protein 2 290 ChEMBL 10.1016/S0960-894X(96)00568-9 10.7270/Q22B8Z1R Rosa, JC; Beckwith-Hall, BM; Galanakis, D; Ganellin, CR; Dunn, PM; Jenkinson, DH TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054098 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=342&target=Small+conductance+calcium-activated+potassium+channel+protein+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054098&enzyme=Small+conductance+calcium-activated+potassium+channel+protein+2&column=ki&startPg=0&Increment=50&submit=Search 10770265 103950754 CHEMBL370057CHEMBL6354 ZINC13604525 1 MSSCRYNGGVMRPLSNLSSSRRNLHEMDSEAQPLQPPASVVGGGGGASSPSAAAAASSSAPEIVVSKPEHNNSNNLALYGTGGGGSTGGGGGGGGGGGGSGHGSSSGTKSSKKKNQNIGYKLGHRRALFEKRKRLSDYALIFGMFGIVVMVIETELSWGAYDKASLYSLALKCLISLSTIILLGLIIVYHAREIQLFMVDNGADDWRIAMTYERIFFICLEILVCAIHPIPGNYTFTWTARLAFSYAPSTTTADVDIILSIPMFLRLYLIARVMLLHSKLFTDASSRSIGALNKINFNTRFVMKTLMTICPGTVLLVFSISLWIIAAWTVRACERYHDQQDVTSNFLGAMWLISITFLSIGYGDMVPNTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRVKNAAANVLRETWLIYKNTKLVKKIDHAKVRKHQRKFLQAIHQLRSVKMEQRKLNDQANTLVDLAKTQNIMYDMISDLNERSEDFEKRIVTLETKLETLIGSIHALPGLISQTIRQQQRDFIETQMENYDKHVTYNAERSRSSSRRRRSSSTAPPTSSESS 1QX7 Small conductance calcium-activated potassium channel protein 2 KCNN2_RAT P70604 50481711 [NH2+]=c1ccn(Cc2ccc(\C=C/c3ccc(Cn4ccc(=[NH2+])c5ccccc45)cc3)cc2)c2ccccc12 InChI=1S/C34H28N4/c35-31-19-21-37(33-7-3-1-5-29(31)33)23-27-15-11-25(12-16-27)9-10-26-13-17-28(18-14-26)24-38-22-20-32(36)30-6-2-4-8-34(30)38/h1-22,35-36H,23-24H2/p+2/b10-9-,35-31?,36-32? VERLYKWASWBHLC-PBPHPUJQSA-P 50054105 (Z)-1.1'-[stilbene-4,4'-diylbis(methylene)]bis(4-aminoquinolinium)::1-{4-[2-[4-(4-amino-1-quinoliniumylmethyl)phenyl]-(Z)-1-ethenyl]benzyl}-4-quinoliniumamine::CHEMBL6361 Small conductance calcium-activated potassium channel protein 2 190 ChEMBL 10.1016/S0960-894X(96)00568-9 10.7270/Q22B8Z1R Rosa, JC; Beckwith-Hall, BM; Galanakis, D; Ganellin, CR; Dunn, PM; Jenkinson, DH TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054105 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=342&target=Small+conductance+calcium-activated+potassium+channel+protein+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054105&enzyme=Small+conductance+calcium-activated+potassium+channel+protein+2&column=ki&startPg=0&Increment=50&submit=Search 10028627 103950757 CHEMBL6361 ZINC13604537 1 MSSCRYNGGVMRPLSNLSSSRRNLHEMDSEAQPLQPPASVVGGGGGASSPSAAAAASSSAPEIVVSKPEHNNSNNLALYGTGGGGSTGGGGGGGGGGGGSGHGSSSGTKSSKKKNQNIGYKLGHRRALFEKRKRLSDYALIFGMFGIVVMVIETELSWGAYDKASLYSLALKCLISLSTIILLGLIIVYHAREIQLFMVDNGADDWRIAMTYERIFFICLEILVCAIHPIPGNYTFTWTARLAFSYAPSTTTADVDIILSIPMFLRLYLIARVMLLHSKLFTDASSRSIGALNKINFNTRFVMKTLMTICPGTVLLVFSISLWIIAAWTVRACERYHDQQDVTSNFLGAMWLISITFLSIGYGDMVPNTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRVKNAAANVLRETWLIYKNTKLVKKIDHAKVRKHQRKFLQAIHQLRSVKMEQRKLNDQANTLVDLAKTQNIMYDMISDLNERSEDFEKRIVTLETKLETLIGSIHALPGLISQTIRQQQRDFIETQMENYDKHVTYNAERSRSSSRRRRSSSTAPPTSSESS 1QX7 Small conductance calcium-activated potassium channel protein 2 KCNN2_RAT P70604 50481712 [NH2+]=c1ccn(Cc2ccc(cc2)-c2ccc(Cn3ccc(=[NH2+])c4ccccc34)cc2)c2ccccc12 InChI=1S/C32H26N4/c33-29-17-19-35(31-7-3-1-5-27(29)31)21-23-9-13-25(14-10-23)26-15-11-24(12-16-26)22-36-20-18-30(34)28-6-2-4-8-32(28)36/h1-20,33-34H,21-22H2/p+2 BJOSVLNMVXPCHZ-UHFFFAOYSA-P 50054103 1,1'-[biphenyl-4,4'-diylbis(methylene)]-bis(4-aminoquinolinium)::1-{4-[4-(4-amino-1-quinoliniumylmethyl)phenyl]benzyl}-4-quinoliniumamine::CHEMBL269729::CHEMBL370040 Small conductance calcium-activated potassium channel protein 2 380 ChEMBL 10.1016/S0960-894X(96)00568-9 10.7270/Q22B8Z1R Rosa, JC; Beckwith-Hall, BM; Galanakis, D; Ganellin, CR; Dunn, PM; Jenkinson, DH TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054103 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=342&target=Small+conductance+calcium-activated+potassium+channel+protein+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054103&enzyme=Small+conductance+calcium-activated+potassium+channel+protein+2&column=ki&startPg=0&Increment=50&submit=Search 10580530 103950756 CHEMBL370040CHEMBL269729 ZINC13604527 1 MSSCRYNGGVMRPLSNLSSSRRNLHEMDSEAQPLQPPASVVGGGGGASSPSAAAAASSSAPEIVVSKPEHNNSNNLALYGTGGGGSTGGGGGGGGGGGGSGHGSSSGTKSSKKKNQNIGYKLGHRRALFEKRKRLSDYALIFGMFGIVVMVIETELSWGAYDKASLYSLALKCLISLSTIILLGLIIVYHAREIQLFMVDNGADDWRIAMTYERIFFICLEILVCAIHPIPGNYTFTWTARLAFSYAPSTTTADVDIILSIPMFLRLYLIARVMLLHSKLFTDASSRSIGALNKINFNTRFVMKTLMTICPGTVLLVFSISLWIIAAWTVRACERYHDQQDVTSNFLGAMWLISITFLSIGYGDMVPNTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRVKNAAANVLRETWLIYKNTKLVKKIDHAKVRKHQRKFLQAIHQLRSVKMEQRKLNDQANTLVDLAKTQNIMYDMISDLNERSEDFEKRIVTLETKLETLIGSIHALPGLISQTIRQQQRDFIETQMENYDKHVTYNAERSRSSSRRRRSSSTAPPTSSESS 1QX7 Small conductance calcium-activated potassium channel protein 2 KCNN2_RAT P70604 50481713 C1CCCCCN[c+]2ccn(Cc3ccc(cc3)\C=C/c3ccc(Cn4cc[c+](NCCCC1)c1ccccc41)cc3)c1ccccc21 InChI=1S/C44H48N4/c1-2-4-6-12-30-46-42-28-32-48(44-16-10-8-14-40(42)44)34-38-25-21-36(22-26-38)18-17-35-19-23-37(24-20-35)33-47-31-27-41(45-29-11-5-3-1)39-13-7-9-15-43(39)47/h7-10,13-28,31-32,45-46H,1-6,11-12,29-30,33-34H2/q+2/b18-17- XDWIBNDNEBICCV-ZCXUNETKSA-N 50084849 Bis-quinolinium cyclophane analogue::CHEMBL258254::Cyclo(N-decane1-{4-[2-[4-(4-amino-1-quinoliniumylmethyl)phenyl]-(Z)-1-ethenyl]benzyl}-4-quinoliniumamine) Small conductance calcium-activated potassium channel protein 2 150 ChEMBL 10.1016/S0960-894X(96)00568-9 10.7270/Q22B8Z1R Rosa, JC; Beckwith-Hall, BM; Galanakis, D; Ganellin, CR; Dunn, PM; Jenkinson, DH TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50084849 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=342&target=Small+conductance+calcium-activated+potassium+channel+protein+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50084849&enzyme=Small+conductance+calcium-activated+potassium+channel+protein+2&column=ki&startPg=0&Increment=50&submit=Search 10819402 103984377 CHEMBL258254 1 MSSCRYNGGVMRPLSNLSSSRRNLHEMDSEAQPLQPPASVVGGGGGASSPSAAAAASSSAPEIVVSKPEHNNSNNLALYGTGGGGSTGGGGGGGGGGGGSGHGSSSGTKSSKKKNQNIGYKLGHRRALFEKRKRLSDYALIFGMFGIVVMVIETELSWGAYDKASLYSLALKCLISLSTIILLGLIIVYHAREIQLFMVDNGADDWRIAMTYERIFFICLEILVCAIHPIPGNYTFTWTARLAFSYAPSTTTADVDIILSIPMFLRLYLIARVMLLHSKLFTDASSRSIGALNKINFNTRFVMKTLMTICPGTVLLVFSISLWIIAAWTVRACERYHDQQDVTSNFLGAMWLISITFLSIGYGDMVPNTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRVKNAAANVLRETWLIYKNTKLVKKIDHAKVRKHQRKFLQAIHQLRSVKMEQRKLNDQANTLVDLAKTQNIMYDMISDLNERSEDFEKRIVTLETKLETLIGSIHALPGLISQTIRQQQRDFIETQMENYDKHVTYNAERSRSSSRRRRSSSTAPPTSSESS 1QX7 Small conductance calcium-activated potassium channel protein 2 KCNN2_RAT P70604 50481714 C1CCCCCN[c+]2ccn(Cc3cccc(c3)-c3cccc(Cn4cc[c+](NCCCC1)c1ccccc41)c3)c1ccccc21 InChI=1S/C42H46N4/c1-2-4-6-12-26-44-40-24-28-46(42-22-10-8-20-38(40)42)32-34-16-14-18-36(30-34)35-17-13-15-33(29-35)31-45-27-23-39(43-25-11-5-3-1)37-19-7-9-21-41(37)45/h7-10,13-24,27-30,43-44H,1-6,11-12,25-26,31-32H2/q+2 HSKLDYFGAMUEER-UHFFFAOYSA-N 50084852 1,14-diazonia-22,33-diazaheptacyclo[32.6.2.214,21.13,7.18,12.015,20.035,40]hexatetraconta-1(40),3,5,7(46),8(45),9,11,14,15,17,19,21(43),34,36,38,41-hexadecaene::4N-[10-(1-methyl-4-quinoliniumylamino)decyl]-1-[3-(3-methylphenyl)benzyl]-4-quinoliniumamine::CHEMBL268556 Small conductance calcium-activated potassium channel protein 2 110 ChEMBL 10.1016/S0960-894X(96)00568-9 10.7270/Q22B8Z1R Rosa, JC; Beckwith-Hall, BM; Galanakis, D; Ganellin, CR; Dunn, PM; Jenkinson, DH TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50084852 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=342&target=Small+conductance+calcium-activated+potassium+channel+protein+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50084852&enzyme=Small+conductance+calcium-activated+potassium+channel+protein+2&column=ki&startPg=0&Increment=50&submit=Search 10676941 103984380 CHEMBL268556 ZINC25964093 1 MSSCRYNGGVMRPLSNLSSSRRNLHEMDSEAQPLQPPASVVGGGGGASSPSAAAAASSSAPEIVVSKPEHNNSNNLALYGTGGGGSTGGGGGGGGGGGGSGHGSSSGTKSSKKKNQNIGYKLGHRRALFEKRKRLSDYALIFGMFGIVVMVIETELSWGAYDKASLYSLALKCLISLSTIILLGLIIVYHAREIQLFMVDNGADDWRIAMTYERIFFICLEILVCAIHPIPGNYTFTWTARLAFSYAPSTTTADVDIILSIPMFLRLYLIARVMLLHSKLFTDASSRSIGALNKINFNTRFVMKTLMTICPGTVLLVFSISLWIIAAWTVRACERYHDQQDVTSNFLGAMWLISITFLSIGYGDMVPNTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRVKNAAANVLRETWLIYKNTKLVKKIDHAKVRKHQRKFLQAIHQLRSVKMEQRKLNDQANTLVDLAKTQNIMYDMISDLNERSEDFEKRIVTLETKLETLIGSIHALPGLISQTIRQQQRDFIETQMENYDKHVTYNAERSRSSSRRRRSSSTAPPTSSESS 1QX7 Small conductance calcium-activated potassium channel protein 2 KCNN2_RAT P70604 50481715 [NH2+]=c1ccn(Cc2ccc(Cc3ccc(Cn4ccc(=[NH2+])c5ccccc45)cc3)cc2)c2ccccc12 InChI=1S/C33H28N4/c34-30-17-19-36(32-7-3-1-5-28(30)32)22-26-13-9-24(10-14-26)21-25-11-15-27(16-12-25)23-37-20-18-31(35)29-6-2-4-8-33(29)37/h1-20,34-35H,21-23H2/p+2 YEQQDIAUPMSMFF-UHFFFAOYSA-P 50054096 1-{4-[4-(4-amino-1-quinoliniumylmethyl)benzyl]benzyl}-4-quinoliniumamine::1.1'-[methylenebis(benzene-1,4-diylmethylene)]bis(4-aminoquinolinium)::CHEMBL6315 Small conductance calcium-activated potassium channel protein 2 450 ChEMBL 10.1016/S0960-894X(96)00568-9 10.7270/Q22B8Z1R Rosa, JC; Beckwith-Hall, BM; Galanakis, D; Ganellin, CR; Dunn, PM; Jenkinson, DH TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054096 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=342&target=Small+conductance+calcium-activated+potassium+channel+protein+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054096&enzyme=Small+conductance+calcium-activated+potassium+channel+protein+2&column=ki&startPg=0&Increment=50&submit=Search 10532193 103950753 CHEMBL6315 ZINC13604533 1 MSSCRYNGGVMRPLSNLSSSRRNLHEMDSEAQPLQPPASVVGGGGGASSPSAAAAASSSAPEIVVSKPEHNNSNNLALYGTGGGGSTGGGGGGGGGGGGSGHGSSSGTKSSKKKNQNIGYKLGHRRALFEKRKRLSDYALIFGMFGIVVMVIETELSWGAYDKASLYSLALKCLISLSTIILLGLIIVYHAREIQLFMVDNGADDWRIAMTYERIFFICLEILVCAIHPIPGNYTFTWTARLAFSYAPSTTTADVDIILSIPMFLRLYLIARVMLLHSKLFTDASSRSIGALNKINFNTRFVMKTLMTICPGTVLLVFSISLWIIAAWTVRACERYHDQQDVTSNFLGAMWLISITFLSIGYGDMVPNTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRVKNAAANVLRETWLIYKNTKLVKKIDHAKVRKHQRKFLQAIHQLRSVKMEQRKLNDQANTLVDLAKTQNIMYDMISDLNERSEDFEKRIVTLETKLETLIGSIHALPGLISQTIRQQQRDFIETQMENYDKHVTYNAERSRSSSRRRRSSSTAPPTSSESS 1QX7 Small conductance calcium-activated potassium channel protein 2 KCNN2_RAT P70604 50481716 [NH2+]=c1ccn(Cc2ccc(CCc3ccc(Cn4ccc(=[NH2+])c5ccccc45)cc3)cc2)c2ccccc12 InChI=1S/C34H30N4/c35-31-19-21-37(33-7-3-1-5-29(31)33)23-27-15-11-25(12-16-27)9-10-26-13-17-28(18-14-26)24-38-22-20-32(36)30-6-2-4-8-34(30)38/h1-8,11-22,35-36H,9-10,23-24H2/p+2 SSYLZSFCNUGCEN-UHFFFAOYSA-P 50054095 1-{4-[4-(4-amino-1-quinoliniumylmethyl)phenethyl]benzyl}-4-quinoliniumamine::1.1'-[ethylenebis(benzene-1,4-diylmethylene)]bis(4-aminoquinolinium)::CHEMBL362961::CHEMBL429017 Small conductance calcium-activated potassium channel protein 2 410 ChEMBL 10.1016/S0960-894X(96)00568-9 10.7270/Q22B8Z1R Rosa, JC; Beckwith-Hall, BM; Galanakis, D; Ganellin, CR; Dunn, PM; Jenkinson, DH TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054095 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=342&target=Small+conductance+calcium-activated+potassium+channel+protein+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054095&enzyme=Small+conductance+calcium-activated+potassium+channel+protein+2&column=ki&startPg=0&Increment=50&submit=Search 10628096 103950752 CHEMBL362961CHEMBL429017 ZINC13604535 1 MSSCRYNGGVMRPLSNLSSSRRNLHEMDSEAQPLQPPASVVGGGGGASSPSAAAAASSSAPEIVVSKPEHNNSNNLALYGTGGGGSTGGGGGGGGGGGGSGHGSSSGTKSSKKKNQNIGYKLGHRRALFEKRKRLSDYALIFGMFGIVVMVIETELSWGAYDKASLYSLALKCLISLSTIILLGLIIVYHAREIQLFMVDNGADDWRIAMTYERIFFICLEILVCAIHPIPGNYTFTWTARLAFSYAPSTTTADVDIILSIPMFLRLYLIARVMLLHSKLFTDASSRSIGALNKINFNTRFVMKTLMTICPGTVLLVFSISLWIIAAWTVRACERYHDQQDVTSNFLGAMWLISITFLSIGYGDMVPNTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRVKNAAANVLRETWLIYKNTKLVKKIDHAKVRKHQRKFLQAIHQLRSVKMEQRKLNDQANTLVDLAKTQNIMYDMISDLNERSEDFEKRIVTLETKLETLIGSIHALPGLISQTIRQQQRDFIETQMENYDKHVTYNAERSRSSSRRRRSSSTAPPTSSESS 1QX7 Small conductance calcium-activated potassium channel protein 2 KCNN2_RAT P70604 50481717 C1CCCCCN[c+]2ccn(Cc3ccc(cc3)-c3ccc(Cn4cc[c+](NCCCC1)c1ccccc41)cc3)c1ccccc21 InChI=1S/C42H46N4/c1-2-4-6-12-28-44-40-26-30-46(42-16-10-8-14-38(40)42)32-34-19-23-36(24-20-34)35-21-17-33(18-22-35)31-45-29-25-39(43-27-11-5-3-1)37-13-7-9-15-41(37)45/h7-10,13-26,29-30,43-44H,1-6,11-12,27-28,31-32H2/q+2 PTPPSEJOOLOWCK-UHFFFAOYSA-N 50084839 Bis-quinolinium cyclophane analogue::CHEMBL6266::cyclo N-decane(1-{4-[4-(4-amino-1-quinoliniumylmethyl)phenyl]benzyl}-4-quinoliniumamine) Small conductance calcium-activated potassium channel protein 2 170 ChEMBL 10.1016/S0960-894X(96)00568-9 10.7270/Q22B8Z1R Rosa, JC; Beckwith-Hall, BM; Galanakis, D; Ganellin, CR; Dunn, PM; Jenkinson, DH TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50084839 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=342&target=Small+conductance+calcium-activated+potassium+channel+protein+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50084839&enzyme=Small+conductance+calcium-activated+potassium+channel+protein+2&column=ki&startPg=0&Increment=50&submit=Search 10700681 103984367 CHEMBL6266 ZINC25963197 1 MSSCRYNGGVMRPLSNLSSSRRNLHEMDSEAQPLQPPASVVGGGGGASSPSAAAAASSSAPEIVVSKPEHNNSNNLALYGTGGGGSTGGGGGGGGGGGGSGHGSSSGTKSSKKKNQNIGYKLGHRRALFEKRKRLSDYALIFGMFGIVVMVIETELSWGAYDKASLYSLALKCLISLSTIILLGLIIVYHAREIQLFMVDNGADDWRIAMTYERIFFICLEILVCAIHPIPGNYTFTWTARLAFSYAPSTTTADVDIILSIPMFLRLYLIARVMLLHSKLFTDASSRSIGALNKINFNTRFVMKTLMTICPGTVLLVFSISLWIIAAWTVRACERYHDQQDVTSNFLGAMWLISITFLSIGYGDMVPNTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRVKNAAANVLRETWLIYKNTKLVKKIDHAKVRKHQRKFLQAIHQLRSVKMEQRKLNDQANTLVDLAKTQNIMYDMISDLNERSEDFEKRIVTLETKLETLIGSIHALPGLISQTIRQQQRDFIETQMENYDKHVTYNAERSRSSSRRRRSSSTAPPTSSESS 1QX7 Small conductance calcium-activated potassium channel protein 2 KCNN2_RAT P70604 50481718 [NH2+]=c1ccn(Cc2ccc-3c(Cc4cc(Cn5ccc(=[NH2+])c6ccccc56)ccc-34)c2)c2ccccc12 InChI=1S/C33H26N4/c34-30-13-15-36(32-7-3-1-5-28(30)32)20-22-9-11-26-24(17-22)19-25-18-23(10-12-27(25)26)21-37-16-14-31(35)29-6-2-4-8-33(29)37/h1-18,34-35H,19-21H2/p+2 USOMLPZSQWAHIS-UHFFFAOYSA-P 50084846 1-[7-(4-amino-1-quinoliniumylmethyl)-9H-2-fluorenylmethyl]-4-quinoliniumamine::CHEMBL6356 Small conductance calcium-activated potassium channel protein 2 310 ChEMBL 10.1016/S0960-894X(96)00568-9 10.7270/Q22B8Z1R Rosa, JC; Beckwith-Hall, BM; Galanakis, D; Ganellin, CR; Dunn, PM; Jenkinson, DH TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50084846 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=342&target=Small+conductance+calcium-activated+potassium+channel+protein+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50084846&enzyme=Small+conductance+calcium-activated+potassium+channel+protein+2&column=ki&startPg=0&Increment=50&submit=Search 10723455 103984374 CHEMBL6356 ZINC13604531 1 MSSCRYNGGVMRPLSNLSSSRRNLHEMDSEAQPLQPPASVVGGGGGASSPSAAAAASSSAPEIVVSKPEHNNSNNLALYGTGGGGSTGGGGGGGGGGGGSGHGSSSGTKSSKKKNQNIGYKLGHRRALFEKRKRLSDYALIFGMFGIVVMVIETELSWGAYDKASLYSLALKCLISLSTIILLGLIIVYHAREIQLFMVDNGADDWRIAMTYERIFFICLEILVCAIHPIPGNYTFTWTARLAFSYAPSTTTADVDIILSIPMFLRLYLIARVMLLHSKLFTDASSRSIGALNKINFNTRFVMKTLMTICPGTVLLVFSISLWIIAAWTVRACERYHDQQDVTSNFLGAMWLISITFLSIGYGDMVPNTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRVKNAAANVLRETWLIYKNTKLVKKIDHAKVRKHQRKFLQAIHQLRSVKMEQRKLNDQANTLVDLAKTQNIMYDMISDLNERSEDFEKRIVTLETKLETLIGSIHALPGLISQTIRQQQRDFIETQMENYDKHVTYNAERSRSSSRRRRSSSTAPPTSSESS 1QX7 Small conductance calcium-activated potassium channel protein 2 KCNN2_RAT P70604 50699385 CC(C)c1cccc2cc[n+](C)c(Cc3cccc(Cc4[n+](C)ccc5cccc(C(C)C)c45)c3)c12 InChI=1S/C34H38N2/c1-23(2)29-14-8-12-27-16-18-35(5)31(33(27)29)21-25-10-7-11-26(20-25)22-32-34-28(17-19-36(32)6)13-9-15-30(34)24(3)4/h7-20,23-24H,21-22H2,1-6H3/q+2 XMROENZSOFWKAA-UHFFFAOYSA-N 50356161 CHEMBL1909931 Small conductance calcium-activated potassium channel protein 2 1600 ChEMBL 10.1016/j.bmcl.2011.09.043 10.7270/Q2R211S7 21978678 Badarau, E; Dilly, S; Dufour, F; Poncin, S; Seutin, V; Liegeois, JF University of Li£ge http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50356161 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=342&target=Small+conductance+calcium-activated+potassium+channel+protein+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50356161&enzyme=Small+conductance+calcium-activated+potassium+channel+protein+2&column=ki&startPg=0&Increment=50&submit=Search 57401349 136960185 CHEMBL1909931 ZINC73129877 1 MSSCRYNGGVMRPLSNLSSSRRNLHEMDSEAQPLQPPASVVGGGGGASSPSAAAAASSSAPEIVVSKPEHNNSNNLALYGTGGGGSTGGGGGGGGGGGGSGHGSSSGTKSSKKKNQNIGYKLGHRRALFEKRKRLSDYALIFGMFGIVVMVIETELSWGAYDKASLYSLALKCLISLSTIILLGLIIVYHAREIQLFMVDNGADDWRIAMTYERIFFICLEILVCAIHPIPGNYTFTWTARLAFSYAPSTTTADVDIILSIPMFLRLYLIARVMLLHSKLFTDASSRSIGALNKINFNTRFVMKTLMTICPGTVLLVFSISLWIIAAWTVRACERYHDQQDVTSNFLGAMWLISITFLSIGYGDMVPNTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRVKNAAANVLRETWLIYKNTKLVKKIDHAKVRKHQRKFLQAIHQLRSVKMEQRKLNDQANTLVDLAKTQNIMYDMISDLNERSEDFEKRIVTLETKLETLIGSIHALPGLISQTIRQQQRDFIETQMENYDKHVTYNAERSRSSSRRRRSSSTAPPTSSESS 1QX7 Small conductance calcium-activated potassium channel protein 2 KCNN2_RAT P70604 470822 Nc1nc2ccc(SC(F)(F)F)cc2s1 InChI=1S/C8H5F3N2S2/c9-8(10,11)15-4-1-2-5-6(3-4)14-7(12)13-5/h1-3H,(H2,12,13) PBRVVEXJMLEKMJ-UHFFFAOYSA-N 168436 US9675591, SKA-19 Small conductance calcium-activated potassium channel protein 2 1.4e+4 7.35 25.00 C US Patent 10.7270/Q26T0JSP aid1794968 US9675591 PubChem, PC; Wulff, H; Coleman, N; Jenkins, DP The Regents of the University of California http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168436 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=342&target=Small+conductance+calcium-activated+potassium+channel+protein+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168436&enzyme=Small+conductance+calcium-activated+potassium+channel+protein+2&column=ki&startPg=0&Increment=50&submit=Search EUH 6GCQ 2735964 363891332 1 MSSCRYNGGVMRPLSNLSSSRRNLHEMDSEAQPLQPPASVVGGGGGASSPSAAAAASSSAPEIVVSKPEHNNSNNLALYGTGGGGSTGGGGGGGGGGGGSGHGSSSGTKSSKKKNQNIGYKLGHRRALFEKRKRLSDYALIFGMFGIVVMVIETELSWGAYDKASLYSLALKCLISLSTIILLGLIIVYHAREIQLFMVDNGADDWRIAMTYERIFFICLEILVCAIHPIPGNYTFTWTARLAFSYAPSTTTADVDIILSIPMFLRLYLIARVMLLHSKLFTDASSRSIGALNKINFNTRFVMKTLMTICPGTVLLVFSISLWIIAAWTVRACERYHDQQDVTSNFLGAMWLISITFLSIGYGDMVPNTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRVKNAAANVLRETWLIYKNTKLVKKIDHAKVRKHQRKFLQAIHQLRSVKMEQRKLNDQANTLVDLAKTQNIMYDMISDLNERSEDFEKRIVTLETKLETLIGSIHALPGLISQTIRQQQRDFIETQMENYDKHVTYNAERSRSSSRRRRSSSTAPPTSSESS 1QX7 Small conductance calcium-activated potassium channel protein 2 KCNN2_RAT P70604 51388912 CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CSSC[C@H](NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](C)N)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]3CSSC[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)CNC1=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(O)=O)NC3=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N2)C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O InChI=1S/C146H238N44O41S6/c1-16-77(14)115-142(230)163-62-109(196)165-87(40-43-111(198)199)125(213)171-89(42-45-113(202)203)127(215)183-100-65-232-233-66-101-137(225)172-88(41-44-112(200)201)126(214)177-95(56-75(10)11)130(218)181-99(64-192)134(222)187-102(67-234-236-69-104(185-123(211)83(169-135(100)223)31-21-23-47-148)139(227)188-114(76(12)13)143(231)190-51-27-35-106(190)141(229)173-90(116(151)204)57-80-36-38-81(193)39-37-80)136(224)170-85(33-25-49-159-145(154)155)122(210)180-98(63-191)133(221)176-92(53-72(4)5)119(207)162-61-110(197)166-93(54-73(6)7)128(216)175-91(52-71(2)3)118(206)161-60-108(195)164-82(30-20-22-46-147)120(208)184-105(140(228)189-115)70-237-235-68-103(186-131(219)96(174-117(205)78(15)149)58-79-28-18-17-19-29-79)138(226)179-97(59-107(150)194)132(220)178-94(55-74(8)9)129(217)168-84(32-24-48-158-144(152)153)121(209)167-86(124(212)182-101)34-26-50-160-146(156)157/h17-19,28-29,36-39,71-78,82-106,114-115,191-193H,16,20-27,30-35,40-70,147-149H2,1-15H3,(H2,150,194)(H2,151,204)(H,161,206)(H,162,207)(H,163,230)(H,164,195)(H,165,196)(H,166,197)(H,167,209)(H,168,217)(H,169,223)(H,170,224)(H,171,213)(H,172,225)(H,173,229)(H,174,205)(H,175,216)(H,176,221)(H,177,214)(H,178,220)(H,179,226)(H,180,210)(H,181,218)(H,182,212)(H,183,215)(H,184,208)(H,185,211)(H,186,219)(H,187,222)(H,188,227)(H,189,228)(H,198,199)(H,200,201)(H,202,203)(H4,152,153,158)(H4,154,155,159)(H4,156,157,160)/t77-,78-,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,114-,115-/m0/s1 QGQPJWMMJWVWFR-XMTLNCGUSA-N 50561183 CHEMBL4787693 Small conductance calcium-activated potassium channel protein 2 0.024000 ChEMBL 10.1021/acsmedchemlett.0c00300 10.7270/Q24B351Z 32832033 Mayorga-Flores, M; Chantôme, A; Melchor-Meneses, CM; Domingo, I; Titaux-Delgado, GA; Galindo-Murillo, R; Vandier, C; Del Río-Portilla, F Universidad Nacional Aut£noma de M£xico http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50561183 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=342&target=Small+conductance+calcium-activated+potassium+channel+protein+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50561183&enzyme=Small+conductance+calcium-activated+potassium+channel+protein+2&column=ki&startPg=0&Increment=50&submit=Search 162666814 461831575 C03803 1 MSSCRYNGGVMRPLSNLSSSRRNLHEMDSEAQPLQPPASVVGGGGGASSPSAAAAASSSAPEIVVSKPEHNNSNNLALYGTGGGGSTGGGGGGGGGGGGSGHGSSSGTKSSKKKNQNIGYKLGHRRALFEKRKRLSDYALIFGMFGIVVMVIETELSWGAYDKASLYSLALKCLISLSTIILLGLIIVYHAREIQLFMVDNGADDWRIAMTYERIFFICLEILVCAIHPIPGNYTFTWTARLAFSYAPSTTTADVDIILSIPMFLRLYLIARVMLLHSKLFTDASSRSIGALNKINFNTRFVMKTLMTICPGTVLLVFSISLWIIAAWTVRACERYHDQQDVTSNFLGAMWLISITFLSIGYGDMVPNTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRVKNAAANVLRETWLIYKNTKLVKKIDHAKVRKHQRKFLQAIHQLRSVKMEQRKLNDQANTLVDLAKTQNIMYDMISDLNERSEDFEKRIVTLETKLETLIGSIHALPGLISQTIRQQQRDFIETQMENYDKHVTYNAERSRSSSRRRRSSSTAPPTSSESS 1QX7 Small conductance calcium-activated potassium channel protein 2 KCNN2_RAT P70604 51388913 CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CSSC[C@H](NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](C)N)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCSC)C(=O)N[C@H]3CSSC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(O)=O)NC(=O)CNC1=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC3=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N2)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1c[nH]cn1)C(O)=O 50561184 CHEMBL4762592 Small conductance calcium-activated potassium channel protein 2 0.290000 ChEMBL 10.1021/acsmedchemlett.0c00300 10.7270/Q24B351Z 32832033 Mayorga-Flores, M; Chantôme, A; Melchor-Meneses, CM; Domingo, I; Titaux-Delgado, GA; Galindo-Murillo, R; Vandier, C; Del Río-Portilla, F Universidad Nacional Aut£noma de M£xico http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50561184 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=342&target=Small+conductance+calcium-activated+potassium+channel+protein+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50561184&enzyme=Small+conductance+calcium-activated+potassium+channel+protein+2&column=ki&startPg=0&Increment=50&submit=Search 162660250 461831576 C03803 1 MSSCRYNGGVMRPLSNLSSSRRNLHEMDSEAQPLQPPASVVGGGGGASSPSAAAAASSSAPEIVVSKPEHNNSNNLALYGTGGGGSTGGGGGGGGGGGGSGHGSSSGTKSSKKKNQNIGYKLGHRRALFEKRKRLSDYALIFGMFGIVVMVIETELSWGAYDKASLYSLALKCLISLSTIILLGLIIVYHAREIQLFMVDNGADDWRIAMTYERIFFICLEILVCAIHPIPGNYTFTWTARLAFSYAPSTTTADVDIILSIPMFLRLYLIARVMLLHSKLFTDASSRSIGALNKINFNTRFVMKTLMTICPGTVLLVFSISLWIIAAWTVRACERYHDQQDVTSNFLGAMWLISITFLSIGYGDMVPNTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRVKNAAANVLRETWLIYKNTKLVKKIDHAKVRKHQRKFLQAIHQLRSVKMEQRKLNDQANTLVDLAKTQNIMYDMISDLNERSEDFEKRIVTLETKLETLIGSIHALPGLISQTIRQQQRDFIETQMENYDKHVTYNAERSRSSSRRRRSSSTAPPTSSESS 1QX7 Small conductance calcium-activated potassium channel protein 2 KCNN2_RAT P70604 51388914 CC(C)C[C@@H]1NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]2CCCN2C(=O)[C@H](C)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]2CSSC[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](C)NC(=O)[C@H](CSSC[C@H](N)C(=O)N[C@@H](CC(N)=O)C(=O)N2)NC1=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(N)=O)[C@@H](C)O 50561185 CHEMBL4749661 Small conductance calcium-activated potassium channel protein 2 0.027000 ChEMBL 10.1021/acsmedchemlett.0c00300 10.7270/Q24B351Z 32832033 Mayorga-Flores, M; Chantôme, A; Melchor-Meneses, CM; Domingo, I; Titaux-Delgado, GA; Galindo-Murillo, R; Vandier, C; Del Río-Portilla, F Universidad Nacional Aut£noma de M£xico http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50561185 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=342&target=Small+conductance+calcium-activated+potassium+channel+protein+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50561185&enzyme=Small+conductance+calcium-activated+potassium+channel+protein+2&column=ki&startPg=0&Increment=50&submit=Search 162651436 461831577 1 MSSCRYNGGVMRPLSNLSSSRRNLHEMDSEAQPLQPPASVVGGGGGASSPSAAAAASSSAPEIVVSKPEHNNSNNLALYGTGGGGSTGGGGGGGGGGGGSGHGSSSGTKSSKKKNQNIGYKLGHRRALFEKRKRLSDYALIFGMFGIVVMVIETELSWGAYDKASLYSLALKCLISLSTIILLGLIIVYHAREIQLFMVDNGADDWRIAMTYERIFFICLEILVCAIHPIPGNYTFTWTARLAFSYAPSTTTADVDIILSIPMFLRLYLIARVMLLHSKLFTDASSRSIGALNKINFNTRFVMKTLMTICPGTVLLVFSISLWIIAAWTVRACERYHDQQDVTSNFLGAMWLISITFLSIGYGDMVPNTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRVKNAAANVLRETWLIYKNTKLVKKIDHAKVRKHQRKFLQAIHQLRSVKMEQRKLNDQANTLVDLAKTQNIMYDMISDLNERSEDFEKRIVTLETKLETLIGSIHALPGLISQTIRQQQRDFIETQMENYDKHVTYNAERSRSSSRRRRSSSTAPPTSSESS 1QX7 Small conductance calcium-activated potassium channel protein 2 KCNN2_RAT P70604 51443630 Cc1cc(C)n(n1)-c1cc(C)c(Nc2ccc(F)c(Cl)c2)nn1 InChI=1S/C16H15ClFN5/c1-9-6-15(23-11(3)7-10(2)22-23)20-21-16(9)19-12-4-5-14(18)13(17)8-12/h4-8H,1-3H3,(H,19,21) XIXDCZSXBCBMFJ-UHFFFAOYSA-N 50583231 CHEMBL5094656 Small conductance calcium-activated potassium channel protein 2 4320 ChEMBL 10.1021/acs.jmedchem.1c01473 10.7270/Q28919R5 34962403 El-Sayed, NS; Nam, YW; Egorova, PA; Nguyen, HM; Orfali, R; Rahman, MA; Yang, G; Wulff, H; Bezprozvanny, I; Parang, K; Zhang, M Chapman University School of Pharmacy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50583231 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=342&target=Small+conductance+calcium-activated+potassium+channel+protein+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50583231&enzyme=Small+conductance+calcium-activated+potassium+channel+protein+2&column=ki&startPg=0&Increment=50&submit=Search 166633436 476028236 1 MSSCRYNGGVMRPLSNLSSSRRNLHEMDSEAQPLQPPASVVGGGGGASSPSAAAAASSSAPEIVVSKPEHNNSNNLALYGTGGGGSTGGGGGGGGGGGGSGHGSSSGTKSSKKKNQNIGYKLGHRRALFEKRKRLSDYALIFGMFGIVVMVIETELSWGAYDKASLYSLALKCLISLSTIILLGLIIVYHAREIQLFMVDNGADDWRIAMTYERIFFICLEILVCAIHPIPGNYTFTWTARLAFSYAPSTTTADVDIILSIPMFLRLYLIARVMLLHSKLFTDASSRSIGALNKINFNTRFVMKTLMTICPGTVLLVFSISLWIIAAWTVRACERYHDQQDVTSNFLGAMWLISITFLSIGYGDMVPNTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRVKNAAANVLRETWLIYKNTKLVKKIDHAKVRKHQRKFLQAIHQLRSVKMEQRKLNDQANTLVDLAKTQNIMYDMISDLNERSEDFEKRIVTLETKLETLIGSIHALPGLISQTIRQQQRDFIETQMENYDKHVTYNAERSRSSSRRRRSSSTAPPTSSESS 1QX7 Small conductance calcium-activated potassium channel protein 2 KCNN2_RAT P70604 51443633 Cc1cc(C)n(n1)-c1nc(C)cc(Nc2cc(Cl)ccc2F)n1 InChI=1S/C16H15ClFN5/c1-9-7-15(20-14-8-12(17)4-5-13(14)18)21-16(19-9)23-11(3)6-10(2)22-23/h4-8H,1-3H3,(H,19,20,21) DWOQPNHOXLUTJZ-UHFFFAOYSA-N 50583213 CHEMBL5086997 Small conductance calcium-activated potassium channel protein 2 91 ChEMBL 10.1021/acs.jmedchem.1c01473 10.7270/Q28919R5 34962403 El-Sayed, NS; Nam, YW; Egorova, PA; Nguyen, HM; Orfali, R; Rahman, MA; Yang, G; Wulff, H; Bezprozvanny, I; Parang, K; Zhang, M Chapman University School of Pharmacy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50583213 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=342&target=Small+conductance+calcium-activated+potassium+channel+protein+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50583213&enzyme=Small+conductance+calcium-activated+potassium+channel+protein+2&column=ki&startPg=0&Increment=50&submit=Search 163196286 476028218 1 MSSCRYNGGVMRPLSNLSSSRRNLHEMDSEAQPLQPPASVVGGGGGASSPSAAAAASSSAPEIVVSKPEHNNSNNLALYGTGGGGSTGGGGGGGGGGGGSGHGSSSGTKSSKKKNQNIGYKLGHRRALFEKRKRLSDYALIFGMFGIVVMVIETELSWGAYDKASLYSLALKCLISLSTIILLGLIIVYHAREIQLFMVDNGADDWRIAMTYERIFFICLEILVCAIHPIPGNYTFTWTARLAFSYAPSTTTADVDIILSIPMFLRLYLIARVMLLHSKLFTDASSRSIGALNKINFNTRFVMKTLMTICPGTVLLVFSISLWIIAAWTVRACERYHDQQDVTSNFLGAMWLISITFLSIGYGDMVPNTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRVKNAAANVLRETWLIYKNTKLVKKIDHAKVRKHQRKFLQAIHQLRSVKMEQRKLNDQANTLVDLAKTQNIMYDMISDLNERSEDFEKRIVTLETKLETLIGSIHALPGLISQTIRQQQRDFIETQMENYDKHVTYNAERSRSSSRRRRSSSTAPPTSSESS 1QX7 Small conductance calcium-activated potassium channel protein 2 KCNN2_RAT P70604 51443634 Cc1cc(C)n(n1)-c1nc(C)cc(Nc2ccc(F)c(Cl)c2)n1 InChI=1S/C16H15ClFN5/c1-9-7-15(20-12-4-5-14(18)13(17)8-12)21-16(19-9)23-11(3)6-10(2)22-23/h4-8H,1-3H3,(H,19,20,21) LBSKGGZCJBHZET-UHFFFAOYSA-N 50583211 CHEMBL5078247 Small conductance calcium-activated potassium channel protein 2 110 ChEMBL 10.1021/acs.jmedchem.1c01473 10.7270/Q28919R5 34962403 El-Sayed, NS; Nam, YW; Egorova, PA; Nguyen, HM; Orfali, R; Rahman, MA; Yang, G; Wulff, H; Bezprozvanny, I; Parang, K; Zhang, M Chapman University School of Pharmacy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50583211 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=342&target=Small+conductance+calcium-activated+potassium+channel+protein+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50583211&enzyme=Small+conductance+calcium-activated+potassium+channel+protein+2&column=ki&startPg=0&Increment=50&submit=Search 16800218 476028216 1 MSSCRYNGGVMRPLSNLSSSRRNLHEMDSEAQPLQPPASVVGGGGGASSPSAAAAASSSAPEIVVSKPEHNNSNNLALYGTGGGGSTGGGGGGGGGGGGSGHGSSSGTKSSKKKNQNIGYKLGHRRALFEKRKRLSDYALIFGMFGIVVMVIETELSWGAYDKASLYSLALKCLISLSTIILLGLIIVYHAREIQLFMVDNGADDWRIAMTYERIFFICLEILVCAIHPIPGNYTFTWTARLAFSYAPSTTTADVDIILSIPMFLRLYLIARVMLLHSKLFTDASSRSIGALNKINFNTRFVMKTLMTICPGTVLLVFSISLWIIAAWTVRACERYHDQQDVTSNFLGAMWLISITFLSIGYGDMVPNTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRVKNAAANVLRETWLIYKNTKLVKKIDHAKVRKHQRKFLQAIHQLRSVKMEQRKLNDQANTLVDLAKTQNIMYDMISDLNERSEDFEKRIVTLETKLETLIGSIHALPGLISQTIRQQQRDFIETQMENYDKHVTYNAERSRSSSRRRRSSSTAPPTSSESS 1QX7 Small conductance calcium-activated potassium channel protein 2 KCNN2_RAT P70604 51443594 Cc1cc(C)n(n1)-c1nc(C)cc(N[C@@H]2CC[C@H](O)CC2)n1 InChI=1S/C16H23N5O/c1-10-9-15(18-13-4-6-14(22)7-5-13)19-16(17-10)21-12(3)8-11(2)20-21/h8-9,13-14,22H,4-7H2,1-3H3,(H,17,18,19)/t13-,14+ PYSDPLYCBSWWCT-OKILXGFUSA-N 50583196 CHEMBL5084004 Small conductance calcium-activated potassium channel protein 2 >100000 ChEMBL 10.1021/acs.jmedchem.1c01473 10.7270/Q28919R5 34962403 El-Sayed, NS; Nam, YW; Egorova, PA; Nguyen, HM; Orfali, R; Rahman, MA; Yang, G; Wulff, H; Bezprozvanny, I; Parang, K; Zhang, M Chapman University School of Pharmacy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50583196 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=342&target=Small+conductance+calcium-activated+potassium+channel+protein+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50583196&enzyme=Small+conductance+calcium-activated+potassium+channel+protein+2&column=ki&startPg=0&Increment=50&submit=Search 166627647 476028201 1 MSSCRYNGGVMRPLSNLSSSRRNLHEMDSEAQPLQPPASVVGGGGGASSPSAAAAASSSAPEIVVSKPEHNNSNNLALYGTGGGGSTGGGGGGGGGGGGSGHGSSSGTKSSKKKNQNIGYKLGHRRALFEKRKRLSDYALIFGMFGIVVMVIETELSWGAYDKASLYSLALKCLISLSTIILLGLIIVYHAREIQLFMVDNGADDWRIAMTYERIFFICLEILVCAIHPIPGNYTFTWTARLAFSYAPSTTTADVDIILSIPMFLRLYLIARVMLLHSKLFTDASSRSIGALNKINFNTRFVMKTLMTICPGTVLLVFSISLWIIAAWTVRACERYHDQQDVTSNFLGAMWLISITFLSIGYGDMVPNTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRVKNAAANVLRETWLIYKNTKLVKKIDHAKVRKHQRKFLQAIHQLRSVKMEQRKLNDQANTLVDLAKTQNIMYDMISDLNERSEDFEKRIVTLETKLETLIGSIHALPGLISQTIRQQQRDFIETQMENYDKHVTYNAERSRSSSRRRRSSSTAPPTSSESS 1QX7 Small conductance calcium-activated potassium channel protein 2 KCNN2_RAT P70604 51443595 Cc1cc(C)n(n1)-c1nc(C)cc(N[C@@H]2CC[C@H](N)CC2)n1 InChI=1S/C16H24N6/c1-10-9-15(19-14-6-4-13(17)5-7-14)20-16(18-10)22-12(3)8-11(2)21-22/h8-9,13-14H,4-7,17H2,1-3H3,(H,18,19,20)/t13-,14+ KNCSGEOLFXIXKO-OKILXGFUSA-N 50583197 CHEMBL5079951 Small conductance calcium-activated potassium channel protein 2 >100000 ChEMBL 10.1021/acs.jmedchem.1c01473 10.7270/Q28919R5 34962403 El-Sayed, NS; Nam, YW; Egorova, PA; Nguyen, HM; Orfali, R; Rahman, MA; Yang, G; Wulff, H; Bezprozvanny, I; Parang, K; Zhang, M Chapman University School of Pharmacy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50583197 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=342&target=Small+conductance+calcium-activated+potassium+channel+protein+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50583197&enzyme=Small+conductance+calcium-activated+potassium+channel+protein+2&column=ki&startPg=0&Increment=50&submit=Search 166627844 476028202 1 MSSCRYNGGVMRPLSNLSSSRRNLHEMDSEAQPLQPPASVVGGGGGASSPSAAAAASSSAPEIVVSKPEHNNSNNLALYGTGGGGSTGGGGGGGGGGGGSGHGSSSGTKSSKKKNQNIGYKLGHRRALFEKRKRLSDYALIFGMFGIVVMVIETELSWGAYDKASLYSLALKCLISLSTIILLGLIIVYHAREIQLFMVDNGADDWRIAMTYERIFFICLEILVCAIHPIPGNYTFTWTARLAFSYAPSTTTADVDIILSIPMFLRLYLIARVMLLHSKLFTDASSRSIGALNKINFNTRFVMKTLMTICPGTVLLVFSISLWIIAAWTVRACERYHDQQDVTSNFLGAMWLISITFLSIGYGDMVPNTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRVKNAAANVLRETWLIYKNTKLVKKIDHAKVRKHQRKFLQAIHQLRSVKMEQRKLNDQANTLVDLAKTQNIMYDMISDLNERSEDFEKRIVTLETKLETLIGSIHALPGLISQTIRQQQRDFIETQMENYDKHVTYNAERSRSSSRRRRSSSTAPPTSSESS 1QX7 Small conductance calcium-activated potassium channel protein 2 KCNN2_RAT P70604 51443596 Cc1cc(C)n(n1)-c1nc(C)cc(N[C@@H]2CC[C@H](CO)CC2)n1 InChI=1S/C17H25N5O/c1-11-9-16(19-15-6-4-14(10-23)5-7-15)20-17(18-11)22-13(3)8-12(2)21-22/h8-9,14-15,23H,4-7,10H2,1-3H3,(H,18,19,20)/t14-,15+ OGMHGBKJNAEHLF-GASCZTMLSA-N 50583198 CHEMBL5090455 Small conductance calcium-activated potassium channel protein 2 >100000 ChEMBL 10.1021/acs.jmedchem.1c01473 10.7270/Q28919R5 34962403 El-Sayed, NS; Nam, YW; Egorova, PA; Nguyen, HM; Orfali, R; Rahman, MA; Yang, G; Wulff, H; Bezprozvanny, I; Parang, K; Zhang, M Chapman University School of Pharmacy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50583198 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=342&target=Small+conductance+calcium-activated+potassium+channel+protein+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50583198&enzyme=Small+conductance+calcium-activated+potassium+channel+protein+2&column=ki&startPg=0&Increment=50&submit=Search 166635713 476028203 1 MSSCRYNGGVMRPLSNLSSSRRNLHEMDSEAQPLQPPASVVGGGGGASSPSAAAAASSSAPEIVVSKPEHNNSNNLALYGTGGGGSTGGGGGGGGGGGGSGHGSSSGTKSSKKKNQNIGYKLGHRRALFEKRKRLSDYALIFGMFGIVVMVIETELSWGAYDKASLYSLALKCLISLSTIILLGLIIVYHAREIQLFMVDNGADDWRIAMTYERIFFICLEILVCAIHPIPGNYTFTWTARLAFSYAPSTTTADVDIILSIPMFLRLYLIARVMLLHSKLFTDASSRSIGALNKINFNTRFVMKTLMTICPGTVLLVFSISLWIIAAWTVRACERYHDQQDVTSNFLGAMWLISITFLSIGYGDMVPNTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRVKNAAANVLRETWLIYKNTKLVKKIDHAKVRKHQRKFLQAIHQLRSVKMEQRKLNDQANTLVDLAKTQNIMYDMISDLNERSEDFEKRIVTLETKLETLIGSIHALPGLISQTIRQQQRDFIETQMENYDKHVTYNAERSRSSSRRRRSSSTAPPTSSESS 1QX7 Small conductance calcium-activated potassium channel protein 2 KCNN2_RAT P70604 51443597 CO[C@@H]1CC[C@@H](CC1)Nc1cc(C)nc(n1)-n1nc(C)cc1C InChI=1S/C17H25N5O/c1-11-10-16(19-14-5-7-15(23-4)8-6-14)20-17(18-11)22-13(3)9-12(2)21-22/h9-10,14-15H,5-8H2,1-4H3,(H,18,19,20)/t14-,15+ LCFTVJNDYDYVRA-GASCZTMLSA-N 50583199 CHEMBL5074647 Small conductance calcium-activated potassium channel protein 2 49720 ChEMBL 10.1021/acs.jmedchem.1c01473 10.7270/Q28919R5 34962403 El-Sayed, NS; Nam, YW; Egorova, PA; Nguyen, HM; Orfali, R; Rahman, MA; Yang, G; Wulff, H; Bezprozvanny, I; Parang, K; Zhang, M Chapman University School of Pharmacy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50583199 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=342&target=Small+conductance+calcium-activated+potassium+channel+protein+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50583199&enzyme=Small+conductance+calcium-activated+potassium+channel+protein+2&column=ki&startPg=0&Increment=50&submit=Search 166636554 476028204 1 MSSCRYNGGVMRPLSNLSSSRRNLHEMDSEAQPLQPPASVVGGGGGASSPSAAAAASSSAPEIVVSKPEHNNSNNLALYGTGGGGSTGGGGGGGGGGGGSGHGSSSGTKSSKKKNQNIGYKLGHRRALFEKRKRLSDYALIFGMFGIVVMVIETELSWGAYDKASLYSLALKCLISLSTIILLGLIIVYHAREIQLFMVDNGADDWRIAMTYERIFFICLEILVCAIHPIPGNYTFTWTARLAFSYAPSTTTADVDIILSIPMFLRLYLIARVMLLHSKLFTDASSRSIGALNKINFNTRFVMKTLMTICPGTVLLVFSISLWIIAAWTVRACERYHDQQDVTSNFLGAMWLISITFLSIGYGDMVPNTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRVKNAAANVLRETWLIYKNTKLVKKIDHAKVRKHQRKFLQAIHQLRSVKMEQRKLNDQANTLVDLAKTQNIMYDMISDLNERSEDFEKRIVTLETKLETLIGSIHALPGLISQTIRQQQRDFIETQMENYDKHVTYNAERSRSSSRRRRSSSTAPPTSSESS 1QX7 Small conductance calcium-activated potassium channel protein 2 KCNN2_RAT P70604 51443598 Cc1cc(C)n(n1)-c1nc(C)cc(N[C@@H]2CC[C@H](F)CC2)n1 InChI=1S/C16H22FN5/c1-10-9-15(19-14-6-4-13(17)5-7-14)20-16(18-10)22-12(3)8-11(2)21-22/h8-9,13-14H,4-7H2,1-3H3,(H,18,19,20)/t13-,14+ MGRQRDPJVVKWSJ-OKILXGFUSA-N 50583200 CHEMBL5093708 Small conductance calcium-activated potassium channel protein 2 >100000 ChEMBL 10.1021/acs.jmedchem.1c01473 10.7270/Q28919R5 34962403 El-Sayed, NS; Nam, YW; Egorova, PA; Nguyen, HM; Orfali, R; Rahman, MA; Yang, G; Wulff, H; Bezprozvanny, I; Parang, K; Zhang, M Chapman University School of Pharmacy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50583200 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=342&target=Small+conductance+calcium-activated+potassium+channel+protein+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50583200&enzyme=Small+conductance+calcium-activated+potassium+channel+protein+2&column=ki&startPg=0&Increment=50&submit=Search 166632774 476028205 1 MSSCRYNGGVMRPLSNLSSSRRNLHEMDSEAQPLQPPASVVGGGGGASSPSAAAAASSSAPEIVVSKPEHNNSNNLALYGTGGGGSTGGGGGGGGGGGGSGHGSSSGTKSSKKKNQNIGYKLGHRRALFEKRKRLSDYALIFGMFGIVVMVIETELSWGAYDKASLYSLALKCLISLSTIILLGLIIVYHAREIQLFMVDNGADDWRIAMTYERIFFICLEILVCAIHPIPGNYTFTWTARLAFSYAPSTTTADVDIILSIPMFLRLYLIARVMLLHSKLFTDASSRSIGALNKINFNTRFVMKTLMTICPGTVLLVFSISLWIIAAWTVRACERYHDQQDVTSNFLGAMWLISITFLSIGYGDMVPNTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRVKNAAANVLRETWLIYKNTKLVKKIDHAKVRKHQRKFLQAIHQLRSVKMEQRKLNDQANTLVDLAKTQNIMYDMISDLNERSEDFEKRIVTLETKLETLIGSIHALPGLISQTIRQQQRDFIETQMENYDKHVTYNAERSRSSSRRRRSSSTAPPTSSESS 1QX7 Small conductance calcium-activated potassium channel protein 2 KCNN2_RAT P70604 51443599 Cc1cc(C)n(n1)-c1nc(C)cc(N[C@H]2CC[C@H](CC2)[N+]([O-])=O)n1 InChI=1S/C16H22N6O2/c1-10-9-15(18-13-4-6-14(7-5-13)22(23)24)19-16(17-10)21-12(3)8-11(2)20-21/h8-9,13-14H,4-7H2,1-3H3,(H,17,18,19)/t13-,14+ XQMPVWWYJURNSC-OKILXGFUSA-N 50583201 CHEMBL5080805 Small conductance calcium-activated potassium channel protein 2 >100000 ChEMBL 10.1021/acs.jmedchem.1c01473 10.7270/Q28919R5 34962403 El-Sayed, NS; Nam, YW; Egorova, PA; Nguyen, HM; Orfali, R; Rahman, MA; Yang, G; Wulff, H; Bezprozvanny, I; Parang, K; Zhang, M Chapman University School of Pharmacy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50583201 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=342&target=Small+conductance+calcium-activated+potassium+channel+protein+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50583201&enzyme=Small+conductance+calcium-activated+potassium+channel+protein+2&column=ki&startPg=0&Increment=50&submit=Search 166629084 476028206 1 MSSCRYNGGVMRPLSNLSSSRRNLHEMDSEAQPLQPPASVVGGGGGASSPSAAAAASSSAPEIVVSKPEHNNSNNLALYGTGGGGSTGGGGGGGGGGGGSGHGSSSGTKSSKKKNQNIGYKLGHRRALFEKRKRLSDYALIFGMFGIVVMVIETELSWGAYDKASLYSLALKCLISLSTIILLGLIIVYHAREIQLFMVDNGADDWRIAMTYERIFFICLEILVCAIHPIPGNYTFTWTARLAFSYAPSTTTADVDIILSIPMFLRLYLIARVMLLHSKLFTDASSRSIGALNKINFNTRFVMKTLMTICPGTVLLVFSISLWIIAAWTVRACERYHDQQDVTSNFLGAMWLISITFLSIGYGDMVPNTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRVKNAAANVLRETWLIYKNTKLVKKIDHAKVRKHQRKFLQAIHQLRSVKMEQRKLNDQANTLVDLAKTQNIMYDMISDLNERSEDFEKRIVTLETKLETLIGSIHALPGLISQTIRQQQRDFIETQMENYDKHVTYNAERSRSSSRRRRSSSTAPPTSSESS 1QX7 Small conductance calcium-activated potassium channel protein 2 KCNN2_RAT P70604 51443600 Cc1cc(C)n(n1)-c1nc(C)cc(NC2CCCCC2)n1 InChI=1S/C16H23N5/c1-11-10-15(18-14-7-5-4-6-8-14)19-16(17-11)21-13(3)9-12(2)20-21/h9-10,14H,4-8H2,1-3H3,(H,17,18,19) USEMRPYUFJNFQN-UHFFFAOYSA-N 50275157 CHEMBL453730::N-cyclohexyl-2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-methylpyrimidin-4-amine Small conductance calcium-activated potassium channel protein 2 7480 ChEMBL 10.1021/acs.jmedchem.1c01473 10.7270/Q28919R5 34962403 El-Sayed, NS; Nam, YW; Egorova, PA; Nguyen, HM; Orfali, R; Rahman, MA; Yang, G; Wulff, H; Bezprozvanny, I; Parang, K; Zhang, M Chapman University School of Pharmacy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50275157 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=342&target=Small+conductance+calcium-activated+potassium+channel+protein+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50275157&enzyme=Small+conductance+calcium-activated+potassium+channel+protein+2&column=ki&startPg=0&Increment=50&submit=Search 909822 104118715 CHEMBL453730 2323 ZINC00492516 1 MSSCRYNGGVMRPLSNLSSSRRNLHEMDSEAQPLQPPASVVGGGGGASSPSAAAAASSSAPEIVVSKPEHNNSNNLALYGTGGGGSTGGGGGGGGGGGGSGHGSSSGTKSSKKKNQNIGYKLGHRRALFEKRKRLSDYALIFGMFGIVVMVIETELSWGAYDKASLYSLALKCLISLSTIILLGLIIVYHAREIQLFMVDNGADDWRIAMTYERIFFICLEILVCAIHPIPGNYTFTWTARLAFSYAPSTTTADVDIILSIPMFLRLYLIARVMLLHSKLFTDASSRSIGALNKINFNTRFVMKTLMTICPGTVLLVFSISLWIIAAWTVRACERYHDQQDVTSNFLGAMWLISITFLSIGYGDMVPNTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRVKNAAANVLRETWLIYKNTKLVKKIDHAKVRKHQRKFLQAIHQLRSVKMEQRKLNDQANTLVDLAKTQNIMYDMISDLNERSEDFEKRIVTLETKLETLIGSIHALPGLISQTIRQQQRDFIETQMENYDKHVTYNAERSRSSSRRRRSSSTAPPTSSESS 1QX7 Small conductance calcium-activated potassium channel protein 2 KCNN2_RAT P70604 51443601 Cc1cc(C)n(n1)-c1nc(C)cc(NCCc2ccc(cc2)[N+]([O-])=O)n1 InChI=1S/C18H20N6O2/c1-12-11-17(21-18(20-12)23-14(3)10-13(2)22-23)19-9-8-15-4-6-16(7-5-15)24(25)26/h4-7,10-11H,8-9H2,1-3H3,(H,19,20,21) WEOHZKHGAWZHDV-UHFFFAOYSA-N 50583202 CHEMBL5083279 Small conductance calcium-activated potassium channel protein 2 >100000 ChEMBL 10.1021/acs.jmedchem.1c01473 10.7270/Q28919R5 34962403 El-Sayed, NS; Nam, YW; Egorova, PA; Nguyen, HM; Orfali, R; Rahman, MA; Yang, G; Wulff, H; Bezprozvanny, I; Parang, K; Zhang, M Chapman University School of Pharmacy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50583202 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=342&target=Small+conductance+calcium-activated+potassium+channel+protein+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50583202&enzyme=Small+conductance+calcium-activated+potassium+channel+protein+2&column=ki&startPg=0&Increment=50&submit=Search 166630266 476028207 1 MSSCRYNGGVMRPLSNLSSSRRNLHEMDSEAQPLQPPASVVGGGGGASSPSAAAAASSSAPEIVVSKPEHNNSNNLALYGTGGGGSTGGGGGGGGGGGGSGHGSSSGTKSSKKKNQNIGYKLGHRRALFEKRKRLSDYALIFGMFGIVVMVIETELSWGAYDKASLYSLALKCLISLSTIILLGLIIVYHAREIQLFMVDNGADDWRIAMTYERIFFICLEILVCAIHPIPGNYTFTWTARLAFSYAPSTTTADVDIILSIPMFLRLYLIARVMLLHSKLFTDASSRSIGALNKINFNTRFVMKTLMTICPGTVLLVFSISLWIIAAWTVRACERYHDQQDVTSNFLGAMWLISITFLSIGYGDMVPNTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRVKNAAANVLRETWLIYKNTKLVKKIDHAKVRKHQRKFLQAIHQLRSVKMEQRKLNDQANTLVDLAKTQNIMYDMISDLNERSEDFEKRIVTLETKLETLIGSIHALPGLISQTIRQQQRDFIETQMENYDKHVTYNAERSRSSSRRRRSSSTAPPTSSESS 1QX7 Small conductance calcium-activated potassium channel protein 2 KCNN2_RAT P70604 51443602 COc1cc2nc(Nc3cc(C)nc(n3)-n3nc(C)cc3C)[nH]c2cc1OC InChI=1S/C19H21N7O2/c1-10-7-17(24-19(20-10)26-12(3)6-11(2)25-26)23-18-21-13-8-15(27-4)16(28-5)9-14(13)22-18/h6-9H,1-5H3,(H2,20,21,22,23,24) QXZWZORWYJKSIO-UHFFFAOYSA-N 50583203 CHEMBL5081876 Small conductance calcium-activated potassium channel protein 2 >100000 ChEMBL 10.1021/acs.jmedchem.1c01473 10.7270/Q28919R5 34962403 El-Sayed, NS; Nam, YW; Egorova, PA; Nguyen, HM; Orfali, R; Rahman, MA; Yang, G; Wulff, H; Bezprozvanny, I; Parang, K; Zhang, M Chapman University School of Pharmacy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50583203 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=342&target=Small+conductance+calcium-activated+potassium+channel+protein+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50583203&enzyme=Small+conductance+calcium-activated+potassium+channel+protein+2&column=ki&startPg=0&Increment=50&submit=Search 166627456 476028208 1 MSSCRYNGGVMRPLSNLSSSRRNLHEMDSEAQPLQPPASVVGGGGGASSPSAAAAASSSAPEIVVSKPEHNNSNNLALYGTGGGGSTGGGGGGGGGGGGSGHGSSSGTKSSKKKNQNIGYKLGHRRALFEKRKRLSDYALIFGMFGIVVMVIETELSWGAYDKASLYSLALKCLISLSTIILLGLIIVYHAREIQLFMVDNGADDWRIAMTYERIFFICLEILVCAIHPIPGNYTFTWTARLAFSYAPSTTTADVDIILSIPMFLRLYLIARVMLLHSKLFTDASSRSIGALNKINFNTRFVMKTLMTICPGTVLLVFSISLWIIAAWTVRACERYHDQQDVTSNFLGAMWLISITFLSIGYGDMVPNTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRVKNAAANVLRETWLIYKNTKLVKKIDHAKVRKHQRKFLQAIHQLRSVKMEQRKLNDQANTLVDLAKTQNIMYDMISDLNERSEDFEKRIVTLETKLETLIGSIHALPGLISQTIRQQQRDFIETQMENYDKHVTYNAERSRSSSRRRRSSSTAPPTSSESS 1QX7 Small conductance calcium-activated potassium channel protein 2 KCNN2_RAT P70604 51443603 Cc1cc(C)n(n1)-c1nc(C)cc(N[C@@H](Cc2ccc(cc2)C#N)C(O)=O)n1 InChI=1S/C20H20N6O2/c1-12-9-18(24-20(22-12)26-14(3)8-13(2)25-26)23-17(19(27)28)10-15-4-6-16(11-21)7-5-15/h4-9,17H,10H2,1-3H3,(H,27,28)(H,22,23,24)/t17-/m0/s1 QWYABDVYFSNDGE-KRWDZBQOSA-N 50583204 CHEMBL5075501 Small conductance calcium-activated potassium channel protein 2 >100000 ChEMBL 10.1021/acs.jmedchem.1c01473 10.7270/Q28919R5 34962403 El-Sayed, NS; Nam, YW; Egorova, PA; Nguyen, HM; Orfali, R; Rahman, MA; Yang, G; Wulff, H; Bezprozvanny, I; Parang, K; Zhang, M Chapman University School of Pharmacy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50583204 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=342&target=Small+conductance+calcium-activated+potassium+channel+protein+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50583204&enzyme=Small+conductance+calcium-activated+potassium+channel+protein+2&column=ki&startPg=0&Increment=50&submit=Search 166626299 476028209 1 MSSCRYNGGVMRPLSNLSSSRRNLHEMDSEAQPLQPPASVVGGGGGASSPSAAAAASSSAPEIVVSKPEHNNSNNLALYGTGGGGSTGGGGGGGGGGGGSGHGSSSGTKSSKKKNQNIGYKLGHRRALFEKRKRLSDYALIFGMFGIVVMVIETELSWGAYDKASLYSLALKCLISLSTIILLGLIIVYHAREIQLFMVDNGADDWRIAMTYERIFFICLEILVCAIHPIPGNYTFTWTARLAFSYAPSTTTADVDIILSIPMFLRLYLIARVMLLHSKLFTDASSRSIGALNKINFNTRFVMKTLMTICPGTVLLVFSISLWIIAAWTVRACERYHDQQDVTSNFLGAMWLISITFLSIGYGDMVPNTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRVKNAAANVLRETWLIYKNTKLVKKIDHAKVRKHQRKFLQAIHQLRSVKMEQRKLNDQANTLVDLAKTQNIMYDMISDLNERSEDFEKRIVTLETKLETLIGSIHALPGLISQTIRQQQRDFIETQMENYDKHVTYNAERSRSSSRRRRSSSTAPPTSSESS 1QX7 Small conductance calcium-activated potassium channel protein 2 KCNN2_RAT P70604 51443604 Cc1cc(C)n(n1)-c1nc(C)cc(N[C@@H](Cc2ccc(O)cc2)C(O)=O)n1 InChI=1S/C19H21N5O3/c1-11-9-17(22-19(20-11)24-13(3)8-12(2)23-24)21-16(18(26)27)10-14-4-6-15(25)7-5-14/h4-9,16,25H,10H2,1-3H3,(H,26,27)(H,20,21,22)/t16-/m0/s1 YBDTUMCYWVGLIK-INIZCTEOSA-N 50583205 CHEMBL5069418 Small conductance calcium-activated potassium channel protein 2 >100000 ChEMBL 10.1021/acs.jmedchem.1c01473 10.7270/Q28919R5 34962403 El-Sayed, NS; Nam, YW; Egorova, PA; Nguyen, HM; Orfali, R; Rahman, MA; Yang, G; Wulff, H; Bezprozvanny, I; Parang, K; Zhang, M Chapman University School of Pharmacy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50583205 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=342&target=Small+conductance+calcium-activated+potassium+channel+protein+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50583205&enzyme=Small+conductance+calcium-activated+potassium+channel+protein+2&column=ki&startPg=0&Increment=50&submit=Search 166625811 476028210 1 MSSCRYNGGVMRPLSNLSSSRRNLHEMDSEAQPLQPPASVVGGGGGASSPSAAAAASSSAPEIVVSKPEHNNSNNLALYGTGGGGSTGGGGGGGGGGGGSGHGSSSGTKSSKKKNQNIGYKLGHRRALFEKRKRLSDYALIFGMFGIVVMVIETELSWGAYDKASLYSLALKCLISLSTIILLGLIIVYHAREIQLFMVDNGADDWRIAMTYERIFFICLEILVCAIHPIPGNYTFTWTARLAFSYAPSTTTADVDIILSIPMFLRLYLIARVMLLHSKLFTDASSRSIGALNKINFNTRFVMKTLMTICPGTVLLVFSISLWIIAAWTVRACERYHDQQDVTSNFLGAMWLISITFLSIGYGDMVPNTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRVKNAAANVLRETWLIYKNTKLVKKIDHAKVRKHQRKFLQAIHQLRSVKMEQRKLNDQANTLVDLAKTQNIMYDMISDLNERSEDFEKRIVTLETKLETLIGSIHALPGLISQTIRQQQRDFIETQMENYDKHVTYNAERSRSSSRRRRSSSTAPPTSSESS 1QX7 Small conductance calcium-activated potassium channel protein 2 KCNN2_RAT P70604 51443605 Cc1cc(C)n(n1)-c1nc(C)cc(N[C@@H](Cc2ccc(F)c(F)c2)C(O)=O)n1 InChI=1S/C19H19F2N5O2/c1-10-7-17(24-19(22-10)26-12(3)6-11(2)25-26)23-16(18(27)28)9-13-4-5-14(20)15(21)8-13/h4-8,16H,9H2,1-3H3,(H,27,28)(H,22,23,24)/t16-/m0/s1 TVSJKOJJPODLLA-INIZCTEOSA-N 50583206 CHEMBL5079218 Small conductance calcium-activated potassium channel protein 2 >100000 ChEMBL 10.1021/acs.jmedchem.1c01473 10.7270/Q28919R5 34962403 El-Sayed, NS; Nam, YW; Egorova, PA; Nguyen, HM; Orfali, R; Rahman, MA; Yang, G; Wulff, H; Bezprozvanny, I; Parang, K; Zhang, M Chapman University School of Pharmacy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50583206 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=342&target=Small+conductance+calcium-activated+potassium+channel+protein+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50583206&enzyme=Small+conductance+calcium-activated+potassium+channel+protein+2&column=ki&startPg=0&Increment=50&submit=Search 166628050 476028211 1 MSSCRYNGGVMRPLSNLSSSRRNLHEMDSEAQPLQPPASVVGGGGGASSPSAAAAASSSAPEIVVSKPEHNNSNNLALYGTGGGGSTGGGGGGGGGGGGSGHGSSSGTKSSKKKNQNIGYKLGHRRALFEKRKRLSDYALIFGMFGIVVMVIETELSWGAYDKASLYSLALKCLISLSTIILLGLIIVYHAREIQLFMVDNGADDWRIAMTYERIFFICLEILVCAIHPIPGNYTFTWTARLAFSYAPSTTTADVDIILSIPMFLRLYLIARVMLLHSKLFTDASSRSIGALNKINFNTRFVMKTLMTICPGTVLLVFSISLWIIAAWTVRACERYHDQQDVTSNFLGAMWLISITFLSIGYGDMVPNTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRVKNAAANVLRETWLIYKNTKLVKKIDHAKVRKHQRKFLQAIHQLRSVKMEQRKLNDQANTLVDLAKTQNIMYDMISDLNERSEDFEKRIVTLETKLETLIGSIHALPGLISQTIRQQQRDFIETQMENYDKHVTYNAERSRSSSRRRRSSSTAPPTSSESS 1QX7 Small conductance calcium-activated potassium channel protein 2 KCNN2_RAT P70604 51443606 Cc1cc(C)n(n1)-c1nc(C)cc(Nc2ccc(S)cc2)n1 InChI=1S/C16H17N5S/c1-10-9-15(18-13-4-6-14(22)7-5-13)19-16(17-10)21-12(3)8-11(2)20-21/h4-9,22H,1-3H3,(H,17,18,19) XOIDQLMNLUVGJU-UHFFFAOYSA-N 50583207 CHEMBL5088689 Small conductance calcium-activated potassium channel protein 2 >100000 ChEMBL 10.1021/acs.jmedchem.1c01473 10.7270/Q28919R5 34962403 El-Sayed, NS; Nam, YW; Egorova, PA; Nguyen, HM; Orfali, R; Rahman, MA; Yang, G; Wulff, H; Bezprozvanny, I; Parang, K; Zhang, M Chapman University School of Pharmacy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50583207 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=342&target=Small+conductance+calcium-activated+potassium+channel+protein+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50583207&enzyme=Small+conductance+calcium-activated+potassium+channel+protein+2&column=ki&startPg=0&Increment=50&submit=Search 166634314 476028212 1 MSSCRYNGGVMRPLSNLSSSRRNLHEMDSEAQPLQPPASVVGGGGGASSPSAAAAASSSAPEIVVSKPEHNNSNNLALYGTGGGGSTGGGGGGGGGGGGSGHGSSSGTKSSKKKNQNIGYKLGHRRALFEKRKRLSDYALIFGMFGIVVMVIETELSWGAYDKASLYSLALKCLISLSTIILLGLIIVYHAREIQLFMVDNGADDWRIAMTYERIFFICLEILVCAIHPIPGNYTFTWTARLAFSYAPSTTTADVDIILSIPMFLRLYLIARVMLLHSKLFTDASSRSIGALNKINFNTRFVMKTLMTICPGTVLLVFSISLWIIAAWTVRACERYHDQQDVTSNFLGAMWLISITFLSIGYGDMVPNTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRVKNAAANVLRETWLIYKNTKLVKKIDHAKVRKHQRKFLQAIHQLRSVKMEQRKLNDQANTLVDLAKTQNIMYDMISDLNERSEDFEKRIVTLETKLETLIGSIHALPGLISQTIRQQQRDFIETQMENYDKHVTYNAERSRSSSRRRRSSSTAPPTSSESS 1QX7 Small conductance calcium-activated potassium channel protein 2 KCNN2_RAT P70604 51443607 Cc1cc(C)n(n1)-c1nc(C)cc(Nc2ccc(cc2)[N+]([O-])=O)n1 InChI=1S/C16H16N6O2/c1-10-9-15(18-13-4-6-14(7-5-13)22(23)24)19-16(17-10)21-12(3)8-11(2)20-21/h4-9H,1-3H3,(H,17,18,19) PMTSIKPZCPWBOM-UHFFFAOYSA-N 50583208 CHEMBL5089976 Small conductance calcium-activated potassium channel protein 2 >100000 ChEMBL 10.1021/acs.jmedchem.1c01473 10.7270/Q28919R5 34962403 El-Sayed, NS; Nam, YW; Egorova, PA; Nguyen, HM; Orfali, R; Rahman, MA; Yang, G; Wulff, H; Bezprozvanny, I; Parang, K; Zhang, M Chapman University School of Pharmacy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50583208 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=342&target=Small+conductance+calcium-activated+potassium+channel+protein+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50583208&enzyme=Small+conductance+calcium-activated+potassium+channel+protein+2&column=ki&startPg=0&Increment=50&submit=Search 166631436 476028213 1 MSSCRYNGGVMRPLSNLSSSRRNLHEMDSEAQPLQPPASVVGGGGGASSPSAAAAASSSAPEIVVSKPEHNNSNNLALYGTGGGGSTGGGGGGGGGGGGSGHGSSSGTKSSKKKNQNIGYKLGHRRALFEKRKRLSDYALIFGMFGIVVMVIETELSWGAYDKASLYSLALKCLISLSTIILLGLIIVYHAREIQLFMVDNGADDWRIAMTYERIFFICLEILVCAIHPIPGNYTFTWTARLAFSYAPSTTTADVDIILSIPMFLRLYLIARVMLLHSKLFTDASSRSIGALNKINFNTRFVMKTLMTICPGTVLLVFSISLWIIAAWTVRACERYHDQQDVTSNFLGAMWLISITFLSIGYGDMVPNTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRVKNAAANVLRETWLIYKNTKLVKKIDHAKVRKHQRKFLQAIHQLRSVKMEQRKLNDQANTLVDLAKTQNIMYDMISDLNERSEDFEKRIVTLETKLETLIGSIHALPGLISQTIRQQQRDFIETQMENYDKHVTYNAERSRSSSRRRRSSSTAPPTSSESS 1QX7 Small conductance calcium-activated potassium channel protein 2 KCNN2_RAT P70604 51443608 Cc1cc(C)n(n1)-c1nc(C)cc(Nc2cccc(F)c2F)n1 InChI=1S/C16H15F2N5/c1-9-8-14(20-13-6-4-5-12(17)15(13)18)21-16(19-9)23-11(3)7-10(2)22-23/h4-8H,1-3H3,(H,19,20,21) QLFQGWLQZFUQTJ-UHFFFAOYSA-N 50583209 CHEMBL5082158 Small conductance calcium-activated potassium channel protein 2 5030 ChEMBL 10.1021/acs.jmedchem.1c01473 10.7270/Q28919R5 34962403 El-Sayed, NS; Nam, YW; Egorova, PA; Nguyen, HM; Orfali, R; Rahman, MA; Yang, G; Wulff, H; Bezprozvanny, I; Parang, K; Zhang, M Chapman University School of Pharmacy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50583209 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=342&target=Small+conductance+calcium-activated+potassium+channel+protein+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50583209&enzyme=Small+conductance+calcium-activated+potassium+channel+protein+2&column=ki&startPg=0&Increment=50&submit=Search 166630239 476028214 1 MSSCRYNGGVMRPLSNLSSSRRNLHEMDSEAQPLQPPASVVGGGGGASSPSAAAAASSSAPEIVVSKPEHNNSNNLALYGTGGGGSTGGGGGGGGGGGGSGHGSSSGTKSSKKKNQNIGYKLGHRRALFEKRKRLSDYALIFGMFGIVVMVIETELSWGAYDKASLYSLALKCLISLSTIILLGLIIVYHAREIQLFMVDNGADDWRIAMTYERIFFICLEILVCAIHPIPGNYTFTWTARLAFSYAPSTTTADVDIILSIPMFLRLYLIARVMLLHSKLFTDASSRSIGALNKINFNTRFVMKTLMTICPGTVLLVFSISLWIIAAWTVRACERYHDQQDVTSNFLGAMWLISITFLSIGYGDMVPNTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRVKNAAANVLRETWLIYKNTKLVKKIDHAKVRKHQRKFLQAIHQLRSVKMEQRKLNDQANTLVDLAKTQNIMYDMISDLNERSEDFEKRIVTLETKLETLIGSIHALPGLISQTIRQQQRDFIETQMENYDKHVTYNAERSRSSSRRRRSSSTAPPTSSESS 1QX7 Small conductance calcium-activated potassium channel protein 2 KCNN2_RAT P70604 51443609 Cc1cc(C)n(n1)-c1nc(C)cc(Nc2cc(F)ccc2F)n1 InChI=1S/C16H15F2N5/c1-9-7-15(20-14-8-12(17)4-5-13(14)18)21-16(19-9)23-11(3)6-10(2)22-23/h4-8H,1-3H3,(H,19,20,21) NNXPSYWMJCRMDJ-UHFFFAOYSA-N 50583210 CHEMBL5074700 Small conductance calcium-activated potassium channel protein 2 1890 ChEMBL 10.1021/acs.jmedchem.1c01473 10.7270/Q28919R5 34962403 El-Sayed, NS; Nam, YW; Egorova, PA; Nguyen, HM; Orfali, R; Rahman, MA; Yang, G; Wulff, H; Bezprozvanny, I; Parang, K; Zhang, M Chapman University School of Pharmacy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50583210 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=342&target=Small+conductance+calcium-activated+potassium+channel+protein+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50583210&enzyme=Small+conductance+calcium-activated+potassium+channel+protein+2&column=ki&startPg=0&Increment=50&submit=Search 166636582 476028215 1 MSSCRYNGGVMRPLSNLSSSRRNLHEMDSEAQPLQPPASVVGGGGGASSPSAAAAASSSAPEIVVSKPEHNNSNNLALYGTGGGGSTGGGGGGGGGGGGSGHGSSSGTKSSKKKNQNIGYKLGHRRALFEKRKRLSDYALIFGMFGIVVMVIETELSWGAYDKASLYSLALKCLISLSTIILLGLIIVYHAREIQLFMVDNGADDWRIAMTYERIFFICLEILVCAIHPIPGNYTFTWTARLAFSYAPSTTTADVDIILSIPMFLRLYLIARVMLLHSKLFTDASSRSIGALNKINFNTRFVMKTLMTICPGTVLLVFSISLWIIAAWTVRACERYHDQQDVTSNFLGAMWLISITFLSIGYGDMVPNTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRVKNAAANVLRETWLIYKNTKLVKKIDHAKVRKHQRKFLQAIHQLRSVKMEQRKLNDQANTLVDLAKTQNIMYDMISDLNERSEDFEKRIVTLETKLETLIGSIHALPGLISQTIRQQQRDFIETQMENYDKHVTYNAERSRSSSRRRRSSSTAPPTSSESS 1QX7 Small conductance calcium-activated potassium channel protein 2 KCNN2_RAT P70604 51443610 Cc1cc(C)n(n1)-c1nc(C)cc(Nc2ccc(F)c(Cl)c2)n1 InChI=1S/C16H15ClFN5/c1-9-7-15(20-12-4-5-14(18)13(17)8-12)21-16(19-9)23-11(3)6-10(2)22-23/h4-8H,1-3H3,(H,19,20,21) LBSKGGZCJBHZET-UHFFFAOYSA-N 50583211 CHEMBL5078247 Small conductance calcium-activated potassium channel protein 2 990 ChEMBL 10.1021/acs.jmedchem.1c01473 10.7270/Q28919R5 34962403 El-Sayed, NS; Nam, YW; Egorova, PA; Nguyen, HM; Orfali, R; Rahman, MA; Yang, G; Wulff, H; Bezprozvanny, I; Parang, K; Zhang, M Chapman University School of Pharmacy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50583211 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=342&target=Small+conductance+calcium-activated+potassium+channel+protein+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50583211&enzyme=Small+conductance+calcium-activated+potassium+channel+protein+2&column=ki&startPg=0&Increment=50&submit=Search 16800218 476028216 1 MSSCRYNGGVMRPLSNLSSSRRNLHEMDSEAQPLQPPASVVGGGGGASSPSAAAAASSSAPEIVVSKPEHNNSNNLALYGTGGGGSTGGGGGGGGGGGGSGHGSSSGTKSSKKKNQNIGYKLGHRRALFEKRKRLSDYALIFGMFGIVVMVIETELSWGAYDKASLYSLALKCLISLSTIILLGLIIVYHAREIQLFMVDNGADDWRIAMTYERIFFICLEILVCAIHPIPGNYTFTWTARLAFSYAPSTTTADVDIILSIPMFLRLYLIARVMLLHSKLFTDASSRSIGALNKINFNTRFVMKTLMTICPGTVLLVFSISLWIIAAWTVRACERYHDQQDVTSNFLGAMWLISITFLSIGYGDMVPNTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRVKNAAANVLRETWLIYKNTKLVKKIDHAKVRKHQRKFLQAIHQLRSVKMEQRKLNDQANTLVDLAKTQNIMYDMISDLNERSEDFEKRIVTLETKLETLIGSIHALPGLISQTIRQQQRDFIETQMENYDKHVTYNAERSRSSSRRRRSSSTAPPTSSESS 1QX7 Small conductance calcium-activated potassium channel protein 2 KCNN2_RAT P70604 51443611 Cc1cc(C)n(n1)-c1nc(C)cc(Nc2ccc(Cl)cc2F)n1 InChI=1S/C16H15ClFN5/c1-9-7-15(20-14-5-4-12(17)8-13(14)18)21-16(19-9)23-11(3)6-10(2)22-23/h4-8H,1-3H3,(H,19,20,21) XAANKJBRZWMODN-UHFFFAOYSA-N 50583212 CHEMBL5076878 Small conductance calcium-activated potassium channel protein 2 1990 ChEMBL 10.1021/acs.jmedchem.1c01473 10.7270/Q28919R5 34962403 El-Sayed, NS; Nam, YW; Egorova, PA; Nguyen, HM; Orfali, R; Rahman, MA; Yang, G; Wulff, H; Bezprozvanny, I; Parang, K; Zhang, M Chapman University School of Pharmacy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50583212 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=342&target=Small+conductance+calcium-activated+potassium+channel+protein+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50583212&enzyme=Small+conductance+calcium-activated+potassium+channel+protein+2&column=ki&startPg=0&Increment=50&submit=Search 166626048 476028217 1 MSSCRYNGGVMRPLSNLSSSRRNLHEMDSEAQPLQPPASVVGGGGGASSPSAAAAASSSAPEIVVSKPEHNNSNNLALYGTGGGGSTGGGGGGGGGGGGSGHGSSSGTKSSKKKNQNIGYKLGHRRALFEKRKRLSDYALIFGMFGIVVMVIETELSWGAYDKASLYSLALKCLISLSTIILLGLIIVYHAREIQLFMVDNGADDWRIAMTYERIFFICLEILVCAIHPIPGNYTFTWTARLAFSYAPSTTTADVDIILSIPMFLRLYLIARVMLLHSKLFTDASSRSIGALNKINFNTRFVMKTLMTICPGTVLLVFSISLWIIAAWTVRACERYHDQQDVTSNFLGAMWLISITFLSIGYGDMVPNTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRVKNAAANVLRETWLIYKNTKLVKKIDHAKVRKHQRKFLQAIHQLRSVKMEQRKLNDQANTLVDLAKTQNIMYDMISDLNERSEDFEKRIVTLETKLETLIGSIHALPGLISQTIRQQQRDFIETQMENYDKHVTYNAERSRSSSRRRRSSSTAPPTSSESS 1QX7 Small conductance calcium-activated potassium channel protein 2 KCNN2_RAT P70604 51443612 Cc1cc(C)n(n1)-c1nc(C)cc(Nc2cc(Cl)ccc2F)n1 InChI=1S/C16H15ClFN5/c1-9-7-15(20-14-8-12(17)4-5-13(14)18)21-16(19-9)23-11(3)6-10(2)22-23/h4-8H,1-3H3,(H,19,20,21) DWOQPNHOXLUTJZ-UHFFFAOYSA-N 50583213 CHEMBL5086997 Small conductance calcium-activated potassium channel protein 2 640 ChEMBL 10.1021/acs.jmedchem.1c01473 10.7270/Q28919R5 34962403 El-Sayed, NS; Nam, YW; Egorova, PA; Nguyen, HM; Orfali, R; Rahman, MA; Yang, G; Wulff, H; Bezprozvanny, I; Parang, K; Zhang, M Chapman University School of Pharmacy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50583213 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=342&target=Small+conductance+calcium-activated+potassium+channel+protein+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50583213&enzyme=Small+conductance+calcium-activated+potassium+channel+protein+2&column=ki&startPg=0&Increment=50&submit=Search 163196286 476028218 1 MSSCRYNGGVMRPLSNLSSSRRNLHEMDSEAQPLQPPASVVGGGGGASSPSAAAAASSSAPEIVVSKPEHNNSNNLALYGTGGGGSTGGGGGGGGGGGGSGHGSSSGTKSSKKKNQNIGYKLGHRRALFEKRKRLSDYALIFGMFGIVVMVIETELSWGAYDKASLYSLALKCLISLSTIILLGLIIVYHAREIQLFMVDNGADDWRIAMTYERIFFICLEILVCAIHPIPGNYTFTWTARLAFSYAPSTTTADVDIILSIPMFLRLYLIARVMLLHSKLFTDASSRSIGALNKINFNTRFVMKTLMTICPGTVLLVFSISLWIIAAWTVRACERYHDQQDVTSNFLGAMWLISITFLSIGYGDMVPNTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRVKNAAANVLRETWLIYKNTKLVKKIDHAKVRKHQRKFLQAIHQLRSVKMEQRKLNDQANTLVDLAKTQNIMYDMISDLNERSEDFEKRIVTLETKLETLIGSIHALPGLISQTIRQQQRDFIETQMENYDKHVTYNAERSRSSSRRRRSSSTAPPTSSESS 1QX7 Small conductance calcium-activated potassium channel protein 2 KCNN2_RAT P70604 51443613 Cc1cc(C)n(n1)-c1nc(C)cc(Nc2cc(F)ccc2Cl)n1 InChI=1S/C16H15ClFN5/c1-9-7-15(20-14-8-12(18)4-5-13(14)17)21-16(19-9)23-11(3)6-10(2)22-23/h4-8H,1-3H3,(H,19,20,21) RJKGYBOMYOKJJV-UHFFFAOYSA-N 50583214 CHEMBL5076032 Small conductance calcium-activated potassium channel protein 2 2970 ChEMBL 10.1021/acs.jmedchem.1c01473 10.7270/Q28919R5 34962403 El-Sayed, NS; Nam, YW; Egorova, PA; Nguyen, HM; Orfali, R; Rahman, MA; Yang, G; Wulff, H; Bezprozvanny, I; Parang, K; Zhang, M Chapman University School of Pharmacy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50583214 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=342&target=Small+conductance+calcium-activated+potassium+channel+protein+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50583214&enzyme=Small+conductance+calcium-activated+potassium+channel+protein+2&column=ki&startPg=0&Increment=50&submit=Search 166625915 476028219 1 MSSCRYNGGVMRPLSNLSSSRRNLHEMDSEAQPLQPPASVVGGGGGASSPSAAAAASSSAPEIVVSKPEHNNSNNLALYGTGGGGSTGGGGGGGGGGGGSGHGSSSGTKSSKKKNQNIGYKLGHRRALFEKRKRLSDYALIFGMFGIVVMVIETELSWGAYDKASLYSLALKCLISLSTIILLGLIIVYHAREIQLFMVDNGADDWRIAMTYERIFFICLEILVCAIHPIPGNYTFTWTARLAFSYAPSTTTADVDIILSIPMFLRLYLIARVMLLHSKLFTDASSRSIGALNKINFNTRFVMKTLMTICPGTVLLVFSISLWIIAAWTVRACERYHDQQDVTSNFLGAMWLISITFLSIGYGDMVPNTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRVKNAAANVLRETWLIYKNTKLVKKIDHAKVRKHQRKFLQAIHQLRSVKMEQRKLNDQANTLVDLAKTQNIMYDMISDLNERSEDFEKRIVTLETKLETLIGSIHALPGLISQTIRQQQRDFIETQMENYDKHVTYNAERSRSSSRRRRSSSTAPPTSSESS 1QX7 Small conductance calcium-activated potassium channel protein 2 KCNN2_RAT P70604 51443614 Cc1cc(C)n(n1)-c1nc(C)cc(Nc2ccc(cc2)C(F)(F)F)n1 InChI=1S/C17H16F3N5/c1-10-9-15(22-14-6-4-13(5-7-14)17(18,19)20)23-16(21-10)25-12(3)8-11(2)24-25/h4-9H,1-3H3,(H,21,22,23) MUODWQJJYZZWMD-UHFFFAOYSA-N 50583215 CHEMBL5075016 Small conductance calcium-activated potassium channel protein 2 3450 ChEMBL 10.1021/acs.jmedchem.1c01473 10.7270/Q28919R5 34962403 El-Sayed, NS; Nam, YW; Egorova, PA; Nguyen, HM; Orfali, R; Rahman, MA; Yang, G; Wulff, H; Bezprozvanny, I; Parang, K; Zhang, M Chapman University School of Pharmacy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50583215 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=342&target=Small+conductance+calcium-activated+potassium+channel+protein+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50583215&enzyme=Small+conductance+calcium-activated+potassium+channel+protein+2&column=ki&startPg=0&Increment=50&submit=Search 166626284 476028220 1 MSSCRYNGGVMRPLSNLSSSRRNLHEMDSEAQPLQPPASVVGGGGGASSPSAAAAASSSAPEIVVSKPEHNNSNNLALYGTGGGGSTGGGGGGGGGGGGSGHGSSSGTKSSKKKNQNIGYKLGHRRALFEKRKRLSDYALIFGMFGIVVMVIETELSWGAYDKASLYSLALKCLISLSTIILLGLIIVYHAREIQLFMVDNGADDWRIAMTYERIFFICLEILVCAIHPIPGNYTFTWTARLAFSYAPSTTTADVDIILSIPMFLRLYLIARVMLLHSKLFTDASSRSIGALNKINFNTRFVMKTLMTICPGTVLLVFSISLWIIAAWTVRACERYHDQQDVTSNFLGAMWLISITFLSIGYGDMVPNTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRVKNAAANVLRETWLIYKNTKLVKKIDHAKVRKHQRKFLQAIHQLRSVKMEQRKLNDQANTLVDLAKTQNIMYDMISDLNERSEDFEKRIVTLETKLETLIGSIHALPGLISQTIRQQQRDFIETQMENYDKHVTYNAERSRSSSRRRRSSSTAPPTSSESS 1QX7 Small conductance calcium-activated potassium channel protein 2 KCNN2_RAT P70604 51443615 Cc1cc(C)n(n1)-c1nc(C)cc(Nc2ccc(c(Cl)c2)C(F)(F)F)n1 InChI=1S/C17H15ClF3N5/c1-9-7-15(24-16(22-9)26-11(3)6-10(2)25-26)23-12-4-5-13(14(18)8-12)17(19,20)21/h4-8H,1-3H3,(H,22,23,24) NCTVTJSVXURAKH-UHFFFAOYSA-N 50583216 CHEMBL5081906 Small conductance calcium-activated potassium channel protein 2 3270 ChEMBL 10.1021/acs.jmedchem.1c01473 10.7270/Q28919R5 34962403 El-Sayed, NS; Nam, YW; Egorova, PA; Nguyen, HM; Orfali, R; Rahman, MA; Yang, G; Wulff, H; Bezprozvanny, I; Parang, K; Zhang, M Chapman University School of Pharmacy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50583216 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=342&target=Small+conductance+calcium-activated+potassium+channel+protein+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50583216&enzyme=Small+conductance+calcium-activated+potassium+channel+protein+2&column=ki&startPg=0&Increment=50&submit=Search 166627890 476028221 1 MSSCRYNGGVMRPLSNLSSSRRNLHEMDSEAQPLQPPASVVGGGGGASSPSAAAAASSSAPEIVVSKPEHNNSNNLALYGTGGGGSTGGGGGGGGGGGGSGHGSSSGTKSSKKKNQNIGYKLGHRRALFEKRKRLSDYALIFGMFGIVVMVIETELSWGAYDKASLYSLALKCLISLSTIILLGLIIVYHAREIQLFMVDNGADDWRIAMTYERIFFICLEILVCAIHPIPGNYTFTWTARLAFSYAPSTTTADVDIILSIPMFLRLYLIARVMLLHSKLFTDASSRSIGALNKINFNTRFVMKTLMTICPGTVLLVFSISLWIIAAWTVRACERYHDQQDVTSNFLGAMWLISITFLSIGYGDMVPNTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRVKNAAANVLRETWLIYKNTKLVKKIDHAKVRKHQRKFLQAIHQLRSVKMEQRKLNDQANTLVDLAKTQNIMYDMISDLNERSEDFEKRIVTLETKLETLIGSIHALPGLISQTIRQQQRDFIETQMENYDKHVTYNAERSRSSSRRRRSSSTAPPTSSESS 1QX7 Small conductance calcium-activated potassium channel protein 2 KCNN2_RAT P70604 51443616 Cc1cc(C)n(n1)-c1nc(C)cc(Nc2cc(Cl)cc(c2)C(F)(F)F)n1 InChI=1S/C17H15ClF3N5/c1-9-5-15(24-16(22-9)26-11(3)4-10(2)25-26)23-14-7-12(17(19,20)21)6-13(18)8-14/h4-8H,1-3H3,(H,22,23,24) RPJNHTMYEQCRSU-UHFFFAOYSA-N 50583217 CHEMBL5084258 Small conductance calcium-activated potassium channel protein 2 >100000 ChEMBL 10.1021/acs.jmedchem.1c01473 10.7270/Q28919R5 34962403 El-Sayed, NS; Nam, YW; Egorova, PA; Nguyen, HM; Orfali, R; Rahman, MA; Yang, G; Wulff, H; Bezprozvanny, I; Parang, K; Zhang, M Chapman University School of Pharmacy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50583217 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=342&target=Small+conductance+calcium-activated+potassium+channel+protein+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50583217&enzyme=Small+conductance+calcium-activated+potassium+channel+protein+2&column=ki&startPg=0&Increment=50&submit=Search 166628173 476028222 1 MSSCRYNGGVMRPLSNLSSSRRNLHEMDSEAQPLQPPASVVGGGGGASSPSAAAAASSSAPEIVVSKPEHNNSNNLALYGTGGGGSTGGGGGGGGGGGGSGHGSSSGTKSSKKKNQNIGYKLGHRRALFEKRKRLSDYALIFGMFGIVVMVIETELSWGAYDKASLYSLALKCLISLSTIILLGLIIVYHAREIQLFMVDNGADDWRIAMTYERIFFICLEILVCAIHPIPGNYTFTWTARLAFSYAPSTTTADVDIILSIPMFLRLYLIARVMLLHSKLFTDASSRSIGALNKINFNTRFVMKTLMTICPGTVLLVFSISLWIIAAWTVRACERYHDQQDVTSNFLGAMWLISITFLSIGYGDMVPNTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRVKNAAANVLRETWLIYKNTKLVKKIDHAKVRKHQRKFLQAIHQLRSVKMEQRKLNDQANTLVDLAKTQNIMYDMISDLNERSEDFEKRIVTLETKLETLIGSIHALPGLISQTIRQQQRDFIETQMENYDKHVTYNAERSRSSSRRRRSSSTAPPTSSESS 1QX7 Small conductance calcium-activated potassium channel protein 2 KCNN2_RAT P70604 51443617 Cc1cc(C)n(n1)-c1nc(C)cc(Nc2cc(ccc2F)C(O)=O)n1 InChI=1S/C17H16FN5O2/c1-9-7-15(20-14-8-12(16(24)25)4-5-13(14)18)21-17(19-9)23-11(3)6-10(2)22-23/h4-8H,1-3H3,(H,24,25)(H,19,20,21) NGIDGTBXJDINCI-UHFFFAOYSA-N 50583218 CHEMBL5090801 Small conductance calcium-activated potassium channel protein 2 >30000 ChEMBL 10.1021/acs.jmedchem.1c01473 10.7270/Q28919R5 34962403 El-Sayed, NS; Nam, YW; Egorova, PA; Nguyen, HM; Orfali, R; Rahman, MA; Yang, G; Wulff, H; Bezprozvanny, I; Parang, K; Zhang, M Chapman University School of Pharmacy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50583218 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=342&target=Small+conductance+calcium-activated+potassium+channel+protein+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50583218&enzyme=Small+conductance+calcium-activated+potassium+channel+protein+2&column=ki&startPg=0&Increment=50&submit=Search 166636445 476028223 1 MSSCRYNGGVMRPLSNLSSSRRNLHEMDSEAQPLQPPASVVGGGGGASSPSAAAAASSSAPEIVVSKPEHNNSNNLALYGTGGGGSTGGGGGGGGGGGGSGHGSSSGTKSSKKKNQNIGYKLGHRRALFEKRKRLSDYALIFGMFGIVVMVIETELSWGAYDKASLYSLALKCLISLSTIILLGLIIVYHAREIQLFMVDNGADDWRIAMTYERIFFICLEILVCAIHPIPGNYTFTWTARLAFSYAPSTTTADVDIILSIPMFLRLYLIARVMLLHSKLFTDASSRSIGALNKINFNTRFVMKTLMTICPGTVLLVFSISLWIIAAWTVRACERYHDQQDVTSNFLGAMWLISITFLSIGYGDMVPNTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRVKNAAANVLRETWLIYKNTKLVKKIDHAKVRKHQRKFLQAIHQLRSVKMEQRKLNDQANTLVDLAKTQNIMYDMISDLNERSEDFEKRIVTLETKLETLIGSIHALPGLISQTIRQQQRDFIETQMENYDKHVTYNAERSRSSSRRRRSSSTAPPTSSESS 1QX7 Small conductance calcium-activated potassium channel protein 2 KCNN2_RAT P70604 51443618 Cc1cc(C)n(n1)-c1nc(N)cc(Nc2ccc(F)c(Cl)c2)n1 InChI=1S/C15H14ClFN6/c1-8-5-9(2)23(22-8)15-20-13(18)7-14(21-15)19-10-3-4-12(17)11(16)6-10/h3-7H,1-2H3,(H3,18,19,20,21) QJCKKQAOHOPXCM-UHFFFAOYSA-N 50583219 CHEMBL5088936 Small conductance calcium-activated potassium channel protein 2 6590 ChEMBL 10.1021/acs.jmedchem.1c01473 10.7270/Q28919R5 34962403 El-Sayed, NS; Nam, YW; Egorova, PA; Nguyen, HM; Orfali, R; Rahman, MA; Yang, G; Wulff, H; Bezprozvanny, I; Parang, K; Zhang, M Chapman University School of Pharmacy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50583219 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=342&target=Small+conductance+calcium-activated+potassium+channel+protein+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50583219&enzyme=Small+conductance+calcium-activated+potassium+channel+protein+2&column=ki&startPg=0&Increment=50&submit=Search 166634319 476028224 1 MSSCRYNGGVMRPLSNLSSSRRNLHEMDSEAQPLQPPASVVGGGGGASSPSAAAAASSSAPEIVVSKPEHNNSNNLALYGTGGGGSTGGGGGGGGGGGGSGHGSSSGTKSSKKKNQNIGYKLGHRRALFEKRKRLSDYALIFGMFGIVVMVIETELSWGAYDKASLYSLALKCLISLSTIILLGLIIVYHAREIQLFMVDNGADDWRIAMTYERIFFICLEILVCAIHPIPGNYTFTWTARLAFSYAPSTTTADVDIILSIPMFLRLYLIARVMLLHSKLFTDASSRSIGALNKINFNTRFVMKTLMTICPGTVLLVFSISLWIIAAWTVRACERYHDQQDVTSNFLGAMWLISITFLSIGYGDMVPNTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRVKNAAANVLRETWLIYKNTKLVKKIDHAKVRKHQRKFLQAIHQLRSVKMEQRKLNDQANTLVDLAKTQNIMYDMISDLNERSEDFEKRIVTLETKLETLIGSIHALPGLISQTIRQQQRDFIETQMENYDKHVTYNAERSRSSSRRRRSSSTAPPTSSESS 1QX7 Small conductance calcium-activated potassium channel protein 2 KCNN2_RAT P70604 51443619 Cc1cn(cn1)-c1nc(C)cc(Nc2cc(Cl)ccc2F)n1 InChI=1S/C15H13ClFN5/c1-9-5-14(20-13-6-11(16)3-4-12(13)17)21-15(19-9)22-7-10(2)18-8-22/h3-8H,1-2H3,(H,19,20,21) BBLPXMBZNANAIT-UHFFFAOYSA-N 50583220 CHEMBL5079766 Small conductance calcium-activated potassium channel protein 2 4510 ChEMBL 10.1021/acs.jmedchem.1c01473 10.7270/Q28919R5 34962403 El-Sayed, NS; Nam, YW; Egorova, PA; Nguyen, HM; Orfali, R; Rahman, MA; Yang, G; Wulff, H; Bezprozvanny, I; Parang, K; Zhang, M Chapman University School of Pharmacy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50583220 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=342&target=Small+conductance+calcium-activated+potassium+channel+protein+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50583220&enzyme=Small+conductance+calcium-activated+potassium+channel+protein+2&column=ki&startPg=0&Increment=50&submit=Search 166628765 476028225 1 MSSCRYNGGVMRPLSNLSSSRRNLHEMDSEAQPLQPPASVVGGGGGASSPSAAAAASSSAPEIVVSKPEHNNSNNLALYGTGGGGSTGGGGGGGGGGGGSGHGSSSGTKSSKKKNQNIGYKLGHRRALFEKRKRLSDYALIFGMFGIVVMVIETELSWGAYDKASLYSLALKCLISLSTIILLGLIIVYHAREIQLFMVDNGADDWRIAMTYERIFFICLEILVCAIHPIPGNYTFTWTARLAFSYAPSTTTADVDIILSIPMFLRLYLIARVMLLHSKLFTDASSRSIGALNKINFNTRFVMKTLMTICPGTVLLVFSISLWIIAAWTVRACERYHDQQDVTSNFLGAMWLISITFLSIGYGDMVPNTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRVKNAAANVLRETWLIYKNTKLVKKIDHAKVRKHQRKFLQAIHQLRSVKMEQRKLNDQANTLVDLAKTQNIMYDMISDLNERSEDFEKRIVTLETKLETLIGSIHALPGLISQTIRQQQRDFIETQMENYDKHVTYNAERSRSSSRRRRSSSTAPPTSSESS 1QX7 Small conductance calcium-activated potassium channel protein 2 KCNN2_RAT P70604 51443620 Cc1cn(cn1)-c1nc(C)cc(Nc2ccc(F)c(Cl)c2)n1 InChI=1S/C15H13ClFN5/c1-9-5-14(20-11-3-4-13(17)12(16)6-11)21-15(19-9)22-7-10(2)18-8-22/h3-8H,1-2H3,(H,19,20,21) OWEQIMYKBVXMIW-UHFFFAOYSA-N 50583221 CHEMBL5088498 Small conductance calcium-activated potassium channel protein 2 38810 ChEMBL 10.1021/acs.jmedchem.1c01473 10.7270/Q28919R5 34962403 El-Sayed, NS; Nam, YW; Egorova, PA; Nguyen, HM; Orfali, R; Rahman, MA; Yang, G; Wulff, H; Bezprozvanny, I; Parang, K; Zhang, M Chapman University School of Pharmacy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50583221 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=342&target=Small+conductance+calcium-activated+potassium+channel+protein+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50583221&enzyme=Small+conductance+calcium-activated+potassium+channel+protein+2&column=ki&startPg=0&Increment=50&submit=Search 166635346 476028226 1 MSSCRYNGGVMRPLSNLSSSRRNLHEMDSEAQPLQPPASVVGGGGGASSPSAAAAASSSAPEIVVSKPEHNNSNNLALYGTGGGGSTGGGGGGGGGGGGSGHGSSSGTKSSKKKNQNIGYKLGHRRALFEKRKRLSDYALIFGMFGIVVMVIETELSWGAYDKASLYSLALKCLISLSTIILLGLIIVYHAREIQLFMVDNGADDWRIAMTYERIFFICLEILVCAIHPIPGNYTFTWTARLAFSYAPSTTTADVDIILSIPMFLRLYLIARVMLLHSKLFTDASSRSIGALNKINFNTRFVMKTLMTICPGTVLLVFSISLWIIAAWTVRACERYHDQQDVTSNFLGAMWLISITFLSIGYGDMVPNTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRVKNAAANVLRETWLIYKNTKLVKKIDHAKVRKHQRKFLQAIHQLRSVKMEQRKLNDQANTLVDLAKTQNIMYDMISDLNERSEDFEKRIVTLETKLETLIGSIHALPGLISQTIRQQQRDFIETQMENYDKHVTYNAERSRSSSRRRRSSSTAPPTSSESS 1QX7 Small conductance calcium-activated potassium channel protein 2 KCNN2_RAT P70604 51443621 Cc1nc(co1)-c1nc(C)cc(Nc2cc(Cl)ccc2F)n1 InChI=1S/C15H12ClFN4O/c1-8-5-14(20-12-6-10(16)3-4-11(12)17)21-15(18-8)13-7-22-9(2)19-13/h3-7H,1-2H3,(H,18,20,21) NJGZWTMMPFTMCP-UHFFFAOYSA-N 50583222 CHEMBL5094693 Small conductance calcium-activated potassium channel protein 2 13770 ChEMBL 10.1021/acs.jmedchem.1c01473 10.7270/Q28919R5 34962403 El-Sayed, NS; Nam, YW; Egorova, PA; Nguyen, HM; Orfali, R; Rahman, MA; Yang, G; Wulff, H; Bezprozvanny, I; Parang, K; Zhang, M Chapman University School of Pharmacy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50583222 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=342&target=Small+conductance+calcium-activated+potassium+channel+protein+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50583222&enzyme=Small+conductance+calcium-activated+potassium+channel+protein+2&column=ki&startPg=0&Increment=50&submit=Search 166634472 476028227 1 MSSCRYNGGVMRPLSNLSSSRRNLHEMDSEAQPLQPPASVVGGGGGASSPSAAAAASSSAPEIVVSKPEHNNSNNLALYGTGGGGSTGGGGGGGGGGGGSGHGSSSGTKSSKKKNQNIGYKLGHRRALFEKRKRLSDYALIFGMFGIVVMVIETELSWGAYDKASLYSLALKCLISLSTIILLGLIIVYHAREIQLFMVDNGADDWRIAMTYERIFFICLEILVCAIHPIPGNYTFTWTARLAFSYAPSTTTADVDIILSIPMFLRLYLIARVMLLHSKLFTDASSRSIGALNKINFNTRFVMKTLMTICPGTVLLVFSISLWIIAAWTVRACERYHDQQDVTSNFLGAMWLISITFLSIGYGDMVPNTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRVKNAAANVLRETWLIYKNTKLVKKIDHAKVRKHQRKFLQAIHQLRSVKMEQRKLNDQANTLVDLAKTQNIMYDMISDLNERSEDFEKRIVTLETKLETLIGSIHALPGLISQTIRQQQRDFIETQMENYDKHVTYNAERSRSSSRRRRSSSTAPPTSSESS 1QX7 Small conductance calcium-activated potassium channel protein 2 KCNN2_RAT P70604 51443622 Cc1nc(co1)-c1nc(C)cc(Nc2ccc(F)c(Cl)c2)n1 InChI=1S/C15H12ClFN4O/c1-8-5-14(20-10-3-4-12(17)11(16)6-10)21-15(18-8)13-7-22-9(2)19-13/h3-7H,1-2H3,(H,18,20,21) BBUVGFVTXASMBB-UHFFFAOYSA-N 50583223 CHEMBL5077913 Small conductance calcium-activated potassium channel protein 2 3590 ChEMBL 10.1021/acs.jmedchem.1c01473 10.7270/Q28919R5 34962403 El-Sayed, NS; Nam, YW; Egorova, PA; Nguyen, HM; Orfali, R; Rahman, MA; Yang, G; Wulff, H; Bezprozvanny, I; Parang, K; Zhang, M Chapman University School of Pharmacy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50583223 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=342&target=Small+conductance+calcium-activated+potassium+channel+protein+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50583223&enzyme=Small+conductance+calcium-activated+potassium+channel+protein+2&column=ki&startPg=0&Increment=50&submit=Search 166629165 476028228 1 MSSCRYNGGVMRPLSNLSSSRRNLHEMDSEAQPLQPPASVVGGGGGASSPSAAAAASSSAPEIVVSKPEHNNSNNLALYGTGGGGSTGGGGGGGGGGGGSGHGSSSGTKSSKKKNQNIGYKLGHRRALFEKRKRLSDYALIFGMFGIVVMVIETELSWGAYDKASLYSLALKCLISLSTIILLGLIIVYHAREIQLFMVDNGADDWRIAMTYERIFFICLEILVCAIHPIPGNYTFTWTARLAFSYAPSTTTADVDIILSIPMFLRLYLIARVMLLHSKLFTDASSRSIGALNKINFNTRFVMKTLMTICPGTVLLVFSISLWIIAAWTVRACERYHDQQDVTSNFLGAMWLISITFLSIGYGDMVPNTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRVKNAAANVLRETWLIYKNTKLVKKIDHAKVRKHQRKFLQAIHQLRSVKMEQRKLNDQANTLVDLAKTQNIMYDMISDLNERSEDFEKRIVTLETKLETLIGSIHALPGLISQTIRQQQRDFIETQMENYDKHVTYNAERSRSSSRRRRSSSTAPPTSSESS 1QX7 Small conductance calcium-activated potassium channel protein 2 KCNN2_RAT P70604 51443623 Cc1cc(C)n(n1)-c1cc(Nc2cccc(Cl)c2)nc(N)n1 InChI=1S/C15H15ClN6/c1-9-6-10(2)22(21-9)14-8-13(19-15(17)20-14)18-12-5-3-4-11(16)7-12/h3-8H,1-2H3,(H3,17,18,19,20) WKORTUOTAZLKMS-UHFFFAOYSA-N 50583224 CHEMBL5090420 Small conductance calcium-activated potassium channel protein 2 >100000 ChEMBL 10.1021/acs.jmedchem.1c01473 10.7270/Q28919R5 34962403 El-Sayed, NS; Nam, YW; Egorova, PA; Nguyen, HM; Orfali, R; Rahman, MA; Yang, G; Wulff, H; Bezprozvanny, I; Parang, K; Zhang, M Chapman University School of Pharmacy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50583224 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=342&target=Small+conductance+calcium-activated+potassium+channel+protein+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50583224&enzyme=Small+conductance+calcium-activated+potassium+channel+protein+2&column=ki&startPg=0&Increment=50&submit=Search 166635038 476028229 1 MSSCRYNGGVMRPLSNLSSSRRNLHEMDSEAQPLQPPASVVGGGGGASSPSAAAAASSSAPEIVVSKPEHNNSNNLALYGTGGGGSTGGGGGGGGGGGGSGHGSSSGTKSSKKKNQNIGYKLGHRRALFEKRKRLSDYALIFGMFGIVVMVIETELSWGAYDKASLYSLALKCLISLSTIILLGLIIVYHAREIQLFMVDNGADDWRIAMTYERIFFICLEILVCAIHPIPGNYTFTWTARLAFSYAPSTTTADVDIILSIPMFLRLYLIARVMLLHSKLFTDASSRSIGALNKINFNTRFVMKTLMTICPGTVLLVFSISLWIIAAWTVRACERYHDQQDVTSNFLGAMWLISITFLSIGYGDMVPNTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRVKNAAANVLRETWLIYKNTKLVKKIDHAKVRKHQRKFLQAIHQLRSVKMEQRKLNDQANTLVDLAKTQNIMYDMISDLNERSEDFEKRIVTLETKLETLIGSIHALPGLISQTIRQQQRDFIETQMENYDKHVTYNAERSRSSSRRRRSSSTAPPTSSESS 1QX7 Small conductance calcium-activated potassium channel protein 2 KCNN2_RAT P70604 51443624 Cc1cc(C)n(n1)-c1cc(Nc2ccc(F)c(Cl)c2)nc(N)n1 InChI=1S/C15H14ClFN6/c1-8-5-9(2)23(22-8)14-7-13(20-15(18)21-14)19-10-3-4-12(17)11(16)6-10/h3-7H,1-2H3,(H3,18,19,20,21) ADEJDCHMTWJEJA-UHFFFAOYSA-N 50583225 CHEMBL5076140 Small conductance calcium-activated potassium channel protein 2 >100000 ChEMBL 10.1021/acs.jmedchem.1c01473 10.7270/Q28919R5 34962403 El-Sayed, NS; Nam, YW; Egorova, PA; Nguyen, HM; Orfali, R; Rahman, MA; Yang, G; Wulff, H; Bezprozvanny, I; Parang, K; Zhang, M Chapman University School of Pharmacy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50583225 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=342&target=Small+conductance+calcium-activated+potassium+channel+protein+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50583225&enzyme=Small+conductance+calcium-activated+potassium+channel+protein+2&column=ki&startPg=0&Increment=50&submit=Search 166627249 476028230 1 MSSCRYNGGVMRPLSNLSSSRRNLHEMDSEAQPLQPPASVVGGGGGASSPSAAAAASSSAPEIVVSKPEHNNSNNLALYGTGGGGSTGGGGGGGGGGGGSGHGSSSGTKSSKKKNQNIGYKLGHRRALFEKRKRLSDYALIFGMFGIVVMVIETELSWGAYDKASLYSLALKCLISLSTIILLGLIIVYHAREIQLFMVDNGADDWRIAMTYERIFFICLEILVCAIHPIPGNYTFTWTARLAFSYAPSTTTADVDIILSIPMFLRLYLIARVMLLHSKLFTDASSRSIGALNKINFNTRFVMKTLMTICPGTVLLVFSISLWIIAAWTVRACERYHDQQDVTSNFLGAMWLISITFLSIGYGDMVPNTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRVKNAAANVLRETWLIYKNTKLVKKIDHAKVRKHQRKFLQAIHQLRSVKMEQRKLNDQANTLVDLAKTQNIMYDMISDLNERSEDFEKRIVTLETKLETLIGSIHALPGLISQTIRQQQRDFIETQMENYDKHVTYNAERSRSSSRRRRSSSTAPPTSSESS 1QX7 Small conductance calcium-activated potassium channel protein 2 KCNN2_RAT P70604 51443625 Cc1cc(C)n(n1)-c1cc(Nc2cc(Cl)ccc2F)nc(N)n1 InChI=1S/C15H14ClFN6/c1-8-5-9(2)23(22-8)14-7-13(20-15(18)21-14)19-12-6-10(16)3-4-11(12)17/h3-7H,1-2H3,(H3,18,19,20,21) MGAIUPUQFXOZGL-UHFFFAOYSA-N 50583226 CHEMBL5086120 Small conductance calcium-activated potassium channel protein 2 >100000 ChEMBL 10.1021/acs.jmedchem.1c01473 10.7270/Q28919R5 34962403 El-Sayed, NS; Nam, YW; Egorova, PA; Nguyen, HM; Orfali, R; Rahman, MA; Yang, G; Wulff, H; Bezprozvanny, I; Parang, K; Zhang, M Chapman University School of Pharmacy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50583226 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=342&target=Small+conductance+calcium-activated+potassium+channel+protein+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50583226&enzyme=Small+conductance+calcium-activated+potassium+channel+protein+2&column=ki&startPg=0&Increment=50&submit=Search 166635923 476028231 1 MSSCRYNGGVMRPLSNLSSSRRNLHEMDSEAQPLQPPASVVGGGGGASSPSAAAAASSSAPEIVVSKPEHNNSNNLALYGTGGGGSTGGGGGGGGGGGGSGHGSSSGTKSSKKKNQNIGYKLGHRRALFEKRKRLSDYALIFGMFGIVVMVIETELSWGAYDKASLYSLALKCLISLSTIILLGLIIVYHAREIQLFMVDNGADDWRIAMTYERIFFICLEILVCAIHPIPGNYTFTWTARLAFSYAPSTTTADVDIILSIPMFLRLYLIARVMLLHSKLFTDASSRSIGALNKINFNTRFVMKTLMTICPGTVLLVFSISLWIIAAWTVRACERYHDQQDVTSNFLGAMWLISITFLSIGYGDMVPNTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRVKNAAANVLRETWLIYKNTKLVKKIDHAKVRKHQRKFLQAIHQLRSVKMEQRKLNDQANTLVDLAKTQNIMYDMISDLNERSEDFEKRIVTLETKLETLIGSIHALPGLISQTIRQQQRDFIETQMENYDKHVTYNAERSRSSSRRRRSSSTAPPTSSESS 1QX7 Small conductance calcium-activated potassium channel protein 2 KCNN2_RAT P70604 51443626 Cc1cc(C)n(n1)-c1cc(Nc2ccc(Cl)cc2F)nc(N)n1 InChI=1S/C15H14ClFN6/c1-8-5-9(2)23(22-8)14-7-13(20-15(18)21-14)19-12-4-3-10(16)6-11(12)17/h3-7H,1-2H3,(H3,18,19,20,21) KABRRMZUUJSLGH-UHFFFAOYSA-N 50583227 CHEMBL5079837 Small conductance calcium-activated potassium channel protein 2 >100000 ChEMBL 10.1021/acs.jmedchem.1c01473 10.7270/Q28919R5 34962403 El-Sayed, NS; Nam, YW; Egorova, PA; Nguyen, HM; Orfali, R; Rahman, MA; Yang, G; Wulff, H; Bezprozvanny, I; Parang, K; Zhang, M Chapman University School of Pharmacy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50583227 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=342&target=Small+conductance+calcium-activated+potassium+channel+protein+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50583227&enzyme=Small+conductance+calcium-activated+potassium+channel+protein+2&column=ki&startPg=0&Increment=50&submit=Search 166627391 476028232 1 MSSCRYNGGVMRPLSNLSSSRRNLHEMDSEAQPLQPPASVVGGGGGASSPSAAAAASSSAPEIVVSKPEHNNSNNLALYGTGGGGSTGGGGGGGGGGGGSGHGSSSGTKSSKKKNQNIGYKLGHRRALFEKRKRLSDYALIFGMFGIVVMVIETELSWGAYDKASLYSLALKCLISLSTIILLGLIIVYHAREIQLFMVDNGADDWRIAMTYERIFFICLEILVCAIHPIPGNYTFTWTARLAFSYAPSTTTADVDIILSIPMFLRLYLIARVMLLHSKLFTDASSRSIGALNKINFNTRFVMKTLMTICPGTVLLVFSISLWIIAAWTVRACERYHDQQDVTSNFLGAMWLISITFLSIGYGDMVPNTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRVKNAAANVLRETWLIYKNTKLVKKIDHAKVRKHQRKFLQAIHQLRSVKMEQRKLNDQANTLVDLAKTQNIMYDMISDLNERSEDFEKRIVTLETKLETLIGSIHALPGLISQTIRQQQRDFIETQMENYDKHVTYNAERSRSSSRRRRSSSTAPPTSSESS 1QX7 Small conductance calcium-activated potassium channel protein 2 KCNN2_RAT P70604 51443627 Cc1cc(C)n(n1)-c1cc(Nc2cc(F)ccc2Cl)nc(N)n1 InChI=1S/C15H14ClFN6/c1-8-5-9(2)23(22-8)14-7-13(20-15(18)21-14)19-12-6-10(17)3-4-11(12)16/h3-7H,1-2H3,(H3,18,19,20,21) BQGUTCLIUQHONQ-UHFFFAOYSA-N 50583228 CHEMBL5072517 Small conductance calcium-activated potassium channel protein 2 >100000 ChEMBL 10.1021/acs.jmedchem.1c01473 10.7270/Q28919R5 34962403 El-Sayed, NS; Nam, YW; Egorova, PA; Nguyen, HM; Orfali, R; Rahman, MA; Yang, G; Wulff, H; Bezprozvanny, I; Parang, K; Zhang, M Chapman University School of Pharmacy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50583228 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=342&target=Small+conductance+calcium-activated+potassium+channel+protein+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50583228&enzyme=Small+conductance+calcium-activated+potassium+channel+protein+2&column=ki&startPg=0&Increment=50&submit=Search 166630677 476028233 1 MSSCRYNGGVMRPLSNLSSSRRNLHEMDSEAQPLQPPASVVGGGGGASSPSAAAAASSSAPEIVVSKPEHNNSNNLALYGTGGGGSTGGGGGGGGGGGGSGHGSSSGTKSSKKKNQNIGYKLGHRRALFEKRKRLSDYALIFGMFGIVVMVIETELSWGAYDKASLYSLALKCLISLSTIILLGLIIVYHAREIQLFMVDNGADDWRIAMTYERIFFICLEILVCAIHPIPGNYTFTWTARLAFSYAPSTTTADVDIILSIPMFLRLYLIARVMLLHSKLFTDASSRSIGALNKINFNTRFVMKTLMTICPGTVLLVFSISLWIIAAWTVRACERYHDQQDVTSNFLGAMWLISITFLSIGYGDMVPNTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRVKNAAANVLRETWLIYKNTKLVKKIDHAKVRKHQRKFLQAIHQLRSVKMEQRKLNDQANTLVDLAKTQNIMYDMISDLNERSEDFEKRIVTLETKLETLIGSIHALPGLISQTIRQQQRDFIETQMENYDKHVTYNAERSRSSSRRRRSSSTAPPTSSESS 1QX7 Small conductance calcium-activated potassium channel protein 2 KCNN2_RAT P70604 51443628 Cc1cc(C)n(n1)-c1cc(Nc2cc(F)ccc2F)nc(N)n1 InChI=1S/C15H14F2N6/c1-8-5-9(2)23(22-8)14-7-13(20-15(18)21-14)19-12-6-10(16)3-4-11(12)17/h3-7H,1-2H3,(H3,18,19,20,21) NMKXNKVERDTZQD-UHFFFAOYSA-N 50583229 CHEMBL5088379 Small conductance calcium-activated potassium channel protein 2 >100000 ChEMBL 10.1021/acs.jmedchem.1c01473 10.7270/Q28919R5 34962403 El-Sayed, NS; Nam, YW; Egorova, PA; Nguyen, HM; Orfali, R; Rahman, MA; Yang, G; Wulff, H; Bezprozvanny, I; Parang, K; Zhang, M Chapman University School of Pharmacy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50583229 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=342&target=Small+conductance+calcium-activated+potassium+channel+protein+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50583229&enzyme=Small+conductance+calcium-activated+potassium+channel+protein+2&column=ki&startPg=0&Increment=50&submit=Search 166632648 476028234 1 MSSCRYNGGVMRPLSNLSSSRRNLHEMDSEAQPLQPPASVVGGGGGASSPSAAAAASSSAPEIVVSKPEHNNSNNLALYGTGGGGSTGGGGGGGGGGGGSGHGSSSGTKSSKKKNQNIGYKLGHRRALFEKRKRLSDYALIFGMFGIVVMVIETELSWGAYDKASLYSLALKCLISLSTIILLGLIIVYHAREIQLFMVDNGADDWRIAMTYERIFFICLEILVCAIHPIPGNYTFTWTARLAFSYAPSTTTADVDIILSIPMFLRLYLIARVMLLHSKLFTDASSRSIGALNKINFNTRFVMKTLMTICPGTVLLVFSISLWIIAAWTVRACERYHDQQDVTSNFLGAMWLISITFLSIGYGDMVPNTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRVKNAAANVLRETWLIYKNTKLVKKIDHAKVRKHQRKFLQAIHQLRSVKMEQRKLNDQANTLVDLAKTQNIMYDMISDLNERSEDFEKRIVTLETKLETLIGSIHALPGLISQTIRQQQRDFIETQMENYDKHVTYNAERSRSSSRRRRSSSTAPPTSSESS 1QX7 Small conductance calcium-activated potassium channel protein 2 KCNN2_RAT P70604 51443629 Cc1cc(C)n(n1)-c1cc(Nc2ccc(c(Cl)c2)C(F)(F)F)nc(N)n1 InChI=1S/C16H14ClF3N6/c1-8-5-9(2)26(25-8)14-7-13(23-15(21)24-14)22-10-3-4-11(12(17)6-10)16(18,19)20/h3-7H,1-2H3,(H3,21,22,23,24) LABIHYKHHMSVJU-UHFFFAOYSA-N 50583230 CHEMBL5075803 Small conductance calcium-activated potassium channel protein 2 >100000 ChEMBL 10.1021/acs.jmedchem.1c01473 10.7270/Q28919R5 34962403 El-Sayed, NS; Nam, YW; Egorova, PA; Nguyen, HM; Orfali, R; Rahman, MA; Yang, G; Wulff, H; Bezprozvanny, I; Parang, K; Zhang, M Chapman University School of Pharmacy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50583230 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=342&target=Small+conductance+calcium-activated+potassium+channel+protein+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50583230&enzyme=Small+conductance+calcium-activated+potassium+channel+protein+2&column=ki&startPg=0&Increment=50&submit=Search 166627085 476028235 1 MSSCRYNGGVMRPLSNLSSSRRNLHEMDSEAQPLQPPASVVGGGGGASSPSAAAAASSSAPEIVVSKPEHNNSNNLALYGTGGGGSTGGGGGGGGGGGGSGHGSSSGTKSSKKKNQNIGYKLGHRRALFEKRKRLSDYALIFGMFGIVVMVIETELSWGAYDKASLYSLALKCLISLSTIILLGLIIVYHAREIQLFMVDNGADDWRIAMTYERIFFICLEILVCAIHPIPGNYTFTWTARLAFSYAPSTTTADVDIILSIPMFLRLYLIARVMLLHSKLFTDASSRSIGALNKINFNTRFVMKTLMTICPGTVLLVFSISLWIIAAWTVRACERYHDQQDVTSNFLGAMWLISITFLSIGYGDMVPNTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRVKNAAANVLRETWLIYKNTKLVKKIDHAKVRKHQRKFLQAIHQLRSVKMEQRKLNDQANTLVDLAKTQNIMYDMISDLNERSEDFEKRIVTLETKLETLIGSIHALPGLISQTIRQQQRDFIETQMENYDKHVTYNAERSRSSSRRRRSSSTAPPTSSESS 1QX7 Small conductance calcium-activated potassium channel protein 2 KCNN2_RAT P70604