BindingDB Reactant_set_id Ligand SMILES Ligand InChI Ligand InChI Key BindingDB MonomerID BindingDB Ligand Name Target Name Target Source Organism According to Curator or DataSource Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) kon (M-1-s-1) koff (s-1) pH Temp (C) Curation/DataSource Article DOI BindingDB Entry DOI PMID PubChem AID Patent Number Authors Institution Link to Ligand in BindingDB Link to Target in BindingDB Link to Ligand-Target Pair in BindingDB Ligand HET ID in PDB PDB ID(s) for Ligand-Target Complex PubChem CID of Ligand PubChem SID of Ligand ChEBI ID of Ligand ChEMBL ID of Ligand DrugBank ID of Ligand IUPHAR_GRAC ID of Ligand KEGG ID of Ligand ZINC ID of Ligand Number of Protein Chains in Target (>1 implies a multichain complex) BindingDB Target Chain Sequence PDB ID(s) of Target Chain UniProt (SwissProt) Recommended Name of Target Chain UniProt (SwissProt) Entry Name of Target Chain UniProt (SwissProt) Primary ID of Target Chain UniProt (SwissProt) Secondary ID(s) of Target Chain UniProt (SwissProt) Alternative ID(s) of Target Chain UniProt (TrEMBL) Submitted Name of Target Chain UniProt (TrEMBL) Entry Name of Target Chain UniProt (TrEMBL) Primary ID of Target Chain UniProt (TrEMBL) Secondary ID(s) of Target Chain UniProt (TrEMBL) Alternative ID(s) of Target Chain 51058615 CCc1cccc2C(C(=O)Nc12)=C1SC(=S)NC1=O InChI=1S/C13H10N2O2S2/c1-2-6-4-3-5-7-8(11(16)14-9(6)7)10-12(17)15-13(18)19-10/h3-5H,2H2,1H3,(H,14,16)(H,15,17,18) WSOJBINOLIOJTD-UHFFFAOYSA-N 50431809 CHEMBL2347062 Ribosomal protein S6 kinase alpha-3 Homo sapiens 17000 ChEMBL 10.1016/j.bmc.2013.01.047 10.7270/Q2GQ704N 23434140 Zhong, Y; Xue, M; Zhao, X; Yuan, J; Liu, X; Huang, J; Zhao, Z; Li, H; Xu, Y East China University of Science and Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50431809 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50431809&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 5342663 164160684 CHEMBL2347062 ZINC15018381 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 51058616 Cc1cccc2C(C(=O)Nc12)=C1SC(=S)NC1=O InChI=1S/C12H8N2O2S2/c1-5-3-2-4-6-7(10(15)13-8(5)6)9-11(16)14-12(17)18-9/h2-4H,1H3,(H,13,15)(H,14,16,17) YKPCAIZGCTXESO-UHFFFAOYSA-N 50431810 CHEMBL2347061 Ribosomal protein S6 kinase alpha-3 Homo sapiens 1680 ChEMBL 10.1016/j.bmc.2013.01.047 10.7270/Q2GQ704N 23434140 Zhong, Y; Xue, M; Zhao, X; Yuan, J; Liu, X; Huang, J; Zhao, Z; Li, H; Xu, Y East China University of Science and Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50431810 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50431810&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 5454819 164160685 CHEMBL2347061 ZINC15018442 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 51058617 Fc1ccc2NC(=O)C(=Cc3c[nH]nc3-c3ccccc3)c2c1 InChI=1S/C18H12FN3O/c19-13-6-7-16-14(9-13)15(18(23)21-16)8-12-10-20-22-17(12)11-4-2-1-3-5-11/h1-10H,(H,20,22)(H,21,23) DINXQJVLLOMREI-UHFFFAOYSA-N 50431811 CHEMBL2347054 Ribosomal protein S6 kinase alpha-3 Homo sapiens 8590 ChEMBL 10.1016/j.bmc.2013.01.047 10.7270/Q2GQ704N 23434140 Zhong, Y; Xue, M; Zhao, X; Yuan, J; Liu, X; Huang, J; Zhao, Z; Li, H; Xu, Y East China University of Science and Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50431811 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50431811&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 71511480 164160686 CHEMBL2347054 ZINC95603141 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 51058618 [O-][N+](=O)c1ccccc1-c1n[nH]cc1C=C1C(=O)Nc2ccccc12 InChI=1S/C18H12N4O3/c23-18-14(12-5-1-3-7-15(12)20-18)9-11-10-19-21-17(11)13-6-2-4-8-16(13)22(24)25/h1-10H,(H,19,21)(H,20,23) XLYVQVWMTOLDNL-UHFFFAOYSA-N 50431812 CHEMBL2347053 Ribosomal protein S6 kinase alpha-3 Homo sapiens 500 ChEMBL 10.1016/j.bmc.2013.01.047 10.7270/Q2GQ704N 23434140 Zhong, Y; Xue, M; Zhao, X; Yuan, J; Liu, X; Huang, J; Zhao, Z; Li, H; Xu, Y East China University of Science and Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50431812 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50431812&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 5703619 164160687 CHEMBL2347053 ZINC12369272 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 51058619 O=C1Nc2ccccc2C1=Cc1c[nH]nc1-c1ccccc1 InChI=1S/C18H13N3O/c22-18-15(14-8-4-5-9-16(14)20-18)10-13-11-19-21-17(13)12-6-2-1-3-7-12/h1-11H,(H,19,21)(H,20,22) RINGOEHWKXCHGN-UHFFFAOYSA-N 50344214 3-((3-phenyl-1H-pyrazol-4-yl)methylene)indolin-2-one::CHEMBL1778710 Ribosomal protein S6 kinase alpha-3 Homo sapiens 2720 ChEMBL 10.1016/j.bmc.2013.01.047 10.7270/Q2GQ704N 23434140 Zhong, Y; Xue, M; Zhao, X; Yuan, J; Liu, X; Huang, J; Zhao, Z; Li, H; Xu, Y East China University of Science and Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50344214 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50344214&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 5714584 131347150 CHEMBL1778710 ZINC13465359 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 51058620 Nc1ccc2NC(=O)\C(=C\c3ccco3)c2c1 InChI=1S/C13H10N2O2/c14-8-3-4-12-10(6-8)11(13(16)15-12)7-9-2-1-5-17-9/h1-7H,14H2,(H,15,16)/b11-7+ VSEGODXJTWWVIT-YRNVUSSQSA-N 50431813 CHEMBL2347085 Ribosomal protein S6 kinase alpha-3 Homo sapiens 2490 ChEMBL 10.1016/j.bmc.2013.01.047 10.7270/Q2GQ704N 23434140 Zhong, Y; Xue, M; Zhao, X; Yuan, J; Liu, X; Huang, J; Zhao, Z; Li, H; Xu, Y East China University of Science and Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50431813 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50431813&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 71680549 164160688 CHEMBL2347085 ZINC95603144 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 51058621 Brc1ccc2NC(=O)\C(=C\c3ccco3)c2c1 InChI=1S/C13H8BrNO2/c14-8-3-4-12-10(6-8)11(13(16)15-12)7-9-2-1-5-17-9/h1-7H,(H,15,16)/b11-7+ CBYUHHGMVIHGFQ-YRNVUSSQSA-N 50431814 CHEMBL2347075 Ribosomal protein S6 kinase alpha-3 Homo sapiens 1510 ChEMBL 10.1016/j.bmc.2013.01.047 10.7270/Q2GQ704N 23434140 Zhong, Y; Xue, M; Zhao, X; Yuan, J; Liu, X; Huang, J; Zhao, Z; Li, H; Xu, Y East China University of Science and Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50431814 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50431814&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 6164317 164160689 CHEMBL2347075 ZINC00213444 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 51058622 Clc1ccc2NC(=O)\C(=C\c3ccco3)c2c1 InChI=1S/C13H8ClNO2/c14-8-3-4-12-10(6-8)11(13(16)15-12)7-9-2-1-5-17-9/h1-7H,(H,15,16)/b11-7+ LQIWKQNFITUIPZ-YRNVUSSQSA-N 50431815 CHEMBL2347074 Ribosomal protein S6 kinase alpha-3 Homo sapiens 2020 ChEMBL 10.1016/j.bmc.2013.01.047 10.7270/Q2GQ704N 23434140 Zhong, Y; Xue, M; Zhao, X; Yuan, J; Liu, X; Huang, J; Zhao, Z; Li, H; Xu, Y East China University of Science and Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50431815 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50431815&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 6164860 164160690 CHEMBL2347074 ZINC00213513 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 51058623 O=C1Nc2ccccc2\C1=C\c1ccco1 InChI=1S/C13H9NO2/c15-13-11(8-9-4-3-7-16-9)10-5-1-2-6-12(10)14-13/h1-8H,(H,14,15)/b11-8- PGZGBDVILWVGSF-FLIBITNWSA-N 50431816 CHEMBL2347073 Ribosomal protein S6 kinase alpha-3 Homo sapiens 3470 ChEMBL 10.1016/j.bmc.2013.01.047 10.7270/Q2GQ704N 23434140 Zhong, Y; Xue, M; Zhao, X; Yuan, J; Liu, X; Huang, J; Zhao, Z; Li, H; Xu, Y East China University of Science and Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50431816 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50431816&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 5476622 164160691 CHEMBL2347073 ZINC00136914 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 51058625 Cc1ccc(cc1)-c1c(C(=O)CF)n(CCCO)c2ncnc(N)c12 InChI=1S/C18H19FN4O2/c1-11-3-5-12(6-4-11)14-15-17(20)21-10-22-18(15)23(7-2-8-24)16(14)13(25)9-19/h3-6,10,24H,2,7-9H2,1H3,(H2,20,21,22) IKLGYJACVCXYIL-UHFFFAOYSA-N 50248765 1-(4-amino-7-(3-hydroxypropyl)-5-p-tolyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl)-2-fluoroethanone::CHEMBL515414 Ribosomal protein S6 kinase alpha-3 Homo sapiens 15 ChEMBL 10.1016/j.bmc.2013.01.047 10.7270/Q2GQ704N 23434140 Zhong, Y; Xue, M; Zhao, X; Yuan, J; Liu, X; Huang, J; Zhao, Z; Li, H; Xu, Y East China University of Science and Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50248765 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50248765&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 644243 104103317 CHEMBL515414 ZINC06718642 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 51058626 C[C@@H]1O[C@@H](Oc2c(O)c3c(cc(O)cc3=O)oc2-c2ccc(O)cc2)[C@H](O)[C@H](OC(C)=O)[C@H]1OC(C)=O InChI=1S/C25H24O12/c1-10-21(34-11(2)26)24(35-12(3)27)20(32)25(33-10)37-23-19(31)18-16(30)8-15(29)9-17(18)36-22(23)13-4-6-14(28)7-5-13/h4-10,20-21,24-25,28-29,31-32H,1-3H3/t10-,20+,21-,24-,25-/m0/s1 POZDUGKSCAGWQI-IGKKHSBFSA-N 50241294 CHEMBL240954::SL-0101::kaempferol 3-O-(3'',4''-di-O-acetyl-alpha-L-rhamnopyranoside::kaempferol-3-O-(3,4-di-O-acetyl-alpha-L-rhamnopyranoside) Ribosomal protein S6 kinase alpha-3 Homo sapiens 89 ChEMBL 10.1016/j.bmc.2013.01.047 10.7270/Q2GQ704N 23434140 Zhong, Y; Xue, M; Zhao, X; Yuan, J; Liu, X; Huang, J; Zhao, Z; Li, H; Xu, Y East China University of Science and Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50241294 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50241294&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 10459196 104098696 CHEMBL240954 ZINC28875874 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 45282 CC(C)CCN1C(C)C(=O)N(C)c2cnc(Nc3cc(F)c(O)c(F)c3)nc12 InChI=1S/C19H23F2N5O2/c1-10(2)5-6-26-11(3)18(28)25(4)15-9-22-19(24-17(15)26)23-12-7-13(20)16(27)14(21)8-12/h7-11,27H,5-6H2,1-4H3,(H,22,23,24) DTEKTGDVSARYDS-UHFFFAOYSA-N 25017 2-[(3,5-difluoro-4-hydroxyphenyl)amino]-5,7-dimethyl-8-(3-methylbutyl)-5,6,7,8-tetrahydropteridin-6-one::BI-D1870 Ribosomal protein S6 kinase alpha-3 Homo sapiens 24 7.5 22.00 C Curated from the literature by BindingDB 10.1042/BJ20061088 10.7270/Q25Q4TD7 17040210 aid1798500 Sapkota, GP; Cummings, L; Newell, FS; Armstrong, C; Bain, J; Frodin, M; Grauert, M; Hoffmann, M; Schnapp, G; Steegmaier, M; Cohen, P; Alessi, DR University of Dundee http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25017 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25017&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 584 5WIK,5D9K,7N7L 25023738 56374161 ZINC33359423 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 66899 CN1CCN(CC1)c1ccc2nc([nH]c2c1)-c1c(N)c2c(F)cccc2[nH]c1=O InChI=1S/C21H21FN6O/c1-27-7-9-28(10-8-27)12-5-6-14-16(11-12)25-20(24-14)18-19(23)17-13(22)3-2-4-15(17)26-21(18)29/h2-6,11H,7-10H2,1H3,(H,24,25)(H3,23,26,29) PIQCTGMSNWUMAF-UHFFFAOYSA-N 25118 (3Z)-4-amino-5-fluoro-3-[5-(4-methylpiperazino)-1,3-dihydrobenzimidazol-2-ylidene]carbostyril::4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-1,3-benzodiazol-2-yl]-1,2-dihydroquinolin-2-one::CHEMBL522892::CHIR-258 Ribosomal protein S6 kinase alpha-3 Homo sapiens 5600000 PubChem 10.7270/Q21N7ZHF aid1433 PubChem, PC Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25118 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25118&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 9886808 56374260 CHEMBL522892 5962 ZINC03816310 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 66900 CN(C)C[C@@H]1CCn2cc(C3=C(C(=O)NC3=O)c3cn(CCO1)c1ccccc31)c1ccccc21 InChI=1S/C28H28N4O3/c1-30(2)15-18-11-12-31-16-21(19-7-3-5-9-23(19)31)25-26(28(34)29-27(25)33)22-17-32(13-14-35-18)24-10-6-4-8-20(22)24/h3-10,16-18H,11-15H2,1-2H3,(H,29,33,34)/t18-/m0/s1 ZCBUQCWBWNUWSU-SFHVURJKSA-N 17055 (18S)-18-[(dimethylamino)methyl]-17-oxa-4,14,21-triazahexacyclo[19.6.1.1^{7,14}.0^{2,6}.0^{8,13}.0^{22,27}]nonacosa-1(28),2(6),7(29),8(13),9,11,22(27),23,25-nonaene-3,5-dione::(9S)-9-[(dimethylamino)methyl]-6,7,10,11-tetrahydro-9H,18H-5,21:12,17-di(metheno)dibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecine-18,20(19H)-dione::K00587a::LY 333531::LY-333531::LY333531::Ruboxistaurin::cid_153999 Ribosomal protein S6 kinase alpha-3 Homo sapiens 3600000 PubChem 10.7270/Q21N7ZHF aid1433 PubChem, PC Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17055 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17055&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search LY4 2J2I,1UU3 153999 46517285 5263 ZINC03812168 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 66901 CO[C@H]1[C@H](C[C@@H]2O[C@@]1(C)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13)N(C)C(=O)c1ccccc1 InChI=1S/C35H30N4O4/c1-35-32(42-3)25(37(2)34(41)19-11-5-4-6-12-19)17-26(43-35)38-23-15-9-7-13-20(23)28-29-22(18-36-33(29)40)27-21-14-8-10-16-24(21)39(35)31(27)30(28)38/h4-16,25-26,32H,17-18H2,1-3H3,(H,36,40)/t25-,26-,32-,35+/m0/s1 BMGQWWVMWDBQGC-PZFYLCKJSA-N 31094 PKC-412::cid_24202429 Ribosomal protein S6 kinase alpha-3 Homo sapiens 740000 PubChem 10.7270/Q21N7ZHF aid1433 PubChem, PC Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31094 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31094&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 24202429 242052840 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 66902 Cc1[nH]c(\C=C2/C(=O)Nc3ccc(F)cc23)c(C)c1C(=O)NC[C@H](O)CN1CCOCC1 InChI=1S/C23H27FN4O4/c1-13-20(10-18-17-9-15(24)3-4-19(17)27-22(18)30)26-14(2)21(13)23(31)25-11-16(29)12-28-5-7-32-8-6-28/h3-4,9-10,16,26,29H,5-8,11-12H2,1-2H3,(H,25,31)(H,27,30)/b18-10-/t16-/m0/s1 CTNPALGJUAXMMC-PMFHANACSA-N 31095 5-[(Z)-(5-fluoranyl-2-oxidanylidene-1H-indol-3-ylidene)methyl]-2,4-dimethyl-N-[(2S)-3-morpholin-4-yl-2-oxidanyl-propyl]-1H-pyrrole-3-carboxamide::5-[(Z)-(5-fluoro-2-keto-indolin-3-ylidene)methyl]-N-[(2S)-2-hydroxy-3-morpholino-propyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide::5-[(Z)-(5-fluoro-2-oxo-1H-indol-3-ylidene)methyl]-N-[(2S)-2-hydroxy-3-(4-morpholinyl)propyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide::5-[(Z)-(5-fluoro-2-oxo-1H-indol-3-ylidene)methyl]-N-[(2S)-2-hydroxy-3-morpholin-4-ylpropyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide::SU-14813::cid_10138259 Ribosomal protein S6 kinase alpha-3 Homo sapiens 2100000 PubChem 10.7270/Q21N7ZHF aid1433 PubChem, PC Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31095 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31095&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 10138259 252615339 ZINC18825344 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 66903 CN[C@H]1C[C@@H]2O[C@](C)([C@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m0/s1 HKSZLNNOFSGOKW-HMWZOHBLSA-N 31096 CHEMBL290084::Staurosporine::cid_451705 Ribosomal protein S6 kinase alpha-3 Homo sapiens 69000 PubChem 10.7270/Q21N7ZHF aid1433 PubChem, PC Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31096 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31096&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 451705 242052841 CHEMBL290084 346 ZINC05615681 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 66904 CCN(CC)CCNC(=O)c1c(C)[nH]c(\C=C2/C(=O)Nc3ccc(F)cc23)c1C InChI=1S/C22H27FN4O2/c1-5-27(6-2)10-9-24-22(29)20-13(3)19(25-14(20)4)12-17-16-11-15(23)7-8-18(16)26-21(17)28/h7-8,11-12,25H,5-6,9-10H2,1-4H3,(H,24,29)(H,26,28)/b17-12- WINHZLLDWRZWRT-ATVHPVEESA-N 4814 CHEMBL535::N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide::N-[2-(diethylamino)ethyl]-5-{[(3Z)-5-fluoro-2-oxo-2,3-dihydro-1H-indol-3-ylidene]methyl}-2,4-dimethyl-1H-pyrrole-3-carboxamide::SU11248::SUNITINIB::SUNITINIB MALATE::US10464902, Sunitinib::US9163010, Sunitinib::US9914707, SU11248 Ribosomal protein S6 kinase alpha-3 Homo sapiens 580000 PubChem 10.7270/Q21N7ZHF aid1433 PubChem, PC Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=4814 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=4814&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search B49 6NG0,4KS8,3G0F,3G0E,2Y7J,6JOK,6M11,3MIY,3TI1,4QMZ,6V0X,6NFZ,6NFY,4AGD 5329102 8034462 38940 CHEMBL535 DB01268 5713 ZINC03964325 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 66905 CN1CCN(CC1)c1cc(Nc2cc(C)n[nH]2)nc(Sc2ccc(NC(=O)C3CC3)cc2)n1 InChI=1S/C23H28N8OS/c1-15-13-20(29-28-15)25-19-14-21(31-11-9-30(2)10-12-31)27-23(26-19)33-18-7-5-17(6-8-18)24-22(32)16-3-4-16/h5-8,13-14,16H,3-4,9-12H2,1-2H3,(H,24,32)(H2,25,26,27,28,29) GCIKSSRWRFVXBI-UHFFFAOYSA-N 13534 CHEMBL572878::N-[4-({4-[(3-methyl-1H-pyrazol-5-yl)amino]-6-(4-methylpiperazin-1-yl)pyrimidin-2-yl}sulfanyl)phenyl]cyclopropanecarboxamide::N-[4-[[4-(4-methylpiperazino)-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl]thio]phenyl]cyclopropanecarboxamide::VX-680::VX680::cyclopropane carboxylic acid {4-[4-(4-methyl-piperazin-1-yl)-6-(5-methyl-2H-pyrazol-3-ylamino)-pyrimidin-2ylsulphanyl]-phenyl}-amide Ribosomal protein S6 kinase alpha-3 Homo sapiens 6400000 PubChem 10.7270/Q21N7ZHF aid1433 PubChem, PC Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13534 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13534&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search VX6 2F4J,6GR9,6BRJ,3E5A,4ZOG,4B8M,5WNM,3AMB,4JBQ,4AF3,2XYN 5494449 46513935 CHEMBL572878 5718 ZINC03820040 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 202128 CC1CN(CC(C)O1)c1nc2ccccn2c(=O)c1N InChI=1S/C14H18N4O2/c1-9-7-17(8-10(2)20-9)13-12(15)14(19)18-6-4-3-5-11(18)16-13/h3-6,9-10H,7-8,15H2,1-2H3 GWZYDSKWIQPDBX-UHFFFAOYSA-N 93224 Kinase inhibitor, A1 Ribosomal protein S6 kinase alpha-3 Homo sapiens 1.96e+5 Curated from the literature by BindingDB 10.1021/cb300729y 10.7270/Q2MG7N3W 23534475 aid1799900 Urich, R; Wishart, G; Kiczun, M; Richters, A; Tidten-Luksch, N; Rauh, D; Sherborne, B; Wyatt, PG; Brenk, R University of Dundee http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=93224 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=93224&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 71463562 163340359 ZINC96142672 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 311875 O=C(Nc1cccnc1)c1ccc2nc3C(=O)NCCCn3c2c1 InChI=1S/C17H15N5O2/c23-16(20-12-3-1-6-18-10-12)11-4-5-13-14(9-11)22-8-2-7-19-17(24)15(22)21-13/h1,3-6,9-10H,2,7-8H2,(H,19,24)(H,20,23) NTXOERDSELUUJC-UHFFFAOYSA-N 167967 US9073926, 1 Ribosomal protein S6 kinase alpha-3 Homo sapiens 5600 7.5 US Patent 10.7270/Q2BP01J6 aid1801413 US9073926 Boyer, SJ; Burke, J; Guo, X; Kirrane, Jr., TM; Snow, RJ; Zhang, Y Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167967 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167967&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 67237942 312525381 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 311876 Cn1c(NC(=O)c2ccc3nc4C(=O)NCCCn4c3c2)nc2ccccc12 InChI=1S/C20H18N6O2/c1-25-15-6-3-2-5-13(15)23-20(25)24-18(27)12-7-8-14-16(11-12)26-10-4-9-21-19(28)17(26)22-14/h2-3,5-8,11H,4,9-10H2,1H3,(H,21,28)(H,23,24,27) XUAKNRZAHPCZNV-UHFFFAOYSA-N 167968 US9073926, 2 Ribosomal protein S6 kinase alpha-3 Homo sapiens 35 7.5 US Patent 10.7270/Q2BP01J6 aid1801413 US9073926 Boyer, SJ; Burke, J; Guo, X; Kirrane, Jr., TM; Snow, RJ; Zhang, Y Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167968 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167968&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 68322692 312525382 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 311877 CCn1c(NC(=O)c2ccc3nc4C(=O)NCCCn4c3c2)nc2ccccc12 InChI=1S/C21H20N6O2/c1-2-26-16-7-4-3-6-14(16)24-21(26)25-19(28)13-8-9-15-17(12-13)27-11-5-10-22-20(29)18(27)23-15/h3-4,6-9,12H,2,5,10-11H2,1H3,(H,22,29)(H,24,25,28) HIWDEEKFVOBEDG-UHFFFAOYSA-N 167969 US9073926, 3 Ribosomal protein S6 kinase alpha-3 Homo sapiens 5.5 7.5 US Patent 10.7270/Q2BP01J6 aid1801413 US9073926 Boyer, SJ; Burke, J; Guo, X; Kirrane, Jr., TM; Snow, RJ; Zhang, Y Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167969 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167969&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 67240109 312525383 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 311878 CC(C)n1c(NC(=O)c2ccc3nc4C(=O)NCCCn4c3c2)nc2ccccc12 InChI=1S/C22H22N6O2/c1-13(2)28-17-7-4-3-6-15(17)25-22(28)26-20(29)14-8-9-16-18(12-14)27-11-5-10-23-21(30)19(27)24-16/h3-4,6-9,12-13H,5,10-11H2,1-2H3,(H,23,30)(H,25,26,29) TWUMJNHHODMHNL-UHFFFAOYSA-N 167970 US9073926, 4 Ribosomal protein S6 kinase alpha-3 Homo sapiens 33 7.5 US Patent 10.7270/Q2BP01J6 aid1801413 US9073926 Boyer, SJ; Burke, J; Guo, X; Kirrane, Jr., TM; Snow, RJ; Zhang, Y Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167970 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167970&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 53242174 312525384 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 311879 Cc1ccnc(NC(=O)c2ccc3nc4C(=O)NCCCn4c3c2)c1 InChI=1S/C18H17N5O2/c1-11-5-7-19-15(9-11)22-17(24)12-3-4-13-14(10-12)23-8-2-6-20-18(25)16(23)21-13/h3-5,7,9-10H,2,6,8H2,1H3,(H,20,25)(H,19,22,24) SMUQHDGUBPGZGE-UHFFFAOYSA-N 167971 US9073926, 5 Ribosomal protein S6 kinase alpha-3 Homo sapiens 3200 7.5 US Patent 10.7270/Q2BP01J6 aid1801413 US9073926 Boyer, SJ; Burke, J; Guo, X; Kirrane, Jr., TM; Snow, RJ; Zhang, Y Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167971 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167971&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 68322665 312525385 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 311880 O=C(Nc1cnn(Cc2ccccc2)c1)c1ccc2nc3C(=O)NCCCn3c2c1 InChI=1S/C22H20N6O2/c29-21(25-17-12-24-27(14-17)13-15-5-2-1-3-6-15)16-7-8-18-19(11-16)28-10-4-9-23-22(30)20(28)26-18/h1-3,5-8,11-12,14H,4,9-10,13H2,(H,23,30)(H,25,29) NOLQEYVCYRCPPK-UHFFFAOYSA-N 167972 US9073926, 6 Ribosomal protein S6 kinase alpha-3 Homo sapiens 44 7.5 US Patent 10.7270/Q2BP01J6 aid1801413 US9073926 Boyer, SJ; Burke, J; Guo, X; Kirrane, Jr., TM; Snow, RJ; Zhang, Y Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167972 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167972&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 68322663 312525386 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 311881 Cc1nc(cs1)-c1cccc(NC(=O)c2ccc3nc4C(=O)NCCCn4c3c2)c1 InChI=1S/C22H19N5O2S/c1-13-24-18(12-30-13)14-4-2-5-16(10-14)25-21(28)15-6-7-17-19(11-15)27-9-3-8-23-22(29)20(27)26-17/h2,4-7,10-12H,3,8-9H2,1H3,(H,23,29)(H,25,28) GEAJTWHHUPQLRH-UHFFFAOYSA-N 167973 US9073926, 7 Ribosomal protein S6 kinase alpha-3 Homo sapiens 1700 7.5 US Patent 10.7270/Q2BP01J6 aid1801413 US9073926 Boyer, SJ; Burke, J; Guo, X; Kirrane, Jr., TM; Snow, RJ; Zhang, Y Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167973 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167973&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 68322664 312525387 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 311882 Fc1cccc(NC(=O)c2ccc3nc4C(=O)NCCCn4c3c2)c1 InChI=1S/C18H15FN4O2/c19-12-3-1-4-13(10-12)21-17(24)11-5-6-14-15(9-11)23-8-2-7-20-18(25)16(23)22-14/h1,3-6,9-10H,2,7-8H2,(H,20,25)(H,21,24) VIXLRYPHJBBDMB-UHFFFAOYSA-N 167974 US9073926, 8 Ribosomal protein S6 kinase alpha-3 Homo sapiens 960 7.5 US Patent 10.7270/Q2BP01J6 aid1801413 US9073926 Boyer, SJ; Burke, J; Guo, X; Kirrane, Jr., TM; Snow, RJ; Zhang, Y Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167974 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167974&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 68322666 312525388 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 311883 NC(=O)c1ccccc1NC(=O)c1ccc2nc3C(=O)NCCCn3c2c1 InChI=1S/C19H17N5O3/c20-16(25)12-4-1-2-5-13(12)23-18(26)11-6-7-14-15(10-11)24-9-3-8-21-19(27)17(24)22-14/h1-2,4-7,10H,3,8-9H2,(H2,20,25)(H,21,27)(H,23,26) VFOVHOQMPWWNPV-UHFFFAOYSA-N 167975 US9073926, 9 Ribosomal protein S6 kinase alpha-3 Homo sapiens 295 7.5 US Patent 10.7270/Q2BP01J6 aid1801413 US9073926 Boyer, SJ; Burke, J; Guo, X; Kirrane, Jr., TM; Snow, RJ; Zhang, Y Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167975 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167975&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 89585619 312525389 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 311884 Cn1cc(NC(=O)c2ccc3nc4C(=O)NCCCn4c3c2)nc1C(=O)NC1CCCC1 InChI=1S/C22H25N7O3/c1-28-12-17(26-18(28)22(32)24-14-5-2-3-6-14)27-20(30)13-7-8-15-16(11-13)29-10-4-9-23-21(31)19(29)25-15/h7-8,11-12,14H,2-6,9-10H2,1H3,(H,23,31)(H,24,32)(H,27,30) UNRWZBUXURMJLA-UHFFFAOYSA-N 167976 US9073926, 10 Ribosomal protein S6 kinase alpha-3 Homo sapiens 69 7.5 US Patent 10.7270/Q2BP01J6 aid1801413 US9073926 Boyer, SJ; Burke, J; Guo, X; Kirrane, Jr., TM; Snow, RJ; Zhang, Y Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167976 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167976&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 89585670 312525390 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 311885 CC(C)n1ncc2cc(NC(=O)c3ccc4nc5C(=O)NCCCn5c4c3)cnc12 InChI=1S/C21H21N7O2/c1-12(2)28-18-14(10-24-28)8-15(11-23-18)25-20(29)13-4-5-16-17(9-13)27-7-3-6-22-21(30)19(27)26-16/h4-5,8-12H,3,6-7H2,1-2H3,(H,22,30)(H,25,29) DBQAJQQGPQIDLD-UHFFFAOYSA-N 167977 US9073926, 11 Ribosomal protein S6 kinase alpha-3 Homo sapiens 870 7.5 US Patent 10.7270/Q2BP01J6 aid1801413 US9073926 Boyer, SJ; Burke, J; Guo, X; Kirrane, Jr., TM; Snow, RJ; Zhang, Y Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167977 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167977&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 89585594 312525391 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 311886 O=C(Nc1cnc2ccccc2c1)c1ccc2nc3C(=O)NCCCn3c2c1 InChI=1S/C21H17N5O2/c27-20(24-15-10-13-4-1-2-5-16(13)23-12-15)14-6-7-17-18(11-14)26-9-3-8-22-21(28)19(26)25-17/h1-2,4-7,10-12H,3,8-9H2,(H,22,28)(H,24,27) IUBOVMXHGBTLME-UHFFFAOYSA-N 167978 US9073926, 12 Ribosomal protein S6 kinase alpha-3 Homo sapiens 1200 7.5 US Patent 10.7270/Q2BP01J6 aid1801413 US9073926 Boyer, SJ; Burke, J; Guo, X; Kirrane, Jr., TM; Snow, RJ; Zhang, Y Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167978 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167978&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 68322595 312525392 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 311887 Cn1cc(NC(=O)c2ccc3nc4C(=O)NCCCn4c3c2)cn1 InChI=1S/C16H16N6O2/c1-21-9-11(8-18-21)19-15(23)10-3-4-12-13(7-10)22-6-2-5-17-16(24)14(22)20-12/h3-4,7-9H,2,5-6H2,1H3,(H,17,24)(H,19,23) BNGKFHKLNDIATR-UHFFFAOYSA-N 167979 US9073926, 13 Ribosomal protein S6 kinase alpha-3 Homo sapiens 320 7.5 US Patent 10.7270/Q2BP01J6 aid1801413 US9073926 Boyer, SJ; Burke, J; Guo, X; Kirrane, Jr., TM; Snow, RJ; Zhang, Y Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167979 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167979&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 89585582 312525393 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 311888 Cn1cc(NC(=O)c2ccc3nc4C(=O)NCCC(C)(C)n4c3c2)cn1 InChI=1S/C18H20N6O2/c1-18(2)6-7-19-17(26)15-22-13-5-4-11(8-14(13)24(15)18)16(25)21-12-9-20-23(3)10-12/h4-5,8-10H,6-7H2,1-3H3,(H,19,26)(H,21,25) KIVVSMMKIIIXEN-UHFFFAOYSA-N 167980 US9073926, 14 Ribosomal protein S6 kinase alpha-3 Homo sapiens 4000 7.5 US Patent 10.7270/Q2BP01J6 aid1801413 US9073926 Boyer, SJ; Burke, J; Guo, X; Kirrane, Jr., TM; Snow, RJ; Zhang, Y Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167980 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167980&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 89585620 312525394 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 311889 CCn1c(NC(=O)c2ccc3nc4C(=O)NCCCn4c3c2)nc2ccc(Cl)nc12 InChI=1S/C20H18ClN7O2/c1-2-27-16-13(6-7-15(21)25-16)24-20(27)26-18(29)11-4-5-12-14(10-11)28-9-3-8-22-19(30)17(28)23-12/h4-7,10H,2-3,8-9H2,1H3,(H,22,30)(H,24,26,29) HGWRPHQJLMJBQA-UHFFFAOYSA-N 167981 US9073926, 15 Ribosomal protein S6 kinase alpha-3 Homo sapiens 45 7.5 US Patent 10.7270/Q2BP01J6 aid1801413 US9073926 Boyer, SJ; Burke, J; Guo, X; Kirrane, Jr., TM; Snow, RJ; Zhang, Y Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167981 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167981&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 89585652 312525395 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 311890 CN(C)CCCn1c(NC(=O)c2ccc3nc4C(=O)NCCCn4c3c2)nc2ccccc12 InChI=1S/C24H27N7O2/c1-29(2)12-6-14-31-19-8-4-3-7-17(19)27-24(31)28-22(32)16-9-10-18-20(15-16)30-13-5-11-25-23(33)21(30)26-18/h3-4,7-10,15H,5-6,11-14H2,1-2H3,(H,25,33)(H,27,28,32) HXTSCEKORFMGBI-UHFFFAOYSA-N 167982 US9073926, 16 Ribosomal protein S6 kinase alpha-3 Homo sapiens 92 7.5 US Patent 10.7270/Q2BP01J6 aid1801413 US9073926 Boyer, SJ; Burke, J; Guo, X; Kirrane, Jr., TM; Snow, RJ; Zhang, Y Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167982 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167982&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 89585642 312525396 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 311891 CCn1c(NC(=O)c2ccc3nc4C(=O)NCCCn4c3c2)nc2cccnc12 InChI=1S/C20H19N7O2/c1-2-26-16-14(5-3-8-21-16)24-20(26)25-18(28)12-6-7-13-15(11-12)27-10-4-9-22-19(29)17(27)23-13/h3,5-8,11H,2,4,9-10H2,1H3,(H,22,29)(H,24,25,28) IBUYZUJUVMHXAU-UHFFFAOYSA-N 167983 US9073926, 17 Ribosomal protein S6 kinase alpha-3 Homo sapiens 23 7.5 US Patent 10.7270/Q2BP01J6 aid1801413 US9073926 Boyer, SJ; Burke, J; Guo, X; Kirrane, Jr., TM; Snow, RJ; Zhang, Y Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167983 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167983&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 89585630 312525397 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 311892 CC(C)n1c(NC(=O)c2ccc3nc4C(=O)NCCC(C)(C)n4c3c2)nc2ccccc12 InChI=1S/C24H26N6O2/c1-14(2)29-18-8-6-5-7-16(18)27-23(29)28-21(31)15-9-10-17-19(13-15)30-20(26-17)22(32)25-12-11-24(30,3)4/h5-10,13-14H,11-12H2,1-4H3,(H,25,32)(H,27,28,31) XPXROBNEPUYDHT-UHFFFAOYSA-N 167984 US9073926, 18 Ribosomal protein S6 kinase alpha-3 Homo sapiens 4.7 7.5 US Patent 10.7270/Q2BP01J6 aid1801413 US9073926 Boyer, SJ; Burke, J; Guo, X; Kirrane, Jr., TM; Snow, RJ; Zhang, Y Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167984 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167984&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 53242175 312525398 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 311893 O=C(Nc1cc(no1)-c1ccccc1)c1ccc2nc3C(=O)NCCCn3c2c1 InChI=1S/C21H17N5O3/c27-20(24-18-12-16(25-29-18)13-5-2-1-3-6-13)14-7-8-15-17(11-14)26-10-4-9-22-21(28)19(26)23-15/h1-3,5-8,11-12H,4,9-10H2,(H,22,28)(H,24,27) SMGYOERWRLLOJT-UHFFFAOYSA-N 167985 US9073926, 19 Ribosomal protein S6 kinase alpha-3 Homo sapiens 290 7.5 US Patent 10.7270/Q2BP01J6 aid1801413 US9073926 Boyer, SJ; Burke, J; Guo, X; Kirrane, Jr., TM; Snow, RJ; Zhang, Y Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167985 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167985&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 68322670 312525399 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 311894 Cc1cc(NC(=O)c2ccc3nc4C(=O)NCCCn4c3c2)no1 InChI=1S/C16H15N5O3/c1-9-7-13(20-24-9)19-15(22)10-3-4-11-12(8-10)21-6-2-5-17-16(23)14(21)18-11/h3-4,7-8H,2,5-6H2,1H3,(H,17,23)(H,19,20,22) ANDKZPJYPPFDOM-UHFFFAOYSA-N 167986 US9073926, 20 Ribosomal protein S6 kinase alpha-3 Homo sapiens 1550 7.5 US Patent 10.7270/Q2BP01J6 aid1801413 US9073926 Boyer, SJ; Burke, J; Guo, X; Kirrane, Jr., TM; Snow, RJ; Zhang, Y Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167986 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167986&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 68322629 312525400 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 311895 CC(C)(C)c1cc(NC(=O)c2ccc3nc4C(=O)NCCCn4c3c2)no1 InChI=1S/C19H21N5O3/c1-19(2,3)14-10-15(23-27-14)22-17(25)11-5-6-12-13(9-11)24-8-4-7-20-18(26)16(24)21-12/h5-6,9-10H,4,7-8H2,1-3H3,(H,20,26)(H,22,23,25) MIBQXOPDHBSXEI-UHFFFAOYSA-N 167987 US9073926, 21 Ribosomal protein S6 kinase alpha-3 Homo sapiens 2000 7.5 US Patent 10.7270/Q2BP01J6 aid1801413 US9073926 Boyer, SJ; Burke, J; Guo, X; Kirrane, Jr., TM; Snow, RJ; Zhang, Y Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167987 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167987&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 89585683 312525401 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 311896 O=C(Nc1cccc(c1)-c1c[nH]cn1)c1ccc2nc3C(=O)NCCCn3c2c1 InChI=1S/C21H18N6O2/c28-20(25-15-4-1-3-13(9-15)17-11-22-12-24-17)14-5-6-16-18(10-14)27-8-2-7-23-21(29)19(27)26-16/h1,3-6,9-12H,2,7-8H2,(H,22,24)(H,23,29)(H,25,28) SUWROSUZAZIMBS-UHFFFAOYSA-N 167988 US9073926, 22 Ribosomal protein S6 kinase alpha-3 Homo sapiens 1700 7.5 US Patent 10.7270/Q2BP01J6 aid1801413 US9073926 Boyer, SJ; Burke, J; Guo, X; Kirrane, Jr., TM; Snow, RJ; Zhang, Y Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167988 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167988&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 67237023 312525402 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 311897 O=C(Nc1cnc2ccccc2c1)c1ccc2cc3C(=O)NCCCn3c2n1 InChI=1S/C21H17N5O2/c27-20(24-15-10-13-4-1-2-5-16(13)23-12-15)17-7-6-14-11-18-21(28)22-8-3-9-26(18)19(14)25-17/h1-2,4-7,10-12H,3,8-9H2,(H,22,28)(H,24,27) CTPVTASKZQBESS-UHFFFAOYSA-N 167989 US9073926, 23 Ribosomal protein S6 kinase alpha-3 Homo sapiens 9.2 7.5 US Patent 10.7270/Q2BP01J6 aid1801413 US9073926 Boyer, SJ; Burke, J; Guo, X; Kirrane, Jr., TM; Snow, RJ; Zhang, Y Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167989 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167989&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 53242199 312525403 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 311898 Cc1nc(cs1)-c1cccc(NC(=O)c2ccc3cc4C(=O)NCCCn4c3n2)c1 InChI=1S/C22H19N5O2S/c1-13-24-18(12-30-13)14-4-2-5-16(10-14)25-21(28)17-7-6-15-11-19-22(29)23-8-3-9-27(19)20(15)26-17/h2,4-7,10-12H,3,8-9H2,1H3,(H,23,29)(H,25,28) JSGGVCXEKFWRSW-UHFFFAOYSA-N 167990 US9073926, 24 Ribosomal protein S6 kinase alpha-3 Homo sapiens 56 7.5 US Patent 10.7270/Q2BP01J6 aid1801413 US9073926 Boyer, SJ; Burke, J; Guo, X; Kirrane, Jr., TM; Snow, RJ; Zhang, Y Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167990 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167990&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 89592385 312525404 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 311899 Fc1cccc(NC(=O)c2ccc3cc4C(=O)NCCCn4c3n2)c1 InChI=1S/C18H15FN4O2/c19-12-3-1-4-13(10-12)21-17(24)14-6-5-11-9-15-18(25)20-7-2-8-23(15)16(11)22-14/h1,3-6,9-10H,2,7-8H2,(H,20,25)(H,21,24) JGGFTDCGSPWVHI-UHFFFAOYSA-N 167991 US9073926, 25 Ribosomal protein S6 kinase alpha-3 Homo sapiens 20 7.5 US Patent 10.7270/Q2BP01J6 aid1801413 US9073926 Boyer, SJ; Burke, J; Guo, X; Kirrane, Jr., TM; Snow, RJ; Zhang, Y Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167991 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167991&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 53242179 312525405 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 311900 NC(=O)c1ccccc1NC(=O)c1ccc2cc3C(=O)NCCCn3c2n1 InChI=1S/C19H17N5O3/c20-16(25)12-4-1-2-5-13(12)23-18(26)14-7-6-11-10-15-19(27)21-8-3-9-24(15)17(11)22-14/h1-2,4-7,10H,3,8-9H2,(H2,20,25)(H,21,27)(H,23,26) GXOLWQVEFZJSDG-UHFFFAOYSA-N 167992 US9073926, 26 Ribosomal protein S6 kinase alpha-3 Homo sapiens 2.3 7.5 US Patent 10.7270/Q2BP01J6 aid1801413 US9073926 Boyer, SJ; Burke, J; Guo, X; Kirrane, Jr., TM; Snow, RJ; Zhang, Y Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167992 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167992&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 53242223 312525406 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 311901 O=C(Nc1cccnc1)c1ccc2cc3C(=O)NCCCn3c2n1 InChI=1S/C17H15N5O2/c23-16(20-12-3-1-6-18-10-12)13-5-4-11-9-14-17(24)19-7-2-8-22(14)15(11)21-13/h1,3-6,9-10H,2,7-8H2,(H,19,24)(H,20,23) ZBPWYWRJCWAYEQ-UHFFFAOYSA-N 167993 US9073926, 27 Ribosomal protein S6 kinase alpha-3 Homo sapiens 37 7.5 US Patent 10.7270/Q2BP01J6 aid1801413 US9073926 Boyer, SJ; Burke, J; Guo, X; Kirrane, Jr., TM; Snow, RJ; Zhang, Y Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167993 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167993&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 68322791 312525407 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 311902 CCOC(=O)c1nc(NC(=O)c2ccc3cc4C(=O)NCCCn4c3n2)cn1C InChI=1S/C19H20N6O4/c1-3-29-19(28)16-22-14(10-24(16)2)23-17(26)12-6-5-11-9-13-18(27)20-7-4-8-25(13)15(11)21-12/h5-6,9-10H,3-4,7-8H2,1-2H3,(H,20,27)(H,23,26) HFKVSRQGYCGTCO-UHFFFAOYSA-N 167994 US9073926, 28 Ribosomal protein S6 kinase alpha-3 Homo sapiens 90 7.5 US Patent 10.7270/Q2BP01J6 aid1801413 US9073926 Boyer, SJ; Burke, J; Guo, X; Kirrane, Jr., TM; Snow, RJ; Zhang, Y Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167994 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167994&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 67237114 312525408 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 311903 CC(C)n1ncc2cc(NC(=O)c3ccc4cc5C(=O)NCCC(C)n5c4n3)cnc12 InChI=1S/C22H23N7O2/c1-12(2)29-19-15(10-25-29)8-16(11-24-19)26-21(30)17-5-4-14-9-18-22(31)23-7-6-13(3)28(18)20(14)27-17/h4-5,8-13H,6-7H2,1-3H3,(H,23,31)(H,26,30) YBDVSJKTAWTRHQ-UHFFFAOYSA-N 167995 US9073926, 29 Ribosomal protein S6 kinase alpha-3 Homo sapiens 2.1 7.5 US Patent 10.7270/Q2BP01J6 aid1801413 US9073926 Boyer, SJ; Burke, J; Guo, X; Kirrane, Jr., TM; Snow, RJ; Zhang, Y Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167995 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167995&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 53242182 312525409 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 311904 CC(C)n1ncc2cc(NC(=O)c3ccc4cc5C(=O)NCCCn5c4n3)cnc12 InChI=1S/C21H21N7O2/c1-12(2)28-18-14(10-24-28)8-15(11-23-18)25-20(29)16-5-4-13-9-17-21(30)22-6-3-7-27(17)19(13)26-16/h4-5,8-12H,3,6-7H2,1-2H3,(H,22,30)(H,25,29) KSLDAMNDQVGQHI-UHFFFAOYSA-N 167996 US9073926, 30 Ribosomal protein S6 kinase alpha-3 Homo sapiens 25 7.5 US Patent 10.7270/Q2BP01J6 aid1801413 US9073926 Boyer, SJ; Burke, J; Guo, X; Kirrane, Jr., TM; Snow, RJ; Zhang, Y Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167996 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167996&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 53242211 312525410 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 311905 CC(C)n1ncc2cc(NC(=O)c3ccc4cc5C(=O)NCC(C)(C)Cn5c4n3)cnc12 InChI=1S/C23H25N7O2/c1-13(2)30-19-15(9-26-30)7-16(10-24-19)27-21(31)17-6-5-14-8-18-22(32)25-11-23(3,4)12-29(18)20(14)28-17/h5-10,13H,11-12H2,1-4H3,(H,25,32)(H,27,31) BVXJEHLFTPAGNE-UHFFFAOYSA-N 167997 US9073926, 31 Ribosomal protein S6 kinase alpha-3 Homo sapiens 105 7.5 US Patent 10.7270/Q2BP01J6 aid1801413 US9073926 Boyer, SJ; Burke, J; Guo, X; Kirrane, Jr., TM; Snow, RJ; Zhang, Y Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167997 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167997&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 68322792 312525411 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 311906 CC1CCNC(=O)c2cc3ccc(nc3n12)C(=O)Nc1cnc2n(ncc2c1)C1CCOCC1 InChI=1S/C24H25N7O3/c1-14-4-7-25-24(33)20-11-15-2-3-19(29-22(15)30(14)20)23(32)28-17-10-16-12-27-31(21(16)26-13-17)18-5-8-34-9-6-18/h2-3,10-14,18H,4-9H2,1H3,(H,25,33)(H,28,32) HHBAYTAFBOSZPX-UHFFFAOYSA-N 167998 US9073926, 32 Ribosomal protein S6 kinase alpha-3 Homo sapiens 2.3 7.5 US Patent 10.7270/Q2BP01J6 aid1801413 US9073926 Boyer, SJ; Burke, J; Guo, X; Kirrane, Jr., TM; Snow, RJ; Zhang, Y Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167998 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167998&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 53242186 312525412 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 311907 O=C(Nc1cnc2n(ncc2c1)C1CCOCC1)c1ccc2cc3C(=O)NCCCn3c2n1 InChI=1S/C23H23N7O3/c31-22(18-3-2-14-11-19-23(32)24-6-1-7-29(19)21(14)28-18)27-16-10-15-12-26-30(20(15)25-13-16)17-4-8-33-9-5-17/h2-3,10-13,17H,1,4-9H2,(H,24,32)(H,27,31) ZDLIZWHPESZXOR-UHFFFAOYSA-N 167999 US9073926, 33 Ribosomal protein S6 kinase alpha-3 Homo sapiens 20 7.5 US Patent 10.7270/Q2BP01J6 aid1801413 US9073926 Boyer, SJ; Burke, J; Guo, X; Kirrane, Jr., TM; Snow, RJ; Zhang, Y Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167999 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167999&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 53242176 312525413 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 311908 CC1(C)CNC(=O)c2cc3ccc(nc3n2C1)C(=O)Nc1cnc2n(ncc2c1)C1CCOCC1 InChI=1S/C25H27N7O3/c1-25(2)13-27-24(34)20-10-15-3-4-19(30-22(15)31(20)14-25)23(33)29-17-9-16-11-28-32(21(16)26-12-17)18-5-7-35-8-6-18/h3-4,9-12,18H,5-8,13-14H2,1-2H3,(H,27,34)(H,29,33) ZISHPQSNRHWEJX-UHFFFAOYSA-N 168000 US9073926, 34 Ribosomal protein S6 kinase alpha-3 Homo sapiens 62 7.5 US Patent 10.7270/Q2BP01J6 aid1801413 US9073926 Boyer, SJ; Burke, J; Guo, X; Kirrane, Jr., TM; Snow, RJ; Zhang, Y Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168000 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168000&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 68322701 312525414 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 311909 CC1CCNC(=O)c2cc3ccc(nc3n12)C(=O)Nc1cnc2n(CC3CCOC3)ncc2c1 InChI=1S/C24H25N7O3/c1-14-4-6-25-24(33)20-9-16-2-3-19(29-22(16)31(14)20)23(32)28-18-8-17-10-27-30(21(17)26-11-18)12-15-5-7-34-13-15/h2-3,8-11,14-15H,4-7,12-13H2,1H3,(H,25,33)(H,28,32) GXLSDFNOALILGU-UHFFFAOYSA-N 168001 US9073926, 35 Ribosomal protein S6 kinase alpha-3 Homo sapiens 1.6 7.5 US Patent 10.7270/Q2BP01J6 aid1801413 US9073926 Boyer, SJ; Burke, J; Guo, X; Kirrane, Jr., TM; Snow, RJ; Zhang, Y Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168001 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168001&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 53242208 312525415 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 311910 O=C(Nc1cnc2n(CC3CCOC3)ncc2c1)c1ccc2cc3C(=O)NCCCn3c2n1 InChI=1S/C23H23N7O3/c31-22(18-3-2-15-9-19-23(32)24-5-1-6-29(19)21(15)28-18)27-17-8-16-10-26-30(20(16)25-11-17)12-14-4-7-33-13-14/h2-3,8-11,14H,1,4-7,12-13H2,(H,24,32)(H,27,31) DPQHQAXUONFMQP-UHFFFAOYSA-N 168002 US9073926, 36 Ribosomal protein S6 kinase alpha-3 Homo sapiens 13 7.5 US Patent 10.7270/Q2BP01J6 aid1801413 US9073926 Boyer, SJ; Burke, J; Guo, X; Kirrane, Jr., TM; Snow, RJ; Zhang, Y Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168002 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168002&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 53242188 312525416 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 311911 CC1(C)CNC(=O)c2cc3ccc(nc3n2C1)C(=O)Nc1cnc2n(CC3CCOC3)ncc2c1 InChI=1S/C25H27N7O3/c1-25(2)13-27-24(34)20-8-16-3-4-19(30-22(16)31(20)14-25)23(33)29-18-7-17-9-28-32(21(17)26-10-18)11-15-5-6-35-12-15/h3-4,7-10,15H,5-6,11-14H2,1-2H3,(H,27,34)(H,29,33) OBKXLPJQBTZBMA-UHFFFAOYSA-N 168003 US9073926, 37 Ribosomal protein S6 kinase alpha-3 Homo sapiens 25 7.5 US Patent 10.7270/Q2BP01J6 aid1801413 US9073926 Boyer, SJ; Burke, J; Guo, X; Kirrane, Jr., TM; Snow, RJ; Zhang, Y Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168003 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168003&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 68322702 312525417 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 311912 Cc1ccnc(NC(=O)c2ccc3cc4C(=O)NCCCn4c3n2)c1 InChI=1S/C18H17N5O2/c1-11-5-7-19-15(9-11)22-17(24)13-4-3-12-10-14-18(25)20-6-2-8-23(14)16(12)21-13/h3-5,7,9-10H,2,6,8H2,1H3,(H,20,25)(H,19,22,24) JKXDDXLLFULDSB-UHFFFAOYSA-N 168004 US9073926, 38 Ribosomal protein S6 kinase alpha-3 Homo sapiens 3.8 7.5 US Patent 10.7270/Q2BP01J6 aid1801413 US9073926 Boyer, SJ; Burke, J; Guo, X; Kirrane, Jr., TM; Snow, RJ; Zhang, Y Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168004 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168004&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 53242080 312525418 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 311913 CC1(C)CNC(=O)c2cc3ccc(nc3n2C1)C(=O)Nc1cnc2ccccc2c1 InChI=1S/C23H21N5O2/c1-23(2)12-25-22(30)19-10-15-7-8-18(27-20(15)28(19)13-23)21(29)26-16-9-14-5-3-4-6-17(14)24-11-16/h3-11H,12-13H2,1-2H3,(H,25,30)(H,26,29) QEQUMZRCCUEIIJ-UHFFFAOYSA-N 168005 US9073926, 39 Ribosomal protein S6 kinase alpha-3 Homo sapiens 91 7.5 US Patent 10.7270/Q2BP01J6 aid1801413 US9073926 Boyer, SJ; Burke, J; Guo, X; Kirrane, Jr., TM; Snow, RJ; Zhang, Y Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168005 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168005&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 68322694 312525419 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 311914 CC1CCNC(=O)c2cc3ccc(nc3n12)C(=O)Nc1cnn(C)c1 InChI=1S/C17H18N6O2/c1-10-5-6-18-17(25)14-7-11-3-4-13(21-15(11)23(10)14)16(24)20-12-8-19-22(2)9-12/h3-4,7-10H,5-6H2,1-2H3,(H,18,25)(H,20,24) IEWJUSIVLMUWOD-UHFFFAOYSA-N 168006 US9073926, 40 Ribosomal protein S6 kinase alpha-3 Homo sapiens 0.78 7.5 US Patent 10.7270/Q2BP01J6 aid1801413 US9073926 Boyer, SJ; Burke, J; Guo, X; Kirrane, Jr., TM; Snow, RJ; Zhang, Y Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168006 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168006&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 53242212 312525420 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 311915 Cn1cc(NC(=O)c2ccc3cc4C(=O)NCCCn4c3n2)cn1 InChI=1S/C16H16N6O2/c1-21-9-11(8-18-21)19-15(23)12-4-3-10-7-13-16(24)17-5-2-6-22(13)14(10)20-12/h3-4,7-9H,2,5-6H2,1H3,(H,17,24)(H,19,23) VGBPXKNBWHOARX-UHFFFAOYSA-N 168007 US9073926, 41 Ribosomal protein S6 kinase alpha-3 Homo sapiens 4.8 7.5 US Patent 10.7270/Q2BP01J6 aid1801413 US9073926 Boyer, SJ; Burke, J; Guo, X; Kirrane, Jr., TM; Snow, RJ; Zhang, Y Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168007 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168007&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 53242079 312525421 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 311916 Cn1cc(NC(=O)c2ccc3cc4C(=O)NCC(C)(C)Cn4c3n2)cn1 InChI=1S/C18H20N6O2/c1-18(2)9-19-17(26)14-6-11-4-5-13(22-15(11)24(14)10-18)16(25)21-12-7-20-23(3)8-12/h4-8H,9-10H2,1-3H3,(H,19,26)(H,21,25) HIYHAWWDKKWHQY-UHFFFAOYSA-N 168008 US9073926, 42 Ribosomal protein S6 kinase alpha-3 Homo sapiens 72 7.5 US Patent 10.7270/Q2BP01J6 aid1801413 US9073926 Boyer, SJ; Burke, J; Guo, X; Kirrane, Jr., TM; Snow, RJ; Zhang, Y Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168008 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168008&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 53242196 312525422 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 311917 CC1CCNC(=O)c2cc3ccc(nc3n12)C(=O)Nc1cnn(c1)C(C)(C)C InChI=1S/C20H24N6O2/c1-12-7-8-21-19(28)16-9-13-5-6-15(24-17(13)26(12)16)18(27)23-14-10-22-25(11-14)20(2,3)4/h5-6,9-12H,7-8H2,1-4H3,(H,21,28)(H,23,27) IIDUHZAGWFEQBW-UHFFFAOYSA-N 168009 US9073926, 43 Ribosomal protein S6 kinase alpha-3 Homo sapiens 1.1 7.5 US Patent 10.7270/Q2BP01J6 aid1801413 US9073926 Boyer, SJ; Burke, J; Guo, X; Kirrane, Jr., TM; Snow, RJ; Zhang, Y Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168009 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168009&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 53242219 312525423 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 311918 CC(C)(C)n1cc(NC(=O)c2ccc3cc4C(=O)NCCCn4c3n2)cn1 InChI=1S/C19H22N6O2/c1-19(2,3)25-11-13(10-21-25)22-17(26)14-6-5-12-9-15-18(27)20-7-4-8-24(15)16(12)23-14/h5-6,9-11H,4,7-8H2,1-3H3,(H,20,27)(H,22,26) BLIQORTUYKIMFR-UHFFFAOYSA-N 168010 US9073926, 44 Ribosomal protein S6 kinase alpha-3 Homo sapiens 9.7 7.5 US Patent 10.7270/Q2BP01J6 aid1801413 US9073926 Boyer, SJ; Burke, J; Guo, X; Kirrane, Jr., TM; Snow, RJ; Zhang, Y Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168010 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168010&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 53242218 312525424 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 311919 CC(C)(C)n1cc(NC(=O)c2ccc3cc4C(=O)NCC(C)(C)Cn4c3n2)cn1 InChI=1S/C21H26N6O2/c1-20(2,3)27-10-14(9-23-27)24-18(28)15-7-6-13-8-16-19(29)22-11-21(4,5)12-26(16)17(13)25-15/h6-10H,11-12H2,1-5H3,(H,22,29)(H,24,28) OJPHUPWPAOYDSF-UHFFFAOYSA-N 168011 US9073926, 45 Ribosomal protein S6 kinase alpha-3 Homo sapiens 50 7.5 US Patent 10.7270/Q2BP01J6 aid1801413 US9073926 Boyer, SJ; Burke, J; Guo, X; Kirrane, Jr., TM; Snow, RJ; Zhang, Y Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168011 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168011&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 89585680 312525425 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 311920 CC1CCNC(=O)c2cc3ccc(nc3n12)C(=O)Nc1cnn(Cc2ccccc2)c1 InChI=1S/C23H22N6O2/c1-15-9-10-24-23(31)20-11-17-7-8-19(27-21(17)29(15)20)22(30)26-18-12-25-28(14-18)13-16-5-3-2-4-6-16/h2-8,11-12,14-15H,9-10,13H2,1H3,(H,24,31)(H,26,30) VHYKGAUCYCNUBF-UHFFFAOYSA-N 168012 US9073926, 46 Ribosomal protein S6 kinase alpha-3 Homo sapiens 0.39 7.5 US Patent 10.7270/Q2BP01J6 aid1801413 US9073926 Boyer, SJ; Burke, J; Guo, X; Kirrane, Jr., TM; Snow, RJ; Zhang, Y Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168012 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168012&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 53242171 312525426 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 311921 O=C(Nc1cnn(Cc2ccccc2)c1)c1ccc2cc3C(=O)NCCCn3c2n1 InChI=1S/C22H20N6O2/c29-21(25-17-12-24-27(14-17)13-15-5-2-1-3-6-15)18-8-7-16-11-19-22(30)23-9-4-10-28(19)20(16)26-18/h1-3,5-8,11-12,14H,4,9-10,13H2,(H,23,30)(H,25,29) FVUHABBLIJXZMN-UHFFFAOYSA-N 168013 US9073926, 47 Ribosomal protein S6 kinase alpha-3 Homo sapiens 3.8 7.5 US Patent 10.7270/Q2BP01J6 aid1801413 US9073926 Boyer, SJ; Burke, J; Guo, X; Kirrane, Jr., TM; Snow, RJ; Zhang, Y Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168013 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168013&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 53242220 312525427 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 311922 CC1(C)CNC(=O)c2cc3ccc(nc3n2C1)C(=O)Nc1cnn(Cc2ccccc2)c1 InChI=1S/C24H24N6O2/c1-24(2)14-25-23(32)20-10-17-8-9-19(28-21(17)30(20)15-24)22(31)27-18-11-26-29(13-18)12-16-6-4-3-5-7-16/h3-11,13H,12,14-15H2,1-2H3,(H,25,32)(H,27,31) MISDLVFAYWWZLG-UHFFFAOYSA-N 168014 US9073926, 48 Ribosomal protein S6 kinase alpha-3 Homo sapiens 12 7.5 US Patent 10.7270/Q2BP01J6 aid1801413 US9073926 Boyer, SJ; Burke, J; Guo, X; Kirrane, Jr., TM; Snow, RJ; Zhang, Y Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168014 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168014&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 53242173 312525428 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 311923 Clc1cc(CN2CCOCC2)c2[nH]c(NC(=O)c3ccc4cc5C(=O)NCCCn5c4n3)nc2c1 InChI=1S/C24H24ClN7O3/c25-16-10-15(13-31-6-8-35-9-7-31)20-18(12-16)28-24(29-20)30-22(33)17-3-2-14-11-19-23(34)26-4-1-5-32(19)21(14)27-17/h2-3,10-12H,1,4-9,13H2,(H,26,34)(H2,28,29,30,33) XDFUUIPECUWQQZ-UHFFFAOYSA-N 168015 US9073926, 49 Ribosomal protein S6 kinase alpha-3 Homo sapiens 6.7 7.5 US Patent 10.7270/Q2BP01J6 aid1801413 US9073926 Boyer, SJ; Burke, J; Guo, X; Kirrane, Jr., TM; Snow, RJ; Zhang, Y Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168015 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168015&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 53242081 312525429 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 311924 CC1(C)CNC(=O)c2cc3ccc(nc3n2C1)C(=O)Nc1nc2cc(Cl)ccc2[nH]1 InChI=1S/C21H19ClN6O2/c1-21(2)9-23-19(30)16-7-11-3-5-14(24-17(11)28(16)10-21)18(29)27-20-25-13-6-4-12(22)8-15(13)26-20/h3-8H,9-10H2,1-2H3,(H,23,30)(H2,25,26,27,29) PNSOZKZGPSQHSN-UHFFFAOYSA-N 168016 US9073926, 50 Ribosomal protein S6 kinase alpha-3 Homo sapiens 55 7.5 US Patent 10.7270/Q2BP01J6 aid1801413 US9073926 Boyer, SJ; Burke, J; Guo, X; Kirrane, Jr., TM; Snow, RJ; Zhang, Y Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168016 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168016&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 89585657 312525430 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 311925 Cn1c(NC(=O)c2ccc3cc4C(=O)NCCCn4c3n2)nc2ccccc12 InChI=1S/C20H18N6O2/c1-25-15-6-3-2-5-13(15)23-20(25)24-18(27)14-8-7-12-11-16-19(28)21-9-4-10-26(16)17(12)22-14/h2-3,5-8,11H,4,9-10H2,1H3,(H,21,28)(H,23,24,27) UFFQKOHHXSMIRW-UHFFFAOYSA-N 168017 US9073926, 51 Ribosomal protein S6 kinase alpha-3 Homo sapiens 365 7.5 US Patent 10.7270/Q2BP01J6 aid1801413 US9073926 Boyer, SJ; Burke, J; Guo, X; Kirrane, Jr., TM; Snow, RJ; Zhang, Y Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168017 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168017&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 68322707 312525431 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 311926 Cn1c(NC(=O)c2ccc3cc4C(=O)NCC(C)(C)Cn4c3n2)nc2ccccc12 InChI=1S/C22H22N6O2/c1-22(2)11-23-20(30)17-10-13-8-9-15(24-18(13)28(17)12-22)19(29)26-21-25-14-6-4-5-7-16(14)27(21)3/h4-10H,11-12H2,1-3H3,(H,23,30)(H,25,26,29) RPBYOOGHPJSODY-UHFFFAOYSA-N 168018 US9073926, 52 Ribosomal protein S6 kinase alpha-3 Homo sapiens 2500 7.5 US Patent 10.7270/Q2BP01J6 aid1801413 US9073926 Boyer, SJ; Burke, J; Guo, X; Kirrane, Jr., TM; Snow, RJ; Zhang, Y Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168018 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168018&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 68322706 312525432 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 311927 CC(C)n1c(NC(=O)c2ccc3cc4C(=O)NCCCn4c3n2)nc2ccccc12 InChI=1S/C22H22N6O2/c1-13(2)28-17-7-4-3-6-15(17)25-22(28)26-20(29)16-9-8-14-12-18-21(30)23-10-5-11-27(18)19(14)24-16/h3-4,6-9,12-13H,5,10-11H2,1-2H3,(H,23,30)(H,25,26,29) YHWMUAMXBJBKPC-UHFFFAOYSA-N 168019 US9073926, 53 Ribosomal protein S6 kinase alpha-3 Homo sapiens 630 7.5 US Patent 10.7270/Q2BP01J6 aid1801413 US9073926 Boyer, SJ; Burke, J; Guo, X; Kirrane, Jr., TM; Snow, RJ; Zhang, Y Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168019 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168019&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 68322709 312525433 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 311928 CC(C)n1c(NC(=O)c2ccc3cc4C(=O)NCC(C)(C)Cn4c3n2)nc2ccccc12 InChI=1S/C24H26N6O2/c1-14(2)30-18-8-6-5-7-16(18)27-23(30)28-21(31)17-10-9-15-11-19-22(32)25-12-24(3,4)13-29(19)20(15)26-17/h5-11,14H,12-13H2,1-4H3,(H,25,32)(H,27,28,31) NQXBMUAFKYZLNH-UHFFFAOYSA-N 168020 US9073926, 54 Ribosomal protein S6 kinase alpha-3 Homo sapiens 1300 7.5 US Patent 10.7270/Q2BP01J6 aid1801413 US9073926 Boyer, SJ; Burke, J; Guo, X; Kirrane, Jr., TM; Snow, RJ; Zhang, Y Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168020 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168020&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 68322708 312525434 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 311929 CCn1c(NC(=O)c2ccc3cc4C(=O)NCCCn4c3n2)nc2ccccc12 InChI=1S/C21H20N6O2/c1-2-26-16-7-4-3-6-14(16)24-21(26)25-19(28)15-9-8-13-12-17-20(29)22-10-5-11-27(17)18(13)23-15/h3-4,6-9,12H,2,5,10-11H2,1H3,(H,22,29)(H,24,25,28) HNSNQBPXQBNWAY-UHFFFAOYSA-N 168021 US9073926, 55 Ribosomal protein S6 kinase alpha-3 Homo sapiens 140 7.5 US Patent 10.7270/Q2BP01J6 aid1801413 US9073926 Boyer, SJ; Burke, J; Guo, X; Kirrane, Jr., TM; Snow, RJ; Zhang, Y Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168021 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168021&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 68322704 312525435 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 311930 CCn1c(NC(=O)c2ccc3cc4C(=O)NCC(C)(C)Cn4c3n2)nc2ccccc12 InChI=1S/C23H24N6O2/c1-4-28-17-8-6-5-7-15(17)26-22(28)27-20(30)16-10-9-14-11-18-21(31)24-12-23(2,3)13-29(18)19(14)25-16/h5-11H,4,12-13H2,1-3H3,(H,24,31)(H,26,27,30) IFLNKMNSCZBCLT-UHFFFAOYSA-N 168022 US9073926, 56 Ribosomal protein S6 kinase alpha-3 Homo sapiens 195 7.5 US Patent 10.7270/Q2BP01J6 aid1801413 US9073926 Boyer, SJ; Burke, J; Guo, X; Kirrane, Jr., TM; Snow, RJ; Zhang, Y Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168022 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168022&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 68322705 312525436 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 311931 CN(C)CCCn1c(NC(=O)c2ccc3cc4C(=O)NCCCn4c3n2)nc2ccccc12 InChI=1S/C24H27N7O2/c1-29(2)12-6-14-31-19-8-4-3-7-17(19)27-24(31)28-22(32)18-10-9-16-15-20-23(33)25-11-5-13-30(20)21(16)26-18/h3-4,7-10,15H,5-6,11-14H2,1-2H3,(H,25,33)(H,27,28,32) IIHMKUHCZGYMCV-UHFFFAOYSA-N 168023 US9073926, 57 Ribosomal protein S6 kinase alpha-3 Homo sapiens 245 7.5 US Patent 10.7270/Q2BP01J6 aid1801413 US9073926 Boyer, SJ; Burke, J; Guo, X; Kirrane, Jr., TM; Snow, RJ; Zhang, Y Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168023 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168023&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 68322618 312525437 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 311932 CN(C)CCCn1c(NC(=O)c2ccc3cc4C(=O)NCC(C)(C)Cn4c3n2)nc2ccccc12 InChI=1S/C26H31N7O2/c1-26(2)15-27-24(35)21-14-17-10-11-19(28-22(17)33(21)16-26)23(34)30-25-29-18-8-5-6-9-20(18)32(25)13-7-12-31(3)4/h5-6,8-11,14H,7,12-13,15-16H2,1-4H3,(H,27,35)(H,29,30,34) BYNBSGRVCINSBK-UHFFFAOYSA-N 168024 US9073926, 58 Ribosomal protein S6 kinase alpha-3 Homo sapiens 2300 7.5 US Patent 10.7270/Q2BP01J6 aid1801413 US9073926 Boyer, SJ; Burke, J; Guo, X; Kirrane, Jr., TM; Snow, RJ; Zhang, Y Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168024 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168024&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 68322616 312525438 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 311933 C[C@@H]1CNC(=O)c2cc3ccc(nc3n12)C(=O)Nc1cnn(Cc2ccccc2)c1 InChI=1S/C22H20N6O2/c1-14-10-23-22(30)19-9-16-7-8-18(26-20(16)28(14)19)21(29)25-17-11-24-27(13-17)12-15-5-3-2-4-6-15/h2-9,11,13-14H,10,12H2,1H3,(H,23,30)(H,25,29)/t14-/m1/s1 GRKDQSJJVVIXFN-CQSZACIVSA-N 168025 US9073926, 59 Ribosomal protein S6 kinase alpha-3 Homo sapiens 0.2 7.5 US Patent 10.7270/Q2BP01J6 aid1801413 US9073926 Boyer, SJ; Burke, J; Guo, X; Kirrane, Jr., TM; Snow, RJ; Zhang, Y Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168025 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168025&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 53230343 312525439 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 311934 C[C@H]1CNC(=O)c2cc3ccc(nc3n12)C(=O)Nc1cnn(Cc2ccccc2)c1 InChI=1S/C22H20N6O2/c1-14-10-23-22(30)19-9-16-7-8-18(26-20(16)28(14)19)21(29)25-17-11-24-27(13-17)12-15-5-3-2-4-6-15/h2-9,11,13-14H,10,12H2,1H3,(H,23,30)(H,25,29)/t14-/m0/s1 GRKDQSJJVVIXFN-AWEZNQCLSA-N 168026 US9073926, 60 Ribosomal protein S6 kinase alpha-3 Homo sapiens 12 7.5 US Patent 10.7270/Q2BP01J6 aid1801413 US9073926 Boyer, SJ; Burke, J; Guo, X; Kirrane, Jr., TM; Snow, RJ; Zhang, Y Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168026 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168026&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 53242207 312525440 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 311935 C[C@H]1NC(=O)c2cc3ccc(nc3n2[C@H]1C)C(=O)Nc1cnn(Cc2ccccc2)c1 InChI=1S/C23H22N6O2/c1-14-15(2)29-20(23(31)25-14)10-17-8-9-19(27-21(17)29)22(30)26-18-11-24-28(13-18)12-16-6-4-3-5-7-16/h3-11,13-15H,12H2,1-2H3,(H,25,31)(H,26,30)/t14-,15+/m1/s1 UHXBEOZTLFAXRQ-CABCVRRESA-N 168027 US9073926, 61 Ribosomal protein S6 kinase alpha-3 Homo sapiens 0.34 7.5 US Patent 10.7270/Q2BP01J6 aid1801413 US9073926 Boyer, SJ; Burke, J; Guo, X; Kirrane, Jr., TM; Snow, RJ; Zhang, Y Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168027 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168027&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 53242189 312525441 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 311936 C[C@@H]1NC(=O)c2cc3ccc(nc3n2[C@H]1C)C(=O)Nc1cnn(Cc2ccccc2)c1 InChI=1S/C23H22N6O2/c1-14-15(2)29-20(23(31)25-14)10-17-8-9-19(27-21(17)29)22(30)26-18-11-24-28(13-18)12-16-6-4-3-5-7-16/h3-11,13-15H,12H2,1-2H3,(H,25,31)(H,26,30)/t14-,15-/m0/s1 UHXBEOZTLFAXRQ-GJZGRUSLSA-N 168028 US9073926, 62 Ribosomal protein S6 kinase alpha-3 Homo sapiens 3 7.5 US Patent 10.7270/Q2BP01J6 aid1801413 US9073926 Boyer, SJ; Burke, J; Guo, X; Kirrane, Jr., TM; Snow, RJ; Zhang, Y Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168028 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168028&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 67237338 312525442 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 311937 CC(C)n1ncc2cc(NC(=O)c3ccc4cc5C(=O)NC[C@H](C)n5c4n3)cnc12 InChI=1S/C21H21N7O2/c1-11(2)28-18-14(9-24-28)6-15(10-22-18)25-20(29)16-5-4-13-7-17-21(30)23-8-12(3)27(17)19(13)26-16/h4-7,9-12H,8H2,1-3H3,(H,23,30)(H,25,29)/t12-/m0/s1 MOAVQHGMQJPAOO-LBPRGKRZSA-N 168029 US9073926, 63 Ribosomal protein S6 kinase alpha-3 Homo sapiens 84 7.5 US Patent 10.7270/Q2BP01J6 aid1801413 US9073926 Boyer, SJ; Burke, J; Guo, X; Kirrane, Jr., TM; Snow, RJ; Zhang, Y Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168029 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168029&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 89585576 312525443 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 311938 C[C@@H]1CNC(=O)c2cc3ccc(nc3n12)C(=O)Nc1cnc2ccccc2c1 InChI=1S/C21H17N5O2/c1-12-10-23-21(28)18-9-14-6-7-17(25-19(14)26(12)18)20(27)24-15-8-13-4-2-3-5-16(13)22-11-15/h2-9,11-12H,10H2,1H3,(H,23,28)(H,24,27)/t12-/m1/s1 GNBSFKOHIIYQLM-GFCCVEGCSA-N 168030 US9073926, 64 Ribosomal protein S6 kinase alpha-3 Homo sapiens 3 7.5 US Patent 10.7270/Q2BP01J6 aid1801413 US9073926 Boyer, SJ; Burke, J; Guo, X; Kirrane, Jr., TM; Snow, RJ; Zhang, Y Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168030 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168030&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 53242197 312525444 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 311939 C[C@H]1CNC(=O)c2cc3ccc(nc3n12)C(=O)Nc1cnc2ccccc2c1 InChI=1S/C21H17N5O2/c1-12-10-23-21(28)18-9-14-6-7-17(25-19(14)26(12)18)20(27)24-15-8-13-4-2-3-5-16(13)22-11-15/h2-9,11-12H,10H2,1H3,(H,23,28)(H,24,27)/t12-/m0/s1 GNBSFKOHIIYQLM-LBPRGKRZSA-N 168031 US9073926, 65 Ribosomal protein S6 kinase alpha-3 Homo sapiens 34 7.5 US Patent 10.7270/Q2BP01J6 aid1801413 US9073926 Boyer, SJ; Burke, J; Guo, X; Kirrane, Jr., TM; Snow, RJ; Zhang, Y Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168031 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168031&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 89585776 312525445 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 311940 CC(C)n1ncc2cc(NC(=O)c3ccc4cc5C(=O)NC[C@@H](C)n5c4n3)cnc12 InChI=1S/C21H21N7O2/c1-11(2)28-18-14(9-24-28)6-15(10-22-18)25-20(29)16-5-4-13-7-17-21(30)23-8-12(3)27(17)19(13)26-16/h4-7,9-12H,8H2,1-3H3,(H,23,30)(H,25,29)/t12-/m1/s1 MOAVQHGMQJPAOO-GFCCVEGCSA-N 168032 US9073926, 66 Ribosomal protein S6 kinase alpha-3 Homo sapiens 4 7.5 US Patent 10.7270/Q2BP01J6 aid1801413 US9073926 Boyer, SJ; Burke, J; Guo, X; Kirrane, Jr., TM; Snow, RJ; Zhang, Y Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168032 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168032&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 53242190 312525446 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 311941 Clc1ccc2[nH]c(NC(=O)c3ccc4cc5C(=O)NCCCn5c4n3)nc2c1 InChI=1S/C19H15ClN6O2/c20-11-3-5-12-14(9-11)24-19(23-12)25-17(27)13-4-2-10-8-15-18(28)21-6-1-7-26(15)16(10)22-13/h2-5,8-9H,1,6-7H2,(H,21,28)(H2,23,24,25,27) ULXCPSCTMQCILD-UHFFFAOYSA-N 168033 US9073926, 67 Ribosomal protein S6 kinase alpha-3 Homo sapiens 6.1 7.5 US Patent 10.7270/Q2BP01J6 aid1801413 US9073926 Boyer, SJ; Burke, J; Guo, X; Kirrane, Jr., TM; Snow, RJ; Zhang, Y Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168033 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168033&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 68322676 312525447 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 311942 CC1CCNC(=O)c2cc3ccc(nc3n12)C(=O)Nc1cnn(Cc2ccncc2)c1 InChI=1S/C22H21N7O2/c1-14-4-9-24-22(31)19-10-16-2-3-18(27-20(16)29(14)19)21(30)26-17-11-25-28(13-17)12-15-5-7-23-8-6-15/h2-3,5-8,10-11,13-14H,4,9,12H2,1H3,(H,24,31)(H,26,30) BYNSQSZIQPYTMV-UHFFFAOYSA-N 168034 US9073926, 68 Ribosomal protein S6 kinase alpha-3 Homo sapiens 0.27 7.5 US Patent 10.7270/Q2BP01J6 aid1801413 US9073926 Boyer, SJ; Burke, J; Guo, X; Kirrane, Jr., TM; Snow, RJ; Zhang, Y Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168034 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168034&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 53242170 312525448 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 311943 CCn1c(NC(=O)c2ccc3cc4C(=O)NCCC(C)n4c3n2)nc2ccccc12 InChI=1S/C22H22N6O2/c1-3-27-17-7-5-4-6-15(17)25-22(27)26-20(29)16-9-8-14-12-18-21(30)23-11-10-13(2)28(18)19(14)24-16/h4-9,12-13H,3,10-11H2,1-2H3,(H,23,30)(H,25,26,29) JSMQKJNGBBRBMO-UHFFFAOYSA-N 168035 US9073926, 69 Ribosomal protein S6 kinase alpha-3 Homo sapiens 15 7.5 US Patent 10.7270/Q2BP01J6 aid1801413 US9073926 Boyer, SJ; Burke, J; Guo, X; Kirrane, Jr., TM; Snow, RJ; Zhang, Y Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168035 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168035&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 53242187 312525449 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 311944 CC1CCNC(=O)c2cc3ccc(nc3n12)C(=O)Nc1nc2ccccc2n1CCCN(C)C InChI=1S/C25H29N7O2/c1-16-11-12-26-24(34)21-15-17-9-10-19(27-22(17)32(16)21)23(33)29-25-28-18-7-4-5-8-20(18)31(25)14-6-13-30(2)3/h4-5,7-10,15-16H,6,11-14H2,1-3H3,(H,26,34)(H,28,29,33) NQFYAANUFXRFNE-UHFFFAOYSA-N 168036 US9073926, 70 Ribosomal protein S6 kinase alpha-3 Homo sapiens 27 7.5 US Patent 10.7270/Q2BP01J6 aid1801413 US9073926 Boyer, SJ; Burke, J; Guo, X; Kirrane, Jr., TM; Snow, RJ; Zhang, Y Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168036 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168036&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 68322699 312525450 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 311945 CCn1c(NC(=O)c2ccc3cc4C(=O)NC[C@H](C)n4c3n2)nc2ccccc12 InChI=1S/C21H20N6O2/c1-3-26-16-7-5-4-6-14(16)24-21(26)25-19(28)15-9-8-13-10-17-20(29)22-11-12(2)27(17)18(13)23-15/h4-10,12H,3,11H2,1-2H3,(H,22,29)(H,24,25,28)/t12-/m0/s1 QKXWJSXDKHCSDT-LBPRGKRZSA-N 168037 US9073926, 71 Ribosomal protein S6 kinase alpha-3 Homo sapiens 54.5 7.5 US Patent 10.7270/Q2BP01J6 aid1801413 US9073926 Boyer, SJ; Burke, J; Guo, X; Kirrane, Jr., TM; Snow, RJ; Zhang, Y Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168037 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168037&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 89585684 312525451 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 311946 CCn1c(NC(=O)c2ccc3cc4C(=O)NC[C@@H](C)n4c3n2)nc2ccccc12 InChI=1S/C21H20N6O2/c1-3-26-16-7-5-4-6-14(16)24-21(26)25-19(28)15-9-8-13-10-17-20(29)22-11-12(2)27(17)18(13)23-15/h4-10,12H,3,11H2,1-2H3,(H,22,29)(H,24,25,28)/t12-/m1/s1 QKXWJSXDKHCSDT-GFCCVEGCSA-N 168038 US9073926, 72 Ribosomal protein S6 kinase alpha-3 Homo sapiens 26.5 7.5 US Patent 10.7270/Q2BP01J6 aid1801413 US9073926 Boyer, SJ; Burke, J; Guo, X; Kirrane, Jr., TM; Snow, RJ; Zhang, Y Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168038 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168038&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 68322697 312525452 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 311947 CCn1c(NC(=O)c2ccc3cc4C(=O)N[C@H](C)[C@H](C)n4c3n2)nc2ccccc12 InChI=1S/C22H22N6O2/c1-4-27-17-8-6-5-7-15(17)25-22(27)26-20(29)16-10-9-14-11-18-21(30)23-12(2)13(3)28(18)19(14)24-16/h5-13H,4H2,1-3H3,(H,23,30)(H,25,26,29)/t12-,13+/m1/s1 CSFFHTKDUCGKJD-OLZOCXBDSA-N 168039 US9073926, 73 Ribosomal protein S6 kinase alpha-3 Homo sapiens 11.6 7.5 US Patent 10.7270/Q2BP01J6 aid1801413 US9073926 Boyer, SJ; Burke, J; Guo, X; Kirrane, Jr., TM; Snow, RJ; Zhang, Y Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168039 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168039&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 53242180 312525453 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 311948 CCn1c(NC(=O)c2ccc3cc4C(=O)N[C@@H](C)[C@H](C)n4c3n2)nc2ccccc12 InChI=1S/C22H22N6O2/c1-4-27-17-8-6-5-7-15(17)25-22(27)26-20(29)16-10-9-14-11-18-21(30)23-12(2)13(3)28(18)19(14)24-16/h5-13H,4H2,1-3H3,(H,23,30)(H,25,26,29)/t12-,13-/m0/s1 CSFFHTKDUCGKJD-STQMWFEESA-N 168040 US9073926, 74 Ribosomal protein S6 kinase alpha-3 Homo sapiens 1111 7.5 US Patent 10.7270/Q2BP01J6 aid1801413 US9073926 Boyer, SJ; Burke, J; Guo, X; Kirrane, Jr., TM; Snow, RJ; Zhang, Y Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168040 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168040&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 89585638 312525454 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 311949 C[C@H]1CNC(=O)c2cc3ccc(nc3n12)C(=O)Nc1nc2ccccc2n1CCCN(C)C InChI=1S/C24H27N7O2/c1-15-14-25-23(33)20-13-16-9-10-18(26-21(16)31(15)20)22(32)28-24-27-17-7-4-5-8-19(17)30(24)12-6-11-29(2)3/h4-5,7-10,13,15H,6,11-12,14H2,1-3H3,(H,25,33)(H,27,28,32)/t15-/m0/s1 GJDUQWWYWMTDRL-HNNXBMFYSA-N 168041 US9073926, 75 Ribosomal protein S6 kinase alpha-3 Homo sapiens 265 7.5 US Patent 10.7270/Q2BP01J6 aid1801413 US9073926 Boyer, SJ; Burke, J; Guo, X; Kirrane, Jr., TM; Snow, RJ; Zhang, Y Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168041 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168041&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 89585755 312525455 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 311950 C[C@@H]1CNC(=O)c2cc3ccc(nc3n12)C(=O)Nc1nc2ccccc2n1CCCN(C)C InChI=1S/C24H27N7O2/c1-15-14-25-23(33)20-13-16-9-10-18(26-21(16)31(15)20)22(32)28-24-27-17-7-4-5-8-19(17)30(24)12-6-11-29(2)3/h4-5,7-10,13,15H,6,11-12,14H2,1-3H3,(H,25,33)(H,27,28,32)/t15-/m1/s1 GJDUQWWYWMTDRL-OAHLLOKOSA-N 168042 US9073926, 76 Ribosomal protein S6 kinase alpha-3 Homo sapiens 54 7.5 US Patent 10.7270/Q2BP01J6 aid1801413 US9073926 Boyer, SJ; Burke, J; Guo, X; Kirrane, Jr., TM; Snow, RJ; Zhang, Y Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168042 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168042&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 68322698 312525456 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 311951 C[C@H]1NC(=O)c2cc3ccc(nc3n2[C@H]1C)C(=O)Nc1nc2ccccc2n1CCCN(C)C InChI=1S/C25H29N7O2/c1-15-16(2)32-21(24(34)26-15)14-17-10-11-19(27-22(17)32)23(33)29-25-28-18-8-5-6-9-20(18)31(25)13-7-12-30(3)4/h5-6,8-11,14-16H,7,12-13H2,1-4H3,(H,26,34)(H,28,29,33)/t15-,16+/m1/s1 HZICFZZGLWKOAR-CVEARBPZSA-N 168043 US9073926, 77 Ribosomal protein S6 kinase alpha-3 Homo sapiens 29 7.5 US Patent 10.7270/Q2BP01J6 aid1801413 US9073926 Boyer, SJ; Burke, J; Guo, X; Kirrane, Jr., TM; Snow, RJ; Zhang, Y Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168043 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168043&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 89585587 312525457 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 311952 C[C@@H]1NC(=O)c2cc3ccc(nc3n2[C@H]1C)C(=O)Nc1nc2ccccc2n1CCCN(C)C InChI=1S/C25H29N7O2/c1-15-16(2)32-21(24(34)26-15)14-17-10-11-19(27-22(17)32)23(33)29-25-28-18-8-5-6-9-20(18)31(25)13-7-12-30(3)4/h5-6,8-11,14-16H,7,12-13H2,1-4H3,(H,26,34)(H,28,29,33)/t15-,16-/m0/s1 HZICFZZGLWKOAR-HOTGVXAUSA-N 168044 US9073926, 78 Ribosomal protein S6 kinase alpha-3 Homo sapiens 205 7.5 US Patent 10.7270/Q2BP01J6 aid1801413 US9073926 Boyer, SJ; Burke, J; Guo, X; Kirrane, Jr., TM; Snow, RJ; Zhang, Y Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168044 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168044&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 89585789 312525458 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 311953 CC(C)(C)c1cc(NC(=O)c2ccc3cc4C(=O)NCCCn4c3n2)no1 InChI=1S/C19H21N5O3/c1-19(2,3)14-10-15(23-27-14)22-17(25)12-6-5-11-9-13-18(26)20-7-4-8-24(13)16(11)21-12/h5-6,9-10H,4,7-8H2,1-3H3,(H,20,26)(H,22,23,25) ZMEYPNTUCZBQQN-UHFFFAOYSA-N 168045 US9073926, 79 Ribosomal protein S6 kinase alpha-3 Homo sapiens 19 7.5 US Patent 10.7270/Q2BP01J6 aid1801413 US9073926 Boyer, SJ; Burke, J; Guo, X; Kirrane, Jr., TM; Snow, RJ; Zhang, Y Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168045 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168045&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 68322609 312525459 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 311954 Cc1cc(NC(=O)c2ccc3cc4C(=O)NCCCn4c3n2)no1 InChI=1S/C16H15N5O3/c1-9-7-13(20-24-9)19-15(22)11-4-3-10-8-12-16(23)17-5-2-6-21(12)14(10)18-11/h3-4,7-8H,2,5-6H2,1H3,(H,17,23)(H,19,20,22) BEWMLXSGKYXKGS-UHFFFAOYSA-N 168046 US9073926, 80 Ribosomal protein S6 kinase alpha-3 Homo sapiens 19 7.5 US Patent 10.7270/Q2BP01J6 aid1801413 US9073926 Boyer, SJ; Burke, J; Guo, X; Kirrane, Jr., TM; Snow, RJ; Zhang, Y Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168046 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168046&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 53242193 312525460 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 311955 O=C(Nc1cc(no1)-c1ccccc1)c1ccc2cc3C(=O)NCCCn3c2n1 InChI=1S/C21H17N5O3/c27-20(24-18-12-16(25-29-18)13-5-2-1-3-6-13)15-8-7-14-11-17-21(28)22-9-4-10-26(17)19(14)23-15/h1-3,5-8,11-12H,4,9-10H2,(H,22,28)(H,24,27) ZCRIUCAFIYNTRU-UHFFFAOYSA-N 168047 US9073926, 81 Ribosomal protein S6 kinase alpha-3 Homo sapiens 4.3 7.5 US Patent 10.7270/Q2BP01J6 aid1801413 US9073926 Boyer, SJ; Burke, J; Guo, X; Kirrane, Jr., TM; Snow, RJ; Zhang, Y Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168047 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168047&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 89585614 312525461 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 311956 CC1CCNC(=O)c2cc3ccc(nc3n12)C(=O)Nc1cc(C)on1 InChI=1S/C17H17N5O3/c1-9-5-6-18-17(24)13-8-11-3-4-12(19-15(11)22(9)13)16(23)20-14-7-10(2)25-21-14/h3-4,7-9H,5-6H2,1-2H3,(H,18,24)(H,20,21,23) NVVCEADQXFTDLA-UHFFFAOYSA-N 168048 US9073926, 82 Ribosomal protein S6 kinase alpha-3 Homo sapiens 5.2 7.5 US Patent 10.7270/Q2BP01J6 aid1801413 US9073926 Boyer, SJ; Burke, J; Guo, X; Kirrane, Jr., TM; Snow, RJ; Zhang, Y Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168048 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168048&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 53242181 312525462 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 311957 C[C@H]1CNC(=O)c2cc3ccc(nc3n12)C(=O)Nc1cc(C)on1 InChI=1S/C16H15N5O3/c1-8-7-17-16(23)12-6-10-3-4-11(18-14(10)21(8)12)15(22)19-13-5-9(2)24-20-13/h3-6,8H,7H2,1-2H3,(H,17,23)(H,19,20,22)/t8-/m0/s1 UVDOSWDIUBQDQI-QMMMGPOBSA-N 168049 US9073926, 83 Ribosomal protein S6 kinase alpha-3 Homo sapiens 380 7.5 US Patent 10.7270/Q2BP01J6 aid1801413 US9073926 Boyer, SJ; Burke, J; Guo, X; Kirrane, Jr., TM; Snow, RJ; Zhang, Y Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168049 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168049&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 89585726 312525463 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 311958 C[C@@H]1CNC(=O)c2cc3ccc(nc3n12)C(=O)Nc1cc(C)on1 InChI=1S/C16H15N5O3/c1-8-7-17-16(23)12-6-10-3-4-11(18-14(10)21(8)12)15(22)19-13-5-9(2)24-20-13/h3-6,8H,7H2,1-2H3,(H,17,23)(H,19,20,22)/t8-/m1/s1 UVDOSWDIUBQDQI-MRVPVSSYSA-N 168050 US9073926, 84 Ribosomal protein S6 kinase alpha-3 Homo sapiens 6.6 7.5 US Patent 10.7270/Q2BP01J6 aid1801413 US9073926 Boyer, SJ; Burke, J; Guo, X; Kirrane, Jr., TM; Snow, RJ; Zhang, Y Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168050 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168050&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 53242194 312525464 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 311959 C[C@H]1NC(=O)c2cc3ccc(nc3n2[C@H]1C)C(=O)Nc1cc(C)on1 InChI=1S/C17H17N5O3/c1-8-6-14(21-25-8)20-16(23)12-5-4-11-7-13-17(24)18-9(2)10(3)22(13)15(11)19-12/h4-7,9-10H,1-3H3,(H,18,24)(H,20,21,23)/t9-,10+/m1/s1 UJUORBDBVOLWSF-ZJUUUORDSA-N 168051 US9073926, 85 Ribosomal protein S6 kinase alpha-3 Homo sapiens 2.6 7.5 US Patent 10.7270/Q2BP01J6 aid1801413 US9073926 Boyer, SJ; Burke, J; Guo, X; Kirrane, Jr., TM; Snow, RJ; Zhang, Y Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168051 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168051&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 53242184 312525465 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 311960 C[C@@H]1NC(=O)c2cc3ccc(nc3n2[C@H]1C)C(=O)Nc1cc(C)on1 InChI=1S/C17H17N5O3/c1-8-6-14(21-25-8)20-16(23)12-5-4-11-7-13-17(24)18-9(2)10(3)22(13)15(11)19-12/h4-7,9-10H,1-3H3,(H,18,24)(H,20,21,23)/t9-,10-/m0/s1 UJUORBDBVOLWSF-UWVGGRQHSA-N 168052 US9073926, 86 Ribosomal protein S6 kinase alpha-3 Homo sapiens 110 7.5 US Patent 10.7270/Q2BP01J6 aid1801413 US9073926 Boyer, SJ; Burke, J; Guo, X; Kirrane, Jr., TM; Snow, RJ; Zhang, Y Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168052 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168052&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 89585775 312525466 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 311961 CC(C)(C)c1cc(NC(=O)c2ccc3cc4C(=O)NCC(C)(C)Cn4c3n2)no1 InChI=1S/C21H25N5O3/c1-20(2,3)15-9-16(25-29-15)24-18(27)13-7-6-12-8-14-19(28)22-10-21(4,5)11-26(14)17(12)23-13/h6-9H,10-11H2,1-5H3,(H,22,28)(H,24,25,27) DQGHTEPCNAKPFL-UHFFFAOYSA-N 168053 US9073926, 87 Ribosomal protein S6 kinase alpha-3 Homo sapiens 175 7.5 US Patent 10.7270/Q2BP01J6 aid1801413 US9073926 Boyer, SJ; Burke, J; Guo, X; Kirrane, Jr., TM; Snow, RJ; Zhang, Y Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168053 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168053&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 68322672 312525467 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 311962 CCc1cc(NC(=O)c2ccc3cc4C(=O)NCC(C)(C)Cn4c3n2)no1 InChI=1S/C19H21N5O3/c1-4-12-8-15(23-27-12)22-17(25)13-6-5-11-7-14-18(26)20-9-19(2,3)10-24(14)16(11)21-13/h5-8H,4,9-10H2,1-3H3,(H,20,26)(H,22,23,25) UQTTUPZZXWDOQT-UHFFFAOYSA-N 168054 US9073926, 88 Ribosomal protein S6 kinase alpha-3 Homo sapiens 109 7.5 US Patent 10.7270/Q2BP01J6 aid1801413 US9073926 Boyer, SJ; Burke, J; Guo, X; Kirrane, Jr., TM; Snow, RJ; Zhang, Y Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168054 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168054&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 68322679 312525468 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 311963 CC(C)c1cc(NC(=O)c2ccc3cc4C(=O)NCC(C)(C)Cn4c3n2)no1 InChI=1S/C20H23N5O3/c1-11(2)15-8-16(24-28-15)23-18(26)13-6-5-12-7-14-19(27)21-9-20(3,4)10-25(14)17(12)22-13/h5-8,11H,9-10H2,1-4H3,(H,21,27)(H,23,24,26) LPZFCJCYTYLTNK-UHFFFAOYSA-N 168055 US9073926, 89 Ribosomal protein S6 kinase alpha-3 Homo sapiens 125 7.5 US Patent 10.7270/Q2BP01J6 aid1801413 US9073926 Boyer, SJ; Burke, J; Guo, X; Kirrane, Jr., TM; Snow, RJ; Zhang, Y Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168055 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168055&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 68322680 312525469 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 311964 CC1(C)CNC(=O)c2cc3ccc(nc3n2C1)C(=O)Nc1cc(on1)C1CC1 InChI=1S/C20H21N5O3/c1-20(2)9-21-19(27)14-7-12-5-6-13(22-17(12)25(14)10-20)18(26)23-16-8-15(28-24-16)11-3-4-11/h5-8,11H,3-4,9-10H2,1-2H3,(H,21,27)(H,23,24,26) GXSOLYTVGZNXTL-UHFFFAOYSA-N 168056 US9073926, 90 Ribosomal protein S6 kinase alpha-3 Homo sapiens 43 7.5 US Patent 10.7270/Q2BP01J6 aid1801413 US9073926 Boyer, SJ; Burke, J; Guo, X; Kirrane, Jr., TM; Snow, RJ; Zhang, Y Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168056 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168056&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 68322682 312525470 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 311965 Cc1cc(NC(=O)c2ccc3cc4C(=O)NCC(C)(C)Cn4c3n2)no1 InChI=1S/C18H19N5O3/c1-10-6-14(22-26-10)21-16(24)12-5-4-11-7-13-17(25)19-8-18(2,3)9-23(13)15(11)20-12/h4-7H,8-9H2,1-3H3,(H,19,25)(H,21,22,24) DLOOMMVSICCHTJ-UHFFFAOYSA-N 168057 US9073926, 91 Ribosomal protein S6 kinase alpha-3 Homo sapiens 395 7.5 US Patent 10.7270/Q2BP01J6 aid1801413 US9073926 Boyer, SJ; Burke, J; Guo, X; Kirrane, Jr., TM; Snow, RJ; Zhang, Y Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168057 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168057&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 68322600 312525471 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 311966 CC1(C)CNC(=O)c2cc3ccc(nc3n2C1)C(=O)Nc1cc(on1)-c1ccccc1 InChI=1S/C23H21N5O3/c1-23(2)12-24-22(30)17-10-15-8-9-16(25-20(15)28(17)13-23)21(29)26-19-11-18(31-27-19)14-6-4-3-5-7-14/h3-11H,12-13H2,1-2H3,(H,24,30)(H,26,27,29) JSBSVYKRXJJWRJ-UHFFFAOYSA-N 168058 US9073926, 92 Ribosomal protein S6 kinase alpha-3 Homo sapiens 502 7.5 US Patent 10.7270/Q2BP01J6 aid1801413 US9073926 Boyer, SJ; Burke, J; Guo, X; Kirrane, Jr., TM; Snow, RJ; Zhang, Y Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168058 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168058&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 68322601 312525472 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 311967 CC1(C)CNC(=O)c2cc3ccc(nc3n2C1)C(=O)Nc1cc(Cc2ccccc2)on1 InChI=1S/C24H23N5O3/c1-24(2)13-25-23(31)19-11-16-8-9-18(26-21(16)29(19)14-24)22(30)27-20-12-17(32-28-20)10-15-6-4-3-5-7-15/h3-9,11-12H,10,13-14H2,1-2H3,(H,25,31)(H,27,28,30) JIHBFKNLUCQAKL-UHFFFAOYSA-N 168059 US9073926, 93 Ribosomal protein S6 kinase alpha-3 Homo sapiens 360 7.5 US Patent 10.7270/Q2BP01J6 aid1801413 US9073926 Boyer, SJ; Burke, J; Guo, X; Kirrane, Jr., TM; Snow, RJ; Zhang, Y Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168059 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168059&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 68322603 312525473 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 311968 CC1CCNC(=O)c2cc3ccc(nc3n12)C(=O)Nc1cc(Cc2ccccc2)on1 InChI=1S/C23H21N5O3/c1-14-9-10-24-23(30)19-12-16-7-8-18(25-21(16)28(14)19)22(29)26-20-13-17(31-27-20)11-15-5-3-2-4-6-15/h2-8,12-14H,9-11H2,1H3,(H,24,30)(H,26,27,29) AKWFWIHZLMHBGJ-UHFFFAOYSA-N 168060 US9073926, 94 Ribosomal protein S6 kinase alpha-3 Homo sapiens 3.3 7.5 US Patent 10.7270/Q2BP01J6 aid1801413 US9073926 Boyer, SJ; Burke, J; Guo, X; Kirrane, Jr., TM; Snow, RJ; Zhang, Y Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168060 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168060&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 53242177 312525474 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 311969 O=C(Nc1cc(Cc2ccccc2)no1)c1ccc2cc3C(=O)NCCCn3c2n1 InChI=1S/C22H19N5O3/c28-21(25-19-13-16(26-30-19)11-14-5-2-1-3-6-14)17-8-7-15-12-18-22(29)23-9-4-10-27(18)20(15)24-17/h1-3,5-8,12-13H,4,9-11H2,(H,23,29)(H,25,28) MJQGDJQVIHPYTB-UHFFFAOYSA-N 168061 US9073926, 95 Ribosomal protein S6 kinase alpha-3 Homo sapiens 3.6 7.5 US Patent 10.7270/Q2BP01J6 aid1801413 US9073926 Boyer, SJ; Burke, J; Guo, X; Kirrane, Jr., TM; Snow, RJ; Zhang, Y Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168061 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168061&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 53242183 312525475 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 311970 CC1CCNC(=O)c2cc3ccc(nc3n12)C(=O)Nc1cc(Cc2ccccc2)no1 InChI=1S/C23H21N5O3/c1-14-9-10-24-23(30)19-12-16-7-8-18(25-21(16)28(14)19)22(29)26-20-13-17(27-31-20)11-15-5-3-2-4-6-15/h2-8,12-14H,9-11H2,1H3,(H,24,30)(H,26,29) LPPKYSFULWRWFC-UHFFFAOYSA-N 168062 US9073926, 96 Ribosomal protein S6 kinase alpha-3 Homo sapiens 13 7.5 US Patent 10.7270/Q2BP01J6 aid1801413 US9073926 Boyer, SJ; Burke, J; Guo, X; Kirrane, Jr., TM; Snow, RJ; Zhang, Y Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168062 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168062&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 53242185 312525476 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 311971 C[C@H]1CNC(=O)c2cc3ccc(nc3n12)C(=O)Nc1cc(Cc2ccccc2)on1 InChI=1S/C22H19N5O3/c1-13-12-23-22(29)18-10-15-7-8-17(24-20(15)27(13)18)21(28)25-19-11-16(30-26-19)9-14-5-3-2-4-6-14/h2-8,10-11,13H,9,12H2,1H3,(H,23,29)(H,25,26,28)/t13-/m0/s1 ZGXCDVSLCJXLMT-ZDUSSCGKSA-N 168063 US9073926, 97 Ribosomal protein S6 kinase alpha-3 Homo sapiens 490 7.5 US Patent 10.7270/Q2BP01J6 aid1801413 US9073926 Boyer, SJ; Burke, J; Guo, X; Kirrane, Jr., TM; Snow, RJ; Zhang, Y Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168063 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168063&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 89585603 312525477 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 311972 C[C@@H]1CNC(=O)c2cc3ccc(nc3n12)C(=O)Nc1cc(Cc2ccccc2)on1 InChI=1S/C22H19N5O3/c1-13-12-23-22(29)18-10-15-7-8-17(24-20(15)27(13)18)21(28)25-19-11-16(30-26-19)9-14-5-3-2-4-6-14/h2-8,10-11,13H,9,12H2,1H3,(H,23,29)(H,25,26,28)/t13-/m1/s1 ZGXCDVSLCJXLMT-CYBMUJFWSA-N 168064 US9073926, 98 Ribosomal protein S6 kinase alpha-3 Homo sapiens 3.9 7.5 US Patent 10.7270/Q2BP01J6 aid1801413 US9073926 Boyer, SJ; Burke, J; Guo, X; Kirrane, Jr., TM; Snow, RJ; Zhang, Y Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168064 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168064&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 53242209 312525478 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 311973 C[C@H]1NC(=O)c2cc3ccc(nc3n2[C@H]1C)C(=O)Nc1cc(Cc2ccccc2)on1 InChI=1S/C23H21N5O3/c1-13-14(2)28-19(23(30)24-13)11-16-8-9-18(25-21(16)28)22(29)26-20-12-17(31-27-20)10-15-6-4-3-5-7-15/h3-9,11-14H,10H2,1-2H3,(H,24,30)(H,26,27,29)/t13-,14+/m1/s1 KMZHUPNJAVFPRF-KGLIPLIRSA-N 168065 US9073926, 99 Ribosomal protein S6 kinase alpha-3 Homo sapiens 5.1 7.5 US Patent 10.7270/Q2BP01J6 aid1801413 US9073926 Boyer, SJ; Burke, J; Guo, X; Kirrane, Jr., TM; Snow, RJ; Zhang, Y Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168065 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168065&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 53242210 312525479 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 311974 C[C@@H]1NC(=O)c2cc3ccc(nc3n2[C@H]1C)C(=O)Nc1cc(Cc2ccccc2)on1 InChI=1S/C23H21N5O3/c1-13-14(2)28-19(23(30)24-13)11-16-8-9-18(25-21(16)28)22(29)26-20-12-17(31-27-20)10-15-6-4-3-5-7-15/h3-9,11-14H,10H2,1-2H3,(H,24,30)(H,26,27,29)/t13-,14-/m0/s1 KMZHUPNJAVFPRF-KBPBESRZSA-N 168066 US9073926, 100 Ribosomal protein S6 kinase alpha-3 Homo sapiens 57 7.5 US Patent 10.7270/Q2BP01J6 aid1801413 US9073926 Boyer, SJ; Burke, J; Guo, X; Kirrane, Jr., TM; Snow, RJ; Zhang, Y Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168066 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168066&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 89585575 312525480 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 311975 CC1CNC(=O)c2cc3ccc(nc3n12)C(=O)Nc1cccnc1 InChI=1S/C17H15N5O2/c1-10-8-19-17(24)14-7-11-4-5-13(21-15(11)22(10)14)16(23)20-12-3-2-6-18-9-12/h2-7,9-10H,8H2,1H3,(H,19,24)(H,20,23) XSSZBQFGRSGRTN-UHFFFAOYSA-N 168067 US9073926, 101 Ribosomal protein S6 kinase alpha-3 Homo sapiens 120 7.5 US Patent 10.7270/Q2BP01J6 aid1801413 US9073926 Boyer, SJ; Burke, J; Guo, X; Kirrane, Jr., TM; Snow, RJ; Zhang, Y Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168067 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168067&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 53242195 312525481 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 311976 CNC(=O)c1csc(NC(=O)c2ccc3cc4C(=O)NCC(C)n4c3n2)n1 InChI=1S/C17H16N6O3S/c1-8-6-19-16(26)12-5-9-3-4-10(20-13(9)23(8)12)15(25)22-17-21-11(7-27-17)14(24)18-2/h3-5,7-8H,6H2,1-2H3,(H,18,24)(H,19,26)(H,21,22,25) URMDJMKUFXNKRG-UHFFFAOYSA-N 168068 US9073926, 102 Ribosomal protein S6 kinase alpha-3 Homo sapiens 130 7.5 US Patent 10.7270/Q2BP01J6 aid1801413 US9073926 Boyer, SJ; Burke, J; Guo, X; Kirrane, Jr., TM; Snow, RJ; Zhang, Y Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168068 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168068&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 88936516 312525482 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 311977 CC1CNC(=O)c2cc3ccc(nc3n12)C(=O)Nc1nccs1 InChI=1S/C15H13N5O2S/c1-8-7-17-14(22)11-6-9-2-3-10(18-12(9)20(8)11)13(21)19-15-16-4-5-23-15/h2-6,8H,7H2,1H3,(H,17,22)(H,16,19,21) LOVYPHDMDZPQDA-UHFFFAOYSA-N 168069 US9073926, 103 Ribosomal protein S6 kinase alpha-3 Homo sapiens 330 7.5 US Patent 10.7270/Q2BP01J6 aid1801413 US9073926 Boyer, SJ; Burke, J; Guo, X; Kirrane, Jr., TM; Snow, RJ; Zhang, Y Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168069 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168069&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 88936517 312525483 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 311978 Cn1cc(NC(=O)c2ccc3cc4C(=O)NCCCn4c3n2)nc1C(=O)NC1CCCC1 InChI=1S/C22H25N7O3/c1-28-12-17(26-19(28)22(32)24-14-5-2-3-6-14)27-20(30)15-8-7-13-11-16-21(31)23-9-4-10-29(16)18(13)25-15/h7-8,11-12,14H,2-6,9-10H2,1H3,(H,23,31)(H,24,32)(H,27,30) ZAAULFKSCDOLLO-UHFFFAOYSA-N 168070 US9073926, 104 Ribosomal protein S6 kinase alpha-3 Homo sapiens 1.6 7.5 US Patent 10.7270/Q2BP01J6 aid1801413 US9073926 Boyer, SJ; Burke, J; Guo, X; Kirrane, Jr., TM; Snow, RJ; Zhang, Y Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168070 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168070&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 67236497 312525484 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 311979 O=C(Nc1cccc(c1)-c1c[nH]cn1)c1ccc2cc3C(=O)NCCCn3c2n1 InChI=1S/C21H18N6O2/c28-20(25-15-4-1-3-13(9-15)17-11-22-12-24-17)16-6-5-14-10-18-21(29)23-7-2-8-27(18)19(14)26-16/h1,3-6,9-12H,2,7-8H2,(H,22,24)(H,23,29)(H,25,28) YLSPAUGOMPCCCJ-UHFFFAOYSA-N 168071 US9073926, 105 Ribosomal protein S6 kinase alpha-3 Homo sapiens 17 7.5 US Patent 10.7270/Q2BP01J6 aid1801413 US9073926 Boyer, SJ; Burke, J; Guo, X; Kirrane, Jr., TM; Snow, RJ; Zhang, Y Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168071 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168071&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 67236976 312525485 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 412047 Nc1ccc(cn1)-c1ccc2ncc3c(n(-c4cccc(c4)C(F)(F)F)c(=O)[nH]c3=O)c2n1 InChI=1S/C22H13F3N6O2/c23-22(24,25)12-2-1-3-13(8-12)31-19-14(20(32)30-21(31)33)10-27-16-6-5-15(29-18(16)19)11-4-7-17(26)28-9-11/h1-10H,(H2,26,28)(H,30,32,33) OIOOKLQHEDGJOE-UHFFFAOYSA-N 236557 US9365572, 5 Ribosomal protein S6 kinase alpha-3 Homo sapiens >10000 7.5 28.00 C US Patent 10.7270/Q20C4TNC aid1803088 US9365572 Wu, F; Shu, C Xuanzhu Pharma Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=236557 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=236557&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 129012341 340130144 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 422046 Oc1ccc(NN=C2C(=O)NC(=O)NC2=O)cc1 InChI=1S/C10H8N4O4/c15-6-3-1-5(2-4-6)13-14-7-8(16)11-10(18)12-9(7)17/h1-4,13,15H,(H2,11,12,16,17,18) RUQAZIFVMVELJS-UHFFFAOYSA-N 241956 5-(2-(4-Hydroxyphenyl)hydrazono)pyrimidine-2,4,6(1H,3H,5H)-trione (9) Ribosomal protein S6 kinase alpha-3 Homo sapiens 1.95e+3 7.4 25.00 C Curated from the literature by BindingDB 10.3109/14756366.2012.681651 10.7270/Q2DV1HT9 22545939 aid1803289 Xue, M; Xu, M; Lu, W; Huang, J; Li, H; Xu, Y; Liu, X; Zhao, Z East China University of Science and Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=241956 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=241956&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 6025709 341094209 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 422047 O=C1NC(=O)C(=NNc2ccc(cc2)N2CCOCC2)C(=O)N1 InChI=1S/C14H15N5O4/c20-12-11(13(21)16-14(22)15-12)18-17-9-1-3-10(4-2-9)19-5-7-23-8-6-19/h1-4,17H,5-8H2,(H2,15,16,20,21,22) SOIUEVGVHYNJNS-UHFFFAOYSA-N 241957 5-(2-(4-Morpholinophenyl)hydrazono)pyrimidine-2,4,6(1H,3H,5H)-trione (13) Ribosomal protein S6 kinase alpha-3 Homo sapiens 5.11e+3 7.4 25.00 C Curated from the literature by BindingDB 10.3109/14756366.2012.681651 10.7270/Q2DV1HT9 22545939 aid1803289 Xue, M; Xu, M; Lu, W; Huang, J; Li, H; Xu, Y; Liu, X; Zhao, Z East China University of Science and Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=241957 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=241957&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 71549678 341094210 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 422048 Oc1ccc(NN=C2C(=O)NC(=S)NC2=O)cc1 InChI=1S/C10H8N4O3S/c15-6-3-1-5(2-4-6)13-14-7-8(16)11-10(18)12-9(7)17/h1-4,13,15H,(H2,11,12,16,17,18) KRGHPEQKPRLYTJ-UHFFFAOYSA-N 241958 5-(2-(4-Hydroxyphenyl)hydrazono)-dihydro-2-thioxopyrimidine-4,6(1H,5H)-dione (14) Ribosomal protein S6 kinase alpha-3 Homo sapiens 2.19e+3 7.4 25.00 C Curated from the literature by BindingDB 10.3109/14756366.2012.681651 10.7270/Q2DV1HT9 22545939 aid1803289 Xue, M; Xu, M; Lu, W; Huang, J; Li, H; Xu, Y; Liu, X; Zhao, Z East China University of Science and Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=241958 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=241958&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 5723450 341094211 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 422049 O=C1NC(=S)NC(=O)C1=NNc1ccc(cc1)N1CCOCC1 InChI=1S/C14H15N5O3S/c20-12-11(13(21)16-14(23)15-12)18-17-9-1-3-10(4-2-9)19-5-7-22-8-6-19/h1-4,17H,5-8H2,(H2,15,16,20,21,23) MDZQPRHNZQFNEJ-UHFFFAOYSA-N 241959 5-(2-(4-Morpholinophenyl)hydrazono-dihydro-2-thioxopyrimidine-4,6(1H,5H)-dione (15) Ribosomal protein S6 kinase alpha-3 Homo sapiens 9.23e+3 7.4 25.00 C Curated from the literature by BindingDB 10.3109/14756366.2012.681651 10.7270/Q2DV1HT9 22545939 aid1803289 Xue, M; Xu, M; Lu, W; Huang, J; Li, H; Xu, Y; Liu, X; Zhao, Z East China University of Science and Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=241959 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=241959&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 71549816 341094212 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 422050 Cn1cc(C2=C(C(=O)NC2=O)c2cn(CCCSC(N)=N)c3ccccc23)c2ccccc12 InChI=1S/C25H23N5O2S/c1-29-13-17(15-7-2-4-9-19(15)29)21-22(24(32)28-23(21)31)18-14-30(11-6-12-33-25(26)27)20-10-5-3-8-16(18)20/h2-5,7-10,13-14H,6,11-12H2,1H3,(H3,26,27)(H,28,31,32) DSXXEELGXBCYNQ-UHFFFAOYSA-N 3175 3-[1-[3-(Amidinothio)propyl]-3-indolyl]-4-(1-methyl-3-indolyl)-1H-pyrrole-2,5-dione Methanesulfonate::BIM-9::Bisindolylmaleimide 11b::Bisindolylmaleimide IX::CHEMBL6291::ROCHE screening, 57::Ro 31-8220::Ro31-8220::[(3-{3-[4-(1-methyl-1H-indol-3-yl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl]-1H-indol-1-yl}propyl)sulfanyl]methanimidamide Ribosomal protein S6 kinase alpha-3 Homo sapiens 1e+1 7.4 25.00 C Curated from the literature by BindingDB 10.3109/14756366.2012.681651 10.7270/Q2DV1HT9 22545939 aid1803289 Xue, M; Xu, M; Lu, W; Huang, J; Li, H; Xu, Y; Liu, X; Zhao, Z East China University of Science and Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=3175 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=3175&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search DRN 2V7O,4OTH 5083 8032918 38912 CHEMBL6291 5259 ZINC03797930 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50073866 CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1 HKSZLNNOFSGOKW-FYTWVXJKSA-N 2579 (2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.1^{2,6}.0^{7,28}.0^{8,13}.0^{15,19}.0^{20,27}.0^{21,26}]nonacosa-8(13),9,11,14(28),15(19),20(27),21(26),22,24-nonaen-16-one::CHEMBL388978::Staurosporin, 4::Staurosporine::Staurosporine, 8::US9206188, Staurosporine::US9226923, Staurosporine Ribosomal protein S6 kinase alpha-3 Homo sapiens <0.50 ChEMBL 10.1016/j.ejmech.2011.07.001 10.7270/Q2NG4R1D 21794960 Andreani, A; Granaiola, M; Leoni, A; Locatelli, A; Morigi, R; Rambaldi, M; Varoli, L; Lannigan, D; Smith, J; Scudiero, D; Kondapaka, S; Shoemaker, RH Universit£ di Bologna http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=2579 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=2579&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search STO 1AQ1,1BYG,1E8Z,1NVR,1NXK,1OKY,1Q3D,1QPD,1QPJ,1SM2,1SNU,1STC,1U59,1WVY,1XBC,1XJD,1YHS,2BUJ,2CLQ,2DQ7,2GCD,2HW7,2ITQ,2ITU,2ITW,2NRY,2OIC 44259 8032349 15738 CHEMBL388978 346 C02079 ZINC03814434 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50073911 NC(=N)N\N=C/c1c(nc2sc(Br)cn12)-c1ccc(cc1)[N+]([O-])=O InChI=1S/C13H10BrN7O2S/c14-10-6-20-9(5-17-19-12(15)16)11(18-13(20)24-10)7-1-3-8(4-2-7)21(22)23/h1-6H,(H4,15,16,19)/b17-5- MICFEMGUNJSEGM-ZWSORDCHSA-N 50355550 CHEMBL1910608 Ribosomal protein S6 kinase alpha-3 Homo sapiens 1230 ChEMBL 10.1016/j.ejmech.2011.07.001 10.7270/Q2NG4R1D 21794960 Andreani, A; Granaiola, M; Leoni, A; Locatelli, A; Morigi, R; Rambaldi, M; Varoli, L; Lannigan, D; Smith, J; Scudiero, D; Kondapaka, S; Shoemaker, RH Universit£ di Bologna http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50355550 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50355550&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 57393795 136959574 CHEMBL1910608 ZINC73138040 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50074260 CSc1ccccc1Nc1nc(nc2c(NCC3CC3)ncnc12)N1CCN(CC1)C1CCNCC1 InChI=1S/C26H35N9S/c1-36-21-5-3-2-4-20(21)31-25-22-23(24(30-17-29-22)28-16-18-6-7-18)32-26(33-25)35-14-12-34(13-15-35)19-8-10-27-11-9-19/h2-5,17-19,27H,6-16H2,1H3,(H,28,29,30)(H,31,32,33) QEMQWMRZJAAQSZ-UHFFFAOYSA-N 50389320 CHEMBL2063926 Ribosomal protein S6 kinase alpha-3 Homo sapiens <10000 ChEMBL 10.1016/j.bmcl.2012.06.008 10.7270/Q21J9BV6 22795331 Maryanoff, BE; O'Neill, JC; McComsey, DF; Yabut, SC; Luci, DK; Gibbs, AC; Connelly, MA Janssen Pharmaceutical Companies of Johnson & Johnson L.L.C. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50389320 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50389320&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 66552478 160868403 CHEMBL2063926 ZINC84654286 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50109810 COc1cc(Nc2nc3cccc(-c4cccc5[nH]cnc45)c3o2)cc(OC)c1OC InChI=1S/C23H20N4O4/c1-28-18-10-13(11-19(29-2)22(18)30-3)26-23-27-17-9-5-7-15(21(17)31-23)14-6-4-8-16-20(14)25-12-24-16/h4-12H,1-3H3,(H,24,25)(H,26,27) ZWUCWBYYVLQXEP-UHFFFAOYSA-N 50021658 CHEMBL3298194 Ribosomal protein S6 kinase alpha-3 Homo sapiens 4.0 ChEMBL 10.1016/j.bmcl.2014.01.058 10.7270/Q2V126DB 24534486 Costales, A; Mathur, M; Ramurthy, S; Lan, J; Subramanian, S; Jain, R; Atallah, G; Setti, L; Lindvall, M; Appleton, BA; Ornelas, E; Feucht, P; Warne, B; Doyle, L; Basham, SE; Aronchik, I; Jefferson, AB; Shafer, CM Novartis Institutes for BioMedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50021658 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50021658&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 72771106 103932356 CHEMBL3298194 ZINC26822616 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50109811 COc1ccc(Nc2nc3cccc(-c4c(F)cccc4OC)c3o2)cc1O[C@H]1CCNC1 InChI=1S/C25H24FN3O4/c1-30-20-10-9-15(13-22(20)32-16-11-12-27-14-16)28-25-29-19-7-3-5-17(24(19)33-25)23-18(26)6-4-8-21(23)31-2/h3-10,13,16,27H,11-12,14H2,1-2H3,(H,28,29)/t16-/m0/s1 XECUHDNZTMADFD-INIZCTEOSA-N 50021659 CHEMBL3297951 Ribosomal protein S6 kinase alpha-3 Homo sapiens 10.0 ChEMBL 10.1016/j.bmcl.2014.01.058 10.7270/Q2V126DB 24534486 Costales, A; Mathur, M; Ramurthy, S; Lan, J; Subramanian, S; Jain, R; Atallah, G; Setti, L; Lindvall, M; Appleton, BA; Ornelas, E; Feucht, P; Warne, B; Doyle, L; Basham, SE; Aronchik, I; Jefferson, AB; Shafer, CM Novartis Institutes for BioMedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50021659 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50021659&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 90645197 103932357 CHEMBL3297951 ZINC26821494 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50109813 COc1cc(Nc2nc3cccc(-c4c(F)cccc4OC)c3o2)cc(OC)c1OC InChI=1S/C23H21FN2O5/c1-27-17-10-6-8-15(24)20(17)14-7-5-9-16-21(14)31-23(26-16)25-13-11-18(28-2)22(30-4)19(12-13)29-3/h5-12H,1-4H3,(H,25,26) ZDYXRELDNKSUBF-UHFFFAOYSA-N 50021660 CHEMBL3297945 Ribosomal protein S6 kinase alpha-3 Homo sapiens 20 ChEMBL 10.1016/j.bmcl.2014.01.058 10.7270/Q2V126DB 24534486 Costales, A; Mathur, M; Ramurthy, S; Lan, J; Subramanian, S; Jain, R; Atallah, G; Setti, L; Lindvall, M; Appleton, BA; Ornelas, E; Feucht, P; Warne, B; Doyle, L; Basham, SE; Aronchik, I; Jefferson, AB; Shafer, CM Novartis Institutes for BioMedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50021660 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50021660&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 2NR 4NW5 72771105 103932358 CHEMBL3297945 ZINC26822622 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50109814 COc1ccccc1-c1cccc2nc(Nc3cc(OC)c(OC)c(OC)c3)oc12 InChI=1S/C23H22N2O5/c1-26-18-11-6-5-8-15(18)16-9-7-10-17-21(16)30-23(25-17)24-14-12-19(27-2)22(29-4)20(13-14)28-3/h5-13H,1-4H3,(H,24,25) XRTXYXCNVWUOKB-UHFFFAOYSA-N 50021661 CHEMBL3298039 Ribosomal protein S6 kinase alpha-3 Homo sapiens 20 ChEMBL 10.1016/j.bmcl.2014.01.058 10.7270/Q2V126DB 24534486 Costales, A; Mathur, M; Ramurthy, S; Lan, J; Subramanian, S; Jain, R; Atallah, G; Setti, L; Lindvall, M; Appleton, BA; Ornelas, E; Feucht, P; Warne, B; Doyle, L; Basham, SE; Aronchik, I; Jefferson, AB; Shafer, CM Novartis Institutes for BioMedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50021661 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50021661&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 24800600 103932359 CHEMBL3298039 ZINC26833351 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50109815 COc1ccc(F)cc1-c1cccc2nc(Nc3cc(OC)c(OC)c(OC)c3)oc12 InChI=1S/C23H21FN2O5/c1-27-18-9-8-13(24)10-16(18)15-6-5-7-17-21(15)31-23(26-17)25-14-11-19(28-2)22(30-4)20(12-14)29-3/h5-12H,1-4H3,(H,25,26) ZQMGSEHFOOINGT-UHFFFAOYSA-N 50021662 CHEMBL3298045 Ribosomal protein S6 kinase alpha-3 Homo sapiens 40 ChEMBL 10.1016/j.bmcl.2014.01.058 10.7270/Q2V126DB 24534486 Costales, A; Mathur, M; Ramurthy, S; Lan, J; Subramanian, S; Jain, R; Atallah, G; Setti, L; Lindvall, M; Appleton, BA; Ornelas, E; Feucht, P; Warne, B; Doyle, L; Basham, SE; Aronchik, I; Jefferson, AB; Shafer, CM Novartis Institutes for BioMedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50021662 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50021662&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 90645198 103932360 CHEMBL3298045 ZINC26824581 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50109819 COc1cc(Nc2nc3cccc(-c4ccc(C)cc4OC)c3o2)cc(OC)c1OC InChI=1S/C24H24N2O5/c1-14-9-10-16(19(11-14)27-2)17-7-6-8-18-22(17)31-24(26-18)25-15-12-20(28-3)23(30-5)21(13-15)29-4/h6-13H,1-5H3,(H,25,26) HWXDZAYQHRBBQT-UHFFFAOYSA-N 50021663 CHEMBL3298046 Ribosomal protein S6 kinase alpha-3 Homo sapiens 40 ChEMBL 10.1016/j.bmcl.2014.01.058 10.7270/Q2V126DB 24534486 Costales, A; Mathur, M; Ramurthy, S; Lan, J; Subramanian, S; Jain, R; Atallah, G; Setti, L; Lindvall, M; Appleton, BA; Ornelas, E; Feucht, P; Warne, B; Doyle, L; Basham, SE; Aronchik, I; Jefferson, AB; Shafer, CM Novartis Institutes for BioMedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50021663 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50021663&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 90645199 103932361 CHEMBL3298046 ZINC26821183 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50109820 COc1cc(Nc2nc3cccc(-c4cccc5cn[nH]c45)c3o2)cc(OC)c1OC InChI=1S/C23H20N4O4/c1-28-18-10-14(11-19(29-2)22(18)30-3)25-23-26-17-9-5-8-16(21(17)31-23)15-7-4-6-13-12-24-27-20(13)15/h4-12H,1-3H3,(H,24,27)(H,25,26) LCVZRKFDNWPBET-UHFFFAOYSA-N 50021664 CHEMBL3298193 Ribosomal protein S6 kinase alpha-3 Homo sapiens 50 ChEMBL 10.1016/j.bmcl.2014.01.058 10.7270/Q2V126DB 24534486 Costales, A; Mathur, M; Ramurthy, S; Lan, J; Subramanian, S; Jain, R; Atallah, G; Setti, L; Lindvall, M; Appleton, BA; Ornelas, E; Feucht, P; Warne, B; Doyle, L; Basham, SE; Aronchik, I; Jefferson, AB; Shafer, CM Novartis Institutes for BioMedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50021664 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50021664&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 90645200 103932362 CHEMBL3298193 ZINC26850079 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50109821 COc1ccc(Nc2nc3cccc(-c4c(F)cccc4OC)c3o2)cc1OC InChI=1S/C22H19FN2O4/c1-26-17-11-10-13(12-19(17)28-3)24-22-25-16-8-4-6-14(21(16)29-22)20-15(23)7-5-9-18(20)27-2/h4-12H,1-3H3,(H,24,25) JSFCBYKENXVGRL-UHFFFAOYSA-N 50021665 CHEMBL3297948 Ribosomal protein S6 kinase alpha-3 Homo sapiens 70 ChEMBL 10.1016/j.bmcl.2014.01.058 10.7270/Q2V126DB 24534486 Costales, A; Mathur, M; Ramurthy, S; Lan, J; Subramanian, S; Jain, R; Atallah, G; Setti, L; Lindvall, M; Appleton, BA; Ornelas, E; Feucht, P; Warne, B; Doyle, L; Basham, SE; Aronchik, I; Jefferson, AB; Shafer, CM Novartis Institutes for BioMedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50021665 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50021665&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 90645201 103932363 CHEMBL3297948 ZINC26941912 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50109824 COc1cc(Nc2nc3cccc(-c4c(F)cccc4OC)c3o2)cc(OC)c1 InChI=1S/C22H19FN2O4/c1-26-14-10-13(11-15(12-14)27-2)24-22-25-18-8-4-6-16(21(18)29-22)20-17(23)7-5-9-19(20)28-3/h4-12H,1-3H3,(H,24,25) WGAAHZPAINDSDB-UHFFFAOYSA-N 50021666 CHEMBL3297947 Ribosomal protein S6 kinase alpha-3 Homo sapiens 210 ChEMBL 10.1016/j.bmcl.2014.01.058 10.7270/Q2V126DB 24534486 Costales, A; Mathur, M; Ramurthy, S; Lan, J; Subramanian, S; Jain, R; Atallah, G; Setti, L; Lindvall, M; Appleton, BA; Ornelas, E; Feucht, P; Warne, B; Doyle, L; Basham, SE; Aronchik, I; Jefferson, AB; Shafer, CM Novartis Institutes for BioMedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50021666 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50021666&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 90645202 103932364 CHEMBL3297947 ZINC26939433 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50109826 COc1ccc(Nc2nc3cccc(-c4c(F)cccc4OC)c3o2)cc1N InChI=1S/C21H18FN3O3/c1-26-17-10-9-12(11-15(17)23)24-21-25-16-7-3-5-13(20(16)28-21)19-14(22)6-4-8-18(19)27-2/h3-11H,23H2,1-2H3,(H,24,25) AATRJMCVLUZFSH-UHFFFAOYSA-N 50021667 CHEMBL3297950 Ribosomal protein S6 kinase alpha-3 Homo sapiens 220 ChEMBL 10.1016/j.bmcl.2014.01.058 10.7270/Q2V126DB 24534486 Costales, A; Mathur, M; Ramurthy, S; Lan, J; Subramanian, S; Jain, R; Atallah, G; Setti, L; Lindvall, M; Appleton, BA; Ornelas, E; Feucht, P; Warne, B; Doyle, L; Basham, SE; Aronchik, I; Jefferson, AB; Shafer, CM Novartis Institutes for BioMedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50021667 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50021667&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 90645203 103932365 CHEMBL3297950 ZINC26935651 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50109828 COc1cc(Nc2nc3cccc(-c4ccccc4F)c3o2)cc(OC)c1OC InChI=1S/C22H19FN2O4/c1-26-18-11-13(12-19(27-2)21(18)28-3)24-22-25-17-10-6-8-15(20(17)29-22)14-7-4-5-9-16(14)23/h4-12H,1-3H3,(H,24,25) FLSKMXCIDGMHDI-UHFFFAOYSA-N 50021668 CHEMBL3298040 Ribosomal protein S6 kinase alpha-3 Homo sapiens 220 ChEMBL 10.1016/j.bmcl.2014.01.058 10.7270/Q2V126DB 24534486 Costales, A; Mathur, M; Ramurthy, S; Lan, J; Subramanian, S; Jain, R; Atallah, G; Setti, L; Lindvall, M; Appleton, BA; Ornelas, E; Feucht, P; Warne, B; Doyle, L; Basham, SE; Aronchik, I; Jefferson, AB; Shafer, CM Novartis Institutes for BioMedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50021668 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50021668&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 90645204 103932366 CHEMBL3298040 ZINC26938258 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50109830 COc1cccc(F)c1-c1cccc2nc(Nc3cccc(c3)S(N)(=O)=O)oc12 InChI=1S/C20H16FN3O4S/c1-27-17-10-4-8-15(21)18(17)14-7-3-9-16-19(14)28-20(24-16)23-12-5-2-6-13(11-12)29(22,25)26/h2-11H,1H3,(H,23,24)(H2,22,25,26) OTMPGQSHVZZPJK-UHFFFAOYSA-N 50021669 CHEMBL3297949 Ribosomal protein S6 kinase alpha-3 Homo sapiens 340 ChEMBL 10.1016/j.bmcl.2014.01.058 10.7270/Q2V126DB 24534486 Costales, A; Mathur, M; Ramurthy, S; Lan, J; Subramanian, S; Jain, R; Atallah, G; Setti, L; Lindvall, M; Appleton, BA; Ornelas, E; Feucht, P; Warne, B; Doyle, L; Basham, SE; Aronchik, I; Jefferson, AB; Shafer, CM Novartis Institutes for BioMedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50021669 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50021669&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 90645205 103932367 CHEMBL3297949 ZINC26938324 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50109831 COc1cccc(Nc2nc3cccc(-c4c(F)cccc4OC)c3o2)c1 InChI=1S/C21H17FN2O3/c1-25-14-7-3-6-13(12-14)23-21-24-17-10-4-8-15(20(17)27-21)19-16(22)9-5-11-18(19)26-2/h3-12H,1-2H3,(H,23,24) ZNPMPVBLJKHNSN-UHFFFAOYSA-N 50021670 CHEMBL3297840 Ribosomal protein S6 kinase alpha-3 Homo sapiens 410 ChEMBL 10.1016/j.bmcl.2014.01.058 10.7270/Q2V126DB 24534486 Costales, A; Mathur, M; Ramurthy, S; Lan, J; Subramanian, S; Jain, R; Atallah, G; Setti, L; Lindvall, M; Appleton, BA; Ornelas, E; Feucht, P; Warne, B; Doyle, L; Basham, SE; Aronchik, I; Jefferson, AB; Shafer, CM Novartis Institutes for BioMedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50021670 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50021670&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 90645206 103932368 CHEMBL3297840 ZINC26939154 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50109835 CCOc1cccc(F)c1-c1cccc2nc(Nc3cc(OC)c(OC)c(OC)c3)oc12 InChI=1S/C24H23FN2O5/c1-5-31-18-11-7-9-16(25)21(18)15-8-6-10-17-22(15)32-24(27-17)26-14-12-19(28-2)23(30-4)20(13-14)29-3/h6-13H,5H2,1-4H3,(H,26,27) BFIIPSNMXRZJOY-UHFFFAOYSA-N 50021671 CHEMBL3298042 Ribosomal protein S6 kinase alpha-3 Homo sapiens 490 ChEMBL 10.1016/j.bmcl.2014.01.058 10.7270/Q2V126DB 24534486 Costales, A; Mathur, M; Ramurthy, S; Lan, J; Subramanian, S; Jain, R; Atallah, G; Setti, L; Lindvall, M; Appleton, BA; Ornelas, E; Feucht, P; Warne, B; Doyle, L; Basham, SE; Aronchik, I; Jefferson, AB; Shafer, CM Novartis Institutes for BioMedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50021671 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50021671&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 90645207 103932369 CHEMBL3298042 ZINC26851074 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50109839 COc1cc(Nc2nc3cccc(-c4nc(C)[nH]c4C)c3o2)cc(OC)c1OC InChI=1S/C21H22N4O4/c1-11-18(23-12(2)22-11)14-7-6-8-15-19(14)29-21(25-15)24-13-9-16(26-3)20(28-5)17(10-13)27-4/h6-10H,1-5H3,(H,22,23)(H,24,25) VVEBCQLECIQGHE-UHFFFAOYSA-N 50021672 CHEMBL3298192 Ribosomal protein S6 kinase alpha-3 Homo sapiens 560 ChEMBL 10.1016/j.bmcl.2014.01.058 10.7270/Q2V126DB 24534486 Costales, A; Mathur, M; Ramurthy, S; Lan, J; Subramanian, S; Jain, R; Atallah, G; Setti, L; Lindvall, M; Appleton, BA; Ornelas, E; Feucht, P; Warne, B; Doyle, L; Basham, SE; Aronchik, I; Jefferson, AB; Shafer, CM Novartis Institutes for BioMedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50021672 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50021672&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 90645208 103932370 CHEMBL3298192 ZINC26851052 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50109845 COc1cccc(F)c1-c1cccc2nc(NC3CCCCC3)oc12 InChI=1S/C20H21FN2O2/c1-24-17-12-6-10-15(21)18(17)14-9-5-11-16-19(14)25-20(23-16)22-13-7-3-2-4-8-13/h5-6,9-13H,2-4,7-8H2,1H3,(H,22,23) YMKXWFUPUHDFKL-UHFFFAOYSA-N 50021673 CHEMBL3297843 Ribosomal protein S6 kinase alpha-3 Homo sapiens 620 ChEMBL 10.1016/j.bmcl.2014.01.058 10.7270/Q2V126DB 24534486 Costales, A; Mathur, M; Ramurthy, S; Lan, J; Subramanian, S; Jain, R; Atallah, G; Setti, L; Lindvall, M; Appleton, BA; Ornelas, E; Feucht, P; Warne, B; Doyle, L; Basham, SE; Aronchik, I; Jefferson, AB; Shafer, CM Novartis Institutes for BioMedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50021673 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50021673&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 90645209 103932371 CHEMBL3297843 ZINC26937799 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50109848 COc1cccc(Nc2nc3cccc(-c4c(F)cccc4OC)c3o2)n1 InChI=1S/C20H16FN3O3/c1-25-15-9-4-7-13(21)18(15)12-6-3-8-14-19(12)27-20(22-14)24-16-10-5-11-17(23-16)26-2/h3-11H,1-2H3,(H,22,23,24) LRHLPBFCDHGQOT-UHFFFAOYSA-N 50021674 CHEMBL3297845 Ribosomal protein S6 kinase alpha-3 Homo sapiens 620 ChEMBL 10.1016/j.bmcl.2014.01.058 10.7270/Q2V126DB 24534486 Costales, A; Mathur, M; Ramurthy, S; Lan, J; Subramanian, S; Jain, R; Atallah, G; Setti, L; Lindvall, M; Appleton, BA; Ornelas, E; Feucht, P; Warne, B; Doyle, L; Basham, SE; Aronchik, I; Jefferson, AB; Shafer, CM Novartis Institutes for BioMedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50021674 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50021674&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 90645210 103932372 CHEMBL3297845 ZINC26935535 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50109851 CCOc1cccc(Nc2nc3cccc(-c4c(F)cccc4OC)c3o2)c1 InChI=1S/C22H19FN2O3/c1-3-27-15-8-4-7-14(13-15)24-22-25-18-11-5-9-16(21(18)28-22)20-17(23)10-6-12-19(20)26-2/h4-13H,3H2,1-2H3,(H,24,25) FMGZGKDQXIZQLF-UHFFFAOYSA-N 50021675 CHEMBL3297846 Ribosomal protein S6 kinase alpha-3 Homo sapiens 730 ChEMBL 10.1016/j.bmcl.2014.01.058 10.7270/Q2V126DB 24534486 Costales, A; Mathur, M; Ramurthy, S; Lan, J; Subramanian, S; Jain, R; Atallah, G; Setti, L; Lindvall, M; Appleton, BA; Ornelas, E; Feucht, P; Warne, B; Doyle, L; Basham, SE; Aronchik, I; Jefferson, AB; Shafer, CM Novartis Institutes for BioMedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50021675 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50021675&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 90645211 103932373 CHEMBL3297846 ZINC26935399 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50109852 COc1cc(Nc2nc3cccc(-c4cccc5[nH]cnc45)c3o2)cc(OC)c1OC InChI=1S/C23H20N4O4/c1-28-18-10-13(11-19(29-2)22(18)30-3)26-23-27-17-9-5-7-15(21(17)31-23)14-6-4-8-16-20(14)25-12-24-16/h4-12H,1-3H3,(H,24,25)(H,26,27) ZWUCWBYYVLQXEP-UHFFFAOYSA-N 50021658 CHEMBL3298194 Ribosomal protein S6 kinase alpha-3 Homo sapiens 800 ChEMBL 10.1016/j.bmcl.2014.01.058 10.7270/Q2V126DB 24534486 Costales, A; Mathur, M; Ramurthy, S; Lan, J; Subramanian, S; Jain, R; Atallah, G; Setti, L; Lindvall, M; Appleton, BA; Ornelas, E; Feucht, P; Warne, B; Doyle, L; Basham, SE; Aronchik, I; Jefferson, AB; Shafer, CM Novartis Institutes for BioMedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50021658 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50021658&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 72771106 103932356 CHEMBL3298194 ZINC26822616 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50109853 COc1cc(Nc2nc3cccc(-c4c(F)cccc4OC(C)C)c3o2)cc(OC)c1OC InChI=1S/C25H25FN2O5/c1-14(2)32-19-11-7-9-17(26)22(19)16-8-6-10-18-23(16)33-25(28-18)27-15-12-20(29-3)24(31-5)21(13-15)30-4/h6-14H,1-5H3,(H,27,28) KCVOKHWVSRPHJC-UHFFFAOYSA-N 50021676 CHEMBL3298043 Ribosomal protein S6 kinase alpha-3 Homo sapiens 970 ChEMBL 10.1016/j.bmcl.2014.01.058 10.7270/Q2V126DB 24534486 Costales, A; Mathur, M; Ramurthy, S; Lan, J; Subramanian, S; Jain, R; Atallah, G; Setti, L; Lindvall, M; Appleton, BA; Ornelas, E; Feucht, P; Warne, B; Doyle, L; Basham, SE; Aronchik, I; Jefferson, AB; Shafer, CM Novartis Institutes for BioMedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50021676 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50021676&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 90645212 103932374 CHEMBL3298043 ZINC26850465 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50109854 COc1cccc(F)c1-c1cccc2nc(Nc3ccccc3)oc12 InChI=1S/C20H15FN2O2/c1-24-17-12-6-10-15(21)18(17)14-9-5-11-16-19(14)25-20(23-16)22-13-7-3-2-4-8-13/h2-12H,1H3,(H,22,23) XDOILUADECHLAS-UHFFFAOYSA-N 50021677 CHEMBL3297842 Ribosomal protein S6 kinase alpha-3 Homo sapiens 1000 ChEMBL 10.1016/j.bmcl.2014.01.058 10.7270/Q2V126DB 24534486 Costales, A; Mathur, M; Ramurthy, S; Lan, J; Subramanian, S; Jain, R; Atallah, G; Setti, L; Lindvall, M; Appleton, BA; Ornelas, E; Feucht, P; Warne, B; Doyle, L; Basham, SE; Aronchik, I; Jefferson, AB; Shafer, CM Novartis Institutes for BioMedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50021677 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50021677&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 90645213 103932375 CHEMBL3297842 ZINC26944816 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50109855 COc1ccc(C)cc1-c1cccc2nc(Nc3cc(OC)c(OC)c(OC)c3)oc12 InChI=1S/C24H24N2O5/c1-14-9-10-19(27-2)17(11-14)16-7-6-8-18-22(16)31-24(26-18)25-15-12-20(28-3)23(30-5)21(13-15)29-4/h6-13H,1-5H3,(H,25,26) ITJWUDWPWZELPJ-UHFFFAOYSA-N 50021678 CHEMBL3298047 Ribosomal protein S6 kinase alpha-3 Homo sapiens 1100 ChEMBL 10.1016/j.bmcl.2014.01.058 10.7270/Q2V126DB 24534486 Costales, A; Mathur, M; Ramurthy, S; Lan, J; Subramanian, S; Jain, R; Atallah, G; Setti, L; Lindvall, M; Appleton, BA; Ornelas, E; Feucht, P; Warne, B; Doyle, L; Basham, SE; Aronchik, I; Jefferson, AB; Shafer, CM Novartis Institutes for BioMedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50021678 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50021678&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 90645214 103932376 CHEMBL3298047 ZINC26954590 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50109856 COc1cccc(OC)c1-c1cccc2nc(Nc3cc(OC)c(OC)c(OC)c3)oc12 InChI=1S/C24H24N2O6/c1-27-17-10-7-11-18(28-2)21(17)15-8-6-9-16-22(15)32-24(26-16)25-14-12-19(29-3)23(31-5)20(13-14)30-4/h6-13H,1-5H3,(H,25,26) QQAOLQXSAZVVHS-UHFFFAOYSA-N 50021679 CHEMBL3298044 Ribosomal protein S6 kinase alpha-3 Homo sapiens 1200 ChEMBL 10.1016/j.bmcl.2014.01.058 10.7270/Q2V126DB 24534486 Costales, A; Mathur, M; Ramurthy, S; Lan, J; Subramanian, S; Jain, R; Atallah, G; Setti, L; Lindvall, M; Appleton, BA; Ornelas, E; Feucht, P; Warne, B; Doyle, L; Basham, SE; Aronchik, I; Jefferson, AB; Shafer, CM Novartis Institutes for BioMedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50021679 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50021679&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 90645215 103932377 CHEMBL3298044 ZINC26851141 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50109857 COc1ccc(Nc2nc3cccc(-c4c(F)cccc4OC)c3o2)cc1 InChI=1S/C21H17FN2O3/c1-25-14-11-9-13(10-12-14)23-21-24-17-7-3-5-15(20(17)27-21)19-16(22)6-4-8-18(19)26-2/h3-12H,1-2H3,(H,23,24) YDNMXGCURWGSPK-UHFFFAOYSA-N 50021680 CHEMBL3297946 Ribosomal protein S6 kinase alpha-3 Homo sapiens 1400 ChEMBL 10.1016/j.bmcl.2014.01.058 10.7270/Q2V126DB 24534486 Costales, A; Mathur, M; Ramurthy, S; Lan, J; Subramanian, S; Jain, R; Atallah, G; Setti, L; Lindvall, M; Appleton, BA; Ornelas, E; Feucht, P; Warne, B; Doyle, L; Basham, SE; Aronchik, I; Jefferson, AB; Shafer, CM Novartis Institutes for BioMedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50021680 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50021680&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 90645216 103932378 CHEMBL3297946 ZINC26935819 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50109858 COc1cc(Nc2nc3cccc(-c4c(F)cccc4OC)c3o2)cc(OC)c1OC InChI=1S/C23H21FN2O5/c1-27-17-10-6-8-15(24)20(17)14-7-5-9-16-21(14)31-23(26-16)25-13-11-18(28-2)22(30-4)19(12-13)29-3/h5-12H,1-4H3,(H,25,26) ZDYXRELDNKSUBF-UHFFFAOYSA-N 50021660 CHEMBL3297945 Ribosomal protein S6 kinase alpha-3 Homo sapiens 2600 ChEMBL 10.1016/j.bmcl.2014.01.058 10.7270/Q2V126DB 24534486 Costales, A; Mathur, M; Ramurthy, S; Lan, J; Subramanian, S; Jain, R; Atallah, G; Setti, L; Lindvall, M; Appleton, BA; Ornelas, E; Feucht, P; Warne, B; Doyle, L; Basham, SE; Aronchik, I; Jefferson, AB; Shafer, CM Novartis Institutes for BioMedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50021660 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50021660&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 2NR 4NW5 72771105 103932358 CHEMBL3297945 ZINC26822622 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50109859 COc1cccc(F)c1-c1cccc2nc(N)oc12 InChI=1S/C14H11FN2O2/c1-18-11-7-3-5-9(15)12(11)8-4-2-6-10-13(8)19-14(16)17-10/h2-7H,1H3,(H2,16,17) ROWPQEPGMKPJNG-UHFFFAOYSA-N 50021681 CHEMBL3297841 Ribosomal protein S6 kinase alpha-3 Homo sapiens 2800 ChEMBL 10.1016/j.bmcl.2014.01.058 10.7270/Q2V126DB 24534486 Costales, A; Mathur, M; Ramurthy, S; Lan, J; Subramanian, S; Jain, R; Atallah, G; Setti, L; Lindvall, M; Appleton, BA; Ornelas, E; Feucht, P; Warne, B; Doyle, L; Basham, SE; Aronchik, I; Jefferson, AB; Shafer, CM Novartis Institutes for BioMedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50021681 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50021681&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 90645217 103932379 CHEMBL3297841 ZINC26851081 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50109860 COc1cccc(F)c1-c1cccc2nc(NC3CCOCC3)oc12 InChI=1S/C19H19FN2O3/c1-23-16-7-3-5-14(20)17(16)13-4-2-6-15-18(13)25-19(22-15)21-12-8-10-24-11-9-12/h2-7,12H,8-11H2,1H3,(H,21,22) KVPIMMONOVKADW-UHFFFAOYSA-N 50021682 CHEMBL3297844 Ribosomal protein S6 kinase alpha-3 Homo sapiens 3200 ChEMBL 10.1016/j.bmcl.2014.01.058 10.7270/Q2V126DB 24534486 Costales, A; Mathur, M; Ramurthy, S; Lan, J; Subramanian, S; Jain, R; Atallah, G; Setti, L; Lindvall, M; Appleton, BA; Ornelas, E; Feucht, P; Warne, B; Doyle, L; Basham, SE; Aronchik, I; Jefferson, AB; Shafer, CM Novartis Institutes for BioMedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50021682 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50021682&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 90645218 103932380 CHEMBL3297844 ZINC26850859 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50109861 COc1ccc(F)cc1-c1cccc2nc(Nc3cc(OC)c(OC)c(OC)c3)oc12 InChI=1S/C23H21FN2O5/c1-27-18-9-8-13(24)10-16(18)15-6-5-7-17-21(15)31-23(26-17)25-14-11-19(28-2)22(30-4)20(12-14)29-3/h5-12H,1-4H3,(H,25,26) ZQMGSEHFOOINGT-UHFFFAOYSA-N 50021662 CHEMBL3298045 Ribosomal protein S6 kinase alpha-3 Homo sapiens 3700 ChEMBL 10.1016/j.bmcl.2014.01.058 10.7270/Q2V126DB 24534486 Costales, A; Mathur, M; Ramurthy, S; Lan, J; Subramanian, S; Jain, R; Atallah, G; Setti, L; Lindvall, M; Appleton, BA; Ornelas, E; Feucht, P; Warne, B; Doyle, L; Basham, SE; Aronchik, I; Jefferson, AB; Shafer, CM Novartis Institutes for BioMedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50021662 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50021662&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 90645198 103932360 CHEMBL3298045 ZINC26824581 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50109862 COc1cc(Nc2nc3cccc(-c4ccccc4OC(F)(F)F)c3o2)cc(OC)c1OC InChI=1S/C23H19F3N2O5/c1-29-18-11-13(12-19(30-2)21(18)31-3)27-22-28-16-9-6-8-15(20(16)32-22)14-7-4-5-10-17(14)33-23(24,25)26/h4-12H,1-3H3,(H,27,28) KDQOOIHKBSSOBE-UHFFFAOYSA-N 50021683 CHEMBL3298041 Ribosomal protein S6 kinase alpha-3 Homo sapiens 4000 ChEMBL 10.1016/j.bmcl.2014.01.058 10.7270/Q2V126DB 24534486 Costales, A; Mathur, M; Ramurthy, S; Lan, J; Subramanian, S; Jain, R; Atallah, G; Setti, L; Lindvall, M; Appleton, BA; Ornelas, E; Feucht, P; Warne, B; Doyle, L; Basham, SE; Aronchik, I; Jefferson, AB; Shafer, CM Novartis Institutes for BioMedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50021683 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50021683&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 90645219 103932381 CHEMBL3298041 ZINC26939138 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50109863 COc1ccccc1-c1cccc2nc(Nc3cc(OC)c(OC)c(OC)c3)oc12 InChI=1S/C23H22N2O5/c1-26-18-11-6-5-8-15(18)16-9-7-10-17-21(16)30-23(25-17)24-14-12-19(27-2)22(29-4)20(13-14)28-3/h5-13H,1-4H3,(H,24,25) XRTXYXCNVWUOKB-UHFFFAOYSA-N 50021661 CHEMBL3298039 Ribosomal protein S6 kinase alpha-3 Homo sapiens 5700 ChEMBL 10.1016/j.bmcl.2014.01.058 10.7270/Q2V126DB 24534486 Costales, A; Mathur, M; Ramurthy, S; Lan, J; Subramanian, S; Jain, R; Atallah, G; Setti, L; Lindvall, M; Appleton, BA; Ornelas, E; Feucht, P; Warne, B; Doyle, L; Basham, SE; Aronchik, I; Jefferson, AB; Shafer, CM Novartis Institutes for BioMedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50021661 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50021661&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 24800600 103932359 CHEMBL3298039 ZINC26833351 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50109864 COc1cc(Nc2nc3cccc(-c4cccc5cn[nH]c45)c3o2)cc(OC)c1OC InChI=1S/C23H20N4O4/c1-28-18-10-14(11-19(29-2)22(18)30-3)25-23-26-17-9-5-8-16(21(17)31-23)15-7-4-6-13-12-24-27-20(13)15/h4-12H,1-3H3,(H,24,27)(H,25,26) LCVZRKFDNWPBET-UHFFFAOYSA-N 50021664 CHEMBL3298193 Ribosomal protein S6 kinase alpha-3 Homo sapiens 5700 ChEMBL 10.1016/j.bmcl.2014.01.058 10.7270/Q2V126DB 24534486 Costales, A; Mathur, M; Ramurthy, S; Lan, J; Subramanian, S; Jain, R; Atallah, G; Setti, L; Lindvall, M; Appleton, BA; Ornelas, E; Feucht, P; Warne, B; Doyle, L; Basham, SE; Aronchik, I; Jefferson, AB; Shafer, CM Novartis Institutes for BioMedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50021664 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50021664&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 90645200 103932362 CHEMBL3298193 ZINC26850079 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50109865 COc1ccc(Nc2nc3cccc(-c4c(F)cccc4OC)c3o2)cc1O[C@H]1CCNC1 InChI=1S/C25H24FN3O4/c1-30-20-10-9-15(13-22(20)32-16-11-12-27-14-16)28-25-29-19-7-3-5-17(24(19)33-25)23-18(26)6-4-8-21(23)31-2/h3-10,13,16,27H,11-12,14H2,1-2H3,(H,28,29)/t16-/m0/s1 XECUHDNZTMADFD-INIZCTEOSA-N 50021659 CHEMBL3297951 Ribosomal protein S6 kinase alpha-3 Homo sapiens 6300 ChEMBL 10.1016/j.bmcl.2014.01.058 10.7270/Q2V126DB 24534486 Costales, A; Mathur, M; Ramurthy, S; Lan, J; Subramanian, S; Jain, R; Atallah, G; Setti, L; Lindvall, M; Appleton, BA; Ornelas, E; Feucht, P; Warne, B; Doyle, L; Basham, SE; Aronchik, I; Jefferson, AB; Shafer, CM Novartis Institutes for BioMedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50021659 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50021659&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 90645197 103932357 CHEMBL3297951 ZINC26821494 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50109866 COc1ccc(Nc2nc3cccc(-c4c(F)cccc4OC)c3o2)cc1OC InChI=1S/C22H19FN2O4/c1-26-17-11-10-13(12-19(17)28-3)24-22-25-16-8-4-6-14(21(16)29-22)20-15(23)7-5-9-18(20)27-2/h4-12H,1-3H3,(H,24,25) JSFCBYKENXVGRL-UHFFFAOYSA-N 50021665 CHEMBL3297948 Ribosomal protein S6 kinase alpha-3 Homo sapiens 6500 ChEMBL 10.1016/j.bmcl.2014.01.058 10.7270/Q2V126DB 24534486 Costales, A; Mathur, M; Ramurthy, S; Lan, J; Subramanian, S; Jain, R; Atallah, G; Setti, L; Lindvall, M; Appleton, BA; Ornelas, E; Feucht, P; Warne, B; Doyle, L; Basham, SE; Aronchik, I; Jefferson, AB; Shafer, CM Novartis Institutes for BioMedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50021665 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50021665&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 90645201 103932363 CHEMBL3297948 ZINC26941912 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50109875 COc1cc(Nc2nc3cccc(-c4ccccc4-c4cn[nH]c4)c3o2)cc(OC)c1OC InChI=1S/C25H22N4O4/c1-30-21-11-16(12-22(31-2)24(21)32-3)28-25-29-20-10-6-9-19(23(20)33-25)18-8-5-4-7-17(18)15-13-26-27-14-15/h4-14H,1-3H3,(H,26,27)(H,28,29) AFCGAGZGPIDLNF-UHFFFAOYSA-N 50021684 CHEMBL3298191 Ribosomal protein S6 kinase alpha-3 Homo sapiens 9300 ChEMBL 10.1016/j.bmcl.2014.01.058 10.7270/Q2V126DB 24534486 Costales, A; Mathur, M; Ramurthy, S; Lan, J; Subramanian, S; Jain, R; Atallah, G; Setti, L; Lindvall, M; Appleton, BA; Ornelas, E; Feucht, P; Warne, B; Doyle, L; Basham, SE; Aronchik, I; Jefferson, AB; Shafer, CM Novartis Institutes for BioMedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50021684 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50021684&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 90645220 103932382 CHEMBL3298191 ZINC26950226 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50109877 COc1cc(Nc2nc3cccc(-c4ccc(C)cc4OC)c3o2)cc(OC)c1OC InChI=1S/C24H24N2O5/c1-14-9-10-16(19(11-14)27-2)17-7-6-8-18-22(17)31-24(26-18)25-15-12-20(28-3)23(30-5)21(13-15)29-4/h6-13H,1-5H3,(H,25,26) HWXDZAYQHRBBQT-UHFFFAOYSA-N 50021663 CHEMBL3298046 Ribosomal protein S6 kinase alpha-3 Homo sapiens 9700 ChEMBL 10.1016/j.bmcl.2014.01.058 10.7270/Q2V126DB 24534486 Costales, A; Mathur, M; Ramurthy, S; Lan, J; Subramanian, S; Jain, R; Atallah, G; Setti, L; Lindvall, M; Appleton, BA; Ornelas, E; Feucht, P; Warne, B; Doyle, L; Basham, SE; Aronchik, I; Jefferson, AB; Shafer, CM Novartis Institutes for BioMedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50021663 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50021663&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 90645199 103932361 CHEMBL3298046 ZINC26821183 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50109881 CCOc1cccc(F)c1-c1cccc2nc(Nc3cc(OC)c(OC)c(OC)c3)oc12 InChI=1S/C24H23FN2O5/c1-5-31-18-11-7-9-16(25)21(18)15-8-6-10-17-22(15)32-24(27-17)26-14-12-19(28-2)23(30-4)20(13-14)29-3/h6-13H,5H2,1-4H3,(H,26,27) BFIIPSNMXRZJOY-UHFFFAOYSA-N 50021671 CHEMBL3298042 Ribosomal protein S6 kinase alpha-3 Homo sapiens 10800 ChEMBL 10.1016/j.bmcl.2014.01.058 10.7270/Q2V126DB 24534486 Costales, A; Mathur, M; Ramurthy, S; Lan, J; Subramanian, S; Jain, R; Atallah, G; Setti, L; Lindvall, M; Appleton, BA; Ornelas, E; Feucht, P; Warne, B; Doyle, L; Basham, SE; Aronchik, I; Jefferson, AB; Shafer, CM Novartis Institutes for BioMedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50021671 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50021671&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 90645207 103932369 CHEMBL3298042 ZINC26851074 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50109882 COc1ccc(C)cc1-c1cccc2nc(Nc3cc(OC)c(OC)c(OC)c3)oc12 InChI=1S/C24H24N2O5/c1-14-9-10-19(27-2)17(11-14)16-7-6-8-18-22(16)31-24(26-18)25-15-12-20(28-3)23(30-5)21(13-15)29-4/h6-13H,1-5H3,(H,25,26) ITJWUDWPWZELPJ-UHFFFAOYSA-N 50021678 CHEMBL3298047 Ribosomal protein S6 kinase alpha-3 Homo sapiens 14500 ChEMBL 10.1016/j.bmcl.2014.01.058 10.7270/Q2V126DB 24534486 Costales, A; Mathur, M; Ramurthy, S; Lan, J; Subramanian, S; Jain, R; Atallah, G; Setti, L; Lindvall, M; Appleton, BA; Ornelas, E; Feucht, P; Warne, B; Doyle, L; Basham, SE; Aronchik, I; Jefferson, AB; Shafer, CM Novartis Institutes for BioMedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50021678 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50021678&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 90645214 103932376 CHEMBL3298047 ZINC26954590 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50109893 COc1cccc(Nc2nc3cccc(-c4c(F)cccc4OC)c3o2)c1 InChI=1S/C21H17FN2O3/c1-25-14-7-3-6-13(12-14)23-21-24-17-10-4-8-15(20(17)27-21)19-16(22)9-5-11-18(19)26-2/h3-12H,1-2H3,(H,23,24) ZNPMPVBLJKHNSN-UHFFFAOYSA-N 50021670 CHEMBL3297840 Ribosomal protein S6 kinase alpha-3 Homo sapiens 15400 ChEMBL 10.1016/j.bmcl.2014.01.058 10.7270/Q2V126DB 24534486 Costales, A; Mathur, M; Ramurthy, S; Lan, J; Subramanian, S; Jain, R; Atallah, G; Setti, L; Lindvall, M; Appleton, BA; Ornelas, E; Feucht, P; Warne, B; Doyle, L; Basham, SE; Aronchik, I; Jefferson, AB; Shafer, CM Novartis Institutes for BioMedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50021670 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50021670&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 90645206 103932368 CHEMBL3297840 ZINC26939154 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50109904 COc1cc(Nc2nc3cccc(-c4c(F)cccc4OC)c3o2)cc(OC)c1 InChI=1S/C22H19FN2O4/c1-26-14-10-13(11-15(12-14)27-2)24-22-25-18-8-4-6-16(21(18)29-22)20-17(23)7-5-9-19(20)28-3/h4-12H,1-3H3,(H,24,25) WGAAHZPAINDSDB-UHFFFAOYSA-N 50021666 CHEMBL3297947 Ribosomal protein S6 kinase alpha-3 Homo sapiens 17200 ChEMBL 10.1016/j.bmcl.2014.01.058 10.7270/Q2V126DB 24534486 Costales, A; Mathur, M; Ramurthy, S; Lan, J; Subramanian, S; Jain, R; Atallah, G; Setti, L; Lindvall, M; Appleton, BA; Ornelas, E; Feucht, P; Warne, B; Doyle, L; Basham, SE; Aronchik, I; Jefferson, AB; Shafer, CM Novartis Institutes for BioMedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50021666 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50021666&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 90645202 103932364 CHEMBL3297947 ZINC26939433 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50109907 COc1cc(Nc2nc3cccc(-c4ccccc4F)c3o2)cc(OC)c1OC InChI=1S/C22H19FN2O4/c1-26-18-11-13(12-19(27-2)21(18)28-3)24-22-25-17-10-6-8-15(20(17)29-22)14-7-4-5-9-16(14)23/h4-12H,1-3H3,(H,24,25) FLSKMXCIDGMHDI-UHFFFAOYSA-N 50021668 CHEMBL3298040 Ribosomal protein S6 kinase alpha-3 Homo sapiens 18000 ChEMBL 10.1016/j.bmcl.2014.01.058 10.7270/Q2V126DB 24534486 Costales, A; Mathur, M; Ramurthy, S; Lan, J; Subramanian, S; Jain, R; Atallah, G; Setti, L; Lindvall, M; Appleton, BA; Ornelas, E; Feucht, P; Warne, B; Doyle, L; Basham, SE; Aronchik, I; Jefferson, AB; Shafer, CM Novartis Institutes for BioMedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50021668 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50021668&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 90645204 103932366 CHEMBL3298040 ZINC26938258 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50109909 COc1cc(Nc2nc3cccc(-c4nc(C)[nH]c4C)c3o2)cc(OC)c1OC InChI=1S/C21H22N4O4/c1-11-18(23-12(2)22-11)14-7-6-8-15-19(14)29-21(25-15)24-13-9-16(26-3)20(28-5)17(10-13)27-4/h6-10H,1-5H3,(H,22,23)(H,24,25) VVEBCQLECIQGHE-UHFFFAOYSA-N 50021672 CHEMBL3298192 Ribosomal protein S6 kinase alpha-3 Homo sapiens 19800 ChEMBL 10.1016/j.bmcl.2014.01.058 10.7270/Q2V126DB 24534486 Costales, A; Mathur, M; Ramurthy, S; Lan, J; Subramanian, S; Jain, R; Atallah, G; Setti, L; Lindvall, M; Appleton, BA; Ornelas, E; Feucht, P; Warne, B; Doyle, L; Basham, SE; Aronchik, I; Jefferson, AB; Shafer, CM Novartis Institutes for BioMedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50021672 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50021672&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 90645208 103932370 CHEMBL3298192 ZINC26851052 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50109921 COc1cccc(F)c1-c1cccc2nc(N)oc12 InChI=1S/C14H11FN2O2/c1-18-11-7-3-5-9(15)12(11)8-4-2-6-10-13(8)19-14(16)17-10/h2-7H,1H3,(H2,16,17) ROWPQEPGMKPJNG-UHFFFAOYSA-N 50021681 CHEMBL3297841 Ribosomal protein S6 kinase alpha-3 Homo sapiens >20000 ChEMBL 10.1016/j.bmcl.2014.01.058 10.7270/Q2V126DB 24534486 Costales, A; Mathur, M; Ramurthy, S; Lan, J; Subramanian, S; Jain, R; Atallah, G; Setti, L; Lindvall, M; Appleton, BA; Ornelas, E; Feucht, P; Warne, B; Doyle, L; Basham, SE; Aronchik, I; Jefferson, AB; Shafer, CM Novartis Institutes for BioMedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50021681 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50021681&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 90645217 103932379 CHEMBL3297841 ZINC26851081 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50109922 COc1cccc(F)c1-c1cccc2nc(Nc3ccccc3)oc12 InChI=1S/C20H15FN2O2/c1-24-17-12-6-10-15(21)18(17)14-9-5-11-16-19(14)25-20(23-16)22-13-7-3-2-4-8-13/h2-12H,1H3,(H,22,23) XDOILUADECHLAS-UHFFFAOYSA-N 50021677 CHEMBL3297842 Ribosomal protein S6 kinase alpha-3 Homo sapiens >20000 ChEMBL 10.1016/j.bmcl.2014.01.058 10.7270/Q2V126DB 24534486 Costales, A; Mathur, M; Ramurthy, S; Lan, J; Subramanian, S; Jain, R; Atallah, G; Setti, L; Lindvall, M; Appleton, BA; Ornelas, E; Feucht, P; Warne, B; Doyle, L; Basham, SE; Aronchik, I; Jefferson, AB; Shafer, CM Novartis Institutes for BioMedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50021677 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50021677&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 90645213 103932375 CHEMBL3297842 ZINC26944816 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50109935 COc1cccc(F)c1-c1cccc2nc(NC3CCCCC3)oc12 InChI=1S/C20H21FN2O2/c1-24-17-12-6-10-15(21)18(17)14-9-5-11-16-19(14)25-20(23-16)22-13-7-3-2-4-8-13/h5-6,9-13H,2-4,7-8H2,1H3,(H,22,23) YMKXWFUPUHDFKL-UHFFFAOYSA-N 50021673 CHEMBL3297843 Ribosomal protein S6 kinase alpha-3 Homo sapiens >20000 ChEMBL 10.1016/j.bmcl.2014.01.058 10.7270/Q2V126DB 24534486 Costales, A; Mathur, M; Ramurthy, S; Lan, J; Subramanian, S; Jain, R; Atallah, G; Setti, L; Lindvall, M; Appleton, BA; Ornelas, E; Feucht, P; Warne, B; Doyle, L; Basham, SE; Aronchik, I; Jefferson, AB; Shafer, CM Novartis Institutes for BioMedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50021673 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50021673&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 90645209 103932371 CHEMBL3297843 ZINC26937799 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50109938 COc1cccc(F)c1-c1cccc2nc(NC3CCOCC3)oc12 InChI=1S/C19H19FN2O3/c1-23-16-7-3-5-14(20)17(16)13-4-2-6-15-18(13)25-19(22-15)21-12-8-10-24-11-9-12/h2-7,12H,8-11H2,1H3,(H,21,22) KVPIMMONOVKADW-UHFFFAOYSA-N 50021682 CHEMBL3297844 Ribosomal protein S6 kinase alpha-3 Homo sapiens >20000 ChEMBL 10.1016/j.bmcl.2014.01.058 10.7270/Q2V126DB 24534486 Costales, A; Mathur, M; Ramurthy, S; Lan, J; Subramanian, S; Jain, R; Atallah, G; Setti, L; Lindvall, M; Appleton, BA; Ornelas, E; Feucht, P; Warne, B; Doyle, L; Basham, SE; Aronchik, I; Jefferson, AB; Shafer, CM Novartis Institutes for BioMedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50021682 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50021682&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 90645218 103932380 CHEMBL3297844 ZINC26850859 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50109942 COc1cccc(Nc2nc3cccc(-c4c(F)cccc4OC)c3o2)n1 InChI=1S/C20H16FN3O3/c1-25-15-9-4-7-13(21)18(15)12-6-3-8-14-19(12)27-20(22-14)24-16-10-5-11-17(23-16)26-2/h3-11H,1-2H3,(H,22,23,24) LRHLPBFCDHGQOT-UHFFFAOYSA-N 50021674 CHEMBL3297845 Ribosomal protein S6 kinase alpha-3 Homo sapiens >20000 ChEMBL 10.1016/j.bmcl.2014.01.058 10.7270/Q2V126DB 24534486 Costales, A; Mathur, M; Ramurthy, S; Lan, J; Subramanian, S; Jain, R; Atallah, G; Setti, L; Lindvall, M; Appleton, BA; Ornelas, E; Feucht, P; Warne, B; Doyle, L; Basham, SE; Aronchik, I; Jefferson, AB; Shafer, CM Novartis Institutes for BioMedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50021674 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50021674&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 90645210 103932372 CHEMBL3297845 ZINC26935535 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50109943 CCOc1cccc(Nc2nc3cccc(-c4c(F)cccc4OC)c3o2)c1 InChI=1S/C22H19FN2O3/c1-3-27-15-8-4-7-14(13-15)24-22-25-18-11-5-9-16(21(18)28-22)20-17(23)10-6-12-19(20)26-2/h4-13H,3H2,1-2H3,(H,24,25) FMGZGKDQXIZQLF-UHFFFAOYSA-N 50021675 CHEMBL3297846 Ribosomal protein S6 kinase alpha-3 Homo sapiens >20000 ChEMBL 10.1016/j.bmcl.2014.01.058 10.7270/Q2V126DB 24534486 Costales, A; Mathur, M; Ramurthy, S; Lan, J; Subramanian, S; Jain, R; Atallah, G; Setti, L; Lindvall, M; Appleton, BA; Ornelas, E; Feucht, P; Warne, B; Doyle, L; Basham, SE; Aronchik, I; Jefferson, AB; Shafer, CM Novartis Institutes for BioMedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50021675 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50021675&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 90645211 103932373 CHEMBL3297846 ZINC26935399 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50109952 COc1ccc(Nc2nc3cccc(-c4c(F)cccc4OC)c3o2)cc1 InChI=1S/C21H17FN2O3/c1-25-14-11-9-13(10-12-14)23-21-24-17-7-3-5-15(20(17)27-21)19-16(22)6-4-8-18(19)26-2/h3-12H,1-2H3,(H,23,24) YDNMXGCURWGSPK-UHFFFAOYSA-N 50021680 CHEMBL3297946 Ribosomal protein S6 kinase alpha-3 Homo sapiens >20000 ChEMBL 10.1016/j.bmcl.2014.01.058 10.7270/Q2V126DB 24534486 Costales, A; Mathur, M; Ramurthy, S; Lan, J; Subramanian, S; Jain, R; Atallah, G; Setti, L; Lindvall, M; Appleton, BA; Ornelas, E; Feucht, P; Warne, B; Doyle, L; Basham, SE; Aronchik, I; Jefferson, AB; Shafer, CM Novartis Institutes for BioMedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50021680 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50021680&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 90645216 103932378 CHEMBL3297946 ZINC26935819 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50109953 COc1cccc(F)c1-c1cccc2nc(Nc3cccc(c3)S(N)(=O)=O)oc12 InChI=1S/C20H16FN3O4S/c1-27-17-10-4-8-15(21)18(17)14-7-3-9-16-19(14)28-20(24-16)23-12-5-2-6-13(11-12)29(22,25)26/h2-11H,1H3,(H,23,24)(H2,22,25,26) OTMPGQSHVZZPJK-UHFFFAOYSA-N 50021669 CHEMBL3297949 Ribosomal protein S6 kinase alpha-3 Homo sapiens >20000 ChEMBL 10.1016/j.bmcl.2014.01.058 10.7270/Q2V126DB 24534486 Costales, A; Mathur, M; Ramurthy, S; Lan, J; Subramanian, S; Jain, R; Atallah, G; Setti, L; Lindvall, M; Appleton, BA; Ornelas, E; Feucht, P; Warne, B; Doyle, L; Basham, SE; Aronchik, I; Jefferson, AB; Shafer, CM Novartis Institutes for BioMedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50021669 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50021669&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 90645205 103932367 CHEMBL3297949 ZINC26938324 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50109964 COc1ccc(Nc2nc3cccc(-c4c(F)cccc4OC)c3o2)cc1N InChI=1S/C21H18FN3O3/c1-26-17-10-9-12(11-15(17)23)24-21-25-16-7-3-5-13(20(16)28-21)19-14(22)6-4-8-18(19)27-2/h3-11H,23H2,1-2H3,(H,24,25) AATRJMCVLUZFSH-UHFFFAOYSA-N 50021667 CHEMBL3297950 Ribosomal protein S6 kinase alpha-3 Homo sapiens >20000 ChEMBL 10.1016/j.bmcl.2014.01.058 10.7270/Q2V126DB 24534486 Costales, A; Mathur, M; Ramurthy, S; Lan, J; Subramanian, S; Jain, R; Atallah, G; Setti, L; Lindvall, M; Appleton, BA; Ornelas, E; Feucht, P; Warne, B; Doyle, L; Basham, SE; Aronchik, I; Jefferson, AB; Shafer, CM Novartis Institutes for BioMedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50021667 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50021667&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 90645203 103932365 CHEMBL3297950 ZINC26935651 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50109965 COc1cc(Nc2nc3cccc(-c4ccccc4OC(F)(F)F)c3o2)cc(OC)c1OC InChI=1S/C23H19F3N2O5/c1-29-18-11-13(12-19(30-2)21(18)31-3)27-22-28-16-9-6-8-15(20(16)32-22)14-7-4-5-10-17(14)33-23(24,25)26/h4-12H,1-3H3,(H,27,28) KDQOOIHKBSSOBE-UHFFFAOYSA-N 50021683 CHEMBL3298041 Ribosomal protein S6 kinase alpha-3 Homo sapiens >20000 ChEMBL 10.1016/j.bmcl.2014.01.058 10.7270/Q2V126DB 24534486 Costales, A; Mathur, M; Ramurthy, S; Lan, J; Subramanian, S; Jain, R; Atallah, G; Setti, L; Lindvall, M; Appleton, BA; Ornelas, E; Feucht, P; Warne, B; Doyle, L; Basham, SE; Aronchik, I; Jefferson, AB; Shafer, CM Novartis Institutes for BioMedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50021683 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50021683&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 90645219 103932381 CHEMBL3298041 ZINC26939138 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50109972 COc1cc(Nc2nc3cccc(-c4c(F)cccc4OC(C)C)c3o2)cc(OC)c1OC InChI=1S/C25H25FN2O5/c1-14(2)32-19-11-7-9-17(26)22(19)16-8-6-10-18-23(16)33-25(28-18)27-15-12-20(29-3)24(31-5)21(13-15)30-4/h6-14H,1-5H3,(H,27,28) KCVOKHWVSRPHJC-UHFFFAOYSA-N 50021676 CHEMBL3298043 Ribosomal protein S6 kinase alpha-3 Homo sapiens >20000 ChEMBL 10.1016/j.bmcl.2014.01.058 10.7270/Q2V126DB 24534486 Costales, A; Mathur, M; Ramurthy, S; Lan, J; Subramanian, S; Jain, R; Atallah, G; Setti, L; Lindvall, M; Appleton, BA; Ornelas, E; Feucht, P; Warne, B; Doyle, L; Basham, SE; Aronchik, I; Jefferson, AB; Shafer, CM Novartis Institutes for BioMedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50021676 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50021676&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 90645212 103932374 CHEMBL3298043 ZINC26850465 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50109978 COc1cccc(OC)c1-c1cccc2nc(Nc3cc(OC)c(OC)c(OC)c3)oc12 InChI=1S/C24H24N2O6/c1-27-17-10-7-11-18(28-2)21(17)15-8-6-9-16-22(15)32-24(26-16)25-14-12-19(29-3)23(31-5)20(13-14)30-4/h6-13H,1-5H3,(H,25,26) QQAOLQXSAZVVHS-UHFFFAOYSA-N 50021679 CHEMBL3298044 Ribosomal protein S6 kinase alpha-3 Homo sapiens >20000 ChEMBL 10.1016/j.bmcl.2014.01.058 10.7270/Q2V126DB 24534486 Costales, A; Mathur, M; Ramurthy, S; Lan, J; Subramanian, S; Jain, R; Atallah, G; Setti, L; Lindvall, M; Appleton, BA; Ornelas, E; Feucht, P; Warne, B; Doyle, L; Basham, SE; Aronchik, I; Jefferson, AB; Shafer, CM Novartis Institutes for BioMedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50021679 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50021679&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 90645215 103932377 CHEMBL3298044 ZINC26851141 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50109983 COc1cc(Nc2nc3cccc(-c4ccccc4-c4cn[nH]c4)c3o2)cc(OC)c1OC InChI=1S/C25H22N4O4/c1-30-21-11-16(12-22(31-2)24(21)32-3)28-25-29-20-10-6-9-19(23(20)33-25)18-8-5-4-7-17(18)15-13-26-27-14-15/h4-14H,1-3H3,(H,26,27)(H,28,29) AFCGAGZGPIDLNF-UHFFFAOYSA-N 50021684 CHEMBL3298191 Ribosomal protein S6 kinase alpha-3 Homo sapiens >20000 ChEMBL 10.1016/j.bmcl.2014.01.058 10.7270/Q2V126DB 24534486 Costales, A; Mathur, M; Ramurthy, S; Lan, J; Subramanian, S; Jain, R; Atallah, G; Setti, L; Lindvall, M; Appleton, BA; Ornelas, E; Feucht, P; Warne, B; Doyle, L; Basham, SE; Aronchik, I; Jefferson, AB; Shafer, CM Novartis Institutes for BioMedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50021684 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50021684&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 90645220 103932382 CHEMBL3298191 ZINC26950226 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50126358 CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1 HKSZLNNOFSGOKW-FYTWVXJKSA-N 2579 (2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.1^{2,6}.0^{7,28}.0^{8,13}.0^{15,19}.0^{20,27}.0^{21,26}]nonacosa-8(13),9,11,14(28),15(19),20(27),21(26),22,24-nonaen-16-one::CHEMBL388978::Staurosporin, 4::Staurosporine::Staurosporine, 8::US9206188, Staurosporine::US9226923, Staurosporine Ribosomal protein S6 kinase alpha-3 Homo sapiens 60 ChEMBL 10.1038/nbt1068 10.7270/Q2V69J3T 15711537 Fabian, MA; Biggs, WH; Treiber, DK; Atteridge, CE; Azimioara, MD; Benedetti, MG; Carter, TA; Ciceri, P; Edeen, PT; Floyd, M; Ford, JM; Galvin, M; Gerlach, JL; Grotzfeld, RM; Herrgard, S; Insko, DE; Insko, MA; Lai, AG; Lelias, JM; Mehta, SA; Milanov, ZV; Velasco, AM; Wodicka, LM; Patel, HK; Zarrinkar, PP; Lockhart, DJ Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=2579 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=2579&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search STO 1AQ1,1BYG,1E8Z,1NVR,1NXK,1OKY,1Q3D,1QPD,1QPJ,1SM2,1SNU,1STC,1U59,1WVY,1XBC,1XJD,1YHS,2BUJ,2CLQ,2DQ7,2GCD,2HW7,2ITQ,2ITU,2ITW,2NRY,2OIC 44259 8032349 15738 CHEMBL388978 346 C02079 ZINC03814434 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50165469 C[C@]12O[C@H](C[C@]1(O)CO)n1c3ccccc3c3c4C(=O)NCc4c4c5ccccc5n2c4c13 InChI=1S/C26H21N3O4/c1-25-26(32,12-30)10-18(33-25)28-16-8-4-2-6-13(16)20-21-15(11-27-24(21)31)19-14-7-3-5-9-17(14)29(25)23(19)22(20)28/h2-9,18,30,32H,10-12H2,1H3,(H,27,31)/t18-,25+,26+/m1/s1 UIARLYUEJFELEN-LROUJFHJSA-N 50308060 16-hydroxy-16-(hydroxymethyl)-15-methyl-28-oxa-4,14,19-triazaoctacyclo[12.11.2.1^{15,18}.0^{2,6}.0^{7,27}.0^{8,13}.0^{19,26}.0^{20,25}]octacosa-1(26),2(6),7(27),8(13),9,11,20(25),21,23-nonaen-3-one::CEP-701::CHEMBL603469::US11370779, Compound CEP-701 Ribosomal protein S6 kinase alpha-3 Homo sapiens 1300 ChEMBL 10.1182/blood-2009-05-222034 10.7270/Q2PN95V2 19654408 Zarrinkar, PP; Gunawardane, RN; Cramer, MD; Gardner, MF; Brigham, D; Belli, B; Karaman, MW; Pratz, KW; Pallares, G; Chao, Q; Sprankle, KG; Patel, HK; Levis, M; Armstrong, RC; James, J; Bhagwat, SS Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50308060 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50308060&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 2V9 5WNJ,4OTG 126565 104162421 CHEMBL603469 5672 ZINC03781738 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50166496 CO[C@@H]1[C@@H](C[C@H]2O[C@]1(C)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13)N(C)C(=O)c1ccccc1 InChI=1S/C35H30N4O4/c1-35-32(42-3)25(37(2)34(41)19-11-5-4-6-12-19)17-26(43-35)38-23-15-9-7-13-20(23)28-29-22(18-36-33(29)40)27-21-14-8-10-16-24(21)39(35)31(27)30(28)38/h4-16,25-26,32H,17-18H2,1-3H3,(H,36,40)/t25-,26-,32-,35+/m1/s1 BMGQWWVMWDBQGC-IIFHNQTCSA-N 50326053 CHEMBL608533::PKC-412 Ribosomal protein S6 kinase alpha-3 Homo sapiens >10000 ChEMBL 10.1182/blood-2009-05-222034 10.7270/Q2PN95V2 19654408 Zarrinkar, PP; Gunawardane, RN; Cramer, MD; Gardner, MF; Brigham, D; Belli, B; Karaman, MW; Pratz, KW; Pallares, G; Chao, Q; Sprankle, KG; Patel, HK; Levis, M; Armstrong, RC; James, J; Bhagwat, SS Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50326053 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50326053&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 2K2 4NCT 9829523 123105168 63452 CHEMBL608533 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50189268 COC(=O)c1ccc2\C(=C(\Nc3ccc(cc3)N(C)C(=O)CN3CCN(C)CC3)c3ccccc3)C(=O)Nc2c1 InChI=1S/C31H33N5O4/c1-34-15-17-36(18-16-34)20-27(37)35(2)24-12-10-23(11-13-24)32-29(21-7-5-4-6-8-21)28-25-14-9-22(31(39)40-3)19-26(25)33-30(28)38/h4-14,19,32H,15-18,20H2,1-3H3,(H,33,38)/b29-28- XZXHXSATPCNXJR-ZIADKAODSA-N 50026612 BIBF-1120::Nintedanib::US10981896, Compound Nintedanib::US11046672, Nintedanib::US11208381, Nintedanib::Vargatef Ribosomal protein S6 kinase alpha-3 Homo sapiens 65 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50026612 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50026612&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search XIN 5MAF,6NEC,3C7Q,5TE0 9809715 277286638 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50181724 CO[C@@H]1[C@@H](C[C@H]2O[C@]1(C)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13)N(C)C(=O)c1ccccc1 InChI=1S/C35H30N4O4/c1-35-32(42-3)25(37(2)34(41)19-11-5-4-6-12-19)17-26(43-35)38-23-15-9-7-13-20(23)28-29-22(18-36-33(29)40)27-21-14-8-10-16-24(21)39(35)31(27)30(28)38/h4-16,25-26,32H,17-18H2,1-3H3,(H,36,40)/t25-,26-,32-,35+/m1/s1 BMGQWWVMWDBQGC-IIFHNQTCSA-N 50326053 CHEMBL608533::PKC-412 Ribosomal protein S6 kinase alpha-3 Homo sapiens 740 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50326053 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50326053&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 2K2 4NCT 9829523 123105168 63452 CHEMBL608533 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50180350 CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1 HKSZLNNOFSGOKW-FYTWVXJKSA-N 2579 (2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.1^{2,6}.0^{7,28}.0^{8,13}.0^{15,19}.0^{20,27}.0^{21,26}]nonacosa-8(13),9,11,14(28),15(19),20(27),21(26),22,24-nonaen-16-one::CHEMBL388978::Staurosporin, 4::Staurosporine::Staurosporine, 8::US9206188, Staurosporine::US9226923, Staurosporine Ribosomal protein S6 kinase alpha-3 Homo sapiens 69 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=2579 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=2579&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search STO 1AQ1,1BYG,1E8Z,1NVR,1NXK,1OKY,1Q3D,1QPD,1QPJ,1SM2,1SNU,1STC,1U59,1WVY,1XBC,1XJD,1YHS,2BUJ,2CLQ,2DQ7,2GCD,2HW7,2ITQ,2ITU,2ITW,2NRY,2OIC 44259 8032349 15738 CHEMBL388978 346 C02079 ZINC03814434 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50195704 C[C@]12O[C@H](C[C@]1(O)CO)n1c3ccccc3c3c4C(=O)NCc4c4c5ccccc5n2c4c13 InChI=1S/C26H21N3O4/c1-25-26(32,12-30)10-18(33-25)28-16-8-4-2-6-13(16)20-21-15(11-27-24(21)31)19-14-7-3-5-9-17(14)29(25)23(19)22(20)28/h2-9,18,30,32H,10-12H2,1H3,(H,27,31)/t18-,25+,26+/m1/s1 UIARLYUEJFELEN-LROUJFHJSA-N 50308060 16-hydroxy-16-(hydroxymethyl)-15-methyl-28-oxa-4,14,19-triazaoctacyclo[12.11.2.1^{15,18}.0^{2,6}.0^{7,27}.0^{8,13}.0^{19,26}.0^{20,25}]octacosa-1(26),2(6),7(27),8(13),9,11,20(25),21,23-nonaen-3-one::CEP-701::CHEMBL603469::US11370779, Compound CEP-701 Ribosomal protein S6 kinase alpha-3 Homo sapiens 290 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50308060 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50308060&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 2V9 5WNJ,4OTG 126565 104162421 CHEMBL603469 5672 ZINC03781738 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50199097 CC(C)n1c(NC(=O)c2ccc3cc4C(=O)NCCCn4c3c2)nc2ccccc12 InChI=1S/C23H23N5O2/c1-14(2)28-18-7-4-3-6-17(18)25-23(28)26-21(29)16-9-8-15-12-20-22(30)24-10-5-11-27(20)19(15)13-16/h3-4,6-9,12-14H,5,10-11H2,1-2H3,(H,24,30)(H,25,26,29) HZZNLCVNOOMGDD-UHFFFAOYSA-N 50360294 CHEMBL1933281::US9150577, 72 Ribosomal protein S6 kinase alpha-3 Homo sapiens 20 ChEMBL 10.1016/j.bmcl.2011.10.029 10.7270/Q2348KTR 22056746 Kirrane, TM; Boyer, SJ; Burke, J; Guo, X; Snow, RJ; Soleymanzadeh, L; Swinamer, A; Zhang, Y; Madwed, JB; Kashem, M; Kugler, S; O'Neill, MM Boehringer Ingelheim Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50360294 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50360294&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 57400390 136964356 CHEMBL1933281 ZINC73221634 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50199129 CCn1c(NC(=O)c2ccc3cc4C(=O)NCCCn4c3c2)nc2ccccc12 InChI=1S/C22H21N5O2/c1-2-26-17-7-4-3-6-16(17)24-22(26)25-20(28)15-9-8-14-12-19-21(29)23-10-5-11-27(19)18(14)13-15/h3-4,6-9,12-13H,2,5,10-11H2,1H3,(H,23,29)(H,24,25,28) NRGYMIVHSWOTKI-UHFFFAOYSA-N 50360293 CHEMBL1933280::US9150577, 81 Ribosomal protein S6 kinase alpha-3 Homo sapiens 1 ChEMBL 10.1016/j.bmcl.2011.10.029 10.7270/Q2348KTR 22056746 Kirrane, TM; Boyer, SJ; Burke, J; Guo, X; Snow, RJ; Soleymanzadeh, L; Swinamer, A; Zhang, Y; Madwed, JB; Kashem, M; Kugler, S; O'Neill, MM Boehringer Ingelheim Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50360293 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50360293&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 53247439 136964355 CHEMBL1933280 ZINC73221631 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50199130 CN(C)CCCn1c(NC(=O)c2ccc3cc4C(=O)NCC(C)(C)Cn4c3c2)nc2ccccc12 InChI=1S/C27H32N6O2/c1-27(2)16-28-25(35)23-14-18-10-11-19(15-22(18)33(23)17-27)24(34)30-26-29-20-8-5-6-9-21(20)32(26)13-7-12-31(3)4/h5-6,8-11,14-15H,7,12-13,16-17H2,1-4H3,(H,28,35)(H,29,30,34) LQZKYXLZCLMOGP-UHFFFAOYSA-N 50360303 CHEMBL1933290::US9150577, 99 Ribosomal protein S6 kinase alpha-3 Homo sapiens 27 ChEMBL 10.1016/j.bmcl.2011.10.029 10.7270/Q2348KTR 22056746 Kirrane, TM; Boyer, SJ; Burke, J; Guo, X; Snow, RJ; Soleymanzadeh, L; Swinamer, A; Zhang, Y; Madwed, JB; Kashem, M; Kugler, S; O'Neill, MM Boehringer Ingelheim Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50360303 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50360303&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 57398759 136964365 CHEMBL1933290 ZINC82158491 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50199132 Cn1c(NC(=O)c2ccc3cc4C(=O)NCCCn4c3c2)nc2ccccc12 InChI=1S/C21H19N5O2/c1-25-16-6-3-2-5-15(16)23-21(25)24-19(27)14-8-7-13-11-18-20(28)22-9-4-10-26(18)17(13)12-14/h2-3,5-8,11-12H,4,9-10H2,1H3,(H,22,28)(H,23,24,27) WIICYVHPNFINMO-UHFFFAOYSA-N 50360292 CHEMBL1933279::US9150577, 64 Ribosomal protein S6 kinase alpha-3 Homo sapiens 9 ChEMBL 10.1016/j.bmcl.2011.10.029 10.7270/Q2348KTR 22056746 Kirrane, TM; Boyer, SJ; Burke, J; Guo, X; Snow, RJ; Soleymanzadeh, L; Swinamer, A; Zhang, Y; Madwed, JB; Kashem, M; Kugler, S; O'Neill, MM Boehringer Ingelheim Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50360292 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50360292&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 56834880 136964354 CHEMBL1933279 ZINC73224365 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50199133 C[C@H]1CCNC(=O)c2cc3ccc(cc3n12)C(=O)Nc1nc2ccccc2n1CCCN(C)C InChI=1S/C26H30N6O2/c1-17-11-12-27-25(34)23-15-18-9-10-19(16-22(18)32(17)23)24(33)29-26-28-20-7-4-5-8-21(20)31(26)14-6-13-30(2)3/h4-5,7-10,15-17H,6,11-14H2,1-3H3,(H,27,34)(H,28,29,33)/t17-/m0/s1 ZHMXXVNQAFCXKK-KRWDZBQOSA-N 50360302 CHEMBL1933289::US9150577, 94 Ribosomal protein S6 kinase alpha-3 Homo sapiens 14 ChEMBL 10.1016/j.bmcl.2011.10.029 10.7270/Q2348KTR 22056746 Kirrane, TM; Boyer, SJ; Burke, J; Guo, X; Snow, RJ; Soleymanzadeh, L; Swinamer, A; Zhang, Y; Madwed, JB; Kashem, M; Kugler, S; O'Neill, MM Boehringer Ingelheim Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50360302 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50360302&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 53247680 136964364 CHEMBL1933289 ZINC82158489 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50199134 O=C(Nc1cnn(Cc2ccncc2)c1)c1ccc2cc3C(=O)NCCCn3c2c1 InChI=1S/C22H20N6O2/c29-21(26-18-12-25-27(14-18)13-15-4-7-23-8-5-15)17-3-2-16-10-20-22(30)24-6-1-9-28(20)19(16)11-17/h2-5,7-8,10-12,14H,1,6,9,13H2,(H,24,30)(H,26,29) WKUUMSASAHOWGZ-UHFFFAOYSA-N 50360291 CHEMBL1933278::US9150577, 114 Ribosomal protein S6 kinase alpha-3 Homo sapiens 2 ChEMBL 10.1016/j.bmcl.2011.10.029 10.7270/Q2348KTR 22056746 Kirrane, TM; Boyer, SJ; Burke, J; Guo, X; Snow, RJ; Soleymanzadeh, L; Swinamer, A; Zhang, Y; Madwed, JB; Kashem, M; Kugler, S; O'Neill, MM Boehringer Ingelheim Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50360291 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50360291&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 53247560 136964353 CHEMBL1933278 ZINC73224364 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50199136 C[C@@H]1CCNC(=O)c2cc3ccc(cc3n12)C(=O)Nc1nc2ccccc2n1CCCN(C)C InChI=1S/C26H30N6O2/c1-17-11-12-27-25(34)23-15-18-9-10-19(16-22(18)32(17)23)24(33)29-26-28-20-7-4-5-8-21(20)31(26)14-6-13-30(2)3/h4-5,7-10,15-17H,6,11-14H2,1-3H3,(H,27,34)(H,28,29,33)/t17-/m1/s1 ZHMXXVNQAFCXKK-QGZVFWFLSA-N 50360301 CHEMBL1933288::US9150577, 93 Ribosomal protein S6 kinase alpha-3 Homo sapiens 1 ChEMBL 10.1016/j.bmcl.2011.10.029 10.7270/Q2348KTR 22056746 Kirrane, TM; Boyer, SJ; Burke, J; Guo, X; Snow, RJ; Soleymanzadeh, L; Swinamer, A; Zhang, Y; Madwed, JB; Kashem, M; Kugler, S; O'Neill, MM Boehringer Ingelheim Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50360301 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50360301&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 53246941 136964363 CHEMBL1933288 ZINC82158487 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50199137 O=C(Nc1cnn(Cc2ccccn2)c1)c1ccc2cc3C(=O)NCCCn3c2c1 InChI=1S/C22H20N6O2/c29-21(26-18-12-25-27(14-18)13-17-4-1-2-7-23-17)16-6-5-15-10-20-22(30)24-8-3-9-28(20)19(15)11-16/h1-2,4-7,10-12,14H,3,8-9,13H2,(H,24,30)(H,26,29) RXYDOJKKUXRPAA-UHFFFAOYSA-N 50360290 CHEMBL1933277 Ribosomal protein S6 kinase alpha-3 Homo sapiens 10 ChEMBL 10.1016/j.bmcl.2011.10.029 10.7270/Q2348KTR 22056746 Kirrane, TM; Boyer, SJ; Burke, J; Guo, X; Snow, RJ; Soleymanzadeh, L; Swinamer, A; Zhang, Y; Madwed, JB; Kashem, M; Kugler, S; O'Neill, MM Boehringer Ingelheim Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50360290 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50360290&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 57398716 136964352 CHEMBL1933277 ZINC73224363 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50199139 CCn1c(NC(=O)c2ccc3cc4C(=O)NCCCn4c3c2)nc2cccnc12 InChI=1S/C21H20N6O2/c1-2-26-18-15(5-3-8-22-18)24-21(26)25-19(28)14-7-6-13-11-17-20(29)23-9-4-10-27(17)16(13)12-14/h3,5-8,11-12H,2,4,9-10H2,1H3,(H,23,29)(H,24,25,28) WMGGYIKBPUVPFM-UHFFFAOYSA-N 50360300 CHEMBL1933287::US9150577, 105 Ribosomal protein S6 kinase alpha-3 Homo sapiens 4 ChEMBL 10.1016/j.bmcl.2011.10.029 10.7270/Q2348KTR 22056746 Kirrane, TM; Boyer, SJ; Burke, J; Guo, X; Snow, RJ; Soleymanzadeh, L; Swinamer, A; Zhang, Y; Madwed, JB; Kashem, M; Kugler, S; O'Neill, MM Boehringer Ingelheim Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50360300 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50360300&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 57400430 136964362 CHEMBL1933287 ZINC82158485 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50199141 CN(C)CCCn1c(NC(=O)c2ccc3cc4C(=O)NCCCn4c3c2)nc2ccc(Cl)cc12 InChI=1S/C25H27ClN6O2/c1-30(2)10-4-12-32-21-15-18(26)7-8-19(21)28-25(32)29-23(33)17-6-5-16-13-22-24(34)27-9-3-11-31(22)20(16)14-17/h5-8,13-15H,3-4,9-12H2,1-2H3,(H,27,34)(H,28,29,33) VCZQSUBZCZZLAX-UHFFFAOYSA-N 50360299 CHEMBL1933286::US9150577, 54 Ribosomal protein S6 kinase alpha-3 Homo sapiens 20 ChEMBL 10.1016/j.bmcl.2011.10.029 10.7270/Q2348KTR 22056746 Kirrane, TM; Boyer, SJ; Burke, J; Guo, X; Snow, RJ; Soleymanzadeh, L; Swinamer, A; Zhang, Y; Madwed, JB; Kashem, M; Kugler, S; O'Neill, MM Boehringer Ingelheim Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50360299 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50360299&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 57393506 136964361 CHEMBL1933286 ZINC73224075 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50199143 CCn1c(NC(=O)c2ccc3cc4C(=O)NCCCn4c3c2)nc2ccc(Cl)cc12 InChI=1S/C22H20ClN5O2/c1-2-27-18-12-15(23)6-7-16(18)25-22(27)26-20(29)14-5-4-13-10-19-21(30)24-8-3-9-28(19)17(13)11-14/h4-7,10-12H,2-3,8-9H2,1H3,(H,24,30)(H,25,26,29) QYLAYPRSSJNQDC-UHFFFAOYSA-N 50360298 CHEMBL1933285::US9150577, 53 Ribosomal protein S6 kinase alpha-3 Homo sapiens 12 ChEMBL 10.1016/j.bmcl.2011.10.029 10.7270/Q2348KTR 22056746 Kirrane, TM; Boyer, SJ; Burke, J; Guo, X; Snow, RJ; Soleymanzadeh, L; Swinamer, A; Zhang, Y; Madwed, JB; Kashem, M; Kugler, S; O'Neill, MM Boehringer Ingelheim Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50360298 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50360298&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 53247559 136964360 CHEMBL1933285 ZINC73222316 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50199145 CCn1c(NC(=O)c2ccc3cc4C(=O)NCCCn4c3c2)nc2cc(Cl)ccc12 InChI=1S/C22H20ClN5O2/c1-2-27-17-7-6-15(23)12-16(17)25-22(27)26-20(29)14-5-4-13-10-19-21(30)24-8-3-9-28(19)18(13)11-14/h4-7,10-12H,2-3,8-9H2,1H3,(H,24,30)(H,25,26,29) GVDISXKMIUKGIP-UHFFFAOYSA-N 50360297 CHEMBL1933284 Ribosomal protein S6 kinase alpha-3 Homo sapiens 6 ChEMBL 10.1016/j.bmcl.2011.10.029 10.7270/Q2348KTR 22056746 Kirrane, TM; Boyer, SJ; Burke, J; Guo, X; Snow, RJ; Soleymanzadeh, L; Swinamer, A; Zhang, Y; Madwed, JB; Kashem, M; Kugler, S; O'Neill, MM Boehringer Ingelheim Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50360297 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50360297&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 57395227 136964359 CHEMBL1933284 ZINC73222314 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50199146 CN(C)CCCn1c(NC(=O)c2ccc3cc4C(=O)NCCCn4c3c2)nc2ccccc12 InChI=1S/C25H28N6O2/c1-29(2)12-6-14-31-20-8-4-3-7-19(20)27-25(31)28-23(32)18-10-9-17-15-22-24(33)26-11-5-13-30(22)21(17)16-18/h3-4,7-10,15-16H,5-6,11-14H2,1-2H3,(H,26,33)(H,27,28,32) KAKNBLVUBRXYQD-UHFFFAOYSA-N 50360296 CHEMBL1933283::US9150577, 96 Ribosomal protein S6 kinase alpha-3 Homo sapiens 21 ChEMBL 10.1016/j.bmcl.2011.10.029 10.7270/Q2348KTR 22056746 Kirrane, TM; Boyer, SJ; Burke, J; Guo, X; Snow, RJ; Soleymanzadeh, L; Swinamer, A; Zhang, Y; Madwed, JB; Kashem, M; Kugler, S; O'Neill, MM Boehringer Ingelheim Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50360296 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50360296&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 57403971 136964358 CHEMBL1933283 ZINC73221640 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50199148 O=C(Nc1cc(no1)-c1ccccc1)c1ccc2cc3C(=O)NCCCn3c2c1 InChI=1S/C22H18N4O3/c27-21(24-20-13-17(25-29-20)14-5-2-1-3-6-14)16-8-7-15-11-19-22(28)23-9-4-10-26(19)18(15)12-16/h1-3,5-8,11-13H,4,9-10H2,(H,23,28)(H,24,27) UERCXNOQFSTSOY-UHFFFAOYSA-N 50360286 CHEMBL1933146::US9150577, 214 Ribosomal protein S6 kinase alpha-3 Homo sapiens 360 ChEMBL 10.1016/j.bmcl.2011.10.029 10.7270/Q2348KTR 22056746 Kirrane, TM; Boyer, SJ; Burke, J; Guo, X; Snow, RJ; Soleymanzadeh, L; Swinamer, A; Zhang, Y; Madwed, JB; Kashem, M; Kugler, S; O'Neill, MM Boehringer Ingelheim Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50360286 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50360286&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 57391813 136964348 CHEMBL1933146 ZINC73220351 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50199152 O=C(Nc1cc(Cc2ccccc2)no1)c1ccc2cc3C(=O)NCCCn3c2c1 InChI=1S/C23H20N4O3/c28-22(25-21-14-18(26-30-21)11-15-5-2-1-3-6-15)17-8-7-16-12-20-23(29)24-9-4-10-27(20)19(16)13-17/h1-3,5-8,12-14H,4,9-11H2,(H,24,29)(H,25,28) JMEYCQCGWJJILQ-UHFFFAOYSA-N 50360287 CHEMBL1933147 Ribosomal protein S6 kinase alpha-3 Homo sapiens 130 ChEMBL 10.1016/j.bmcl.2011.10.029 10.7270/Q2348KTR 22056746 Kirrane, TM; Boyer, SJ; Burke, J; Guo, X; Snow, RJ; Soleymanzadeh, L; Swinamer, A; Zhang, Y; Madwed, JB; Kashem, M; Kugler, S; O'Neill, MM Boehringer Ingelheim Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50360287 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50360287&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 57400466 136964349 CHEMBL1933147 ZINC73220354 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50199158 Cn1cc(NC(=O)c2ccc3cc4C(=O)NCCCn4c3c2)cn1 InChI=1S/C17H17N5O2/c1-21-10-13(9-19-21)20-16(23)12-4-3-11-7-15-17(24)18-5-2-6-22(15)14(11)8-12/h3-4,7-10H,2,5-6H2,1H3,(H,18,24)(H,20,23) PXRIUZVVLPVSSH-UHFFFAOYSA-N 50360288 CHEMBL1933148::US9150577, 23 Ribosomal protein S6 kinase alpha-3 Homo sapiens 790 ChEMBL 10.1016/j.bmcl.2011.10.029 10.7270/Q2348KTR 22056746 Kirrane, TM; Boyer, SJ; Burke, J; Guo, X; Snow, RJ; Soleymanzadeh, L; Swinamer, A; Zhang, Y; Madwed, JB; Kashem, M; Kugler, S; O'Neill, MM Boehringer Ingelheim Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50360288 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50360288&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 57398793 136964350 CHEMBL1933148 ZINC73220358 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50199161 O=C(Nc1cnn(CC2CCCCC2)c1)c1ccc2cc3C(=O)NCCCn3c2c1 InChI=1S/C23H27N5O2/c29-22(26-19-13-25-27(15-19)14-16-5-2-1-3-6-16)18-8-7-17-11-21-23(30)24-9-4-10-28(21)20(17)12-18/h7-8,11-13,15-16H,1-6,9-10,14H2,(H,24,30)(H,26,29) YVUHNKZPGGBYDH-UHFFFAOYSA-N 50360289 CHEMBL1933149::US9150577, 33 Ribosomal protein S6 kinase alpha-3 Homo sapiens 120 ChEMBL 10.1016/j.bmcl.2011.10.029 10.7270/Q2348KTR 22056746 Kirrane, TM; Boyer, SJ; Burke, J; Guo, X; Snow, RJ; Soleymanzadeh, L; Swinamer, A; Zhang, Y; Madwed, JB; Kashem, M; Kugler, S; O'Neill, MM Boehringer Ingelheim Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50360289 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50360289&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 57395253 136964351 CHEMBL1933149 ZINC82158244 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50199162 Cc1cc(NC(=O)c2ccc3cc4C(=O)NCCCn4c3c2)on1 InChI=1S/C17H16N4O3/c1-10-7-15(24-20-10)19-16(22)12-4-3-11-8-14-17(23)18-5-2-6-21(14)13(11)9-12/h3-4,7-9H,2,5-6H2,1H3,(H,18,23)(H,19,22) SPOWSXDVDODVEW-UHFFFAOYSA-N 50360282 CHEMBL1933143::US9150577, 193 Ribosomal protein S6 kinase alpha-3 Homo sapiens 200 ChEMBL 10.1016/j.bmcl.2011.10.029 10.7270/Q2348KTR 22056746 Kirrane, TM; Boyer, SJ; Burke, J; Guo, X; Snow, RJ; Soleymanzadeh, L; Swinamer, A; Zhang, Y; Madwed, JB; Kashem, M; Kugler, S; O'Neill, MM Boehringer Ingelheim Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50360282 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50360282&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 56835180 136964344 CHEMBL1933143 ZINC73219396 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50199164 O=C(Nc1cc(no1)C1CC1)c1ccc2cc3C(=O)NCCCn3c2c1 InChI=1S/C19H18N4O3/c24-18(21-17-10-14(22-26-17)11-2-3-11)13-5-4-12-8-16-19(25)20-6-1-7-23(16)15(12)9-13/h4-5,8-11H,1-3,6-7H2,(H,20,25)(H,21,24) UJAUSTYSRUCHNY-UHFFFAOYSA-N 50360284 CHEMBL1933068::US9150577, 198 Ribosomal protein S6 kinase alpha-3 Homo sapiens 250 ChEMBL 10.1016/j.bmcl.2011.10.029 10.7270/Q2348KTR 22056746 Kirrane, TM; Boyer, SJ; Burke, J; Guo, X; Snow, RJ; Soleymanzadeh, L; Swinamer, A; Zhang, Y; Madwed, JB; Kashem, M; Kugler, S; O'Neill, MM Boehringer Ingelheim Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50360284 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50360284&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 57398752 136964346 CHEMBL1933068 ZINC73219401 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50199166 CC(C)c1cc(NC(=O)c2ccc3cc4C(=O)NCCCn4c3c2)on1 InChI=1S/C19H20N4O3/c1-11(2)14-10-17(26-22-14)21-18(24)13-5-4-12-8-16-19(25)20-6-3-7-23(16)15(12)9-13/h4-5,8-11H,3,6-7H2,1-2H3,(H,20,25)(H,21,24) JBOKTWNEIMBJNQ-UHFFFAOYSA-N 50360285 CHEMBL1933145::US9150577, 196 Ribosomal protein S6 kinase alpha-3 Homo sapiens 460 ChEMBL 10.1016/j.bmcl.2011.10.029 10.7270/Q2348KTR 22056746 Kirrane, TM; Boyer, SJ; Burke, J; Guo, X; Snow, RJ; Soleymanzadeh, L; Swinamer, A; Zhang, Y; Madwed, JB; Kashem, M; Kugler, S; O'Neill, MM Boehringer Ingelheim Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50360285 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50360285&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 57400465 136964347 CHEMBL1933145 ZINC73219404 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50199167 O=C(Nc1nc2ccccc2n1-c1ccccc1)c1ccc2cc3C(=O)NCCCn3c2c1 InChI=1S/C26H21N5O2/c32-24(18-12-11-17-15-23-25(33)27-13-6-14-30(23)22(17)16-18)29-26-28-20-9-4-5-10-21(20)31(26)19-7-2-1-3-8-19/h1-5,7-12,15-16H,6,13-14H2,(H,27,33)(H,28,29,32) YARFNYLGLQVPEB-UHFFFAOYSA-N 50360295 CHEMBL1933282::US9150577, 76 Ribosomal protein S6 kinase alpha-3 Homo sapiens 61 ChEMBL 10.1016/j.bmcl.2011.10.029 10.7270/Q2348KTR 22056746 Kirrane, TM; Boyer, SJ; Burke, J; Guo, X; Snow, RJ; Soleymanzadeh, L; Swinamer, A; Zhang, Y; Madwed, JB; Kashem, M; Kugler, S; O'Neill, MM Boehringer Ingelheim Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50360295 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50360295&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 57400429 136964357 CHEMBL1933282 ZINC73221637 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50214476 Cc1cn2c(cnc2c(Nc2cc(CN3CCC(F)(F)C3)ns2)n1)-c1cn[nH]c1 InChI=1S/C18H18F2N8S/c1-11-8-28-14(12-5-22-23-6-12)7-21-17(28)16(24-11)25-15-4-13(26-29-15)9-27-3-2-18(19,20)10-27/h4-8H,2-3,9-10H2,1H3,(H,22,23)(H,24,25) JVAFTPDILUBIGR-UHFFFAOYSA-N 50335188 CHEMBL1650545::CHEMBL1650551::N-[3-[(3,3-Difluoro-1-pyrrolidinyl)methyl]-5-isothiazolyl]-6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-amine Hydrochloride Ribosomal protein S6 kinase alpha-3 Homo sapiens >100 ChEMBL 10.1021/jm1010995 10.7270/Q2VM4D76 21128646 Kerekes, AD; Esposite, SJ; Tagat, JR; Xiao, Y; Terracina, GA Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50335188 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50335188&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 25145145 125085290 CHEMBL1650545CHEMBL1650551 ZINC66101759 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50224970 [O-][N+](=O)c1ccccc1-c1n[nH]cc1C=C1C(=O)Nc2ccccc12 InChI=1S/C18H12N4O3/c23-18-14(12-5-1-3-7-15(12)20-18)9-11-10-19-21-17(11)13-6-2-4-8-16(13)22(24)25/h1-10H,(H,19,21)(H,20,23) XLYVQVWMTOLDNL-UHFFFAOYSA-N 50431812 CHEMBL2347053 Ribosomal protein S6 kinase alpha-3 Homo sapiens 1.6 ChEMBL 10.1016/j.bmc.2013.01.047 10.7270/Q2GQ704N 23434140 Zhong, Y; Xue, M; Zhao, X; Yuan, J; Liu, X; Huang, J; Zhao, Z; Li, H; Xu, Y East China University of Science and Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50431812 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50431812&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 5703619 164160687 CHEMBL2347053 ZINC12369272 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50224971 O=C1Nc2ccccc2\C1=C\c1ccco1 InChI=1S/C13H9NO2/c15-13-11(8-9-4-3-7-16-9)10-5-1-2-6-12(10)14-13/h1-8H,(H,14,15)/b11-8- PGZGBDVILWVGSF-FLIBITNWSA-N 50431816 CHEMBL2347073 Ribosomal protein S6 kinase alpha-3 Homo sapiens 7760 ChEMBL 10.1016/j.bmc.2013.01.047 10.7270/Q2GQ704N 23434140 Zhong, Y; Xue, M; Zhao, X; Yuan, J; Liu, X; Huang, J; Zhao, Z; Li, H; Xu, Y East China University of Science and Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50431816 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50431816&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 5476622 164160691 CHEMBL2347073 ZINC00136914 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50230226 CO[C@@H]1[C@@H](C[C@H]2O[C@]1(C)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13)N(C)C(=O)c1ccccc1 InChI=1S/C35H30N4O4/c1-35-32(42-3)25(37(2)34(41)19-11-5-4-6-12-19)17-26(43-35)38-23-15-9-7-13-20(23)28-29-22(18-36-33(29)40)27-21-14-8-10-16-24(21)39(35)31(27)30(28)38/h4-16,25-26,32H,17-18H2,1-3H3,(H,36,40)/t25-,26-,32-,35+/m1/s1 BMGQWWVMWDBQGC-IIFHNQTCSA-N 50326053 CHEMBL608533::PKC-412 Ribosomal protein S6 kinase alpha-3 Homo sapiens 740 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50326053 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50326053&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 2K2 4NCT 9829523 123105168 63452 CHEMBL608533 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50229522 CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1 HKSZLNNOFSGOKW-FYTWVXJKSA-N 2579 (2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.1^{2,6}.0^{7,28}.0^{8,13}.0^{15,19}.0^{20,27}.0^{21,26}]nonacosa-8(13),9,11,14(28),15(19),20(27),21(26),22,24-nonaen-16-one::CHEMBL388978::Staurosporin, 4::Staurosporine::Staurosporine, 8::US9206188, Staurosporine::US9226923, Staurosporine Ribosomal protein S6 kinase alpha-3 Homo sapiens 69 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=2579 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=2579&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search STO 1AQ1,1BYG,1E8Z,1NVR,1NXK,1OKY,1Q3D,1QPD,1QPJ,1SM2,1SNU,1STC,1U59,1WVY,1XBC,1XJD,1YHS,2BUJ,2CLQ,2DQ7,2GCD,2HW7,2ITQ,2ITU,2ITW,2NRY,2OIC 44259 8032349 15738 CHEMBL388978 346 C02079 ZINC03814434 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50244394 CC(=O)c1ccc(cc1)N1CCN(CC1)C(=O)CN1CC[C@H](C1)C(=O)Nc1ccc(O)c(Cl)c1 InChI=1S/C25H29ClN4O4/c1-17(31)18-2-5-21(6-3-18)29-10-12-30(13-11-29)24(33)16-28-9-8-19(15-28)25(34)27-20-4-7-23(32)22(26)14-20/h2-7,14,19,32H,8-13,15-16H2,1H3,(H,27,34)/t19-/m1/s1 YPNCCYRKEHPJMN-LJQANCHMSA-N 50030881 CHEMBL3356117 Ribosomal protein S6 kinase alpha-3 Homo sapiens 27000 ChEMBL 10.1021/jm500847m 10.7270/Q2Q52R6D 25313996 Deng, Y; Shipps, GW; Cooper, A; English, JM; Annis, DA; Carr, D; Nan, Y; Wang, T; Zhu, HY; Chuang, CC; Dayananth, P; Hruza, AW; Xiao, L; Jin, W; Kirschmeier, P; Windsor, WT; Samatar, AA Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50030881 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50030881&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 3G7 4QYY 58985201 313065931 CHEMBL3356117 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50270798 COc1ccccc1C1=C(C(=O)NC1=O)c1cn(CCCNC(=O)OC(C)(C)C)c2ncccc12 InChI=1S/C26H28N4O5/c1-26(2,3)35-25(33)28-13-8-14-30-15-18(16-10-7-12-27-22(16)30)21-20(23(31)29-24(21)32)17-9-5-6-11-19(17)34-4/h5-7,9-12,15H,8,13-14H2,1-4H3,(H,28,33)(H,29,31,32) MJSXSLBYCSPRHR-UHFFFAOYSA-N 50147458 (3-{3-[4-(2-Methoxy-phenyl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl]-pyrrolo[2,3-b]pyridin-1-yl}-propyl)-carbamic acid tert-butyl ester::CHEMBL109981 Ribosomal protein S6 kinase alpha-3 Homo sapiens 640 ChEMBL 10.1016/j.bmcl.2004.03.090 10.7270/Q2W958NH 15149684 Zhang, HC; Ye, H; Conway, BR; Derian, CK; Addo, MF; Kuo, GH; Hecker, LR; Croll, DR; Li, J; Westover, L; Xu, JZ; Look, R; Demarest, KT; Andrade-Gordon, P; Damiano, BP; Maryanoff, BE Johnson & Johnson Pharmaceutical Research & Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50147458 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50147458&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 10073694 104035950 CHEMBL109981 ZINC03819659 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50268495 Clc1ccc(cc1)-c1ccc(o1)-c1nccn1-c1ccc(cc1)N1CCNCC1 InChI=1S/C23H21ClN4O/c24-18-3-1-17(2-4-18)21-9-10-22(29-21)23-26-13-16-28(23)20-7-5-19(6-8-20)27-14-11-25-12-15-27/h1-10,13,16,25H,11-12,14-15H2 SLLRTLCGZRODTB-UHFFFAOYSA-N 50045370 CHEMBL3314140 Ribosomal protein S6 kinase alpha-3 Homo sapiens >30000 ChEMBL 10.1016/j.bmcl.2014.05.024 10.7270/Q2F47QR7 24913714 Xiao, D; Zhu, X; Sofolarides, M; Degrado, S; Shao, N; Rao, A; Chen, X; Aslanian, R; Fossetta, J; Tian, F; Trivedi, P; Lundell, D; Palani, A Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50045370 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50045370&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 91971978 103976419 CHEMBL3314140 ZINC13282471 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50270841 COCCCn1cc(C2=C(C(=O)NC2=O)c2ccccc2O)c2cccnc12 InChI=1S/C21H19N3O4/c1-28-11-5-10-24-12-15(13-7-4-9-22-19(13)24)18-17(20(26)23-21(18)27)14-6-2-3-8-16(14)25/h2-4,6-9,12,25H,5,10-11H2,1H3,(H,23,26,27) DZVIVYUYURSYNH-UHFFFAOYSA-N 50147457 3-(2-Hydroxy-phenyl)-4-[1-(3-hydroxy-propyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]-pyrrole-2,5-dione::CHEMBL109944 Ribosomal protein S6 kinase alpha-3 Homo sapiens 2000 ChEMBL 10.1016/j.bmcl.2004.03.090 10.7270/Q2W958NH 15149684 Zhang, HC; Ye, H; Conway, BR; Derian, CK; Addo, MF; Kuo, GH; Hecker, LR; Croll, DR; Li, J; Westover, L; Xu, JZ; Look, R; Demarest, KT; Andrade-Gordon, P; Damiano, BP; Maryanoff, BE Johnson & Johnson Pharmaceutical Research & Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50147457 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50147457&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 9999648 104035949 CHEMBL109944 ZINC26968370 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50265365 CC(=O)O[C@H]1CC[C@@H](Oc2c(oc3cc(O)cc(O)c3c2=O)-c2ccc(O)cc2)[C@H](O)[C@@H]1OC(C)=O InChI=1S/C25H24O11/c1-11(26)33-18-8-7-17(21(31)24(18)34-12(2)27)35-25-22(32)20-16(30)9-15(29)10-19(20)36-23(25)13-3-5-14(28)6-4-13/h3-6,9-10,17-18,21,24,28-31H,7-8H2,1-2H3/t17-,18+,21+,24-/m1/s1 OTPCQHIGGWABCT-CVOKININSA-N 50044088 CHEMBL3356441 Ribosomal protein S6 kinase alpha-3 Homo sapiens 8930 ChEMBL 10.1021/ml5004525 10.7270/Q2RR20V0 25589938 Li, M; Li, Y; Mrozowski, RM; Sandusky, ZM; Shan, M; Song, X; Wu, B; Zhang, Q; Lannigan, DA; O'Doherty, GA Northeastern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50044088 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50044088&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 118721541 313068092 CHEMBL3356441 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50265366 C[C@@H]1C[C@@H](Oc2c(oc3cc(O)cc(O)c3c2=O)-c2ccc(O)cc2)[C@H](OC(C)=O)[C@H](O)[C@H]1OC(C)=O InChI=1S/C26H26O11/c1-11-8-19(25(35-13(3)28)22(33)23(11)34-12(2)27)37-26-21(32)20-17(31)9-16(30)10-18(20)36-24(26)14-4-6-15(29)7-5-14/h4-7,9-11,19,22-23,25,29-31,33H,8H2,1-3H3/t11-,19-,22-,23+,25+/m1/s1 WADXCMSONJVPKX-LTBIHHBXSA-N 50044089 CHEMBL3356439 Ribosomal protein S6 kinase alpha-3 Homo sapiens 1600 ChEMBL 10.1021/ml5004525 10.7270/Q2RR20V0 25589938 Li, M; Li, Y; Mrozowski, RM; Sandusky, ZM; Shan, M; Song, X; Wu, B; Zhang, Q; Lannigan, DA; O'Doherty, GA Northeastern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50044089 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50044089&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 51029719 313068093 CHEMBL3356439 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50265367 C[C@@H]1C[C@@H](Oc2c(oc3cc(O)cc(O)c3c2=O)-c2ccc(O)cc2)[C@H](O)[C@H](O)[C@H]1OC(C)=O InChI=1S/C24H24O10/c1-10-7-17(19(29)21(31)22(10)32-11(2)25)34-24-20(30)18-15(28)8-14(27)9-16(18)33-23(24)12-3-5-13(26)6-4-12/h3-6,8-10,17,19,21-22,26-29,31H,7H2,1-2H3/t10-,17-,19+,21+,22+/m1/s1 HEDQIXPQCXBXDD-HZQSEOSJSA-N 50044090 CHEMBL3356437 Ribosomal protein S6 kinase alpha-3 Homo sapiens 1230 ChEMBL 10.1021/ml5004525 10.7270/Q2RR20V0 25589938 Li, M; Li, Y; Mrozowski, RM; Sandusky, ZM; Shan, M; Song, X; Wu, B; Zhang, Q; Lannigan, DA; O'Doherty, GA Northeastern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50044090 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50044090&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 51029632 313068094 CHEMBL3356437 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50265368 C[C@@H]1C[C@@H](Oc2c(oc3cc(O)cc(O)c3c2=O)-c2ccc(O)cc2)[C@H](O)[C@H](OC(C)=O)[C@H]1OC(C)=O InChI=1S/C26H26O11/c1-11-8-19(21(32)25(35-13(3)28)23(11)34-12(2)27)37-26-22(33)20-17(31)9-16(30)10-18(20)36-24(26)14-4-6-15(29)7-5-14/h4-7,9-11,19,21,23,25,29-32H,8H2,1-3H3/t11-,19-,21+,23+,25+/m1/s1 LLFRXYFZGCTTDG-OTGJNIAMSA-N 50044091 CHEMBL3356435 Ribosomal protein S6 kinase alpha-3 Homo sapiens 270 ChEMBL 10.1021/ml5004525 10.7270/Q2RR20V0 25589938 Li, M; Li, Y; Mrozowski, RM; Sandusky, ZM; Shan, M; Song, X; Wu, B; Zhang, Q; Lannigan, DA; O'Doherty, GA Northeastern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50044091 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50044091&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 51029720 313068095 CHEMBL3356435 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50265370 C[C@@H]1O[C@@H](Oc2c(O)c3c(cc(O)cc3=O)oc2-c2ccc(O)cc2)[C@H](O)[C@H](OC(C)=O)[C@H]1OC(C)=O InChI=1S/C25H24O12/c1-10-21(34-11(2)26)24(35-12(3)27)20(32)25(33-10)37-23-19(31)18-16(30)8-15(29)9-17(18)36-22(23)13-4-6-14(28)7-5-13/h4-10,20-21,24-25,28-29,31-32H,1-3H3/t10-,20+,21-,24-,25-/m0/s1 POZDUGKSCAGWQI-IGKKHSBFSA-N 50241294 CHEMBL240954::SL-0101::kaempferol 3-O-(3'',4''-di-O-acetyl-alpha-L-rhamnopyranoside::kaempferol-3-O-(3,4-di-O-acetyl-alpha-L-rhamnopyranoside) Ribosomal protein S6 kinase alpha-3 Homo sapiens 370 ChEMBL 10.1021/ml5004525 10.7270/Q2RR20V0 25589938 Li, M; Li, Y; Mrozowski, RM; Sandusky, ZM; Shan, M; Song, X; Wu, B; Zhang, Q; Lannigan, DA; O'Doherty, GA Northeastern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50241294 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50241294&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 10459196 104098696 CHEMBL240954 ZINC28875874 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50291333 C[C@@H]1O[C@@H](Oc2c(O)c3c(cc(O)cc3=O)oc2-c2ccc(O)cc2)[C@H](O)[C@H](OC(C)=O)[C@H]1OC(C)=O InChI=1S/C25H24O12/c1-10-21(34-11(2)26)24(35-12(3)27)20(32)25(33-10)37-23-19(31)18-16(30)8-15(29)9-17(18)36-22(23)13-4-6-14(28)7-5-13/h4-10,20-21,24-25,28-29,31-32H,1-3H3/t10-,20+,21-,24-,25-/m0/s1 POZDUGKSCAGWQI-IGKKHSBFSA-N 50241294 CHEMBL240954::SL-0101::kaempferol 3-O-(3'',4''-di-O-acetyl-alpha-L-rhamnopyranoside::kaempferol-3-O-(3,4-di-O-acetyl-alpha-L-rhamnopyranoside) Ribosomal protein S6 kinase alpha-3 Homo sapiens 89 ChEMBL 10.1016/j.ejmech.2014.08.011 10.7270/Q2MG7R51 25147152 Rajendran, P; Rengarajan, T; Nandakumar, N; Palaniswami, R; Nishigaki, Y; Nishigaki, I NPO-International Laboratory of Biochemistry http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50241294 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50241294&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 10459196 104098696 CHEMBL240954 ZINC28875874 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50310137 Cc1ccc(cc1)-c1cn(CCCO)c2ncnc(N)c12 InChI=1S/C16H18N4O/c1-11-3-5-12(6-4-11)13-9-20(7-2-8-21)16-14(13)15(17)18-10-19-16/h3-6,9-10,21H,2,7-8H2,1H3,(H2,17,18,19) USWQTQGAOQGPHR-UHFFFAOYSA-N 50248766 3-(4-amino-5-p-tolyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)propan-1-ol::CHEMBL473965 Ribosomal protein S6 kinase alpha-3 Homo sapiens 1200000 ChEMBL 10.1126/science1108367 10.7270/Q20G3JX9 15919995 Cohen, MS; Zhang, C; Shokat, KM; Taunton, J University of California http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50248766 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50248766&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 44565316 104103318 CHEMBL473965 ZINC40405997 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50310140 Cc1ccc(cc1)-c1c(C(=O)CF)n(CCCO)c2ncnc(N)c12 InChI=1S/C18H19FN4O2/c1-11-3-5-12(6-4-11)14-15-17(20)21-10-22-18(15)23(7-2-8-24)16(14)13(25)9-19/h3-6,10,24H,2,7-9H2,1H3,(H2,20,21,22) IKLGYJACVCXYIL-UHFFFAOYSA-N 50248765 1-(4-amino-7-(3-hydroxypropyl)-5-p-tolyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl)-2-fluoroethanone::CHEMBL515414 Ribosomal protein S6 kinase alpha-3 Homo sapiens 15000 ChEMBL 10.1126/science1108367 10.7270/Q20G3JX9 15919995 Cohen, MS; Zhang, C; Shokat, KM; Taunton, J University of California http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50248765 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50248765&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 644243 104103317 CHEMBL515414 ZINC06718642 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50296503 CCN(CC)CCNC(=O)c1c(C)[nH]c(\C=C2/C(=O)Nc3ccc(F)cc23)c1C InChI=1S/C22H27FN4O2/c1-5-27(6-2)10-9-24-22(29)20-13(3)19(25-14(20)4)12-17-16-11-15(23)7-8-18(16)26-21(17)28/h7-8,11-12,25H,5-6,9-10H2,1-4H3,(H,24,29)(H,26,28)/b17-12- WINHZLLDWRZWRT-ATVHPVEESA-N 4814 CHEMBL535::N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide::N-[2-(diethylamino)ethyl]-5-{[(3Z)-5-fluoro-2-oxo-2,3-dihydro-1H-indol-3-ylidene]methyl}-2,4-dimethyl-1H-pyrrole-3-carboxamide::SU11248::SUNITINIB::SUNITINIB MALATE::US10464902, Sunitinib::US9163010, Sunitinib::US9914707, SU11248 Ribosomal protein S6 kinase alpha-3 Homo sapiens 55 ChEMBL 10.1038/nbt1068 10.7270/Q2V69J3T 15711537 Fabian, MA; Biggs, WH; Treiber, DK; Atteridge, CE; Azimioara, MD; Benedetti, MG; Carter, TA; Ciceri, P; Edeen, PT; Floyd, M; Ford, JM; Galvin, M; Gerlach, JL; Grotzfeld, RM; Herrgard, S; Insko, DE; Insko, MA; Lai, AG; Lelias, JM; Mehta, SA; Milanov, ZV; Velasco, AM; Wodicka, LM; Patel, HK; Zarrinkar, PP; Lockhart, DJ Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=4814 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=4814&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search B49 6NG0,4KS8,3G0F,3G0E,2Y7J,6JOK,6M11,3MIY,3TI1,4QMZ,6V0X,6NFZ,6NFY,4AGD 5329102 8034462 38940 CHEMBL535 DB01268 5713 ZINC03964325 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50296785 CN(C)C[C@@H]1CCn2cc(C3=C(C(=O)NC3=O)c3cn(CCO1)c1ccccc31)c1ccccc21 InChI=1S/C28H28N4O3/c1-30(2)15-18-11-12-31-16-21(19-7-3-5-9-23(19)31)25-26(28(34)29-27(25)33)22-17-32(13-14-35-18)24-10-6-4-8-20(22)24/h3-10,16-18H,11-15H2,1-2H3,(H,29,33,34)/t18-/m0/s1 ZCBUQCWBWNUWSU-SFHVURJKSA-N 17055 (18S)-18-[(dimethylamino)methyl]-17-oxa-4,14,21-triazahexacyclo[19.6.1.1^{7,14}.0^{2,6}.0^{8,13}.0^{22,27}]nonacosa-1(28),2(6),7(29),8(13),9,11,22(27),23,25-nonaene-3,5-dione::(9S)-9-[(dimethylamino)methyl]-6,7,10,11-tetrahydro-9H,18H-5,21:12,17-di(metheno)dibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecine-18,20(19H)-dione::K00587a::LY 333531::LY-333531::LY333531::Ruboxistaurin::cid_153999 Ribosomal protein S6 kinase alpha-3 Homo sapiens 2200 ChEMBL 10.1038/nbt1068 10.7270/Q2V69J3T 15711537 Fabian, MA; Biggs, WH; Treiber, DK; Atteridge, CE; Azimioara, MD; Benedetti, MG; Carter, TA; Ciceri, P; Edeen, PT; Floyd, M; Ford, JM; Galvin, M; Gerlach, JL; Grotzfeld, RM; Herrgard, S; Insko, DE; Insko, MA; Lai, AG; Lelias, JM; Mehta, SA; Milanov, ZV; Velasco, AM; Wodicka, LM; Patel, HK; Zarrinkar, PP; Lockhart, DJ Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17055 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17055&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search LY4 2J2I,1UU3 153999 46517285 5263 ZINC03812168 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50375316 O=C1N=C(NCc2cccs2)SC1=Cc1ccc2ncccc2c1 InChI=1S/C18H13N3OS2/c22-17-16(24-18(21-17)20-11-14-4-2-8-23-14)10-12-5-6-15-13(9-12)3-1-7-19-15/h1-10H,11H2,(H,20,21,22) XOLMRFUGOINFDQ-UHFFFAOYSA-N 50205472 (5Z)-5-(quinolin-6-ylmethylidene)-2-[(thiophen-2-ylmethyl)amino]-1,3-thiazol-4(5H)-one::(Z)-5-(quinolin-6-ylmethylene)-2-(thiophen-2-ylmethylamino)thiazol-4(5H)-one::CHEMBL261644::CHEMBL393929 Ribosomal protein S6 kinase alpha-3 Homo sapiens >2000 ChEMBL 10.1016/j.bmcl.2007.01.081 10.7270/Q2BV7G9T 17303421 Chen, S; Chen, L; Le, NT; Zhao, C; Sidduri, A; Lou, JP; Michoud, C; Portland, L; Jackson, N; Liu, JJ; Konzelmann, F; Chi, F; Tovar, C; Xiang, Q; Chen, Y; Wen, Y; Vassilev, LT Roche Research Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50205472 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50205472&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 1RO 5O12,4EOI,4EOL,4EON,4EOP,4EOS 11631681 104083820 CHEMBL261644CHEMBL393929 ZINC28821265 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50375352 NC1=NC(=O)C(S1)=Cc1ccc2ncccc2c1 InChI=1S/C13H9N3OS/c14-13-16-12(17)11(18-13)7-8-3-4-10-9(6-8)2-1-5-15-10/h1-7H,(H2,14,16,17) GWSGFSPSQGXVFI-UHFFFAOYSA-N 50205468 (Z)-2-amino-5-(quinolin-6-ylmethylene)thiazol-4(5H)-one::CHEMBL396377 Ribosomal protein S6 kinase alpha-3 Homo sapiens >2000 ChEMBL 10.1016/j.bmcl.2007.01.081 10.7270/Q2BV7G9T 17303421 Chen, S; Chen, L; Le, NT; Zhao, C; Sidduri, A; Lou, JP; Michoud, C; Portland, L; Jackson, N; Liu, JJ; Konzelmann, F; Chi, F; Tovar, C; Xiang, Q; Chen, Y; Wen, Y; Vassilev, LT Roche Research Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50205468 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50205468&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 2337532 104083816 CHEMBL396377 ZINC06189674 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50375367 O=C1N=C(N[C@@H]2C[C@H]2c2ccccc2)SC1=Cc1ccc2ncccc2c1 InChI=1S/C22H17N3OS/c26-21-20(12-14-8-9-18-16(11-14)7-4-10-23-18)27-22(25-21)24-19-13-17(19)15-5-2-1-3-6-15/h1-12,17,19H,13H2,(H,24,25,26)/t17-,19+/m0/s1 FITGAYHGSUWBQP-PKOBYXMFSA-N 50205477 (Z)-2-((1R,2S)-2-phenylcyclopropylamino)-5-(quinolin-6-ylmethylene)thiazol-4(5H)-one::CHEMBL235345 Ribosomal protein S6 kinase alpha-3 Homo sapiens >2000 ChEMBL 10.1016/j.bmcl.2007.01.081 10.7270/Q2BV7G9T 17303421 Chen, S; Chen, L; Le, NT; Zhao, C; Sidduri, A; Lou, JP; Michoud, C; Portland, L; Jackson, N; Liu, JJ; Konzelmann, F; Chi, F; Tovar, C; Xiang, Q; Chen, Y; Wen, Y; Vassilev, LT Roche Research Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50205477 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50205477&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 16739279 104083825 CHEMBL235345 ZINC28821318 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50368199 CNc1nccc(n1)-c1nc([nH]c1-c1cccc(c1)C(F)(F)F)C1CCNCC1 InChI=1S/C20H21F3N6/c1-24-19-26-10-7-15(27-19)17-16(13-3-2-4-14(11-13)20(21,22)23)28-18(29-17)12-5-8-25-9-6-12/h2-4,7,10-12,25H,5-6,8-9H2,1H3,(H,28,29)(H,24,26,27) RHBGODQVOKDULK-UHFFFAOYSA-N 50260228 CHEMBL489344::N-methyl-4-(2-(piperidin-4-yl)-5-(3-(trifluoromethyl)phenyl)-1H-imidazol-4-yl)pyrimidin-2-amine Ribosomal protein S6 kinase alpha-3 Homo sapiens 76000 ChEMBL 10.1074/jbc.M610486200 10.7270/Q2M32VJH 17166835 Quintavalle, M; Sambucini, S; Summa, V; Orsatti, L; Talamo, F; De Francesco, R; Neddermann, P Istituto di Ricerche di Biologia Molecolare "P. Angeletti http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50260228 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50260228&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 11502255 104109983 CHEMBL489344 ZINC45498064 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50368205 CC1CCC(CC1)c1nc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1 InChI=1S/C21H22FN3/c1-14-2-4-17(5-3-14)21-24-19(15-6-8-18(22)9-7-15)20(25-21)16-10-12-23-13-11-16/h6-14,17H,2-5H2,1H3,(H,24,25) RDGQRZYRTFWBJR-UHFFFAOYSA-N 50260229 4-(4-(4-fluorophenyl)-2-(4-methylcyclohexyl)-1H-imidazol-5-yl)pyridine::CHEMBL523938 Ribosomal protein S6 kinase alpha-3 Homo sapiens 39000 ChEMBL 10.1074/jbc.M610486200 10.7270/Q2M32VJH 17166835 Quintavalle, M; Sambucini, S; Summa, V; Orsatti, L; Talamo, F; De Francesco, R; Neddermann, P Istituto di Ricerche di Biologia Molecolare "P. Angeletti http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50260229 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50260229&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 44576212 104109984 CHEMBL523938 ZINC40423395 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50394714 COc1cc(ccc1N)-c1ccc2c(Nc3ccc(cc3NC2=O)C(C)(C)C(=O)Nc2ccc(cc2)N2CCOCC2)c1 InChI=1S/C34H35N5O4/c1-34(2,33(41)36-24-7-9-25(10-8-24)39-14-16-43-17-15-39)23-6-13-28-30(20-23)38-32(40)26-11-4-21(18-29(26)37-28)22-5-12-27(35)31(19-22)42-3/h4-13,18-20,37H,14-17,35H2,1-3H3,(H,36,41)(H,38,40) UWHWQUTVFLDMPJ-UHFFFAOYSA-N 50218709 2-[3-(3-methoxy-4-nitrophenyl)-11-oxo-10,11-dihydro-5Hdibenzo[b,e][1,4]diazepin-8-yl]-2-methyl-N-(4-morpholin-4-ylphenyl)propanamide::CHEMBL389745 Ribosomal protein S6 kinase alpha-3 Homo sapiens >10000 ChEMBL 10.1021/jm070105d 10.7270/Q22J6BKS 17658776 Wang, L; Sullivan, GM; Hexamer, LA; Hasvold, LA; Thalji, R; Przytulinska, M; Tao, ZF; Li, G; Chen, Z; Xiao, Z; Gu, WZ; Xue, J; Bui, MH; Merta, P; Kovar, P; Bouska, JJ; Zhang, H; Park, C; Stewart, KD; Sham, HL; Sowin, TJ; Rosenberg, SH; Lin, NH Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50218709 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50218709&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 44427519 104092268 CHEMBL389745 ZINC28710755 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50393682 CC(C)CCN1[C@H](C)C(=O)N(C)c2cnc(Nc3cc(F)c(O)c(F)c3)nc12 InChI=1S/C19H23F2N5O2/c1-10(2)5-6-26-11(3)18(28)25(4)15-9-22-19(24-17(15)26)23-12-7-13(20)16(27)14(21)8-12/h7-11,27H,5-6H2,1-4H3,(H,22,23,24)/t11-/m1/s1 DTEKTGDVSARYDS-LLVKDONJSA-N 50111373 CHEMBL3604889 Ribosomal protein S6 kinase alpha-3 Homo sapiens 4.0 ChEMBL 10.1021/acs.jmedchem.5b00450 10.7270/Q21C1ZN6 26270416 Jain, R; Mathur, M; Lan, J; Costales, A; Atallah, G; Ramurthy, S; Subramanian, S; Setti, L; Feucht, P; Warne, B; Doyle, L; Basham, S; Jefferson, AB; Lindvall, M; Appleton, BA; Shafer, CM Novartis Institutes for BioMedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50111373 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50111373&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 584 5WIK,5D9K,7N7L 44141269 104005981 CHEMBL3604889 ZINC13440493 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50393683 CC(C)Nc1ncc(-c2cc(F)c(O)c(F)c2)c(n1)-c1ccc(cc1)N1CCN(C)CC1 InChI=1S/C24H27F2N5O/c1-15(2)28-24-27-14-19(17-12-20(25)23(32)21(26)13-17)22(29-24)16-4-6-18(7-5-16)31-10-8-30(3)9-11-31/h4-7,12-15,32H,8-11H2,1-3H3,(H,27,28,29) KDSPNDQAEMFZQR-UHFFFAOYSA-N 50111374 CHEMBL3604888 Ribosomal protein S6 kinase alpha-3 Homo sapiens 20 ChEMBL 10.1021/acs.jmedchem.5b00450 10.7270/Q21C1ZN6 26270416 Jain, R; Mathur, M; Lan, J; Costales, A; Atallah, G; Ramurthy, S; Subramanian, S; Setti, L; Feucht, P; Warne, B; Doyle, L; Basham, S; Jefferson, AB; Lindvall, M; Appleton, BA; Shafer, CM Novartis Institutes for BioMedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50111374 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50111374&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 122186121 104005982 CHEMBL3604888 ZINC13440513 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50393819 CC(C)Nc1ncc(-c2cc(F)c(O)c(F)c2)c(n1)-c1ccc(C)cc1 InChI=1S/C20H19F2N3O/c1-11(2)24-20-23-10-15(14-8-16(21)19(26)17(22)9-14)18(25-20)13-6-4-12(3)5-7-13/h4-11,26H,1-3H3,(H,23,24,25) OEOITLSQKKJYKY-UHFFFAOYSA-N 50111375 CHEMBL3604887 Ribosomal protein S6 kinase alpha-3 Homo sapiens 23 ChEMBL 10.1021/acs.jmedchem.5b00450 10.7270/Q21C1ZN6 26270416 Jain, R; Mathur, M; Lan, J; Costales, A; Atallah, G; Ramurthy, S; Subramanian, S; Setti, L; Feucht, P; Warne, B; Doyle, L; Basham, S; Jefferson, AB; Lindvall, M; Appleton, BA; Shafer, CM Novartis Institutes for BioMedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50111375 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50111375&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 122186120 104005983 CHEMBL3604887 ZINC13440485 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50393820 CNc1ncc(-c2cc(F)c(O)c(F)c2)c(n1)-c1ccc(C)cc1 InChI=1S/C18H15F2N3O/c1-10-3-5-11(6-4-10)16-13(9-22-18(21-2)23-16)12-7-14(19)17(24)15(20)8-12/h3-9,24H,1-2H3,(H,21,22,23) SZXVKXAUZJIMFQ-UHFFFAOYSA-N 50111376 CHEMBL3604886 Ribosomal protein S6 kinase alpha-3 Homo sapiens 13 ChEMBL 10.1021/acs.jmedchem.5b00450 10.7270/Q21C1ZN6 26270416 Jain, R; Mathur, M; Lan, J; Costales, A; Atallah, G; Ramurthy, S; Subramanian, S; Setti, L; Feucht, P; Warne, B; Doyle, L; Basham, S; Jefferson, AB; Lindvall, M; Appleton, BA; Shafer, CM Novartis Institutes for BioMedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50111376 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50111376&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 122186119 104005984 CHEMBL3604886 ZINC13440444 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50393824 Cc1ccc(cc1)-c1nc(N)ncc1-c1cc(F)c(O)c(F)c1 InChI=1S/C17H13F2N3O/c1-9-2-4-10(5-3-9)15-12(8-21-17(20)22-15)11-6-13(18)16(23)14(19)7-11/h2-8,23H,1H3,(H2,20,21,22) HPQKQSNTXXYIDR-UHFFFAOYSA-N 50111377 CHEMBL3604885 Ribosomal protein S6 kinase alpha-3 Homo sapiens 10.0 ChEMBL 10.1021/acs.jmedchem.5b00450 10.7270/Q21C1ZN6 26270416 Jain, R; Mathur, M; Lan, J; Costales, A; Atallah, G; Ramurthy, S; Subramanian, S; Setti, L; Feucht, P; Warne, B; Doyle, L; Basham, S; Jefferson, AB; Lindvall, M; Appleton, BA; Shafer, CM Novartis Institutes for BioMedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50111377 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50111377&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 122186118 104005985 CHEMBL3604885 ZINC13440524 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50393828 CN1CCN(CC1)c1ccc(cc1)-c1cc(Nc2ccc(C)cc2)ncc1-c1cc(F)c(O)c(F)c1 InChI=1S/C29H28F2N4O/c1-19-3-7-22(8-4-19)33-28-17-24(25(18-32-28)21-15-26(30)29(36)27(31)16-21)20-5-9-23(10-6-20)35-13-11-34(2)12-14-35/h3-10,15-18,36H,11-14H2,1-2H3,(H,32,33) PBZUKXQEJRTGRV-UHFFFAOYSA-N 50111378 CHEMBL3604884 Ribosomal protein S6 kinase alpha-3 Homo sapiens 6.0 ChEMBL 10.1021/acs.jmedchem.5b00450 10.7270/Q21C1ZN6 26270416 Jain, R; Mathur, M; Lan, J; Costales, A; Atallah, G; Ramurthy, S; Subramanian, S; Setti, L; Feucht, P; Warne, B; Doyle, L; Basham, S; Jefferson, AB; Lindvall, M; Appleton, BA; Shafer, CM Novartis Institutes for BioMedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50111378 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50111378&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 122186117 104005986 CHEMBL3604884 ZINC36311494 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50393829 CC(C)CNc1cc(-c2ccc(cc2)N2CCN(C)CC2)c(cn1)-c1cc(F)c(O)c(F)c1 InChI=1S/C26H30F2N4O/c1-17(2)15-29-25-14-21(22(16-30-25)19-12-23(27)26(33)24(28)13-19)18-4-6-20(7-5-18)32-10-8-31(3)9-11-32/h4-7,12-14,16-17,33H,8-11,15H2,1-3H3,(H,29,30) RTHBKFCPLFHNBB-UHFFFAOYSA-N 50111379 CHEMBL3604883 Ribosomal protein S6 kinase alpha-3 Homo sapiens 22 ChEMBL 10.1021/acs.jmedchem.5b00450 10.7270/Q21C1ZN6 26270416 Jain, R; Mathur, M; Lan, J; Costales, A; Atallah, G; Ramurthy, S; Subramanian, S; Setti, L; Feucht, P; Warne, B; Doyle, L; Basham, S; Jefferson, AB; Lindvall, M; Appleton, BA; Shafer, CM Novartis Institutes for BioMedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50111379 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50111379&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 122186116 104005987 CHEMBL3604883 ZINC36311485 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50393833 CNc1cc(-c2ccc(cc2)N2CCN(C)CC2)c(cn1)-c1cc(F)c(O)c(F)c1 InChI=1S/C23H24F2N4O/c1-26-22-13-18(19(14-27-22)16-11-20(24)23(30)21(25)12-16)15-3-5-17(6-4-15)29-9-7-28(2)8-10-29/h3-6,11-14,30H,7-10H2,1-2H3,(H,26,27) GIFPFLKKKQLPLV-UHFFFAOYSA-N 50111380 CHEMBL3604882 Ribosomal protein S6 kinase alpha-3 Homo sapiens 14 ChEMBL 10.1021/acs.jmedchem.5b00450 10.7270/Q21C1ZN6 26270416 Jain, R; Mathur, M; Lan, J; Costales, A; Atallah, G; Ramurthy, S; Subramanian, S; Setti, L; Feucht, P; Warne, B; Doyle, L; Basham, S; Jefferson, AB; Lindvall, M; Appleton, BA; Shafer, CM Novartis Institutes for BioMedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50111380 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50111380&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 122186115 104005988 CHEMBL3604882 ZINC13440477 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50393834 CN1CCN(CC1)c1ccc(cc1)-c1cc(N)ncc1-c1cc(F)c(O)c(F)c1 InChI=1S/C22H22F2N4O/c1-27-6-8-28(9-7-27)16-4-2-14(3-5-16)17-12-21(25)26-13-18(17)15-10-19(23)22(29)20(24)11-15/h2-5,10-13,29H,6-9H2,1H3,(H2,25,26) ZPBALWYVPVVNDT-UHFFFAOYSA-N 50111381 CHEMBL3604881 Ribosomal protein S6 kinase alpha-3 Homo sapiens 6.0 ChEMBL 10.1021/acs.jmedchem.5b00450 10.7270/Q21C1ZN6 26270416 Jain, R; Mathur, M; Lan, J; Costales, A; Atallah, G; Ramurthy, S; Subramanian, S; Setti, L; Feucht, P; Warne, B; Doyle, L; Basham, S; Jefferson, AB; Lindvall, M; Appleton, BA; Shafer, CM Novartis Institutes for BioMedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50111381 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50111381&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 122186114 104005989 CHEMBL3604881 ZINC13440505 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50393835 Oc1c(Cl)cc(cc1Cl)-c1cnccc1-c1ccc(F)cc1 InChI=1S/C17H10Cl2FNO/c18-15-7-11(8-16(19)17(15)22)14-9-21-6-5-13(14)10-1-3-12(20)4-2-10/h1-9,22H FWJNKYPUQRBACL-UHFFFAOYSA-N 50111382 CHEMBL3604796 Ribosomal protein S6 kinase alpha-3 Homo sapiens 4800 ChEMBL 10.1021/acs.jmedchem.5b00450 10.7270/Q21C1ZN6 26270416 Jain, R; Mathur, M; Lan, J; Costales, A; Atallah, G; Ramurthy, S; Subramanian, S; Setti, L; Feucht, P; Warne, B; Doyle, L; Basham, S; Jefferson, AB; Lindvall, M; Appleton, BA; Shafer, CM Novartis Institutes for BioMedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50111382 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50111382&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 122186031 104005990 CHEMBL3604796 ZINC13440489 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50393836 COc1ccc(cn1)-c1ccncc1-c1cc(F)c(O)c(F)c1 InChI=1S/C17H12F2N2O2/c1-23-16-3-2-10(8-21-16)12-4-5-20-9-13(12)11-6-14(18)17(22)15(19)7-11/h2-9,22H,1H3 NKBWZEGVHYSODY-UHFFFAOYSA-N 50111383 CHEMBL3604795 Ribosomal protein S6 kinase alpha-3 Homo sapiens 80 ChEMBL 10.1021/acs.jmedchem.5b00450 10.7270/Q21C1ZN6 26270416 Jain, R; Mathur, M; Lan, J; Costales, A; Atallah, G; Ramurthy, S; Subramanian, S; Setti, L; Feucht, P; Warne, B; Doyle, L; Basham, S; Jefferson, AB; Lindvall, M; Appleton, BA; Shafer, CM Novartis Institutes for BioMedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50111383 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50111383&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 122186030 104005991 CHEMBL3604795 ZINC36311487 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50393838 Oc1c(F)cc(cc1F)-c1cnccc1-c1ccc(cc1)N1CCOCC1 InChI=1S/C21H18F2N2O2/c22-19-11-15(12-20(23)21(19)26)18-13-24-6-5-17(18)14-1-3-16(4-2-14)25-7-9-27-10-8-25/h1-6,11-13,26H,7-10H2 YUYJEQHNWKQNBT-UHFFFAOYSA-N 50111384 CHEMBL3604794 Ribosomal protein S6 kinase alpha-3 Homo sapiens 4.0 ChEMBL 10.1021/acs.jmedchem.5b00450 10.7270/Q21C1ZN6 26270416 Jain, R; Mathur, M; Lan, J; Costales, A; Atallah, G; Ramurthy, S; Subramanian, S; Setti, L; Feucht, P; Warne, B; Doyle, L; Basham, S; Jefferson, AB; Lindvall, M; Appleton, BA; Shafer, CM Novartis Institutes for BioMedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50111384 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50111384&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 118704762 104005992 CHEMBL3604794 ZINC13440454 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50393839 CN1CCN(CC1)c1ccc(cc1)-c1ccncc1-c1cc(F)c(O)c(F)c1 InChI=1S/C22H21F2N3O/c1-26-8-10-27(11-9-26)17-4-2-15(3-5-17)18-6-7-25-14-19(18)16-12-20(23)22(28)21(24)13-16/h2-7,12-14,28H,8-11H2,1H3 IKUFKDGKRLMXEX-UHFFFAOYSA-N 50111385 CHEMBL3604793 Ribosomal protein S6 kinase alpha-3 Homo sapiens 5.0 ChEMBL 10.1021/acs.jmedchem.5b00450 10.7270/Q21C1ZN6 26270416 Jain, R; Mathur, M; Lan, J; Costales, A; Atallah, G; Ramurthy, S; Subramanian, S; Setti, L; Feucht, P; Warne, B; Doyle, L; Basham, S; Jefferson, AB; Lindvall, M; Appleton, BA; Shafer, CM Novartis Institutes for BioMedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50111385 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50111385&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 2NK 4NUS 73010393 104005993 CHEMBL3604793 ZINC13440451 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50393843 Oc1c(F)cc(cc1F)-c1cnccc1-c1ccc(cc1)N1CCNCC1 InChI=1S/C21H19F2N3O/c22-19-11-15(12-20(23)21(19)27)18-13-25-6-5-17(18)14-1-3-16(4-2-14)26-9-7-24-8-10-26/h1-6,11-13,24,27H,7-10H2 VAMWJMVATUYTLB-UHFFFAOYSA-N 50111386 CHEMBL3604792 Ribosomal protein S6 kinase alpha-3 Homo sapiens 6.0 ChEMBL 10.1021/acs.jmedchem.5b00450 10.7270/Q21C1ZN6 26270416 Jain, R; Mathur, M; Lan, J; Costales, A; Atallah, G; Ramurthy, S; Subramanian, S; Setti, L; Feucht, P; Warne, B; Doyle, L; Basham, S; Jefferson, AB; Lindvall, M; Appleton, BA; Shafer, CM Novartis Institutes for BioMedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50111386 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50111386&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 122186029 104005994 CHEMBL3604792 ZINC13440465 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50393845 CNC(=O)c1ccc(cc1)-c1ccncc1-c1cc(F)c(O)c(F)c1 InChI=1S/C19H14F2N2O2/c1-22-19(25)12-4-2-11(3-5-12)14-6-7-23-10-15(14)13-8-16(20)18(24)17(21)9-13/h2-10,24H,1H3,(H,22,25) RTECQFROUMPSQG-UHFFFAOYSA-N 50111387 CHEMBL3604791 Ribosomal protein S6 kinase alpha-3 Homo sapiens 20 ChEMBL 10.1021/acs.jmedchem.5b00450 10.7270/Q21C1ZN6 26270416 Jain, R; Mathur, M; Lan, J; Costales, A; Atallah, G; Ramurthy, S; Subramanian, S; Setti, L; Feucht, P; Warne, B; Doyle, L; Basham, S; Jefferson, AB; Lindvall, M; Appleton, BA; Shafer, CM Novartis Institutes for BioMedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50111387 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50111387&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 122186028 104005995 CHEMBL3604791 ZINC13440501 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50393848 COc1ccc(cc1)-c1ccncc1-c1cc(F)c(O)c(F)c1 InChI=1S/C18H13F2NO2/c1-23-13-4-2-11(3-5-13)14-6-7-21-10-15(14)12-8-16(19)18(22)17(20)9-12/h2-10,22H,1H3 LNVRALGTJWRQTK-UHFFFAOYSA-N 50111388 CHEMBL3604790 Ribosomal protein S6 kinase alpha-3 Homo sapiens 8.0 ChEMBL 10.1021/acs.jmedchem.5b00450 10.7270/Q21C1ZN6 26270416 Jain, R; Mathur, M; Lan, J; Costales, A; Atallah, G; Ramurthy, S; Subramanian, S; Setti, L; Feucht, P; Warne, B; Doyle, L; Basham, S; Jefferson, AB; Lindvall, M; Appleton, BA; Shafer, CM Novartis Institutes for BioMedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50111388 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50111388&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 122186027 104005996 CHEMBL3604790 ZINC13440448 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50393850 Cc1ccc(cc1)-c1ccncc1-c1cc(F)c(O)c(F)c1 InChI=1S/C18H13F2NO/c1-11-2-4-12(5-3-11)14-6-7-21-10-15(14)13-8-16(19)18(22)17(20)9-13/h2-10,22H,1H3 UUTIVRONEJLBDK-UHFFFAOYSA-N 50111389 CHEMBL3604789 Ribosomal protein S6 kinase alpha-3 Homo sapiens 7.0 ChEMBL 10.1021/acs.jmedchem.5b00450 10.7270/Q21C1ZN6 26270416 Jain, R; Mathur, M; Lan, J; Costales, A; Atallah, G; Ramurthy, S; Subramanian, S; Setti, L; Feucht, P; Warne, B; Doyle, L; Basham, S; Jefferson, AB; Lindvall, M; Appleton, BA; Shafer, CM Novartis Institutes for BioMedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50111389 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50111389&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 122186026 104005997 CHEMBL3604789 ZINC36311481 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50393856 Oc1c(F)cc(cc1F)-c1cnccc1-c1ccc(F)cc1 InChI=1S/C17H10F3NO/c18-12-3-1-10(2-4-12)13-5-6-21-9-14(13)11-7-15(19)17(22)16(20)8-11/h1-9,22H WEXZHJRBQNKEKT-UHFFFAOYSA-N 50111390 CHEMBL3604788 Ribosomal protein S6 kinase alpha-3 Homo sapiens 94 ChEMBL 10.1021/acs.jmedchem.5b00450 10.7270/Q21C1ZN6 26270416 Jain, R; Mathur, M; Lan, J; Costales, A; Atallah, G; Ramurthy, S; Subramanian, S; Setti, L; Feucht, P; Warne, B; Doyle, L; Basham, S; Jefferson, AB; Lindvall, M; Appleton, BA; Shafer, CM Novartis Institutes for BioMedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50111390 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50111390&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 122186025 104005998 CHEMBL3604788 ZINC13440527 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50393857 CN1CCN(CC1)c1cccc(c1)-c1ccncc1-c1cc(F)c(O)c(F)c1 InChI=1S/C22H21F2N3O/c1-26-7-9-27(10-8-26)17-4-2-3-15(11-17)18-5-6-25-14-19(18)16-12-20(23)22(28)21(24)13-16/h2-6,11-14,28H,7-10H2,1H3 AJGHEMDMZKKTSJ-UHFFFAOYSA-N 50111391 CHEMBL3604787 Ribosomal protein S6 kinase alpha-3 Homo sapiens 4.0 ChEMBL 10.1021/acs.jmedchem.5b00450 10.7270/Q21C1ZN6 26270416 Jain, R; Mathur, M; Lan, J; Costales, A; Atallah, G; Ramurthy, S; Subramanian, S; Setti, L; Feucht, P; Warne, B; Doyle, L; Basham, S; Jefferson, AB; Lindvall, M; Appleton, BA; Shafer, CM Novartis Institutes for BioMedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50111391 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50111391&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 122186024 104005999 CHEMBL3604787 ZINC13440473 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50393858 Oc1c(F)cc(cc1F)-c1cnccc1-c1cccc(c1)N1CCOCC1 InChI=1S/C21H18F2N2O2/c22-19-11-15(12-20(23)21(19)26)18-13-24-5-4-17(18)14-2-1-3-16(10-14)25-6-8-27-9-7-25/h1-5,10-13,26H,6-9H2 JXGRDWXLVXGFGC-UHFFFAOYSA-N 50111392 CHEMBL3604786 Ribosomal protein S6 kinase alpha-3 Homo sapiens 18 ChEMBL 10.1021/acs.jmedchem.5b00450 10.7270/Q21C1ZN6 26270416 Jain, R; Mathur, M; Lan, J; Costales, A; Atallah, G; Ramurthy, S; Subramanian, S; Setti, L; Feucht, P; Warne, B; Doyle, L; Basham, S; Jefferson, AB; Lindvall, M; Appleton, BA; Shafer, CM Novartis Institutes for BioMedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50111392 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50111392&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 122186023 104006000 CHEMBL3604786 ZINC13440509 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50393859 Oc1c(F)cc(cc1F)-c1cnccc1-c1cccc(c1)-c1cn[nH]c1 InChI=1S/C20H13F2N3O/c21-18-7-14(8-19(22)20(18)26)17-11-23-5-4-16(17)13-3-1-2-12(6-13)15-9-24-25-10-15/h1-11,26H,(H,24,25) SKGOKFXHVKRTIW-UHFFFAOYSA-N 50111393 CHEMBL3604785 Ribosomal protein S6 kinase alpha-3 Homo sapiens 5.0 ChEMBL 10.1021/acs.jmedchem.5b00450 10.7270/Q21C1ZN6 26270416 Jain, R; Mathur, M; Lan, J; Costales, A; Atallah, G; Ramurthy, S; Subramanian, S; Setti, L; Feucht, P; Warne, B; Doyle, L; Basham, S; Jefferson, AB; Lindvall, M; Appleton, BA; Shafer, CM Novartis Institutes for BioMedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50111393 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50111393&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 122186022 104006001 CHEMBL3604785 ZINC13440481 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50393860 NCCOc1cccc(c1)-c1ccncc1-c1cc(F)c(O)c(F)c1 InChI=1S/C19H16F2N2O2/c20-17-9-13(10-18(21)19(17)24)16-11-23-6-4-15(16)12-2-1-3-14(8-12)25-7-5-22/h1-4,6,8-11,24H,5,7,22H2 SRNVWQXDZWXKFC-UHFFFAOYSA-N 50111394 CHEMBL3604784 Ribosomal protein S6 kinase alpha-3 Homo sapiens 4.0 ChEMBL 10.1021/acs.jmedchem.5b00450 10.7270/Q21C1ZN6 26270416 Jain, R; Mathur, M; Lan, J; Costales, A; Atallah, G; Ramurthy, S; Subramanian, S; Setti, L; Feucht, P; Warne, B; Doyle, L; Basham, S; Jefferson, AB; Lindvall, M; Appleton, BA; Shafer, CM Novartis Institutes for BioMedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50111394 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50111394&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 122186021 104006002 CHEMBL3604784 ZINC13440543 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50393861 COc1cccc(c1)-c1ccncc1-c1cc(F)c(O)c(F)c1 InChI=1S/C18H13F2NO2/c1-23-13-4-2-3-11(7-13)14-5-6-21-10-15(14)12-8-16(19)18(22)17(20)9-12/h2-10,22H,1H3 CZIQZFRYLZOTAU-UHFFFAOYSA-N 50111395 CHEMBL3604783 Ribosomal protein S6 kinase alpha-3 Homo sapiens 46 ChEMBL 10.1021/acs.jmedchem.5b00450 10.7270/Q21C1ZN6 26270416 Jain, R; Mathur, M; Lan, J; Costales, A; Atallah, G; Ramurthy, S; Subramanian, S; Setti, L; Feucht, P; Warne, B; Doyle, L; Basham, S; Jefferson, AB; Lindvall, M; Appleton, BA; Shafer, CM Novartis Institutes for BioMedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50111395 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50111395&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 122186020 104006003 CHEMBL3604783 ZINC13440497 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50393862 Cc1cccc(c1)-c1ccncc1-c1cc(F)c(O)c(F)c1 InChI=1S/C18H13F2NO/c1-11-3-2-4-12(7-11)14-5-6-21-10-15(14)13-8-16(19)18(22)17(20)9-13/h2-10,22H,1H3 RXJKIHBSKCIXKE-UHFFFAOYSA-N 50111361 CHEMBL3604782 Ribosomal protein S6 kinase alpha-3 Homo sapiens 32 ChEMBL 10.1021/acs.jmedchem.5b00450 10.7270/Q21C1ZN6 26270416 Jain, R; Mathur, M; Lan, J; Costales, A; Atallah, G; Ramurthy, S; Subramanian, S; Setti, L; Feucht, P; Warne, B; Doyle, L; Basham, S; Jefferson, AB; Lindvall, M; Appleton, BA; Shafer, CM Novartis Institutes for BioMedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50111361 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50111361&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 122186019 319493382 CHEMBL3604782 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50393863 CC(C)c1ccncc1-c1cc(F)c(O)c(F)c1 InChI=1S/C14H13F2NO/c1-8(2)10-3-4-17-7-11(10)9-5-12(15)14(18)13(16)6-9/h3-8,18H,1-2H3 HRIBPTNPPPEBMO-UHFFFAOYSA-N 50111362 CHEMBL3604781 Ribosomal protein S6 kinase alpha-3 Homo sapiens 780 ChEMBL 10.1021/acs.jmedchem.5b00450 10.7270/Q21C1ZN6 26270416 Jain, R; Mathur, M; Lan, J; Costales, A; Atallah, G; Ramurthy, S; Subramanian, S; Setti, L; Feucht, P; Warne, B; Doyle, L; Basham, S; Jefferson, AB; Lindvall, M; Appleton, BA; Shafer, CM Novartis Institutes for BioMedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50111362 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50111362&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 122186018 319493383 CHEMBL3604781 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50393864 Oc1c(F)cc(cc1F)-c1cnccc1C1CCNCC1 InChI=1S/C16H16F2N2O/c17-14-7-11(8-15(18)16(14)21)13-9-20-6-3-12(13)10-1-4-19-5-2-10/h3,6-10,19,21H,1-2,4-5H2 OGRWLDHVLHSNOM-UHFFFAOYSA-N 50111363 CHEMBL3604780 Ribosomal protein S6 kinase alpha-3 Homo sapiens 2100 ChEMBL 10.1021/acs.jmedchem.5b00450 10.7270/Q21C1ZN6 26270416 Jain, R; Mathur, M; Lan, J; Costales, A; Atallah, G; Ramurthy, S; Subramanian, S; Setti, L; Feucht, P; Warne, B; Doyle, L; Basham, S; Jefferson, AB; Lindvall, M; Appleton, BA; Shafer, CM Novartis Institutes for BioMedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50111363 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50111363&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 122186017 319493384 CHEMBL3604780 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50393865 Oc1c(F)cc(cc1F)-c1cnccc1C1CCOCC1 InChI=1S/C16H15F2NO2/c17-14-7-11(8-15(18)16(14)20)13-9-19-4-1-12(13)10-2-5-21-6-3-10/h1,4,7-10,20H,2-3,5-6H2 VACMZWAHKWHHMN-UHFFFAOYSA-N 50111364 CHEMBL3604779 Ribosomal protein S6 kinase alpha-3 Homo sapiens 130 ChEMBL 10.1021/acs.jmedchem.5b00450 10.7270/Q21C1ZN6 26270416 Jain, R; Mathur, M; Lan, J; Costales, A; Atallah, G; Ramurthy, S; Subramanian, S; Setti, L; Feucht, P; Warne, B; Doyle, L; Basham, S; Jefferson, AB; Lindvall, M; Appleton, BA; Shafer, CM Novartis Institutes for BioMedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50111364 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50111364&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 122186016 319493385 CHEMBL3604779 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50393866 Oc1c(F)cc(cc1F)-c1cnccc1-c1ccccc1 InChI=1S/C17H11F2NO/c18-15-8-12(9-16(19)17(15)21)14-10-20-7-6-13(14)11-4-2-1-3-5-11/h1-10,21H WQBTWNKSFDRALJ-UHFFFAOYSA-N 50111365 CHEMBL3604778 Ribosomal protein S6 kinase alpha-3 Homo sapiens 60 ChEMBL 10.1021/acs.jmedchem.5b00450 10.7270/Q21C1ZN6 26270416 Jain, R; Mathur, M; Lan, J; Costales, A; Atallah, G; Ramurthy, S; Subramanian, S; Setti, L; Feucht, P; Warne, B; Doyle, L; Basham, S; Jefferson, AB; Lindvall, M; Appleton, BA; Shafer, CM Novartis Institutes for BioMedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50111365 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50111365&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 122186015 319493386 CHEMBL3604778 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50393867 Oc1ccc(cc1)-c1ccncc1-c1cc(F)c(O)c(F)c1 InChI=1S/C17H11F2NO2/c18-15-7-11(8-16(19)17(15)22)14-9-20-6-5-13(14)10-1-3-12(21)4-2-10/h1-9,21-22H VTDTXABIZXUXME-UHFFFAOYSA-N 50111366 CHEMBL3604777 Ribosomal protein S6 kinase alpha-3 Homo sapiens 50 ChEMBL 10.1021/acs.jmedchem.5b00450 10.7270/Q21C1ZN6 26270416 Jain, R; Mathur, M; Lan, J; Costales, A; Atallah, G; Ramurthy, S; Subramanian, S; Setti, L; Feucht, P; Warne, B; Doyle, L; Basham, S; Jefferson, AB; Lindvall, M; Appleton, BA; Shafer, CM Novartis Institutes for BioMedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50111366 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50111366&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 122186014 319493387 CHEMBL3604777 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50393868 Oc1ccc(cc1)-c1ccncc1-c1ccc(O)cc1 InChI=1S/C17H13NO2/c19-14-5-1-12(2-6-14)16-9-10-18-11-17(16)13-3-7-15(20)8-4-13/h1-11,19-20H FTUOTWYRSQTGOK-UHFFFAOYSA-N 50111367 CHEMBL3604776 Ribosomal protein S6 kinase alpha-3 Homo sapiens 180 ChEMBL 10.1021/acs.jmedchem.5b00450 10.7270/Q21C1ZN6 26270416 Jain, R; Mathur, M; Lan, J; Costales, A; Atallah, G; Ramurthy, S; Subramanian, S; Setti, L; Feucht, P; Warne, B; Doyle, L; Basham, S; Jefferson, AB; Lindvall, M; Appleton, BA; Shafer, CM Novartis Institutes for BioMedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50111367 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50111367&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 122186013 319493388 CHEMBL3604776 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50393869 Oc1ccc(cc1)-c1cn[nH]c1-c1cc(F)c(O)c(F)c1 InChI=1S/C15H10F2N2O2/c16-12-5-9(6-13(17)15(12)21)14-11(7-18-19-14)8-1-3-10(20)4-2-8/h1-7,20-21H,(H,18,19) LKJIWFIGQMHDPR-UHFFFAOYSA-N 50111368 CHEMBL3604775 Ribosomal protein S6 kinase alpha-3 Homo sapiens 6.0 ChEMBL 10.1021/acs.jmedchem.5b00450 10.7270/Q21C1ZN6 26270416 Jain, R; Mathur, M; Lan, J; Costales, A; Atallah, G; Ramurthy, S; Subramanian, S; Setti, L; Feucht, P; Warne, B; Doyle, L; Basham, S; Jefferson, AB; Lindvall, M; Appleton, BA; Shafer, CM Novartis Institutes for BioMedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50111368 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50111368&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 122186012 104005976 CHEMBL3604775 ZINC13440537 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50393870 Nc1n[nH]c(c1-c1ccccc1)-c1ccc(O)cc1 InChI=1S/C15H13N3O/c16-15-13(10-4-2-1-3-5-10)14(17-18-15)11-6-8-12(19)9-7-11/h1-9,19H,(H3,16,17,18) HSHRVAFOSVHQNQ-UHFFFAOYSA-N 50111369 CHEMBL3604774 Ribosomal protein S6 kinase alpha-3 Homo sapiens 53 ChEMBL 10.1021/acs.jmedchem.5b00450 10.7270/Q21C1ZN6 26270416 Jain, R; Mathur, M; Lan, J; Costales, A; Atallah, G; Ramurthy, S; Subramanian, S; Setti, L; Feucht, P; Warne, B; Doyle, L; Basham, S; Jefferson, AB; Lindvall, M; Appleton, BA; Shafer, CM Novartis Institutes for BioMedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50111369 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50111369&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 122186011 104005977 CHEMBL3604774 ZINC13440446 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50393871 Oc1ccc(cc1)-c1cn[nH]c1-c1ccccc1 InChI=1S/C15H12N2O/c18-13-8-6-11(7-9-13)14-10-16-17-15(14)12-4-2-1-3-5-12/h1-10,18H,(H,16,17) NKCQURNGRKMMNF-UHFFFAOYSA-N 50111370 CHEMBL3604773 Ribosomal protein S6 kinase alpha-3 Homo sapiens 2500 ChEMBL 10.1021/acs.jmedchem.5b00450 10.7270/Q21C1ZN6 26270416 Jain, R; Mathur, M; Lan, J; Costales, A; Atallah, G; Ramurthy, S; Subramanian, S; Setti, L; Feucht, P; Warne, B; Doyle, L; Basham, S; Jefferson, AB; Lindvall, M; Appleton, BA; Shafer, CM Novartis Institutes for BioMedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50111370 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50111370&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 39222210 104005978 CHEMBL3604773 ZINC13440469 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50393872 Oc1ccc(cc1)-c1[nH]ncc1-c1ccccc1 InChI=1S/C15H12N2O/c18-13-8-6-12(7-9-13)15-14(10-16-17-15)11-4-2-1-3-5-11/h1-10,18H,(H,16,17) RYNUCFRWRKDYTQ-UHFFFAOYSA-N 50111371 CHEMBL3604772 Ribosomal protein S6 kinase alpha-3 Homo sapiens 150 ChEMBL 10.1021/acs.jmedchem.5b00450 10.7270/Q21C1ZN6 26270416 Jain, R; Mathur, M; Lan, J; Costales, A; Atallah, G; Ramurthy, S; Subramanian, S; Setti, L; Feucht, P; Warne, B; Doyle, L; Basham, S; Jefferson, AB; Lindvall, M; Appleton, BA; Shafer, CM Novartis Institutes for BioMedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50111371 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50111371&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 57014788 104005979 CHEMBL3604772 ZINC13440518 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50393873 Oc1ccc(cc1)-c1cn[nH]c1-c1ccc(O)cc1 InChI=1S/C15H12N2O2/c18-12-5-1-10(2-6-12)14-9-16-17-15(14)11-3-7-13(19)8-4-11/h1-9,18-19H,(H,16,17) FHGTUVGVZRNUDB-UHFFFAOYSA-N 50111372 CHEMBL3604771 Ribosomal protein S6 kinase alpha-3 Homo sapiens 24 ChEMBL 10.1021/acs.jmedchem.5b00450 10.7270/Q21C1ZN6 26270416 Jain, R; Mathur, M; Lan, J; Costales, A; Atallah, G; Ramurthy, S; Subramanian, S; Setti, L; Feucht, P; Warne, B; Doyle, L; Basham, S; Jefferson, AB; Lindvall, M; Appleton, BA; Shafer, CM Novartis Institutes for BioMedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50111372 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50111372&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 91844463 104005980 CHEMBL3604771 ZINC13440462 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50447763 Cn1c2nc(Nc3ccc4[nH]ccc4c3)ncc2cc(c1=O)S(=O)(=O)c1ccc(F)cc1F InChI=1S/C22H15F2N5O3S/c1-29-20-13(9-19(21(29)30)33(31,32)18-5-2-14(23)10-16(18)24)11-26-22(28-20)27-15-3-4-17-12(8-15)6-7-25-17/h2-11,25H,1H3,(H,26,27,28) ZEHBZHZMQSHZFI-UHFFFAOYSA-N 50135286 CHEMBL3745885 Ribosomal protein S6 kinase alpha-3 Homo sapiens >10000 ChEMBL 10.1016/j.bmc.2015.11.045 10.7270/Q24Q7WT8 26762835 Reddy, MV; Akula, B; Jatiani, S; Vasquez-Del Carpio, R; Billa, VK; Mallireddigari, MR; Cosenza, SC; Venkata Subbaiah, DR; Bharathi, EV; Pallela, VR; Ramkumar, P; Jain, R; Aggarwal, AK; Reddy, EP Icahn School of Medicine at Mount Sinai http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50135286 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50135286&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 67240318 336951802 CHEMBL3745885 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50546332 NCCn1cc(-c2cc(-c3cc4ccccc4s3)c3[nH]ncc3c2)c2nc(N)ncc12 InChI=1S/C23H19N7S/c24-5-6-30-12-17(22-18(30)11-26-23(25)28-22)14-7-15-10-27-29-21(15)16(8-14)20-9-13-3-1-2-4-19(13)31-20/h1-4,7-12H,5-6,24H2,(H,27,29)(H2,25,26,28) JPOSFPUHBHRUAX-UHFFFAOYSA-N 50305006 5-(2-aminoethyl)-7-(7-(benzo[b]thiophen-2-yl)-1H-indazol-5-yl)-5H-pyrrolo[3,2-d]pyrimidin-2-amine::CHEMBL590109 Ribosomal protein S6 kinase alpha-3 Homo sapiens 4000 ChEMBL 10.1016/j.bmcl.2009.10.103 10.7270/Q2VD6ZJJ 19926477 Harris, CM; Ericsson, AM; Argiriadi, MA; Barberis, C; Borhani, DW; Burchat, A; Calderwood, DJ; Cunha, GA; Dixon, RW; Frank, KE; Johnson, EF; Kamens, J; Kwak, S; Li, B; Mullen, KD; Perron, DC; Wang, L; Wishart, N; Wu, X; Zhang, X; Zmetra, TR; Talanian, RV Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50305006 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50305006&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 46224684 104159367 CHEMBL590109 ZINC45335993 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50604834 C[C@@H](N1C[C@H](C)O[C@H](C)C1)c1cc(Nc2nc(C)cn3c(cnc23)-c2cn[nH]c2)sn1 InChI=1S/C21H26N8OS/c1-12-9-29-18(16-6-23-24-7-16)8-22-21(29)20(25-12)26-19-5-17(27-31-19)15(4)28-10-13(2)30-14(3)11-28/h5-9,13-15H,10-11H2,1-4H3,(H,23,24)(H,25,26)/t13-,14+,15-/m1/s1 QBWKPGNFQQJGFY-QLFBSQMISA-N 50329197 3-((R)-1-((2S,6R)-2,6-dimethylmorpholino)ethyl)-N-(6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl)isothiazol-5-amine::CHEMBL1270399 Ribosomal protein S6 kinase alpha-3 Homo sapiens 330 ChEMBL 10.1016/j.bmcl.2010.08.140 10.7270/Q2K074HX 20855207 Belanger, DB; Williams, MJ; Curran, PJ; Mandal, AK; Meng, Z; Rainka, MP; Yu, T; Shih, NY; Siddiqui, MA; Liu, M; Tevar, S; Lee, S; Liang, L; Gray, K; Yaremko, B; Jones, J; Smith, EB; Prelusky, DB; Basso, AD Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50329197 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50329197&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 46868971 123108312 CHEMBL1270399 ZINC64513912 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50604850 CCN(Cc1cc(Nc2nc(C)cn3c(cnc23)-c2cn[nH]c2)sn1)C(C)(C)CO InChI=1S/C20H26N8OS/c1-5-27(20(3,4)12-29)11-15-6-17(30-26-15)25-18-19-21-9-16(14-7-22-23-8-14)28(19)10-13(2)24-18/h6-10,29H,5,11-12H2,1-4H3,(H,22,23)(H,24,25) RHGZQGXELRMGES-UHFFFAOYSA-N 50329198 2-(ethyl((5-(6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-ylamino)isothiazol-3-yl)methyl)amino)-2-methylpropan-1-ol::2-{ethyl[(5-{[6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]amino}isothiazol-3-yl)methyl]amino}-2-methylpropan-1-ol::CHEMBL1232515::CHEMBL1650533 Ribosomal protein S6 kinase alpha-3 Homo sapiens 180 ChEMBL 10.1016/j.bmcl.2010.08.140 10.7270/Q2K074HX 20855207 Belanger, DB; Williams, MJ; Curran, PJ; Mandal, AK; Meng, Z; Rainka, MP; Yu, T; Shih, NY; Siddiqui, MA; Liu, M; Tevar, S; Lee, S; Liang, L; Gray, K; Yaremko, B; Jones, J; Smith, EB; Prelusky, DB; Basso, AD Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50329198 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50329198&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search EML 3MYG 25144732 123108313 CHEMBL1232515CHEMBL1650533 ZINC58660958 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50595727 COc1cc2c(ncnc2cc1OCCCN1CCCCC1)N1CCN(CC1)C(=O)Nc1ccc(OC(C)C)cc1 InChI=1S/C31H42N6O4/c1-23(2)41-25-10-8-24(9-11-25)34-31(38)37-17-15-36(16-18-37)30-26-20-28(39-3)29(21-27(26)32-22-33-30)40-19-7-14-35-12-5-4-6-13-35/h8-11,20-23H,4-7,12-19H2,1-3H3,(H,34,38) UXXQOJXBIDBUAC-UHFFFAOYSA-N 13535 4-[6-methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin-4-yl]-N-(4-propan-2-yloxyphenyl)piperazine-1-carboxamide::4-[6-methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin-4-yl]-N-[4-(1-methylethoxy)phenyl]piperazine-1-carboxamide::4-[6-methoxy-7-[3-(1-piperidinyl)propoxy]-4-quinazolinyl]-N-(4-propan-2-yloxyphenyl)-1-piperazinecarboxamide::4-{6-methoxy-7-[3-(piperidin-1-yl)propoxy]quinazolin-4-yl}-N-[4-(propan-2-yloxy)phenyl]piperazine-1-carboxamide::CHEMBL124660::MLN-518::MLN518::N-(4-isopropoxyphenyl)-4-[6-methoxy-7-(3-piperidinopropoxy)quinazolin-4-yl]piperazine-1-carboxamide::cid_3038522 Ribosomal protein S6 kinase alpha-3 Homo sapiens >10000 ChEMBL 10.1182/blood-2009-05-222034 10.7270/Q2PN95V2 19654408 Zarrinkar, PP; Gunawardane, RN; Cramer, MD; Gardner, MF; Brigham, D; Belli, B; Karaman, MW; Pratz, KW; Pallares, G; Chao, Q; Sprankle, KG; Patel, HK; Levis, M; Armstrong, RC; James, J; Bhagwat, SS Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13535 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13535&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 3038522 46513936 CHEMBL124660 DB05465 ZINC03966243 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50596000 CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)cc2)ccn1 InChI=1S/C21H16ClF3N4O3/c1-26-19(30)18-11-15(8-9-27-18)32-14-5-2-12(3-6-14)28-20(31)29-13-4-7-17(22)16(10-13)21(23,24)25/h2-11H,1H3,(H,26,30)(H2,28,29,31) MLDQJTXFUGDVEO-UHFFFAOYSA-N 16673 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)phenoxy]-N-methylpyridine-2-carboxamide::4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methyl-picolinamide;tosylic acid::BAY 43-9006::BAY 439006::BAY439006::CHEMBL1336::Hit compound, 8::Nexavar::Sorafenib::Sorafenib, 4::US10183928, Sorafenib::US10202365, Compound Sorafenib::US10227329, Compound Sorafenib::US10584114, Compound Sorafenib::US10774070, Compound Sorafenib::US10980809, Example Sorafenib::US11279688, Compound Sorafenib::US11505527, Compound Sorafenib::US9029401, Sorafenib::US9469639, Sorafenib::US9902709, Comparative example 1::Xarelto::cid_216239 Ribosomal protein S6 kinase alpha-3 Homo sapiens >10000 ChEMBL 10.1182/blood-2009-05-222034 10.7270/Q2PN95V2 19654408 Zarrinkar, PP; Gunawardane, RN; Cramer, MD; Gardner, MF; Brigham, D; Belli, B; Karaman, MW; Pratz, KW; Pallares, G; Chao, Q; Sprankle, KG; Patel, HK; Levis, M; Armstrong, RC; James, J; Bhagwat, SS Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=16673 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=16673&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search BAX 3GCS,4ASD,3WZE,5HI2,3HEG,1UWH,1UWJ,3RGF 216239 46516901 50924 CHEMBL1336 DB00398 5711 ZINC01493878 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50594982 CC(C)(C)c1cc(NC(=O)Nc2ccc(cc2)-c2cn3c(n2)sc2cc(OCCN4CCOCC4)ccc32)no1 InChI=1S/C29H32N6O4S/c1-29(2,3)25-17-26(33-39-25)32-27(36)30-20-6-4-19(5-7-20)22-18-35-23-9-8-21(16-24(23)40-28(35)31-22)38-15-12-34-10-13-37-14-11-34/h4-9,16-18H,10-15H2,1-3H3,(H2,30,32,33,36) CVWXJKQAOSCOAB-UHFFFAOYSA-N 50300690 1-(5-Tert-Butyl-1,2-Oxazol-3-Yl)-3-(4-{7-[2-(Morpholin-4-Yl)ethoxy]imidazo[2,1-B][1,3]benzothiazol-2-Yl}phenyl)urea::AC 010220::AC 220::AC-220::AC010220::AC220::ASP-2689::CHEMBL576982::N-(5-tert-Butyl-isoxazol-3-yl)-N'-{4-[7-(2-morpholin-4-yl-ethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea::Quizartinib::Quizartinib (AC220)::US10266535, Compound AC220::US11542261, Compound quizartinib::US9216997, Quizartinib (positive compound) Ribosomal protein S6 kinase alpha-3 Homo sapiens >10000 ChEMBL 10.1182/blood-2009-05-222034 10.7270/Q2PN95V2 19654408 Zarrinkar, PP; Gunawardane, RN; Cramer, MD; Gardner, MF; Brigham, D; Belli, B; Karaman, MW; Pratz, KW; Pallares, G; Chao, Q; Sprankle, KG; Patel, HK; Levis, M; Armstrong, RC; James, J; Bhagwat, SS Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50300690 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50300690&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search P30 4XUF,4RT7 24889392 104155051 CHEMBL576982 5658 ZINC43204002 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50591781 Cc1ccc(cc1)-c1c(C(=O)CF)n(CCCO)c2ncnc(N)c12 InChI=1S/C18H19FN4O2/c1-11-3-5-12(6-4-11)14-15-17(20)21-10-22-18(15)23(7-2-8-24)16(14)13(25)9-19/h3-6,10,24H,2,7-9H2,1H3,(H2,20,21,22) IKLGYJACVCXYIL-UHFFFAOYSA-N 50248765 1-(4-amino-7-(3-hydroxypropyl)-5-p-tolyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl)-2-fluoroethanone::CHEMBL515414 Ribosomal protein S6 kinase alpha-3 Homo sapiens 15 ChEMBL 10.1038/nchembio859 10.7270/Q22B8Z60 17259979 Cohen, MS; Hadjivassiliou, H; Taunton, J University of California http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50248765 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50248765&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 644243 104103317 CHEMBL515414 ZINC06718642 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50591782 C[C+]1C=C(C)C2=Cc3ccc(CCC(=O)NCCCCCC(=O)NCCCCNC(=O)OCCCn4c(C(=O)CF)c(-c5ccc(C)cc5)c5c(N)ncnc45)n3[B-](F)(F)C12 InChI=1S/C44H54BF3N8O5/c1-28-11-13-31(14-12-28)38-39-42(49)53-27-54-43(39)55(41(38)35(57)26-46)22-9-23-61-44(60)52-21-8-7-20-50-36(58)10-5-4-6-19-51-37(59)18-17-32-15-16-33-25-34-29(2)24-30(3)40(34)45(47,48)56(32)33/h11-16,24-25,27,40H,4-10,17-23,26H2,1-3H3,(H,50,58)(H,51,59)(H,52,60)(H2,49,53,54) DUYBUSXUFJRCHK-UHFFFAOYSA-N 50324684 3-(1-(4-amino-6-(2-fluoroacetyl)-5-p-tolyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5,12,19-trioxo-4-oxa-6,11,18-triazahenicosan-21-yl)-5,5-difluoro-6,8-dimethyl-5,5a-dihydrocyclopenta[c]pyrrolo[1,2-f][1,2]azaborinin-4-ium-5-uide::CHEMBL1221656 Ribosomal protein S6 kinase alpha-3 Homo sapiens 1700 ChEMBL 10.1038/nchembio859 10.7270/Q22B8Z60 17259979 Cohen, MS; Hadjivassiliou, H; Taunton, J University of California http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50324684 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50324684&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 49864389 117646005 CHEMBL1221656 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50591783 Cc1ccc(cc1)-c1c(C(=O)CF)n(CCCNCC#N)c2ncnc(N)c12 InChI=1S/C20H21FN6O/c1-13-3-5-14(6-4-13)16-17-19(23)25-12-26-20(17)27(18(16)15(28)11-21)10-2-8-24-9-7-22/h3-6,12,24H,2,8-11H2,1H3,(H2,23,25,26) CCURGKYXBXHODK-UHFFFAOYSA-N 50324685 2-(3-(4-amino-6-(2-fluoroacetyl)-5-p-tolyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)propylamino)acetonitrile::CHEMBL1221698 Ribosomal protein S6 kinase alpha-3 Homo sapiens 20 ChEMBL 10.1038/nchembio859 10.7270/Q22B8Z60 17259979 Cohen, MS; Hadjivassiliou, H; Taunton, J University of California http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50324685 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50324685&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 49864404 117646006 CHEMBL1221698 ZINC58639057 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50591784 Cc1ccc(cc1)-c1c(C(=O)CF)n(CCCO)c2ncnc(N)c12 InChI=1S/C18H19FN4O2/c1-11-3-5-12(6-4-11)14-15-17(20)21-10-22-18(15)23(7-2-8-24)16(14)13(25)9-19/h3-6,10,24H,2,7-9H2,1H3,(H2,20,21,22) IKLGYJACVCXYIL-UHFFFAOYSA-N 50248765 1-(4-amino-7-(3-hydroxypropyl)-5-p-tolyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl)-2-fluoroethanone::CHEMBL515414 Ribosomal protein S6 kinase alpha-3 Homo sapiens 150 ChEMBL 10.1038/nchembio859 10.7270/Q22B8Z60 17259979 Cohen, MS; Hadjivassiliou, H; Taunton, J University of California http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50248765 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50248765&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 644243 104103317 CHEMBL515414 ZINC06718642 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50591785 C[C+]1C=C(C)C2=Cc3ccc(CCC(=O)NCCCCCC(=O)NCCCCNC(=O)OCCCn4c(C(=O)CF)c(-c5ccc(C)cc5)c5c(N)ncnc45)n3[B-](F)(F)C12 InChI=1S/C44H54BF3N8O5/c1-28-11-13-31(14-12-28)38-39-42(49)53-27-54-43(39)55(41(38)35(57)26-46)22-9-23-61-44(60)52-21-8-7-20-50-36(58)10-5-4-6-19-51-37(59)18-17-32-15-16-33-25-34-29(2)24-30(3)40(34)45(47,48)56(32)33/h11-16,24-25,27,40H,4-10,17-23,26H2,1-3H3,(H,50,58)(H,51,59)(H,52,60)(H2,49,53,54) DUYBUSXUFJRCHK-UHFFFAOYSA-N 50324684 3-(1-(4-amino-6-(2-fluoroacetyl)-5-p-tolyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5,12,19-trioxo-4-oxa-6,11,18-triazahenicosan-21-yl)-5,5-difluoro-6,8-dimethyl-5,5a-dihydrocyclopenta[c]pyrrolo[1,2-f][1,2]azaborinin-4-ium-5-uide::CHEMBL1221656 Ribosomal protein S6 kinase alpha-3 Homo sapiens 10000 ChEMBL 10.1038/nchembio859 10.7270/Q22B8Z60 17259979 Cohen, MS; Hadjivassiliou, H; Taunton, J University of California http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50324684 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50324684&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 49864389 117646005 CHEMBL1221656 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50596834 CCN(CC)CCNC(=O)c1c(C)[nH]c(\C=C2/C(=O)Nc3ccc(F)cc23)c1C InChI=1S/C22H27FN4O2/c1-5-27(6-2)10-9-24-22(29)20-13(3)19(25-14(20)4)12-17-16-11-15(23)7-8-18(16)26-21(17)28/h7-8,11-12,25H,5-6,9-10H2,1-4H3,(H,24,29)(H,26,28)/b17-12- WINHZLLDWRZWRT-ATVHPVEESA-N 4814 CHEMBL535::N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide::N-[2-(diethylamino)ethyl]-5-{[(3Z)-5-fluoro-2-oxo-2,3-dihydro-1H-indol-3-ylidene]methyl}-2,4-dimethyl-1H-pyrrole-3-carboxamide::SU11248::SUNITINIB::SUNITINIB MALATE::US10464902, Sunitinib::US9163010, Sunitinib::US9914707, SU11248 Ribosomal protein S6 kinase alpha-3 Homo sapiens 2000 ChEMBL 10.1182/blood-2009-05-222034 10.7270/Q2PN95V2 19654408 Zarrinkar, PP; Gunawardane, RN; Cramer, MD; Gardner, MF; Brigham, D; Belli, B; Karaman, MW; Pratz, KW; Pallares, G; Chao, Q; Sprankle, KG; Patel, HK; Levis, M; Armstrong, RC; James, J; Bhagwat, SS Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=4814 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=4814&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search B49 6NG0,4KS8,3G0F,3G0E,2Y7J,6JOK,6M11,3MIY,3TI1,4QMZ,6V0X,6NFZ,6NFY,4AGD 5329102 8034462 38940 CHEMBL535 DB01268 5713 ZINC03964325 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50595279 CO[C@@H]1[C@@H](C[C@H]2O[C@]1(C)n1c3ccccc3c3c4[C@H](O)NC(=O)c4c4c5ccccc5n2c4c13)N(C)C(=O)c1ccccc1 InChI=1S/C35H30N4O5/c1-35-31(43-3)23(37(2)34(42)18-11-5-4-6-12-18)17-24(44-35)38-21-15-9-7-13-19(21)25-27-28(33(41)36-32(27)40)26-20-14-8-10-16-22(20)39(35)30(26)29(25)38/h4-16,23-24,31,33,41H,17H2,1-3H3,(H,36,40)/t23-,24-,31-,33+,35+/m1/s1 ZZSBPGIGIUFJRA-AKIDMACVSA-N 50326054 CHEMBL1240703 Ribosomal protein S6 kinase alpha-3 Homo sapiens >10000 ChEMBL 10.1182/blood-2009-05-222034 10.7270/Q2PN95V2 19654408 Zarrinkar, PP; Gunawardane, RN; Cramer, MD; Gardner, MF; Brigham, D; Belli, B; Karaman, MW; Pratz, KW; Pallares, G; Chao, Q; Sprankle, KG; Patel, HK; Levis, M; Armstrong, RC; James, J; Bhagwat, SS Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50326054 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50326054&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 52945601 123105169 CHEMBL1240703 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50633678 Cn1c2nc(NC(CCO)CCO)ncc2cc(Oc2ccc(F)cc2F)c1=O InChI=1S/C19H20F2N4O4/c1-25-17-11(10-22-19(24-17)23-13(4-6-26)5-7-27)8-16(18(25)28)29-15-3-2-12(20)9-14(15)21/h2-3,8-10,13,26-27H,4-7H2,1H3,(H,22,23,24) JYYLVUFNAHSSFE-UHFFFAOYSA-N 50314070 6-(2,4-difluorophenoxy)-2-{[3-hydroxy-1-(2-hydroxyethyl)propyl]amino}-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one::CHEMBL1090089::pamapimod Ribosomal protein S6 kinase alpha-3 Homo sapiens 300 ChEMBL 10.1021/jm101423y 10.7270/Q20P109X 21375264 Goldstein, DM; Soth, M; Gabriel, T; Dewdney, N; Kuglstatter, A; Arzeno, H; Chen, J; Bingenheimer, W; Dalrymple, SA; Dunn, J; Farrell, R; Frauchiger, S; La Fargue, J; Ghate, M; Graves, B; Hill, RJ; Li, F; Litman, R; Loe, B; McIntosh, J; McWeeney, D; Papp, E; Park, J; Reese, HF; Roberts, RT; Rotstein, D; San Pablo, B; Sarma, K; Stahl, M; Sung, ML; Suttman, RT; Sjogren, EB; Tan, Y; Trejo, A; Welch, M; Weller, P; Wong, BR; Zecic, H Roche Palo Alto LLC http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50314070 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50314070&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search FLW 3FLW 16220188 104148431 CHEMBL1090089 ZINC30691792 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50633743 Cn1c2nc(NC3CCOCC3)ncc2cc(Oc2ccc(F)cc2F)c1=O InChI=1S/C19H18F2N4O3/c1-25-17-11(10-22-19(24-17)23-13-4-6-27-7-5-13)8-16(18(25)26)28-15-3-2-12(20)9-14(15)21/h2-3,8-10,13H,4-7H2,1H3,(H,22,23,24) KKKRKRMVJRHDMG-UHFFFAOYSA-N 50341342 6-(2,4-difluorophenoxy)-8-methyl-2-(tetrahydro-2H-pyran-4-ylamino)pyrido[2,3-d]pyrimidin-7(8H)-one::CHEMBL1230122 Ribosomal protein S6 kinase alpha-3 Homo sapiens 150 ChEMBL 10.1021/jm101423y 10.7270/Q20P109X 21375264 Goldstein, DM; Soth, M; Gabriel, T; Dewdney, N; Kuglstatter, A; Arzeno, H; Chen, J; Bingenheimer, W; Dalrymple, SA; Dunn, J; Farrell, R; Frauchiger, S; La Fargue, J; Ghate, M; Graves, B; Hill, RJ; Li, F; Litman, R; Loe, B; McIntosh, J; McWeeney, D; Papp, E; Park, J; Reese, HF; Roberts, RT; Rotstein, D; San Pablo, B; Sarma, K; Stahl, M; Sung, ML; Suttman, RT; Sjogren, EB; Tan, Y; Trejo, A; Welch, M; Weller, P; Wong, BR; Zecic, H Roche Palo Alto LLC http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50341342 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50341342&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 3FN 3FLN 11406590 131344278 CHEMBL1230122 ZINC58633224 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50639497 Cc1ccc(cc1)-c1c(C(=O)CF)n(CCCO)c2ncnc(N)c12 InChI=1S/C18H19FN4O2/c1-11-3-5-12(6-4-11)14-15-17(20)21-10-22-18(15)23(7-2-8-24)16(14)13(25)9-19/h3-6,10,24H,2,7-9H2,1H3,(H2,20,21,22) IKLGYJACVCXYIL-UHFFFAOYSA-N 50248765 1-(4-amino-7-(3-hydroxypropyl)-5-p-tolyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl)-2-fluoroethanone::CHEMBL515414 Ribosomal protein S6 kinase alpha-3 Homo sapiens 15 ChEMBL 10.1021/jm200139j 10.7270/Q26M374H 21488662 Lu, W; Liu, X; Cao, X; Xue, M; Liu, K; Zhao, Z; Shen, X; Jiang, H; Xu, Y; Huang, J; Li, H East China University of Science and Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50248765 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50248765&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 644243 104103317 CHEMBL515414 ZINC06718642 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50639498 Cc1c(N)ccc2nc([nH]c12)-c1ccc(N)cc1 InChI=1S/C14H14N4/c1-8-11(16)6-7-12-13(8)18-14(17-12)9-2-4-10(15)5-3-9/h2-7H,15-16H2,1H3,(H,17,18) BEXBJUKRZILANI-UHFFFAOYSA-N 50343651 2-(4-aminophenyl)-4-methyl-1H-benzo[d]imidazol-5-amine::CHEMBL529177::TCMDC-124242 Ribosomal protein S6 kinase alpha-3 Homo sapiens 320 ChEMBL 10.1021/jm200139j 10.7270/Q26M374H 21488662 Lu, W; Liu, X; Cao, X; Xue, M; Liu, K; Zhao, Z; Shen, X; Jiang, H; Xu, Y; Huang, J; Li, H East China University of Science and Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50343651 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50343651&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 1160249 131346587 CHEMBL529177 ZINC00911797 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50639499 Oc1ccc(NCn2nnc3ccccc23)cc1 InChI=1S/C13H12N4O/c18-11-7-5-10(6-8-11)14-9-17-13-4-2-1-3-12(13)15-16-17/h1-8,14,18H,9H2 FGZLHPMNJNFFNE-UHFFFAOYSA-N 50343652 4-((1H-benzo[d][1,2,3]triazol-1-yl)methylamino)phenol::CHEMBL1775067 Ribosomal protein S6 kinase alpha-3 Homo sapiens 480 ChEMBL 10.1021/jm200139j 10.7270/Q26M374H 21488662 Lu, W; Liu, X; Cao, X; Xue, M; Liu, K; Zhao, Z; Shen, X; Jiang, H; Xu, Y; Huang, J; Li, H East China University of Science and Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50343652 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50343652&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 899653 131346588 CHEMBL1775067 ZINC00477923 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50639500 O=C1N(CNc2ccc(cc2)N2CCOCC2)C(=O)c2ccccc12 InChI=1S/C19H19N3O3/c23-18-16-3-1-2-4-17(16)19(24)22(18)13-20-14-5-7-15(8-6-14)21-9-11-25-12-10-21/h1-8,20H,9-13H2 NMFDNVJXDZBLQR-UHFFFAOYSA-N 50343653 2-((4-morpholinophenylamino)methyl)isoindoline-1,3-dione::CHEMBL1775068 Ribosomal protein S6 kinase alpha-3 Homo sapiens 950 ChEMBL 10.1021/jm200139j 10.7270/Q26M374H 21488662 Lu, W; Liu, X; Cao, X; Xue, M; Liu, K; Zhao, Z; Shen, X; Jiang, H; Xu, Y; Huang, J; Li, H East China University of Science and Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50343653 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50343653&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 2731384 131346589 CHEMBL1775068 ZINC00098417 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50639501 Cc1cc(N)cc2[nH]c(nc12)-c1ccccc1 InChI=1S/C14H13N3/c1-9-7-11(15)8-12-13(9)17-14(16-12)10-5-3-2-4-6-10/h2-8H,15H2,1H3,(H,16,17) SYANUMFPPNVWHF-UHFFFAOYSA-N 50343654 4-methyl-2-phenyl-1H-benzo[d]imidazol-6-amine::CHEMBL1775069 Ribosomal protein S6 kinase alpha-3 Homo sapiens 1060 ChEMBL 10.1021/jm200139j 10.7270/Q26M374H 21488662 Lu, W; Liu, X; Cao, X; Xue, M; Liu, K; Zhao, Z; Shen, X; Jiang, H; Xu, Y; Huang, J; Li, H East China University of Science and Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50343654 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50343654&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 834921 131346590 CHEMBL1775069 ZINC00361081 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50639502 Cc1ccc2nc(oc2c1)-c1cc(N)cc(C)c1O InChI=1S/C15H14N2O2/c1-8-3-4-12-13(5-8)19-15(17-12)11-7-10(16)6-9(2)14(11)18/h3-7,18H,16H2,1-2H3 GXVKFQPECNZSJQ-UHFFFAOYSA-N 50343655 4-amino-2-methyl-6-(6-methylbenzo[d]oxazol-2-yl)phenol::CHEMBL1775070 Ribosomal protein S6 kinase alpha-3 Homo sapiens 1380 ChEMBL 10.1021/jm200139j 10.7270/Q26M374H 21488662 Lu, W; Liu, X; Cao, X; Xue, M; Liu, K; Zhao, Z; Shen, X; Jiang, H; Xu, Y; Huang, J; Li, H East China University of Science and Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50343655 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50343655&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 5741591 131346591 CHEMBL1775070 ZINC04412667 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50639503 Oc1ccc(cc1)N=Nc1c(O)[nH]c(=O)[nH]c1=O InChI=1S/C10H8N4O4/c15-6-3-1-5(2-4-6)13-14-7-8(16)11-10(18)12-9(7)17/h1-4,15H,(H3,11,12,16,17,18) TWGOJILVCXFFAT-UHFFFAOYSA-N 50343656 5-(2-(4-hydroxyphenyl)hydrazono)pyrimidine-2,4,6(1H,3H,5H)-trione::CHEMBL1775071 Ribosomal protein S6 kinase alpha-3 Homo sapiens 1580 ChEMBL 10.1021/jm200139j 10.7270/Q26M374H 21488662 Lu, W; Liu, X; Cao, X; Xue, M; Liu, K; Zhao, Z; Shen, X; Jiang, H; Xu, Y; Huang, J; Li, H East China University of Science and Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50343656 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50343656&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 6025709 131346592 CHEMBL1775071 ZINC06863164 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50639504 Clc1ccc2N=C(NSc2c1)c1ccccc1 InChI=1S/C13H9ClN2S/c14-10-6-7-11-12(8-10)17-16-13(15-11)9-4-2-1-3-5-9/h1-8H,(H,15,16) GAXKSUFPFQNLPM-UHFFFAOYSA-N 50343657 7-chloro-3-phenyl-2H-benzo[e][1,2,4]thiadiazine::CHEMBL1775072 Ribosomal protein S6 kinase alpha-3 Homo sapiens 2880 ChEMBL 10.1021/jm200139j 10.7270/Q26M374H 21488662 Lu, W; Liu, X; Cao, X; Xue, M; Liu, K; Zhao, Z; Shen, X; Jiang, H; Xu, Y; Huang, J; Li, H East China University of Science and Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50343657 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50343657&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 902492 131346593 CHEMBL1775072 ZINC00482059 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50639505 Oc1ccccc1NC(=O)c1cnns1 InChI=1S/C9H7N3O2S/c13-7-4-2-1-3-6(7)11-9(14)8-5-10-12-15-8/h1-5,13H,(H,11,14) QCZDUQMMGOOKGP-UHFFFAOYSA-N 50343658 CHEMBL1775073::N-(2-hydroxyphenyl)-1,2,3-thiadiazole-5-carboxamide Ribosomal protein S6 kinase alpha-3 Homo sapiens 3030 ChEMBL 10.1021/jm200139j 10.7270/Q26M374H 21488662 Lu, W; Liu, X; Cao, X; Xue, M; Liu, K; Zhao, Z; Shen, X; Jiang, H; Xu, Y; Huang, J; Li, H East China University of Science and Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50343658 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50343658&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 47262210 131346594 CHEMBL1775073 ZINC47816706 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50639506 OC(=O)c1ccc(cc1)N=Nc1ccc(O)c2ncccc12 InChI=1S/C16H11N3O3/c20-14-8-7-13(12-2-1-9-17-15(12)14)19-18-11-5-3-10(4-6-11)16(21)22/h1-9,20H,(H,21,22) WHYSDEAUKYVHBQ-UHFFFAOYSA-N 50343659 (E)-4-((8-hydroxyquinolin-5-yl)diazenyl)benzoic acid::CHEMBL1775074 Ribosomal protein S6 kinase alpha-3 Homo sapiens 3470 ChEMBL 10.1021/jm200139j 10.7270/Q26M374H 21488662 Lu, W; Liu, X; Cao, X; Xue, M; Liu, K; Zhao, Z; Shen, X; Jiang, H; Xu, Y; Huang, J; Li, H East China University of Science and Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50343659 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50343659&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 5887843 131346595 CHEMBL1775074 ZINC04993968 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50639507 Nc1n[nH]c(N)c1\N=N\c1ccc(cc1)S(N)(=O)=O InChI=1S/C9H11N7O2S/c10-8-7(9(11)16-15-8)14-13-5-1-3-6(4-2-5)19(12,17)18/h1-4H,(H2,12,17,18)(H5,10,11,15,16)/b14-13+ XLIZDMWIBNVIPS-BUHFOSPRSA-N 50343660 4-((3,5-diamino-1H-pyrazol-4-yl)diazenyl)benzenesulfonamide::CHEMBL1775075 Ribosomal protein S6 kinase alpha-3 Homo sapiens 5500 ChEMBL 10.1021/jm200139j 10.7270/Q26M374H 21488662 Lu, W; Liu, X; Cao, X; Xue, M; Liu, K; Zhao, Z; Shen, X; Jiang, H; Xu, Y; Huang, J; Li, H East China University of Science and Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50343660 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50343660&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 5869730 131346596 CHEMBL1775075 ZINC04657707 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50639508 Oc1nc(N=Nc2ccccc2)[nH]c1C#N InChI=1S/C10H7N5O/c11-6-8-9(16)13-10(12-8)15-14-7-4-2-1-3-5-7/h1-5,16H,(H,12,13) QJEMLMZIGQTOAG-UHFFFAOYSA-N 50343661 5-hydroxy-2-(phenyldiazenyl)-1H-imidazole-4-carbonitrile::CHEMBL1775076 Ribosomal protein S6 kinase alpha-3 Homo sapiens 7040 ChEMBL 10.1021/jm200139j 10.7270/Q26M374H 21488662 Lu, W; Liu, X; Cao, X; Xue, M; Liu, K; Zhao, Z; Shen, X; Jiang, H; Xu, Y; Huang, J; Li, H East China University of Science and Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50343661 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50343661&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 6180818 131346597 CHEMBL1775076 ZINC05614811 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50639509 Nc1nc2[nH]c(=O)[nH]c(=O)c2s1 InChI=1S/C5H4N4O2S/c6-4-7-2-1(12-4)3(10)9-5(11)8-2/h(H4,6,7,8,9,10,11) BCEGWKBJRRLBBC-UHFFFAOYSA-N 50343662 2-aminothiazolo[4,5-d]pyrimidine-5,7-diol::CHEMBL1775077 Ribosomal protein S6 kinase alpha-3 Homo sapiens 9990 ChEMBL 10.1021/jm200139j 10.7270/Q26M374H 21488662 Lu, W; Liu, X; Cao, X; Xue, M; Liu, K; Zhao, Z; Shen, X; Jiang, H; Xu, Y; Huang, J; Li, H East China University of Science and Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50343662 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50343662&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 1225079 131346598 CHEMBL1775077 ZINC01515385 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50639510 FC(F)(F)c1ccc(NNC(=O)c2ccccc2Cl)nc1 InChI=1S/C13H9ClF3N3O/c14-10-4-2-1-3-9(10)12(21)20-19-11-6-5-8(7-18-11)13(15,16)17/h1-7H,(H,18,19)(H,20,21) JIRNTLWLMRPLAY-UHFFFAOYSA-N 50343663 2-chloro-N'-(5-(trifluoromethyl)pyridin-2-yl)benzohydrazide::CHEMBL1775078 Ribosomal protein S6 kinase alpha-3 Homo sapiens 13180 ChEMBL 10.1021/jm200139j 10.7270/Q26M374H 21488662 Lu, W; Liu, X; Cao, X; Xue, M; Liu, K; Zhao, Z; Shen, X; Jiang, H; Xu, Y; Huang, J; Li, H East China University of Science and Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50343663 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50343663&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 587331 131346599 CHEMBL1775078 ZINC00077916 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50639511 Oc1ccc(cc1)-c1cnc2c(n1)[nH]c(=O)[nH]c2=O InChI=1S/C12H8N4O3/c17-7-3-1-6(2-4-7)8-5-13-9-10(14-8)15-12(19)16-11(9)18/h1-5,17H,(H2,14,15,16,18,19) HNJURXDJCHCAST-UHFFFAOYSA-N 50343664 7-(4-hydroxyphenyl)pteridine-2,4-diol::CHEMBL1775079 Ribosomal protein S6 kinase alpha-3 Homo sapiens 14450 ChEMBL 10.1021/jm200139j 10.7270/Q26M374H 21488662 Lu, W; Liu, X; Cao, X; Xue, M; Liu, K; Zhao, Z; Shen, X; Jiang, H; Xu, Y; Huang, J; Li, H East China University of Science and Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50343664 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50343664&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 5409693 131346600 CHEMBL1775079 ZINC06493905 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50639512 Cc1c(C)c(ccc1O)N=Nc1ccc(cc1)S(O)(=O)=O InChI=1S/C14H14N2O4S/c1-9-10(2)14(17)8-7-13(9)16-15-11-3-5-12(6-4-11)21(18,19)20/h3-8,17H,1-2H3,(H,18,19,20) QRUSUZHYKIOUKW-UHFFFAOYSA-N 50343665 4-((4-hydroxy-2,3-dimethylphenyl)diazenyl)benzenesulfonic acid::CHEMBL1775080 Ribosomal protein S6 kinase alpha-3 Homo sapiens 15140 ChEMBL 10.1021/jm200139j 10.7270/Q26M374H 21488662 Lu, W; Liu, X; Cao, X; Xue, M; Liu, K; Zhao, Z; Shen, X; Jiang, H; Xu, Y; Huang, J; Li, H East China University of Science and Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50343665 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50343665&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 6511326 131346601 CHEMBL1775080 ZINC04127673 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50639513 COc1cc(\C=N\n2cnnc2)cc(I)c1O InChI=1S/C10H9IN4O2/c1-17-9-3-7(2-8(11)10(9)16)4-14-15-5-12-13-6-15/h2-6,16H,1H3/b14-4+ LUYJJBGVWZBKSL-LNKIKWGQSA-N 50343666 4-((4H-1,2,4-triazol-4-ylimino)methyl)-2-iodo-6-methoxyphenol::CHEMBL1775081 Ribosomal protein S6 kinase alpha-3 Homo sapiens 16180 ChEMBL 10.1021/jm200139j 10.7270/Q26M374H 21488662 Lu, W; Liu, X; Cao, X; Xue, M; Liu, K; Zhao, Z; Shen, X; Jiang, H; Xu, Y; Huang, J; Li, H East China University of Science and Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50343666 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50343666&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 5754941 131346602 CHEMBL1775081 ZINC00297344 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50639514 Cn1cc(C2=C(C(=O)NC2=O)c2cn(CCCSC(N)=N)c3ccccc23)c2ccccc12 InChI=1S/C25H23N5O2S/c1-29-13-17(15-7-2-4-9-19(15)29)21-22(24(32)28-23(21)31)18-14-30(11-6-12-33-25(26)27)20-10-5-3-8-16(18)20/h2-5,7-10,13-14H,6,11-12H2,1H3,(H3,26,27)(H,28,31,32) DSXXEELGXBCYNQ-UHFFFAOYSA-N 3175 3-[1-[3-(Amidinothio)propyl]-3-indolyl]-4-(1-methyl-3-indolyl)-1H-pyrrole-2,5-dione Methanesulfonate::BIM-9::Bisindolylmaleimide 11b::Bisindolylmaleimide IX::CHEMBL6291::ROCHE screening, 57::Ro 31-8220::Ro31-8220::[(3-{3-[4-(1-methyl-1H-indol-3-yl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl]-1H-indol-1-yl}propyl)sulfanyl]methanimidamide Ribosomal protein S6 kinase alpha-3 Homo sapiens 10 ChEMBL 10.1021/jm200139j 10.7270/Q26M374H 21488662 Lu, W; Liu, X; Cao, X; Xue, M; Liu, K; Zhao, Z; Shen, X; Jiang, H; Xu, Y; Huang, J; Li, H East China University of Science and Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=3175 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=3175&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search DRN 2V7O,4OTH 5083 8032918 38912 CHEMBL6291 5259 ZINC03797930 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50667066 CS(=O)(=O)N1CCN(Cc2cc3nc(nc(N4CCOCC4)c3s2)-c2cccc3[nH]ncc23)CC1 InChI=1S/C23H27N7O3S2/c1-35(31,32)30-7-5-28(6-8-30)15-16-13-20-21(34-16)23(29-9-11-33-12-10-29)26-22(25-20)17-3-2-4-19-18(17)14-24-27-19/h2-4,13-14H,5-12,15H2,1H3,(H,24,27) LHNIIDJUOCFXAP-UHFFFAOYSA-N 25028 4-[2-(1H-indazol-4-yl)-6-[(4-methanesulfonylpiperazin-1-yl)methyl]thieno[3,2-d]pyrimidin-4-yl]morpholine::GDC-0941::GDC0941::US10112932, pictilisib::US10851091, Compound pictilisib Ribosomal protein S6 kinase alpha-3 Homo sapiens 3000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25028 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25028&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search GD9 3DBS,2Y3A,2WXP 17755052 56374172 65326 ZINC16052714 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50668379 COc1cc(Nc2ncc(F)c(Nc3ccc4OC(C)(C)C(=O)Nc4n3)n2)cc(OC)c1OC InChI=1S/C22H23FN6O5/c1-22(2)20(30)28-19-13(34-22)6-7-16(27-19)26-18-12(23)10-24-21(29-18)25-11-8-14(31-3)17(33-5)15(9-11)32-4/h6-10H,1-5H3,(H3,24,25,26,27,28,29,30) NHHQJBCNYHBUSI-UHFFFAOYSA-N 60665 BDBM50249542::US9145414, R406::US9212178, R406 Ribosomal protein S6 kinase alpha-3 Homo sapiens 8000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=60665 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=60665&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 585 3PIY,3FQS 11213558 316921779 DB07159 ZINC13555629 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50668649 COc1cc2c(Nc3ccc(Br)cc3F)ncnc2cc1OCC1CCN(C)CC1 InChI=1S/C22H24BrFN4O2/c1-28-7-5-14(6-8-28)12-30-21-11-19-16(10-20(21)29-2)22(26-13-25-19)27-18-4-3-15(23)9-17(18)24/h3-4,9-11,13-14H,5-8,12H2,1-2H3,(H,25,26,27) UHTHHESEBZOYNR-UHFFFAOYSA-N 21 CHEMBL24828::N-(4-bromo-2-fluorophenyl)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazolin-4-amine::VANDETANIB::ZD-6474::ZD6474::cid_3081361 Ribosomal protein S6 kinase alpha-3 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=21 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=21&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search ZD6 2IVU 3081361 8030012 49960 CHEMBL24828 DB08764 ZINC03834198 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50667389 CN1CCN(Cc2ccc(cc2)C(=O)Nc2ccc(C)c(Nc3nc(cs3)-c3cccnc3)c2)CC1 InChI=1S/C28H30N6OS/c1-20-5-10-24(16-25(20)31-28-32-26(19-36-28)23-4-3-11-29-17-23)30-27(35)22-8-6-21(7-9-22)18-34-14-12-33(2)13-15-34/h3-11,16-17,19H,12-15,18H2,1-2H3,(H,30,35)(H,31,32) WJEOLQLKVOPQFV-UHFFFAOYSA-N 50355495 CHEMBL1908391 Ribosomal protein S6 kinase alpha-3 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50355495 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50355495&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search G65 7TVX,5MQL,7JU7 10074640 136959519 63450 CHEMBL1908391 ZINC34177219 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50667526 O=C(N1CCNCC1)c1ccc(\C=C\c2n[nH]c3ccccc23)cc1 InChI=1S/C20H20N4O/c25-20(24-13-11-21-12-14-24)16-8-5-15(6-9-16)7-10-19-17-3-1-2-4-18(17)22-23-19/h1-10,21H,11-14H2,(H,22,23)/b10-7+ YYLKKYCXAOBSRM-JXMROGBWSA-N 50355496 CHEMBL1908397 Ribosomal protein S6 kinase alpha-3 Homo sapiens 280 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50355496 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50355496&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 11427553 136959520 CHEMBL1908397 ZINC43201999 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50667707 Cc1n[nH]c2ccc(cc12)-c1cncc(OC[C@@H](N)Cc2ccccc2)c1 InChI=1S/C22H22N4O/c1-15-21-11-17(7-8-22(21)26-25-15)18-10-20(13-24-12-18)27-14-19(23)9-16-5-3-2-4-6-16/h2-8,10-13,19H,9,14,23H2,1H3,(H,25,26)/t19-/m0/s1 BPNUQXPIQBZCMR-IBGZPJMESA-N 15138 5-indazolyl pyridine 11g::5-{5-[(2S)-2-amino-3-phenylpropoxy]pyridin-3-yl}-3-methyl-1H-indazole::A-674563::Biochemistry 469551 Compound 11::indazole-pyridine, 7 Ribosomal protein S6 kinase alpha-3 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=15138 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=15138&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search SS3 2UZT 11314340 46515449 DB08568 5655 ZINC16052569 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50649986 CSc1cn2c(cnc2c(Nc2cc(C)ns2)n1)-c1cn[nH]c1 InChI=1S/C14H13N7S2/c1-8-3-11(23-20-8)18-13-14-15-6-10(9-4-16-17-5-9)21(14)7-12(19-13)22-2/h3-7H,1-2H3,(H,16,17)(H,18,19) FTFDOZLQPLTYBX-UHFFFAOYSA-N 50348621 CHEMBL1270795 Ribosomal protein S6 kinase alpha-3 Homo sapiens 1306 ChEMBL 10.1016/j.bmcl.2010.07.008 10.7270/Q2Q81DGH 20674350 Belanger, DB; Curran, PJ; Hruza, A; Voigt, J; Meng, Z; Mandal, AK; Siddiqui, MA; Basso, AD; Gray, K Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50348621 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50348621&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 25094210 136355307 CHEMBL1270795 ZINC43195259 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50682495 COc1cc(Oc2ccnc3cc(OC)c(OC)cc23)ccc1NC(=O)NC(C)c1nccs1 InChI=1S/C24H24N4O5S/c1-14(23-26-9-10-34-23)27-24(29)28-17-6-5-15(11-20(17)30-2)33-19-7-8-25-18-13-22(32-4)21(31-3)12-16(18)19/h5-14H,1-4H3,(H2,27,28,29) SHPFDGWALWEPGS-UHFFFAOYSA-N 50355494 CHEMBL1908396 Ribosomal protein S6 kinase alpha-3 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50355494 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50355494&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 9869779 136959518 CHEMBL1908396 ZINC13975055 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50691162 CCN1CCN(Cc2ccc(NC(=O)Nc3ccc(Oc4cc(NC)ncn4)cc3)cc2C(F)(F)F)CC1 InChI=1S/C26H30F3N7O2/c1-3-35-10-12-36(13-11-35)16-18-4-5-20(14-22(18)26(27,28)29)34-25(37)33-19-6-8-21(9-7-19)38-24-15-23(30-2)31-17-32-24/h4-9,14-15,17H,3,10-13,16H2,1-2H3,(H,30,31,32)(H2,33,34,37) ODPGGGTTYSGTGO-UHFFFAOYSA-N 31085 1-[4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-3-[4-[[6-(methylamino)-4-pyrimidinyl]oxy]phenyl]urea::1-[4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-3-[4-[6-(methylamino)pyrimidin-4-yl]oxyphenyl]urea::1-[4-[(4-ethylpiperazino)methyl]-3-(trifluoromethyl)phenyl]-3-[4-[6-(methylamino)pyrimidin-4-yl]oxyphenyl]urea::AST-487::cid_11409972 Ribosomal protein S6 kinase alpha-3 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31085 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31085&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 11409972 252615335 5661 ZINC23247639 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50675401 CC(C)n1nc(-c2cc3cc(O)ccc3[nH]2)c2c(N)ncnc12 InChI=1S/C16H16N6O/c1-8(2)22-16-13(15(17)18-7-19-16)14(21-22)12-6-9-5-10(23)3-4-11(9)20-12/h3-8,20,23H,1-2H3,(H2,17,18,19) MFAQYJIYDMLAIM-UHFFFAOYSA-N 36409 2-(4-amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-1H-indol-5-ol, PP242::CID24905147::US10172858, Table 2.1::US9828378, # 1 Ribosomal protein S6 kinase alpha-3 Homo sapiens 200 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=36409 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=36409&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search P2X 4JT5 24905147 117643995 ZINC36056301 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50689731 CN1CCN(CC1)c1ccc2nc([nH]c2c1)-c1c(N)c2c(F)cccc2[nH]c1=O InChI=1S/C21H21FN6O/c1-27-7-9-28(10-8-27)12-5-6-14-16(11-12)25-20(24-14)18-19(23)17-13(22)3-2-4-15(17)26-21(18)29/h2-6,11H,7-10H2,1H3,(H,24,25)(H3,23,26,29) PIQCTGMSNWUMAF-UHFFFAOYSA-N 25118 (3Z)-4-amino-5-fluoro-3-[5-(4-methylpiperazino)-1,3-dihydrobenzimidazol-2-ylidene]carbostyril::4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-1,3-benzodiazol-2-yl]-1,2-dihydroquinolin-2-one::CHEMBL522892::CHIR-258 Ribosomal protein S6 kinase alpha-3 Homo sapiens 5600 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25118 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25118&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 9886808 56374260 CHEMBL522892 5962 ZINC03816310 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50689766 Cc1cn(cn1)-c1cc(NC(=O)c2ccc(C)c(Nc3nccc(n3)-c3cccnc3)c2)cc(c1)C(F)(F)F InChI=1S/C28H22F3N7O/c1-17-5-6-19(10-25(17)37-27-33-9-7-24(36-27)20-4-3-8-32-14-20)26(39)35-22-11-21(28(29,30)31)12-23(13-22)38-15-18(2)34-16-38/h3-16H,1-2H3,(H,35,39)(H,33,36,37) HHZIURLSWUIHRB-UHFFFAOYSA-N 50237710 4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]benzamide::AMN 107::AMN107::CHEMBL255863::NILOTINIB::US11649218, Example Nilotinib Ribosomal protein S6 kinase alpha-3 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50237710 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50237710&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search NIL 5MO4,3CS9,3GP0 644241 104056419 52172 CHEMBL255863 DB04868 5697 ZINC06716957 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50669639 Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(OCCN2CCOCC2)c2ccccc12)C(C)(C)C InChI=1S/C31H37N5O3/c1-22-9-11-23(12-10-22)36-29(21-28(34-36)31(2,3)4)33-30(37)32-26-13-14-27(25-8-6-5-7-24(25)26)39-20-17-35-15-18-38-19-16-35/h5-14,21H,15-20H2,1-4H3,(H2,32,33,37) MVCOAUNKQVWQHZ-UHFFFAOYSA-N 13533 1-[2-(4-methylphenyl)-5-tert-butyl-pyrazol-3-yl]-3-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea::1-[5-tert-butyl-2-(4-methylphenyl)-3-pyrazolyl]-3-[4-[2-(4-morpholinyl)ethoxy]-1-naphthalenyl]urea::1-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea::1-[5-tert-butyl-2-(p-tolyl)pyrazol-3-yl]-3-[4-(2-morpholinoethoxy)-1-naphthyl]urea::3-[2-(4-methylphenyl)-5-tert-butyl-pyrazol-3-yl]-1-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea::3-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]-1-{4-[2-(morpholin-4-yl)ethoxy]naphthalen-1-yl}urea::BIRB 796::BIRB-796::BIRB-796, 3::CHEMBL103667::D3RKN_73::Doramapimod::US11407771, Compound 43::US8933228, BIRB 796::US9187470, 43 (BIRB-796)::US9242960, BIRB 796::US9260410, BIRB796::cid_156422::diaryl urea compound 10 Ribosomal protein S6 kinase alpha-3 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13533 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13533&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search B96 4JVG,1KV2,6GTT,5N66,4TWN,3NPC,3FZS 156422 46513934 CHEMBL103667 DB03044 5668 ZINC24044436 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50675492 CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)cc2)ccn1 InChI=1S/C21H16ClF3N4O3/c1-26-19(30)18-11-15(8-9-27-18)32-14-5-2-12(3-6-14)28-20(31)29-13-4-7-17(22)16(10-13)21(23,24)25/h2-11H,1H3,(H,26,30)(H2,28,29,31) MLDQJTXFUGDVEO-UHFFFAOYSA-N 16673 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)phenoxy]-N-methylpyridine-2-carboxamide::4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methyl-picolinamide;tosylic acid::BAY 43-9006::BAY 439006::BAY439006::CHEMBL1336::Hit compound, 8::Nexavar::Sorafenib::Sorafenib, 4::US10183928, Sorafenib::US10202365, Compound Sorafenib::US10227329, Compound Sorafenib::US10584114, Compound Sorafenib::US10774070, Compound Sorafenib::US10980809, Example Sorafenib::US11279688, Compound Sorafenib::US11505527, Compound Sorafenib::US9029401, Sorafenib::US9469639, Sorafenib::US9902709, Comparative example 1::Xarelto::cid_216239 Ribosomal protein S6 kinase alpha-3 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=16673 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=16673&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search BAX 3GCS,4ASD,3WZE,5HI2,3HEG,1UWH,1UWJ,3RGF 216239 46516901 50924 CHEMBL1336 DB00398 5711 ZINC01493878 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50682670 CCOc1cc2ncc(C#N)c(Nc3ccc(OCc4ccccn4)c(Cl)c3)c2cc1NC(=O)\C=C\CN(C)C InChI=1S/C30H29ClN6O3/c1-4-39-28-16-25-23(15-26(28)36-29(38)9-7-13-37(2)3)30(20(17-32)18-34-25)35-21-10-11-27(24(31)14-21)40-19-22-8-5-6-12-33-22/h5-12,14-16,18H,4,13,19H2,1-3H3,(H,34,35)(H,36,38)/b9-7+ JWNPDZNEKVCWMY-VQHVLOKHSA-N 50161957 4-Dimethylamino-but-2-enoic acid {4-[3-chloro-4-(pyridin-2-ylmethoxy)-phenylamino]-3-cyano-7-ethoxy-quinolin-6-yl}-amide::CHEMBL180022::HKI-272::N-(4-(3-chloro-4-(pyridin-2-ylmethoxy)phenylamino)-3-cyano-7-ethoxyquinolin-6-yl)-4-(dimethylamino)but-2-enamide::N-(4-(3-chloro-4-(pyridin-2-ylmethoxy)phenylamino)-3-cyano-7-ethoxyquinolin-6-yl)-4-(dimethylamino)butanamide::NERATINIB::US10822334, Compound Neratinib Ribosomal protein S6 kinase alpha-3 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50161957 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50161957&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 9915743 104048227 CHEMBL180022 5686 ZINC03916214 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50686808 CN1CC[C@@H]([C@H](O)C1)c1c(O)cc(O)c2c1oc(cc2=O)-c1ccccc1Cl InChI=1S/C21H20ClNO5/c1-23-7-6-12(17(27)10-23)19-14(24)8-15(25)20-16(26)9-18(28-21(19)20)11-4-2-3-5-13(11)22/h2-5,8-9,12,17,24-25,27H,6-7,10H2,1H3/t12-,17+/m0/s1 BIIVYFLTOXDAOV-YVEFUNNKSA-N 5655 2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methylpiperidin-4-yl]-4H-chromen-4-one::CHEMBL428690::Flavopiridol::US10294218, Example Flavopiridol::US9617225, Flavopiridol Ribosomal protein S6 kinase alpha-3 Homo sapiens 1000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=5655 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=5655&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search CPB 1C8K,1E1Y,3BLR,3EBP,4O71 5287969 8035270 CHEMBL428690 DB03496 5680 ZINC21288966 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50672620 Fc1ccc(C(=O)NOCC2CC2)c(Nc2ccc(I)cc2Cl)c1F InChI=1S/C17H14ClF2IN2O2/c18-12-7-10(21)3-6-14(12)22-16-11(4-5-13(19)15(16)20)17(24)23-25-8-9-1-2-9/h3-7,9,22H,1-2,8H2,(H,23,24) GFMMXOIFOQCCGU-UHFFFAOYSA-N 50132260 2-(2-Chloro-4-iodo-phenylamino)-N-cyclopropylmethoxy-3,4-difluoro-benzamide::2-(2-chloro-4-iodophenylamino)-N-(cyclopropylmethoxy)-3,4-difluorobenzamide::CHEMBL105442::CI-1040::PD-18435::PD-184352::US8575391, 341 Ribosomal protein S6 kinase alpha-3 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50132260 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50132260&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 6918454 104023279 CHEMBL105442 5676 ZINC01489691 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50674141 COc1ccc(COc2ccc(Cc3cnc(N)nc3N)cc2OC)cc1 InChI=1S/C20H22N4O3/c1-25-16-6-3-13(4-7-16)12-27-17-8-5-14(10-18(17)26-2)9-15-11-23-20(22)24-19(15)21/h3-8,10-11H,9,12H2,1-2H3,(H4,21,22,23,24) MYQAUKPBNJWPIE-UHFFFAOYSA-N 32362 5-[[3-methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]methyl]pyrimidine-2,4-diamine::GW-2580::[2-amino-5-(3-methoxy-4-p-anisyloxy-benzyl)pyrimidin-4-yl]amine::cid_11617559 Ribosomal protein S6 kinase alpha-3 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=32362 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=32362&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search MUJ 4AT5 11617559 252615797 5685 ZINC13985942 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50678418 CC(C)(C)c1cnc(CSc2cnc(NC(=O)C3CCNCC3)s2)o1 InChI=1S/C17H24N4O2S2/c1-17(2,3)12-8-19-13(23-12)10-24-14-9-20-16(25-14)21-15(22)11-4-6-18-7-5-11/h8-9,11,18H,4-7,10H2,1-3H3,(H,20,21,22) OUSFTKFNBAZUKL-UHFFFAOYSA-N 5931 BMS-387072::CHEMBL296468::N-(5-{[(5-tert-butyl-1,3-oxazol-2-yl)methyl]sulfanyl}-1,3-thiazol-2-yl)piperidine-4-carboxamide::N-[5-[[[5-(1,1-Dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4-piperidinecarboxamide::cid_3025986 Ribosomal protein S6 kinase alpha-3 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=5931 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=5931&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 56H 5D1J 3025986 8035540 CHEMBL296468 5670 ZINC03816409 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50689943 C[C@@H](O)COc1cn2ncnc(Oc3ccc4[nH]c(C)cc4c3F)c2c1C InChI=1S/C19H19FN4O3/c1-10-6-13-14(23-10)4-5-15(17(13)20)27-19-18-12(3)16(26-8-11(2)25)7-24(18)22-9-21-19/h4-7,9,11,23,25H,8H2,1-3H3/t11-/m1/s1 WCWUXEGQKLTGDX-LLVKDONJSA-N 50184807 (R)-1-(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-methylpyrrolo[1,2-f][1,2,4]triazin-6-yloxy)propan-2-ol::(R)-1-(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yloxy)propan-2-ol::BMS-540215::CHEMBL377300 Ribosomal protein S6 kinase alpha-3 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50184807 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50184807&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 11234052 104069124 CHEMBL377300 5671 ZINC13684256 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50691338 Cc1cnc2c(NCCN)nc3ccc(C)cc3n12 InChI=1S/C14H17N5/c1-9-3-4-11-12(7-9)19-10(2)8-17-14(19)13(18-11)16-6-5-15/h3-4,7-8H,5-6,15H2,1-2H3,(H,16,18) PSPFQEBFYXJZEV-UHFFFAOYSA-N 25919 BMS-345541::BMS345541::CHEMBL471496::N-(2-aminoethyl)-3,12-dimethyl-2,5,8-triazatricyclo[7.4.0.0^{2,6}]trideca-1(13),3,5,7,9,11-hexaen-7-amine Ribosomal protein S6 kinase alpha-3 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25919 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25919&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 9813758 56413207 CHEMBL471496 5669 ZINC13285379 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50669796 CNC(=O)c1c(F)cccc1Nc1nc(Nc2cc3N(CCc3cc2OC)C(=O)CN(C)C)nc2[nH]ccc12 InChI=1S/C27H29FN8O3/c1-29-26(38)23-17(28)6-5-7-18(23)31-25-16-8-10-30-24(16)33-27(34-25)32-19-13-20-15(12-21(19)39-4)9-11-36(20)22(37)14-35(2)3/h5-8,10,12-13H,9,11,14H2,1-4H3,(H,29,38)(H3,30,31,32,33,34) HZTYDQRUAWIZRE-UHFFFAOYSA-N 27817 2-{[2-({1-[2-(dimethylamino)acetyl]-5-methoxy-2,3-dihydro-1H-indol-6-yl}amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]amino}-6-fluoro-N-methylbenzamide::pyrrolo[2,3-d]pyrimidine deriv., 40 Ribosomal protein S6 kinase alpha-3 Homo sapiens 170 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=27817 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=27817&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 25182616 57560329 5683 ZINC43202844 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50671143 CN1CCN(Cc2ccc(cc2)C(=O)Nc2ccc(C)c(Nc3nccc(n3)-c3cccnc3)c2)CC1 InChI=1S/C29H31N7O/c1-21-5-10-25(18-27(21)34-29-31-13-11-26(33-29)24-4-3-12-30-19-24)32-28(37)23-8-6-22(7-9-23)20-36-16-14-35(2)15-17-36/h3-13,18-19H,14-17,20H2,1-2H3,(H,32,37)(H,31,33,34) KTUFNOKKBVMGRW-UHFFFAOYSA-N 13530 4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]benzamide::CHEMBL941::Gleevec::Imatinib::Imatinib, 21::N-(4-methyl-3-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}phenyl)-4-[(4-methylpiperazin-1-yl)methyl]benzamide::STI-571::STI571::US10906896, Cpd imatinib::US11649218, Example Imatinib::US9255107, Imatinib::cid_5291::imatinib-CD3::med.21724, Compound 6 Ribosomal protein S6 kinase alpha-3 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13530 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13530&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search STI 6HD6,6HD4,2HYY,4BKJ,2PL0,3GVU,6NPU,6NPV,6NPE,4CSV,3MS9,3MSS,4R7I,7N9G,2OIQ,1IEP,1XBB,3HEC,1T46,3FW1,3PYY,6VXH,6JOL,3K5V,5MQT,3OEZ,6KTN,1OPJ 5291 46513933 45783 CHEMBL941 DB00619 5687 ZINC19632618 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50672783 Cc1ccc(F)c(NC(=O)Nc2ccc(cc2)-c2cccc3[nH]nc(N)c23)c1 InChI=1S/C21H18FN5O/c1-12-5-10-16(22)18(11-12)25-21(28)24-14-8-6-13(7-9-14)15-3-2-4-17-19(15)20(23)27-26-17/h2-11H,1H3,(H3,23,26,27)(H2,24,25,28) MPVGZUGXCQEXTM-UHFFFAOYSA-N 21079 1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-(2-fluoro-5-methyl-phenyl)urea::1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-(2-fluoro-5-methylphenyl)urea::1-[4-(3-azanyl-1H-indazol-4-yl)phenyl]-3-(2-fluoranyl-5-methyl-phenyl)urea::3-[4-(3-amino-1H-indazol-4-yl)phenyl]-1-(2-fluoro-5-methylphenyl)urea::ABT-869::Aminoindazole, 3::CHEMBL223360::cid_11485656 Ribosomal protein S6 kinase alpha-3 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=21079 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=21079&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 11485656 49689152 CHEMBL223360 5657 ZINC06718813 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50675645 Cc1[nH]c(\C=C2/C(=O)Nc3ccc(cc23)S(=O)(=O)Cc2c(Cl)cccc2Cl)c(C)c1C(=O)N1CCC[C@@H]1CN1CCCC1 InChI=1S/C32H34Cl2N4O4S/c1-19-29(35-20(2)30(19)32(40)38-14-6-7-21(38)17-37-12-3-4-13-37)16-24-23-15-22(10-11-28(23)36-31(24)39)43(41,42)18-25-26(33)8-5-9-27(25)34/h5,8-11,15-16,21,35H,3-4,6-7,12-14,17-18H2,1-2H3,(H,36,39)/b24-16-/t21-/m1/s1 OYONTEXKYJZFHA-SSHUPFPWSA-N 50242737 (R,Z)-5-(2,6-dichlorobenzylsulfonyl)-3-((3,5-dimethyl-4-(2-(pyrrolidin-1-ylmethyl)pyrrolidine-1-carbonyl)-1H-pyrrol-2-yl)methylene)indolin-2-one::CHEMBL450786::PHA-665752::TCMDC-125885 Ribosomal protein S6 kinase alpha-3 Homo sapiens 9900 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50242737 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50242737&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 10461815 104099202 CHEMBL450786 5700 ZINC03938668 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50677101 COc1c(Cl)cc2c3ccncc3[nH]c2c1NC(=O)c1cccnc1C InChI=1S/C19H15ClN4O2/c1-10-11(4-3-6-22-10)19(25)24-17-16-13(8-14(20)18(17)26-2)12-5-7-21-9-15(12)23-16/h3-9,23H,1-2H3,(H,24,25) ZNOLRTPMNMPLHY-UHFFFAOYSA-N 50309910 CHEMBL608154::ML-120B::N-(6-chloro-7-methoxy-9H-pyrido[3,4-b]indol-8-yl)-2-methylnicotinamide Ribosomal protein S6 kinase alpha-3 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50309910 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50309910&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 9929127 104164271 CHEMBL608154 5694 ZINC06717113 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50688523 COc1cc2c(Oc3ccc(NC(=O)C4(CC4)C(=O)NC4=CCC(F)C=C4)cc3F)ccnc2cc1OCCCN1CCOCC1 InChI=1S/C34H36F2N4O6/c1-43-30-20-25-27(21-31(30)45-16-2-13-40-14-17-44-18-15-40)37-12-9-28(25)46-29-8-7-24(19-26(29)36)39-33(42)34(10-11-34)32(41)38-23-5-3-22(35)4-6-23/h3,5-9,12,19-22H,2,4,10-11,13-18H2,1H3,(H,38,41)(H,39,42) SEJGTFPOEJWEGG-UHFFFAOYSA-N 50355504 CHEMBL1908393 Ribosomal protein S6 kinase alpha-3 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50355504 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50355504&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 57399640 136959528 CHEMBL1908393 ZINC73140828 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50672886 CSc1cccc(Nc2ncc3cc(-c4c(Cl)cccc4Cl)c(=O)n(C)c3n2)c1 InChI=1S/C21H16Cl2N4OS/c1-27-19-12(9-15(20(27)28)18-16(22)7-4-8-17(18)23)11-24-21(26-19)25-13-5-3-6-14(10-13)29-2/h3-11H,1-2H3,(H,24,25,26) VAARYSWULJUGST-UHFFFAOYSA-N 6568 6-(2,6-dichlorophenyl)-8-methyl-2-{[3-(methylsulfanyl)phenyl]amino}-7H,8H-pyrido[2,3-d]pyrimidin-7-one::CHEMBL386051::PD-173955::PD173955::US11136333, Compound PD173955 Ribosomal protein S6 kinase alpha-3 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=6568 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=6568&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search P17 1M52,5IA3 447077 8036145 49791 CHEMBL386051 DB02567 5699 ZINC02047743 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50679971 COc1cc(ccc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1)N1CCC(CC1)N1CCN(C)CC1 InChI=1S/C30H40ClN7O3S/c1-21(2)42(39,40)28-8-6-5-7-26(28)33-29-24(31)20-32-30(35-29)34-25-10-9-23(19-27(25)41-4)37-13-11-22(12-14-37)38-17-15-36(3)16-18-38/h5-10,19-22H,11-18H2,1-4H3,(H2,32,33,34,35) QQWUGDVOUVUTOY-UHFFFAOYSA-N 482158 BDBM50242742::TAE684 Ribosomal protein S6 kinase alpha-3 Homo sapiens 17 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=482158 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=482158&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 16038120 443551321 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50681539 CCCS(=O)(=O)Nc1ccc(F)c(C(=O)c2c[nH]c3ncc(Cl)cc23)c1F InChI=1S/C17H14ClF2N3O3S/c1-2-5-27(25,26)23-13-4-3-12(19)14(15(13)20)16(24)11-8-22-17-10(11)6-9(18)7-21-17/h3-4,6-8,23H,2,5H2,1H3,(H,21,22) YZDJQTHVDDOVHR-UHFFFAOYSA-N 25617 N-[3-({5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl}carbonyl)-2,4-difluorophenyl]propane-1-sulfonamide::PLX4720 Ribosomal protein S6 kinase alpha-3 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25617 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25617&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 324 3C4C,4WO5 24180719 56412907 DB06999 5703 ZINC39059267 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50674473 Oc1cccc(c1)-c1nc(N2CCOCC2)c2oc3ncccc3c2n1 InChI=1S/C19H16N4O3/c24-13-4-1-3-12(11-13)17-21-15-14-5-2-6-20-19(14)26-16(15)18(22-17)23-7-9-25-10-8-23/h1-6,11,24H,7-10H2 TUVCWJQQGGETHL-UHFFFAOYSA-N 25045 3-(4-morpholin-4-ylpyrido[2,3]furo[2,4-b]pyrimidin-2-yl)phenol::3-(4-morpholin-4-ylpyrido[3 ,2 :4,5]furo[3,2-d]pyrimidin-2-yl)phenol::3-(4-morpholinopyrido[2,3]furo[2,4-b]pyrimidin-2-yl)phenol::3-[4-(4-morpholinyl)-2-pyrido[2,3]furo[2,4-b]pyrimidinyl]phenol::3-[6-(morpholin-4-yl)-8-oxa-3,5,10-triazatricyclo[7.4.0.0^{2,7}]trideca-1(9),2,4,6,10,12-hexaen-4-yl]phenol::CHEMBL538346::PI-103::US9637488, PI-103::cid_9884685::mTOR Inhibitor, PI103::pyridofuropyrimidine derivative, 2 Ribosomal protein S6 kinase alpha-3 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25045 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25045&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search X6K 2X6K,4L23,4JT6 9884685 56374189 CHEMBL538346 5701 ZINC03963016 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50687190 CC[C@H]1N(C2CCCC2)c2nc(Nc3ccc(cc3OC)C(=O)NC3CCN(C)CC3)ncc2N(C)C1=O InChI=1S/C28H39N7O3/c1-5-22-27(37)34(3)23-17-29-28(32-25(23)35(22)20-8-6-7-9-20)31-21-11-10-18(16-24(21)38-4)26(36)30-19-12-14-33(2)15-13-19/h10-11,16-17,19-20,22H,5-9,12-15H2,1-4H3,(H,30,36)(H,29,31,32)/t22-/m1/s1 XQVVPGYIWAGRNI-JOCHJYFZSA-N 25121 4-{[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-yl]amino}-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide::BI 2536::CHEMBL513909::US10450297, Example 300::US8598172, 5 Ribosomal protein S6 kinase alpha-3 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25121 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25121&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search R78 4OGI,6MF9,6BQQ,7K0U,2RKU,6CW0,7LAI,4O74,4PY6,4I5M,5TCM,5C8G,5VBQ,7L9G,7L9L,7N7M 11364421 56374263 CHEMBL513909 5666 ZINC13986815 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50670112 Cn1cc(C2=C(C(=O)NC2=O)c2cn(C3CCN(Cc4ccccn4)CC3)c3ccccc23)c2ccccc12 InChI=1S/C32H29N5O2/c1-35-19-25(23-9-2-4-11-27(23)35)29-30(32(39)34-31(29)38)26-20-37(28-12-5-3-10-24(26)28)22-13-16-36(17-14-22)18-21-8-6-7-15-33-21/h2-12,15,19-20,22H,13-14,16-18H2,1H3,(H,34,38,39) AXRCEOKUDYDWLF-UHFFFAOYSA-N 50128285 3-(1-Methyl-1H-indol-3-yl)-4-[1-(1-pyridin-2-ylmethyl-piperidin-4-yl)-1H-indol-3-yl]-pyrrole-2,5-dione::CHEMBL300138 Ribosomal protein S6 kinase alpha-3 Homo sapiens 87 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50128285 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50128285&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 176167 104020050 CHEMBL300138 5693 ZINC01494900 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50684539 Nc1nc(N)c2nc(-c3cccc(O)c3)c(nc2n1)-c1cccc(O)c1 InChI=1S/C18H14N6O2/c19-16-15-17(24-18(20)23-16)22-14(10-4-2-6-12(26)8-10)13(21-15)9-3-1-5-11(25)7-9/h1-8,25-26H,(H4,19,20,22,23,24) UJIAQDJKSXQLIT-UHFFFAOYSA-N 25084 3-[2,4-diamino-6-(3-hydroxyphenyl)pteridin-7-yl]phenol::JMC504279 Compound 6::TG100-115 Ribosomal protein S6 kinase alpha-3 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25084 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25084&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search B6J 5WNK 10427712 56374226 5715 ZINC06718666 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50670237 CCn1c(nc2c(ncc(OC[C@H]3CCCNC3)c12)C#CC(C)(C)O)-c1nonc1N InChI=1S/C21H27N7O3/c1-4-28-18-15(30-12-13-6-5-9-23-10-13)11-24-14(7-8-21(2,3)29)16(18)25-20(28)17-19(22)27-31-26-17/h11,13,23,29H,4-6,9-10,12H2,1-3H3,(H2,22,27)/t13-/m0/s1 KGPGFQWBCSZGEL-ZDUSSCGKSA-N 25013 4-[2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-[(3S)-piperidin-3-ylmethoxy]-1H-imidazo[4,5-c]pyridin-4-yl]-2-methylbut-3-yn-2-ol::GSK-690693::GSK690693::US10550114, Compound GSK690693 Ribosomal protein S6 kinase alpha-3 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25013 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25013&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search G93 3D0E,5U94 16725726 56374157 5196 ZINC34285211 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50674584 Cn1cc(cn1)-c1ccc2nnc(Sc3ccc4ncccc4c3)n2n1 InChI=1S/C18H13N7S/c1-24-11-13(10-20-24)16-6-7-17-21-22-18(25(17)23-16)26-14-4-5-15-12(9-14)3-2-8-19-15/h2-11H,1H3 BCZUAADEACICHN-UHFFFAOYSA-N 60589 6-{[6-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulfanyl}quinoline (4)::BDBM50355498 Ribosomal protein S6 kinase alpha-3 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=60589 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=60589&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search SX8 3DKF,3DKG 16187854 24782328 DB08584 ZINC15962404 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50676061 Cc1nc(Nc2ncc(s2)C(=O)Nc2c(C)cccc2Cl)cc(n1)N1CCN(CCO)CC1 InChI=1S/C22H26ClN7O2S/c1-14-4-3-5-16(23)20(14)28-21(32)17-13-24-22(33-17)27-18-12-19(26-15(2)25-18)30-8-6-29(7-9-30)10-11-31/h3-5,12-13,31H,6-11H2,1-2H3,(H,28,32)(H,24,25,26,27) ZBNZXTGUTAYRHI-UHFFFAOYSA-N 13216 BMS-354825::CHEMBL1421::DASATINIB::N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl)]-2-methyl-4-pyrimidinyl]amino)]-1,3-thiazole-5-carboxamide::N-(2-chloro-6-methylphenyl)-2-({6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl}amino)-1,3-thiazole-5-carboxamide::US10294227, Code Dasatinib::cid_3062316::med.21724, Compound Dasatinib Ribosomal protein S6 kinase alpha-3 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13216 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13216&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 1N1 5BVW,5OWR,6FNM,6BSD,5I9Y,2ZVA,3OCT,7ERK,3QLG,3SXR,7N9G,4XLI,3OHT,2Y6O,3LFA,4XEY,2GQG,3K54,3G5D,4QMS,5VCV,5H2U 3062316 46513626 49375 CHEMBL1421 DB01254 5678 ZINC21982951 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50685975 CC1(C)CNc2cc(NC(=O)c3cccnc3NCc3ccncc3)ccc12 InChI=1S/C22H23N5O/c1-22(2)14-26-19-12-16(5-6-18(19)22)27-21(28)17-4-3-9-24-20(17)25-13-15-7-10-23-11-8-15/h3-12,26H,13-14H2,1-2H3,(H,24,25)(H,27,28) RAHBGWKEPAQNFF-UHFFFAOYSA-N 24773 AMG 706::AMG-706::Motesanib::N-(3,3-dimethyl-1,2-dihydroindol-6-yl)-2-(pyridin-4-ylmethylamino)-3-pyridinecarboxamide::N-(3,3-dimethyl-1,2-dihydroindol-6-yl)-2-(pyridin-4-ylmethylamino)pyridine-3-carboxamide::N-(3,3-dimethyl-2,3-dihydro-1H-indol-6-yl)-2-[(pyridin-4-ylmethyl)amino]pyridine-3-carboxamide::N-(3,3-dimethylindolin-6-yl)-2-(4-pyridylmethylamino)nicotinamide::US10464902, Motesanib::cid_11667893 Ribosomal protein S6 kinase alpha-3 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=24773 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=24773&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 706 3EFL 11667893 56269724 51098 5660 ZINC18710082 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50684727 COc1cc2c(ncnc2cc1OCCCN1CCCCC1)N1CCN(CC1)C(=O)Nc1ccc(OC(C)C)cc1 InChI=1S/C31H42N6O4/c1-23(2)41-25-10-8-24(9-11-25)34-31(38)37-17-15-36(16-18-37)30-26-20-28(39-3)29(21-27(26)32-22-33-30)40-19-7-14-35-12-5-4-6-13-35/h8-11,20-23H,4-7,12-19H2,1-3H3,(H,34,38) UXXQOJXBIDBUAC-UHFFFAOYSA-N 13535 4-[6-methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin-4-yl]-N-(4-propan-2-yloxyphenyl)piperazine-1-carboxamide::4-[6-methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin-4-yl]-N-[4-(1-methylethoxy)phenyl]piperazine-1-carboxamide::4-[6-methoxy-7-[3-(1-piperidinyl)propoxy]-4-quinazolinyl]-N-(4-propan-2-yloxyphenyl)-1-piperazinecarboxamide::4-{6-methoxy-7-[3-(piperidin-1-yl)propoxy]quinazolin-4-yl}-N-[4-(propan-2-yloxy)phenyl]piperazine-1-carboxamide::CHEMBL124660::MLN-518::MLN518::N-(4-isopropoxyphenyl)-4-[6-methoxy-7-(3-piperidinopropoxy)quinazolin-4-yl]piperazine-1-carboxamide::cid_3038522 Ribosomal protein S6 kinase alpha-3 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13535 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13535&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 3038522 46513936 CHEMBL124660 DB05465 ZINC03966243 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50686030 CNC(=O)c1ccccc1Sc1ccc2c(\C=C\c3ccccn3)n[nH]c2c1 InChI=1S/C22H18N4OS/c1-23-22(27)18-7-2-3-8-21(18)28-16-10-11-17-19(25-26-20(17)14-16)12-9-15-6-4-5-13-24-15/h2-14H,1H3,(H,23,27)(H,25,26)/b12-9+ RITAVMQDGBJQJZ-FMIVXFBMSA-N 25117 AG-013736::AXITINIB::N-methyl-2-({3-[(E)-2-(pyridin-2-yl)ethenyl]-1H-indazol-6-yl}sulfanyl)benzamide::US10464902, Axitinib::US9205078, Axitinib ::US9617222, Compound A Ribosomal protein S6 kinase alpha-3 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25117 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25117&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 6450551 56374259 66910 5659 ZINC03816287 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50687713 Fc1ccc(Nc2ncnc3cc(OCCCN4CCOCC4)c(NC(=O)C=C)cc23)cc1Cl InChI=1S/C24H25ClFN5O3/c1-2-23(32)30-21-13-17-20(14-22(21)34-9-3-6-31-7-10-33-11-8-31)27-15-28-24(17)29-16-4-5-19(26)18(25)12-16/h2,4-5,12-15H,1,3,6-11H2,(H,30,32)(H,27,28,29) OMZCMEYTWSXEPZ-UHFFFAOYSA-N 4779 CHEMBL31965::CHEMBL545315::CI-1033::Canertinib::N-{4-[(3-chloro-4-fluorophenyl)amino]-7-[3-(morpholin-4-yl)propoxy]quinazolin-6-yl}prop-2-enamide::PD0183805::US10507209, Compound CI-1033::US9730934, CI-1033::cid_156414 Ribosomal protein S6 kinase alpha-3 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=4779 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=4779&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 156414 8034429 61399 CHEMBL31965CHEMBL545315 DB05424 5675 ZINC27439698 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50692032 CCN(CC)CCNC(=O)c1c(C)[nH]c(\C=C2/C(=O)Nc3ccc(F)cc23)c1C InChI=1S/C22H27FN4O2/c1-5-27(6-2)10-9-24-22(29)20-13(3)19(25-14(20)4)12-17-16-11-15(23)7-8-18(16)26-21(17)28/h7-8,11-12,25H,5-6,9-10H2,1-4H3,(H,24,29)(H,26,28)/b17-12- WINHZLLDWRZWRT-ATVHPVEESA-N 4814 CHEMBL535::N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide::N-[2-(diethylamino)ethyl]-5-{[(3Z)-5-fluoro-2-oxo-2,3-dihydro-1H-indol-3-ylidene]methyl}-2,4-dimethyl-1H-pyrrole-3-carboxamide::SU11248::SUNITINIB::SUNITINIB MALATE::US10464902, Sunitinib::US9163010, Sunitinib::US9914707, SU11248 Ribosomal protein S6 kinase alpha-3 Homo sapiens 580 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=4814 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=4814&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search B49 6NG0,4KS8,3G0F,3G0E,2Y7J,6JOK,6M11,3MIY,3TI1,4QMZ,6V0X,6NFZ,6NFY,4AGD 5329102 8034462 38940 CHEMBL535 DB01268 5713 ZINC03964325 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50674851 Cc1[nH]c(\C=C2/C(=O)Nc3ccc(F)cc23)c(C)c1C(=O)NC[C@H](O)CN1CCOCC1 InChI=1S/C23H27FN4O4/c1-13-20(10-18-17-9-15(24)3-4-19(17)27-22(18)30)26-14(2)21(13)23(31)25-11-16(29)12-28-5-7-32-8-6-28/h3-4,9-10,16,26,29H,5-8,11-12H2,1-2H3,(H,25,31)(H,27,30)/b18-10-/t16-/m0/s1 CTNPALGJUAXMMC-PMFHANACSA-N 31095 5-[(Z)-(5-fluoranyl-2-oxidanylidene-1H-indol-3-ylidene)methyl]-2,4-dimethyl-N-[(2S)-3-morpholin-4-yl-2-oxidanyl-propyl]-1H-pyrrole-3-carboxamide::5-[(Z)-(5-fluoro-2-keto-indolin-3-ylidene)methyl]-N-[(2S)-2-hydroxy-3-morpholino-propyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide::5-[(Z)-(5-fluoro-2-oxo-1H-indol-3-ylidene)methyl]-N-[(2S)-2-hydroxy-3-(4-morpholinyl)propyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide::5-[(Z)-(5-fluoro-2-oxo-1H-indol-3-ylidene)methyl]-N-[(2S)-2-hydroxy-3-morpholin-4-ylpropyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide::SU-14813::cid_10138259 Ribosomal protein S6 kinase alpha-3 Homo sapiens 2100 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31095 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31095&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 10138259 252615339 ZINC18825344 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50680551 CN(C)C\C=C\C(=O)Nc1cc2c(Nc3ccc(F)c(Cl)c3)ncnc2cc1O[C@H]1CCOC1 InChI=1S/C24H25ClFN5O3/c1-31(2)8-3-4-23(32)30-21-11-17-20(12-22(21)34-16-7-9-33-13-16)27-14-28-24(17)29-15-5-6-19(26)18(25)10-15/h3-6,10-12,14,16H,7-9,13H2,1-2H3,(H,30,32)(H,27,28,29)/b4-3+/t16-/m0/s1 ULXXDDBFHOBEHA-CWDCEQMOSA-N 50322823 (S)-N-(4-(3-chloro-4-fluorophenylamino)-7-(tetrahydrofuran-3-yloxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide::AFATINIB::CHEMBL1173655::US10085983, Compound BIBW2992::US10196365, Afatinib::US10435400, Compound BIBW2992::US9388170, Afatinib::US9890168, Compound BIBW2992::WO2022090481, Example afatinib Ribosomal protein S6 kinase alpha-3 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50322823 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50322823&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 0WM 4G5J 10184653 104144352 61390 CHEMBL1173655 DB08916 5667 ZINC03976838 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50680589 Clc1cccc(Cl)c1C(=O)Nc1cn[nH]c1C(=O)NC1CCNCC1 InChI=1S/C16H17Cl2N5O2/c17-10-2-1-3-11(18)13(10)15(24)22-12-8-20-23-14(12)16(25)21-9-4-6-19-7-5-9/h1-3,8-9,19H,4-7H2,(H,20,23)(H,21,25)(H,22,24) OVPNQJVDAFNBDN-UHFFFAOYSA-N 24654 4-N-(2,6-dichlorobenzene)-3-N-(piperidin-4-yl)-1H-pyrazole-3,4-diamido::AT7519::JMC514986 Compound 33::pyrazole diamide, 33 Ribosomal protein S6 kinase alpha-3 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=24654 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=24654&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search LZE 7AGA,2VU3 11338033 56269605 5662 ZINC16052857 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50684817 OCCn1cc(c(n1)-c1ccncc1)-c1ccc2C(CCc2c1)N=O InChI=1S/C19H18N4O2/c24-10-9-23-12-17(19(21-23)13-5-7-20-8-6-13)15-1-3-16-14(11-15)2-4-18(16)22-25/h1,3,5-8,11-12,18,24H,2,4,9-10H2 RIGIGAFKKVBACY-UHFFFAOYSA-N 25628 2-{4-[(1Z)-1-(hydroxyimino)-2,3-dihydro-1H-inden-5-yl]-3-(pyridin-4-yl)-1H-pyrazol-1-yl}ethan-1-ol::AR00341677::CHEMBL525191::GDC-0879 Ribosomal protein S6 kinase alpha-3 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25628 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25628&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 91448975 56412918 CHEMBL525191 ZINC34640412 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50687794 N#CC[C@H](C1CCCC1)n1cc(cn1)-c1ncnc2[nH]ccc12 InChI=1S/C17H18N6/c18-7-5-15(12-3-1-2-4-12)23-10-13(9-22-23)16-14-6-8-19-17(14)21-11-20-16/h6,8-12,15H,1-5H2,(H,19,20,21)/t15-/m1/s1 HFNKQEVNSGCOJV-OAHLLOKOSA-N 50355501 INCB-018424::RUXOLITINIB::RUXOLITINIB PHOSPHATE::US10112907, Example 00016::US10766894, Compound TABLE 1.1::US10875847, Compound JAKAFI::US11203595, TABLE 1.1::US11279703, TABLE 6.147 Ribosomal protein S6 kinase alpha-3 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50355501 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50355501&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search RXT 6VNK,6WTN,6VGL,4U5J,7F3G 25126798 136959525 66919 DB08877 ZINC43207851 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50670560 COCCOc1cc2ncnc(Nc3cccc(c3)C#C)c2cc1OCCOC InChI=1S/C22H23N3O4/c1-4-16-6-5-7-17(12-16)25-22-18-13-20(28-10-8-26-2)21(29-11-9-27-3)14-19(18)23-15-24-22/h1,5-7,12-15H,8-11H2,2-3H3,(H,23,24,25) AAKJLRGGTJKAMG-UHFFFAOYSA-N 5446 CHEMBL553::ERLOTINIB HYDROCHLORIDE::Erlotinib::Erotinib::N-(3-Ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine Monohydrochloride::N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine::OSI-774::Tarceva::US10189853, erlotinib::US10507209, Compound Erlotinib::US11524945, Compound Erlotinib::US9409845, Table 1, Compound 22: erlotinib::US9730934, Erlotinib::WO2022090481, Example erlotinib::cid_176870 Ribosomal protein S6 kinase alpha-3 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=5446 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=5446&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search AQ4 4HJO,6DWN,1M17 176870 8035065 114785 CHEMBL553 DB00530 4920 ZINC01546066 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50677863 Cn1cnc2c(F)c(Nc3ccc(Br)cc3Cl)c(cc12)C(=O)NOCCO InChI=1S/C17H15BrClFN4O3/c1-24-8-21-16-13(24)7-10(17(26)23-27-5-4-25)15(14(16)20)22-12-3-2-9(18)6-11(12)19/h2-3,6-8,22,25H,4-5H2,1H3,(H,23,26) CYOHGALHFOKKQC-UHFFFAOYSA-N 50355497 AZD-6244::CHEMBL1614701 Ribosomal protein S6 kinase alpha-3 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50355497 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50355497&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 3EW 4U7Z,7JUZ,7JUT,7M0T 10127622 136959521 CHEMBL1614701 ZINC31773258 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50679277 C[C@@H](Oc1cc(sc1C(N)=O)-n1cnc2ccc(CN3CCN(C)CC3)cc12)c1ccccc1C(F)(F)F InChI=1S/C27H28F3N5O2S/c1-17(19-5-3-4-6-20(19)27(28,29)30)37-23-14-24(38-25(23)26(31)36)35-16-32-21-8-7-18(13-22(21)35)15-34-11-9-33(2)10-12-34/h3-8,13-14,16-17H,9-12,15H2,1-2H3,(H2,31,36)/t17-/m1/s1 ZHJGWYRLJUCMRT-QGZVFWFLSA-N 50355500 CHEMBL1908394::US9695172, GSK461364 Ribosomal protein S6 kinase alpha-3 Homo sapiens 190 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50355500 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50355500&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 15983966 136959524 CHEMBL1908394 ZINC43154472 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50680707 C[C@@H](Oc1cc(cnc1N)-c1cnn(c1)C1CCNCC1)c1c(Cl)ccc(F)c1Cl InChI=1S/C21H22Cl2FN5O/c1-12(19-16(22)2-3-17(24)20(19)23)30-18-8-13(9-27-21(18)25)14-10-28-29(11-14)15-4-6-26-7-5-15/h2-3,8-12,15,26H,4-7H2,1H3,(H2,25,27)/t12-/m1/s1 KTEIFNKAUNYNJU-GFCCVEGCSA-N 50306682 (R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)pyridin-2-amine::3-(2,6-dichloro-3-fluorobenzyloxy)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)pyridin-2-amine::3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)pyridin-2-amine::CHEMBL601719::CRIZOTINIB::PF-2341066::US10370379, Crizotinib::US10543199, Compound Crizotinib::US10780082, Compound Crizotinib::US11059827, Compound Crizotinib::US11517561, Compound Crizotinib::US9126941, PF-2341066::US9199944, Crizotinib::US9226923, Crizotinib Ribosomal protein S6 kinase alpha-3 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50306682 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50306682&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search VGH 2YFX,5AAA,5AAC,5AAB,4ANS,4ANQ,2XP2,2WGJ,3ZBF,4C9W,6IMZ 11626560 104161043 64310 CHEMBL601719 DB08700 4903 ZINC35902489 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50682265 CC(C)(C)c1cc(NC(=O)Nc2ccc(cc2)-c2cn3c(n2)sc2cc(OCCN4CCOCC4)ccc32)no1 InChI=1S/C29H32N6O4S/c1-29(2,3)25-17-26(33-39-25)32-27(36)30-20-6-4-19(5-7-20)22-18-35-23-9-8-21(16-24(23)40-28(35)31-22)38-15-12-34-10-13-37-14-11-34/h4-9,16-18H,10-15H2,1-3H3,(H2,30,32,33,36) CVWXJKQAOSCOAB-UHFFFAOYSA-N 50300690 1-(5-Tert-Butyl-1,2-Oxazol-3-Yl)-3-(4-{7-[2-(Morpholin-4-Yl)ethoxy]imidazo[2,1-B][1,3]benzothiazol-2-Yl}phenyl)urea::AC 010220::AC 220::AC-220::AC010220::AC220::ASP-2689::CHEMBL576982::N-(5-tert-Butyl-isoxazol-3-yl)-N'-{4-[7-(2-morpholin-4-yl-ethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea::Quizartinib::Quizartinib (AC220)::US10266535, Compound AC220::US11542261, Compound quizartinib::US9216997, Quizartinib (positive compound) Ribosomal protein S6 kinase alpha-3 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50300690 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50300690&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search P30 4XUF,4RT7 24889392 104155051 CHEMBL576982 5658 ZINC43204002 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50690896 CN1CCN(CC1)c1cc(Nc2cc(C)n[nH]2)nc(Sc2ccc(NC(=O)C3CC3)cc2)n1 InChI=1S/C23H28N8OS/c1-15-13-20(29-28-15)25-19-14-21(31-11-9-30(2)10-12-31)27-23(26-19)33-18-7-5-17(6-8-18)24-22(32)16-3-4-16/h5-8,13-14,16H,3-4,9-12H2,1-2H3,(H,24,32)(H2,25,26,27,28,29) GCIKSSRWRFVXBI-UHFFFAOYSA-N 13534 CHEMBL572878::N-[4-({4-[(3-methyl-1H-pyrazol-5-yl)amino]-6-(4-methylpiperazin-1-yl)pyrimidin-2-yl}sulfanyl)phenyl]cyclopropanecarboxamide::N-[4-[[4-(4-methylpiperazino)-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl]thio]phenyl]cyclopropanecarboxamide::VX-680::VX680::cyclopropane carboxylic acid {4-[4-(4-methyl-piperazin-1-yl)-6-(5-methyl-2H-pyrazol-3-ylamino)-pyrimidin-2ylsulphanyl]-phenyl}-amide Ribosomal protein S6 kinase alpha-3 Homo sapiens 6400 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13534 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13534&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search VX6 2F4J,6GR9,6BRJ,3E5A,4ZOG,4B8M,5WNM,3AMB,4JBQ,4AF3,2XYN 5494449 46513935 CHEMBL572878 5718 ZINC03820040 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50678003 Fc1ccc(Sc2ccc3c(-c4c(Cl)cccc4Cl)c(=O)ncn3n2)c(F)c1 InChI=1S/C19H9Cl2F2N3OS/c20-11-2-1-3-12(21)17(11)18-14-5-7-16(25-26(14)9-24-19(18)27)28-15-6-4-10(22)8-13(15)23/h1-9H VEPKQEUBKLEPRA-UHFFFAOYSA-N 15244 5-(2,6-dichlorophenyl)-2-(2,4-difluorophenyl)sulfanylpyrimido[1,6-b]pyridazin-6-one::5-(2,6-dichlorophenyl)-2-[(2,4-difluorophenyl)sulfanyl]-6H-pyrimido[1,6-a]pyridazin-6-one::5-(2,6-dichlorophenyl)-2-[(2,4-difluorophenyl)thio]-6-pyrimido[1,6-b]pyridazinone::5-(2,6-dichlorophenyl)-2-[(2,4-difluorophenyl)thio]pyrimido[1,6-b]pyridazin-6-one::5-(2,6-dichlorophenyl)-9-(2,4-difluorophenyl)sulfanyl-1,3,10-triazabicyclo[4.4.0]deca-2,5,7,9-tetraen-4-one::5-[2,6-bis(chloranyl)phenyl]-2-[2,4-bis(fluoranyl)phenyl]sulfanyl-pyrimido[1,6-b]pyridazin-6-one::VX-745::VX745::cid_3038525 Ribosomal protein S6 kinase alpha-3 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=15244 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=15244&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 52P 3ZSI,3HP5,3FC1 3038525 46515551 DB07138 ZINC13493055 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50679372 CN(C)C[C@@H]1CCn2cc(C3=C(C(=O)NC3=O)c3cn(CCO1)c1ccccc31)c1ccccc21 InChI=1S/C28H28N4O3/c1-30(2)15-18-11-12-31-16-21(19-7-3-5-9-23(19)31)25-26(28(34)29-27(25)33)22-17-32(13-14-35-18)24-10-6-4-8-20(22)24/h3-10,16-18H,11-15H2,1-2H3,(H,29,33,34)/t18-/m0/s1 ZCBUQCWBWNUWSU-SFHVURJKSA-N 17055 (18S)-18-[(dimethylamino)methyl]-17-oxa-4,14,21-triazahexacyclo[19.6.1.1^{7,14}.0^{2,6}.0^{8,13}.0^{22,27}]nonacosa-1(28),2(6),7(29),8(13),9,11,22(27),23,25-nonaene-3,5-dione::(9S)-9-[(dimethylamino)methyl]-6,7,10,11-tetrahydro-9H,18H-5,21:12,17-di(metheno)dibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecine-18,20(19H)-dione::K00587a::LY 333531::LY-333531::LY333531::Ruboxistaurin::cid_153999 Ribosomal protein S6 kinase alpha-3 Homo sapiens 3600 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17055 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17055&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search LY4 2J2I,1UU3 153999 46517285 5263 ZINC03812168 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50686440 OC(=O)c1ccc(Nc2ncc3CN=C(c4cc(Cl)ccc4-c3n2)c2c(F)cccc2F)cc1 InChI=1S/C25H15ClF2N4O2/c26-15-6-9-17-18(10-15)23(21-19(27)2-1-3-20(21)28)29-11-14-12-30-25(32-22(14)17)31-16-7-4-13(5-8-16)24(33)34/h1-10,12H,11H2,(H,33,34)(H,30,31,32) HHFBDROWDBDFBR-UHFFFAOYSA-N 31093 4-[[7-[2,6-bis(fluoranyl)phenyl]-9-chloranyl-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino]benzoic acid::4-[[9-chloro-7-(2,6-difluorophenyl)-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino]benzoic acid::BDBM31832::CHEMBL259084::MLN-8054::cid_11712649 Ribosomal protein S6 kinase alpha-3 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31093 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31093&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search ZZL 2X81,5IA1,2WTW,2WTV 11712649 252615338 CHEMBL259084 5696 ZINC18825334 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50675260 CCN(CCO)CCCOc1ccc2c(Nc3cc(CC(=O)Nc4cccc(F)c4)n[nH]3)ncnc2c1 InChI=1S/C26H30FN7O3/c1-2-34(10-11-35)9-4-12-37-21-7-8-22-23(16-21)28-17-29-26(22)31-24-14-20(32-33-24)15-25(36)30-19-6-3-5-18(27)13-19/h3,5-8,13-14,16-17,35H,2,4,9-12,15H2,1H3,(H,30,36)(H2,28,29,31,32,33) QYZOGCMHVIGURT-UHFFFAOYSA-N 26300 2-{3-[(7-{3-[ethyl(2-hydroxyethyl)amino]propoxy}quinazolin-4-yl)amino]-1H-pyrazol-5-yl}-N-(3-fluorophenyl)acetamide::CHEMBL215152::cid_16007391::pyrazoloquinazoline deriv., 34 Ribosomal protein S6 kinase alpha-3 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26300 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26300&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search YJA 4C2V 16007391 56464737 CHEMBL215152 5663 ZINC16697102 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50678184 CS(=O)(=O)CCNCc1ccc(o1)-c1ccc2ncnc(Nc3ccc(OCc4cccc(F)c4)c(Cl)c3)c2c1 InChI=1S/C29H26ClFN4O4S/c1-40(36,37)12-11-32-16-23-7-10-27(39-23)20-5-8-26-24(14-20)29(34-18-33-26)35-22-6-9-28(25(30)15-22)38-17-19-3-2-4-21(31)13-19/h2-10,13-15,18,32H,11-12,16-17H2,1H3,(H,33,34,35) BCFGMOOMADDAQU-UHFFFAOYSA-N 5445 CHEMBL554::GW572016::LAPATINIB DITOSYLATE::Lapatinib::N-{3-chloro-4-[(3-fluoro-benzyl)oxy]phenyl}-6-[5-({2-(methylsulfonyl)ethyl]amino}methyl)-2-furyl]-4-quinazolinamine::N-{3-chloro-4-[(3-fluorophenyl)methoxy]phenyl}-6-(5-{[(2-methanesulfonylethyl)amino]methyl}furan-2-yl)quinazolin-4-amine::Tykerb::US10507209, Compound Lapatinib::US10822334, Compound Lapatinib::US9730934, Lapatinib ditosylate::cid_208908 Ribosomal protein S6 kinase alpha-3 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=5445 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=5445&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search FMM 1XKK,3BBT 208908 8035064 49603 CHEMBL554 DB01259 5692 ZINC01550477 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50693805 CN(c1ccc2c(C)n(C)nc2c1)c1ccnc(Nc2ccc(C)c(c2)S(N)(=O)=O)n1 InChI=1S/C21H23N7O2S/c1-13-5-6-15(11-19(13)31(22,29)30)24-21-23-10-9-20(25-21)27(3)16-7-8-17-14(2)28(4)26-18(17)12-16/h5-12H,1-4H3,(H2,22,29,30)(H,23,24,25) CUIHSIWYWATEQL-UHFFFAOYSA-N 26474 5-({4-[(2,3-dimethyl-2H-indazol-6-yl)(methyl)amino]pyrimidin-2-yl}amino)-2-methylbenzene-1-sulfonamide::GW-786034::JMC514632 Compound 13::Pazopanib::cid_10113978 Ribosomal protein S6 kinase alpha-3 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26474 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26474&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 10113978 56464911 71219 DB06589 5698 ZINC11617039 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50695289 C[C@@H]1CCN(C[C@@H]1N(C)c1ncnc2[nH]ccc12)C(=O)CC#N InChI=1S/C16H20N6O/c1-11-5-8-22(14(23)3-6-17)9-13(11)21(2)16-12-4-7-18-15(12)19-10-20-16/h4,7,10-11,13H,3,5,8-9H2,1-2H3,(H,18,19,20)/t11-,13+/m1/s1 UJLAWZDWDVHWOW-YPMHNXCESA-N 50193995 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile::3-(4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile::3-{(3R,4R)-4-methyl-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}-3-oxopropanenitrile::CHEMBL221959::CP-690550::TOFACITINIB CITRATE::Tofacitinib::Tofacitinib citrate (1)::US10112907, Example 00035::US10399979, Compound Tofacitinib::US10766894, Compound TABLE 1.20::US10875847, Compound Tofacitinib::US11078206, Example Tofacitinib::US11203595, TABLE 1.20::US11339167, Example Tofacitinib Ribosomal protein S6 kinase alpha-3 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50193995 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50193995&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search MI1 3LXK,3LXN,4OTI,3EYG,3FUP 9926791 104076339 71200 CHEMBL221959 DB08183 5677 ZINC03818808 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50697996 CCCc1cn2c(\C=N\NC(N)=N)c(nc2s1)-c1ccc(cc1)[N+]([O-])=O InChI=1S/C16H17N7O2S/c1-2-3-12-9-22-13(8-19-21-15(17)18)14(20-16(22)26-12)10-4-6-11(7-5-10)23(24)25/h4-9H,2-3H2,1H3,(H4,17,18,21)/b19-8+ JJCVDHAAXKZACQ-UFWORHAWSA-N 50355600 CHEMBL1910754 Ribosomal protein S6 kinase alpha-3 Homo sapiens 20950 ChEMBL 10.1016/j.ejmech.2011.07.001 10.7270/Q2NG4R1D 21794960 Andreani, A; Granaiola, M; Leoni, A; Locatelli, A; Morigi, R; Rambaldi, M; Varoli, L; Lannigan, D; Smith, J; Scudiero, D; Kondapaka, S; Shoemaker, RH Universit£ di Bologna http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50355600 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50355600&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 9572663 136959624 CHEMBL1910754 ZINC05883417 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50697997 Cc1cn2c(\C=N\NC(N)=N)c(nc2s1)-c1cc(Cl)sc1Cl InChI=1S/C12H10Cl2N6S2/c1-5-4-20-7(3-17-19-11(15)16)9(18-12(20)21-5)6-2-8(13)22-10(6)14/h2-4H,1H3,(H4,15,16,19)/b17-3+ JFJFKCHXPSNDCV-IJUHEHPCSA-N 50355601 CHEMBL1910755 Ribosomal protein S6 kinase alpha-3 Homo sapiens 26500 ChEMBL 10.1016/j.ejmech.2011.07.001 10.7270/Q2NG4R1D 21794960 Andreani, A; Granaiola, M; Leoni, A; Locatelli, A; Morigi, R; Rambaldi, M; Varoli, L; Lannigan, D; Smith, J; Scudiero, D; Kondapaka, S; Shoemaker, RH Universit£ di Bologna http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50355601 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50355601&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 24204554 136959625 CHEMBL1910755 ZINC29133459 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50697998 Cc1csc2nc(c(\C=N\NC(N)=N)n12)-c1ccc(Cl)c(c1)[N+]([O-])=O InChI=1S/C14H12ClN7O2S/c1-7-6-25-14-19-12(11(21(7)14)5-18-20-13(16)17)8-2-3-9(15)10(4-8)22(23)24/h2-6H,1H3,(H4,16,17,20)/b18-5+ QQDNRUFGIXEPTI-BLLMUTORSA-N 50355602 CHEMBL1910756 Ribosomal protein S6 kinase alpha-3 Homo sapiens 44800 ChEMBL 10.1016/j.ejmech.2011.07.001 10.7270/Q2NG4R1D 21794960 Andreani, A; Granaiola, M; Leoni, A; Locatelli, A; Morigi, R; Rambaldi, M; Varoli, L; Lannigan, D; Smith, J; Scudiero, D; Kondapaka, S; Shoemaker, RH Universit£ di Bologna http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50355602 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50355602&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 9572537 136959626 CHEMBL1910756 ZINC13005173 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50697999 NC(=N)N\N=C\c1c(nc2sccn12)-c1cc(Cl)sc1Cl InChI=1S/C11H8Cl2N6S2/c12-7-3-5(9(13)21-7)8-6(4-16-18-10(14)15)19-1-2-20-11(19)17-8/h1-4H,(H4,14,15,18)/b16-4+ KYILJEHHCLLGAI-AYSLTRBKSA-N 50355603 CHEMBL1910757 Ribosomal protein S6 kinase alpha-3 Homo sapiens 79000 ChEMBL 10.1016/j.ejmech.2011.07.001 10.7270/Q2NG4R1D 21794960 Andreani, A; Granaiola, M; Leoni, A; Locatelli, A; Morigi, R; Rambaldi, M; Varoli, L; Lannigan, D; Smith, J; Scudiero, D; Kondapaka, S; Shoemaker, RH Universit£ di Bologna http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50355603 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50355603&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 24204556 136959627 CHEMBL1910757 ZINC29133534 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50698000 CCc1cn2c(\C=N\NC(N)=N)c(nc2s1)-c1cc(c(Cl)cc1Cl)[N+]([O-])=O InChI=1S/C15H13Cl2N7O2S/c1-2-7-6-23-12(5-20-22-14(18)19)13(21-15(23)27-7)8-3-11(24(25)26)10(17)4-9(8)16/h3-6H,2H2,1H3,(H4,18,19,22)/b20-5+ PWGDBSVELDRAGI-DENHBWNVSA-N 50355604 CHEMBL1910758 Ribosomal protein S6 kinase alpha-3 Homo sapiens 83000 ChEMBL 10.1016/j.ejmech.2011.07.001 10.7270/Q2NG4R1D 21794960 Andreani, A; Granaiola, M; Leoni, A; Locatelli, A; Morigi, R; Rambaldi, M; Varoli, L; Lannigan, D; Smith, J; Scudiero, D; Kondapaka, S; Shoemaker, RH Universit£ di Bologna http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50355604 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50355604&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 16099330 136959628 CHEMBL1910758 ZINC35086216 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50698001 Cc1nn2c(\C=N\NC(N)=N)c(nc2s1)-c1ccc(Cl)c(c1)[N+]([O-])=O InChI=1S/C13H11ClN8O2S/c1-6-20-21-10(5-17-19-12(15)16)11(18-13(21)25-6)7-2-3-8(14)9(4-7)22(23)24/h2-5H,1H3,(H4,15,16,19)/b17-5+ RKDLLNVGUWXVIF-YAXRCOADSA-N 50355605 CHEMBL1910759 Ribosomal protein S6 kinase alpha-3 Homo sapiens 94000 ChEMBL 10.1016/j.ejmech.2011.07.001 10.7270/Q2NG4R1D 21794960 Andreani, A; Granaiola, M; Leoni, A; Locatelli, A; Morigi, R; Rambaldi, M; Varoli, L; Lannigan, D; Smith, J; Scudiero, D; Kondapaka, S; Shoemaker, RH Universit£ di Bologna http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50355605 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50355605&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 24205072 136959629 CHEMBL1910759 ZINC29133141 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50698002 Cc1sc2nc(c(\C=N\NC(N)=N)n2c1C)-c1cc(c(Cl)cc1Cl)[N+]([O-])=O InChI=1S/C15H13Cl2N7O2S/c1-6-7(2)27-15-21-13(12(23(6)15)5-20-22-14(18)19)8-3-11(24(25)26)10(17)4-9(8)16/h3-5H,1-2H3,(H4,18,19,22)/b20-5+ LISYIVBPIXBFSA-DENHBWNVSA-N 50355606 CHEMBL1910760 Ribosomal protein S6 kinase alpha-3 Homo sapiens 98500 ChEMBL 10.1016/j.ejmech.2011.07.001 10.7270/Q2NG4R1D 21794960 Andreani, A; Granaiola, M; Leoni, A; Locatelli, A; Morigi, R; Rambaldi, M; Varoli, L; Lannigan, D; Smith, J; Scudiero, D; Kondapaka, S; Shoemaker, RH Universit£ di Bologna http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50355606 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50355606&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 9572632 136959630 CHEMBL1910760 ZINC38807571 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50698003 Cc1sc2nc(c(\C=N\NC(N)=N)n2c1C)-c1cccnc1 InChI=1S/C14H15N7S/c1-8-9(2)22-14-19-12(10-4-3-5-17-6-10)11(21(8)14)7-18-20-13(15)16/h3-7H,1-2H3,(H4,15,16,20)/b18-7+ WYUAZQGCSGSFPI-CNHKJKLMSA-N 50355607 CHEMBL1910761 Ribosomal protein S6 kinase alpha-3 Homo sapiens 100000 ChEMBL 10.1016/j.ejmech.2011.07.001 10.7270/Q2NG4R1D 21794960 Andreani, A; Granaiola, M; Leoni, A; Locatelli, A; Morigi, R; Rambaldi, M; Varoli, L; Lannigan, D; Smith, J; Scudiero, D; Kondapaka, S; Shoemaker, RH Universit£ di Bologna http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50355607 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50355607&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 16099272 136959631 CHEMBL1910761 ZINC35086138 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50698004 Cc1csc2nc(c(\C=N\NC(N)=N)n12)-c1cccnc1 InChI=1S/C13H13N7S/c1-8-7-21-13-18-11(9-3-2-4-16-5-9)10(20(8)13)6-17-19-12(14)15/h2-7H,1H3,(H4,14,15,19)/b17-6+ BRAHZCVXQBSCAL-UBKPWBPPSA-N 50355608 CHEMBL1910762 Ribosomal protein S6 kinase alpha-3 Homo sapiens 100000 ChEMBL 10.1016/j.ejmech.2011.07.001 10.7270/Q2NG4R1D 21794960 Andreani, A; Granaiola, M; Leoni, A; Locatelli, A; Morigi, R; Rambaldi, M; Varoli, L; Lannigan, D; Smith, J; Scudiero, D; Kondapaka, S; Shoemaker, RH Universit£ di Bologna http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50355608 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50355608&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 16099270 136959632 CHEMBL1910762 ZINC35086136 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50698054 NC(=N)N\N=C/c1c(nc2sccn12)-c1ccc(Br)c(c1)[N+]([O-])=O InChI=1S/C13H10BrN7O2S/c14-8-2-1-7(5-9(8)21(22)23)11-10(6-17-19-12(15)16)20-3-4-24-13(20)18-11/h1-6H,(H4,15,16,19)/b17-6- UTYZCXQWQGJXFB-FMQZQXMHSA-N 50355609 CHEMBL1909651 Ribosomal protein S6 kinase alpha-3 Homo sapiens 56730 ChEMBL 10.1016/j.ejmech.2011.07.001 10.7270/Q2NG4R1D 21794960 Andreani, A; Granaiola, M; Leoni, A; Locatelli, A; Morigi, R; Rambaldi, M; Varoli, L; Lannigan, D; Smith, J; Scudiero, D; Kondapaka, S; Shoemaker, RH Universit£ di Bologna http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50355609 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50355609&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 57394413 136959633 CHEMBL1909651 ZINC73140763 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50692593 Cc1cnc(Nc2ccc(OCCN3CCCC3)cc2)nc1Nc1cccc(c1)S(=O)(=O)NC(C)(C)C InChI=1S/C27H36N6O3S/c1-20-19-28-26(30-21-10-12-23(13-11-21)36-17-16-33-14-5-6-15-33)31-25(20)29-22-8-7-9-24(18-22)37(34,35)32-27(2,3)4/h7-13,18-19,32H,5-6,14-17H2,1-4H3,(H2,28,29,30,31) JOOXLOJCABQBSG-UHFFFAOYSA-N 50332294 CHEMBL1287853::N-tert-butyl-3-(5-methyl-2-(4-(2-(pyrrolidin-1-yl)ethoxy)phenylamino)pyrimidin-4-ylamino)benzenesulfonamide::US10112907, Example 00018::US10730860, TABLE 1.3::US10766894, Compound TABLE 1.3::US11203595, TABLE 1.3::US11384069, Example T-5 Ribosomal protein S6 kinase alpha-3 Homo sapiens 8100 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50332294 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50332294&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 2TA 4OGJ,4PS5,6VNE 16722836 123111409 CHEMBL1287853 5716 ZINC19862646 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50694017 Clc1ccc(Nc2nnc(Cc3ccncc3)c3ccccc23)cc1 InChI=1S/C20H15ClN4/c21-15-5-7-16(8-6-15)23-20-18-4-2-1-3-17(18)19(24-25-20)13-14-9-11-22-12-10-14/h1-12H,13H2,(H,23,25) YCOYDOIWSSHVCK-UHFFFAOYSA-N 4851 (4-chlorophenyl)-[4-(4-pyridylmethyl)phthalazin-1-yl]amine::(A) PTK787::CGP 79787::CHEMBL101253::CHEMBL75232::N-(4-chlorophenyl)-4-(pyridin-4-ylmethyl)-1-phthalazinamine::N-(4-chlorophenyl)-4-(pyridin-4-ylmethyl)phthalazin-1-amine::PTK-787::PTK787::ZK222584::cid_151194 Ribosomal protein S6 kinase alpha-3 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=4851 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=4851&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 151194 8034494 CHEMBL75232CHEMBL101253 DB04879 6052 ZINC00007460 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50696773 COc1cc2c(Oc3ccc4[nH]c(C)cc4c3F)ncnc2cc1OCCCN1CCCC1 InChI=1S/C25H27FN4O3/c1-16-12-17-19(29-16)6-7-21(24(17)26)33-25-18-13-22(31-2)23(14-20(18)27-15-28-25)32-11-5-10-30-8-3-4-9-30/h6-7,12-15,29H,3-5,8-11H2,1-2H3 XXJWYDDUDKYVKI-UHFFFAOYSA-N 50331096 4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinazoline::CHEMBL491473::Cediranib::US10464902, Cediranib::ZD-2171 Ribosomal protein S6 kinase alpha-3 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50331096 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50331096&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 9933475 123110211 CHEMBL491473 DB04849 5664 ZINC03948085 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50694294 CN(C)CC(=O)N1CCC(CC1)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCCCC1 InChI=1S/C26H32N6O2/c1-31(2)17-24(33)32-12-10-18(11-13-32)20-8-9-23(22(14-20)19-6-4-3-5-7-19)30-26(34)25-28-16-21(15-27)29-25/h6,8-9,14,16,18H,3-5,7,10-13,17H2,1-2H3,(H,28,29)(H,30,34) GUBJNPWVIUFSTR-UHFFFAOYSA-N 50355499 CHEMBL1908395::CHEMBL1908842 Ribosomal protein S6 kinase alpha-3 Homo sapiens 440 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50355499 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50355499&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 11676971 136959523 CHEMBL1908842CHEMBL1908395 ZINC38226716 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50695881 CS(=O)c1ccc(cc1)-c1nc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1 InChI=1S/C21H16FN3OS/c1-27(26)18-8-4-16(5-9-18)21-24-19(14-2-6-17(22)7-3-14)20(25-21)15-10-12-23-13-11-15/h2-13H,1H3,(H,24,25) CDMGBJANTYXAIV-UHFFFAOYSA-N 13336 4-[4-(4-fluorophenyl)-2-(4-methanesulfinylphenyl)-1H-imidazol-5-yl]pyridine::4-[4-(4-fluorophenyl)-2-(4-methylsulfinylphenyl)-1H-imidazol-5-yl]pyridine::4-{4-(4-fluorophenyl)-2-[4-(methylsulfinyl)phenyl]-1H-imidazol-5-yl}pyridine::CHEMBL10::SB-203580::SB203580::cid_176155 Ribosomal protein S6 kinase alpha-3 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13336 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13336&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 1A9U,1PME,2EWA 176155 46513744 CHEMBL10 5269 ZINC96006137 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50695939 COc1cc(Nc2c(cnc3cc(OCCCN4CCN(C)CC4)c(OC)cc23)C#N)c(Cl)cc1Cl InChI=1S/C26H29Cl2N5O3/c1-32-6-8-33(9-7-32)5-4-10-36-25-13-21-18(11-24(25)35-3)26(17(15-29)16-30-21)31-22-14-23(34-2)20(28)12-19(22)27/h11-14,16H,4-10H2,1-3H3,(H,30,31) UBPYILGKFZZVDX-UHFFFAOYSA-N 4552 4-[(2,4-Dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methyl-1-piperazinyl)propoxy]-3-quinolinecarbonitrile::4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile::BOSUTINIB::CHEMBL288441::SKI-606 Ribosomal protein S6 kinase alpha-3 Homo sapiens 1200 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=4552 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=4552&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search DB8 6OP9,5AJQ,4MXO,4MXY,4MXX,4MXZ,3SOA,5VC3,6FDY,5I9X,3UE4,4QMN,5VCY 5328940 8034215 39112 CHEMBL288441 DB06616 5710 ZINC22448983 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50693383 COc1ccc(F)c(F)c1C(=O)c1cnc(NC2CCN(CC2)S(C)(=O)=O)nc1N InChI=1S/C18H21F2N5O4S/c1-29-13-4-3-12(19)15(20)14(13)16(26)11-9-22-18(24-17(11)21)23-10-5-7-25(8-6-10)30(2,27)28/h3-4,9-10H,5-8H2,1-2H3,(H3,21,22,23,24) JRNJNYBQQYBCLE-UHFFFAOYSA-N 12621 2,4-Diamino-5-ketopyrimidine 39::5-[(2,3-difluoro-6-methoxyphenyl)carbonyl]-2-N-(1-methanesulfonylpiperidin-4-yl)pyrimidine-2,4-diamine::R547::[4-Amino-2-(1-methanesulfonylpiperidin-4-ylamino)pyrimidin-5-yl](2,3-difluoro-6-methoxyphenyl)methanone Ribosomal protein S6 kinase alpha-3 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12621 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12621&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search LIA 2FVD 6918852 46513075 DB08094 5707 ZINC13983251 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50708795 Cc1cc(NC(=O)c2ccc3cc4C(=O)NCCCn4c3c2)on1 InChI=1S/C17H16N4O3/c1-10-7-15(24-20-10)19-16(22)12-4-3-11-8-14-17(23)18-5-2-6-21(14)13(11)9-12/h3-4,7-9H,2,5-6H2,1H3,(H,18,23)(H,19,22) SPOWSXDVDODVEW-UHFFFAOYSA-N 50360282 CHEMBL1933143::US9150577, 193 Ribosomal protein S6 kinase alpha-3 Homo sapiens 19 ChEMBL 10.1016/j.bmcl.2011.10.029 10.7270/Q2348KTR 22056746 Kirrane, TM; Boyer, SJ; Burke, J; Guo, X; Snow, RJ; Soleymanzadeh, L; Swinamer, A; Zhang, Y; Madwed, JB; Kashem, M; Kugler, S; O'Neill, MM Boehringer Ingelheim Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50360282 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50360282&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 56835180 136964344 CHEMBL1933143 ZINC73219396 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50708796 Cc1noc(NC(=O)c2ccc3cc4C(=O)NCCCn4c3c2)c1C InChI=1S/C18H18N4O3/c1-10-11(2)21-25-18(10)20-16(23)13-5-4-12-8-15-17(24)19-6-3-7-22(15)14(12)9-13/h4-5,8-9H,3,6-7H2,1-2H3,(H,19,24)(H,20,23) DTQBQXWGJKOUOS-UHFFFAOYSA-N 50360283 CHEMBL1933144 Ribosomal protein S6 kinase alpha-3 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2011.10.029 10.7270/Q2348KTR 22056746 Kirrane, TM; Boyer, SJ; Burke, J; Guo, X; Snow, RJ; Soleymanzadeh, L; Swinamer, A; Zhang, Y; Madwed, JB; Kashem, M; Kugler, S; O'Neill, MM Boehringer Ingelheim Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50360283 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50360283&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 57391812 136964345 CHEMBL1933144 ZINC73219399 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50708797 O=C(Nc1cc(no1)C1CC1)c1ccc2cc3C(=O)NCCCn3c2c1 InChI=1S/C19H18N4O3/c24-18(21-17-10-14(22-26-17)11-2-3-11)13-5-4-12-8-16-19(25)20-6-1-7-23(16)15(12)9-13/h4-5,8-11H,1-3,6-7H2,(H,20,25)(H,21,24) UJAUSTYSRUCHNY-UHFFFAOYSA-N 50360284 CHEMBL1933068::US9150577, 198 Ribosomal protein S6 kinase alpha-3 Homo sapiens 18 ChEMBL 10.1016/j.bmcl.2011.10.029 10.7270/Q2348KTR 22056746 Kirrane, TM; Boyer, SJ; Burke, J; Guo, X; Snow, RJ; Soleymanzadeh, L; Swinamer, A; Zhang, Y; Madwed, JB; Kashem, M; Kugler, S; O'Neill, MM Boehringer Ingelheim Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50360284 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50360284&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 57398752 136964346 CHEMBL1933068 ZINC73219401 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50708798 CC(C)c1cc(NC(=O)c2ccc3cc4C(=O)NCCCn4c3c2)on1 InChI=1S/C19H20N4O3/c1-11(2)14-10-17(26-22-14)21-18(24)13-5-4-12-8-16-19(25)20-6-3-7-23(16)15(12)9-13/h4-5,8-11H,3,6-7H2,1-2H3,(H,20,25)(H,21,24) JBOKTWNEIMBJNQ-UHFFFAOYSA-N 50360285 CHEMBL1933145::US9150577, 196 Ribosomal protein S6 kinase alpha-3 Homo sapiens 26 ChEMBL 10.1016/j.bmcl.2011.10.029 10.7270/Q2348KTR 22056746 Kirrane, TM; Boyer, SJ; Burke, J; Guo, X; Snow, RJ; Soleymanzadeh, L; Swinamer, A; Zhang, Y; Madwed, JB; Kashem, M; Kugler, S; O'Neill, MM Boehringer Ingelheim Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50360285 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50360285&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 57400465 136964347 CHEMBL1933145 ZINC73219404 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50708799 O=C(Nc1cc(no1)-c1ccccc1)c1ccc2cc3C(=O)NCCCn3c2c1 InChI=1S/C22H18N4O3/c27-21(24-20-13-17(25-29-20)14-5-2-1-3-6-14)16-8-7-15-11-19-22(28)23-9-4-10-26(19)18(15)12-16/h1-3,5-8,11-13H,4,9-10H2,(H,23,28)(H,24,27) UERCXNOQFSTSOY-UHFFFAOYSA-N 50360286 CHEMBL1933146::US9150577, 214 Ribosomal protein S6 kinase alpha-3 Homo sapiens 86 ChEMBL 10.1016/j.bmcl.2011.10.029 10.7270/Q2348KTR 22056746 Kirrane, TM; Boyer, SJ; Burke, J; Guo, X; Snow, RJ; Soleymanzadeh, L; Swinamer, A; Zhang, Y; Madwed, JB; Kashem, M; Kugler, S; O'Neill, MM Boehringer Ingelheim Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50360286 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50360286&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 57391813 136964348 CHEMBL1933146 ZINC73220351 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50708800 O=C(Nc1cc(Cc2ccccc2)no1)c1ccc2cc3C(=O)NCCCn3c2c1 InChI=1S/C23H20N4O3/c28-22(25-21-14-18(26-30-21)11-15-5-2-1-3-6-15)17-8-7-16-12-20-23(29)24-9-4-10-27(20)19(16)13-17/h1-3,5-8,12-14H,4,9-11H2,(H,24,29)(H,25,28) JMEYCQCGWJJILQ-UHFFFAOYSA-N 50360287 CHEMBL1933147 Ribosomal protein S6 kinase alpha-3 Homo sapiens 13 ChEMBL 10.1016/j.bmcl.2011.10.029 10.7270/Q2348KTR 22056746 Kirrane, TM; Boyer, SJ; Burke, J; Guo, X; Snow, RJ; Soleymanzadeh, L; Swinamer, A; Zhang, Y; Madwed, JB; Kashem, M; Kugler, S; O'Neill, MM Boehringer Ingelheim Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50360287 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50360287&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 57400466 136964349 CHEMBL1933147 ZINC73220354 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50708801 Cn1cc(NC(=O)c2ccc3cc4C(=O)NCCCn4c3c2)cn1 InChI=1S/C17H17N5O2/c1-21-10-13(9-19-21)20-16(23)12-4-3-11-7-15-17(24)18-5-2-6-22(15)14(11)8-12/h3-4,7-10H,2,5-6H2,1H3,(H,18,24)(H,20,23) PXRIUZVVLPVSSH-UHFFFAOYSA-N 50360288 CHEMBL1933148::US9150577, 23 Ribosomal protein S6 kinase alpha-3 Homo sapiens 11 ChEMBL 10.1016/j.bmcl.2011.10.029 10.7270/Q2348KTR 22056746 Kirrane, TM; Boyer, SJ; Burke, J; Guo, X; Snow, RJ; Soleymanzadeh, L; Swinamer, A; Zhang, Y; Madwed, JB; Kashem, M; Kugler, S; O'Neill, MM Boehringer Ingelheim Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50360288 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50360288&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 57398793 136964350 CHEMBL1933148 ZINC73220358 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50708802 O=C(Nc1cnn(CC2CCCCC2)c1)c1ccc2cc3C(=O)NCCCn3c2c1 InChI=1S/C23H27N5O2/c29-22(26-19-13-25-27(15-19)14-16-5-2-1-3-6-16)18-8-7-17-11-21-23(30)24-9-4-10-28(21)20(17)12-18/h7-8,11-13,15-16H,1-6,9-10,14H2,(H,24,30)(H,26,29) YVUHNKZPGGBYDH-UHFFFAOYSA-N 50360289 CHEMBL1933149::US9150577, 33 Ribosomal protein S6 kinase alpha-3 Homo sapiens 7 ChEMBL 10.1016/j.bmcl.2011.10.029 10.7270/Q2348KTR 22056746 Kirrane, TM; Boyer, SJ; Burke, J; Guo, X; Snow, RJ; Soleymanzadeh, L; Swinamer, A; Zhang, Y; Madwed, JB; Kashem, M; Kugler, S; O'Neill, MM Boehringer Ingelheim Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50360289 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50360289&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 57395253 136964351 CHEMBL1933149 ZINC82158244 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50708824 O=C(Nc1cnn(Cc2ccccn2)c1)c1ccc2cc3C(=O)NCCCn3c2c1 InChI=1S/C22H20N6O2/c29-21(26-18-12-25-27(14-18)13-17-4-1-2-7-23-17)16-6-5-15-10-20-22(30)24-8-3-9-28(20)19(15)11-16/h1-2,4-7,10-12,14H,3,8-9,13H2,(H,24,30)(H,26,29) RXYDOJKKUXRPAA-UHFFFAOYSA-N 50360290 CHEMBL1933277 Ribosomal protein S6 kinase alpha-3 Homo sapiens 460 ChEMBL 10.1016/j.bmcl.2011.10.029 10.7270/Q2348KTR 22056746 Kirrane, TM; Boyer, SJ; Burke, J; Guo, X; Snow, RJ; Soleymanzadeh, L; Swinamer, A; Zhang, Y; Madwed, JB; Kashem, M; Kugler, S; O'Neill, MM Boehringer Ingelheim Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50360290 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50360290&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 57398716 136964352 CHEMBL1933277 ZINC73224363 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50708825 O=C(Nc1cnn(Cc2ccncc2)c1)c1ccc2cc3C(=O)NCCCn3c2c1 InChI=1S/C22H20N6O2/c29-21(26-18-12-25-27(14-18)13-15-4-7-23-8-5-15)17-3-2-16-10-20-22(30)24-6-1-9-28(20)19(16)11-17/h2-5,7-8,10-12,14H,1,6,9,13H2,(H,24,30)(H,26,29) WKUUMSASAHOWGZ-UHFFFAOYSA-N 50360291 CHEMBL1933278::US9150577, 114 Ribosomal protein S6 kinase alpha-3 Homo sapiens 90 ChEMBL 10.1016/j.bmcl.2011.10.029 10.7270/Q2348KTR 22056746 Kirrane, TM; Boyer, SJ; Burke, J; Guo, X; Snow, RJ; Soleymanzadeh, L; Swinamer, A; Zhang, Y; Madwed, JB; Kashem, M; Kugler, S; O'Neill, MM Boehringer Ingelheim Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50360291 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50360291&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 53247560 136964353 CHEMBL1933278 ZINC73224364 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50708826 Cn1c(NC(=O)c2ccc3cc4C(=O)NCCCn4c3c2)nc2ccccc12 InChI=1S/C21H19N5O2/c1-25-16-6-3-2-5-15(16)23-21(25)24-19(27)14-8-7-13-11-18-20(28)22-9-4-10-26(18)17(13)12-14/h2-3,5-8,11-12H,4,9-10H2,1H3,(H,22,28)(H,23,24,27) WIICYVHPNFINMO-UHFFFAOYSA-N 50360292 CHEMBL1933279::US9150577, 64 Ribosomal protein S6 kinase alpha-3 Homo sapiens 200 ChEMBL 10.1016/j.bmcl.2011.10.029 10.7270/Q2348KTR 22056746 Kirrane, TM; Boyer, SJ; Burke, J; Guo, X; Snow, RJ; Soleymanzadeh, L; Swinamer, A; Zhang, Y; Madwed, JB; Kashem, M; Kugler, S; O'Neill, MM Boehringer Ingelheim Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50360292 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50360292&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 56834880 136964354 CHEMBL1933279 ZINC73224365 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50708827 CCn1c(NC(=O)c2ccc3cc4C(=O)NCCCn4c3c2)nc2ccccc12 InChI=1S/C22H21N5O2/c1-2-26-17-7-4-3-6-16(17)24-22(26)25-20(28)15-9-8-14-12-19-21(29)23-10-5-11-27(19)18(14)13-15/h3-4,6-9,12-13H,2,5,10-11H2,1H3,(H,23,29)(H,24,25,28) NRGYMIVHSWOTKI-UHFFFAOYSA-N 50360293 CHEMBL1933280::US9150577, 81 Ribosomal protein S6 kinase alpha-3 Homo sapiens 40 ChEMBL 10.1016/j.bmcl.2011.10.029 10.7270/Q2348KTR 22056746 Kirrane, TM; Boyer, SJ; Burke, J; Guo, X; Snow, RJ; Soleymanzadeh, L; Swinamer, A; Zhang, Y; Madwed, JB; Kashem, M; Kugler, S; O'Neill, MM Boehringer Ingelheim Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50360293 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50360293&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 53247439 136964355 CHEMBL1933280 ZINC73221631 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50708828 CC(C)n1c(NC(=O)c2ccc3cc4C(=O)NCCCn4c3c2)nc2ccccc12 InChI=1S/C23H23N5O2/c1-14(2)28-18-7-4-3-6-17(18)25-23(28)26-21(29)16-9-8-15-12-20-22(30)24-10-5-11-27(20)19(15)13-16/h3-4,6-9,12-14H,5,10-11H2,1-2H3,(H,24,30)(H,25,26,29) HZZNLCVNOOMGDD-UHFFFAOYSA-N 50360294 CHEMBL1933281::US9150577, 72 Ribosomal protein S6 kinase alpha-3 Homo sapiens 180 ChEMBL 10.1016/j.bmcl.2011.10.029 10.7270/Q2348KTR 22056746 Kirrane, TM; Boyer, SJ; Burke, J; Guo, X; Snow, RJ; Soleymanzadeh, L; Swinamer, A; Zhang, Y; Madwed, JB; Kashem, M; Kugler, S; O'Neill, MM Boehringer Ingelheim Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50360294 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50360294&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 57400390 136964356 CHEMBL1933281 ZINC73221634 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50708829 O=C(Nc1nc2ccccc2n1-c1ccccc1)c1ccc2cc3C(=O)NCCCn3c2c1 InChI=1S/C26H21N5O2/c32-24(18-12-11-17-15-23-25(33)27-13-6-14-30(23)22(17)16-18)29-26-28-20-9-4-5-10-21(20)31(26)19-7-2-1-3-8-19/h1-5,7-12,15-16H,6,13-14H2,(H,27,33)(H,28,29,32) YARFNYLGLQVPEB-UHFFFAOYSA-N 50360295 CHEMBL1933282::US9150577, 76 Ribosomal protein S6 kinase alpha-3 Homo sapiens 1000 ChEMBL 10.1016/j.bmcl.2011.10.029 10.7270/Q2348KTR 22056746 Kirrane, TM; Boyer, SJ; Burke, J; Guo, X; Snow, RJ; Soleymanzadeh, L; Swinamer, A; Zhang, Y; Madwed, JB; Kashem, M; Kugler, S; O'Neill, MM Boehringer Ingelheim Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50360295 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50360295&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 57400429 136964357 CHEMBL1933282 ZINC73221637 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50708830 CN(C)CCCn1c(NC(=O)c2ccc3cc4C(=O)NCCCn4c3c2)nc2ccccc12 InChI=1S/C25H28N6O2/c1-29(2)12-6-14-31-20-8-4-3-7-19(20)27-25(31)28-23(32)18-10-9-17-15-22-24(33)26-11-5-13-30(22)21(17)16-18/h3-4,7-10,15-16H,5-6,11-14H2,1-2H3,(H,26,33)(H,27,28,32) KAKNBLVUBRXYQD-UHFFFAOYSA-N 50360296 CHEMBL1933283::US9150577, 96 Ribosomal protein S6 kinase alpha-3 Homo sapiens 200 ChEMBL 10.1016/j.bmcl.2011.10.029 10.7270/Q2348KTR 22056746 Kirrane, TM; Boyer, SJ; Burke, J; Guo, X; Snow, RJ; Soleymanzadeh, L; Swinamer, A; Zhang, Y; Madwed, JB; Kashem, M; Kugler, S; O'Neill, MM Boehringer Ingelheim Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50360296 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50360296&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 57403971 136964358 CHEMBL1933283 ZINC73221640 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50708831 CCn1c(NC(=O)c2ccc3cc4C(=O)NCCCn4c3c2)nc2cc(Cl)ccc12 InChI=1S/C22H20ClN5O2/c1-2-27-17-7-6-15(23)12-16(17)25-22(27)26-20(29)14-5-4-13-10-19-21(30)24-8-3-9-28(19)18(13)11-14/h4-7,10-12H,2-3,8-9H2,1H3,(H,24,30)(H,25,26,29) GVDISXKMIUKGIP-UHFFFAOYSA-N 50360297 CHEMBL1933284 Ribosomal protein S6 kinase alpha-3 Homo sapiens 130 ChEMBL 10.1016/j.bmcl.2011.10.029 10.7270/Q2348KTR 22056746 Kirrane, TM; Boyer, SJ; Burke, J; Guo, X; Snow, RJ; Soleymanzadeh, L; Swinamer, A; Zhang, Y; Madwed, JB; Kashem, M; Kugler, S; O'Neill, MM Boehringer Ingelheim Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50360297 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50360297&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 57395227 136964359 CHEMBL1933284 ZINC73222314 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50708832 CCn1c(NC(=O)c2ccc3cc4C(=O)NCCCn4c3c2)nc2ccc(Cl)cc12 InChI=1S/C22H20ClN5O2/c1-2-27-18-12-15(23)6-7-16(18)25-22(27)26-20(29)14-5-4-13-10-19-21(30)24-8-3-9-28(19)17(13)11-14/h4-7,10-12H,2-3,8-9H2,1H3,(H,24,30)(H,25,26,29) QYLAYPRSSJNQDC-UHFFFAOYSA-N 50360298 CHEMBL1933285::US9150577, 53 Ribosomal protein S6 kinase alpha-3 Homo sapiens 90 ChEMBL 10.1016/j.bmcl.2011.10.029 10.7270/Q2348KTR 22056746 Kirrane, TM; Boyer, SJ; Burke, J; Guo, X; Snow, RJ; Soleymanzadeh, L; Swinamer, A; Zhang, Y; Madwed, JB; Kashem, M; Kugler, S; O'Neill, MM Boehringer Ingelheim Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50360298 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50360298&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 53247559 136964360 CHEMBL1933285 ZINC73222316 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50708833 CN(C)CCCn1c(NC(=O)c2ccc3cc4C(=O)NCCCn4c3c2)nc2ccc(Cl)cc12 InChI=1S/C25H27ClN6O2/c1-30(2)10-4-12-32-21-15-18(26)7-8-19(21)28-25(32)29-23(33)17-6-5-16-13-22-24(34)27-9-3-11-31(22)20(16)14-17/h5-8,13-15H,3-4,9-12H2,1-2H3,(H,27,34)(H,28,29,33) VCZQSUBZCZZLAX-UHFFFAOYSA-N 50360299 CHEMBL1933286::US9150577, 54 Ribosomal protein S6 kinase alpha-3 Homo sapiens 160 ChEMBL 10.1016/j.bmcl.2011.10.029 10.7270/Q2348KTR 22056746 Kirrane, TM; Boyer, SJ; Burke, J; Guo, X; Snow, RJ; Soleymanzadeh, L; Swinamer, A; Zhang, Y; Madwed, JB; Kashem, M; Kugler, S; O'Neill, MM Boehringer Ingelheim Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50360299 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50360299&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 57393506 136964361 CHEMBL1933286 ZINC73224075 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50708834 CCn1c(NC(=O)c2ccc3cc4C(=O)NCCCn4c3c2)nc2cccnc12 InChI=1S/C21H20N6O2/c1-2-26-18-15(5-3-8-22-18)24-21(26)25-19(28)14-7-6-13-11-17-20(29)23-9-4-10-27(17)16(13)12-14/h3,5-8,11-12H,2,4,9-10H2,1H3,(H,23,29)(H,24,25,28) WMGGYIKBPUVPFM-UHFFFAOYSA-N 50360300 CHEMBL1933287::US9150577, 105 Ribosomal protein S6 kinase alpha-3 Homo sapiens 80 ChEMBL 10.1016/j.bmcl.2011.10.029 10.7270/Q2348KTR 22056746 Kirrane, TM; Boyer, SJ; Burke, J; Guo, X; Snow, RJ; Soleymanzadeh, L; Swinamer, A; Zhang, Y; Madwed, JB; Kashem, M; Kugler, S; O'Neill, MM Boehringer Ingelheim Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50360300 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50360300&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 57400430 136964362 CHEMBL1933287 ZINC82158485 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50708835 C[C@@H]1CCNC(=O)c2cc3ccc(cc3n12)C(=O)Nc1nc2ccccc2n1CCCN(C)C InChI=1S/C26H30N6O2/c1-17-11-12-27-25(34)23-15-18-9-10-19(16-22(18)32(17)23)24(33)29-26-28-20-7-4-5-8-21(20)31(26)14-6-13-30(2)3/h4-5,7-10,15-17H,6,11-14H2,1-3H3,(H,27,34)(H,28,29,33)/t17-/m1/s1 ZHMXXVNQAFCXKK-QGZVFWFLSA-N 50360301 CHEMBL1933288::US9150577, 93 Ribosomal protein S6 kinase alpha-3 Homo sapiens 20 ChEMBL 10.1016/j.bmcl.2011.10.029 10.7270/Q2348KTR 22056746 Kirrane, TM; Boyer, SJ; Burke, J; Guo, X; Snow, RJ; Soleymanzadeh, L; Swinamer, A; Zhang, Y; Madwed, JB; Kashem, M; Kugler, S; O'Neill, MM Boehringer Ingelheim Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50360301 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50360301&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 53246941 136964363 CHEMBL1933288 ZINC82158487 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50708836 C[C@H]1CCNC(=O)c2cc3ccc(cc3n12)C(=O)Nc1nc2ccccc2n1CCCN(C)C InChI=1S/C26H30N6O2/c1-17-11-12-27-25(34)23-15-18-9-10-19(16-22(18)32(17)23)24(33)29-26-28-20-7-4-5-8-21(20)31(26)14-6-13-30(2)3/h4-5,7-10,15-17H,6,11-14H2,1-3H3,(H,27,34)(H,28,29,33)/t17-/m0/s1 ZHMXXVNQAFCXKK-KRWDZBQOSA-N 50360302 CHEMBL1933289::US9150577, 94 Ribosomal protein S6 kinase alpha-3 Homo sapiens 100 ChEMBL 10.1016/j.bmcl.2011.10.029 10.7270/Q2348KTR 22056746 Kirrane, TM; Boyer, SJ; Burke, J; Guo, X; Snow, RJ; Soleymanzadeh, L; Swinamer, A; Zhang, Y; Madwed, JB; Kashem, M; Kugler, S; O'Neill, MM Boehringer Ingelheim Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50360302 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50360302&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 53247680 136964364 CHEMBL1933289 ZINC82158489 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50708837 CN(C)CCCn1c(NC(=O)c2ccc3cc4C(=O)NCC(C)(C)Cn4c3c2)nc2ccccc12 InChI=1S/C27H32N6O2/c1-27(2)16-28-25(35)23-14-18-10-11-19(15-22(18)33(23)17-27)24(34)30-26-29-20-8-5-6-9-21(20)32(26)13-7-12-31(3)4/h5-6,8-11,14-15H,7,12-13,16-17H2,1-4H3,(H,28,35)(H,29,30,34) LQZKYXLZCLMOGP-UHFFFAOYSA-N 50360303 CHEMBL1933290::US9150577, 99 Ribosomal protein S6 kinase alpha-3 Homo sapiens 290 ChEMBL 10.1016/j.bmcl.2011.10.029 10.7270/Q2348KTR 22056746 Kirrane, TM; Boyer, SJ; Burke, J; Guo, X; Snow, RJ; Soleymanzadeh, L; Swinamer, A; Zhang, Y; Madwed, JB; Kashem, M; Kugler, S; O'Neill, MM Boehringer Ingelheim Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50360303 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50360303&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 57398759 136964365 CHEMBL1933290 ZINC82158491 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50712423 O=C(Nc1cccnc1)c1ccc2cc3C(=O)NCCCn3c2c1 InChI=1S/C18H16N4O2/c23-17(21-14-3-1-6-19-11-14)13-5-4-12-9-16-18(24)20-7-2-8-22(16)15(12)10-13/h1,3-6,9-11H,2,7-8H2,(H,20,24)(H,21,23) DUGXSNHFGBPCPM-UHFFFAOYSA-N 30298 indole-based 7-membered lactam, 23a Ribosomal protein S6 kinase alpha-3 Homo sapiens 1940 ChEMBL 10.1016/j.bmcl.2011.10.030 10.7270/Q2XW4K7N 22100312 Boyer, SJ; Burke, J; Guo, X; Kirrane, TM; Snow, RJ; Zhang, Y; Sarko, C; Soleymanzadeh, L; Swinamer, A; Westbrook, J; Dicapua, F; Padyana, A; Cogan, D; Gao, A; Xiong, Z; Madwed, JB; Kashem, M; Kugler, S; O'Neill, MM Boehringer Ingelheim Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=30298 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=30298&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 44143558 85148058 ZINC29125863 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50712424 CC1CCNC(=O)c2cc3ccc(cc3n12)C(=O)Nc1cccnc1 InChI=1S/C19H18N4O2/c1-12-6-8-21-19(25)17-9-13-4-5-14(10-16(13)23(12)17)18(24)22-15-3-2-7-20-11-15/h2-5,7,9-12H,6,8H2,1H3,(H,21,25)(H,22,24) WXEZWMNXEPCNCY-UHFFFAOYSA-N 50361835 CHEMBL1938765::US9150577, 10 Ribosomal protein S6 kinase alpha-3 Homo sapiens 890 ChEMBL 10.1016/j.bmcl.2011.10.030 10.7270/Q2XW4K7N 22100312 Boyer, SJ; Burke, J; Guo, X; Kirrane, TM; Snow, RJ; Zhang, Y; Sarko, C; Soleymanzadeh, L; Swinamer, A; Westbrook, J; Dicapua, F; Padyana, A; Cogan, D; Gao, A; Xiong, Z; Madwed, JB; Kashem, M; Kugler, S; O'Neill, MM Boehringer Ingelheim Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50361835 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50361835&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 57401161 136965897 CHEMBL1938765 ZINC73160542 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50712425 CC1CNC(=O)c2cc3ccc(cc3n2C1)C(=O)Nc1cccnc1 InChI=1S/C19H18N4O2/c1-12-9-21-19(25)17-7-13-4-5-14(8-16(13)23(17)11-12)18(24)22-15-3-2-6-20-10-15/h2-8,10,12H,9,11H2,1H3,(H,21,25)(H,22,24) PPKZBHWXZJUOKQ-UHFFFAOYSA-N 50361836 CHEMBL272096 Ribosomal protein S6 kinase alpha-3 Homo sapiens 4890 ChEMBL 10.1016/j.bmcl.2011.10.030 10.7270/Q2XW4K7N 22100312 Boyer, SJ; Burke, J; Guo, X; Kirrane, TM; Snow, RJ; Zhang, Y; Sarko, C; Soleymanzadeh, L; Swinamer, A; Westbrook, J; Dicapua, F; Padyana, A; Cogan, D; Gao, A; Xiong, Z; Madwed, JB; Kashem, M; Kugler, S; O'Neill, MM Boehringer Ingelheim Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50361836 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50361836&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 44143561 136965898 CHEMBL272096 ZINC29125802 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50712426 O=C(Nc1cccnc1)c1ccc2cc3C(=O)NCCn3c2c1 InChI=1S/C17H14N4O2/c22-16(20-13-2-1-5-18-10-13)12-4-3-11-8-15-17(23)19-6-7-21(15)14(11)9-12/h1-5,8-10H,6-7H2,(H,19,23)(H,20,22) YMFJIJWPXNXALF-UHFFFAOYSA-N 30283 indole-based 6-membered lactam, 2 Ribosomal protein S6 kinase alpha-3 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2011.10.030 10.7270/Q2XW4K7N 22100312 Boyer, SJ; Burke, J; Guo, X; Kirrane, TM; Snow, RJ; Zhang, Y; Sarko, C; Soleymanzadeh, L; Swinamer, A; Westbrook, J; Dicapua, F; Padyana, A; Cogan, D; Gao, A; Xiong, Z; Madwed, JB; Kashem, M; Kugler, S; O'Neill, MM Boehringer Ingelheim Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=30283 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=30283&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 15604675 85148043 ZINC29125342 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50712427 CC1CNC(=O)c2cc3ccc(cc3n12)C(=O)Nc1cccnc1 InChI=1S/C18H16N4O2/c1-11-9-20-18(24)16-7-12-4-5-13(8-15(12)22(11)16)17(23)21-14-3-2-6-19-10-14/h2-8,10-11H,9H2,1H3,(H,20,24)(H,21,23) NDCRHTQLZWHNTR-UHFFFAOYSA-N 50361837 CHEMBL1938774 Ribosomal protein S6 kinase alpha-3 Homo sapiens 1630 ChEMBL 10.1016/j.bmcl.2011.10.030 10.7270/Q2XW4K7N 22100312 Boyer, SJ; Burke, J; Guo, X; Kirrane, TM; Snow, RJ; Zhang, Y; Sarko, C; Soleymanzadeh, L; Swinamer, A; Westbrook, J; Dicapua, F; Padyana, A; Cogan, D; Gao, A; Xiong, Z; Madwed, JB; Kashem, M; Kugler, S; O'Neill, MM Boehringer Ingelheim Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50361837 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50361837&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 11964005 136965899 CHEMBL1938774 ZINC82158431 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50712428 CC1(C)CNC(=O)c2cc3ccc(cc3n12)C(=O)Nc1cccnc1 InChI=1S/C19H18N4O2/c1-19(2)11-21-18(25)16-8-12-5-6-13(9-15(12)23(16)19)17(24)22-14-4-3-7-20-10-14/h3-10H,11H2,1-2H3,(H,21,25)(H,22,24) DZZUEPMVAFYJPR-UHFFFAOYSA-N 50361838 CHEMBL1938775 Ribosomal protein S6 kinase alpha-3 Homo sapiens 1550 ChEMBL 10.1016/j.bmcl.2011.10.030 10.7270/Q2XW4K7N 22100312 Boyer, SJ; Burke, J; Guo, X; Kirrane, TM; Snow, RJ; Zhang, Y; Sarko, C; Soleymanzadeh, L; Swinamer, A; Westbrook, J; Dicapua, F; Padyana, A; Cogan, D; Gao, A; Xiong, Z; Madwed, JB; Kashem, M; Kugler, S; O'Neill, MM Boehringer Ingelheim Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50361838 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50361838&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 15604847 136965900 CHEMBL1938775 ZINC34604112 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50712429 C[C@@H]1NC(=O)c2cc3ccc(cc3n2[C@@H]1C)C(=O)Nc1cccnc1 InChI=1S/C19H18N4O2/c1-11-12(2)23-16-9-14(18(24)22-15-4-3-7-20-10-15)6-5-13(16)8-17(23)19(25)21-11/h3-12H,1-2H3,(H,21,25)(H,22,24)/t11-,12+/m0/s1 TUGLLILZLOHMCZ-NWDGAFQWSA-N 50361839 CHEMBL1938776 Ribosomal protein S6 kinase alpha-3 Homo sapiens 840 ChEMBL 10.1016/j.bmcl.2011.10.030 10.7270/Q2XW4K7N 22100312 Boyer, SJ; Burke, J; Guo, X; Kirrane, TM; Snow, RJ; Zhang, Y; Sarko, C; Soleymanzadeh, L; Swinamer, A; Westbrook, J; Dicapua, F; Padyana, A; Cogan, D; Gao, A; Xiong, Z; Madwed, JB; Kashem, M; Kugler, S; O'Neill, MM Boehringer Ingelheim Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50361839 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50361839&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 57390566 136965901 CHEMBL1938776 ZINC73160030 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50712430 O=C(Nc1ccccc1)c1ccc2cc3C(=O)NCCCn3c2c1 InChI=1S/C19H17N3O2/c23-18(21-15-5-2-1-3-6-15)14-8-7-13-11-17-19(24)20-9-4-10-22(17)16(13)12-14/h1-3,5-8,11-12H,4,9-10H2,(H,20,24)(H,21,23) NMSKCMQPIFOSHU-UHFFFAOYSA-N 50361840 CHEMBL1938781::US9150577, 178 Ribosomal protein S6 kinase alpha-3 Homo sapiens 1930 ChEMBL 10.1016/j.bmcl.2011.10.030 10.7270/Q2XW4K7N 22100312 Boyer, SJ; Burke, J; Guo, X; Kirrane, TM; Snow, RJ; Zhang, Y; Sarko, C; Soleymanzadeh, L; Swinamer, A; Westbrook, J; Dicapua, F; Padyana, A; Cogan, D; Gao, A; Xiong, Z; Madwed, JB; Kashem, M; Kugler, S; O'Neill, MM Boehringer Ingelheim Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50361840 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50361840&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 57392344 136965902 CHEMBL1938781 ZINC73160037 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50712431 NC(=O)c1ccccc1NC(=O)c1ccc2cc3C(=O)NCCCn3c2c1 InChI=1S/C20H18N4O3/c21-18(25)14-4-1-2-5-15(14)23-19(26)13-7-6-12-10-17-20(27)22-8-3-9-24(17)16(12)11-13/h1-2,4-7,10-11H,3,8-9H2,(H2,21,25)(H,22,27)(H,23,26) UTARVXNWFXWXPH-UHFFFAOYSA-N 50361841 CHEMBL1938786::US9150577, 215 Ribosomal protein S6 kinase alpha-3 Homo sapiens 560 ChEMBL 10.1016/j.bmcl.2011.10.030 10.7270/Q2XW4K7N 22100312 Boyer, SJ; Burke, J; Guo, X; Kirrane, TM; Snow, RJ; Zhang, Y; Sarko, C; Soleymanzadeh, L; Swinamer, A; Westbrook, J; Dicapua, F; Padyana, A; Cogan, D; Gao, A; Xiong, Z; Madwed, JB; Kashem, M; Kugler, S; O'Neill, MM Boehringer Ingelheim Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50361841 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50361841&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 57392346 136965903 CHEMBL1938786 ZINC73195805 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50712432 O=C(Nc1ccncc1)c1ccc2cc3C(=O)NCCCn3c2c1 InChI=1S/C18H16N4O2/c23-17(21-14-4-7-19-8-5-14)13-3-2-12-10-16-18(24)20-6-1-9-22(16)15(12)11-13/h2-5,7-8,10-11H,1,6,9H2,(H,20,24)(H,19,21,23) FTOWCRNOCYACIS-UHFFFAOYSA-N 50361842 CHEMBL1938787::US9150577, 156 Ribosomal protein S6 kinase alpha-3 Homo sapiens 620 ChEMBL 10.1016/j.bmcl.2011.10.030 10.7270/Q2XW4K7N 22100312 Boyer, SJ; Burke, J; Guo, X; Kirrane, TM; Snow, RJ; Zhang, Y; Sarko, C; Soleymanzadeh, L; Swinamer, A; Westbrook, J; Dicapua, F; Padyana, A; Cogan, D; Gao, A; Xiong, Z; Madwed, JB; Kashem, M; Kugler, S; O'Neill, MM Boehringer Ingelheim Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50361842 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50361842&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 57397643 136965904 CHEMBL1938787 ZINC73224765 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50712433 O=C(Nc1ccccn1)c1ccc2cc3C(=O)NCCCn3c2c1 InChI=1S/C18H16N4O2/c23-17(21-16-4-1-2-7-19-16)13-6-5-12-10-15-18(24)20-8-3-9-22(15)14(12)11-13/h1-2,4-7,10-11H,3,8-9H2,(H,20,24)(H,19,21,23) LHRDCIRKYUFYOY-UHFFFAOYSA-N 50361843 CHEMBL1938788::US9150577, 154 Ribosomal protein S6 kinase alpha-3 Homo sapiens 2630 ChEMBL 10.1016/j.bmcl.2011.10.030 10.7270/Q2XW4K7N 22100312 Boyer, SJ; Burke, J; Guo, X; Kirrane, TM; Snow, RJ; Zhang, Y; Sarko, C; Soleymanzadeh, L; Swinamer, A; Westbrook, J; Dicapua, F; Padyana, A; Cogan, D; Gao, A; Xiong, Z; Madwed, JB; Kashem, M; Kugler, S; O'Neill, MM Boehringer Ingelheim Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50361843 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50361843&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 57402839 136965905 CHEMBL1938788 ZINC73166486 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50712434 O=C(NCc1cccnc1)c1ccc2cc3C(=O)NCCCn3c2c1 InChI=1S/C19H18N4O2/c24-18(22-12-13-3-1-6-20-11-13)15-5-4-14-9-17-19(25)21-7-2-8-23(17)16(14)10-15/h1,3-6,9-11H,2,7-8,12H2,(H,21,25)(H,22,24) LGGWWYULJHBMPH-UHFFFAOYSA-N 50361844 CHEMBL1938790 Ribosomal protein S6 kinase alpha-3 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2011.10.030 10.7270/Q2XW4K7N 22100312 Boyer, SJ; Burke, J; Guo, X; Kirrane, TM; Snow, RJ; Zhang, Y; Sarko, C; Soleymanzadeh, L; Swinamer, A; Westbrook, J; Dicapua, F; Padyana, A; Cogan, D; Gao, A; Xiong, Z; Madwed, JB; Kashem, M; Kugler, S; O'Neill, MM Boehringer Ingelheim Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50361844 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50361844&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 57402840 136965906 CHEMBL1938790 ZINC73166492 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50712435 O=C(Nc1ncc[nH]1)c1ccc2cc3C(=O)NCCCn3c2c1 InChI=1S/C16H15N5O2/c22-14(20-16-18-5-6-19-16)11-3-2-10-8-13-15(23)17-4-1-7-21(13)12(10)9-11/h2-3,5-6,8-9H,1,4,7H2,(H,17,23)(H2,18,19,20,22) VSYFECVWSJTEIL-UHFFFAOYSA-N 50361845 CHEMBL1938792::US9150577, 108 Ribosomal protein S6 kinase alpha-3 Homo sapiens 290 ChEMBL 10.1016/j.bmcl.2011.10.030 10.7270/Q2XW4K7N 22100312 Boyer, SJ; Burke, J; Guo, X; Kirrane, TM; Snow, RJ; Zhang, Y; Sarko, C; Soleymanzadeh, L; Swinamer, A; Westbrook, J; Dicapua, F; Padyana, A; Cogan, D; Gao, A; Xiong, Z; Madwed, JB; Kashem, M; Kugler, S; O'Neill, MM Boehringer Ingelheim Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50361845 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50361845&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 57394085 136965907 CHEMBL1938792 ZINC73224382 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50712436 Cc1cc(NC(=O)c2ccc3cc4C(=O)NCCCn4c3c2)on1 InChI=1S/C17H16N4O3/c1-10-7-15(24-20-10)19-16(22)12-4-3-11-8-14-17(23)18-5-2-6-21(14)13(11)9-12/h3-4,7-9H,2,5-6H2,1H3,(H,18,23)(H,19,22) SPOWSXDVDODVEW-UHFFFAOYSA-N 50360282 CHEMBL1933143::US9150577, 193 Ribosomal protein S6 kinase alpha-3 Homo sapiens 200 ChEMBL 10.1016/j.bmcl.2011.10.030 10.7270/Q2XW4K7N 22100312 Boyer, SJ; Burke, J; Guo, X; Kirrane, TM; Snow, RJ; Zhang, Y; Sarko, C; Soleymanzadeh, L; Swinamer, A; Westbrook, J; Dicapua, F; Padyana, A; Cogan, D; Gao, A; Xiong, Z; Madwed, JB; Kashem, M; Kugler, S; O'Neill, MM Boehringer Ingelheim Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50360282 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50360282&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 56835180 136964344 CHEMBL1933143 ZINC73219396 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50712437 Cn1cc(NC(=O)c2ccc3cc4C(=O)NCCCn4c3c2)cn1 InChI=1S/C17H17N5O2/c1-21-10-13(9-19-21)20-16(23)12-4-3-11-7-15-17(24)18-5-2-6-22(15)14(11)8-12/h3-4,7-10H,2,5-6H2,1H3,(H,18,24)(H,20,23) PXRIUZVVLPVSSH-UHFFFAOYSA-N 50360288 CHEMBL1933148::US9150577, 23 Ribosomal protein S6 kinase alpha-3 Homo sapiens 790 ChEMBL 10.1016/j.bmcl.2011.10.030 10.7270/Q2XW4K7N 22100312 Boyer, SJ; Burke, J; Guo, X; Kirrane, TM; Snow, RJ; Zhang, Y; Sarko, C; Soleymanzadeh, L; Swinamer, A; Westbrook, J; Dicapua, F; Padyana, A; Cogan, D; Gao, A; Xiong, Z; Madwed, JB; Kashem, M; Kugler, S; O'Neill, MM Boehringer Ingelheim Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50360288 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50360288&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 57398793 136964350 CHEMBL1933148 ZINC73220358 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50712438 O=C(Nc1cn[nH]c1)c1ccc2cc3C(=O)NCCCn3c2c1 InChI=1S/C16H15N5O2/c22-15(20-12-8-18-19-9-12)11-3-2-10-6-14-16(23)17-4-1-5-21(14)13(10)7-11/h2-3,6-9H,1,4-5H2,(H,17,23)(H,18,19)(H,20,22) ULNZFQKAFXCYBO-UHFFFAOYSA-N 50361846 CHEMBL1938794::US9150577, 15 Ribosomal protein S6 kinase alpha-3 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2011.10.030 10.7270/Q2XW4K7N 22100312 Boyer, SJ; Burke, J; Guo, X; Kirrane, TM; Snow, RJ; Zhang, Y; Sarko, C; Soleymanzadeh, L; Swinamer, A; Westbrook, J; Dicapua, F; Padyana, A; Cogan, D; Gao, A; Xiong, Z; Madwed, JB; Kashem, M; Kugler, S; O'Neill, MM Boehringer Ingelheim Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50361846 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50361846&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 57397731 136965908 CHEMBL1938794 ZINC73221284 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50712439 O=C(Nc1cnc2ccccc2c1)c1ccc2cc3C(=O)NCCCn3c2c1 InChI=1S/C22H18N4O2/c27-21(25-17-10-14-4-1-2-5-18(14)24-13-17)16-7-6-15-11-20-22(28)23-8-3-9-26(20)19(15)12-16/h1-2,4-7,10-13H,3,8-9H2,(H,23,28)(H,25,27) MVRDTJDXYOJXNF-UHFFFAOYSA-N 50361847 CHEMBL1938798::US9150577, 190 Ribosomal protein S6 kinase alpha-3 Homo sapiens 340 ChEMBL 10.1016/j.bmcl.2011.10.030 10.7270/Q2XW4K7N 22100312 Boyer, SJ; Burke, J; Guo, X; Kirrane, TM; Snow, RJ; Zhang, Y; Sarko, C; Soleymanzadeh, L; Swinamer, A; Westbrook, J; Dicapua, F; Padyana, A; Cogan, D; Gao, A; Xiong, Z; Madwed, JB; Kashem, M; Kugler, S; O'Neill, MM Boehringer Ingelheim Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50361847 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50361847&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 57397732 136965909 CHEMBL1938798 ZINC73239888 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50712440 CC(C)n1ncc2cc(NC(=O)c3ccc4cc5C(=O)NCCCn5c4c3)cnc12 InChI=1S/C22H22N6O2/c1-13(2)28-20-16(11-25-28)8-17(12-24-20)26-21(29)15-5-4-14-9-19-22(30)23-6-3-7-27(19)18(14)10-15/h4-5,8-13H,3,6-7H2,1-2H3,(H,23,30)(H,26,29) CHFKZEPYDHGBQK-UHFFFAOYSA-N 50361848 CHEMBL1938799::US9150577, 19 Ribosomal protein S6 kinase alpha-3 Homo sapiens 840 ChEMBL 10.1016/j.bmcl.2011.10.030 10.7270/Q2XW4K7N 22100312 Boyer, SJ; Burke, J; Guo, X; Kirrane, TM; Snow, RJ; Zhang, Y; Sarko, C; Soleymanzadeh, L; Swinamer, A; Westbrook, J; Dicapua, F; Padyana, A; Cogan, D; Gao, A; Xiong, Z; Madwed, JB; Kashem, M; Kugler, S; O'Neill, MM Boehringer Ingelheim Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50361848 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50361848&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 57390654 136965910 CHEMBL1938799 ZINC73240555 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50712441 O=C(Nc1ccc2ccccc2n1)c1ccc2cc3C(=O)NCCCn3c2c1 InChI=1S/C22H18N4O2/c27-21(25-20-9-8-14-4-1-2-5-17(14)24-20)16-7-6-15-12-19-22(28)23-10-3-11-26(19)18(15)13-16/h1-2,4-9,12-13H,3,10-11H2,(H,23,28)(H,24,25,27) WBSLEWFFUMKPFM-UHFFFAOYSA-N 50361849 CHEMBL1938800::US9150577, 5 Ribosomal protein S6 kinase alpha-3 Homo sapiens 1130 ChEMBL 10.1016/j.bmcl.2011.10.030 10.7270/Q2XW4K7N 22100312 Boyer, SJ; Burke, J; Guo, X; Kirrane, TM; Snow, RJ; Zhang, Y; Sarko, C; Soleymanzadeh, L; Swinamer, A; Westbrook, J; Dicapua, F; Padyana, A; Cogan, D; Gao, A; Xiong, Z; Madwed, JB; Kashem, M; Kugler, S; O'Neill, MM Boehringer Ingelheim Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50361849 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50361849&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 57392456 136965911 CHEMBL1938800 ZINC73240558 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50712442 O=C(Nc1nc2ccccc2o1)c1ccc2cc3C(=O)NCCCn3c2c1 InChI=1S/C20H16N4O3/c25-18(23-20-22-14-4-1-2-5-17(14)27-20)13-7-6-12-10-16-19(26)21-8-3-9-24(16)15(12)11-13/h1-2,4-7,10-11H,3,8-9H2,(H,21,26)(H,22,23,25) XEMRFXZAJHTFCF-UHFFFAOYSA-N 50361850 CHEMBL1938802::US9150577, 112 Ribosomal protein S6 kinase alpha-3 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2011.10.030 10.7270/Q2XW4K7N 22100312 Boyer, SJ; Burke, J; Guo, X; Kirrane, TM; Snow, RJ; Zhang, Y; Sarko, C; Soleymanzadeh, L; Swinamer, A; Westbrook, J; Dicapua, F; Padyana, A; Cogan, D; Gao, A; Xiong, Z; Madwed, JB; Kashem, M; Kugler, S; O'Neill, MM Boehringer Ingelheim Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50361850 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50361850&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 57394163 136965912 CHEMBL1938802 ZINC73219797 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50712443 O=C(Nc1nc2ccccc2[nH]1)c1ccc2cc3C(=O)NCCCn3c2c1 InChI=1S/C20H17N5O2/c26-18(24-20-22-14-4-1-2-5-15(14)23-20)13-7-6-12-10-17-19(27)21-8-3-9-25(17)16(12)11-13/h1-2,4-7,10-11H,3,8-9H2,(H,21,27)(H2,22,23,24,26) TWQIEMARYWIEFU-UHFFFAOYSA-N 50361851 CHEMBL1938803::US9150577, 55 Ribosomal protein S6 kinase alpha-3 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2011.10.030 10.7270/Q2XW4K7N 22100312 Boyer, SJ; Burke, J; Guo, X; Kirrane, TM; Snow, RJ; Zhang, Y; Sarko, C; Soleymanzadeh, L; Swinamer, A; Westbrook, J; Dicapua, F; Padyana, A; Cogan, D; Gao, A; Xiong, Z; Madwed, JB; Kashem, M; Kugler, S; O'Neill, MM Boehringer Ingelheim Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50361851 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50361851&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 56834879 136965913 CHEMBL1938803 ZINC73240370 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50712444 Cn1c(NC(=O)c2ccc3cc4C(=O)NCCCn4c3c2)nc2ccccc12 InChI=1S/C21H19N5O2/c1-25-16-6-3-2-5-15(16)23-21(25)24-19(27)14-8-7-13-11-18-20(28)22-9-4-10-26(18)17(13)12-14/h2-3,5-8,11-12H,4,9-10H2,1H3,(H,22,28)(H,23,24,27) WIICYVHPNFINMO-UHFFFAOYSA-N 50360292 CHEMBL1933279::US9150577, 64 Ribosomal protein S6 kinase alpha-3 Homo sapiens 200 ChEMBL 10.1016/j.bmcl.2011.10.030 10.7270/Q2XW4K7N 22100312 Boyer, SJ; Burke, J; Guo, X; Kirrane, TM; Snow, RJ; Zhang, Y; Sarko, C; Soleymanzadeh, L; Swinamer, A; Westbrook, J; Dicapua, F; Padyana, A; Cogan, D; Gao, A; Xiong, Z; Madwed, JB; Kashem, M; Kugler, S; O'Neill, MM Boehringer Ingelheim Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50360292 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50360292&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 56834880 136964354 CHEMBL1933279 ZINC73224365 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50712445 O=C(Nc1cccnc1)c1ccc2cc3C(=O)NCCCn3c2c1 InChI=1S/C18H16N4O2/c23-17(21-14-3-1-6-19-11-14)13-5-4-12-9-16-18(24)20-7-2-8-22(16)15(12)10-13/h1,3-6,9-11H,2,7-8H2,(H,20,24)(H,21,23) DUGXSNHFGBPCPM-UHFFFAOYSA-N 30298 indole-based 7-membered lactam, 23a Ribosomal protein S6 kinase alpha-3 Homo sapiens 240 ChEMBL 10.1016/j.bmcl.2011.10.030 10.7270/Q2XW4K7N 22100312 Boyer, SJ; Burke, J; Guo, X; Kirrane, TM; Snow, RJ; Zhang, Y; Sarko, C; Soleymanzadeh, L; Swinamer, A; Westbrook, J; Dicapua, F; Padyana, A; Cogan, D; Gao, A; Xiong, Z; Madwed, JB; Kashem, M; Kugler, S; O'Neill, MM Boehringer Ingelheim Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=30298 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=30298&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 44143558 85148058 ZINC29125863 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50712446 CC1CCNC(=O)c2cc3ccc(cc3n12)C(=O)Nc1cccnc1 InChI=1S/C19H18N4O2/c1-12-6-8-21-19(25)17-9-13-4-5-14(10-16(13)23(12)17)18(24)22-15-3-2-7-20-11-15/h2-5,7,9-12H,6,8H2,1H3,(H,21,25)(H,22,24) WXEZWMNXEPCNCY-UHFFFAOYSA-N 50361835 CHEMBL1938765::US9150577, 10 Ribosomal protein S6 kinase alpha-3 Homo sapiens 41 ChEMBL 10.1016/j.bmcl.2011.10.030 10.7270/Q2XW4K7N 22100312 Boyer, SJ; Burke, J; Guo, X; Kirrane, TM; Snow, RJ; Zhang, Y; Sarko, C; Soleymanzadeh, L; Swinamer, A; Westbrook, J; Dicapua, F; Padyana, A; Cogan, D; Gao, A; Xiong, Z; Madwed, JB; Kashem, M; Kugler, S; O'Neill, MM Boehringer Ingelheim Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50361835 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50361835&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 57401161 136965897 CHEMBL1938765 ZINC73160542 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50712447 CC1CNC(=O)c2cc3ccc(cc3n2C1)C(=O)Nc1cccnc1 InChI=1S/C19H18N4O2/c1-12-9-21-19(25)17-7-13-4-5-14(8-16(13)23(17)11-12)18(24)22-15-3-2-6-20-10-15/h2-8,10,12H,9,11H2,1H3,(H,21,25)(H,22,24) PPKZBHWXZJUOKQ-UHFFFAOYSA-N 50361836 CHEMBL272096 Ribosomal protein S6 kinase alpha-3 Homo sapiens 1200 ChEMBL 10.1016/j.bmcl.2011.10.030 10.7270/Q2XW4K7N 22100312 Boyer, SJ; Burke, J; Guo, X; Kirrane, TM; Snow, RJ; Zhang, Y; Sarko, C; Soleymanzadeh, L; Swinamer, A; Westbrook, J; Dicapua, F; Padyana, A; Cogan, D; Gao, A; Xiong, Z; Madwed, JB; Kashem, M; Kugler, S; O'Neill, MM Boehringer Ingelheim Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50361836 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50361836&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 44143561 136965898 CHEMBL272096 ZINC29125802 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50712448 NCC1CNC(=O)c2cc3ccc(cc3n2C1)C(=O)Nc1cccnc1 InChI=1S/C19H19N5O2/c20-8-12-9-22-19(26)17-6-13-3-4-14(7-16(13)24(17)11-12)18(25)23-15-2-1-5-21-10-15/h1-7,10,12H,8-9,11,20H2,(H,22,26)(H,23,25) IJSFSRVZKWNWIN-UHFFFAOYSA-N 50361852 CHEMBL272309 Ribosomal protein S6 kinase alpha-3 Homo sapiens 1800 ChEMBL 10.1016/j.bmcl.2011.10.030 10.7270/Q2XW4K7N 22100312 Boyer, SJ; Burke, J; Guo, X; Kirrane, TM; Snow, RJ; Zhang, Y; Sarko, C; Soleymanzadeh, L; Swinamer, A; Westbrook, J; Dicapua, F; Padyana, A; Cogan, D; Gao, A; Xiong, Z; Madwed, JB; Kashem, M; Kugler, S; O'Neill, MM Boehringer Ingelheim Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50361852 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50361852&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 44143560 136965914 CHEMBL272309 ZINC29125806 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50712449 C[C@@H]1CNC(=O)c2cc3ccc(cc3n2[C@@H]1C)C(=O)Nc1cccnc1 InChI=1S/C20H20N4O2/c1-12-10-22-20(26)18-8-14-5-6-15(9-17(14)24(18)13(12)2)19(25)23-16-4-3-7-21-11-16/h3-9,11-13H,10H2,1-2H3,(H,22,26)(H,23,25)/t12-,13-/m1/s1 DUPMGAVJLVBVOW-CHWSQXEVSA-N 50361853 CHEMBL1938766 Ribosomal protein S6 kinase alpha-3 Homo sapiens 240 ChEMBL 10.1016/j.bmcl.2011.10.030 10.7270/Q2XW4K7N 22100312 Boyer, SJ; Burke, J; Guo, X; Kirrane, TM; Snow, RJ; Zhang, Y; Sarko, C; Soleymanzadeh, L; Swinamer, A; Westbrook, J; Dicapua, F; Padyana, A; Cogan, D; Gao, A; Xiong, Z; Madwed, JB; Kashem, M; Kugler, S; O'Neill, MM Boehringer Ingelheim Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50361853 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50361853&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 57394160 136965915 CHEMBL1938766 ZINC73169961 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50712450 C[C@@H]1CNC(=O)c2cc3ccc(cc3n2[C@H]1C)C(=O)Nc1cccnc1 InChI=1S/C20H20N4O2/c1-12-10-22-20(26)18-8-14-5-6-15(9-17(14)24(18)13(12)2)19(25)23-16-4-3-7-21-11-16/h3-9,11-13H,10H2,1-2H3,(H,22,26)(H,23,25)/t12-,13+/m1/s1 DUPMGAVJLVBVOW-OLZOCXBDSA-N 50361854 CHEMBL1938767::US9150577, 151 Ribosomal protein S6 kinase alpha-3 Homo sapiens 1100 ChEMBL 10.1016/j.bmcl.2011.10.030 10.7270/Q2XW4K7N 22100312 Boyer, SJ; Burke, J; Guo, X; Kirrane, TM; Snow, RJ; Zhang, Y; Sarko, C; Soleymanzadeh, L; Swinamer, A; Westbrook, J; Dicapua, F; Padyana, A; Cogan, D; Gao, A; Xiong, Z; Madwed, JB; Kashem, M; Kugler, S; O'Neill, MM Boehringer Ingelheim Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50361854 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50361854&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 57401162 136965916 CHEMBL1938767 ZINC73169963 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50712451 CC1(C)CNC(=O)c2cc3ccc(cc3n2C1)C(=O)Nc1cccnc1 InChI=1S/C20H20N4O2/c1-20(2)11-22-19(26)17-8-13-5-6-14(9-16(13)24(17)12-20)18(25)23-15-4-3-7-21-10-15/h3-10H,11-12H2,1-2H3,(H,22,26)(H,23,25) JYQCJFGQQMVKSU-UHFFFAOYSA-N 50361855 CHEMBL1938768::US9150577, 9 Ribosomal protein S6 kinase alpha-3 Homo sapiens 4600 ChEMBL 10.1016/j.bmcl.2011.10.030 10.7270/Q2XW4K7N 22100312 Boyer, SJ; Burke, J; Guo, X; Kirrane, TM; Snow, RJ; Zhang, Y; Sarko, C; Soleymanzadeh, L; Swinamer, A; Westbrook, J; Dicapua, F; Padyana, A; Cogan, D; Gao, A; Xiong, Z; Madwed, JB; Kashem, M; Kugler, S; O'Neill, MM Boehringer Ingelheim Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50361855 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50361855&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 57390653 136965917 CHEMBL1938768 ZINC73169965 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50712452 FC1(F)CNC(=O)c2cc3ccc(cc3n2C1)C(=O)Nc1cccnc1 InChI=1S/C18H14F2N4O2/c19-18(20)9-22-17(26)15-6-11-3-4-12(7-14(11)24(15)10-18)16(25)23-13-2-1-5-21-8-13/h1-8H,9-10H2,(H,22,26)(H,23,25) NWFVQQZCPWUVCO-UHFFFAOYSA-N 50361856 CHEMBL1938769::US9150577, 152 Ribosomal protein S6 kinase alpha-3 Homo sapiens 1700 ChEMBL 10.1016/j.bmcl.2011.10.030 10.7270/Q2XW4K7N 22100312 Boyer, SJ; Burke, J; Guo, X; Kirrane, TM; Snow, RJ; Zhang, Y; Sarko, C; Soleymanzadeh, L; Swinamer, A; Westbrook, J; Dicapua, F; Padyana, A; Cogan, D; Gao, A; Xiong, Z; Madwed, JB; Kashem, M; Kugler, S; O'Neill, MM Boehringer Ingelheim Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50361856 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50361856&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 57392455 136965918 CHEMBL1938769 ZINC73169966 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50712453 O=C(Nc1cccnc1)c1ccc2cc3C(=O)NCC4(CC4)Cn3c2c1 InChI=1S/C20H18N4O2/c25-18(23-15-2-1-7-21-10-15)14-4-3-13-8-17-19(26)22-11-20(5-6-20)12-24(17)16(13)9-14/h1-4,7-10H,5-6,11-12H2,(H,22,26)(H,23,25) FCTSFXREUIQMDP-UHFFFAOYSA-N 50361857 CHEMBL1938770::US9150577, 123 Ribosomal protein S6 kinase alpha-3 Homo sapiens 410 ChEMBL 10.1016/j.bmcl.2011.10.030 10.7270/Q2XW4K7N 22100312 Boyer, SJ; Burke, J; Guo, X; Kirrane, TM; Snow, RJ; Zhang, Y; Sarko, C; Soleymanzadeh, L; Swinamer, A; Westbrook, J; Dicapua, F; Padyana, A; Cogan, D; Gao, A; Xiong, Z; Madwed, JB; Kashem, M; Kugler, S; O'Neill, MM Boehringer Ingelheim Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50361857 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50361857&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 57394161 136965919 CHEMBL1938770 ZINC73161120 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50696387 Cn1c(Nc2ccc(cc2)C(F)(F)F)nc2cc(Oc3ccnc(c3)-c3ncc([nH]3)C(F)(F)F)ccc12 InChI=1S/C24H16F6N6O/c1-36-19-7-6-15(10-17(19)34-22(36)33-14-4-2-13(3-5-14)23(25,26)27)37-16-8-9-31-18(11-16)21-32-12-20(35-21)24(28,29)30/h2-12H,1H3,(H,32,35)(H,33,34) YABJJWZLRMPFSI-UHFFFAOYSA-N 31088 1-methyl-5-[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]pyridin-4-yl]oxy-N-[4-(trifluoromethyl)phenyl]benzimidazol-2-amine::1-methyl-5-[[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]-4-pyridinyl]oxy]-N-[4-(trifluoromethyl)phenyl]-2-benzimidazolamine::CHIR-265::[1-methyl-5-[[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]-4-pyridyl]oxy]benzimidazol-2-yl]-[4-(trifluoromethyl)phenyl]amine::cid_11656518 Ribosomal protein S6 kinase alpha-3 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31088 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31088&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 55J 5CT7 11656518 252615336 5674 ZINC18710085 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50712454 O=C(Nc1cccnc1)c1ccc2cc3C(=O)NCC4(CCC4)Cn3c2c1 InChI=1S/C21H20N4O2/c26-19(24-16-3-1-8-22-11-16)15-5-4-14-9-18-20(27)23-12-21(6-2-7-21)13-25(18)17(14)10-15/h1,3-5,8-11H,2,6-7,12-13H2,(H,23,27)(H,24,26) FKCBINRGZNFDNE-UHFFFAOYSA-N 50361858 CHEMBL1938771::US9150577, 153 Ribosomal protein S6 kinase alpha-3 Homo sapiens 3300 ChEMBL 10.1016/j.bmcl.2011.10.030 10.7270/Q2XW4K7N 22100312 Boyer, SJ; Burke, J; Guo, X; Kirrane, TM; Snow, RJ; Zhang, Y; Sarko, C; Soleymanzadeh, L; Swinamer, A; Westbrook, J; Dicapua, F; Padyana, A; Cogan, D; Gao, A; Xiong, Z; Madwed, JB; Kashem, M; Kugler, S; O'Neill, MM Boehringer Ingelheim Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50361858 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50361858&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 57394162 136965920 CHEMBL1938771 ZINC73161123 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50712455 O=C(Nc1cccnc1)c1ccc2cc3C(=O)NCC4(CCOCC4)Cn3c2c1 InChI=1S/C22H22N4O3/c27-20(25-17-2-1-7-23-12-17)16-4-3-15-10-19-21(28)24-13-22(5-8-29-9-6-22)14-26(19)18(15)11-16/h1-4,7,10-12H,5-6,8-9,13-14H2,(H,24,28)(H,25,27) DWCLLHOMFHDNPC-UHFFFAOYSA-N 50361859 CHEMBL1938772 Ribosomal protein S6 kinase alpha-3 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2011.10.030 10.7270/Q2XW4K7N 22100312 Boyer, SJ; Burke, J; Guo, X; Kirrane, TM; Snow, RJ; Zhang, Y; Sarko, C; Soleymanzadeh, L; Swinamer, A; Westbrook, J; Dicapua, F; Padyana, A; Cogan, D; Gao, A; Xiong, Z; Madwed, JB; Kashem, M; Kugler, S; O'Neill, MM Boehringer Ingelheim Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50361859 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50361859&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 57395945 136965921 CHEMBL1938772 ZINC73161127 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50712456 CC1CCn2c(cc3ccc(cc23)C(=O)Nc2cccnc2)C(=O)N1 InChI=1S/C19H18N4O2/c1-12-6-8-23-16-10-14(18(24)22-15-3-2-7-20-11-15)5-4-13(16)9-17(23)19(25)21-12/h2-5,7,9-12H,6,8H2,1H3,(H,21,25)(H,22,24) XZFONEPQWUYFHH-UHFFFAOYSA-N 50361860 CHEMBL1938773 Ribosomal protein S6 kinase alpha-3 Homo sapiens 2500 ChEMBL 10.1016/j.bmcl.2011.10.030 10.7270/Q2XW4K7N 22100312 Boyer, SJ; Burke, J; Guo, X; Kirrane, TM; Snow, RJ; Zhang, Y; Sarko, C; Soleymanzadeh, L; Swinamer, A; Westbrook, J; Dicapua, F; Padyana, A; Cogan, D; Gao, A; Xiong, Z; Madwed, JB; Kashem, M; Kugler, S; O'Neill, MM Boehringer Ingelheim Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50361860 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50361860&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 57399398 136965922 CHEMBL1938773 ZINC73161131 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50712457 O=C(Nc1cccnc1)c1ccc2cc3C(=O)NCCn3c2c1 InChI=1S/C17H14N4O2/c22-16(20-13-2-1-5-18-10-13)12-4-3-11-8-15-17(23)19-6-7-21(15)14(11)9-12/h1-5,8-10H,6-7H2,(H,19,23)(H,20,22) YMFJIJWPXNXALF-UHFFFAOYSA-N 30283 indole-based 6-membered lactam, 2 Ribosomal protein S6 kinase alpha-3 Homo sapiens 730 ChEMBL 10.1016/j.bmcl.2011.10.030 10.7270/Q2XW4K7N 22100312 Boyer, SJ; Burke, J; Guo, X; Kirrane, TM; Snow, RJ; Zhang, Y; Sarko, C; Soleymanzadeh, L; Swinamer, A; Westbrook, J; Dicapua, F; Padyana, A; Cogan, D; Gao, A; Xiong, Z; Madwed, JB; Kashem, M; Kugler, S; O'Neill, MM Boehringer Ingelheim Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=30283 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=30283&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 15604675 85148043 ZINC29125342 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50712458 CC1CNC(=O)c2cc3ccc(cc3n12)C(=O)Nc1cccnc1 InChI=1S/C18H16N4O2/c1-11-9-20-18(24)16-7-12-4-5-13(8-15(12)22(11)16)17(23)21-14-3-2-6-19-10-14/h2-8,10-11H,9H2,1H3,(H,20,24)(H,21,23) NDCRHTQLZWHNTR-UHFFFAOYSA-N 50361837 CHEMBL1938774 Ribosomal protein S6 kinase alpha-3 Homo sapiens 170 ChEMBL 10.1016/j.bmcl.2011.10.030 10.7270/Q2XW4K7N 22100312 Boyer, SJ; Burke, J; Guo, X; Kirrane, TM; Snow, RJ; Zhang, Y; Sarko, C; Soleymanzadeh, L; Swinamer, A; Westbrook, J; Dicapua, F; Padyana, A; Cogan, D; Gao, A; Xiong, Z; Madwed, JB; Kashem, M; Kugler, S; O'Neill, MM Boehringer Ingelheim Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50361837 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50361837&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 11964005 136965899 CHEMBL1938774 ZINC82158431 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50712459 CC1(C)CNC(=O)c2cc3ccc(cc3n12)C(=O)Nc1cccnc1 InChI=1S/C19H18N4O2/c1-19(2)11-21-18(25)16-8-12-5-6-13(9-15(12)23(16)19)17(24)22-14-4-3-7-20-10-14/h3-10H,11H2,1-2H3,(H,21,25)(H,22,24) DZZUEPMVAFYJPR-UHFFFAOYSA-N 50361838 CHEMBL1938775 Ribosomal protein S6 kinase alpha-3 Homo sapiens 210 ChEMBL 10.1016/j.bmcl.2011.10.030 10.7270/Q2XW4K7N 22100312 Boyer, SJ; Burke, J; Guo, X; Kirrane, TM; Snow, RJ; Zhang, Y; Sarko, C; Soleymanzadeh, L; Swinamer, A; Westbrook, J; Dicapua, F; Padyana, A; Cogan, D; Gao, A; Xiong, Z; Madwed, JB; Kashem, M; Kugler, S; O'Neill, MM Boehringer Ingelheim Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50361838 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50361838&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 15604847 136965900 CHEMBL1938775 ZINC34604112 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50712460 C[C@@H]1NC(=O)c2cc3ccc(cc3n2[C@@H]1C)C(=O)Nc1cccnc1 InChI=1S/C19H18N4O2/c1-11-12(2)23-16-9-14(18(24)22-15-4-3-7-20-10-15)6-5-13(16)8-17(23)19(25)21-11/h3-12H,1-2H3,(H,21,25)(H,22,24)/t11-,12+/m0/s1 TUGLLILZLOHMCZ-NWDGAFQWSA-N 50361839 CHEMBL1938776 Ribosomal protein S6 kinase alpha-3 Homo sapiens 45 ChEMBL 10.1016/j.bmcl.2011.10.030 10.7270/Q2XW4K7N 22100312 Boyer, SJ; Burke, J; Guo, X; Kirrane, TM; Snow, RJ; Zhang, Y; Sarko, C; Soleymanzadeh, L; Swinamer, A; Westbrook, J; Dicapua, F; Padyana, A; Cogan, D; Gao, A; Xiong, Z; Madwed, JB; Kashem, M; Kugler, S; O'Neill, MM Boehringer Ingelheim Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50361839 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50361839&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 57390566 136965901 CHEMBL1938776 ZINC73160030 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50712461 C[C@H]1NC(=O)c2cc3ccc(cc3n2[C@@H]1C)C(=O)Nc1cccnc1 InChI=1S/C19H18N4O2/c1-11-12(2)23-16-9-14(18(24)22-15-4-3-7-20-10-15)6-5-13(16)8-17(23)19(25)21-11/h3-12H,1-2H3,(H,21,25)(H,22,24)/t11-,12-/m1/s1 TUGLLILZLOHMCZ-VXGBXAGGSA-N 50361861 CHEMBL1938777 Ribosomal protein S6 kinase alpha-3 Homo sapiens 871 ChEMBL 10.1016/j.bmcl.2011.10.030 10.7270/Q2XW4K7N 22100312 Boyer, SJ; Burke, J; Guo, X; Kirrane, TM; Snow, RJ; Zhang, Y; Sarko, C; Soleymanzadeh, L; Swinamer, A; Westbrook, J; Dicapua, F; Padyana, A; Cogan, D; Gao, A; Xiong, Z; Madwed, JB; Kashem, M; Kugler, S; O'Neill, MM Boehringer Ingelheim Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50361861 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50361861&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 57399310 136965923 CHEMBL1938777 ZINC73160033 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50712462 CC1Cn2c(cc3ccc(cc23)C(=O)Nc2cccnc2)C(=O)N1 InChI=1S/C18H16N4O2/c1-11-10-22-15-8-13(17(23)21-14-3-2-6-19-9-14)5-4-12(15)7-16(22)18(24)20-11/h2-9,11H,10H2,1H3,(H,20,24)(H,21,23) ANYSOYJFYNRKSS-UHFFFAOYSA-N 50361862 CHEMBL257321 Ribosomal protein S6 kinase alpha-3 Homo sapiens 350 ChEMBL 10.1016/j.bmcl.2011.10.030 10.7270/Q2XW4K7N 22100312 Boyer, SJ; Burke, J; Guo, X; Kirrane, TM; Snow, RJ; Zhang, Y; Sarko, C; Soleymanzadeh, L; Swinamer, A; Westbrook, J; Dicapua, F; Padyana, A; Cogan, D; Gao, A; Xiong, Z; Madwed, JB; Kashem, M; Kugler, S; O'Neill, MM Boehringer Ingelheim Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50361862 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50361862&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 44143549 136965924 CHEMBL257321 ZINC29126055 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50712463 NC[C@@H]1Cn2c(cc3ccc(cc23)C(=O)Nc2cccnc2)C(=O)N1 InChI=1S/C18H17N5O2/c19-8-14-10-23-15-7-12(17(24)21-13-2-1-5-20-9-13)4-3-11(15)6-16(23)18(25)22-14/h1-7,9,14H,8,10,19H2,(H,21,24)(H,22,25)/t14-/m1/s1 MMWVUKRVNHSCOU-CQSZACIVSA-N 30284 indole-based 6-membered lactam, (R)-4a Ribosomal protein S6 kinase alpha-3 Homo sapiens 970 ChEMBL 10.1016/j.bmcl.2011.10.030 10.7270/Q2XW4K7N 22100312 Boyer, SJ; Burke, J; Guo, X; Kirrane, TM; Snow, RJ; Zhang, Y; Sarko, C; Soleymanzadeh, L; Swinamer, A; Westbrook, J; Dicapua, F; Padyana, A; Cogan, D; Gao, A; Xiong, Z; Madwed, JB; Kashem, M; Kugler, S; O'Neill, MM Boehringer Ingelheim Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=30284 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=30284&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 15604844 85148044 ZINC29125335 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50712464 O=C(NC1CCCCC1)c1ccc2cc3C(=O)NCCCn3c2c1 InChI=1S/C19H23N3O2/c23-18(21-15-5-2-1-3-6-15)14-8-7-13-11-17-19(24)20-9-4-10-22(17)16(13)12-14/h7-8,11-12,15H,1-6,9-10H2,(H,20,24)(H,21,23) ADBRSRUAYRUZRI-UHFFFAOYSA-N 50361863 CHEMBL1938780 Ribosomal protein S6 kinase alpha-3 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2011.10.030 10.7270/Q2XW4K7N 22100312 Boyer, SJ; Burke, J; Guo, X; Kirrane, TM; Snow, RJ; Zhang, Y; Sarko, C; Soleymanzadeh, L; Swinamer, A; Westbrook, J; Dicapua, F; Padyana, A; Cogan, D; Gao, A; Xiong, Z; Madwed, JB; Kashem, M; Kugler, S; O'Neill, MM Boehringer Ingelheim Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50361863 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50361863&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 57401078 136965925 CHEMBL1938780 ZINC82157531 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50712465 Clc1ccccc1NC(=O)c1ccc2cc3C(=O)NCCCn3c2c1 InChI=1S/C19H16ClN3O2/c20-14-4-1-2-5-15(14)22-18(24)13-7-6-12-10-17-19(25)21-8-3-9-23(17)16(12)11-13/h1-2,4-7,10-11H,3,8-9H2,(H,21,25)(H,22,24) AREDMWBKBLAWAL-UHFFFAOYSA-N 50361864 CHEMBL1938784::US9150577, 216 Ribosomal protein S6 kinase alpha-3 Homo sapiens 6000 ChEMBL 10.1016/j.bmcl.2011.10.030 10.7270/Q2XW4K7N 22100312 Boyer, SJ; Burke, J; Guo, X; Kirrane, TM; Snow, RJ; Zhang, Y; Sarko, C; Soleymanzadeh, L; Swinamer, A; Westbrook, J; Dicapua, F; Padyana, A; Cogan, D; Gao, A; Xiong, Z; Madwed, JB; Kashem, M; Kugler, S; O'Neill, MM Boehringer Ingelheim Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50361864 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50361864&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 57402838 136965926 CHEMBL1938784 ZINC73195803 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50712466 COc1ccccc1NC(=O)c1ccc2cc3C(=O)NCCCn3c2c1 InChI=1S/C20H19N3O3/c1-26-18-6-3-2-5-15(18)22-19(24)14-8-7-13-11-17-20(25)21-9-4-10-23(17)16(13)12-14/h2-3,5-8,11-12H,4,9-10H2,1H3,(H,21,25)(H,22,24) LUYLGHWQUPWABZ-UHFFFAOYSA-N 50361865 CHEMBL1938785::US9150577, 147 Ribosomal protein S6 kinase alpha-3 Homo sapiens 400 ChEMBL 10.1016/j.bmcl.2011.10.030 10.7270/Q2XW4K7N 22100312 Boyer, SJ; Burke, J; Guo, X; Kirrane, TM; Snow, RJ; Zhang, Y; Sarko, C; Soleymanzadeh, L; Swinamer, A; Westbrook, J; Dicapua, F; Padyana, A; Cogan, D; Gao, A; Xiong, Z; Madwed, JB; Kashem, M; Kugler, S; O'Neill, MM Boehringer Ingelheim Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50361865 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50361865&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 57392345 136965927 CHEMBL1938785 ZINC73195804 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50712467 NC(=O)c1ccccc1NC(=O)c1ccc2cc3C(=O)NCCCn3c2c1 InChI=1S/C20H18N4O3/c21-18(25)14-4-1-2-5-15(14)23-19(26)13-7-6-12-10-17-20(27)22-8-3-9-24(17)16(12)11-13/h1-2,4-7,10-11H,3,8-9H2,(H2,21,25)(H,22,27)(H,23,26) UTARVXNWFXWXPH-UHFFFAOYSA-N 50361841 CHEMBL1938786::US9150577, 215 Ribosomal protein S6 kinase alpha-3 Homo sapiens 21 ChEMBL 10.1016/j.bmcl.2011.10.030 10.7270/Q2XW4K7N 22100312 Boyer, SJ; Burke, J; Guo, X; Kirrane, TM; Snow, RJ; Zhang, Y; Sarko, C; Soleymanzadeh, L; Swinamer, A; Westbrook, J; Dicapua, F; Padyana, A; Cogan, D; Gao, A; Xiong, Z; Madwed, JB; Kashem, M; Kugler, S; O'Neill, MM Boehringer Ingelheim Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50361841 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50361841&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 57392346 136965903 CHEMBL1938786 ZINC73195805 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50712468 O=C(Nc1ccncc1)c1ccc2cc3C(=O)NCCCn3c2c1 InChI=1S/C18H16N4O2/c23-17(21-14-4-7-19-8-5-14)13-3-2-12-10-16-18(24)20-6-1-9-22(16)15(12)11-13/h2-5,7-8,10-11H,1,6,9H2,(H,20,24)(H,19,21,23) FTOWCRNOCYACIS-UHFFFAOYSA-N 50361842 CHEMBL1938787::US9150577, 156 Ribosomal protein S6 kinase alpha-3 Homo sapiens 34 ChEMBL 10.1016/j.bmcl.2011.10.030 10.7270/Q2XW4K7N 22100312 Boyer, SJ; Burke, J; Guo, X; Kirrane, TM; Snow, RJ; Zhang, Y; Sarko, C; Soleymanzadeh, L; Swinamer, A; Westbrook, J; Dicapua, F; Padyana, A; Cogan, D; Gao, A; Xiong, Z; Madwed, JB; Kashem, M; Kugler, S; O'Neill, MM Boehringer Ingelheim Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50361842 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50361842&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 57397643 136965904 CHEMBL1938787 ZINC73224765 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50712469 O=C(Nc1ccccn1)c1ccc2cc3C(=O)NCCCn3c2c1 InChI=1S/C18H16N4O2/c23-17(21-16-4-1-2-7-19-16)13-6-5-12-10-15-18(24)20-8-3-9-22(15)14(12)11-13/h1-2,4-7,10-11H,3,8-9H2,(H,20,24)(H,19,21,23) LHRDCIRKYUFYOY-UHFFFAOYSA-N 50361843 CHEMBL1938788::US9150577, 154 Ribosomal protein S6 kinase alpha-3 Homo sapiens 220 ChEMBL 10.1016/j.bmcl.2011.10.030 10.7270/Q2XW4K7N 22100312 Boyer, SJ; Burke, J; Guo, X; Kirrane, TM; Snow, RJ; Zhang, Y; Sarko, C; Soleymanzadeh, L; Swinamer, A; Westbrook, J; Dicapua, F; Padyana, A; Cogan, D; Gao, A; Xiong, Z; Madwed, JB; Kashem, M; Kugler, S; O'Neill, MM Boehringer Ingelheim Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50361843 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50361843&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 57402839 136965905 CHEMBL1938788 ZINC73166486 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50712470 O=C(Nc1ncccn1)c1ccc2cc3C(=O)NCCCn3c2c1 InChI=1S/C17H15N5O2/c23-15(21-17-19-5-1-6-20-17)12-4-3-11-9-14-16(24)18-7-2-8-22(14)13(11)10-12/h1,3-6,9-10H,2,7-8H2,(H,18,24)(H,19,20,21,23) BOKOZIKIGXFORP-UHFFFAOYSA-N 50361866 CHEMBL1938789 Ribosomal protein S6 kinase alpha-3 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2011.10.030 10.7270/Q2XW4K7N 22100312 Boyer, SJ; Burke, J; Guo, X; Kirrane, TM; Snow, RJ; Zhang, Y; Sarko, C; Soleymanzadeh, L; Swinamer, A; Westbrook, J; Dicapua, F; Padyana, A; Cogan, D; Gao, A; Xiong, Z; Madwed, JB; Kashem, M; Kugler, S; O'Neill, MM Boehringer Ingelheim Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50361866 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50361866&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 57399311 136965928 CHEMBL1938789 ZINC73166489 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50712471 O=C(NCc1cccnc1)c1ccc2cc3C(=O)NCCCn3c2c1 InChI=1S/C19H18N4O2/c24-18(22-12-13-3-1-6-20-11-13)15-5-4-14-9-17-19(25)21-7-2-8-23(17)16(14)10-15/h1,3-6,9-11H,2,7-8,12H2,(H,21,25)(H,22,24) LGGWWYULJHBMPH-UHFFFAOYSA-N 50361844 CHEMBL1938790 Ribosomal protein S6 kinase alpha-3 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2011.10.030 10.7270/Q2XW4K7N 22100312 Boyer, SJ; Burke, J; Guo, X; Kirrane, TM; Snow, RJ; Zhang, Y; Sarko, C; Soleymanzadeh, L; Swinamer, A; Westbrook, J; Dicapua, F; Padyana, A; Cogan, D; Gao, A; Xiong, Z; Madwed, JB; Kashem, M; Kugler, S; O'Neill, MM Boehringer Ingelheim Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50361844 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50361844&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 57402840 136965906 CHEMBL1938790 ZINC73166492 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50712472 O=C(Nc1cccc(c1)-c1c[nH]cn1)c1ccc2cc3C(=O)NCCCn3c2c1 InChI=1S/C22H19N5O2/c28-21(26-17-4-1-3-14(9-17)18-12-23-13-25-18)16-6-5-15-10-20-22(29)24-7-2-8-27(20)19(15)11-16/h1,3-6,9-13H,2,7-8H2,(H,23,25)(H,24,29)(H,26,28) LZAHKCVOJMJNFW-UHFFFAOYSA-N 50361867 CHEMBL1938791::US9150577, 226 Ribosomal protein S6 kinase alpha-3 Homo sapiens 52 ChEMBL 10.1016/j.bmcl.2011.10.030 10.7270/Q2XW4K7N 22100312 Boyer, SJ; Burke, J; Guo, X; Kirrane, TM; Snow, RJ; Zhang, Y; Sarko, C; Soleymanzadeh, L; Swinamer, A; Westbrook, J; Dicapua, F; Padyana, A; Cogan, D; Gao, A; Xiong, Z; Madwed, JB; Kashem, M; Kugler, S; O'Neill, MM Boehringer Ingelheim Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50361867 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50361867&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 57399312 136965929 CHEMBL1938791 ZINC73221281 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50712473 O=C(Nc1nccs1)c1ccc2cc3C(=O)NCCCn3c2c1 InChI=1S/C16H14N4O2S/c21-14(19-16-18-5-7-23-16)11-3-2-10-8-13-15(22)17-4-1-6-20(13)12(10)9-11/h2-3,5,7-9H,1,4,6H2,(H,17,22)(H,18,19,21) ADDPEEUYANAWBV-UHFFFAOYSA-N 30299 indole-based 7-membered lactam, 23b Ribosomal protein S6 kinase alpha-3 Homo sapiens 2200 ChEMBL 10.1016/j.bmcl.2011.10.030 10.7270/Q2XW4K7N 22100312 Boyer, SJ; Burke, J; Guo, X; Kirrane, TM; Snow, RJ; Zhang, Y; Sarko, C; Soleymanzadeh, L; Swinamer, A; Westbrook, J; Dicapua, F; Padyana, A; Cogan, D; Gao, A; Xiong, Z; Madwed, JB; Kashem, M; Kugler, S; O'Neill, MM Boehringer Ingelheim Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=30299 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=30299&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 44143559 85148059 ZINC29125856 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50712474 O=C(Nc1ncc[nH]1)c1ccc2cc3C(=O)NCCCn3c2c1 InChI=1S/C16H15N5O2/c22-14(20-16-18-5-6-19-16)11-3-2-10-8-13-15(23)17-4-1-7-21(13)12(10)9-11/h2-3,5-6,8-9H,1,4,7H2,(H,17,23)(H2,18,19,20,22) VSYFECVWSJTEIL-UHFFFAOYSA-N 50361845 CHEMBL1938792::US9150577, 108 Ribosomal protein S6 kinase alpha-3 Homo sapiens 26 ChEMBL 10.1016/j.bmcl.2011.10.030 10.7270/Q2XW4K7N 22100312 Boyer, SJ; Burke, J; Guo, X; Kirrane, TM; Snow, RJ; Zhang, Y; Sarko, C; Soleymanzadeh, L; Swinamer, A; Westbrook, J; Dicapua, F; Padyana, A; Cogan, D; Gao, A; Xiong, Z; Madwed, JB; Kashem, M; Kugler, S; O'Neill, MM Boehringer Ingelheim Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50361845 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50361845&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 57394085 136965907 CHEMBL1938792 ZINC73224382 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50712475 Cn1ccnc1NC(=O)c1ccc2cc3C(=O)NCCCn3c2c1 InChI=1S/C17H17N5O2/c1-21-8-6-19-17(21)20-15(23)12-4-3-11-9-14-16(24)18-5-2-7-22(14)13(11)10-12/h3-4,6,8-10H,2,5,7H2,1H3,(H,18,24)(H,19,20,23) DSWMSTKGXHDPPR-UHFFFAOYSA-N 50361868 CHEMBL1938793::US9150577, 109 Ribosomal protein S6 kinase alpha-3 Homo sapiens 2200 ChEMBL 10.1016/j.bmcl.2011.10.030 10.7270/Q2XW4K7N 22100312 Boyer, SJ; Burke, J; Guo, X; Kirrane, TM; Snow, RJ; Zhang, Y; Sarko, C; Soleymanzadeh, L; Swinamer, A; Westbrook, J; Dicapua, F; Padyana, A; Cogan, D; Gao, A; Xiong, Z; Madwed, JB; Kashem, M; Kugler, S; O'Neill, MM Boehringer Ingelheim Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50361868 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50361868&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 57397644 136965930 CHEMBL1938793 ZINC73222912 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50712476 Cc1cc(NC(=O)c2ccc3cc4C(=O)NCCCn4c3c2)on1 InChI=1S/C17H16N4O3/c1-10-7-15(24-20-10)19-16(22)12-4-3-11-8-14-17(23)18-5-2-6-21(14)13(11)9-12/h3-4,7-9H,2,5-6H2,1H3,(H,18,23)(H,19,22) SPOWSXDVDODVEW-UHFFFAOYSA-N 50360282 CHEMBL1933143::US9150577, 193 Ribosomal protein S6 kinase alpha-3 Homo sapiens 19 ChEMBL 10.1016/j.bmcl.2011.10.030 10.7270/Q2XW4K7N 22100312 Boyer, SJ; Burke, J; Guo, X; Kirrane, TM; Snow, RJ; Zhang, Y; Sarko, C; Soleymanzadeh, L; Swinamer, A; Westbrook, J; Dicapua, F; Padyana, A; Cogan, D; Gao, A; Xiong, Z; Madwed, JB; Kashem, M; Kugler, S; O'Neill, MM Boehringer Ingelheim Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50360282 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50360282&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 56835180 136964344 CHEMBL1933143 ZINC73219396 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50712477 Cn1cc(NC(=O)c2ccc3cc4C(=O)NCCCn4c3c2)cn1 InChI=1S/C17H17N5O2/c1-21-10-13(9-19-21)20-16(23)12-4-3-11-7-15-17(24)18-5-2-6-22(15)14(11)8-12/h3-4,7-10H,2,5-6H2,1H3,(H,18,24)(H,20,23) PXRIUZVVLPVSSH-UHFFFAOYSA-N 50360288 CHEMBL1933148::US9150577, 23 Ribosomal protein S6 kinase alpha-3 Homo sapiens 11 ChEMBL 10.1016/j.bmcl.2011.10.030 10.7270/Q2XW4K7N 22100312 Boyer, SJ; Burke, J; Guo, X; Kirrane, TM; Snow, RJ; Zhang, Y; Sarko, C; Soleymanzadeh, L; Swinamer, A; Westbrook, J; Dicapua, F; Padyana, A; Cogan, D; Gao, A; Xiong, Z; Madwed, JB; Kashem, M; Kugler, S; O'Neill, MM Boehringer Ingelheim Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50360288 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50360288&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 57398793 136964350 CHEMBL1933148 ZINC73220358 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50712478 O=C(Nc1cn[nH]c1)c1ccc2cc3C(=O)NCCCn3c2c1 InChI=1S/C16H15N5O2/c22-15(20-12-8-18-19-9-12)11-3-2-10-6-14-16(23)17-4-1-5-21(14)13(10)7-11/h2-3,6-9H,1,4-5H2,(H,17,23)(H,18,19)(H,20,22) ULNZFQKAFXCYBO-UHFFFAOYSA-N 50361846 CHEMBL1938794::US9150577, 15 Ribosomal protein S6 kinase alpha-3 Homo sapiens 43 ChEMBL 10.1016/j.bmcl.2011.10.030 10.7270/Q2XW4K7N 22100312 Boyer, SJ; Burke, J; Guo, X; Kirrane, TM; Snow, RJ; Zhang, Y; Sarko, C; Soleymanzadeh, L; Swinamer, A; Westbrook, J; Dicapua, F; Padyana, A; Cogan, D; Gao, A; Xiong, Z; Madwed, JB; Kashem, M; Kugler, S; O'Neill, MM Boehringer Ingelheim Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50361846 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50361846&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 57397731 136965908 CHEMBL1938794 ZINC73221284 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50712479 Cn1ccc(NC(=O)c2ccc3cc4C(=O)NCCCn4c3c2)n1 InChI=1S/C17H17N5O2/c1-21-8-5-15(20-21)19-16(23)12-4-3-11-9-14-17(24)18-6-2-7-22(14)13(11)10-12/h3-5,8-10H,2,6-7H2,1H3,(H,18,24)(H,19,20,23) BGACUNRYWOIUJH-UHFFFAOYSA-N 50361869 CHEMBL1938795::US9150577, 11 Ribosomal protein S6 kinase alpha-3 Homo sapiens 540 ChEMBL 10.1016/j.bmcl.2011.10.030 10.7270/Q2XW4K7N 22100312 Boyer, SJ; Burke, J; Guo, X; Kirrane, TM; Snow, RJ; Zhang, Y; Sarko, C; Soleymanzadeh, L; Swinamer, A; Westbrook, J; Dicapua, F; Padyana, A; Cogan, D; Gao, A; Xiong, Z; Madwed, JB; Kashem, M; Kugler, S; O'Neill, MM Boehringer Ingelheim Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50361869 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50361869&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 57399399 136965931 CHEMBL1938795 ZINC73239878 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50712480 O=C(Nc1ccn[nH]1)c1ccc2cc3C(=O)NCCCn3c2c1 InChI=1S/C16H15N5O2/c22-15(19-14-4-6-18-20-14)11-3-2-10-8-13-16(23)17-5-1-7-21(13)12(10)9-11/h2-4,6,8-9H,1,5,7H2,(H,17,23)(H2,18,19,20,22) CPDJVFPDCVMFHF-UHFFFAOYSA-N 50361870 CHEMBL1938796 Ribosomal protein S6 kinase alpha-3 Homo sapiens 93 ChEMBL 10.1016/j.bmcl.2011.10.030 10.7270/Q2XW4K7N 22100312 Boyer, SJ; Burke, J; Guo, X; Kirrane, TM; Snow, RJ; Zhang, Y; Sarko, C; Soleymanzadeh, L; Swinamer, A; Westbrook, J; Dicapua, F; Padyana, A; Cogan, D; Gao, A; Xiong, Z; Madwed, JB; Kashem, M; Kugler, S; O'Neill, MM Boehringer Ingelheim Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50361870 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50361870&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 57401163 136965932 CHEMBL1938796 ZINC73239881 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50712481 Cn1nccc1NC(=O)c1ccc2cc3C(=O)NCCCn3c2c1 InChI=1S/C17H17N5O2/c1-21-15(5-7-19-21)20-16(23)12-4-3-11-9-14-17(24)18-6-2-8-22(14)13(11)10-12/h3-5,7,9-10H,2,6,8H2,1H3,(H,18,24)(H,20,23) MTSWWHLNSFSAAG-UHFFFAOYSA-N 50361871 CHEMBL1938797 Ribosomal protein S6 kinase alpha-3 Homo sapiens >1000 ChEMBL 10.1016/j.bmcl.2011.10.030 10.7270/Q2XW4K7N 22100312 Boyer, SJ; Burke, J; Guo, X; Kirrane, TM; Snow, RJ; Zhang, Y; Sarko, C; Soleymanzadeh, L; Swinamer, A; Westbrook, J; Dicapua, F; Padyana, A; Cogan, D; Gao, A; Xiong, Z; Madwed, JB; Kashem, M; Kugler, S; O'Neill, MM Boehringer Ingelheim Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50361871 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50361871&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 57402925 136965933 CHEMBL1938797 ZINC73239883 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50712482 O=C(Nc1cnc2ccccc2c1)c1ccc2cc3C(=O)NCCCn3c2c1 InChI=1S/C22H18N4O2/c27-21(25-17-10-14-4-1-2-5-18(14)24-13-17)16-7-6-15-11-20-22(28)23-8-3-9-26(20)19(15)12-16/h1-2,4-7,10-13H,3,8-9H2,(H,23,28)(H,25,27) MVRDTJDXYOJXNF-UHFFFAOYSA-N 50361847 CHEMBL1938798::US9150577, 190 Ribosomal protein S6 kinase alpha-3 Homo sapiens 34 ChEMBL 10.1016/j.bmcl.2011.10.030 10.7270/Q2XW4K7N 22100312 Boyer, SJ; Burke, J; Guo, X; Kirrane, TM; Snow, RJ; Zhang, Y; Sarko, C; Soleymanzadeh, L; Swinamer, A; Westbrook, J; Dicapua, F; Padyana, A; Cogan, D; Gao, A; Xiong, Z; Madwed, JB; Kashem, M; Kugler, S; O'Neill, MM Boehringer Ingelheim Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50361847 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50361847&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 57397732 136965909 CHEMBL1938798 ZINC73239888 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50712483 CC(C)n1ncc2cc(NC(=O)c3ccc4cc5C(=O)NCCCn5c4c3)cnc12 InChI=1S/C22H22N6O2/c1-13(2)28-20-16(11-25-28)8-17(12-24-20)26-21(29)15-5-4-14-9-19-22(30)23-6-3-7-27(19)18(14)10-15/h4-5,8-13H,3,6-7H2,1-2H3,(H,23,30)(H,26,29) CHFKZEPYDHGBQK-UHFFFAOYSA-N 50361848 CHEMBL1938799::US9150577, 19 Ribosomal protein S6 kinase alpha-3 Homo sapiens 53 ChEMBL 10.1016/j.bmcl.2011.10.030 10.7270/Q2XW4K7N 22100312 Boyer, SJ; Burke, J; Guo, X; Kirrane, TM; Snow, RJ; Zhang, Y; Sarko, C; Soleymanzadeh, L; Swinamer, A; Westbrook, J; Dicapua, F; Padyana, A; Cogan, D; Gao, A; Xiong, Z; Madwed, JB; Kashem, M; Kugler, S; O'Neill, MM Boehringer Ingelheim Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50361848 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50361848&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 57390654 136965910 CHEMBL1938799 ZINC73240555 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50712484 O=C(Nc1ccc2ccccc2n1)c1ccc2cc3C(=O)NCCCn3c2c1 InChI=1S/C22H18N4O2/c27-21(25-20-9-8-14-4-1-2-5-17(14)24-20)16-7-6-15-12-19-22(28)23-10-3-11-26(19)18(15)13-16/h1-2,4-9,12-13H,3,10-11H2,(H,23,28)(H,24,25,27) WBSLEWFFUMKPFM-UHFFFAOYSA-N 50361849 CHEMBL1938800::US9150577, 5 Ribosomal protein S6 kinase alpha-3 Homo sapiens 68 ChEMBL 10.1016/j.bmcl.2011.10.030 10.7270/Q2XW4K7N 22100312 Boyer, SJ; Burke, J; Guo, X; Kirrane, TM; Snow, RJ; Zhang, Y; Sarko, C; Soleymanzadeh, L; Swinamer, A; Westbrook, J; Dicapua, F; Padyana, A; Cogan, D; Gao, A; Xiong, Z; Madwed, JB; Kashem, M; Kugler, S; O'Neill, MM Boehringer Ingelheim Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50361849 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50361849&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 57392456 136965911 CHEMBL1938800 ZINC73240558 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50712485 O=C(Nc1nc2ccccc2s1)c1ccc2cc3C(=O)NCCCn3c2c1 InChI=1S/C20H16N4O2S/c25-18(23-20-22-14-4-1-2-5-17(14)27-20)13-7-6-12-10-16-19(26)21-8-3-9-24(16)15(12)11-13/h1-2,4-7,10-11H,3,8-9H2,(H,21,26)(H,22,23,25) KWQKAUUPWOCABB-UHFFFAOYSA-N 50361872 CHEMBL1938801 Ribosomal protein S6 kinase alpha-3 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2011.10.030 10.7270/Q2XW4K7N 22100312 Boyer, SJ; Burke, J; Guo, X; Kirrane, TM; Snow, RJ; Zhang, Y; Sarko, C; Soleymanzadeh, L; Swinamer, A; Westbrook, J; Dicapua, F; Padyana, A; Cogan, D; Gao, A; Xiong, Z; Madwed, JB; Kashem, M; Kugler, S; O'Neill, MM Boehringer Ingelheim Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50361872 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50361872&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 57399400 136965934 CHEMBL1938801 ZINC73222481 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50712486 O=C(Nc1nc2ccccc2o1)c1ccc2cc3C(=O)NCCCn3c2c1 InChI=1S/C20H16N4O3/c25-18(23-20-22-14-4-1-2-5-17(14)27-20)13-7-6-12-10-16-19(26)21-8-3-9-24(16)15(12)11-13/h1-2,4-7,10-11H,3,8-9H2,(H,21,26)(H,22,23,25) XEMRFXZAJHTFCF-UHFFFAOYSA-N 50361850 CHEMBL1938802::US9150577, 112 Ribosomal protein S6 kinase alpha-3 Homo sapiens 367 ChEMBL 10.1016/j.bmcl.2011.10.030 10.7270/Q2XW4K7N 22100312 Boyer, SJ; Burke, J; Guo, X; Kirrane, TM; Snow, RJ; Zhang, Y; Sarko, C; Soleymanzadeh, L; Swinamer, A; Westbrook, J; Dicapua, F; Padyana, A; Cogan, D; Gao, A; Xiong, Z; Madwed, JB; Kashem, M; Kugler, S; O'Neill, MM Boehringer Ingelheim Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50361850 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50361850&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 57394163 136965912 CHEMBL1938802 ZINC73219797 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50712487 O=C(Nc1nc2ccccc2[nH]1)c1ccc2cc3C(=O)NCCCn3c2c1 InChI=1S/C20H17N5O2/c26-18(24-20-22-14-4-1-2-5-15(14)23-20)13-7-6-12-10-17-19(27)21-8-3-9-25(17)16(12)11-13/h1-2,4-7,10-11H,3,8-9H2,(H,21,27)(H2,22,23,24,26) TWQIEMARYWIEFU-UHFFFAOYSA-N 50361851 CHEMBL1938803::US9150577, 55 Ribosomal protein S6 kinase alpha-3 Homo sapiens 4 ChEMBL 10.1016/j.bmcl.2011.10.030 10.7270/Q2XW4K7N 22100312 Boyer, SJ; Burke, J; Guo, X; Kirrane, TM; Snow, RJ; Zhang, Y; Sarko, C; Soleymanzadeh, L; Swinamer, A; Westbrook, J; Dicapua, F; Padyana, A; Cogan, D; Gao, A; Xiong, Z; Madwed, JB; Kashem, M; Kugler, S; O'Neill, MM Boehringer Ingelheim Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50361851 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50361851&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 56834879 136965913 CHEMBL1938803 ZINC73240370 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50712488 Cn1c(NC(=O)c2ccc3cc4C(=O)NCCCn4c3c2)nc2ccccc12 InChI=1S/C21H19N5O2/c1-25-16-6-3-2-5-15(16)23-21(25)24-19(27)14-8-7-13-11-18-20(28)22-9-4-10-26(18)17(13)12-14/h2-3,5-8,11-12H,4,9-10H2,1H3,(H,22,28)(H,23,24,27) WIICYVHPNFINMO-UHFFFAOYSA-N 50360292 CHEMBL1933279::US9150577, 64 Ribosomal protein S6 kinase alpha-3 Homo sapiens 9 ChEMBL 10.1016/j.bmcl.2011.10.030 10.7270/Q2XW4K7N 22100312 Boyer, SJ; Burke, J; Guo, X; Kirrane, TM; Snow, RJ; Zhang, Y; Sarko, C; Soleymanzadeh, L; Swinamer, A; Westbrook, J; Dicapua, F; Padyana, A; Cogan, D; Gao, A; Xiong, Z; Madwed, JB; Kashem, M; Kugler, S; O'Neill, MM Boehringer Ingelheim Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50360292 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50360292&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 56834880 136964354 CHEMBL1933279 ZINC73224365 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50712489 O=C(Nc1ccccc1)c1ccc2cc3C(=O)NCCCn3c2c1 InChI=1S/C19H17N3O2/c23-18(21-15-5-2-1-3-6-15)14-8-7-13-11-17-19(24)20-9-4-10-22(17)16(13)12-14/h1-3,5-8,11-12H,4,9-10H2,(H,20,24)(H,21,23) NMSKCMQPIFOSHU-UHFFFAOYSA-N 50361840 CHEMBL1938781::US9150577, 178 Ribosomal protein S6 kinase alpha-3 Homo sapiens 290 ChEMBL 10.1016/j.bmcl.2011.10.030 10.7270/Q2XW4K7N 22100312 Boyer, SJ; Burke, J; Guo, X; Kirrane, TM; Snow, RJ; Zhang, Y; Sarko, C; Soleymanzadeh, L; Swinamer, A; Westbrook, J; Dicapua, F; Padyana, A; Cogan, D; Gao, A; Xiong, Z; Madwed, JB; Kashem, M; Kugler, S; O'Neill, MM Boehringer Ingelheim Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50361840 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50361840&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 57392344 136965902 CHEMBL1938781 ZINC73160037 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50712490 Clc1ccc(NC(=O)c2ccc3cc4C(=O)NCCCn4c3c2)cc1 InChI=1S/C19H16ClN3O2/c20-14-4-6-15(7-5-14)22-18(24)13-3-2-12-10-17-19(25)21-8-1-9-23(17)16(12)11-13/h2-7,10-11H,1,8-9H2,(H,21,25)(H,22,24) GMVUXANRAYNFHC-UHFFFAOYSA-N 50361873 CHEMBL1938782::US9150577, 4 Ribosomal protein S6 kinase alpha-3 Homo sapiens 180 ChEMBL 10.1016/j.bmcl.2011.10.030 10.7270/Q2XW4K7N 22100312 Boyer, SJ; Burke, J; Guo, X; Kirrane, TM; Snow, RJ; Zhang, Y; Sarko, C; Soleymanzadeh, L; Swinamer, A; Westbrook, J; Dicapua, F; Padyana, A; Cogan, D; Gao, A; Xiong, Z; Madwed, JB; Kashem, M; Kugler, S; O'Neill, MM Boehringer Ingelheim Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50361873 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50361873&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 57390567 136965935 CHEMBL1938782 ZINC73160038 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50712491 Clc1cccc(NC(=O)c2ccc3cc4C(=O)NCCCn4c3c2)c1 InChI=1S/C19H16ClN3O2/c20-14-3-1-4-15(11-14)22-18(24)13-6-5-12-9-17-19(25)21-7-2-8-23(17)16(12)10-13/h1,3-6,9-11H,2,7-8H2,(H,21,25)(H,22,24) BTCGJYJHCYOBJS-UHFFFAOYSA-N 50361874 CHEMBL1938783::US9150577, 1 Ribosomal protein S6 kinase alpha-3 Homo sapiens 270 ChEMBL 10.1016/j.bmcl.2011.10.030 10.7270/Q2XW4K7N 22100312 Boyer, SJ; Burke, J; Guo, X; Kirrane, TM; Snow, RJ; Zhang, Y; Sarko, C; Soleymanzadeh, L; Swinamer, A; Westbrook, J; Dicapua, F; Padyana, A; Cogan, D; Gao, A; Xiong, Z; Madwed, JB; Kashem, M; Kugler, S; O'Neill, MM Boehringer Ingelheim Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50361874 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50361874&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 57401079 136965936 CHEMBL1938783 ZINC73164312 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50712492 NC(=O)c1ccc2cc3C(=O)NCCCn3c2c1 InChI=1S/C13H13N3O2/c14-12(17)9-3-2-8-6-11-13(18)15-4-1-5-16(11)10(8)7-9/h2-3,6-7H,1,4-5H2,(H2,14,17)(H,15,18) UUKWKSJYJTXOOA-UHFFFAOYSA-N 50361875 CHEMBL1938779 Ribosomal protein S6 kinase alpha-3 Homo sapiens 9100 ChEMBL 10.1016/j.bmcl.2011.10.030 10.7270/Q2XW4K7N 22100312 Boyer, SJ; Burke, J; Guo, X; Kirrane, TM; Snow, RJ; Zhang, Y; Sarko, C; Soleymanzadeh, L; Swinamer, A; Westbrook, J; Dicapua, F; Padyana, A; Cogan, D; Gao, A; Xiong, Z; Madwed, JB; Kashem, M; Kugler, S; O'Neill, MM Boehringer Ingelheim Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50361875 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50361875&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 57394084 136965937 CHEMBL1938779 ZINC73219172 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50696439 COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1OCCCN1CCOCC1 InChI=1S/C22H24ClFN4O3/c1-29-20-13-19-16(12-21(20)31-8-2-5-28-6-9-30-10-7-28)22(26-14-25-19)27-15-3-4-18(24)17(23)11-15/h3-4,11-14H,2,5-10H2,1H3,(H,25,26,27) XGALLCVXEZPNRQ-UHFFFAOYSA-N 5447 CHEMBL939::GEFITINIB::Iressa::N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-[3-(4-morpholinyl)propoxy]-4-quinazolinamine::N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[3-(morpholin-4-yl)propoxy]quinazolin-4-amine::US10106508, Gefitinib::US10507209, Compound Gefitinib::US9416123, Gefitinib::US9730934, Gefitinib::US9783524, Gefitinib::WO2022090481, Example gefitinib::ZD1839::cid_123631 Ribosomal protein S6 kinase alpha-3 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=5447 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=5447&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 2ITO,2ITY,2ITZ 123631 8035066 49668 CHEMBL939 DB00317 4941 ZINC19632614 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50697869 NC(=N)N\N=C/c1c(nc2sc(Br)cn12)-c1ccc(cc1)[N+]([O-])=O InChI=1S/C13H10BrN7O2S/c14-10-6-20-9(5-17-19-12(15)16)11(18-13(20)24-10)7-1-3-8(4-2-7)21(22)23/h1-6H,(H4,15,16,19)/b17-5- MICFEMGUNJSEGM-ZWSORDCHSA-N 50355550 CHEMBL1910608 Ribosomal protein S6 kinase alpha-3 Homo sapiens 607 ChEMBL 10.1016/j.ejmech.2011.07.001 10.7270/Q2NG4R1D 21794960 Andreani, A; Granaiola, M; Leoni, A; Locatelli, A; Morigi, R; Rambaldi, M; Varoli, L; Lannigan, D; Smith, J; Scudiero, D; Kondapaka, S; Shoemaker, RH Universit£ di Bologna http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50355550 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50355550&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 57393795 136959574 CHEMBL1910608 ZINC73138040 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50697875 CCN(CC)CCNC(=O)c1c(C)[nH]c(\C=C2/C(=O)Nc3ccc(F)cc23)c1C InChI=1S/C22H27FN4O2/c1-5-27(6-2)10-9-24-22(29)20-13(3)19(25-14(20)4)12-17-16-11-15(23)7-8-18(16)26-21(17)28/h7-8,11-12,25H,5-6,9-10H2,1-4H3,(H,24,29)(H,26,28)/b17-12- WINHZLLDWRZWRT-ATVHPVEESA-N 4814 CHEMBL535::N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide::N-[2-(diethylamino)ethyl]-5-{[(3Z)-5-fluoro-2-oxo-2,3-dihydro-1H-indol-3-ylidene]methyl}-2,4-dimethyl-1H-pyrrole-3-carboxamide::SU11248::SUNITINIB::SUNITINIB MALATE::US10464902, Sunitinib::US9163010, Sunitinib::US9914707, SU11248 Ribosomal protein S6 kinase alpha-3 Homo sapiens 184 ChEMBL 10.1016/j.ejmech.2011.07.001 10.7270/Q2NG4R1D 21794960 Andreani, A; Granaiola, M; Leoni, A; Locatelli, A; Morigi, R; Rambaldi, M; Varoli, L; Lannigan, D; Smith, J; Scudiero, D; Kondapaka, S; Shoemaker, RH Universit£ di Bologna http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=4814 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=4814&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search B49 6NG0,4KS8,3G0F,3G0E,2Y7J,6JOK,6M11,3MIY,3TI1,4QMZ,6V0X,6NFZ,6NFY,4AGD 5329102 8034462 38940 CHEMBL535 DB01268 5713 ZINC03964325 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50697882 Cc1nc(Nc2ncc(s2)C(=O)Nc2c(C)cccc2Cl)cc(n1)N1CCN(CCO)CC1 InChI=1S/C22H26ClN7O2S/c1-14-4-3-5-16(23)20(14)28-21(32)17-13-24-22(33-17)27-18-12-19(26-15(2)25-18)30-8-6-29(7-9-30)10-11-31/h3-5,12-13,31H,6-11H2,1-2H3,(H,28,32)(H,24,25,26,27) ZBNZXTGUTAYRHI-UHFFFAOYSA-N 13216 BMS-354825::CHEMBL1421::DASATINIB::N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl)]-2-methyl-4-pyrimidinyl]amino)]-1,3-thiazole-5-carboxamide::N-(2-chloro-6-methylphenyl)-2-({6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl}amino)-1,3-thiazole-5-carboxamide::US10294227, Code Dasatinib::cid_3062316::med.21724, Compound Dasatinib Ribosomal protein S6 kinase alpha-3 Homo sapiens >20000 ChEMBL 10.1016/j.ejmech.2011.07.001 10.7270/Q2NG4R1D 21794960 Andreani, A; Granaiola, M; Leoni, A; Locatelli, A; Morigi, R; Rambaldi, M; Varoli, L; Lannigan, D; Smith, J; Scudiero, D; Kondapaka, S; Shoemaker, RH Universit£ di Bologna http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13216 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13216&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 1N1 5BVW,5OWR,6FNM,6BSD,5I9Y,2ZVA,3OCT,7ERK,3QLG,3SXR,7N9G,4XLI,3OHT,2Y6O,3LFA,4XEY,2GQG,3K54,3G5D,4QMS,5VCV,5H2U 3062316 46513626 49375 CHEMBL1421 DB01254 5678 ZINC21982951 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50697890 NC(=N)N\N=C\c1c(nc2sc(Cl)cn12)-c1cc(Cl)sc1Cl InChI=1S/C11H7Cl3N6S2/c12-6-1-4(9(14)21-6)8-5(2-17-19-10(15)16)20-3-7(13)22-11(20)18-8/h1-3H,(H4,15,16,19)/b17-2+ BUGVQGBYHQSESO-LAZPYJJCSA-N 50355551 CHEMBL1910371 Ribosomal protein S6 kinase alpha-3 Homo sapiens 8260 ChEMBL 10.1016/j.ejmech.2011.07.001 10.7270/Q2NG4R1D 21794960 Andreani, A; Granaiola, M; Leoni, A; Locatelli, A; Morigi, R; Rambaldi, M; Varoli, L; Lannigan, D; Smith, J; Scudiero, D; Kondapaka, S; Shoemaker, RH Universit£ di Bologna http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50355551 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50355551&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 54770687 136959575 CHEMBL1910371 ZINC73277749 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50697891 NC(=N)N\N=C\c1c(nc2sc(Cl)cn12)-c1ccc(cc1)C#N InChI=1S/C14H10ClN7S/c15-11-7-22-10(6-19-21-13(17)18)12(20-14(22)23-11)9-3-1-8(5-16)2-4-9/h1-4,6-7H,(H4,17,18,21)/b19-6+ GGMBDYXEOHNEMP-KPSZGOFPSA-N 50355552 CHEMBL1910375 Ribosomal protein S6 kinase alpha-3 Homo sapiens 8550 ChEMBL 10.1016/j.ejmech.2011.07.001 10.7270/Q2NG4R1D 21794960 Andreani, A; Granaiola, M; Leoni, A; Locatelli, A; Morigi, R; Rambaldi, M; Varoli, L; Lannigan, D; Smith, J; Scudiero, D; Kondapaka, S; Shoemaker, RH Universit£ di Bologna http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50355552 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50355552&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 54770915 136959576 CHEMBL1910375 ZINC73140741 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50697892 NC(=N)N\N=C/c1c(nc2sc(F)cn12)-c1ccc(cc1)[N+]([O-])=O InChI=1S/C13H10FN7O2S/c14-10-6-20-9(5-17-19-12(15)16)11(18-13(20)24-10)7-1-3-8(4-2-7)21(22)23/h1-6H,(H4,15,16,19)/b17-5- CMMCZZCNNANQIV-ZWSORDCHSA-N 50355553 CHEMBL1910607 Ribosomal protein S6 kinase alpha-3 Homo sapiens 2150 ChEMBL 10.1016/j.ejmech.2011.07.001 10.7270/Q2NG4R1D 21794960 Andreani, A; Granaiola, M; Leoni, A; Locatelli, A; Morigi, R; Rambaldi, M; Varoli, L; Lannigan, D; Smith, J; Scudiero, D; Kondapaka, S; Shoemaker, RH Universit£ di Bologna http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50355553 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50355553&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 57397344 136959577 CHEMBL1910607 ZINC73140769 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50697894 NC(=N)N\N=C\c1c(nc2sc3ccccc3n12)-c1cc(Cl)sc1Cl InChI=1S/C15H10Cl2N6S2/c16-11-5-7(13(17)25-11)12-9(6-20-22-14(18)19)23-8-3-1-2-4-10(8)24-15(23)21-12/h1-6H,(H4,18,19,22)/b20-6+ YYPZEEYWQBKWHA-CGOBSMCZSA-N 50355554 CHEMBL1910616 Ribosomal protein S6 kinase alpha-3 Homo sapiens 12000 ChEMBL 10.1016/j.ejmech.2011.07.001 10.7270/Q2NG4R1D 21794960 Andreani, A; Granaiola, M; Leoni, A; Locatelli, A; Morigi, R; Rambaldi, M; Varoli, L; Lannigan, D; Smith, J; Scudiero, D; Kondapaka, S; Shoemaker, RH Universit£ di Bologna http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50355554 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50355554&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 54771590 136959578 CHEMBL1910616 ZINC73140774 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50697895 COc1cc(c(OC)cc1-c1nc2sc3ccccc3n2c1\C=N\[NH+]=C(\N)[NH-])[N+]([O-])=O InChI=1S/C19H16N7O4S/c1-29-14-8-12(26(27)28)15(30-2)7-10(14)17-13(9-22-24-18(20)21)25-11-5-3-4-6-16(11)31-19(25)23-17/h3-9H,1-2H3,(H3-,20,21,24)/q-1/p+1/b22-9+ HGDAOZHBPJQRAA-LSFURLLWSA-O 50355555 CHEMBL1910614 Ribosomal protein S6 kinase alpha-3 Homo sapiens 10150 ChEMBL 10.1016/j.ejmech.2011.07.001 10.7270/Q2NG4R1D 21794960 Andreani, A; Granaiola, M; Leoni, A; Locatelli, A; Morigi, R; Rambaldi, M; Varoli, L; Lannigan, D; Smith, J; Scudiero, D; Kondapaka, S; Shoemaker, RH Universit£ di Bologna http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50355555 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50355555&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 54771592 136959579 CHEMBL1910614 ZINC73138751 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50697896 COc1cc(c(OC)cc1-c1nc2ccccn2c1C=N[NH+]=C(N)[NH-])[N+]([O-])=O InChI=1S/C17H16N7O4/c1-27-13-8-11(24(25)26)14(28-2)7-10(13)16-12(9-20-22-17(18)19)23-6-4-3-5-15(23)21-16/h3-9H,1-2H3,(H3-,18,19,22)/q-1/p+1 FSHHYCRVVBWIDI-UHFFFAOYSA-O 50355556 CHEMBL1910623 Ribosomal protein S6 kinase alpha-3 Homo sapiens 7800 ChEMBL 10.1016/j.ejmech.2011.07.001 10.7270/Q2NG4R1D 21794960 Andreani, A; Granaiola, M; Leoni, A; Locatelli, A; Morigi, R; Rambaldi, M; Varoli, L; Lannigan, D; Smith, J; Scudiero, D; Kondapaka, S; Shoemaker, RH Universit£ di Bologna http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50355556 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50355556&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 54771822 136959580 CHEMBL1910623 ZINC73141060 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50697897 NC(=N)N\N=C\c1c(nc2sc(Cl)cn12)-c1ccc(cc1)[N+]([O-])=O InChI=1S/C13H10ClN7O2S/c14-10-6-20-9(5-17-19-12(15)16)11(18-13(20)24-10)7-1-3-8(4-2-7)21(22)23/h1-6H,(H4,15,16,19)/b17-5+ YCSSRNBNPPIVPE-YAXRCOADSA-N 50355557 CHEMBL1910625 Ribosomal protein S6 kinase alpha-3 Homo sapiens 970 ChEMBL 10.1016/j.ejmech.2011.07.001 10.7270/Q2NG4R1D 21794960 Andreani, A; Granaiola, M; Leoni, A; Locatelli, A; Morigi, R; Rambaldi, M; Varoli, L; Lannigan, D; Smith, J; Scudiero, D; Kondapaka, S; Shoemaker, RH Universit£ di Bologna http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50355557 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50355557&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 9572531 136959581 CHEMBL1910625 ZINC13005170 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50697898 Cc1cn2c(\C=N\NC(N)=N)c(nc2s1)-c1ccc(cc1)[N+]([O-])=O InChI=1S/C14H13N7O2S/c1-8-7-20-11(6-17-19-13(15)16)12(18-14(20)24-8)9-2-4-10(5-3-9)21(22)23/h2-7H,1H3,(H4,15,16,19)/b17-6+ KUDXUEHWTVQCCV-UBKPWBPPSA-N 50355558 CHEMBL1910626 Ribosomal protein S6 kinase alpha-3 Homo sapiens 2800 ChEMBL 10.1016/j.ejmech.2011.07.001 10.7270/Q2NG4R1D 21794960 Andreani, A; Granaiola, M; Leoni, A; Locatelli, A; Morigi, R; Rambaldi, M; Varoli, L; Lannigan, D; Smith, J; Scudiero, D; Kondapaka, S; Shoemaker, RH Universit£ di Bologna http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50355558 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50355558&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 9572535 136959582 CHEMBL1910626 ZINC13005172 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50697899 NC(N)=NN=Cc1c(nc2ccccn12)-c1ccc(Cl)c(c1)[N+]([O-])=O InChI=1S/C15H12ClN7O2/c16-10-5-4-9(7-11(10)23(24)25)14-12(8-19-21-15(17)18)22-6-2-1-3-13(22)20-14/h1-8H,(H4,17,18,21) ORDQOXBBVYVPCM-UHFFFAOYSA-N 50355559 CHEMBL1910627 Ribosomal protein S6 kinase alpha-3 Homo sapiens 2890 ChEMBL 10.1016/j.ejmech.2011.07.001 10.7270/Q2NG4R1D 21794960 Andreani, A; Granaiola, M; Leoni, A; Locatelli, A; Morigi, R; Rambaldi, M; Varoli, L; Lannigan, D; Smith, J; Scudiero, D; Kondapaka, S; Shoemaker, RH Universit£ di Bologna http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50355559 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50355559&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 24205074 136959583 CHEMBL1910627 ZINC29133078 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50697900 NC(=N)N\N=C\c1c(nc2sccn12)-c1ccc(N)cc1 InChI=1S/C13H13N7S/c14-9-3-1-8(2-4-9)11-10(7-17-19-12(15)16)20-5-6-21-13(20)18-11/h1-7H,14H2,(H4,15,16,19)/b17-7+ ZQVQBYSSJORMHW-REZTVBANSA-N 50355560 CHEMBL1910628 Ribosomal protein S6 kinase alpha-3 Homo sapiens 3000 ChEMBL 10.1016/j.ejmech.2011.07.001 10.7270/Q2NG4R1D 21794960 Andreani, A; Granaiola, M; Leoni, A; Locatelli, A; Morigi, R; Rambaldi, M; Varoli, L; Lannigan, D; Smith, J; Scudiero, D; Kondapaka, S; Shoemaker, RH Universit£ di Bologna http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50355560 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50355560&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 9572245 136959584 CHEMBL1910628 ZINC13219908 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50697901 NC(=N)N\N=C\c1c(nc2sccn12)-c1ccc(Cl)c(c1)[N+]([O-])=O InChI=1S/C13H10ClN7O2S/c14-8-2-1-7(5-9(8)21(22)23)11-10(6-17-19-12(15)16)20-3-4-24-13(20)18-11/h1-6H,(H4,15,16,19)/b17-6+ XOYZTUDMUAFNPF-UBKPWBPPSA-N 50355561 CHEMBL1910629 Ribosomal protein S6 kinase alpha-3 Homo sapiens 3130 ChEMBL 10.1016/j.ejmech.2011.07.001 10.7270/Q2NG4R1D 21794960 Andreani, A; Granaiola, M; Leoni, A; Locatelli, A; Morigi, R; Rambaldi, M; Varoli, L; Lannigan, D; Smith, J; Scudiero, D; Kondapaka, S; Shoemaker, RH Universit£ di Bologna http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50355561 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50355561&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 9572244 136959585 CHEMBL1910629 ZINC13219903 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50697902 COc1cc(c(OC)cc1-c1nc2sccn2c1\C=N\NC(N)=N)[N+]([O-])=O InChI=1S/C15H15N7O4S/c1-25-11-6-9(22(23)24)12(26-2)5-8(11)13-10(7-18-20-14(16)17)21-3-4-27-15(21)19-13/h3-7H,1-2H3,(H4,16,17,20)/b18-7+ DZYAMRZMUVLFTD-CNHKJKLMSA-N 50355562 CHEMBL1910630 Ribosomal protein S6 kinase alpha-3 Homo sapiens 3580 ChEMBL 10.1016/j.ejmech.2011.07.001 10.7270/Q2NG4R1D 21794960 Andreani, A; Granaiola, M; Leoni, A; Locatelli, A; Morigi, R; Rambaldi, M; Varoli, L; Lannigan, D; Smith, J; Scudiero, D; Kondapaka, S; Shoemaker, RH Universit£ di Bologna http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50355562 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50355562&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 9572736 136959586 CHEMBL1910630 ZINC28476212 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50697903 Cc1cn2c(\C=N\NC(N)=N)c(nc2s1)-c1ccc(Cl)c(c1)[N+]([O-])=O InChI=1S/C14H12ClN7O2S/c1-7-6-21-11(5-18-20-13(16)17)12(19-14(21)25-7)8-2-3-9(15)10(4-8)22(23)24/h2-6H,1H3,(H4,16,17,20)/b18-5+ UZGUZZAJIKMRJR-BLLMUTORSA-N 50355563 CHEMBL1910631 Ribosomal protein S6 kinase alpha-3 Homo sapiens 3760 ChEMBL 10.1016/j.ejmech.2011.07.001 10.7270/Q2NG4R1D 21794960 Andreani, A; Granaiola, M; Leoni, A; Locatelli, A; Morigi, R; Rambaldi, M; Varoli, L; Lannigan, D; Smith, J; Scudiero, D; Kondapaka, S; Shoemaker, RH Universit£ di Bologna http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50355563 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50355563&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 9572533 136959587 CHEMBL1910631 ZINC05892909 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50697904 Cc1cn2c(\C=N\NC(N)=N)c(nc2s1)-c1cc(c(Cl)cc1Cl)[N+]([O-])=O InChI=1S/C14H11Cl2N7O2S/c1-6-5-22-11(4-19-21-13(17)18)12(20-14(22)26-6)7-2-10(23(24)25)9(16)3-8(7)15/h2-5H,1H3,(H4,17,18,21)/b19-4+ QAQIMUUVPNQQJQ-RMOCHZDMSA-N 50355564 CHEMBL1910632 Ribosomal protein S6 kinase alpha-3 Homo sapiens 4530 ChEMBL 10.1016/j.ejmech.2011.07.001 10.7270/Q2NG4R1D 21794960 Andreani, A; Granaiola, M; Leoni, A; Locatelli, A; Morigi, R; Rambaldi, M; Varoli, L; Lannigan, D; Smith, J; Scudiero, D; Kondapaka, S; Shoemaker, RH Universit£ di Bologna http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50355564 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50355564&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 9572624 136959588 CHEMBL1910632 ZINC38807567 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50697905 NC(=N)N\N=C\c1c(nc2sccn12)-c1ccc(cc1)[N+]([O-])=O InChI=1S/C13H11N7O2S/c14-12(15)18-16-7-10-11(17-13-19(10)5-6-23-13)8-1-3-9(4-2-8)20(21)22/h1-7H,(H4,14,15,18)/b16-7+ NNZTXWZRQCPOLY-FRKPEAEDSA-N 50355565 CHEMBL1910633 Ribosomal protein S6 kinase alpha-3 Homo sapiens 5660 ChEMBL 10.1016/j.ejmech.2011.07.001 10.7270/Q2NG4R1D 21794960 Andreani, A; Granaiola, M; Leoni, A; Locatelli, A; Morigi, R; Rambaldi, M; Varoli, L; Lannigan, D; Smith, J; Scudiero, D; Kondapaka, S; Shoemaker, RH Universit£ di Bologna http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50355565 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50355565&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 9572240 136959589 CHEMBL1910633 ZINC13219899 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50697906 NC(=N)N\N=C\c1c(nc2sc(Cl)cn12)-c1ccc(Cl)c(c1)[N+]([O-])=O InChI=1S/C13H9Cl2N7O2S/c14-7-2-1-6(3-8(7)22(23)24)11-9(4-18-20-12(16)17)21-5-10(15)25-13(21)19-11/h1-5H,(H4,16,17,20)/b18-4+ ZWMMBIQIDRNHPQ-JJPRUIFNSA-N 50355566 CHEMBL1910634 Ribosomal protein S6 kinase alpha-3 Homo sapiens 5850 ChEMBL 10.1016/j.ejmech.2011.07.001 10.7270/Q2NG4R1D 21794960 Andreani, A; Granaiola, M; Leoni, A; Locatelli, A; Morigi, R; Rambaldi, M; Varoli, L; Lannigan, D; Smith, J; Scudiero, D; Kondapaka, S; Shoemaker, RH Universit£ di Bologna http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50355566 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50355566&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 9572620 136959590 CHEMBL1910634 ZINC05974001 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50697907 NC(=N)N\N=C\c1c(nc2sccn12)-c1cc(c(Cl)cc1Cl)[N+]([O-])=O InChI=1S/C13H9Cl2N7O2S/c14-7-4-8(15)9(22(23)24)3-6(7)11-10(5-18-20-12(16)17)21-1-2-25-13(21)19-11/h1-5H,(H4,16,17,20)/b18-5+ FEUFPNJBZIRVDI-BLLMUTORSA-N 50355567 CHEMBL1910635 Ribosomal protein S6 kinase alpha-3 Homo sapiens 5930 ChEMBL 10.1016/j.ejmech.2011.07.001 10.7270/Q2NG4R1D 21794960 Andreani, A; Granaiola, M; Leoni, A; Locatelli, A; Morigi, R; Rambaldi, M; Varoli, L; Lannigan, D; Smith, J; Scudiero, D; Kondapaka, S; Shoemaker, RH Universit£ di Bologna http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50355567 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50355567&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 9572545 136959591 CHEMBL1910635 ZINC13005177 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50697908 CCCc1cn2c(\C=N\NC(N)=N)c(nc2s1)-c1cc(c(Cl)cc1Cl)[N+]([O-])=O InChI=1S/C16H15Cl2N7O2S/c1-2-3-8-7-24-13(6-21-23-15(19)20)14(22-16(24)28-8)9-4-12(25(26)27)11(18)5-10(9)17/h4-7H,2-3H2,1H3,(H4,19,20,23)/b21-6+ GOSWCDQMNPBTEQ-AERZKKPOSA-N 50355568 CHEMBL1910636 Ribosomal protein S6 kinase alpha-3 Homo sapiens 5970 ChEMBL 10.1016/j.ejmech.2011.07.001 10.7270/Q2NG4R1D 21794960 Andreani, A; Granaiola, M; Leoni, A; Locatelli, A; Morigi, R; Rambaldi, M; Varoli, L; Lannigan, D; Smith, J; Scudiero, D; Kondapaka, S; Shoemaker, RH Universit£ di Bologna http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50355568 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50355568&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 9572659 136959592 CHEMBL1910636 ZINC38807585 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50697909 NC(=N)N\N=C\c1c(nc2sc(Cl)cn12)-c1cccc(c1)[N+]([O-])=O InChI=1S/C13H10ClN7O2S/c14-10-6-20-9(5-17-19-12(15)16)11(18-13(20)24-10)7-2-1-3-8(4-7)21(22)23/h1-6H,(H4,15,16,19)/b17-5+ ZUCVGJVUJSOEMH-YAXRCOADSA-N 50355569 CHEMBL1910637 Ribosomal protein S6 kinase alpha-3 Homo sapiens 6030 ChEMBL 10.1016/j.ejmech.2011.07.001 10.7270/Q2NG4R1D 21794960 Andreani, A; Granaiola, M; Leoni, A; Locatelli, A; Morigi, R; Rambaldi, M; Varoli, L; Lannigan, D; Smith, J; Scudiero, D; Kondapaka, S; Shoemaker, RH Universit£ di Bologna http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50355569 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50355569&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 57393798 136959593 CHEMBL1910637 ZINC05974055 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50697910 CCCc1cn2c(\C=N\NC(N)=N)c(nc2s1)-c1ccc(Cl)c(c1)[N+]([O-])=O InChI=1S/C16H16ClN7O2S/c1-2-3-10-8-23-13(7-20-22-15(18)19)14(21-16(23)27-10)9-4-5-11(17)12(6-9)24(25)26/h4-8H,2-3H2,1H3,(H4,18,19,22)/b20-7+ MEQJPRCKDCZJPZ-IFRROFPPSA-N 50355570 CHEMBL1910744 Ribosomal protein S6 kinase alpha-3 Homo sapiens 6430 ChEMBL 10.1016/j.ejmech.2011.07.001 10.7270/Q2NG4R1D 21794960 Andreani, A; Granaiola, M; Leoni, A; Locatelli, A; Morigi, R; Rambaldi, M; Varoli, L; Lannigan, D; Smith, J; Scudiero, D; Kondapaka, S; Shoemaker, RH Universit£ di Bologna http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50355570 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50355570&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 9572657 136959594 CHEMBL1910744 ZINC05883414 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50697911 NC(=N)N\N=C\c1c(nc2sc3ccccc3n12)-c1ccc(Cl)c(c1)[N+]([O-])=O InChI=1S/C17H12ClN7O2S/c18-10-6-5-9(7-12(10)25(26)27)15-13(8-21-23-16(19)20)24-11-3-1-2-4-14(11)28-17(24)22-15/h1-8H,(H4,19,20,23)/b21-8+ DHYJCJJQVBIBBN-ODCIPOBUSA-N 50355571 CHEMBL1910745 Ribosomal protein S6 kinase alpha-3 Homo sapiens 7320 ChEMBL 10.1016/j.ejmech.2011.07.001 10.7270/Q2NG4R1D 21794960 Andreani, A; Granaiola, M; Leoni, A; Locatelli, A; Morigi, R; Rambaldi, M; Varoli, L; Lannigan, D; Smith, J; Scudiero, D; Kondapaka, S; Shoemaker, RH Universit£ di Bologna http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50355571 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50355571&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 24204558 136959595 CHEMBL1910745 ZINC29133077 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50697912 COc1cc(c(OC)cc1-c1nc2sc(Cl)cn2c1\C=N\NC(=N)N\N=C\c1c(nc2sc(Cl)cn12)-c1cc(OC)c(cc1OC)[N+]([O-])=O)[N+]([O-])=O InChI=1S/C29H23Cl2N11O8S2/c1-47-19-7-15(41(43)44)21(49-3)5-13(19)25-17(39-11-23(30)51-28(39)35-25)9-33-37-27(32)38-34-10-18-26(36-29-40(18)12-24(31)52-29)14-6-22(50-4)16(42(45)46)8-20(14)48-2/h5-12H,1-4H3,(H3,32,37,38)/b33-9+,34-10+ RFDSTFAKPLBCAT-HDMIYARESA-N 50355572 CHEMBL1910746 Ribosomal protein S6 kinase alpha-3 Homo sapiens 11400 ChEMBL 10.1016/j.ejmech.2011.07.001 10.7270/Q2NG4R1D 21794960 Andreani, A; Granaiola, M; Leoni, A; Locatelli, A; Morigi, R; Rambaldi, M; Varoli, L; Lannigan, D; Smith, J; Scudiero, D; Kondapaka, S; Shoemaker, RH Universit£ di Bologna http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50355572 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50355572&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 57397354 136959596 CHEMBL1910746 ZINC95549041 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50697913 CCCc1cn2c(\C=N\NC(N)=N)c(nc2s1)-c1cccc(c1)[N+]([O-])=O InChI=1S/C16H17N7O2S/c1-2-4-12-9-22-13(8-19-21-15(17)18)14(20-16(22)26-12)10-5-3-6-11(7-10)23(24)25/h3,5-9H,2,4H2,1H3,(H4,17,18,21)/b19-8+ BWAWHQNALMDQRJ-UFWORHAWSA-N 50355573 CHEMBL1910747 Ribosomal protein S6 kinase alpha-3 Homo sapiens 13250 ChEMBL 10.1016/j.ejmech.2011.07.001 10.7270/Q2NG4R1D 21794960 Andreani, A; Granaiola, M; Leoni, A; Locatelli, A; Morigi, R; Rambaldi, M; Varoli, L; Lannigan, D; Smith, J; Scudiero, D; Kondapaka, S; Shoemaker, RH Universit£ di Bologna http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50355573 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50355573&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 9572661 136959597 CHEMBL1910747 ZINC05883420 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50697914 Cc1sc2nc(c(\C=N\NC(N)=N)n2c1C)-c1ccc(Cl)c(c1)[N+]([O-])=O InChI=1S/C15H14ClN7O2S/c1-7-8(2)26-15-20-13(12(22(7)15)6-19-21-14(17)18)9-3-4-10(16)11(5-9)23(24)25/h3-6H,1-2H3,(H4,17,18,21)/b19-6+ CWVQXDDCNNKJMV-KPSZGOFPSA-N 50355574 CHEMBL1910748 Ribosomal protein S6 kinase alpha-3 Homo sapiens 13930 ChEMBL 10.1016/j.ejmech.2011.07.001 10.7270/Q2NG4R1D 21794960 Andreani, A; Granaiola, M; Leoni, A; Locatelli, A; Morigi, R; Rambaldi, M; Varoli, L; Lannigan, D; Smith, J; Scudiero, D; Kondapaka, S; Shoemaker, RH Universit£ di Bologna http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50355574 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50355574&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 9572547 136959598 CHEMBL1910748 ZINC05891586 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50697915 NC(=N)N\N=C\c1c(nc2sc(Cl)cn12)-c1ccc(Cl)cc1 InChI=1S/C13H10Cl2N6S/c14-8-3-1-7(2-4-8)11-9(5-18-20-12(16)17)21-6-10(15)22-13(21)19-11/h1-6H,(H4,16,17,20)/b18-5+ APAGHGRQPZBKBY-BLLMUTORSA-N 50355575 CHEMBL1910749 Ribosomal protein S6 kinase alpha-3 Homo sapiens 14000 ChEMBL 10.1016/j.ejmech.2011.07.001 10.7270/Q2NG4R1D 21794960 Andreani, A; Granaiola, M; Leoni, A; Locatelli, A; Morigi, R; Rambaldi, M; Varoli, L; Lannigan, D; Smith, J; Scudiero, D; Kondapaka, S; Shoemaker, RH Universit£ di Bologna http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50355575 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50355575&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 9572071 136959599 CHEMBL1910749 ZINC13219199 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50697916 Cc1cn2c(\C=N\NC(N)=N)c(nc2s1)-c1cccc(c1)[N+]([O-])=O InChI=1S/C14H13N7O2S/c1-8-7-20-11(6-17-19-13(15)16)12(18-14(20)24-8)9-3-2-4-10(5-9)21(22)23/h2-7H,1H3,(H4,15,16,19)/b17-6+ JOCTUJYQWRSKIG-UBKPWBPPSA-N 50355576 CHEMBL1910750 Ribosomal protein S6 kinase alpha-3 Homo sapiens 17500 ChEMBL 10.1016/j.ejmech.2011.07.001 10.7270/Q2NG4R1D 21794960 Andreani, A; Granaiola, M; Leoni, A; Locatelli, A; Morigi, R; Rambaldi, M; Varoli, L; Lannigan, D; Smith, J; Scudiero, D; Kondapaka, S; Shoemaker, RH Universit£ di Bologna http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50355576 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50355576&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 9572626 136959600 CHEMBL1910750 ZINC05892915 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50697923 Cc1cn2c(\C=N/NC(N)=N)c(nc2s1)-c1ccc(F)cc1 InChI=1S/C14H13FN6S/c1-8-7-21-11(6-18-20-13(16)17)12(19-14(21)22-8)9-2-4-10(15)5-3-9/h2-7H,1H3,(H4,16,17,20)/b18-6- BMIJOLMGBAUKDY-FXBPXSCXSA-N 50355577 CHEMBL1910605 Ribosomal protein S6 kinase alpha-3 Homo sapiens >100000 ChEMBL 10.1016/j.ejmech.2011.07.001 10.7270/Q2NG4R1D 21794960 Andreani, A; Granaiola, M; Leoni, A; Locatelli, A; Morigi, R; Rambaldi, M; Varoli, L; Lannigan, D; Smith, J; Scudiero, D; Kondapaka, S; Shoemaker, RH Universit£ di Bologna http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50355577 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50355577&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 57390271 136959601 CHEMBL1910605 ZINC73140765 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50697924 Cc1cn2c(\C=N/NC(N)=N)c(nc2s1)-c1ccc(F)c(c1)[N+]([O-])=O InChI=1S/C14H12FN7O2S/c1-7-6-21-11(5-18-20-13(16)17)12(19-14(21)25-7)8-2-3-9(15)10(4-8)22(23)24/h2-6H,1H3,(H4,16,17,20)/b18-5- HWYSHOTVYYFXKC-DVZOWYKESA-N 50355578 CHEMBL1910606 Ribosomal protein S6 kinase alpha-3 Homo sapiens 30670 ChEMBL 10.1016/j.ejmech.2011.07.001 10.7270/Q2NG4R1D 21794960 Andreani, A; Granaiola, M; Leoni, A; Locatelli, A; Morigi, R; Rambaldi, M; Varoli, L; Lannigan, D; Smith, J; Scudiero, D; Kondapaka, S; Shoemaker, RH Universit£ di Bologna http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50355578 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50355578&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 57390273 136959602 CHEMBL1910606 ZINC73140766 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50697925 Clc1cc(c(Cl)s1)-c1nc2sc(Cl)cn2c1\C=N\NC1=NCCN1 InChI=1S/C13H9Cl3N6S2/c14-8-3-6(11(16)23-8)10-7(4-19-21-12-17-1-2-18-12)22-5-9(15)24-13(22)20-10/h3-5H,1-2H2,(H2,17,18,21)/b19-4+ VRHQICAGVHXFCJ-RMOCHZDMSA-N 50355579 CHEMBL1910609 Ribosomal protein S6 kinase alpha-3 Homo sapiens >100000 ChEMBL 10.1016/j.ejmech.2011.07.001 10.7270/Q2NG4R1D 21794960 Andreani, A; Granaiola, M; Leoni, A; Locatelli, A; Morigi, R; Rambaldi, M; Varoli, L; Lannigan, D; Smith, J; Scudiero, D; Kondapaka, S; Shoemaker, RH Universit£ di Bologna http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50355579 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50355579&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 24901001 136959603 CHEMBL1910609 ZINC73139297 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50697926 Cc1nn2c(\C=N\NC3=NCCN3)c(nc2s1)-c1ccc(Cl)c(c1)[N+]([O-])=O InChI=1S/C15H13ClN8O2S/c1-8-22-23-12(7-19-21-14-17-4-5-18-14)13(20-15(23)27-8)9-2-3-10(16)11(6-9)24(25)26/h2-3,6-7H,4-5H2,1H3,(H2,17,18,21)/b19-7+ KKPKGSDJNKXNFL-FBCYGCLPSA-N 50355580 CHEMBL1910610 Ribosomal protein S6 kinase alpha-3 Homo sapiens >100000 ChEMBL 10.1016/j.ejmech.2011.07.001 10.7270/Q2NG4R1D 21794960 Andreani, A; Granaiola, M; Leoni, A; Locatelli, A; Morigi, R; Rambaldi, M; Varoli, L; Lannigan, D; Smith, J; Scudiero, D; Kondapaka, S; Shoemaker, RH Universit£ di Bologna http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50355580 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50355580&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 54771375 136959604 CHEMBL1910610 ZINC73139747 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50697927 Clc1cc(c(Cl)s1)-c1nc2sc3ccccc3n2c1\C=N\NC1=NCCN1 InChI=1S/C17H12Cl2N6S2/c18-13-7-9(15(19)27-13)14-11(8-22-24-16-20-5-6-21-16)25-10-3-1-2-4-12(10)26-17(25)23-14/h1-4,7-8H,5-6H2,(H2,20,21,24)/b22-8+ NQVODTWQQHAQOK-GZIVZEMBSA-N 50355581 CHEMBL1910617 Ribosomal protein S6 kinase alpha-3 Homo sapiens >100000 ChEMBL 10.1016/j.ejmech.2011.07.001 10.7270/Q2NG4R1D 21794960 Andreani, A; Granaiola, M; Leoni, A; Locatelli, A; Morigi, R; Rambaldi, M; Varoli, L; Lannigan, D; Smith, J; Scudiero, D; Kondapaka, S; Shoemaker, RH Universit£ di Bologna http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50355581 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50355581&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 54771594 136959605 CHEMBL1910617 ZINC73140095 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50697928 NC(N)=NN=Cc1c(nc2ccccn12)-c1cc(Cl)sc1Cl InChI=1S/C13H10Cl2N6S/c14-9-5-7(12(15)22-9)11-8(6-18-20-13(16)17)21-4-2-1-3-10(21)19-11/h1-6H,(H4,16,17,20) XQVFQPCQBMMTAX-UHFFFAOYSA-N 50355582 CHEMBL1910622 Ribosomal protein S6 kinase alpha-3 Homo sapiens >100000 ChEMBL 10.1016/j.ejmech.2011.07.001 10.7270/Q2NG4R1D 21794960 Andreani, A; Granaiola, M; Leoni, A; Locatelli, A; Morigi, R; Rambaldi, M; Varoli, L; Lannigan, D; Smith, J; Scudiero, D; Kondapaka, S; Shoemaker, RH Universit£ di Bologna http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50355582 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50355582&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 54771820 136959606 CHEMBL1910622 ZINC73293883 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50697977 NC(=N)N\N=C\c1c(nc2sc(Cl)cn12)-c1ccc(F)c(c1)[N+]([O-])=O InChI=1S/C13H9ClFN7O2S/c14-10-5-21-9(4-18-20-12(16)17)11(19-13(21)25-10)6-1-2-7(15)8(3-6)22(23)24/h1-5H,(H4,16,17,20)/b18-4+ BLMHMCBOYMBHEJ-JJPRUIFNSA-N 50355583 CHEMBL1910374 Ribosomal protein S6 kinase alpha-3 Homo sapiens 3930 ChEMBL 10.1016/j.ejmech.2011.07.001 10.7270/Q2NG4R1D 21794960 Andreani, A; Granaiola, M; Leoni, A; Locatelli, A; Morigi, R; Rambaldi, M; Varoli, L; Lannigan, D; Smith, J; Scudiero, D; Kondapaka, S; Shoemaker, RH Universit£ di Bologna http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50355583 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50355583&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 54770693 136959607 CHEMBL1910374 ZINC73140739 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50697980 NC(=N)N\N=C\c1c(nc2sc(Cl)cn12)-c1ccccc1 InChI=1S/C13H11ClN6S/c14-10-7-20-9(6-17-19-12(15)16)11(18-13(20)21-10)8-4-2-1-3-5-8/h1-7H,(H4,15,16,19)/b17-6+ RKVBISYCPBJKBQ-UBKPWBPPSA-N 50355584 CHEMBL1910372 Ribosomal protein S6 kinase alpha-3 Homo sapiens >100000 ChEMBL 10.1016/j.ejmech.2011.07.001 10.7270/Q2NG4R1D 21794960 Andreani, A; Granaiola, M; Leoni, A; Locatelli, A; Morigi, R; Rambaldi, M; Varoli, L; Lannigan, D; Smith, J; Scudiero, D; Kondapaka, S; Shoemaker, RH Universit£ di Bologna http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50355584 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50355584&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 54770689 136959608 CHEMBL1910372 ZINC73140733 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50697981 NC(=N)N\N=C\c1c(nc2sc(Cl)cn12)-c1ccc(F)cc1 InChI=1S/C13H10ClFN6S/c14-10-6-21-9(5-18-20-12(16)17)11(19-13(21)22-10)7-1-3-8(15)4-2-7/h1-6H,(H4,16,17,20)/b18-5+ SRPXUHSRAGHEKA-BLLMUTORSA-N 50355585 CHEMBL1910373 Ribosomal protein S6 kinase alpha-3 Homo sapiens 86000 ChEMBL 10.1016/j.ejmech.2011.07.001 10.7270/Q2NG4R1D 21794960 Andreani, A; Granaiola, M; Leoni, A; Locatelli, A; Morigi, R; Rambaldi, M; Varoli, L; Lannigan, D; Smith, J; Scudiero, D; Kondapaka, S; Shoemaker, RH Universit£ di Bologna http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50355585 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50355585&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 54770691 136959609 CHEMBL1910373 ZINC73140737 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50697982 Cc1nn2c(\C=N\NC(N)=N)c(nc2s1)-c1cc(Cl)sc1Cl InChI=1S/C11H9Cl2N7S2/c1-4-19-20-6(3-16-18-10(14)15)8(17-11(20)21-4)5-2-7(12)22-9(5)13/h2-3H,1H3,(H4,14,15,18)/b16-3+ CHJVYGVSYSSJQB-HQYXKAPLSA-N 50355586 CHEMBL1910376 Ribosomal protein S6 kinase alpha-3 Homo sapiens >100000 ChEMBL 10.1016/j.ejmech.2011.07.001 10.7270/Q2NG4R1D 21794960 Andreani, A; Granaiola, M; Leoni, A; Locatelli, A; Morigi, R; Rambaldi, M; Varoli, L; Lannigan, D; Smith, J; Scudiero, D; Kondapaka, S; Shoemaker, RH Universit£ di Bologna http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50355586 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50355586&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 54770917 136959610 CHEMBL1910376 ZINC73140743 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50697983 COc1cc(c(OC)cc1-c1nc2sc(C)nn2c1\C=N/NC(N)=N)[N+]([O-])=O InChI=1S/C15H16N8O4S/c1-7-21-22-10(6-18-20-14(16)17)13(19-15(22)28-7)8-4-12(27-3)9(23(24)25)5-11(8)26-2/h4-6H,1-3H3,(H4,16,17,20)/b18-6- DXRNLURMSWHDFV-FXBPXSCXSA-N 50355587 CHEMBL1910595 Ribosomal protein S6 kinase alpha-3 Homo sapiens >100000 ChEMBL 10.1016/j.ejmech.2011.07.001 10.7270/Q2NG4R1D 21794960 Andreani, A; Granaiola, M; Leoni, A; Locatelli, A; Morigi, R; Rambaldi, M; Varoli, L; Lannigan, D; Smith, J; Scudiero, D; Kondapaka, S; Shoemaker, RH Universit£ di Bologna http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50355587 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50355587&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 57400761 136959611 CHEMBL1910595 ZINC73129288 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50697984 NC(=N)N\N=C/c1c(nc2sccn12)-c1ccc(F)cc1 InChI=1S/C13H11FN6S/c14-9-3-1-8(2-4-9)11-10(7-17-19-12(15)16)20-5-6-21-13(20)18-11/h1-7H,(H4,15,16,19)/b17-7- MUWRSCFJMALKJK-IDUWFGFVSA-N 50355588 CHEMBL1910597 Ribosomal protein S6 kinase alpha-3 Homo sapiens >100000 ChEMBL 10.1016/j.ejmech.2011.07.001 10.7270/Q2NG4R1D 21794960 Andreani, A; Granaiola, M; Leoni, A; Locatelli, A; Morigi, R; Rambaldi, M; Varoli, L; Lannigan, D; Smith, J; Scudiero, D; Kondapaka, S; Shoemaker, RH Universit£ di Bologna http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50355588 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50355588&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 57395512 136959612 CHEMBL1910597 ZINC73278655 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50697985 NC(=N)N\N=C/c1c(nc2sccn12)-c1ccccc1F InChI=1S/C13H11FN6S/c14-9-4-2-1-3-8(9)11-10(7-17-19-12(15)16)20-5-6-21-13(20)18-11/h1-7H,(H4,15,16,19)/b17-7- RABMNKPKFQQDQF-IDUWFGFVSA-N 50355589 CHEMBL1910598 Ribosomal protein S6 kinase alpha-3 Homo sapiens >100000 ChEMBL 10.1016/j.ejmech.2011.07.001 10.7270/Q2NG4R1D 21794960 Andreani, A; Granaiola, M; Leoni, A; Locatelli, A; Morigi, R; Rambaldi, M; Varoli, L; Lannigan, D; Smith, J; Scudiero, D; Kondapaka, S; Shoemaker, RH Universit£ di Bologna http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50355589 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50355589&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 57400763 136959613 CHEMBL1910598 ZINC73139134 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50697986 NC(=N)N\N=C/c1c(nc2sccn12)-c1c(F)cccc1F InChI=1S/C13H10F2N6S/c14-7-2-1-3-8(15)10(7)11-9(6-18-20-12(16)17)21-4-5-22-13(21)19-11/h1-6H,(H4,16,17,20)/b18-6- AHFUVESDONGJOE-FXBPXSCXSA-N 50355590 CHEMBL1910599 Ribosomal protein S6 kinase alpha-3 Homo sapiens >100000 ChEMBL 10.1016/j.ejmech.2011.07.001 10.7270/Q2NG4R1D 21794960 Andreani, A; Granaiola, M; Leoni, A; Locatelli, A; Morigi, R; Rambaldi, M; Varoli, L; Lannigan, D; Smith, J; Scudiero, D; Kondapaka, S; Shoemaker, RH Universit£ di Bologna http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50355590 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50355590&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 57395514 136959614 CHEMBL1910599 ZINC73139135 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50697987 NC(=N)N\N=C/c1c(nc2sccn12)-c1ccc(F)c(F)c1 InChI=1S/C13H10F2N6S/c14-8-2-1-7(5-9(8)15)11-10(6-18-20-12(16)17)21-3-4-22-13(21)19-11/h1-6H,(H4,16,17,20)/b18-6- ISPVHAKARZIEBW-FXBPXSCXSA-N 50355591 CHEMBL1910600 Ribosomal protein S6 kinase alpha-3 Homo sapiens >100000 ChEMBL 10.1016/j.ejmech.2011.07.001 10.7270/Q2NG4R1D 21794960 Andreani, A; Granaiola, M; Leoni, A; Locatelli, A; Morigi, R; Rambaldi, M; Varoli, L; Lannigan, D; Smith, J; Scudiero, D; Kondapaka, S; Shoemaker, RH Universit£ di Bologna http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50355591 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50355591&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 57402527 136959615 CHEMBL1910600 ZINC73139389 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50697988 NC(=N)N\N=C/c1c(nc2sccn12)-c1cc(F)c(F)cc1F InChI=1S/C13H9F3N6S/c14-7-4-9(16)8(15)3-6(7)11-10(5-19-21-12(17)18)22-1-2-23-13(22)20-11/h1-5H,(H4,17,18,21)/b19-5- TUHHHQNHRGUXPV-IPKBDRFQSA-N 50355592 CHEMBL1910601 Ribosomal protein S6 kinase alpha-3 Homo sapiens >100000 ChEMBL 10.1016/j.ejmech.2011.07.001 10.7270/Q2NG4R1D 21794960 Andreani, A; Granaiola, M; Leoni, A; Locatelli, A; Morigi, R; Rambaldi, M; Varoli, L; Lannigan, D; Smith, J; Scudiero, D; Kondapaka, S; Shoemaker, RH Universit£ di Bologna http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50355592 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50355592&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 57399029 136959616 CHEMBL1910601 ZINC73139391 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50697989 NC(=N)N\N=C/c1c(nc2sccn12)-c1ccc(F)c(c1)[N+]([O-])=O InChI=1S/C13H10FN7O2S/c14-8-2-1-7(5-9(8)21(22)23)11-10(6-17-19-12(15)16)20-3-4-24-13(20)18-11/h1-6H,(H4,15,16,19)/b17-6- LJYYODHTWOGGCX-FMQZQXMHSA-N 50355593 CHEMBL1910602 Ribosomal protein S6 kinase alpha-3 Homo sapiens 53750 ChEMBL 10.1016/j.ejmech.2011.07.001 10.7270/Q2NG4R1D 21794960 Andreani, A; Granaiola, M; Leoni, A; Locatelli, A; Morigi, R; Rambaldi, M; Varoli, L; Lannigan, D; Smith, J; Scudiero, D; Kondapaka, S; Shoemaker, RH Universit£ di Bologna http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50355593 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50355593&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 57395516 136959617 CHEMBL1910602 ZINC73140228 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50697990 NC(=N)N\N=C/c1c(nc2sccn12)-c1cccc(c1F)[N+]([O-])=O InChI=1S/C13H10FN7O2S/c14-10-7(2-1-3-8(10)21(22)23)11-9(6-17-19-12(15)16)20-4-5-24-13(20)18-11/h1-6H,(H4,15,16,19)/b17-6- NYOMGULVYWUWGN-FMQZQXMHSA-N 50355594 CHEMBL1910603 Ribosomal protein S6 kinase alpha-3 Homo sapiens >100000 ChEMBL 10.1016/j.ejmech.2011.07.001 10.7270/Q2NG4R1D 21794960 Andreani, A; Granaiola, M; Leoni, A; Locatelli, A; Morigi, R; Rambaldi, M; Varoli, L; Lannigan, D; Smith, J; Scudiero, D; Kondapaka, S; Shoemaker, RH Universit£ di Bologna http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50355594 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50355594&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 57395518 136959618 CHEMBL1910603 ZINC73293881 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50697991 NC(=N)N\N=C/c1c(nc2sccn12)-c1cccc(c1)C(F)(F)F InChI=1S/C14H11F3N6S/c15-14(16,17)9-3-1-2-8(6-9)11-10(7-20-22-12(18)19)23-4-5-24-13(23)21-11/h1-7H,(H4,18,19,22)/b20-7- WTQLRECSUZDYRV-SCDVKCJHSA-N 50355595 CHEMBL1910604 Ribosomal protein S6 kinase alpha-3 Homo sapiens >100000 ChEMBL 10.1016/j.ejmech.2011.07.001 10.7270/Q2NG4R1D 21794960 Andreani, A; Granaiola, M; Leoni, A; Locatelli, A; Morigi, R; Rambaldi, M; Varoli, L; Lannigan, D; Smith, J; Scudiero, D; Kondapaka, S; Shoemaker, RH Universit£ di Bologna http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50355595 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50355595&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 57395520 136959619 CHEMBL1910604 ZINC73140579 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50697992 Clc1cc(c(Cl)s1)-c1nc2ccccn2c1C=NN=C1NCCN1 InChI=1S/C15H12Cl2N6S/c16-11-7-9(14(17)24-11)13-10(8-20-22-15-18-4-5-19-15)23-6-2-1-3-12(23)21-13/h1-3,6-8H,4-5H2,(H2,18,19,22) ZEDGGXNENVOOSF-UHFFFAOYSA-N 50355596 CHEMBL1910624 Ribosomal protein S6 kinase alpha-3 Homo sapiens >100000 ChEMBL 10.1016/j.ejmech.2011.07.001 10.7270/Q2NG4R1D 21794960 Andreani, A; Granaiola, M; Leoni, A; Locatelli, A; Morigi, R; Rambaldi, M; Varoli, L; Lannigan, D; Smith, J; Scudiero, D; Kondapaka, S; Shoemaker, RH Universit£ di Bologna http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50355596 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50355596&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 54771824 136959620 CHEMBL1910624 ZINC73067708 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50697993 Cc1cn2c(\C=N\NC(=N)NN)c(nc2s1)-c1ccc(Cl)c(c1)[N+]([O-])=O InChI=1S/C14H13ClN8O2S/c1-7-6-22-11(5-18-21-13(16)20-17)12(19-14(22)26-7)8-2-3-9(15)10(4-8)23(24)25/h2-6H,17H2,1H3,(H3,16,20,21)/b18-5+ NHQKYYYCTUJWBY-BLLMUTORSA-N 50355597 CHEMBL1910751 Ribosomal protein S6 kinase alpha-3 Homo sapiens 18000 ChEMBL 10.1016/j.ejmech.2011.07.001 10.7270/Q2NG4R1D 21794960 Andreani, A; Granaiola, M; Leoni, A; Locatelli, A; Morigi, R; Rambaldi, M; Varoli, L; Lannigan, D; Smith, J; Scudiero, D; Kondapaka, S; Shoemaker, RH Universit£ di Bologna http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50355597 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50355597&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 24800837 136959621 CHEMBL1910751 ZINC29133455 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50697994 NC(=N)N\N=C\c1c(nc2sccn12)-c1cccc(c1)[N+]([O-])=O InChI=1S/C13H11N7O2S/c14-12(15)18-16-7-10-11(17-13-19(10)4-5-23-13)8-2-1-3-9(6-8)20(21)22/h1-7H,(H4,14,15,18)/b16-7+ UDQKLBNAKBHTTN-FRKPEAEDSA-N 50355598 CHEMBL1910752 Ribosomal protein S6 kinase alpha-3 Homo sapiens 18500 ChEMBL 10.1016/j.ejmech.2011.07.001 10.7270/Q2NG4R1D 21794960 Andreani, A; Granaiola, M; Leoni, A; Locatelli, A; Morigi, R; Rambaldi, M; Varoli, L; Lannigan, D; Smith, J; Scudiero, D; Kondapaka, S; Shoemaker, RH Universit£ di Bologna http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50355598 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50355598&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 57402533 136959622 CHEMBL1910752 ZINC05974056 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50697995 Cc1cn2c(\C=N\NC3=[NH+]CC[N-]3)c(nc2s1)-c1ccc(Cl)c(c1)[N+]([O-])=O InChI=1S/C16H13ClN7O2S/c1-9-8-23-13(7-20-22-15-18-4-5-19-15)14(21-16(23)27-9)10-2-3-11(17)12(6-10)24(25)26/h2-3,6-8H,4-5H2,1H3,(H-,18,19,22)/q-1/p+1/b20-7+ CGDWHNFEAAWLFW-IFRROFPPSA-O 50355599 CHEMBL1910753 Ribosomal protein S6 kinase alpha-3 Homo sapiens 20500 ChEMBL 10.1016/j.ejmech.2011.07.001 10.7270/Q2NG4R1D 21794960 Andreani, A; Granaiola, M; Leoni, A; Locatelli, A; Morigi, R; Rambaldi, M; Varoli, L; Lannigan, D; Smith, J; Scudiero, D; Kondapaka, S; Shoemaker, RH Universit£ di Bologna http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50355599 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50355599&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 24204009 136959623 CHEMBL1910753 ZINC29133393 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50829176 N#CC(c1nc2ccccc2s1)c1ccnc(NCCc2cccnc2)n1 InChI=1S/C20H16N6S/c21-12-15(19-25-17-5-1-2-6-18(17)27-19)16-8-11-24-20(26-16)23-10-7-14-4-3-9-22-13-14/h1-6,8-9,11,13,15H,7,10H2,(H,23,24,26) RCYPVQCPYKNSTG-UHFFFAOYSA-N 50169959 2-(benzo[d]thiazol-2(3H)-ylidene)-2-(2-(2-(pyridin-3-yl)ethylamino)pyrimidin-4-yl)acetonitrile::AS-601245::AS601245::CHEMBL1788116::CHEMBL191384::[3H-Benzothiazol-(2Z)-ylidene]-[2-(2-pyridin-3-yl-ethylamino)-pyrimidin-4-yl]-acetonitrile Ribosomal protein S6 kinase alpha-3 Homo sapiens 10000 ChEMBL 10.1021/jm0310986 10.7270/Q2K9389G 15999997 Gaillard, P; Jeanclaude-Etter, I; Ardissone, V; Arkinstall, S; Cambet, Y; Camps, M; Chabert, C; Church, D; Cirillo, R; Gretener, D; Halazy, S; Nichols, A; Szyndralewiez, C; Vitte, PA; Gotteland, JP Serono Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50169959 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50169959&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search JN5 3CY3 10109823 104054707 CHEMBL1788116CHEMBL191384 5997 ZINC13647791 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50840545 C[C@@H]1C[C@H]2CN1CCn1[nH]c3c(cccc3c1=O)-c1nc3c(O2)cccc3[nH]c1=O InChI=1S/C22H21N5O3/c1-12-10-13-11-26(12)8-9-27-22(29)15-5-2-4-14(18(15)25-27)19-21(28)23-16-6-3-7-17(30-13)20(16)24-19/h2-7,12-13,25H,8-11H2,1H3,(H,23,28)/t12-,13+/m1/s1 KBLPHMRCKHFBJB-OLZOCXBDSA-N 50192071 (13R,15S)-13-methyl-16-oxa-8,9,12,22,24-pentaazahexacyclo[15.6.2.1^{6,9}.1^{12,15}.0^{2,7}.0^{21,25}]heptacosa-1(24),2,4,6(27),7,17(25),18,20,22-nonaene-23,27-diol::CHEMBL215803 Ribosomal protein S6 kinase alpha-3 Homo sapiens >1000 ChEMBL 10.1016/j.bmcl.2006.07.026 10.7270/Q2K35VF0 16876403 Kawanishi, N; Sugimoto, T; Shibata, J; Nakamura, K; Masutani, K; Ikuta, M; Hirai, H Banyu Tsukuba Research Institute in collaboration with Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50192071 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50192071&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 1CD 2DS1 16046126 104075026 CHEMBL215803 DB06888 ZINC36770746 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50851773 Clc1cc2NC(=O)Nc3cnc(C#N)c(OCCCCOc2cc1NCc1cncs1)n3 InChI=1S/C20H18ClN7O3S/c21-13-5-15-17(6-14(13)24-9-12-8-23-11-32-12)30-3-1-2-4-31-19-16(7-22)25-10-18(27-19)28-20(29)26-15/h5-6,8,10-11,24H,1-4,9H2,(H2,26,27,28,29) AZTMYWWWILJAKW-UHFFFAOYSA-N 50224883 7-chloro-3-oxo-8-[(thiazol-5-ylmethyl)-amino]-11,16-dioxa-2,4,19,21-tetraaza-tricyclo[15.3.1.0*5,10*]henicosa-1(21),5,7,9,17,19-hexaene-18-crbonitrile::CHEMBL248757 Ribosomal protein S6 kinase alpha-3 Homo sapiens >7368 ChEMBL 10.1016/j.bmcl.2007.09.063 10.7270/Q2X067WT 17935989 Tao, ZF; Chen, Z; Bui, MH; Kovar, P; Johnson, E; Bouska, J; Zhang, H; Rosenberg, S; Sowin, T; Lin, NH Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50224883 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50224883&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 44444843 104096404 CHEMBL248757 ZINC28963230 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50850687 CN(C)c1nc2CCn3cc(C4=C(C(=O)NC4=O)c4cn(CCCc1cc2)c1ccccc41)c1ccccc31 InChI=1S/C32H29N5O2/c1-35(2)30-20-8-7-16-36-18-24(22-9-3-5-11-26(22)36)28-29(32(39)34-31(28)38)25-19-37(17-15-21(33-30)14-13-20)27-12-6-4-10-23(25)27/h3-6,9-14,18-19H,7-8,15-17H2,1-2H3,(H,34,38,39) ZVYLAQPDMUKXOT-UHFFFAOYSA-N 50371215 CHEMBL1162963 Ribosomal protein S6 kinase alpha-3 Homo sapiens 48 ChEMBL 10.1016/j.bmcl.2007.02.059 10.7270/Q2SF2X1M 17350261 Zhang, HC; Bonaga, LV; Ye, H; Derian, CK; Damiano, BP; Maryanoff, BE Johnson & Johnson Pharmaceutical Research & Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50371215 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50371215&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 46905987 160850316 CHEMBL1162963 ZINC49807649 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50870852 CCN(CC)CCNC(=O)c1c(C)[nH]c(\C=C2/C(=O)Nc3ccc(F)cc23)c1C InChI=1S/C22H27FN4O2/c1-5-27(6-2)10-9-24-22(29)20-13(3)19(25-14(20)4)12-17-16-11-15(23)7-8-18(16)26-21(17)28/h7-8,11-12,25H,5-6,9-10H2,1-4H3,(H,24,29)(H,26,28)/b17-12- WINHZLLDWRZWRT-ATVHPVEESA-N 4814 CHEMBL535::N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide::N-[2-(diethylamino)ethyl]-5-{[(3Z)-5-fluoro-2-oxo-2,3-dihydro-1H-indol-3-ylidene]methyl}-2,4-dimethyl-1H-pyrrole-3-carboxamide::SU11248::SUNITINIB::SUNITINIB MALATE::US10464902, Sunitinib::US9163010, Sunitinib::US9914707, SU11248 Ribosomal protein S6 kinase alpha-3 Homo sapiens 55 ChEMBL 10.1073/pnas.0707498104 10.7270/Q24X58QS 18077425 McDermott, U; Sharma, SV; Dowell, L; Greninger, P; Montagut, C; Lamb, J; Archibald, H; Raudales, R; Tam, A; Lee, D; Rothenberg, SM; Supko, JG; Sordella, R; Ulkus, LE; Iafrate, AJ; Maheswaran, S; Njauw, CN; Tsao, H; Drew, L; Hanke, JH; Ma, XJ; Erlander, MG; Gray, NS; Haber, DA; Settleman, J Harvard Medical School http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=4814 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=4814&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search B49 6NG0,4KS8,3G0F,3G0E,2Y7J,6JOK,6M11,3MIY,3TI1,4QMZ,6V0X,6NFZ,6NFY,4AGD 5329102 8034462 38940 CHEMBL535 DB01268 5713 ZINC03964325 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50879727 C[C@@H]1CCN(C[C@@H]1N(C)c1ncnc2[nH]ccc12)C(=O)CC#N InChI=1S/C16H20N6O/c1-11-5-8-22(14(23)3-6-17)9-13(11)21(2)16-12-4-7-18-15(12)19-10-20-16/h4,7,10-11,13H,3,5,8-9H2,1-2H3,(H,18,19,20)/t11-,13+/m1/s1 UJLAWZDWDVHWOW-YPMHNXCESA-N 50193995 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile::3-(4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile::3-{(3R,4R)-4-methyl-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}-3-oxopropanenitrile::CHEMBL221959::CP-690550::TOFACITINIB CITRATE::Tofacitinib::Tofacitinib citrate (1)::US10112907, Example 00035::US10399979, Compound Tofacitinib::US10766894, Compound TABLE 1.20::US10875847, Compound Tofacitinib::US11078206, Example Tofacitinib::US11203595, TABLE 1.20::US11339167, Example Tofacitinib Ribosomal protein S6 kinase alpha-3 Homo sapiens >10000 ChEMBL 10.1126/science.1087061 10.7270/Q22Z16FK 14593182 Changelian, PS; Flanagan, ME; Ball, DJ; Kent, CR; Magnuson, KS; Martin, WH; Rizzuti, BJ; Sawyer, PS; Perry, BD; Brissette, WH; McCurdy, SP; Kudlacz, EM; Conklyn, MJ; Elliott, EA; Koslov, ER; Fisher, MB; Strelevitz, TJ; Yoon, K; Whipple, DA; Sun, J; Munchhof, MJ; Doty, JL; Casavant, JM; Blumenkopf, TA; Hines, M; Brown, MF; Lillie, BM; Subramanyam, C; Shang-Poa, C; Milici, AJ; Beckius, GE; Moyer, JD; Su, C; Woodworth, TG; Gaweco, AS; Beals, CR; Littman, BH; Fisher, DA; Smith, JF; Zagouras, P; Magna, HA; Saltarelli, MJ; Johnson, KS; Nelms, LF; Des Etages, SG; Hayes, LS; Kawabata, TT; Finco-Kent, D; Baker, DL; Larson, M; Si, MS; Paniagua, R; Higgins, J; Holm, B; Reitz, B; Zhou, YJ; Morris, RE; O'Shea, JJ; Borie, DC Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50193995 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50193995&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search MI1 3LXK,3LXN,4OTI,3EYG,3FUP 9926791 104076339 71200 CHEMBL221959 DB08183 5677 ZINC03818808 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50900928 Cc1ccc(F)c(NC(=O)Nc2ccc(cc2)-c2cccc3[nH]nc(N)c23)c1 InChI=1S/C21H18FN5O/c1-12-5-10-16(22)18(11-12)25-21(28)24-14-8-6-13(7-9-14)15-3-2-4-17-19(15)20(23)27-26-17/h2-11H,1H3,(H3,23,26,27)(H2,24,25,28) MPVGZUGXCQEXTM-UHFFFAOYSA-N 21079 1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-(2-fluoro-5-methyl-phenyl)urea::1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-(2-fluoro-5-methylphenyl)urea::1-[4-(3-azanyl-1H-indazol-4-yl)phenyl]-3-(2-fluoranyl-5-methyl-phenyl)urea::3-[4-(3-amino-1H-indazol-4-yl)phenyl]-1-(2-fluoro-5-methylphenyl)urea::ABT-869::Aminoindazole, 3::CHEMBL223360::cid_11485656 Ribosomal protein S6 kinase alpha-3 Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=21079 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=21079&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 11485656 49689152 CHEMBL223360 5657 ZINC06718813 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50900929 CC1(C)CNc2cc(NC(=O)c3cccnc3NCc3ccncc3)ccc12 InChI=1S/C22H23N5O/c1-22(2)14-26-19-12-16(5-6-18(19)22)27-21(28)17-4-3-9-24-20(17)25-13-15-7-10-23-11-8-15/h3-12,26H,13-14H2,1-2H3,(H,24,25)(H,27,28) RAHBGWKEPAQNFF-UHFFFAOYSA-N 24773 AMG 706::AMG-706::Motesanib::N-(3,3-dimethyl-1,2-dihydroindol-6-yl)-2-(pyridin-4-ylmethylamino)-3-pyridinecarboxamide::N-(3,3-dimethyl-1,2-dihydroindol-6-yl)-2-(pyridin-4-ylmethylamino)pyridine-3-carboxamide::N-(3,3-dimethyl-2,3-dihydro-1H-indol-6-yl)-2-[(pyridin-4-ylmethyl)amino]pyridine-3-carboxamide::N-(3,3-dimethylindolin-6-yl)-2-(4-pyridylmethylamino)nicotinamide::US10464902, Motesanib::cid_11667893 Ribosomal protein S6 kinase alpha-3 Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=24773 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=24773&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 706 3EFL 11667893 56269724 51098 5660 ZINC18710082 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50900930 CCN1CCN(Cc2ccc(NC(=O)Nc3ccc(Oc4cc(NC)ncn4)cc3)cc2C(F)(F)F)CC1 InChI=1S/C26H30F3N7O2/c1-3-35-10-12-36(13-11-35)16-18-4-5-20(14-22(18)26(27,28)29)34-25(37)33-19-6-8-21(9-7-19)38-24-15-23(30-2)31-17-32-24/h4-9,14-15,17H,3,10-13,16H2,1-2H3,(H,30,31,32)(H2,33,34,37) ODPGGGTTYSGTGO-UHFFFAOYSA-N 31085 1-[4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-3-[4-[[6-(methylamino)-4-pyrimidinyl]oxy]phenyl]urea::1-[4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-3-[4-[6-(methylamino)pyrimidin-4-yl]oxyphenyl]urea::1-[4-[(4-ethylpiperazino)methyl]-3-(trifluoromethyl)phenyl]-3-[4-[6-(methylamino)pyrimidin-4-yl]oxyphenyl]urea::AST-487::cid_11409972 Ribosomal protein S6 kinase alpha-3 Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31085 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31085&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 11409972 252615335 5661 ZINC23247639 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50900931 CCN(CCO)CCCOc1ccc2c(Nc3cc(CC(=O)Nc4cccc(F)c4)n[nH]3)ncnc2c1 InChI=1S/C26H30FN7O3/c1-2-34(10-11-35)9-4-12-37-21-7-8-22-23(16-21)28-17-29-26(22)31-24-14-20(32-33-24)15-25(36)30-19-6-3-5-18(27)13-19/h3,5-8,13-14,16-17,35H,2,4,9-12,15H2,1H3,(H,30,36)(H2,28,29,31,32,33) QYZOGCMHVIGURT-UHFFFAOYSA-N 26300 2-{3-[(7-{3-[ethyl(2-hydroxyethyl)amino]propoxy}quinazolin-4-yl)amino]-1H-pyrazol-5-yl}-N-(3-fluorophenyl)acetamide::CHEMBL215152::cid_16007391::pyrazoloquinazoline deriv., 34 Ribosomal protein S6 kinase alpha-3 Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26300 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26300&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search YJA 4C2V 16007391 56464737 CHEMBL215152 5663 ZINC16697102 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50900932 Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(OCCN2CCOCC2)c2ccccc12)C(C)(C)C InChI=1S/C31H37N5O3/c1-22-9-11-23(12-10-22)36-29(21-28(34-36)31(2,3)4)33-30(37)32-26-13-14-27(25-8-6-5-7-24(25)26)39-20-17-35-15-18-38-19-16-35/h5-14,21H,15-20H2,1-4H3,(H2,32,33,37) MVCOAUNKQVWQHZ-UHFFFAOYSA-N 13533 1-[2-(4-methylphenyl)-5-tert-butyl-pyrazol-3-yl]-3-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea::1-[5-tert-butyl-2-(4-methylphenyl)-3-pyrazolyl]-3-[4-[2-(4-morpholinyl)ethoxy]-1-naphthalenyl]urea::1-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea::1-[5-tert-butyl-2-(p-tolyl)pyrazol-3-yl]-3-[4-(2-morpholinoethoxy)-1-naphthyl]urea::3-[2-(4-methylphenyl)-5-tert-butyl-pyrazol-3-yl]-1-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea::3-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]-1-{4-[2-(morpholin-4-yl)ethoxy]naphthalen-1-yl}urea::BIRB 796::BIRB-796::BIRB-796, 3::CHEMBL103667::D3RKN_73::Doramapimod::US11407771, Compound 43::US8933228, BIRB 796::US9187470, 43 (BIRB-796)::US9242960, BIRB 796::US9260410, BIRB796::cid_156422::diaryl urea compound 10 Ribosomal protein S6 kinase alpha-3 Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13533 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13533&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search B96 4JVG,1KV2,6GTT,5N66,4TWN,3NPC,3FZS 156422 46513934 CHEMBL103667 DB03044 5668 ZINC24044436 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50900933 CC(C)(C)c1cnc(CSc2cnc(NC(=O)C3CCNCC3)s2)o1 InChI=1S/C17H24N4O2S2/c1-17(2,3)12-8-19-13(23-12)10-24-14-9-20-16(25-14)21-15(22)11-4-6-18-7-5-11/h8-9,11,18H,4-7,10H2,1-3H3,(H,20,21,22) OUSFTKFNBAZUKL-UHFFFAOYSA-N 5931 BMS-387072::CHEMBL296468::N-(5-{[(5-tert-butyl-1,3-oxazol-2-yl)methyl]sulfanyl}-1,3-thiazol-2-yl)piperidine-4-carboxamide::N-[5-[[[5-(1,1-Dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4-piperidinecarboxamide::cid_3025986 Ribosomal protein S6 kinase alpha-3 Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=5931 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=5931&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 56H 5D1J 3025986 8035540 CHEMBL296468 5670 ZINC03816409 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50900934 CN1CCN(CC1)c1ccc2nc([nH]c2c1)-c1c(N)c2c(F)cccc2[nH]c1=O InChI=1S/C21H21FN6O/c1-27-7-9-28(10-8-27)12-5-6-14-16(11-12)25-20(24-14)18-19(23)17-13(22)3-2-4-15(17)26-21(18)29/h2-6,11H,7-10H2,1H3,(H,24,25)(H3,23,26,29) PIQCTGMSNWUMAF-UHFFFAOYSA-N 25118 (3Z)-4-amino-5-fluoro-3-[5-(4-methylpiperazino)-1,3-dihydrobenzimidazol-2-ylidene]carbostyril::4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-1,3-benzodiazol-2-yl]-1,2-dihydroquinolin-2-one::CHEMBL522892::CHIR-258 Ribosomal protein S6 kinase alpha-3 Homo sapiens 5600 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25118 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25118&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 9886808 56374260 CHEMBL522892 5962 ZINC03816310 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50900935 Cn1c(Nc2ccc(cc2)C(F)(F)F)nc2cc(Oc3ccnc(c3)-c3ncc([nH]3)C(F)(F)F)ccc12 InChI=1S/C24H16F6N6O/c1-36-19-7-6-15(10-17(19)34-22(36)33-14-4-2-13(3-5-14)23(25,26)27)37-16-8-9-31-18(11-16)21-32-12-20(35-21)24(28,29)30/h2-12H,1H3,(H,32,35)(H,33,34) YABJJWZLRMPFSI-UHFFFAOYSA-N 31088 1-methyl-5-[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]pyridin-4-yl]oxy-N-[4-(trifluoromethyl)phenyl]benzimidazol-2-amine::1-methyl-5-[[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]-4-pyridinyl]oxy]-N-[4-(trifluoromethyl)phenyl]-2-benzimidazolamine::CHIR-265::[1-methyl-5-[[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]-4-pyridyl]oxy]benzimidazol-2-yl]-[4-(trifluoromethyl)phenyl]amine::cid_11656518 Ribosomal protein S6 kinase alpha-3 Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31088 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31088&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 55J 5CT7 11656518 252615336 5674 ZINC18710085 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50900936 Fc1ccc(Nc2ncnc3cc(OCCCN4CCOCC4)c(NC(=O)C=C)cc23)cc1Cl InChI=1S/C24H25ClFN5O3/c1-2-23(32)30-21-13-17-20(14-22(21)34-9-3-6-31-7-10-33-11-8-31)27-15-28-24(17)29-16-4-5-19(26)18(25)12-16/h2,4-5,12-15H,1,3,6-11H2,(H,30,32)(H,27,28,29) OMZCMEYTWSXEPZ-UHFFFAOYSA-N 4779 CHEMBL31965::CHEMBL545315::CI-1033::Canertinib::N-{4-[(3-chloro-4-fluorophenyl)amino]-7-[3-(morpholin-4-yl)propoxy]quinazolin-6-yl}prop-2-enamide::PD0183805::US10507209, Compound CI-1033::US9730934, CI-1033::cid_156414 Ribosomal protein S6 kinase alpha-3 Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=4779 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=4779&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 156414 8034429 61399 CHEMBL31965CHEMBL545315 DB05424 5675 ZINC27439698 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50900937 C[C@@H]1CCN(C[C@@H]1N(C)c1ncnc2[nH]ccc12)C(=O)CC#N InChI=1S/C16H20N6O/c1-11-5-8-22(14(23)3-6-17)9-13(11)21(2)16-12-4-7-18-15(12)19-10-20-16/h4,7,10-11,13H,3,5,8-9H2,1-2H3,(H,18,19,20)/t11-,13+/m1/s1 UJLAWZDWDVHWOW-YPMHNXCESA-N 50193995 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile::3-(4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile::3-{(3R,4R)-4-methyl-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}-3-oxopropanenitrile::CHEMBL221959::CP-690550::TOFACITINIB CITRATE::Tofacitinib::Tofacitinib citrate (1)::US10112907, Example 00035::US10399979, Compound Tofacitinib::US10766894, Compound TABLE 1.20::US10875847, Compound Tofacitinib::US11078206, Example Tofacitinib::US11203595, TABLE 1.20::US11339167, Example Tofacitinib Ribosomal protein S6 kinase alpha-3 Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50193995 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50193995&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search MI1 3LXK,3LXN,4OTI,3EYG,3FUP 9926791 104076339 71200 CHEMBL221959 DB08183 5677 ZINC03818808 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50900938 COCC(=O)NC\C=C\c1ccc2ncnc(Nc3ccc(Oc4ccc(C)nc4)c(C)c3)c2c1 InChI=1S/C27H27N5O3/c1-18-13-21(8-11-25(18)35-22-9-6-19(2)29-15-22)32-27-23-14-20(7-10-24(23)30-17-31-27)5-4-12-28-26(33)16-34-3/h4-11,13-15,17H,12,16H2,1-3H3,(H,28,33)(H,30,31,32)/b5-4+ LLVZBTWPGQVVLW-SNAWJCMRSA-N 31340 2-methoxy-N-[(E)-3-[4-[3-methyl-4-(6-methylpyridin-3-yl)oxyanilino]quinazolin-6-yl]prop-2-enyl]acetamide::2-methoxy-N-[(E)-3-[4-[3-methyl-4-[(6-methyl-3-pyridinyl)oxy]anilino]-6-quinazolinyl]prop-2-enyl]acetamide::2-methoxy-N-[(E)-3-[4-[3-methyl-4-[(6-methyl-3-pyridyl)oxy]anilino]quinazolin-6-yl]allyl]acetamide::2-methoxy-N-[(E)-3-[4-[[3-methyl-4-(6-methylpyridin-3-yl)oxy-phenyl]amino]quinazolin-6-yl]prop-2-enyl]ethanamide::CHEMBL483321::CP-724714::cid_9874913 Ribosomal protein S6 kinase alpha-3 Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31340 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31340&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 9874913 252615341 CHEMBL483321 ZINC03817105 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50900939 Cc1nc(Nc2ncc(s2)C(=O)Nc2c(C)cccc2Cl)cc(n1)N1CCN(CCO)CC1 InChI=1S/C22H26ClN7O2S/c1-14-4-3-5-16(23)20(14)28-21(32)17-13-24-22(33-17)27-18-12-19(26-15(2)25-18)30-8-6-29(7-9-30)10-11-31/h3-5,12-13,31H,6-11H2,1-2H3,(H,28,32)(H,24,25,26,27) ZBNZXTGUTAYRHI-UHFFFAOYSA-N 13216 BMS-354825::CHEMBL1421::DASATINIB::N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl)]-2-methyl-4-pyrimidinyl]amino)]-1,3-thiazole-5-carboxamide::N-(2-chloro-6-methylphenyl)-2-({6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl}amino)-1,3-thiazole-5-carboxamide::US10294227, Code Dasatinib::cid_3062316::med.21724, Compound Dasatinib Ribosomal protein S6 kinase alpha-3 Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13216 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13216&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 1N1 5BVW,5OWR,6FNM,6BSD,5I9Y,2ZVA,3OCT,7ERK,3QLG,3SXR,7N9G,4XLI,3OHT,2Y6O,3LFA,4XEY,2GQG,3K54,3G5D,4QMS,5VCV,5H2U 3062316 46513626 49375 CHEMBL1421 DB01254 5678 ZINC21982951 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50900940 CCOc1cc2ncc(C#N)c(Nc3ccc(F)c(Cl)c3)c2cc1NC(=O)\C=C\CN(C)C InChI=1S/C24H23ClFN5O2/c1-4-33-22-12-20-17(11-21(22)30-23(32)6-5-9-31(2)3)24(15(13-27)14-28-20)29-16-7-8-19(26)18(25)10-16/h5-8,10-12,14H,4,9H2,1-3H3,(H,28,29)(H,30,32)/b6-5+ WVUNYSQLFKLYNI-AATRIKPKSA-N 31090 (E)-N-[4-(3-chloro-4-fluoro-anilino)-3-cyano-7-ethoxy-6-quinolyl]-4-(dimethylamino)but-2-enamide::(E)-N-[4-(3-chloro-4-fluoroanilino)-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-2-butenamide::(E)-N-[4-(3-chloro-4-fluoroanilino)-3-cyano-7-ethoxyquinolin-6-yl]-4-(dimethylamino)but-2-enamide::(E)-N-[4-[(3-chloranyl-4-fluoranyl-phenyl)amino]-3-cyano-7-ethoxy-quinolin-6-yl]-4-(dimethylamino)but-2-enamide::EKB-569::Pelitinib::cid_6445562 Ribosomal protein S6 kinase alpha-3 Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31090 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31090&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 93J 7AXM,5VCW 6445562 252615337 38927 ZINC00602803 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50900941 COCCOc1cc2ncnc(Nc3cccc(c3)C#C)c2cc1OCCOC InChI=1S/C22H23N3O4/c1-4-16-6-5-7-17(12-16)25-22-18-13-20(28-10-8-26-2)21(29-11-9-27-3)14-19(18)23-15-24-22/h1,5-7,12-15H,8-11H2,2-3H3,(H,23,24,25) AAKJLRGGTJKAMG-UHFFFAOYSA-N 5446 CHEMBL553::ERLOTINIB HYDROCHLORIDE::Erlotinib::Erotinib::N-(3-Ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine Monohydrochloride::N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine::OSI-774::Tarceva::US10189853, erlotinib::US10507209, Compound Erlotinib::US11524945, Compound Erlotinib::US9409845, Table 1, Compound 22: erlotinib::US9730934, Erlotinib::WO2022090481, Example erlotinib::cid_176870 Ribosomal protein S6 kinase alpha-3 Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=5446 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=5446&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search AQ4 4HJO,6DWN,1M17 176870 8035065 114785 CHEMBL553 DB00530 4920 ZINC01546066 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50900942 CN1CC[C@@H]([C@H](O)C1)c1c(O)cc(O)c2c1oc(cc2=O)-c1ccccc1Cl InChI=1S/C21H20ClNO5/c1-23-7-6-12(17(27)10-23)19-14(24)8-15(25)20-16(26)9-18(28-21(19)20)11-4-2-3-5-13(11)22/h2-5,8-9,12,17,24-25,27H,6-7,10H2,1H3/t12-,17+/m0/s1 BIIVYFLTOXDAOV-YVEFUNNKSA-N 5655 2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methylpiperidin-4-yl]-4H-chromen-4-one::CHEMBL428690::Flavopiridol::US10294218, Example Flavopiridol::US9617225, Flavopiridol Ribosomal protein S6 kinase alpha-3 Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=5655 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=5655&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search CPB 1C8K,1E1Y,3BLR,3EBP,4O71 5287969 8035270 CHEMBL428690 DB03496 5680 ZINC21288966 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50900943 COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1OCCCN1CCOCC1 InChI=1S/C22H24ClFN4O3/c1-29-20-13-19-16(12-21(20)31-8-2-5-28-6-9-30-10-7-28)22(26-14-25-19)27-15-3-4-18(24)17(23)11-15/h3-4,11-14H,2,5-10H2,1H3,(H,25,26,27) XGALLCVXEZPNRQ-UHFFFAOYSA-N 5447 CHEMBL939::GEFITINIB::Iressa::N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-[3-(4-morpholinyl)propoxy]-4-quinazolinamine::N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[3-(morpholin-4-yl)propoxy]quinazolin-4-amine::US10106508, Gefitinib::US10507209, Compound Gefitinib::US9416123, Gefitinib::US9730934, Gefitinib::US9783524, Gefitinib::WO2022090481, Example gefitinib::ZD1839::cid_123631 Ribosomal protein S6 kinase alpha-3 Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=5447 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=5447&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 2ITO,2ITY,2ITZ 123631 8035066 49668 CHEMBL939 DB00317 4941 ZINC19632614 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50900944 COc1ccc(COc2ccc(Cc3cnc(N)nc3N)cc2OC)cc1 InChI=1S/C20H22N4O3/c1-25-16-6-3-13(4-7-16)12-27-17-8-5-14(10-18(17)26-2)9-15-11-23-20(22)24-19(15)21/h3-8,10-11H,9,12H2,1-2H3,(H4,21,22,23,24) MYQAUKPBNJWPIE-UHFFFAOYSA-N 32362 5-[[3-methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]methyl]pyrimidine-2,4-diamine::GW-2580::[2-amino-5-(3-methoxy-4-p-anisyloxy-benzyl)pyrimidin-4-yl]amine::cid_11617559 Ribosomal protein S6 kinase alpha-3 Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=32362 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=32362&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search MUJ 4AT5 11617559 252615797 5685 ZINC13985942 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50900945 CN(c1ccc2c(C)n(C)nc2c1)c1ccnc(Nc2ccc(C)c(c2)S(N)(=O)=O)n1 InChI=1S/C21H23N7O2S/c1-13-5-6-15(11-19(13)31(22,29)30)24-21-23-10-9-20(25-21)27(3)16-7-8-17-14(2)28(4)26-18(17)12-16/h5-12H,1-4H3,(H2,22,29,30)(H,23,24,25) CUIHSIWYWATEQL-UHFFFAOYSA-N 26474 5-({4-[(2,3-dimethyl-2H-indazol-6-yl)(methyl)amino]pyrimidin-2-yl}amino)-2-methylbenzene-1-sulfonamide::GW-786034::JMC514632 Compound 13::Pazopanib::cid_10113978 Ribosomal protein S6 kinase alpha-3 Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26474 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26474&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 10113978 56464911 71219 DB06589 5698 ZINC11617039 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50900946 CN1CCN(Cc2ccc(cc2)C(=O)Nc2ccc(C)c(Nc3nccc(n3)-c3cccnc3)c2)CC1 InChI=1S/C29H31N7O/c1-21-5-10-25(18-27(21)34-29-31-13-11-26(33-29)24-4-3-12-30-19-24)32-28(37)23-8-6-22(7-9-23)20-36-16-14-35(2)15-17-36/h3-13,18-19H,14-17,20H2,1-2H3,(H,32,37)(H,31,33,34) KTUFNOKKBVMGRW-UHFFFAOYSA-N 13530 4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]benzamide::CHEMBL941::Gleevec::Imatinib::Imatinib, 21::N-(4-methyl-3-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}phenyl)-4-[(4-methylpiperazin-1-yl)methyl]benzamide::STI-571::STI571::US10906896, Cpd imatinib::US11649218, Example Imatinib::US9255107, Imatinib::cid_5291::imatinib-CD3::med.21724, Compound 6 Ribosomal protein S6 kinase alpha-3 Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13530 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13530&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search STI 6HD6,6HD4,2HYY,4BKJ,2PL0,3GVU,6NPU,6NPV,6NPE,4CSV,3MS9,3MSS,4R7I,7N9G,2OIQ,1IEP,1XBB,3HEC,1T46,3FW1,3PYY,6VXH,6JOL,3K5V,5MQT,3OEZ,6KTN,1OPJ 5291 46513933 45783 CHEMBL941 DB00619 5687 ZINC19632618 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50900947 Nc1nc(Nc2ccc(cc2)S(N)(=O)=O)nn1C(=O)c1c(F)cccc1F InChI=1S/C15H12F2N6O3S/c16-10-2-1-3-11(17)12(10)13(24)23-14(18)21-15(22-23)20-8-4-6-9(7-5-8)27(19,25)26/h1-7H,(H2,19,25,26)(H3,18,20,21,22) KDKUVYLMPJIGKA-UHFFFAOYSA-N 6866 1-Acyl-1H-[1,2,4]triazole-3,5-diamine Analogue 3b::4-({5-amino-1-[(2,6-difluorophenyl)carbonyl]-1H-1,2,4-triazol-3-yl}amino)benzene-1-sulfonamide::4-[[5-Amino-1-(2,6-difluorobenzoyl)-1H-1,2,4-triazol-3-yl]amino]-benzenesulfonamide::CHEMBL191003::JNJ-7706621::cid_5330790 Ribosomal protein S6 kinase alpha-3 Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=6866 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=6866&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search SKE 5WIN,5USZ,5USY,5DR9,8B99,5OBR,6DRW,5DPV,5DR6,6P11,6P10,3AMA,4QMU,5DT0 5330790 8036422 CHEMBL191003 ZINC03938688 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50900948 CS(=O)(=O)CCNCc1ccc(o1)-c1ccc2ncnc(Nc3ccc(OCc4cccc(F)c4)c(Cl)c3)c2c1 InChI=1S/C29H26ClFN4O4S/c1-40(36,37)12-11-32-16-23-7-10-27(39-23)20-5-8-26-24(14-20)29(34-18-33-26)35-22-6-9-28(25(30)15-22)38-17-19-3-2-4-21(31)13-19/h2-10,13-15,18,32H,11-12,16-17H2,1H3,(H,33,34,35) BCFGMOOMADDAQU-UHFFFAOYSA-N 5445 CHEMBL554::GW572016::LAPATINIB DITOSYLATE::Lapatinib::N-{3-chloro-4-[(3-fluoro-benzyl)oxy]phenyl}-6-[5-({2-(methylsulfonyl)ethyl]amino}methyl)-2-furyl]-4-quinazolinamine::N-{3-chloro-4-[(3-fluorophenyl)methoxy]phenyl}-6-(5-{[(2-methanesulfonylethyl)amino]methyl}furan-2-yl)quinazolin-4-amine::Tykerb::US10507209, Compound Lapatinib::US10822334, Compound Lapatinib::US9730934, Lapatinib ditosylate::cid_208908 Ribosomal protein S6 kinase alpha-3 Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=5445 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=5445&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search FMM 1XKK,3BBT 208908 8035064 49603 CHEMBL554 DB01259 5692 ZINC01550477 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50900949 CN(C)C[C@@H]1CCn2cc(C3=C(C(=O)NC3=O)c3cn(CCO1)c1ccccc31)c1ccccc21 InChI=1S/C28H28N4O3/c1-30(2)15-18-11-12-31-16-21(19-7-3-5-9-23(19)31)25-26(28(34)29-27(25)33)22-17-32(13-14-35-18)24-10-6-4-8-20(22)24/h3-10,16-18H,11-15H2,1-2H3,(H,29,33,34)/t18-/m0/s1 ZCBUQCWBWNUWSU-SFHVURJKSA-N 17055 (18S)-18-[(dimethylamino)methyl]-17-oxa-4,14,21-triazahexacyclo[19.6.1.1^{7,14}.0^{2,6}.0^{8,13}.0^{22,27}]nonacosa-1(28),2(6),7(29),8(13),9,11,22(27),23,25-nonaene-3,5-dione::(9S)-9-[(dimethylamino)methyl]-6,7,10,11-tetrahydro-9H,18H-5,21:12,17-di(metheno)dibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecine-18,20(19H)-dione::K00587a::LY 333531::LY-333531::LY333531::Ruboxistaurin::cid_153999 Ribosomal protein S6 kinase alpha-3 Homo sapiens 3600 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17055 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17055&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search LY4 2J2I,1UU3 153999 46517285 5263 ZINC03812168 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50900950 COc1cc2c(ncnc2cc1OCCCN1CCCCC1)N1CCN(CC1)C(=O)Nc1ccc(OC(C)C)cc1 InChI=1S/C31H42N6O4/c1-23(2)41-25-10-8-24(9-11-25)34-31(38)37-17-15-36(16-18-37)30-26-20-28(39-3)29(21-27(26)32-22-33-30)40-19-7-14-35-12-5-4-6-13-35/h8-11,20-23H,4-7,12-19H2,1-3H3,(H,34,38) UXXQOJXBIDBUAC-UHFFFAOYSA-N 13535 4-[6-methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin-4-yl]-N-(4-propan-2-yloxyphenyl)piperazine-1-carboxamide::4-[6-methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin-4-yl]-N-[4-(1-methylethoxy)phenyl]piperazine-1-carboxamide::4-[6-methoxy-7-[3-(1-piperidinyl)propoxy]-4-quinazolinyl]-N-(4-propan-2-yloxyphenyl)-1-piperazinecarboxamide::4-{6-methoxy-7-[3-(piperidin-1-yl)propoxy]quinazolin-4-yl}-N-[4-(propan-2-yloxy)phenyl]piperazine-1-carboxamide::CHEMBL124660::MLN-518::MLN518::N-(4-isopropoxyphenyl)-4-[6-methoxy-7-(3-piperidinopropoxy)quinazolin-4-yl]piperazine-1-carboxamide::cid_3038522 Ribosomal protein S6 kinase alpha-3 Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13535 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13535&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 3038522 46513936 CHEMBL124660 DB05465 ZINC03966243 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50900951 OC(=O)c1ccc(Nc2ncc3CN=C(c4cc(Cl)ccc4-c3n2)c2c(F)cccc2F)cc1 InChI=1S/C25H15ClF2N4O2/c26-15-6-9-17-18(10-15)23(21-19(27)2-1-3-20(21)28)29-11-14-12-30-25(32-22(14)17)31-16-7-4-13(5-8-16)24(33)34/h1-10,12H,11H2,(H,33,34)(H,30,31,32) HHFBDROWDBDFBR-UHFFFAOYSA-N 31093 4-[[7-[2,6-bis(fluoranyl)phenyl]-9-chloranyl-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino]benzoic acid::4-[[9-chloro-7-(2,6-difluorophenyl)-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino]benzoic acid::BDBM31832::CHEMBL259084::MLN-8054::cid_11712649 Ribosomal protein S6 kinase alpha-3 Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31093 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31093&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search ZZL 2X81,5IA1,2WTW,2WTV 11712649 252615338 CHEMBL259084 5696 ZINC18825334 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50900952 Oc1cccc(c1)-c1nc(N2CCOCC2)c2oc3ncccc3c2n1 InChI=1S/C19H16N4O3/c24-13-4-1-3-12(11-13)17-21-15-14-5-2-6-20-19(14)26-16(15)18(22-17)23-7-9-25-10-8-23/h1-6,11,24H,7-10H2 TUVCWJQQGGETHL-UHFFFAOYSA-N 25045 3-(4-morpholin-4-ylpyrido[2,3]furo[2,4-b]pyrimidin-2-yl)phenol::3-(4-morpholin-4-ylpyrido[3 ,2 :4,5]furo[3,2-d]pyrimidin-2-yl)phenol::3-(4-morpholinopyrido[2,3]furo[2,4-b]pyrimidin-2-yl)phenol::3-[4-(4-morpholinyl)-2-pyrido[2,3]furo[2,4-b]pyrimidinyl]phenol::3-[6-(morpholin-4-yl)-8-oxa-3,5,10-triazatricyclo[7.4.0.0^{2,7}]trideca-1(9),2,4,6,10,12-hexaen-4-yl]phenol::CHEMBL538346::PI-103::US9637488, PI-103::cid_9884685::mTOR Inhibitor, PI103::pyridofuropyrimidine derivative, 2 Ribosomal protein S6 kinase alpha-3 Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25045 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25045&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search X6K 2X6K,4L23,4JT6 9884685 56374189 CHEMBL538346 5701 ZINC03963016 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50900954 Clc1ccc(Nc2nnc(Cc3ccncc3)c3ccccc23)cc1 InChI=1S/C20H15ClN4/c21-15-5-7-16(8-6-15)23-20-18-4-2-1-3-17(18)19(24-25-20)13-14-9-11-22-12-10-14/h1-12H,13H2,(H,23,25) YCOYDOIWSSHVCK-UHFFFAOYSA-N 4851 (4-chlorophenyl)-[4-(4-pyridylmethyl)phthalazin-1-yl]amine::(A) PTK787::CGP 79787::CHEMBL101253::CHEMBL75232::N-(4-chlorophenyl)-4-(pyridin-4-ylmethyl)-1-phthalazinamine::N-(4-chlorophenyl)-4-(pyridin-4-ylmethyl)phthalazin-1-amine::PTK-787::PTK787::ZK222584::cid_151194 Ribosomal protein S6 kinase alpha-3 Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=4851 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=4851&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 151194 8034494 CHEMBL75232CHEMBL101253 DB04879 6052 ZINC00007460 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50900955 CC[C@H](CO)Nc1nc(NCc2ccccc2)c2ncn(C(C)C)c2n1 InChI=1S/C19H26N6O/c1-4-15(11-26)22-19-23-17(20-10-14-8-6-5-7-9-14)16-18(24-19)25(12-21-16)13(2)3/h5-9,12-13,15,26H,4,10-11H2,1-3H3,(H2,20,22,23,24)/t15-/m1/s1 BTIHMVBBUGXLCJ-OAHLLOKOSA-N 7533 (2R)-2-[[6-(benzylamino)-9-isopropyl-purin-2-yl]amino]butan-1-ol::(2R)-2-[[6-(benzylamino)-9-propan-2-ylpurin-2-yl]amino]butan-1-ol::(2R)-2-[[6-[(phenylmethyl)amino]-9-propan-2-yl-2-purinyl]amino]-1-butanol::(2R)-2-[[6-[(phenylmethyl)amino]-9-propan-2-yl-purin-2-yl]amino]butan-1-ol::(2R)-2-{[6-(benzylamino)-9-(propan-2-yl)-9H-purin-2-yl]amino}butan-1-ol::(R)-Roscovitine::2,6,9-Trisubstituted purine deriv. 28::CHEMBL14762::CYC-202::Roscovitine::cid_160355 Ribosomal protein S6 kinase alpha-3 Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=7533 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=7533&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search RRC 3DDQ,1YGK,2A4L,1UNL 160355 11108321 CHEMBL14762 6035 ZINC01649340 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50900956 Oc1ccc(cc1)-c1nc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1 InChI=1S/C20H14FN3O/c21-16-5-1-13(2-6-16)18-19(14-9-11-22-12-10-14)24-20(23-18)15-3-7-17(25)8-4-15/h1-12,25H,(H,23,24) QHKYPYXTTXKZST-UHFFFAOYSA-N 13531 4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)-1H-imidazole::4-[4-(4-Fluorophenyl)-5-(4-pyridinyl)-1H-imidazol-2-yl]phenol::4-[4-(4-fluorophenyl)-5-(4-pyridyl)-4-imidazolin-2-ylidene]cyclohexa-2,5-dien-1-one::4-[5-(4-fluorophenyl)-4-(pyridin-4-yl)-1H-imidazol-2-yl]phenol::SB-202190::SB202190::biotinylated SB202190 Ribosomal protein S6 kinase alpha-3 Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13531 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13531&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 5353940 172097219 ZINC14951176 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50900957 CS(=O)c1ccc(cc1)-c1nc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1 InChI=1S/C21H16FN3OS/c1-27(26)18-8-4-16(5-9-18)21-24-19(14-2-6-17(22)7-3-14)20(25-21)15-10-12-23-13-11-15/h2-13H,1H3,(H,24,25) CDMGBJANTYXAIV-UHFFFAOYSA-N 13336 4-[4-(4-fluorophenyl)-2-(4-methanesulfinylphenyl)-1H-imidazol-5-yl]pyridine::4-[4-(4-fluorophenyl)-2-(4-methylsulfinylphenyl)-1H-imidazol-5-yl]pyridine::4-{4-(4-fluorophenyl)-2-[4-(methylsulfinyl)phenyl]-1H-imidazol-5-yl}pyridine::CHEMBL10::SB-203580::SB203580::cid_176155 Ribosomal protein S6 kinase alpha-3 Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13336 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13336&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 1A9U,1PME,2EWA 176155 46513744 CHEMBL10 5269 ZINC96006137 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50900958 NC(=O)c1ccc(cc1)-c1nc(c([nH]1)-c1ccc2OCOc2c1)-c1ccccn1 InChI=1S/C22H16N4O3/c23-21(27)13-4-6-14(7-5-13)22-25-19(20(26-22)16-3-1-2-10-24-16)15-8-9-17-18(11-15)29-12-28-17/h1-11H,12H2,(H2,23,27)(H,25,26) FHYUGAJXYORMHI-UHFFFAOYSA-N 50110208 4-(4-(benzo[d][1,3]dioxol-5-yl)-5-(pyridin-2-yl)-1H-imidazol-2-yl)benzamide::4-(4-Benzo[1,3]dioxol-5-yl-5-pyridin-2-yl-1H-imidazol-2-yl)-benzamide::4-(5-(benzo[d][1,3]dioxol-5-yl)-4-(pyridin-2-yl)-1H-imidazol-2-yl)benzamide::4-(5-benzo[1,3]dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)-benzamide::CHEMBL440084::SB-431542::cid_4521392 Ribosomal protein S6 kinase alpha-3 Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50110208 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50110208&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 085 3TZM 4521392 104005054 CHEMBL440084 ZINC00603769 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50900959 CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)cc2)ccn1 InChI=1S/C21H16ClF3N4O3/c1-26-19(30)18-11-15(8-9-27-18)32-14-5-2-12(3-6-14)28-20(31)29-13-4-7-17(22)16(10-13)21(23,24)25/h2-11H,1H3,(H,26,30)(H2,28,29,31) MLDQJTXFUGDVEO-UHFFFAOYSA-N 16673 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)phenoxy]-N-methylpyridine-2-carboxamide::4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methyl-picolinamide;tosylic acid::BAY 43-9006::BAY 439006::BAY439006::CHEMBL1336::Hit compound, 8::Nexavar::Sorafenib::Sorafenib, 4::US10183928, Sorafenib::US10202365, Compound Sorafenib::US10227329, Compound Sorafenib::US10584114, Compound Sorafenib::US10774070, Compound Sorafenib::US10980809, Example Sorafenib::US11279688, Compound Sorafenib::US11505527, Compound Sorafenib::US9029401, Sorafenib::US9469639, Sorafenib::US9902709, Comparative example 1::Xarelto::cid_216239 Ribosomal protein S6 kinase alpha-3 Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=16673 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=16673&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search BAX 3GCS,4ASD,3WZE,5HI2,3HEG,1UWH,1UWJ,3RGF 216239 46516901 50924 CHEMBL1336 DB00398 5711 ZINC01493878 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50900961 Cc1[nH]c(\C=C2/C(=O)Nc3ccc(F)cc23)c(C)c1C(=O)NC[C@H](O)CN1CCOCC1 InChI=1S/C23H27FN4O4/c1-13-20(10-18-17-9-15(24)3-4-19(17)27-22(18)30)26-14(2)21(13)23(31)25-11-16(29)12-28-5-7-32-8-6-28/h3-4,9-10,16,26,29H,5-8,11-12H2,1-2H3,(H,25,31)(H,27,30)/b18-10-/t16-/m0/s1 CTNPALGJUAXMMC-PMFHANACSA-N 31095 5-[(Z)-(5-fluoranyl-2-oxidanylidene-1H-indol-3-ylidene)methyl]-2,4-dimethyl-N-[(2S)-3-morpholin-4-yl-2-oxidanyl-propyl]-1H-pyrrole-3-carboxamide::5-[(Z)-(5-fluoro-2-keto-indolin-3-ylidene)methyl]-N-[(2S)-2-hydroxy-3-morpholino-propyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide::5-[(Z)-(5-fluoro-2-oxo-1H-indol-3-ylidene)methyl]-N-[(2S)-2-hydroxy-3-(4-morpholinyl)propyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide::5-[(Z)-(5-fluoro-2-oxo-1H-indol-3-ylidene)methyl]-N-[(2S)-2-hydroxy-3-morpholin-4-ylpropyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide::SU-14813::cid_10138259 Ribosomal protein S6 kinase alpha-3 Homo sapiens 2100 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31095 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31095&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 10138259 252615339 ZINC18825344 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50900962 CCN(CC)CCNC(=O)c1c(C)[nH]c(\C=C2/C(=O)Nc3ccc(F)cc23)c1C InChI=1S/C22H27FN4O2/c1-5-27(6-2)10-9-24-22(29)20-13(3)19(25-14(20)4)12-17-16-11-15(23)7-8-18(16)26-21(17)28/h7-8,11-12,25H,5-6,9-10H2,1-4H3,(H,24,29)(H,26,28)/b17-12- WINHZLLDWRZWRT-ATVHPVEESA-N 4814 CHEMBL535::N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide::N-[2-(diethylamino)ethyl]-5-{[(3Z)-5-fluoro-2-oxo-2,3-dihydro-1H-indol-3-ylidene]methyl}-2,4-dimethyl-1H-pyrrole-3-carboxamide::SU11248::SUNITINIB::SUNITINIB MALATE::US10464902, Sunitinib::US9163010, Sunitinib::US9914707, SU11248 Ribosomal protein S6 kinase alpha-3 Homo sapiens 580 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=4814 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=4814&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search B49 6NG0,4KS8,3G0F,3G0E,2Y7J,6JOK,6M11,3MIY,3TI1,4QMZ,6V0X,6NFZ,6NFY,4AGD 5329102 8034462 38940 CHEMBL535 DB01268 5713 ZINC03964325 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50900963 CN1CCN(CC1)c1cc(Nc2cc(C)n[nH]2)nc(Sc2ccc(NC(=O)C3CC3)cc2)n1 InChI=1S/C23H28N8OS/c1-15-13-20(29-28-15)25-19-14-21(31-11-9-30(2)10-12-31)27-23(26-19)33-18-7-5-17(6-8-18)24-22(32)16-3-4-16/h5-8,13-14,16H,3-4,9-12H2,1-2H3,(H,24,32)(H2,25,26,27,28,29) GCIKSSRWRFVXBI-UHFFFAOYSA-N 13534 CHEMBL572878::N-[4-({4-[(3-methyl-1H-pyrazol-5-yl)amino]-6-(4-methylpiperazin-1-yl)pyrimidin-2-yl}sulfanyl)phenyl]cyclopropanecarboxamide::N-[4-[[4-(4-methylpiperazino)-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl]thio]phenyl]cyclopropanecarboxamide::VX-680::VX680::cyclopropane carboxylic acid {4-[4-(4-methyl-piperazin-1-yl)-6-(5-methyl-2H-pyrazol-3-ylamino)-pyrimidin-2ylsulphanyl]-phenyl}-amide Ribosomal protein S6 kinase alpha-3 Homo sapiens 6400 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13534 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13534&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search VX6 2F4J,6GR9,6BRJ,3E5A,4ZOG,4B8M,5WNM,3AMB,4JBQ,4AF3,2XYN 5494449 46513935 CHEMBL572878 5718 ZINC03820040 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50900964 Fc1ccc(Sc2ccc3c(-c4c(Cl)cccc4Cl)c(=O)ncn3n2)c(F)c1 InChI=1S/C19H9Cl2F2N3OS/c20-11-2-1-3-12(21)17(11)18-14-5-7-16(25-26(14)9-24-19(18)27)28-15-6-4-10(22)8-13(15)23/h1-9H VEPKQEUBKLEPRA-UHFFFAOYSA-N 15244 5-(2,6-dichlorophenyl)-2-(2,4-difluorophenyl)sulfanylpyrimido[1,6-b]pyridazin-6-one::5-(2,6-dichlorophenyl)-2-[(2,4-difluorophenyl)sulfanyl]-6H-pyrimido[1,6-a]pyridazin-6-one::5-(2,6-dichlorophenyl)-2-[(2,4-difluorophenyl)thio]-6-pyrimido[1,6-b]pyridazinone::5-(2,6-dichlorophenyl)-2-[(2,4-difluorophenyl)thio]pyrimido[1,6-b]pyridazin-6-one::5-(2,6-dichlorophenyl)-9-(2,4-difluorophenyl)sulfanyl-1,3,10-triazabicyclo[4.4.0]deca-2,5,7,9-tetraen-4-one::5-[2,6-bis(chloranyl)phenyl]-2-[2,4-bis(fluoranyl)phenyl]sulfanyl-pyrimido[1,6-b]pyridazin-6-one::VX-745::VX745::cid_3038525 Ribosomal protein S6 kinase alpha-3 Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=15244 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=15244&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 52P 3ZSI,3HP5,3FC1 3038525 46515551 DB07138 ZINC13493055 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50900965 COc1cc2c(Nc3ccc(Br)cc3F)ncnc2cc1OCC1CCN(C)CC1 InChI=1S/C22H24BrFN4O2/c1-28-7-5-14(6-8-28)12-30-21-11-19-16(10-20(21)29-2)22(26-13-25-19)27-18-4-3-15(23)9-17(18)24/h3-4,9-11,13-14H,5-8,12H2,1-2H3,(H,25,26,27) UHTHHESEBZOYNR-UHFFFAOYSA-N 21 CHEMBL24828::N-(4-bromo-2-fluorophenyl)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazolin-4-amine::VANDETANIB::ZD-6474::ZD6474::cid_3081361 Ribosomal protein S6 kinase alpha-3 Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=21 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=21&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search ZD6 2IVU 3081361 8030012 49960 CHEMBL24828 DB08764 ZINC03834198 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50929369 C[C@@H]1O[C@@H](Oc2c(O)c3c(cc(O)cc3=O)oc2-c2ccc(O)cc2)[C@H](O)[C@H](OC(C)=O)[C@H]1OC(C)=O InChI=1S/C25H24O12/c1-10-21(34-11(2)26)24(35-12(3)27)20(32)25(33-10)37-23-19(31)18-16(30)8-15(29)9-17(18)36-22(23)13-4-6-14(28)7-5-13/h4-10,20-21,24-25,28-29,31-32H,1-3H3/t10-,20+,21-,24-,25-/m0/s1 POZDUGKSCAGWQI-IGKKHSBFSA-N 50241294 CHEMBL240954::SL-0101::kaempferol 3-O-(3'',4''-di-O-acetyl-alpha-L-rhamnopyranoside::kaempferol-3-O-(3,4-di-O-acetyl-alpha-L-rhamnopyranoside) Ribosomal protein S6 kinase alpha-3 Homo sapiens 583 ChEMBL 10.1016/j.bmcl.2012.03.033 10.7270/Q2QN67S5 22464132 Hilinski, MK; Mrozowski, RM; Clark, DE; Lannigan, DA University of Virginia http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50241294 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50241294&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 10459196 104098696 CHEMBL240954 ZINC28875874 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50929370 C[C@@H]1O[C@@H](Oc2c(O)c3c(cc(O)cc3=O)oc2-c2ccc(O)cc2)[C@H](O)[C@H](OCC(C)=O)[C@H]1OCC(C)=O InChI=1S/C27H28O12/c1-12(28)10-35-23-14(3)37-27(22(34)25(23)36-11-13(2)29)39-26-21(33)20-18(32)8-17(31)9-19(20)38-24(26)15-4-6-16(30)7-5-15/h4-9,14,22-23,25,27,30-31,33-34H,10-11H2,1-3H3/t14-,22+,23-,25-,27-/m0/s1 JUFRIMNHMISBLW-RFVSBOAQSA-N 50381078 CHEMBL2017518 Ribosomal protein S6 kinase alpha-3 Homo sapiens 252 ChEMBL 10.1016/j.bmcl.2012.03.033 10.7270/Q2QN67S5 22464132 Hilinski, MK; Mrozowski, RM; Clark, DE; Lannigan, DA University of Virginia http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50381078 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50381078&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 60150536 160860161 CHEMBL2017518 ZINC84596657 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50929371 CCNC(=O)O[C@H]1[C@H](C)O[C@@H](Oc2c(O)c3c(cc(O)cc3=O)oc2-c2ccc(O)cc2)[C@H](O)[C@@H]1OC(=O)NCC InChI=1S/C27H30N2O12/c1-4-28-26(35)40-21-12(3)37-25(20(34)24(21)41-27(36)29-5-2)39-23-19(33)18-16(32)10-15(31)11-17(18)38-22(23)13-6-8-14(30)9-7-13/h6-12,20-21,24-25,30-31,33-34H,4-5H2,1-3H3,(H,28,35)(H,29,36)/t12-,20+,21-,24-,25-/m0/s1 UHZOLWKIKYVREI-NIKYMLFTSA-N 50381079 CHEMBL2017517 Ribosomal protein S6 kinase alpha-3 Homo sapiens 1130 ChEMBL 10.1016/j.bmcl.2012.03.033 10.7270/Q2QN67S5 22464132 Hilinski, MK; Mrozowski, RM; Clark, DE; Lannigan, DA University of Virginia http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50381079 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50381079&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 70689587 160860162 CHEMBL2017517 ZINC84596598 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50929372 CCCNC(=O)O[C@H]1[C@H](C)O[C@@H](Oc2c(O)c3c(cc(O)cc3=O)oc2-c2ccc(O)cc2)[C@H](O)[C@@H]1OC(=O)NCCC InChI=1S/C29H34N2O12/c1-4-10-30-28(37)42-23-14(3)39-27(22(36)26(23)43-29(38)31-11-5-2)41-25-21(35)20-18(34)12-17(33)13-19(20)40-24(25)15-6-8-16(32)9-7-15/h6-9,12-14,22-23,26-27,32-33,35-36H,4-5,10-11H2,1-3H3,(H,30,37)(H,31,38)/t14-,22+,23-,26-,27-/m0/s1 DNWFWECBTWLOIT-QHOMFEBYSA-N 50381080 CHEMBL2017519 Ribosomal protein S6 kinase alpha-3 Homo sapiens 869 ChEMBL 10.1016/j.bmcl.2012.03.033 10.7270/Q2QN67S5 22464132 Hilinski, MK; Mrozowski, RM; Clark, DE; Lannigan, DA University of Virginia http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50381080 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50381080&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 60150537 160860163 CHEMBL2017519 ZINC84632331 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50929373 CCC(C)NC(=O)O[C@H]1[C@H](C)O[C@@H](Oc2c(O)c3c(cc(O)cc3=O)oc2-c2ccc(O)cc2)[C@H](O)[C@@H]1OC(=O)NC(C)CC InChI=1S/C31H38N2O12/c1-6-14(3)32-30(39)44-25-16(5)41-29(24(38)28(25)45-31(40)33-15(4)7-2)43-27-23(37)22-20(36)12-19(35)13-21(22)42-26(27)17-8-10-18(34)11-9-17/h8-16,24-25,28-29,34-35,37-38H,6-7H2,1-5H3,(H,32,39)(H,33,40)/t14?,15?,16-,24+,25-,28-,29-/m0/s1 CUCYDSMZEUGYDO-MLJXXPEJSA-N 50381081 CHEMBL2017520 Ribosomal protein S6 kinase alpha-3 Homo sapiens 1920 ChEMBL 10.1016/j.bmcl.2012.03.033 10.7270/Q2QN67S5 22464132 Hilinski, MK; Mrozowski, RM; Clark, DE; Lannigan, DA University of Virginia http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50381081 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50381081&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 60150538 160860164 CHEMBL2017520 ZINC84632453 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50929374 C[C@@H]1O[C@@H](Oc2c(O)c3c(cc(O)cc3=O)oc2-c2ccc(O)cc2)[C@H](O)[C@H](OC(=O)N(C)C)[C@H]1OC(=O)N(C)C InChI=1S/C27H30N2O12/c1-12-21(40-26(35)28(2)3)24(41-27(36)29(4)5)20(34)25(37-12)39-23-19(33)18-16(32)10-15(31)11-17(18)38-22(23)13-6-8-14(30)9-7-13/h6-12,20-21,24-25,30-31,33-34H,1-5H3/t12-,20+,21-,24-,25-/m0/s1 SKRAPUHBZSBPKB-NIKYMLFTSA-N 50381082 CHEMBL2017521 Ribosomal protein S6 kinase alpha-3 Homo sapiens 493 ChEMBL 10.1016/j.bmcl.2012.03.033 10.7270/Q2QN67S5 22464132 Hilinski, MK; Mrozowski, RM; Clark, DE; Lannigan, DA University of Virginia http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50381082 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50381082&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 70691716 160860165 CHEMBL2017521 ZINC84619070 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50929375 C[C@@H]1O[C@@H](Oc2c(O)c3c(cc(O)cc3=O)oc2-c2ccc(O)cc2)[C@H](O)[C@H](OC(=O)N2CCCC2)[C@H]1OC(=O)N1CCCC1 InChI=1S/C31H34N2O12/c1-16-25(44-30(39)32-10-2-3-11-32)28(45-31(40)33-12-4-5-13-33)24(38)29(41-16)43-27-23(37)22-20(36)14-19(35)15-21(22)42-26(27)17-6-8-18(34)9-7-17/h6-9,14-16,24-25,28-29,34-35,37-38H,2-5,10-13H2,1H3/t16-,24+,25-,28-,29-/m0/s1 AXYZTJNCWYAONR-APXYOUHJSA-N 50381083 CHEMBL2017522 Ribosomal protein S6 kinase alpha-3 Homo sapiens 356 ChEMBL 10.1016/j.bmcl.2012.03.033 10.7270/Q2QN67S5 22464132 Hilinski, MK; Mrozowski, RM; Clark, DE; Lannigan, DA University of Virginia http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50381083 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50381083&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 70695907 160860166 CHEMBL2017522 ZINC84619072 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50929376 C[C@@H]1O[C@@H](Oc2c(O)c3c(cc(O)cc3=O)oc2-c2ccc(O)cc2)[C@H](O)[C@H](OC(=O)N2CCOCC2)[C@H]1OC(=O)N1CCOCC1 InChI=1S/C31H34N2O14/c1-16-25(46-30(39)32-6-10-41-11-7-32)28(47-31(40)33-8-12-42-13-9-33)24(38)29(43-16)45-27-23(37)22-20(36)14-19(35)15-21(22)44-26(27)17-2-4-18(34)5-3-17/h2-5,14-16,24-25,28-29,34-35,37-38H,6-13H2,1H3/t16-,24+,25-,28-,29-/m0/s1 JOACWIZCYWXTEP-APXYOUHJSA-N 50381084 CHEMBL2017523 Ribosomal protein S6 kinase alpha-3 Homo sapiens 1430 ChEMBL 10.1016/j.bmcl.2012.03.033 10.7270/Q2QN67S5 22464132 Hilinski, MK; Mrozowski, RM; Clark, DE; Lannigan, DA University of Virginia http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50381084 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50381084&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 70695908 160860167 CHEMBL2017523 ZINC84619074 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50920067 CCN(Cc1cc(Nc2nc(C)cn3c(cnc23)-c2cn[nH]c2)sn1)C(C)(C)CO InChI=1S/C20H26N8OS/c1-5-27(20(3,4)12-29)11-15-6-17(30-26-15)25-18-19-21-9-16(14-7-22-23-8-14)28(19)10-13(2)24-18/h6-10,29H,5,11-12H2,1-4H3,(H,22,23)(H,24,25) RHGZQGXELRMGES-UHFFFAOYSA-N 50329198 2-(ethyl((5-(6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-ylamino)isothiazol-3-yl)methyl)amino)-2-methylpropan-1-ol::2-{ethyl[(5-{[6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]amino}isothiazol-3-yl)methyl]amino}-2-methylpropan-1-ol::CHEMBL1232515::CHEMBL1650533 Ribosomal protein S6 kinase alpha-3 Homo sapiens >100 ChEMBL 10.1021/jm1010995 10.7270/Q2VM4D76 21128646 Kerekes, AD; Esposite, SJ; Tagat, JR; Xiao, Y; Terracina, GA Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50329198 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50329198&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search EML 3MYG 25144732 123108313 CHEMBL1232515CHEMBL1650533 ZINC58660958 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50920102 Cc1cn2c(cnc2c(Nc2cc(CN3CCC(F)(F)C3)ns2)n1)-c1cn[nH]c1 InChI=1S/C18H18F2N8S/c1-11-8-28-14(12-5-22-23-6-12)7-21-17(28)16(24-11)25-15-4-13(26-29-15)9-27-3-2-18(19,20)10-27/h4-8H,2-3,9-10H2,1H3,(H,22,23)(H,24,25) JVAFTPDILUBIGR-UHFFFAOYSA-N 50335188 CHEMBL1650545::CHEMBL1650551::N-[3-[(3,3-Difluoro-1-pyrrolidinyl)methyl]-5-isothiazolyl]-6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-amine Hydrochloride Ribosomal protein S6 kinase alpha-3 Homo sapiens >100 ChEMBL 10.1021/jm1010995 10.7270/Q2VM4D76 21128646 Kerekes, AD; Esposite, SJ; Tagat, JR; Xiao, Y; Terracina, GA Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50335188 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50335188&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 25145145 125085290 CHEMBL1650545CHEMBL1650551 ZINC66101759 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50927265 CSc1ccccc1Nc1nc(nc2c(NCC3CC3)ncnc12)N1CCNCC1 InChI=1S/C21H26N8S/c1-30-16-5-3-2-4-15(16)26-20-17-18(19(25-13-24-17)23-12-14-6-7-14)27-21(28-20)29-10-8-22-9-11-29/h2-5,13-14,22H,6-12H2,1H3,(H,23,24,25)(H,26,27,28) HFLMLZKGLUEWBU-UHFFFAOYSA-N 50380246 CHEMBL2017214 Ribosomal protein S6 kinase alpha-3 Homo sapiens >40000 ChEMBL 10.1021/ml200070g 10.7270/Q2NZ88N1 24900346 Maryanoff, BE; McComsey, DF; Yabut, SC; Luci, DK; Jordan, AD; Masucci, JA; Jones, WJ; Abad, MC; Gibbs, AC; Petrounia, I TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50380246 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50380246&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search XNB 3Q92 53348216 160859329 CHEMBL2017214 ZINC72316202 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50931209 Cc1cn2c(cnc2c(Nc2cc(CN3CCCCC3)ns2)n1)-c1cn[nH]c1 InChI=1S/C19H22N8S/c1-13-11-27-16(14-8-21-22-9-14)10-20-19(27)18(23-13)24-17-7-15(25-28-17)12-26-5-3-2-4-6-26/h7-11H,2-6,12H2,1H3,(H,21,22)(H,23,24) SKDSRJRRAQLUPP-UHFFFAOYSA-N 50335179 6-Methyl-N-[3-(1-piperidinylmethyl)-5-isothiazolyl]-3-(1Hpyrazol-4-yl)imidazo[1,2-a]pyrazin-8-amine Hydrochloride::CHEMBL1650536::CHEMBL1739550 Ribosomal protein S6 kinase alpha-3 Homo sapiens 360 ChEMBL 10.1016/j.bmcl.2012.03.051 10.7270/Q2X34ZGD 22503250 Voss, ME; Rainka, MP; Fleming, M; Peterson, LH; Belanger, DB; Siddiqui, MA; Hruza, A; Voigt, J; Gray, K; Basso, AD AMRI http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50335179 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50335179&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 25144294 125085281 CHEMBL1739550CHEMBL1650536 ZINC66100059 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50931212 CC1CCCN(Cc2cc(Nc3nc(C)cn4c(cnc34)-c3cnn(CC(=O)NCc4cccs4)c3)sn2)C1 InChI=1S/C27H31N9OS2/c1-18-5-3-7-34(13-18)16-21-9-25(39-33-21)32-26-27-29-12-23(36(27)14-19(2)31-26)20-10-30-35(15-20)17-24(37)28-11-22-6-4-8-38-22/h4,6,8-10,12,14-15,18H,3,5,7,11,13,16-17H2,1-2H3,(H,28,37)(H,31,32) IMRNKQWAMWWEKR-UHFFFAOYSA-N 50381995 CHEMBL2022369 Ribosomal protein S6 kinase alpha-3 Homo sapiens 7700 ChEMBL 10.1016/j.bmcl.2012.03.051 10.7270/Q2X34ZGD 22503250 Voss, ME; Rainka, MP; Fleming, M; Peterson, LH; Belanger, DB; Siddiqui, MA; Hruza, A; Voigt, J; Gray, K; Basso, AD AMRI http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50381995 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50381995&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 59503744 160861078 CHEMBL2022369 ZINC84632705 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50931216 Cc1cn2c(cnc2c(Nc2cc(CN3CCCCC3)ns2)n1)-c1cnn(CC(=O)Nc2cccc(F)c2F)c1 InChI=1S/C27H27F2N9OS/c1-17-13-38-22(18-11-31-37(14-18)16-23(39)33-21-7-5-6-20(28)25(21)29)12-30-27(38)26(32-17)34-24-10-19(35-40-24)15-36-8-3-2-4-9-36/h5-7,10-14H,2-4,8-9,15-16H2,1H3,(H,32,34)(H,33,39) OPFNFKIYQOOQMS-UHFFFAOYSA-N 50381996 CHEMBL2022373 Ribosomal protein S6 kinase alpha-3 Homo sapiens 4300 ChEMBL 10.1016/j.bmcl.2012.03.051 10.7270/Q2X34ZGD 22503250 Voss, ME; Rainka, MP; Fleming, M; Peterson, LH; Belanger, DB; Siddiqui, MA; Hruza, A; Voigt, J; Gray, K; Basso, AD AMRI http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50381996 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50381996&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 59503711 160861079 CHEMBL2022373 ZINC84632793 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50931217 CC1CCCN(Cc2cc(Nc3nc(C)cn4c(cnc34)-c3cnn(CC(=O)Nc4ccncc4)c3)sn2)C1 InChI=1S/C27H30N10OS/c1-18-4-3-9-35(13-18)16-22-10-25(39-34-22)33-26-27-29-12-23(37(27)14-19(2)31-26)20-11-30-36(15-20)17-24(38)32-21-5-7-28-8-6-21/h5-8,10-12,14-15,18H,3-4,9,13,16-17H2,1-2H3,(H,31,33)(H,28,32,38) RIQJIFBZCJKJLX-UHFFFAOYSA-N 50381997 CHEMBL2022379 Ribosomal protein S6 kinase alpha-3 Homo sapiens 1100 ChEMBL 10.1016/j.bmcl.2012.03.051 10.7270/Q2X34ZGD 22503250 Voss, ME; Rainka, MP; Fleming, M; Peterson, LH; Belanger, DB; Siddiqui, MA; Hruza, A; Voigt, J; Gray, K; Basso, AD AMRI http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50381997 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50381997&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 44178069 160861080 CHEMBL2022379 ZINC84615927 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50931218 CC1CCCN(Cc2cc(Nc3nc(C)cn4c(cnc34)-c3cnn(CC(=O)Nc4ccncc4F)c3)sn2)C1 InChI=1S/C27H29FN10OS/c1-17-4-3-7-36(12-17)15-20-8-25(40-35-20)34-26-27-30-11-23(38(27)13-18(2)32-26)19-9-31-37(14-19)16-24(39)33-22-5-6-29-10-21(22)28/h5-6,8-11,13-14,17H,3-4,7,12,15-16H2,1-2H3,(H,32,34)(H,29,33,39) PBHYAPKEUOBQSL-UHFFFAOYSA-N 50381998 CHEMBL2022711 Ribosomal protein S6 kinase alpha-3 Homo sapiens 6800 ChEMBL 10.1016/j.bmcl.2012.03.051 10.7270/Q2X34ZGD 22503250 Voss, ME; Rainka, MP; Fleming, M; Peterson, LH; Belanger, DB; Siddiqui, MA; Hruza, A; Voigt, J; Gray, K; Basso, AD AMRI http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50381998 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50381998&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 59503659 160861081 CHEMBL2022711 ZINC84632858 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50925691 CCc1[nH]nc2ncnc(N3CCN(CC3)c3cc(Cl)cc(NCCN(C)C)c3C)c12 InChI=1S/C22H31ClN8/c1-5-17-20-21(28-27-17)25-14-26-22(20)31-10-8-30(9-11-31)19-13-16(23)12-18(15(19)2)24-6-7-29(3)4/h12-14,24H,5-11H2,1-4H3,(H,25,26,27,28) ACXREQVXILYMKB-UHFFFAOYSA-N 50379530 CHEMBL2012701 Ribosomal protein S6 kinase alpha-3 Homo sapiens 68 ChEMBL 10.1016/j.bmcl.2012.01.105 10.7270/Q2R49RSN 22342124 Bussenius, J; Anand, NK; Blazey, CM; Bowles, OJ; Bannen, LC; Chan, DS; Chen, B; Co, EW; Costanzo, S; DeFina, SC; Dubenko, L; Engst, S; Franzini, M; Huang, P; Jammalamadaka, V; Khoury, RG; Kim, MH; Klein, RR; Laird, D; Le, DT; Mac, MB; Matthews, DJ; Markby, D; Miller, N; Nuss, JM; Parks, JJ; Tsang, TH; Tsuhako, AL; Wang, Y; Xu, W; Rice, KD Exelixis Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50379530 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50379530&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 57345536 160858613 CHEMBL2012701 ZINC84603660 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50925692 CN(C)CCNc1cc(Cl)cc(N2CCN(CC2)c2ncnc3n[nH]c(Br)c23)c1C InChI=1S/C20H26BrClN8/c1-13-15(23-4-5-28(2)3)10-14(22)11-16(13)29-6-8-30(9-7-29)20-17-18(21)26-27-19(17)24-12-25-20/h10-12,23H,4-9H2,1-3H3,(H,24,25,26,27) GPNUVUGMFDKAJH-UHFFFAOYSA-N 50379531 CHEMBL2012702 Ribosomal protein S6 kinase alpha-3 Homo sapiens 248 ChEMBL 10.1016/j.bmcl.2012.01.105 10.7270/Q2R49RSN 22342124 Bussenius, J; Anand, NK; Blazey, CM; Bowles, OJ; Bannen, LC; Chan, DS; Chen, B; Co, EW; Costanzo, S; DeFina, SC; Dubenko, L; Engst, S; Franzini, M; Huang, P; Jammalamadaka, V; Khoury, RG; Kim, MH; Klein, RR; Laird, D; Le, DT; Mac, MB; Matthews, DJ; Markby, D; Miller, N; Nuss, JM; Parks, JJ; Tsang, TH; Tsuhako, AL; Wang, Y; Xu, W; Rice, KD Exelixis Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50379531 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50379531&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 67162253 160858614 CHEMBL2012702 ZINC13987191 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50925693 CN(C)CCNc1cc(Cl)cc(N2CCN(CC2)c2ncnc3n[nH]c(c23)C(F)(F)F)c1C InChI=1S/C21H26ClF3N8/c1-13-15(26-4-5-31(2)3)10-14(22)11-16(13)32-6-8-33(9-7-32)20-17-18(21(23,24)25)29-30-19(17)27-12-28-20/h10-12,26H,4-9H2,1-3H3,(H,27,28,29,30) BTHYNSZFAHGSOX-UHFFFAOYSA-N 50379532 CHEMBL2012703 Ribosomal protein S6 kinase alpha-3 Homo sapiens 24 ChEMBL 10.1016/j.bmcl.2012.01.105 10.7270/Q2R49RSN 22342124 Bussenius, J; Anand, NK; Blazey, CM; Bowles, OJ; Bannen, LC; Chan, DS; Chen, B; Co, EW; Costanzo, S; DeFina, SC; Dubenko, L; Engst, S; Franzini, M; Huang, P; Jammalamadaka, V; Khoury, RG; Kim, MH; Klein, RR; Laird, D; Le, DT; Mac, MB; Matthews, DJ; Markby, D; Miller, N; Nuss, JM; Parks, JJ; Tsang, TH; Tsuhako, AL; Wang, Y; Xu, W; Rice, KD Exelixis Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50379532 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50379532&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 67161715 160858615 CHEMBL2012703 ZINC84603671 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50948575 COc1c(Nc2ncc(Cl)c(N[C@@H]3[C@@H]4C[C@@H](C=C4)[C@@H]3C(N)=O)n2)ccc2CC[C@@H](CCc12)N1CCOCC1 InChI=1S/C28H35ClN6O3/c1-37-25-20-8-7-19(35-10-12-38-13-11-35)6-4-16(20)5-9-22(25)32-28-31-15-21(29)27(34-28)33-24-18-3-2-17(14-18)23(24)26(30)36/h2-3,5,9,15,17-19,23-24H,4,6-8,10-14H2,1H3,(H2,30,36)(H2,31,32,33,34)/t17-,18+,19+,23+,24-/m1/s1 LAJAFFLJAJMYLK-CVOKMOJFSA-N 50389154 CHEMBL2064666 Ribosomal protein S6 kinase alpha-3 Homo sapiens 13 ChEMBL 10.1021/jm201550q 10.7270/Q23F4QQN 22564207 Gingrich, DE; Lisko, JG; Curry, MA; Cheng, M; Quail, M; Lu, L; Wan, W; Albom, MS; Angeles, TS; Aimone, LD; Haltiwanger, RC; Wells-Knecht, K; Ott, GR; Ghose, AK; Ator, MA; Ruggeri, B; Dorsey, BD Cephalon Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50389154 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50389154&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 57325421 160868237 CHEMBL2064666 ZINC84654307 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50978455 CC(C)(C)NS(=O)(=O)c1cncc(c1)-c1ccn2nc(N)nc2c1 InChI=1S/C15H18N6O2S/c1-15(2,3)20-24(22,23)12-6-11(8-17-9-12)10-4-5-21-13(7-10)18-14(16)19-21/h4-9,20H,1-3H3,(H2,16,19) IVYWKCAOPCHVMX-UHFFFAOYSA-N 50401152 CHEMBL2205766 Ribosomal protein S6 kinase alpha-3 Homo sapiens <10000 ChEMBL 10.1016/j.bmcl.2012.05.090 10.7270/Q2HQ412B 22726925 Sunose, M; Bell, K; Ellard, K; Bergamini, G; Neubauer, G; Werner, T; Ramsden, N Cellzome Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50401152 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50401152&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 44557921 163350176 CHEMBL2205766 ZINC95562659 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50982985 Cc1ccc(cc1)-c1c(\C=C(/C#N)C(=O)NC(C)(C)C)n(CCCO)c2ncnc(N)c12 InChI=1S/C24H28N6O2/c1-15-6-8-16(9-7-15)19-18(12-17(13-25)23(32)29-24(2,3)4)30(10-5-11-31)22-20(19)21(26)27-14-28-22/h6-9,12,14,31H,5,10-11H2,1-4H3,(H,29,32)(H2,26,27,28)/b17-12+ SVXJIKFFHBDTNV-SFQUDFHCSA-N 50403059 CHEMBL2216829::US9505766, 64 Ribosomal protein S6 kinase alpha-3 Homo sapiens 4 ChEMBL 10.1021/jm3003203 10.7270/Q2X92CGP 22621397 Barf, T; Kaptein, A Covalution Pharma BV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50403059 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50403059&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 52939498 163352083 CHEMBL2216829 ZINC95564455 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50982986 Cc1ccc(cc1)-c1c(C(=O)CF)n(CCCO)c2ncnc(N)c12 InChI=1S/C18H19FN4O2/c1-11-3-5-12(6-4-11)14-15-17(20)21-10-22-18(15)23(7-2-8-24)16(14)13(25)9-19/h3-6,10,24H,2,7-9H2,1H3,(H2,20,21,22) IKLGYJACVCXYIL-UHFFFAOYSA-N 50248765 1-(4-amino-7-(3-hydroxypropyl)-5-p-tolyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl)-2-fluoroethanone::CHEMBL515414 Ribosomal protein S6 kinase alpha-3 Homo sapiens 15 ChEMBL 10.1021/jm3003203 10.7270/Q2X92CGP 22621397 Barf, T; Kaptein, A Covalution Pharma BV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50248765 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50248765&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 644243 104103317 CHEMBL515414 ZINC06718642 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50980793 CC(C)(C)Nc1c(Nc2ccnc(Nc3ccc(cc3)-c3ccncc3)n2)c(=O)c1=O InChI=1S/C23H22N6O2/c1-23(2,3)29-19-18(20(30)21(19)31)27-17-10-13-25-22(28-17)26-16-6-4-14(5-7-16)15-8-11-24-12-9-15/h4-13,29H,1-3H3,(H2,25,26,27,28) NDIUYMHNCUTVGE-UHFFFAOYSA-N 50402020 CHEMBL2205426 Ribosomal protein S6 kinase alpha-3 Homo sapiens 630 ChEMBL 10.1016/j.bmcl.2012.10.009 10.7270/Q2XK8GQ3 23103095 Zhang, Q; Xia, Z; Mitten, MJ; Lasko, LM; Klinghofer, V; Bouska, J; Johnson, EF; Penning, TD; Luo, Y; Giranda, VL; Shoemaker, AR; Stewart, KD; Djuric, SW; Vasudevan, A Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50402020 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50402020&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 71455860 163351044 CHEMBL2205426 ZINC95563476 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 51054109 Cc1c(F)c(ccc1C(=O)N1CCOc2ccc(cc2C1)-c1ccc(N)nc1)S(C)(=O)=O InChI=1S/C23H22FN3O4S/c1-14-18(5-7-20(22(14)24)32(2,29)30)23(28)27-9-10-31-19-6-3-15(11-17(19)13-27)16-4-8-21(25)26-12-16/h3-8,11-12H,9-10,13H2,1-2H3,(H2,25,26) LNFBAYSBVQBKFR-UHFFFAOYSA-N 50429867 CHEMBL2333365 Ribosomal protein S6 kinase alpha-3 Homo sapiens >10000 ChEMBL 10.1021/jm3007933 10.7270/Q2ZC847X 23394126 Takeuchi, CS; Kim, BG; Blazey, CM; Ma, S; Johnson, HW; Anand, NK; Arcalas, A; Baik, TG; Buhr, CA; Cannoy, J; Epshteyn, S; Joshi, A; Lara, K; Lee, MS; Wang, L; Leahy, JW; Nuss, JM; Aay, N; Aoyama, R; Foster, P; Lee, J; Lehoux, I; Munagala, N; Plonowski, A; Rajan, S; Woolfrey, J; Yamaguchi, K; Lamb, P; Miller, N Exelixis Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50429867 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50429867&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 59604787 164158742 CHEMBL2333365 ZINC95550928 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 51044719 CCC[C@@H]1O[C@@H](Oc2c(O)c3c(cc(O)cc3=O)oc2-c2ccc(O)cc2)[C@H](OC(C)=O)[C@H](OC(C)=O)[C@H]1OC(C)=O InChI=1S/C29H30O13/c1-5-6-20-25(37-13(2)30)27(38-14(3)31)28(39-15(4)32)29(41-20)42-26-23(36)22-19(35)11-18(34)12-21(22)40-24(26)16-7-9-17(33)10-8-16/h7-12,20,25,27-29,33-34,36H,5-6H2,1-4H3/t20-,25-,27+,28+,29-/m0/s1 KAPRRBPRIRLPMT-UDKWMEDXSA-N 50426388 CHEMBL2326709 Ribosomal protein S6 kinase alpha-3 Homo sapiens 1770 ChEMBL 10.1021/ml300298v 10.7270/Q2668FHP 23519677 Mrozowski, RM; Vemula, R; Wu, B; Zhang, Q; Schroeder, BR; Hilinski, MK; Clark, DE; Hecht, SM; O'Doherty, GA; Lannigan, DA Vanderbilt University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50426388 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50426388&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 51029811 164155263 CHEMBL2326709 ZINC95582838 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 51044720 CCC[C@@H]1O[C@@H](Oc2c(O)c3c(cc(O)cc3=O)oc2-c2ccc(O)cc2)[C@H](O)[C@H](OC(C)=O)[C@H]1OC(C)=O InChI=1S/C27H28O12/c1-4-5-18-24(35-12(2)28)26(36-13(3)29)22(34)27(38-18)39-25-21(33)20-17(32)10-16(31)11-19(20)37-23(25)14-6-8-15(30)9-7-14/h6-11,18,22,24,26-27,30-31,33-34H,4-5H2,1-3H3/t18-,22+,24-,26-,27-/m0/s1 BWGPUSCWLCQDLW-ODHHTFEASA-N 50426389 CHEMBL2321925 Ribosomal protein S6 kinase alpha-3 Homo sapiens 20 ChEMBL 10.1021/ml300298v 10.7270/Q2668FHP 23519677 Mrozowski, RM; Vemula, R; Wu, B; Zhang, Q; Schroeder, BR; Hilinski, MK; Clark, DE; Hecht, SM; O'Doherty, GA; Lannigan, DA Vanderbilt University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50426389 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50426389&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 71718779 164155264 CHEMBL2321925 ZINC95582689 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 51044721 CCC[C@@H]1O[C@@H](Oc2c(O)c3c(cc(O)cc3=O)oc2-c2ccc(O)cc2)[C@H](OC(C)=O)[C@H](O)[C@H]1OC(C)=O InChI=1S/C27H28O12/c1-4-5-18-24(35-12(2)28)22(34)26(36-13(3)29)27(38-18)39-25-21(33)20-17(32)10-16(31)11-19(20)37-23(25)14-6-8-15(30)9-7-14/h6-11,18,22,24,26-27,30-31,33-34H,4-5H2,1-3H3/t18-,22+,24-,26+,27-/m0/s1 FFMIBOVFDQKJAB-WGXSRGGHSA-N 50426390 CHEMBL2326708 Ribosomal protein S6 kinase alpha-3 Homo sapiens 620 ChEMBL 10.1021/ml300298v 10.7270/Q2668FHP 23519677 Mrozowski, RM; Vemula, R; Wu, B; Zhang, Q; Schroeder, BR; Hilinski, MK; Clark, DE; Hecht, SM; O'Doherty, GA; Lannigan, DA Vanderbilt University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50426390 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50426390&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 51029721 164155265 CHEMBL2326708 ZINC95580944 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 51044722 CCC[C@@H]1O[C@@H](Oc2c(O)c3c(cc(O)cc3=O)oc2-c2ccc(O)cc2)[C@H](O)[C@H](O)[C@H]1OC(C)=O InChI=1S/C25H26O11/c1-3-4-16-23(33-11(2)26)20(31)21(32)25(35-16)36-24-19(30)18-15(29)9-14(28)10-17(18)34-22(24)12-5-7-13(27)8-6-12/h5-10,16,20-21,23,25,27-28,30-32H,3-4H2,1-2H3/t16-,20-,21+,23-,25-/m0/s1 ZMYMDOYMCRIDDU-JRQRPHQWSA-N 50426391 CHEMBL2326707 Ribosomal protein S6 kinase alpha-3 Homo sapiens 1500 ChEMBL 10.1021/ml300298v 10.7270/Q2668FHP 23519677 Mrozowski, RM; Vemula, R; Wu, B; Zhang, Q; Schroeder, BR; Hilinski, MK; Clark, DE; Hecht, SM; O'Doherty, GA; Lannigan, DA Vanderbilt University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50426391 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50426391&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 51029813 164155266 CHEMBL2326707 ZINC95583844 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 51044723 CC(C)C[C@@H]1O[C@@H](Oc2c(O)c3c(cc(O)cc3=O)oc2-c2ccc(O)cc2)[C@H](O)[C@H](O)[C@H]1O InChI=1S/C24H26O10/c1-10(2)7-16-18(28)20(30)21(31)24(33-16)34-23-19(29)17-14(27)8-13(26)9-15(17)32-22(23)11-3-5-12(25)6-4-11/h3-6,8-10,16,18,20-21,24-26,28-31H,7H2,1-2H3/t16-,18-,20+,21+,24-/m0/s1 ZLGXMBZYVFJXKC-IMLMFSNGSA-N 50426392 CHEMBL2326706 Ribosomal protein S6 kinase alpha-3 Homo sapiens 480 ChEMBL 10.1021/ml300298v 10.7270/Q2668FHP 23519677 Mrozowski, RM; Vemula, R; Wu, B; Zhang, Q; Schroeder, BR; Hilinski, MK; Clark, DE; Hecht, SM; O'Doherty, GA; Lannigan, DA Vanderbilt University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50426392 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50426392&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 71527473 164155267 CHEMBL2326706 ZINC95584057 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 51044724 CCC[C@@H]1O[C@@H](Oc2c(O)c3c(cc(O)cc3=O)oc2-c2ccc(O)cc2)[C@H](O)[C@H](O)[C@H]1O InChI=1S/C23H24O10/c1-2-3-14-17(27)19(29)20(30)23(32-14)33-22-18(28)16-13(26)8-12(25)9-15(16)31-21(22)10-4-6-11(24)7-5-10/h4-9,14,17,19-20,23-25,27-30H,2-3H2,1H3/t14-,17-,19+,20+,23-/m0/s1 UJMSEHKTAOQMQX-QXKHQJIESA-N 50426393 CHEMBL2326705 Ribosomal protein S6 kinase alpha-3 Homo sapiens 710 ChEMBL 10.1021/ml300298v 10.7270/Q2668FHP 23519677 Mrozowski, RM; Vemula, R; Wu, B; Zhang, Q; Schroeder, BR; Hilinski, MK; Clark, DE; Hecht, SM; O'Doherty, GA; Lannigan, DA Vanderbilt University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50426393 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50426393&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 51029723 164155268 CHEMBL2326705 ZINC95583957 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 51044725 CC[C@@H]1O[C@@H](Oc2c(O)c3c(cc(O)cc3=O)oc2-c2ccc(O)cc2)[C@H](O)[C@H](O)[C@H]1O InChI=1S/C22H22O10/c1-2-13-16(26)18(28)19(29)22(31-13)32-21-17(27)15-12(25)7-11(24)8-14(15)30-20(21)9-3-5-10(23)6-4-9/h3-8,13,16,18-19,22-24,26-29H,2H2,1H3/t13-,16-,18+,19+,22-/m0/s1 JFVSCJCXPNSAIP-JPJNWVEQSA-N 50426394 CHEMBL2326704 Ribosomal protein S6 kinase alpha-3 Homo sapiens 1510 ChEMBL 10.1021/ml300298v 10.7270/Q2668FHP 23519677 Mrozowski, RM; Vemula, R; Wu, B; Zhang, Q; Schroeder, BR; Hilinski, MK; Clark, DE; Hecht, SM; O'Doherty, GA; Lannigan, DA Vanderbilt University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50426394 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50426394&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 71527472 164155269 CHEMBL2326704 ZINC95582393 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 51044726 C[C@@H]1O[C@@H](Oc2c(O)c3c(cc(O)cc3=O)oc2-c2ccc(O)cc2)[C@H](O)[C@H](OC(C)=O)[C@H]1OC(C)=O InChI=1S/C25H24O12/c1-10-21(34-11(2)26)24(35-12(3)27)20(32)25(33-10)37-23-19(31)18-16(30)8-15(29)9-17(18)36-22(23)13-4-6-14(28)7-5-13/h4-10,20-21,24-25,28-29,31-32H,1-3H3/t10-,20+,21-,24-,25-/m0/s1 POZDUGKSCAGWQI-IGKKHSBFSA-N 50241294 CHEMBL240954::SL-0101::kaempferol 3-O-(3'',4''-di-O-acetyl-alpha-L-rhamnopyranoside::kaempferol-3-O-(3,4-di-O-acetyl-alpha-L-rhamnopyranoside) Ribosomal protein S6 kinase alpha-3 Homo sapiens 990 ChEMBL 10.1021/ml300298v 10.7270/Q2668FHP 23519677 Mrozowski, RM; Vemula, R; Wu, B; Zhang, Q; Schroeder, BR; Hilinski, MK; Clark, DE; Hecht, SM; O'Doherty, GA; Lannigan, DA Vanderbilt University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50241294 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50241294&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 10459196 104098696 CHEMBL240954 ZINC28875874 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 51028774 CCN1CCC(CC1)Nc1ccc2NC(=O)C(=C(c3ncc[nH]3)c3ccc(Cl)cc3)c2c1 InChI=1S/C25H26ClN5O/c1-2-31-13-9-18(10-14-31)29-19-7-8-21-20(15-19)23(25(32)30-21)22(24-27-11-12-28-24)16-3-5-17(26)6-4-16/h3-8,11-12,15,18,29H,2,9-10,13-14H2,1H3,(H,27,28)(H,30,32) XHCPCYVQXFHJAU-UHFFFAOYSA-N 50420996 CHEMBL2086760 Ribosomal protein S6 kinase alpha-3 Homo sapiens 3 ChEMBL 10.1016/j.bmcl.2012.06.029 10.7270/Q2XG9SD4 22765894 Kim, MH; Tsuhako, AL; Co, EW; Aftab, DT; Bentzien, F; Chen, J; Cheng, W; Engst, S; Goon, L; Klein, RR; Le, DT; Mac, M; Parks, JJ; Qian, F; Rodriquez, M; Stout, TJ; Till, JH; Won, KA; Wu, X; Yakes, FM; Yu, P; Zhang, W; Zhao, Y; Lamb, P; Nuss, JM; Xu, W Exelixis Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50420996 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50420996&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 67161540 163370020 CHEMBL2086760 ZINC84742458 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 51062583 COc1ccc2CN(C(=O)c2c1)c1nc(cs1)C(=O)Nc1cnccc1N1CCNCC1 InChI=1S/C22H22N6O3S/c1-31-15-3-2-14-12-28(21(30)16(14)10-15)22-26-18(13-32-22)20(29)25-17-11-24-5-4-19(17)27-8-6-23-7-9-27/h2-5,10-11,13,23H,6-9,12H2,1H3,(H,25,29) KLJVDMAOKMSBQX-UHFFFAOYSA-N 50433476 CHEMBL2381116 Ribosomal protein S6 kinase alpha-3 Homo sapiens 1300 ChEMBL 10.1016/j.bmcl.2013.02.108 10.7270/Q2125V19 23535330 Huang, X; Cheng, CC; Fischmann, TO; Duca, JS; Richards, M; Tadikonda, PK; Reddy, PA; Zhao, L; Siddiqui, MA; Parry, D; Davis, N; Seghezzi, W; Wiswell, D; Shipps, GW Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50433476 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50433476&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 1AM 4HYH 24951610 175445793 CHEMBL2381116 ZINC95921334 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50547302 CC1(C)C(=O)N([C@H]2CCc3c2cccc3O)c2nc(Nc3ccccc3)ncc12 InChI=1S/C23H22N4O2/c1-23(2)17-13-24-22(25-14-7-4-3-5-8-14)26-20(17)27(21(23)29)18-12-11-16-15(18)9-6-10-19(16)28/h3-10,13,18,28H,11-12H2,1-2H3,(H,24,25,26)/t18-/m0/s1 XLFNLJYGUOLEJS-SFHVURJKSA-N 50208911 CHEMBL3884319 Ribosomal protein S6 kinase alpha-3 Homo sapiens 692 ChEMBL 10.1016/j.bmcl.2016.08.068 10.7270/Q2N018JC 27816515 Katz, JD; Haidle, A; Childers, KK; Zabierek, AA; Jewell, JP; Hou, Y; Altman, MD; Szewczak, A; Chen, D; Harsch, A; Hayashi, M; Warren, L; Hutton, M; Nuthall, H; Su, HP; Munshi, S; Stanton, MG; Davies, IW; Munoz, B; Northrup, A Merck & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50208911 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50208911&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 69036886 375982220 CHEMBL3884319 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 490731 CN(C)CC(NC(=O)N1Cc2nc(Nc3ccccc3)ncc2C1(C)C)c1ccccc1 InChI=1S/C25H30N6O/c1-25(2)20-15-26-23(27-19-13-9-6-10-14-19)28-22(20)17-31(25)24(32)29-21(16-30(3)4)18-11-7-5-8-12-18/h5-15,21H,16-17H2,1-4H3,(H,29,32)(H,26,27,28) QDIMOURDMVMOHZ-UHFFFAOYSA-N 244209 (s)-n-(2-(dimethylamino)-1-phenylethyl)-5,5-dimethyl-2-(phenylamino)-5h-pyrrolo[3,4-d]pyrimidine-6(7h)-carboxamide::US9546173, cmpd 148::US9546173, cmpd 168 Ribosomal protein S6 kinase alpha-3 Homo sapiens 96.0 US Patent 10.7270/Q2GT5Q52 US9546173 Dillon, MP; Lindvall, M; Poon, D; Ramurthy, S; Rauniyar, V; Shafer, C; Subramanian, S; Tanner, HR Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244209 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244209&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 122636136 376221932 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 490732 CN(C)CC(NC(=O)N1Cc2nc(Nc3ccccc3)ncc2C1(C)C)c1ccccc1 InChI=1S/C25H30N6O/c1-25(2)20-15-26-23(27-19-13-9-6-10-14-19)28-22(20)17-31(25)24(32)29-21(16-30(3)4)18-11-7-5-8-12-18/h5-15,21H,16-17H2,1-4H3,(H,29,32)(H,26,27,28) QDIMOURDMVMOHZ-UHFFFAOYSA-N 244209 (s)-n-(2-(dimethylamino)-1-phenylethyl)-5,5-dimethyl-2-(phenylamino)-5h-pyrrolo[3,4-d]pyrimidine-6(7h)-carboxamide::US9546173, cmpd 148::US9546173, cmpd 168 Ribosomal protein S6 kinase alpha-3 Homo sapiens 86.0 US Patent 10.7270/Q2GT5Q52 US9546173 Dillon, MP; Lindvall, M; Poon, D; Ramurthy, S; Rauniyar, V; Shafer, C; Subramanian, S; Tanner, HR Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244209 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244209&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 122636136 376221932 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 490733 CN(C)CC(NC(=O)N1Cc2nc(Nc3ccccc3)ncc2C1(C)C)c1ccccc1 InChI=1S/C25H30N6O/c1-25(2)20-15-26-23(27-19-13-9-6-10-14-19)28-22(20)17-31(25)24(32)29-21(16-30(3)4)18-11-7-5-8-12-18/h5-15,21H,16-17H2,1-4H3,(H,29,32)(H,26,27,28) QDIMOURDMVMOHZ-UHFFFAOYSA-N 244209 (s)-n-(2-(dimethylamino)-1-phenylethyl)-5,5-dimethyl-2-(phenylamino)-5h-pyrrolo[3,4-d]pyrimidine-6(7h)-carboxamide::US9546173, cmpd 148::US9546173, cmpd 168 Ribosomal protein S6 kinase alpha-3 Homo sapiens 461 US Patent 10.7270/Q2GT5Q52 US9546173 Dillon, MP; Lindvall, M; Poon, D; Ramurthy, S; Rauniyar, V; Shafer, C; Subramanian, S; Tanner, HR Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244209 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244209&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 122636136 376221932 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 490734 CN(C)CC(NC(=O)N1Cc2nc(Nc3ccccc3)ncc2C1(C)C)c1ccccc1 InChI=1S/C25H30N6O/c1-25(2)20-15-26-23(27-19-13-9-6-10-14-19)28-22(20)17-31(25)24(32)29-21(16-30(3)4)18-11-7-5-8-12-18/h5-15,21H,16-17H2,1-4H3,(H,29,32)(H,26,27,28) QDIMOURDMVMOHZ-UHFFFAOYSA-N 244209 (s)-n-(2-(dimethylamino)-1-phenylethyl)-5,5-dimethyl-2-(phenylamino)-5h-pyrrolo[3,4-d]pyrimidine-6(7h)-carboxamide::US9546173, cmpd 148::US9546173, cmpd 168 Ribosomal protein S6 kinase alpha-3 Homo sapiens 112 US Patent 10.7270/Q2GT5Q52 US9546173 Dillon, MP; Lindvall, M; Poon, D; Ramurthy, S; Rauniyar, V; Shafer, C; Subramanian, S; Tanner, HR Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244209 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244209&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 122636136 376221932 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 490735 CN1CCN(CC1(C)C)C(=O)N1Cc2nc(Nc3ccccc3)ncc2C1(C)C InChI=1S/C22H30N6O/c1-21(2)15-27(12-11-26(21)5)20(29)28-14-18-17(22(28,3)4)13-23-19(25-18)24-16-9-7-6-8-10-16/h6-10,13H,11-12,14-15H2,1-5H3,(H,23,24,25) BKDJDBPDISZFBJ-UHFFFAOYSA-N 244210 (5,5-dimethyl-2-(phenylamino)-5h-pyrrolo[3,4-d]pyrimidin-6(7h)-yl)(3,3,4-trimethylpiperazin-1-yl)methanone::US9546173, cmpd 149 Ribosomal protein S6 kinase alpha-3 Homo sapiens 611 US Patent 10.7270/Q2GT5Q52 US9546173 Dillon, MP; Lindvall, M; Poon, D; Ramurthy, S; Rauniyar, V; Shafer, C; Subramanian, S; Tanner, HR Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244210 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244210&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 118404612 376221933 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 490737 CC(CN(C)C)NC(=O)N1Cc2nc(Nc3ccccc3)ncc2C1(C)C InChI=1S/C20H28N6O/c1-14(12-25(4)5)22-19(27)26-13-17-16(20(26,2)3)11-21-18(24-17)23-15-9-7-6-8-10-15/h6-11,14H,12-13H2,1-5H3,(H,22,27)(H,21,23,24) HWTKDUIKACSTLX-UHFFFAOYSA-N 244211 (r)-n-(1-(dimethylamino)propan-2-yl)-5,5-dimethyl-2-(phenylamino)-5h-pyrrolo[3,4-d]pyrimidine-6(7h)-carboxamide::US9546173, cmpd 150::US9546173, cmpd 152::US9546173, cmpd 167 Ribosomal protein S6 kinase alpha-3 Homo sapiens 906 US Patent 10.7270/Q2GT5Q52 US9546173 Dillon, MP; Lindvall, M; Poon, D; Ramurthy, S; Rauniyar, V; Shafer, C; Subramanian, S; Tanner, HR Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244211 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244211&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 118404615 376221934 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 490739 CN1CCN(CC1)C(=O)N1Cc2nc(Nc3ccccc3)ncc2C1(C)C InChI=1S/C20H26N6O/c1-20(2)16-13-21-18(22-15-7-5-4-6-8-15)23-17(16)14-26(20)19(27)25-11-9-24(3)10-12-25/h4-8,13H,9-12,14H2,1-3H3,(H,21,22,23) FLSBFSZAHVORFU-UHFFFAOYSA-N 244212 (5,5-dimethyl-2-(phenylamino)-5h-pyrrolo[3,4-d]pyrimidin-6(7h)-yl)(4-methylpiperazin-1-yl)methanone::US9546173, cmpd 151 Ribosomal protein S6 kinase alpha-3 Homo sapiens 1170 US Patent 10.7270/Q2GT5Q52 US9546173 Dillon, MP; Lindvall, M; Poon, D; Ramurthy, S; Rauniyar, V; Shafer, C; Subramanian, S; Tanner, HR Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244212 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244212&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 118404614 376221935 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 490741 CC(CN(C)C)NC(=O)N1Cc2nc(Nc3ccccc3)ncc2C1(C)C InChI=1S/C20H28N6O/c1-14(12-25(4)5)22-19(27)26-13-17-16(20(26,2)3)11-21-18(24-17)23-15-9-7-6-8-10-15/h6-11,14H,12-13H2,1-5H3,(H,22,27)(H,21,23,24) HWTKDUIKACSTLX-UHFFFAOYSA-N 244211 (r)-n-(1-(dimethylamino)propan-2-yl)-5,5-dimethyl-2-(phenylamino)-5h-pyrrolo[3,4-d]pyrimidine-6(7h)-carboxamide::US9546173, cmpd 150::US9546173, cmpd 152::US9546173, cmpd 167 Ribosomal protein S6 kinase alpha-3 Homo sapiens 1360 US Patent 10.7270/Q2GT5Q52 US9546173 Dillon, MP; Lindvall, M; Poon, D; Ramurthy, S; Rauniyar, V; Shafer, C; Subramanian, S; Tanner, HR Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244211 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244211&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 118404615 376221934 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 490742 CN1CC(C1)NC(=O)N1Cc2nc(Nc3ccccc3)ncc2C1(C)C InChI=1S/C19H24N6O/c1-19(2)15-9-20-17(21-13-7-5-4-6-8-13)23-16(15)12-25(19)18(26)22-14-10-24(3)11-14/h4-9,14H,10-12H2,1-3H3,(H,22,26)(H,20,21,23) BYXHFKCDIPWWBC-UHFFFAOYSA-N 244214 5,5-dimethyl-n-(1-methylazetidin-3-yl)-2-(phenylamino)-5h-pyrrolo[3,4-d]pyrimidine-6(7h)-carboxamide::US9546173, cmpd 153 Ribosomal protein S6 kinase alpha-3 Homo sapiens 1370 US Patent 10.7270/Q2GT5Q52 US9546173 Dillon, MP; Lindvall, M; Poon, D; Ramurthy, S; Rauniyar, V; Shafer, C; Subramanian, S; Tanner, HR Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244214 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244214&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 118404616 376221936 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 490743 CN1CCN(C(Cc2ccccc2)C1)C(=O)N1Cc2nc(Nc3ccccc3)ncc2C1(C)C InChI=1S/C27H32N6O/c1-27(2)23-17-28-25(29-21-12-8-5-9-13-21)30-24(23)19-33(27)26(34)32-15-14-31(3)18-22(32)16-20-10-6-4-7-11-20/h4-13,17,22H,14-16,18-19H2,1-3H3,(H,28,29,30) BBXMKGRTPHWECA-UHFFFAOYSA-N 244215 (2-benzyl-4-methylpiperazin-1-yl)(5,5-dimethyl-2-(phenylamino)-5h-pyrrolo[3,4-d]pyrimidin-6(7h)-yl)methanone::US9546173, cmpd 154 Ribosomal protein S6 kinase alpha-3 Homo sapiens 1640 US Patent 10.7270/Q2GT5Q52 US9546173 Dillon, MP; Lindvall, M; Poon, D; Ramurthy, S; Rauniyar, V; Shafer, C; Subramanian, S; Tanner, HR Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244215 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244215&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 118404617 376221937 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 490744 CC1(C)N(Cc2nc(Nc3ccccc3)ncc12)C(=O)NC1CCN(Cc2ccccc2)C1 InChI=1S/C26H30N6O/c1-26(2)22-15-27-24(28-20-11-7-4-8-12-20)30-23(22)18-32(26)25(33)29-21-13-14-31(17-21)16-19-9-5-3-6-10-19/h3-12,15,21H,13-14,16-18H2,1-2H3,(H,29,33)(H,27,28,30) RAPBSGQZKKKEHS-UHFFFAOYSA-N 244216 US9546173, cmpd 155::n-(1-benzylpyrrolidin-3-yl)-5,5-dimethyl-2-(phenylamino)-5h-pyrrolo[3,4-d]pyrimidine-6(7h)-carboxamide Ribosomal protein S6 kinase alpha-3 Homo sapiens 1910 US Patent 10.7270/Q2GT5Q52 US9546173 Dillon, MP; Lindvall, M; Poon, D; Ramurthy, S; Rauniyar, V; Shafer, C; Subramanian, S; Tanner, HR Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244216 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244216&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 118409156 376221938 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 490746 CC(NC(=O)N1Cc2nc(Nc3ccccc3)ncc2C1(C)C)c1ccccc1 InChI=1S/C23H25N5O/c1-16(17-10-6-4-7-11-17)25-22(29)28-15-20-19(23(28,2)3)14-24-21(27-20)26-18-12-8-5-9-13-18/h4-14,16H,15H2,1-3H3,(H,25,29)(H,24,26,27) MEMAFGFDKNYDBP-UHFFFAOYSA-N 244217 (r)-5,5-dimethyl-2-(phenylamino)-n-(1-phenylethyl)-5h-pyrrolo[3,4-d]pyrimidine-6(7h)-carboxamide::US9546173, cmpd 156::US9546173, cmpd 169 Ribosomal protein S6 kinase alpha-3 Homo sapiens 2570 US Patent 10.7270/Q2GT5Q52 US9546173 Dillon, MP; Lindvall, M; Poon, D; Ramurthy, S; Rauniyar, V; Shafer, C; Subramanian, S; Tanner, HR Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244217 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244217&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 122636159 376221939 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 490747 CN(C)CCNC(=O)N1Cc2nc(Nc3ccccc3)ncc2C1(C)C InChI=1S/C19H26N6O/c1-19(2)15-12-21-17(22-14-8-6-5-7-9-14)23-16(15)13-25(19)18(26)20-10-11-24(3)4/h5-9,12H,10-11,13H2,1-4H3,(H,20,26)(H,21,22,23) LUDKWAUIQZCITP-UHFFFAOYSA-N 244218 US9546173, cmpd 157::n-(2-(dimethylamino)ethyl)-5,5-dimethyl-2-(phenylamino)-5h-pyrrolo[3,4-d]pyrimidine-6(7h)-carboxamide Ribosomal protein S6 kinase alpha-3 Homo sapiens 3850 US Patent 10.7270/Q2GT5Q52 US9546173 Dillon, MP; Lindvall, M; Poon, D; Ramurthy, S; Rauniyar, V; Shafer, C; Subramanian, S; Tanner, HR Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244218 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244218&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 118404620 376221940 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 490748 CN1CCC(C1)NC(=O)N1Cc2nc(Nc3ccccc3)ncc2C1(C)C InChI=1S/C20H26N6O/c1-20(2)16-11-21-18(22-14-7-5-4-6-8-14)24-17(16)13-26(20)19(27)23-15-9-10-25(3)12-15/h4-8,11,15H,9-10,12-13H2,1-3H3,(H,23,27)(H,21,22,24) NZPWOLHNMRKBMB-UHFFFAOYSA-N 244238 5,5-dimethyl-n-(1-methylpyrrolidin-3-yl)-2-(phenylamino)-5h-pyrrolo[3,4-d]pyrimidine-6(7h)-carboxamide::US9546173, cmpd 158 Ribosomal protein S6 kinase alpha-3 Homo sapiens 3880 US Patent 10.7270/Q2GT5Q52 US9546173 Dillon, MP; Lindvall, M; Poon, D; Ramurthy, S; Rauniyar, V; Shafer, C; Subramanian, S; Tanner, HR Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244238 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244238&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 118409157 376221941 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 490749 CC1(C)N(Cc2nc(Nc3ccccc3)ncc12)C(=O)NCC1CCN(Cc2ccccc2)C1 InChI=1S/C27H32N6O/c1-27(2)23-16-28-25(30-22-11-7-4-8-12-22)31-24(23)19-33(27)26(34)29-15-21-13-14-32(18-21)17-20-9-5-3-6-10-20/h3-12,16,21H,13-15,17-19H2,1-2H3,(H,29,34)(H,28,30,31) OAFLSSJHAZZTEW-UHFFFAOYSA-N 244239 US9546173, cmpd 159::n-((1-benzylpyrrolidin-3-yl)methyl)-5,5-dimethyl-2-(phenylamino)-5h-pyrrolo[3,4-d]pyrimidine-6(7h)-carboxamide Ribosomal protein S6 kinase alpha-3 Homo sapiens 5650 US Patent 10.7270/Q2GT5Q52 US9546173 Dillon, MP; Lindvall, M; Poon, D; Ramurthy, S; Rauniyar, V; Shafer, C; Subramanian, S; Tanner, HR Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244239 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244239&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 118404619 376221942 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 490750 Cn1cncc1CNC(=O)N1Cc2nc(Nc3ccccc3)ncc2C1(C)C InChI=1S/C20H23N7O/c1-20(2)16-11-22-18(24-14-7-5-4-6-8-14)25-17(16)12-27(20)19(28)23-10-15-9-21-13-26(15)3/h4-9,11,13H,10,12H2,1-3H3,(H,23,28)(H,22,24,25) SEHJTHYTPQTWOJ-UHFFFAOYSA-N 244240 5,5-dimethyl-n-((1-methyl-1h-imidazol-5-yl)methyl)-2-(phenylamino)-5h-pyrrolo[3,4-d]pyrimidine-6(7h)-carboxamide::US9546173, cmpd 160 Ribosomal protein S6 kinase alpha-3 Homo sapiens 5650 US Patent 10.7270/Q2GT5Q52 US9546173 Dillon, MP; Lindvall, M; Poon, D; Ramurthy, S; Rauniyar, V; Shafer, C; Subramanian, S; Tanner, HR Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244240 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244240&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 118404627 376221943 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 490751 CN(C)[C@@H]1CCCC[C@H]1NC(=O)N1Cc2nc(Nc3ccccc3)ncc2C1(C)C InChI=1S/C23H32N6O/c1-23(2)17-14-24-21(25-16-10-6-5-7-11-16)26-19(17)15-29(23)22(30)27-18-12-8-9-13-20(18)28(3)4/h5-7,10-11,14,18,20H,8-9,12-13,15H2,1-4H3,(H,27,30)(H,24,25,26)/t18-,20-/m1/s1 GGSXHTXJUORVAX-UYAOXDASSA-N 244241 US9546173, cmpd 161::n-((1r,2r)-2-(dimethylamino)cyclohexyl)-5,5-dimethyl-2-(phenylamino)-5h-pyrrolo[3,4-d]pyrimidine-6(7h)-carboxamide Ribosomal protein S6 kinase alpha-3 Homo sapiens 8200 US Patent 10.7270/Q2GT5Q52 US9546173 Dillon, MP; Lindvall, M; Poon, D; Ramurthy, S; Rauniyar, V; Shafer, C; Subramanian, S; Tanner, HR Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244241 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244241&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 118404621 376221944 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 490752 CC1(C)N(Cc2nc(Nc3ccccc3)ncc12)C(=O)NCc1cocn1 InChI=1S/C19H20N6O2/c1-19(2)15-9-20-17(23-13-6-4-3-5-7-13)24-16(15)10-25(19)18(26)21-8-14-11-27-12-22-14/h3-7,9,11-12H,8,10H2,1-2H3,(H,21,26)(H,20,23,24) PUGSSBKEKJKQGE-UHFFFAOYSA-N 244242 5,5-dimethyl-n-(oxazol-4-ylmethyl)-2-(phenylamino)-5h-pyrrolo[3,4-d]pyrimidine-6(7h)-carboxamide::US9546173, cmpd 162 Ribosomal protein S6 kinase alpha-3 Homo sapiens 8210 US Patent 10.7270/Q2GT5Q52 US9546173 Dillon, MP; Lindvall, M; Poon, D; Ramurthy, S; Rauniyar, V; Shafer, C; Subramanian, S; Tanner, HR Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244242 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244242&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 118404624 376221945 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 490753 CN1CCC(CC1)NC(=O)N1Cc2nc(Nc3ccccc3)ncc2C1(C)C InChI=1S/C21H28N6O/c1-21(2)17-13-22-19(23-15-7-5-4-6-8-15)25-18(17)14-27(21)20(28)24-16-9-11-26(3)12-10-16/h4-8,13,16H,9-12,14H2,1-3H3,(H,24,28)(H,22,23,25) ZJEJELHYKBJLQB-UHFFFAOYSA-N 244243 5,5-dimethyl-n-(1-methylpiperidin-4-yl)-2-(phenylamino)-5h-pyrrolo[3,4-d]pyrimidine-6(7h)-carboxamide::US9546173, cmpd 163 Ribosomal protein S6 kinase alpha-3 Homo sapiens 13960 US Patent 10.7270/Q2GT5Q52 US9546173 Dillon, MP; Lindvall, M; Poon, D; Ramurthy, S; Rauniyar, V; Shafer, C; Subramanian, S; Tanner, HR Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244243 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244243&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 118404628 376221946 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 490754 CC1(C)N(Cc2nc(Nc3ccccc3)ncc12)C(=O)NCCO InChI=1S/C17H21N5O2/c1-17(2)13-10-19-15(20-12-6-4-3-5-7-12)21-14(13)11-22(17)16(24)18-8-9-23/h3-7,10,23H,8-9,11H2,1-2H3,(H,18,24)(H,19,20,21) FJOPVPPVUPLUMD-UHFFFAOYSA-N 244244 US9546173, cmpd 164::n-(2-hydroxyethyl)-5,5-dimethyl-2-(phenylamino)-5h-pyrrolo[3,4-d]pyrimidine-6(7h)-carboxamide Ribosomal protein S6 kinase alpha-3 Homo sapiens 13970 US Patent 10.7270/Q2GT5Q52 US9546173 Dillon, MP; Lindvall, M; Poon, D; Ramurthy, S; Rauniyar, V; Shafer, C; Subramanian, S; Tanner, HR Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244244 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244244&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 118404622 376221947 C04080 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 490755 CC1(C)N(Cc2nc(Nc3ccccc3)nc(C3CCOCC3)c12)C(N)=O InChI=1S/C20H25N5O2/c1-20(2)16-15(12-25(20)18(21)26)23-19(22-14-6-4-3-5-7-14)24-17(16)13-8-10-27-11-9-13/h3-7,13H,8-12H2,1-2H3,(H2,21,26)(H,22,23,24) KYJHTGSZHYYZDI-UHFFFAOYSA-N 244245 5,5-dimethyl-2-(phenylamino)-n-(tetrahydro-2h-pyran-4-yl)-5h-pyrrolo[3,4-d]pyrimidine-6(7h)-carboxamide::US9546173, cmpd 165 Ribosomal protein S6 kinase alpha-3 Homo sapiens 15190 US Patent 10.7270/Q2GT5Q52 US9546173 Dillon, MP; Lindvall, M; Poon, D; Ramurthy, S; Rauniyar, V; Shafer, C; Subramanian, S; Tanner, HR Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244245 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244245&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 134823054 376221948 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 490756 CN(C)Cc1ccccc1CNC(=O)N1Cc2nc(Nc3ccccc3)ncc2C1(C)C InChI=1S/C25H30N6O/c1-25(2)21-15-26-23(28-20-12-6-5-7-13-20)29-22(21)17-31(25)24(32)27-14-18-10-8-9-11-19(18)16-30(3)4/h5-13,15H,14,16-17H2,1-4H3,(H,27,32)(H,26,28,29) UGOGDZQMZZVPGL-UHFFFAOYSA-N 244246 US9546173, cmpd 166::n-(2-((dimethylamino)methyl)benzyl)-5,5-dimethyl-2-(phenylamino)-5h-pyrrolo[3,4-d]pyrimidine-6(7h)-carboxamide Ribosomal protein S6 kinase alpha-3 Homo sapiens 16270 US Patent 10.7270/Q2GT5Q52 US9546173 Dillon, MP; Lindvall, M; Poon, D; Ramurthy, S; Rauniyar, V; Shafer, C; Subramanian, S; Tanner, HR Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244246 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244246&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 118404625 376221949 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 490758 CC(CN(C)C)NC(=O)N1Cc2nc(Nc3ccccc3)ncc2C1(C)C InChI=1S/C20H28N6O/c1-14(12-25(4)5)22-19(27)26-13-17-16(20(26,2)3)11-21-18(24-17)23-15-9-7-6-8-10-15/h6-11,14H,12-13H2,1-5H3,(H,22,27)(H,21,23,24) HWTKDUIKACSTLX-UHFFFAOYSA-N 244211 (r)-n-(1-(dimethylamino)propan-2-yl)-5,5-dimethyl-2-(phenylamino)-5h-pyrrolo[3,4-d]pyrimidine-6(7h)-carboxamide::US9546173, cmpd 150::US9546173, cmpd 152::US9546173, cmpd 167 Ribosomal protein S6 kinase alpha-3 Homo sapiens 17520 US Patent 10.7270/Q2GT5Q52 US9546173 Dillon, MP; Lindvall, M; Poon, D; Ramurthy, S; Rauniyar, V; Shafer, C; Subramanian, S; Tanner, HR Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244211 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244211&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 118404615 376221934 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 490760 CN(C)CC(NC(=O)N1Cc2nc(Nc3ccccc3)ncc2C1(C)C)c1ccccc1 InChI=1S/C25H30N6O/c1-25(2)20-15-26-23(27-19-13-9-6-10-14-19)28-22(20)17-31(25)24(32)29-21(16-30(3)4)18-11-7-5-8-12-18/h5-15,21H,16-17H2,1-4H3,(H,29,32)(H,26,27,28) QDIMOURDMVMOHZ-UHFFFAOYSA-N 244209 (s)-n-(2-(dimethylamino)-1-phenylethyl)-5,5-dimethyl-2-(phenylamino)-5h-pyrrolo[3,4-d]pyrimidine-6(7h)-carboxamide::US9546173, cmpd 148::US9546173, cmpd 168 Ribosomal protein S6 kinase alpha-3 Homo sapiens 20200 US Patent 10.7270/Q2GT5Q52 US9546173 Dillon, MP; Lindvall, M; Poon, D; Ramurthy, S; Rauniyar, V; Shafer, C; Subramanian, S; Tanner, HR Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244209 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244209&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 122636136 376221932 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 490761 CC(NC(=O)N1Cc2nc(Nc3ccccc3)ncc2C1(C)C)c1ccccc1 InChI=1S/C23H25N5O/c1-16(17-10-6-4-7-11-17)25-22(29)28-15-20-19(23(28,2)3)14-24-21(27-20)26-18-12-8-5-9-13-18/h4-14,16H,15H2,1-3H3,(H,25,29)(H,24,26,27) MEMAFGFDKNYDBP-UHFFFAOYSA-N 244217 (r)-5,5-dimethyl-2-(phenylamino)-n-(1-phenylethyl)-5h-pyrrolo[3,4-d]pyrimidine-6(7h)-carboxamide::US9546173, cmpd 156::US9546173, cmpd 169 Ribosomal protein S6 kinase alpha-3 Homo sapiens >25000 US Patent 10.7270/Q2GT5Q52 US9546173 Dillon, MP; Lindvall, M; Poon, D; Ramurthy, S; Rauniyar, V; Shafer, C; Subramanian, S; Tanner, HR Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244217 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244217&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 122636159 376221939 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 544961 O=C(Nc1ccc2[nH]cc(CN3CCOCC3)c2c1)c1cnn(Cc2ccccc2)c1 InChI=1S/C24H25N5O2/c30-24(20-14-26-29(17-20)15-18-4-2-1-3-5-18)27-21-6-7-23-22(12-21)19(13-25-23)16-28-8-10-31-11-9-28/h1-7,12-14,17,25H,8-11,15-16H2,(H,27,30) LWVMKBOQPOUDJM-UHFFFAOYSA-N 286074 1-Benzyl-N-(3-(morpholinomethyl)-1H-indol-5-yl)-1H-pyrazole-4-carboxamide::US10081632, Compound 1::US10758530, Compound 1::US9771366, Compound 1 Ribosomal protein S6 kinase alpha-3 Homo sapiens >10000 US Patent 10.7270/Q2VT1V45 aid1795713 US10081632 Dunn, SE; Jayanthan, A; Nagireddy, JR; Annedi, S; Van Drie, JH; Daynard, TS; Huynh, M PHOENIX MOLECULAR DESIGNS http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=286074 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=286074&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 130338835 378169671 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 544962 O=C(Nc1ccc2c(CN3CCOCC3)c[nH]c2c1)c1cnn(Cc2ccccc2)c1 InChI=1S/C24H25N5O2/c30-24(20-14-26-29(17-20)15-18-4-2-1-3-5-18)27-21-6-7-22-19(13-25-23(22)12-21)16-28-8-10-31-11-9-28/h1-7,12-14,17,25H,8-11,15-16H2,(H,27,30) BJYVKRYYBIFMGY-UHFFFAOYSA-N 286075 1-Benzyl-N-(3-(morpholinomethyl)-1H-indol-6-yl)-1H-pyrazole-4-carboxamide::US10081632, Compound 2::US10758530, Compound 2::US9771366, Compound 2 Ribosomal protein S6 kinase alpha-3 Homo sapiens >10000 US Patent 10.7270/Q2VT1V45 aid1795713 US10081632 Dunn, SE; Jayanthan, A; Nagireddy, JR; Annedi, S; Van Drie, JH; Daynard, TS; Huynh, M PHOENIX MOLECULAR DESIGNS http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=286075 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=286075&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 130338809 378169672 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 544963 CN1CCN(Cc2c[nH]c3ccc(NC(=O)c4cnn(Cc5ccccc5)c4)cc23)CC1 InChI=1S/C25H28N6O/c1-29-9-11-30(12-10-29)17-20-14-26-24-8-7-22(13-23(20)24)28-25(32)21-15-27-31(18-21)16-19-5-3-2-4-6-19/h2-8,13-15,18,26H,9-12,16-17H2,1H3,(H,28,32) NOJHMLGDGWPYAT-UHFFFAOYSA-N 286076 1-Benzyl-N-(3-((4-methylpiperazin-1-yl)methyl)-1H-indol-5-yl)-1H-pyrazole-4-carboxamide::US10081632, Compound 3::US10758530, Compound 3::US9771366, Compound 3 Ribosomal protein S6 kinase alpha-3 Homo sapiens >10000 US Patent 10.7270/Q2VT1V45 aid1795713 US10081632 Dunn, SE; Jayanthan, A; Nagireddy, JR; Annedi, S; Van Drie, JH; Daynard, TS; Huynh, M PHOENIX MOLECULAR DESIGNS http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=286076 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=286076&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 130338829 378169673 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 544964 CN1CCN(Cc2c[nH]c3cc(NC(=O)c4cnn(Cc5ccccc5)c4)ccc23)CC1 InChI=1S/C25H28N6O/c1-29-9-11-30(12-10-29)17-20-14-26-24-13-22(7-8-23(20)24)28-25(32)21-15-27-31(18-21)16-19-5-3-2-4-6-19/h2-8,13-15,18,26H,9-12,16-17H2,1H3,(H,28,32) VSLDKPAIVWRXRV-UHFFFAOYSA-N 286077 1-Benzyl-N-(3-((4-methylpiperazin-1-yl)methyl)-1H-indol-6-yl)-1H-pyrazole-4-carboxamide::US10081632, Compound 4::US10758530, Compound 4::US9771366, Compound 4 Ribosomal protein S6 kinase alpha-3 Homo sapiens >10000 US Patent 10.7270/Q2VT1V45 aid1795713 US10081632 Dunn, SE; Jayanthan, A; Nagireddy, JR; Annedi, S; Van Drie, JH; Daynard, TS; Huynh, M PHOENIX MOLECULAR DESIGNS http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=286077 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=286077&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 130338799 378169674 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 544965 O=C(Nc1ccc2scc(CN3CCOCC3)c2c1)c1cnn(Cc2ccccc2)c1 InChI=1S/C24H24N4O2S/c29-24(19-13-25-28(16-19)14-18-4-2-1-3-5-18)26-21-6-7-23-22(12-21)20(17-31-23)15-27-8-10-30-11-9-27/h1-7,12-13,16-17H,8-11,14-15H2,(H,26,29) BPQSDGUTLGUBCN-UHFFFAOYSA-N 286078 1-Benzyl-N-(3-(morpholinomethyl)benzo[b]thiophen-5-yl)-1H-pyrazole-4-carboxamide::US10081632, Compound 5::US10758530, Compound 5::US9771366, Compound 5 Ribosomal protein S6 kinase alpha-3 Homo sapiens >10000 US Patent 10.7270/Q2VT1V45 aid1795713 US10081632 Dunn, SE; Jayanthan, A; Nagireddy, JR; Annedi, S; Van Drie, JH; Daynard, TS; Huynh, M PHOENIX MOLECULAR DESIGNS http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=286078 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=286078&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 130338812 378169675 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 544966 O=C(Nc1ccc2scc(CN3CCNCC3)c2c1)c1cnn(Cc2ccccc2)c1 InChI=1S/C29H33N5O3S/c1-29(2,3)37-28(36)33-13-11-32(12-14-33)18-23-20-38-26-10-9-24(15-25(23)26)31-27(35)22-16-30-34(19-22)17-21-7-5-4-6-8-21/h4-10,15-16,19-20H,11-14,17-18H2,1-3H3,(H,31,35) WLXGOKNDFZAICH-UHFFFAOYSA-N 286079 1-Benzyl-N-(3-(piperazin-1-ylmethyl)benzo[b]thiophen-5-yl)-1H-pyrazole-4-carboxamide::BDBM342157::US10081632, Compound 6::US10758530, Compound 6 Ribosomal protein S6 kinase alpha-3 Homo sapiens >10000 US Patent 10.7270/Q2VT1V45 aid1795713 US10081632 Dunn, SE; Jayanthan, A; Nagireddy, JR; Annedi, S; Van Drie, JH; Daynard, TS; Huynh, M PHOENIX MOLECULAR DESIGNS http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=286079 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=286079&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 130338815 378169676 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 544967 O=C(Nc1ccc2c(CN3CCOCC3)coc2c1)c1cnn(Cc2ccccc2)c1 InChI=1S/C24H24N4O3/c29-24(19-13-25-28(16-19)14-18-4-2-1-3-5-18)26-21-6-7-22-20(17-31-23(22)12-21)15-27-8-10-30-11-9-27/h1-7,12-13,16-17H,8-11,14-15H2,(H,26,29) UVXIXOUWNBMAMM-UHFFFAOYSA-N 286080 1-benzyl-N-(3-(morpholinomethyl)benzofuran-6-yl)-1H-pyrazole-4-carboxamide::US10081632, Compound 7::US10758530, Compound 7::US9771366, Compound 7 Ribosomal protein S6 kinase alpha-3 Homo sapiens >10000 US Patent 10.7270/Q2VT1V45 aid1795713 US10081632 Dunn, SE; Jayanthan, A; Nagireddy, JR; Annedi, S; Van Drie, JH; Daynard, TS; Huynh, M PHOENIX MOLECULAR DESIGNS http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=286080 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=286080&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 130338797 378169677 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 544968 O=C(Nc1ccc2occ(CN3CCOCC3)c2c1)c1cnn(Cc2ccccc2)c1 InChI=1S/C24H24N4O3/c29-24(19-13-25-28(16-19)14-18-4-2-1-3-5-18)26-21-6-7-23-22(12-21)20(17-31-23)15-27-8-10-30-11-9-27/h1-7,12-13,16-17H,8-11,14-15H2,(H,26,29) FCEFQRNGVCNQCP-UHFFFAOYSA-N 286081 1-benzyl-N-(3-(morpholinomethyl)benzofuran-5-yl)-1H-pyrazole-4-carboxamide::US10081632, Compound 8::US10758530, Compound 8::US9771366, Compound 8 Ribosomal protein S6 kinase alpha-3 Homo sapiens >10000 US Patent 10.7270/Q2VT1V45 aid1795713 US10081632 Dunn, SE; Jayanthan, A; Nagireddy, JR; Annedi, S; Van Drie, JH; Daynard, TS; Huynh, M PHOENIX MOLECULAR DESIGNS http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=286081 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=286081&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 130338814 378169678 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 544969 O=C(Nc1ccc2occ(CN3CCNCC3)c2c1)c1cnn(Cc2ccccc2)c1 InChI=1S/C29H33N5O4/c1-29(2,3)38-28(36)33-13-11-32(12-14-33)18-23-20-37-26-10-9-24(15-25(23)26)31-27(35)22-16-30-34(19-22)17-21-7-5-4-6-8-21/h4-10,15-16,19-20H,11-14,17-18H2,1-3H3,(H,31,35) BWWCLYPRYMVYIH-UHFFFAOYSA-N 286082 1-benzyl-N-(3-(piperazin-1-ylmethyl)benzofuran-5-yl)-1H-pyrazole-4-carboxamide::BDBM342160::US10081632, Compound 9::US10758530, Compound 9 Ribosomal protein S6 kinase alpha-3 Homo sapiens >10000 US Patent 10.7270/Q2VT1V45 aid1795713 US10081632 Dunn, SE; Jayanthan, A; Nagireddy, JR; Annedi, S; Van Drie, JH; Daynard, TS; Huynh, M PHOENIX MOLECULAR DESIGNS http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=286082 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=286082&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 130338836 378169679 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 544970 O=C(Nc1ccc2c(CN3CCNCC3)coc2c1)c1cnn(Cc2ccccc2)c1 InChI=1S/C29H33N5O4/c1-29(2,3)38-28(36)33-13-11-32(12-14-33)18-23-20-37-26-15-24(9-10-25(23)26)31-27(35)22-16-30-34(19-22)17-21-7-5-4-6-8-21/h4-10,15-16,19-20H,11-14,17-18H2,1-3H3,(H,31,35) GYFANGIFZZUOEK-UHFFFAOYSA-N 286083 1-benzyl-N-(3-(piperazin-1-ylmethyl)benzofuran-6-yl)-1H-pyrazole-4-carboxamide::US10081632, Compound 10::US10758530, Compound 10 Ribosomal protein S6 kinase alpha-3 Homo sapiens >1000 US Patent 10.7270/Q2VT1V45 aid1795713 US10081632 Dunn, SE; Jayanthan, A; Nagireddy, JR; Annedi, S; Van Drie, JH; Daynard, TS; Huynh, M PHOENIX MOLECULAR DESIGNS http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=286083 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=286083&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 130338801 378169680 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 544971 C[C@@H]1CNC(=O)c2cc3ccc(NC(=O)c4cnn(Cc5ccccc5)c4)cc3n12 InChI=1S/C18H23BrN2O4/c1-11(10-20-17(23)25-18(2,3)4)21-14-9-13(19)7-6-12(14)8-15(21)16(22)24-5/h6-9,11H,10H2,1-5H3,(H,20,23)/t11-/m1/s1 FJRMMCYDWPNSIQ-LLVKDONJSA-N 286084 (R)-1-benzyl-N-(4-methyl-1-oxo-1,2,3,4-tetrahydropyrazino[1,2-a]indol-7-yl)-1H-pyrazole-4-carboxamide::BDBM286088::US10081632, Compound 11::US10758530, Compound 11 Ribosomal protein S6 kinase alpha-3 Homo sapiens 1377000 US Patent 10.7270/Q2VT1V45 aid1795713 US10081632 Dunn, SE; Jayanthan, A; Nagireddy, JR; Annedi, S; Van Drie, JH; Daynard, TS; Huynh, M PHOENIX MOLECULAR DESIGNS http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=286084 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=286084&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 130338867 378169681 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 544972 O=C(Nc1ccc2cc3C(=O)NCCn3c2c1)c1cnn(Cc2ccccc2)c1 InChI=1S/C22H19N5O2/c28-21(17-12-24-26(14-17)13-15-4-2-1-3-5-15)25-18-7-6-16-10-20-22(29)23-8-9-27(20)19(16)11-18/h1-7,10-12,14H,8-9,13H2,(H,23,29)(H,25,28) MXJJVWSXWJYCPL-UHFFFAOYSA-N 286085 1-benzyl-N-(1-oxo-1,2,3,4-tetrahydropyrazino[1,2-a]indol-7-yl)-1H-pyrazole-4-carboxamide::US10081632, Compound 12::US10758530, Compound 12::US9771366, Compound 12 Ribosomal protein S6 kinase alpha-3 Homo sapiens >1000 US Patent 10.7270/Q2VT1V45 aid1795713 US10081632 Dunn, SE; Jayanthan, A; Nagireddy, JR; Annedi, S; Van Drie, JH; Daynard, TS; Huynh, M PHOENIX MOLECULAR DESIGNS http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=286085 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=286085&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 130338827 378169682 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 544973 CN1CCc2oc3ccc(NC(=O)c4cnn(Cc5ccccc5)c4)cc3c2C1 InChI=1S/C23H22N4O2/c1-26-10-9-22-20(15-26)19-11-18(7-8-21(19)29-22)25-23(28)17-12-24-27(14-17)13-16-5-3-2-4-6-16/h2-8,11-12,14H,9-10,13,15H2,1H3,(H,25,28) ANWSGBBYDPFGIE-UHFFFAOYSA-N 286086 1-benzyl-N-(2-methyl-1,2,3,4-tetrahydrobenzofuro[3,2-c]pyridin-8-yl)-1H-pyrazole-4-carboxamide::US10081632, Compound 13::US10758530, Compound 13::US9771366, Compound 13 Ribosomal protein S6 kinase alpha-3 Homo sapiens >1000 US Patent 10.7270/Q2VT1V45 aid1795713 US10081632 Dunn, SE; Jayanthan, A; Nagireddy, JR; Annedi, S; Van Drie, JH; Daynard, TS; Huynh, M PHOENIX MOLECULAR DESIGNS http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=286086 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=286086&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 130338826 378169683 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 544974 CN1CCc2[nH]c3ccc(NC(=O)c4cnn(Cc5ccccc5)c4)cc3c2C1 InChI=1S/C23H23N5O/c1-27-10-9-22-20(15-27)19-11-18(7-8-21(19)26-22)25-23(29)17-12-24-28(14-17)13-16-5-3-2-4-6-16/h2-8,11-12,14,26H,9-10,13,15H2,1H3,(H,25,29) WZIWKBNUBKMDPP-UHFFFAOYSA-N 286087 1-benzyl-N-(2-methyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indol-8-yl)-1H-pyrazole-4-carboxamide::US10081632, Compound 14::US10758530, Compound 14::US9771366, Compound 14 Ribosomal protein S6 kinase alpha-3 Homo sapiens >1000 US Patent 10.7270/Q2VT1V45 aid1795713 US10081632 Dunn, SE; Jayanthan, A; Nagireddy, JR; Annedi, S; Van Drie, JH; Daynard, TS; Huynh, M PHOENIX MOLECULAR DESIGNS http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=286087 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=286087&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 130338817 378169684 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 544975 C[C@@H]1CNC(=O)c2cc3ccc(NC(=O)c4cnn(Cc5ccccc5)c4)cc3n12 InChI=1S/C18H23BrN2O4/c1-11(10-20-17(23)25-18(2,3)4)21-14-9-13(19)7-6-12(14)8-15(21)16(22)24-5/h6-9,11H,10H2,1-5H3,(H,20,23)/t11-/m1/s1 FJRMMCYDWPNSIQ-LLVKDONJSA-N 286084 (R)-1-benzyl-N-(4-methyl-1-oxo-1,2,3,4-tetrahydropyrazino[1,2-a]indol-7-yl)-1H-pyrazole-4-carboxamide::BDBM286088::US10081632, Compound 11::US10758530, Compound 11 Ribosomal protein S6 kinase alpha-3 Homo sapiens 94000 US Patent 10.7270/Q2VT1V45 aid1795713 US10081632 Dunn, SE; Jayanthan, A; Nagireddy, JR; Annedi, S; Van Drie, JH; Daynard, TS; Huynh, M PHOENIX MOLECULAR DESIGNS http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=286084 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=286084&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 130338867 378169681 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 544976 C[C@@H]1CNC(=O)c2cc3ccc(nc3n12)C(=O)Nc1cnn(Cc2cccc(N)c2)c1 InChI=1S/C27H29N7O4/c1-16-12-28-25(36)22-11-18-8-9-21(32-23(18)34(16)22)24(35)30-20-13-29-33(15-20)14-17-6-5-7-19(10-17)31-26(37)38-27(2,3)4/h5-11,13,15-16H,12,14H2,1-4H3,(H,28,36)(H,30,35)(H,31,37)/t16-/m1/s1 GWVZRHQKTLFWMI-MRXNPFEDSA-N 286089 (R)¿N-(1-(3-aminobenzyl)-1H-pyrazol-4-yl)-9-methyl-6-oxo-6,7,8,9-tetrahydropyrido[3′,2′:4,5]pyrrolo[1,2-a]pyrazine-2-carboxamide::BDBM342167::US10081632, Compound 16::US10758530, Compound 16 Ribosomal protein S6 kinase alpha-3 Homo sapiens 23000 US Patent 10.7270/Q2VT1V45 aid1795713 US10081632 Dunn, SE; Jayanthan, A; Nagireddy, JR; Annedi, S; Van Drie, JH; Daynard, TS; Huynh, M PHOENIX MOLECULAR DESIGNS http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=286089 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=286089&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 130338805 378169686 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 544977 C[C@@H]1CNC(=O)c2cc3ccc(nc3n12)C(=O)Nc1cnn(Cc2ccccc2N)c1 InChI=1S/C27H29N7O4/c1-16-12-28-25(36)22-11-17-9-10-21(31-23(17)34(16)22)24(35)30-19-13-29-33(15-19)14-18-7-5-6-8-20(18)32-26(37)38-27(2,3)4/h5-11,13,15-16H,12,14H2,1-4H3,(H,28,36)(H,30,35)(H,32,37)/t16-/m1/s1 RTMXBFRXLJUUNI-MRXNPFEDSA-N 286090 (R)¿N-(1-(2-aminobenzyl)-1H-pyrazol-4-yl)-9-methyl-6-oxo-6,7,8,9-tetrahydropyrido[3′,2′:4,5]pyrrolo[1,2-a]pyrazine-2-carboxamide::BDBM342168::US10081632, Compound 17::US10758530, Compound 17 Ribosomal protein S6 kinase alpha-3 Homo sapiens 14000 US Patent 10.7270/Q2VT1V45 aid1795713 US10081632 Dunn, SE; Jayanthan, A; Nagireddy, JR; Annedi, S; Van Drie, JH; Daynard, TS; Huynh, M PHOENIX MOLECULAR DESIGNS http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=286090 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=286090&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 130338899 378169687 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 544978 C[C@@H]1CNC(=O)c2cc3ccc(nc3n12)C(=O)Nc1cnn(Cc2ccc(N)cc2)c1 InChI=1S/C27H29N7O4/c1-16-12-28-25(36)22-11-18-7-10-21(32-23(18)34(16)22)24(35)30-20-13-29-33(15-20)14-17-5-8-19(9-6-17)31-26(37)38-27(2,3)4/h5-11,13,15-16H,12,14H2,1-4H3,(H,28,36)(H,30,35)(H,31,37)/t16-/m1/s1 DPHPBJAORBZVTM-MRXNPFEDSA-N 286091 (R)¿N-(1-(4-aminobenzyl)-1H-pyrazol-4-yl)-9-methyl-6-oxo-6,7,8,9-tetrahydropyrido[3′,2′:4,5]pyrrolo[1,2-a]pyrazine-2-carboxamide::BDBM286094::US10081632, Compound 18::US10758530, Compound 18 Ribosomal protein S6 kinase alpha-3 Homo sapiens 12000 US Patent 10.7270/Q2VT1V45 aid1795713 US10081632 Dunn, SE; Jayanthan, A; Nagireddy, JR; Annedi, S; Van Drie, JH; Daynard, TS; Huynh, M PHOENIX MOLECULAR DESIGNS http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=286091 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=286091&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 130338820 378169688 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 544979 C[C@@H]1CNC(=O)c2cc3ccc(NC(=O)c4cnn(Cc5cccc(N)c5)c4)nc3n12 InChI=1S/C27H29N7O4/c1-16-12-28-25(36)21-11-18-8-9-22(31-23(18)34(16)21)32-24(35)19-13-29-33(15-19)14-17-6-5-7-20(10-17)30-26(37)38-27(2,3)4/h5-11,13,15-16H,12,14H2,1-4H3,(H,28,36)(H,30,37)(H,31,32,35)/t16-/m1/s1 ANPAIGHTTKYVNM-MRXNPFEDSA-N 286092 (R)-1-(3-aminobenzyl)-N-(9-methyl-6-oxo-6,7,8,9-tetrahydropyrido[3′,2′:4,5]pyrrolo[1,2-a]pyrazin-2-yl)-1H-pyrazole-4-carboxamide::BDBM342170::US10081632, Compound 19::US10758530, Compound 19 Ribosomal protein S6 kinase alpha-3 Homo sapiens 123000 US Patent 10.7270/Q2VT1V45 aid1795713 US10081632 Dunn, SE; Jayanthan, A; Nagireddy, JR; Annedi, S; Van Drie, JH; Daynard, TS; Huynh, M PHOENIX MOLECULAR DESIGNS http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=286092 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=286092&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 130338876 378169689 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 544980 C[C@@H]1CNC(=O)c2cc3ccc(nc3n12)C(=O)Nc1cnn(CC2CCN(C)CC2)c1 InChI=1S/C22H27N7O2/c1-14-10-23-22(31)19-9-16-3-4-18(26-20(16)29(14)19)21(30)25-17-11-24-28(13-17)12-15-5-7-27(2)8-6-15/h3-4,9,11,13-15H,5-8,10,12H2,1-2H3,(H,23,31)(H,25,30)/t14-/m1/s1 LLJNOVYIPCASQO-CQSZACIVSA-N 286093 (R)-9-methyl-N-(1-((1-methylpiperidin-4-yl)methyl)-1H-pyrazol-4-yl)-6-oxo-6,7,8,9-tetrahydropyrido[3′,2′:4,5]pyrrolo[1,2-a]pyrazine-2-carboxamide::US10081632, Compound 20::US10758530, Compound 20::US9771366, Compound 20 Ribosomal protein S6 kinase alpha-3 Homo sapiens 124000 US Patent 10.7270/Q2VT1V45 aid1795713 US10081632 Dunn, SE; Jayanthan, A; Nagireddy, JR; Annedi, S; Van Drie, JH; Daynard, TS; Huynh, M PHOENIX MOLECULAR DESIGNS http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=286093 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=286093&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 130338850 378169690 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 544981 C[C@@H]1CNC(=O)c2cc3ccc(nc3n12)C(=O)Nc1cnn(Cc2ccc(N)cc2)c1 InChI=1S/C27H29N7O4/c1-16-12-28-25(36)22-11-18-7-10-21(32-23(18)34(16)22)24(35)30-20-13-29-33(15-20)14-17-5-8-19(9-6-17)31-26(37)38-27(2,3)4/h5-11,13,15-16H,12,14H2,1-4H3,(H,28,36)(H,30,35)(H,31,37)/t16-/m1/s1 DPHPBJAORBZVTM-MRXNPFEDSA-N 286091 (R)¿N-(1-(4-aminobenzyl)-1H-pyrazol-4-yl)-9-methyl-6-oxo-6,7,8,9-tetrahydropyrido[3′,2′:4,5]pyrrolo[1,2-a]pyrazine-2-carboxamide::BDBM286094::US10081632, Compound 18::US10758530, Compound 18 Ribosomal protein S6 kinase alpha-3 Homo sapiens 18000 US Patent 10.7270/Q2VT1V45 aid1795713 US10081632 Dunn, SE; Jayanthan, A; Nagireddy, JR; Annedi, S; Van Drie, JH; Daynard, TS; Huynh, M PHOENIX MOLECULAR DESIGNS http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=286091 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=286091&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 130338820 378169688 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50727021 CC1(C)OCC(=O)Nc2cc(Nc3nc(NCC(F)(F)F)c4occc4n3)ccc12 InChI=1S/C19H18F3N5O3/c1-18(2)11-4-3-10(7-13(11)25-14(28)8-30-18)24-17-26-12-5-6-29-15(12)16(27-17)23-9-19(20,21)22/h3-7H,8-9H2,1-2H3,(H,25,28)(H2,23,24,26,27) IGRYEDIMNMEBBU-UHFFFAOYSA-N 50235816 CHEMBL4069365 Ribosomal protein S6 kinase alpha-3 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2016.09.077 10.7270/Q2WQ061V 27789138 Hoemann, M; Wilson, N; Argiriadi, M; Banach, D; Burchat, A; Calderwood, D; Clapham, B; Cox, P; Duignan, DB; Konopacki, D; Somal, G; Vasudevan, A AbbVie Bioresearch Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50235816 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50235816&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 137634241 384991558 CHEMBL4069365 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50727242 FC(F)(F)CNc1nc(Nc2ccc3cn[nH]c3c2)nc2ccoc12 InChI=1S/C15H11F3N6O/c16-15(17,18)7-19-13-12-10(3-4-25-12)22-14(23-13)21-9-2-1-8-6-20-24-11(8)5-9/h1-6H,7H2,(H,20,24)(H2,19,21,22,23) FMTZJHHPYOHWNQ-UHFFFAOYSA-N 50235820 CHEMBL4066664 Ribosomal protein S6 kinase alpha-3 Homo sapiens 9810 ChEMBL 10.1016/j.bmcl.2016.09.077 10.7270/Q2WQ061V 27789138 Hoemann, M; Wilson, N; Argiriadi, M; Banach, D; Burchat, A; Calderwood, D; Clapham, B; Cox, P; Duignan, DB; Konopacki, D; Somal, G; Vasudevan, A AbbVie Bioresearch Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50235820 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50235820&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 67129970 384991562 CHEMBL4066664 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50727770 FC(F)(F)CNc1nc(Nc2ccc(N3CCOCC3)c(Cl)c2)nc2ccoc12 InChI=1S/C18H17ClF3N5O2/c19-12-9-11(1-2-14(12)27-4-7-28-8-5-27)24-17-25-13-3-6-29-15(13)16(26-17)23-10-18(20,21)22/h1-3,6,9H,4-5,7-8,10H2,(H2,23,24,25,26) WHFIWINTCCNYQZ-UHFFFAOYSA-N 50235817 CHEMBL4078893 Ribosomal protein S6 kinase alpha-3 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2016.09.077 10.7270/Q2WQ061V 27789138 Hoemann, M; Wilson, N; Argiriadi, M; Banach, D; Burchat, A; Calderwood, D; Clapham, B; Cox, P; Duignan, DB; Konopacki, D; Somal, G; Vasudevan, A AbbVie Bioresearch Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50235817 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50235817&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 68755406 384991559 CHEMBL4078893 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50726741 CCCNC(=O)c1ccc(Nc2nc(NCC(F)(F)F)c3cc[nH]c3n2)cc1 InChI=1S/C18H19F3N6O/c1-2-8-23-16(28)11-3-5-12(6-4-11)25-17-26-14-13(7-9-22-14)15(27-17)24-10-18(19,20)21/h3-7,9H,2,8,10H2,1H3,(H,23,28)(H3,22,24,25,26,27) UJBJWYNPUOLFIZ-UHFFFAOYSA-N 50235830 CHEMBL2006765 Ribosomal protein S6 kinase alpha-3 Homo sapiens 83 ChEMBL 10.1016/j.bmcl.2016.09.077 10.7270/Q2WQ061V 27789138 Hoemann, M; Wilson, N; Argiriadi, M; Banach, D; Burchat, A; Calderwood, D; Clapham, B; Cox, P; Duignan, DB; Konopacki, D; Somal, G; Vasudevan, A AbbVie Bioresearch Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50235830 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50235830&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 16129448 384991572 CHEMBL2006765 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 675903 C[C@@H]1CNC(=O)c2cc3ccc(nc3n12)C(=O)Nc1cnn(Cc2ccc(N)cc2)c1 InChI=1S/C27H29N7O4/c1-16-12-28-25(36)22-11-18-7-10-21(32-23(18)34(16)22)24(35)30-20-13-29-33(15-20)14-17-5-8-19(9-6-17)31-26(37)38-27(2,3)4/h5-11,13,15-16H,12,14H2,1-4H3,(H,28,36)(H,30,35)(H,31,37)/t16-/m1/s1 DPHPBJAORBZVTM-MRXNPFEDSA-N 286091 (R)¿N-(1-(4-aminobenzyl)-1H-pyrazol-4-yl)-9-methyl-6-oxo-6,7,8,9-tetrahydropyrido[3′,2′:4,5]pyrrolo[1,2-a]pyrazine-2-carboxamide::BDBM286094::US10081632, Compound 18::US10758530, Compound 18 Ribosomal protein S6 kinase alpha-3 Homo sapiens 1.7 US Patent 10.7270/Q2862JK5 aid1797204 US9771366 Dunn, SE; Jayanthan, A; Nagireddy, JR; Annedi, S; Van Drie, JH; Daynard, TS; Huynh, M PHOENIX MOLECULAR DESIGN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=286091 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=286091&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 130338820 378169688 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 675906 C[C@@H]1CNC(=O)c2cc3cc(NC(=O)c4cnn(Cc5ccccc5)c4)ccc3n12 InChI=1S/C23H21N5O2/c1-15-11-24-23(30)21-10-17-9-19(7-8-20(17)28(15)21)26-22(29)18-12-25-27(14-18)13-16-5-3-2-4-6-16/h2-10,12,14-15H,11,13H2,1H3,(H,24,30)(H,26,29)/t15-/m1/s1 DWRUMXZDNGCUDK-OAHLLOKOSA-N 342166 (R)-1-benzyl-N-(9-methyl-6-oxo-6,7,8,9-tetrahydropyrido[3',2':4,5]pyrrolo[1,2-a]pyrazin-2-yl)-1H-pyrazole-4-carboxamide::US9771366, Compound 15 Ribosomal protein S6 kinase alpha-3 Homo sapiens 6.0 US Patent 10.7270/Q2862JK5 aid1797204 US9771366 Dunn, SE; Jayanthan, A; Nagireddy, JR; Annedi, S; Van Drie, JH; Daynard, TS; Huynh, M PHOENIX MOLECULAR DESIGN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=342166 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=342166&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 138805970 385212890 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50766601 Cc1ccc(cc1)-c1c(\C=C(/C#N)C(=O)OC(C)(C)C)n(CCCO)c2ncnc(N)c12 InChI=1S/C24H27N5O3/c1-15-6-8-16(9-7-15)19-18(12-17(13-25)23(31)32-24(2,3)4)29(10-5-11-30)22-20(19)21(26)27-14-28-22/h6-9,12,14,30H,5,10-11H2,1-4H3,(H2,26,27,28)/b17-12+ IEUOMYJAIZIKES-SFQUDFHCSA-N 259806 US9505766, CN-OtBu (5) Ribosomal protein S6 kinase alpha-3 Homo sapiens 7.0 ChEMBL 10.1021/acs.jmedchem.6b00788 10.7270/Q2JW8H9T 27996267 Jackson, PA; Widen, JC; Harki, DA; Brummond, KM University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259806 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259806&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 52938516 350084500 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50766602 Cc1ccc(cc1)-c1c(\C=C\C#N)n(CCCO)c2ncnc(N)c12 InChI=1S/C19H19N5O/c1-13-5-7-14(8-6-13)16-15(4-2-9-20)24(10-3-11-25)19-17(16)18(21)22-12-23-19/h2,4-8,12,25H,3,10-11H2,1H3,(H2,21,22,23)/b4-2+ LPADWFDQODOOMS-DUXPYHPUSA-N 259803 US9505766, acrylonitrile (3) Ribosomal protein S6 kinase alpha-3 Homo sapiens 750 ChEMBL 10.1021/acs.jmedchem.6b00788 10.7270/Q2JW8H9T 27996267 Jackson, PA; Widen, JC; Harki, DA; Brummond, KM University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259803 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259803&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 56840684 350084497 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50766605 COC(=O)\C=C\c1c(-c2ccc(C)cc2)c2c(N)ncnc2n1CCCO InChI=1S/C20H22N4O3/c1-13-4-6-14(7-5-13)17-15(8-9-16(26)27-2)24(10-3-11-25)20-18(17)19(21)22-12-23-20/h4-9,12,25H,3,10-11H2,1-2H3,(H2,21,22,23)/b9-8+ SUWNTOBZXIAHKB-CMDGGOBGSA-N 259804 US9505766, Me acrylate (2) Ribosomal protein S6 kinase alpha-3 Homo sapiens 250 ChEMBL 10.1021/acs.jmedchem.6b00788 10.7270/Q2JW8H9T 27996267 Jackson, PA; Widen, JC; Harki, DA; Brummond, KM University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259804 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259804&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 16662748 350084498 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50766620 CC(C)NC(=O)C(=C\c1c(-c2ccc(C)cc2)c2c(N)ncnc2n1CCCO)\C#N InChI=1S/C23H26N6O2/c1-14(2)28-23(31)17(12-24)11-18-19(16-7-5-15(3)6-8-16)20-21(25)26-13-27-22(20)29(18)9-4-10-30/h5-8,11,13-14,30H,4,9-10H2,1-3H3,(H,28,31)(H2,25,26,27)/b17-11+ POTINGKLYOETSI-GZTJUZNOSA-N 259808 US9505766, 74::US9505766, CN-NHiPr (7) Ribosomal protein S6 kinase alpha-3 Homo sapiens 5.0 ChEMBL 10.1021/acs.jmedchem.6b00788 10.7270/Q2JW8H9T 27996267 Jackson, PA; Widen, JC; Harki, DA; Brummond, KM University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259808 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259808&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 52938644 350084502 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 51123844 CCN(CCO)Cc1cc(Nc2nc(C)cn3c(cnc23)-c2cn[nH]c2)sn1 InChI=1S/C18H22N8OS/c1-3-25(4-5-27)11-14-6-16(28-24-14)23-17-18-19-9-15(13-7-20-21-8-13)26(18)10-12(2)22-17/h6-10,27H,3-5,11H2,1-2H3,(H,20,21)(H,22,23) RHAMYMXUVZEEJR-UHFFFAOYSA-N 50460767 CHEMBL4228240 Ribosomal protein S6 kinase alpha-3 Homo sapiens 180 ChEMBL 10.1016/j.bmcl.2018.02.037 10.7270/Q2K35X91 29545102 Yu, T; Zhang, Y; Kerekes, AD; Tagat, JR; Doll, RJ; Xiao, Y; Esposite, S; Hruza, A; Belanger, DB; Voss, M; Rainka, MP; Basso, A; Liu, M; Liang, L; Sui, N; Prelusky, D; Rindgen, D; Zhang, L Merck & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50460767 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50460767&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 145967951 433928032 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 51123979 Cc1cn2c(cnc2c(Nc2cc(Cc3ccccn3)ns2)n1)-c1cn[nH]c1 InChI=1S/C19H16N8S/c1-12-11-27-16(13-8-22-23-9-13)10-21-19(27)18(24-12)25-17-7-15(26-28-17)6-14-4-2-3-5-20-14/h2-5,7-11H,6H2,1H3,(H,22,23)(H,24,25) NNQHKTWARZSGTQ-UHFFFAOYSA-N 50460773 CHEMBL4227082 Ribosomal protein S6 kinase alpha-3 Homo sapiens 260 ChEMBL 10.1016/j.bmcl.2018.02.037 10.7270/Q2K35X91 29545102 Yu, T; Zhang, Y; Kerekes, AD; Tagat, JR; Doll, RJ; Xiao, Y; Esposite, S; Hruza, A; Belanger, DB; Voss, M; Rainka, MP; Basso, A; Liu, M; Liang, L; Sui, N; Prelusky, D; Rindgen, D; Zhang, L Merck & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50460773 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50460773&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 25145716 433928038 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 51099799 CN(C1COC1)C(C)(C)\C=C(/C#N)C(=O)N1CCC[C@H]1Cn1nc(-c2ccc(Oc3ccccc3)cc2F)c2c(N)ncnc12 InChI=1S/C33H35FN8O3/c1-33(2,40(3)23-18-44-19-23)15-21(16-35)32(43)41-13-7-8-22(41)17-42-31-28(30(36)37-20-38-31)29(39-42)26-12-11-25(14-27(26)34)45-24-9-5-4-6-10-24/h4-6,9-12,14-15,20,22-23H,7-8,13,17-19H2,1-3H3,(H2,36,37,38)/b21-15+/t22-/m0/s1 YELZMARZEBVKBL-VAZXNAHHSA-N 50369721 CHEMBL3702836 Ribosomal protein S6 kinase alpha-3 Homo sapiens 0.54 ChEMBL 10.1016/j.ejmech.2018.03.062 10.7270/Q2JS9SZ0 29631132 Liang, C; Tian, D; Ren, X; Ding, S; Jia, M; Xin, M; Thareja, S Shaanxi University of Science & Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50369721 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50369721&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 73389638 160848823 ZINC49020255 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 51130216 CS(=O)(=O)Nc1cccc(CC(=O)Nc2nc(cs2)-c2c[nH]c3ncccc23)c1 InChI=1S/C19H17N5O3S2/c1-29(26,27)24-13-5-2-4-12(8-13)9-17(25)23-19-22-16(11-28-19)15-10-21-18-14(15)6-3-7-20-18/h2-8,10-11,24H,9H2,1H3,(H,20,21)(H,22,23,25) HIUHVDROHDSKTC-UHFFFAOYSA-N 50463479 CHEMBL4249925 Ribosomal protein S6 kinase alpha-3 Homo sapiens >2000 ChEMBL 10.1016/j.bmcl.2018.06.040 10.7270/Q2ZC85HX 30082069 Bandarage, UK; Cao, J; Come, JH; Court, JJ; Gao, H; Jacobs, MD; Marhefka, C; Nanthakumar, S; Green, J Vertex Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50463479 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50463479&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 6U1 5KKS 11690457 433930744 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 51128225 O=C(Cc1cccc(OCCCN2CCNCC2)c1)Nc1nc(cs1)-c1ccncc1 InChI=1S/C23H27N5O2S/c29-22(27-23-26-21(17-31-23)19-5-7-24-8-6-19)16-18-3-1-4-20(15-18)30-14-2-11-28-12-9-25-10-13-28/h1,3-8,15,17,25H,2,9-14,16H2,(H,26,27,29) XLMFBNMLEHYJGT-UHFFFAOYSA-N 50462709 CHEMBL4245507 Ribosomal protein S6 kinase alpha-3 Homo sapiens >1000 ChEMBL 10.1016/j.bmcl.2018.06.043 10.7270/Q2XP77MH 29945794 Gao, H; Marhefka, C; Jacobs, MD; Cao, J; Bandarage, UK; Green, J Vertex Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50462709 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50462709&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 60097495 433929974 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 51130385 O=C(Cc1cccc(OCCCC2CCNCC2)c1)Nc1nc(cs1)-c1c[nH]c2ncccc12 InChI=1S/C26H29N5O2S/c32-24(31-26-30-23(17-34-26)22-16-29-25-21(22)7-2-10-28-25)15-19-4-1-6-20(14-19)33-13-3-5-18-8-11-27-12-9-18/h1-2,4,6-7,10,14,16-18,27H,3,5,8-9,11-13,15H2,(H,28,29)(H,30,31,32) OKUPZBPYLVKVSU-UHFFFAOYSA-N 50463483 CHEMBL4245242 Ribosomal protein S6 kinase alpha-3 Homo sapiens >2000 ChEMBL 10.1016/j.bmcl.2018.06.040 10.7270/Q2ZC85HX 30082069 Bandarage, UK; Cao, J; Come, JH; Court, JJ; Gao, H; Jacobs, MD; Marhefka, C; Nanthakumar, S; Green, J Vertex Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50463483 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50463483&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 504 5UZK 11561968 433930748 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 51139582 Oc1c(F)cc(cc1F)-c1cnccc1-c1ccc(cc1)N1CCOCC1 InChI=1S/C21H18F2N2O2/c22-19-11-15(12-20(23)21(19)26)18-13-24-6-5-17(18)14-1-3-16(4-2-14)25-7-9-27-10-8-25/h1-6,11-13,26H,7-10H2 YUYJEQHNWKQNBT-UHFFFAOYSA-N 50111384 CHEMBL3604794 Ribosomal protein S6 kinase alpha-3 Homo sapiens 210 ChEMBL 10.1016/j.bmcl.2018.08.020 10.7270/Q2F76G78 30170943 Jain, R; Mathur, M; Lan, J; Costales, A; Atallah, G; Ramurthy, S; Subramanian, S; Setti, L; Feucht, P; Warne, B; Doyle, L; Basham, S; Jefferson, AB; Appleton, BA; Lindvall, M; Shafer, CM Novartis Institutes for Biomedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50111384 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50111384&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 118704762 104005992 CHEMBL3604794 ZINC13440454 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 51139583 CN1CCN(CC1)c1ccc(cc1)-c1c(cnc2[nH]ccc12)-c1ccc(cc1)C(F)F InChI=1S/C25H24F2N4/c1-30-12-14-31(15-13-30)20-8-6-18(7-9-20)23-21-10-11-28-25(21)29-16-22(23)17-2-4-19(5-3-17)24(26)27/h2-11,16,24H,12-15H2,1H3,(H,28,29) QBMXUNLXQVIKBI-UHFFFAOYSA-N 50467095 CHEMBL4277304 Ribosomal protein S6 kinase alpha-3 Homo sapiens 800 ChEMBL 10.1016/j.bmcl.2018.08.020 10.7270/Q2F76G78 30170943 Jain, R; Mathur, M; Lan, J; Costales, A; Atallah, G; Ramurthy, S; Subramanian, S; Setti, L; Feucht, P; Warne, B; Doyle, L; Basham, S; Jefferson, AB; Appleton, BA; Lindvall, M; Shafer, CM Novartis Institutes for Biomedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50467095 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50467095&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 145984931 433934360 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 51139584 Oc1c(F)cc(cc1F)-c1cnc2[nH]ccc2c1-c1ccc(cc1)N1CCOCC1 InChI=1S/C23H19F2N3O2/c24-19-11-15(12-20(25)22(19)29)18-13-27-23-17(5-6-26-23)21(18)14-1-3-16(4-2-14)28-7-9-30-10-8-28/h1-6,11-13,29H,7-10H2,(H,26,27) VCHSVXNNDHWXHW-UHFFFAOYSA-N 50467096 CHEMBL4278817 Ribosomal protein S6 kinase alpha-3 Homo sapiens 2.0 ChEMBL 10.1016/j.bmcl.2018.08.020 10.7270/Q2F76G78 30170943 Jain, R; Mathur, M; Lan, J; Costales, A; Atallah, G; Ramurthy, S; Subramanian, S; Setti, L; Feucht, P; Warne, B; Doyle, L; Basham, S; Jefferson, AB; Appleton, BA; Lindvall, M; Shafer, CM Novartis Institutes for Biomedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50467096 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50467096&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 145980512 433934361 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 51139585 Oc1ccc(cc1)-c1cn[nH]c1-c1ccc(O)cc1 InChI=1S/C15H12N2O2/c18-12-5-1-10(2-6-12)14-9-16-17-15(14)11-3-7-13(19)8-4-11/h1-9,18-19H,(H,16,17) FHGTUVGVZRNUDB-UHFFFAOYSA-N 50111372 CHEMBL3604771 Ribosomal protein S6 kinase alpha-3 Homo sapiens 20 ChEMBL 10.1016/j.bmcl.2018.08.020 10.7270/Q2F76G78 30170943 Jain, R; Mathur, M; Lan, J; Costales, A; Atallah, G; Ramurthy, S; Subramanian, S; Setti, L; Feucht, P; Warne, B; Doyle, L; Basham, S; Jefferson, AB; Appleton, BA; Lindvall, M; Shafer, CM Novartis Institutes for Biomedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50111372 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50111372&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 91844463 104005980 CHEMBL3604771 ZINC13440462 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 51139588 CN1CCN(CC1)c1ccc(cc1)-c1c(cnc2[nH]ccc12)-c1ccc(F)cc1 InChI=1S/C24H23FN4/c1-28-12-14-29(15-13-28)20-8-4-18(5-9-20)23-21-10-11-26-24(21)27-16-22(23)17-2-6-19(25)7-3-17/h2-11,16H,12-15H2,1H3,(H,26,27) PXOJAKNEDGMEJP-UHFFFAOYSA-N 50467098 CHEMBL4285259 Ribosomal protein S6 kinase alpha-3 Homo sapiens >20000 ChEMBL 10.1016/j.bmcl.2018.08.020 10.7270/Q2F76G78 30170943 Jain, R; Mathur, M; Lan, J; Costales, A; Atallah, G; Ramurthy, S; Subramanian, S; Setti, L; Feucht, P; Warne, B; Doyle, L; Basham, S; Jefferson, AB; Appleton, BA; Lindvall, M; Shafer, CM Novartis Institutes for Biomedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50467098 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50467098&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 145993273 433934363 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 51139589 CN1CCN(CC1)c1ccc(cc1)-c1c(cnc2[nH]ccc12)-c1cc(F)cc(F)c1 InChI=1S/C24H22F2N4/c1-29-8-10-30(11-9-29)20-4-2-16(3-5-20)23-21-6-7-27-24(21)28-15-22(23)17-12-18(25)14-19(26)13-17/h2-7,12-15H,8-11H2,1H3,(H,27,28) KBGVUVVNCOYRNB-UHFFFAOYSA-N 50467099 CHEMBL4284142 Ribosomal protein S6 kinase alpha-3 Homo sapiens 6000 ChEMBL 10.1016/j.bmcl.2018.08.020 10.7270/Q2F76G78 30170943 Jain, R; Mathur, M; Lan, J; Costales, A; Atallah, G; Ramurthy, S; Subramanian, S; Setti, L; Feucht, P; Warne, B; Doyle, L; Basham, S; Jefferson, AB; Appleton, BA; Lindvall, M; Shafer, CM Novartis Institutes for Biomedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50467099 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50467099&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 145989941 433934364 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 51139590 COc1c(F)cc(cc1F)-c1cnc2[nH]ccc2c1-c1ccc(cc1)N1CCN(C)CC1 InChI=1S/C25H24F2N4O/c1-30-9-11-31(12-10-30)18-5-3-16(4-6-18)23-19-7-8-28-25(19)29-15-20(23)17-13-21(26)24(32-2)22(27)14-17/h3-8,13-15H,9-12H2,1-2H3,(H,28,29) LVTSEXYEBKDJBH-UHFFFAOYSA-N 50467100 CHEMBL4276872 Ribosomal protein S6 kinase alpha-3 Homo sapiens 500 ChEMBL 10.1016/j.bmcl.2018.08.020 10.7270/Q2F76G78 30170943 Jain, R; Mathur, M; Lan, J; Costales, A; Atallah, G; Ramurthy, S; Subramanian, S; Setti, L; Feucht, P; Warne, B; Doyle, L; Basham, S; Jefferson, AB; Appleton, BA; Lindvall, M; Shafer, CM Novartis Institutes for Biomedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50467100 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50467100&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 145984908 433934365 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 51139591 CN1CCN(CC1)c1ccc(cc1)-c1c(cnc2[nH]ccc12)-c1ccc(F)cc1 InChI=1S/C24H23FN4/c1-28-12-14-29(15-13-28)20-8-4-18(5-9-20)23-21-10-11-26-24(21)27-16-22(23)17-2-6-19(25)7-3-17/h2-11,16H,12-15H2,1H3,(H,26,27) PXOJAKNEDGMEJP-UHFFFAOYSA-N 50467098 CHEMBL4285259 Ribosomal protein S6 kinase alpha-3 Homo sapiens 1900 ChEMBL 10.1016/j.bmcl.2018.08.020 10.7270/Q2F76G78 30170943 Jain, R; Mathur, M; Lan, J; Costales, A; Atallah, G; Ramurthy, S; Subramanian, S; Setti, L; Feucht, P; Warne, B; Doyle, L; Basham, S; Jefferson, AB; Appleton, BA; Lindvall, M; Shafer, CM Novartis Institutes for Biomedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50467098 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50467098&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 145993273 433934363 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 51139592 CN1CCN(CC1)c1ccc(cc1)-c1c(cnc2[nH]ccc12)-c1cn[nH]c1 InChI=1S/C21H22N6/c1-26-8-10-27(11-9-26)17-4-2-15(3-5-17)20-18-6-7-22-21(18)23-14-19(20)16-12-24-25-13-16/h2-7,12-14H,8-11H2,1H3,(H,22,23)(H,24,25) GVBJNYJFQAEXCP-UHFFFAOYSA-N 50467101 CHEMBL4280695 Ribosomal protein S6 kinase alpha-3 Homo sapiens 2400 ChEMBL 10.1016/j.bmcl.2018.08.020 10.7270/Q2F76G78 30170943 Jain, R; Mathur, M; Lan, J; Costales, A; Atallah, G; Ramurthy, S; Subramanian, S; Setti, L; Feucht, P; Warne, B; Doyle, L; Basham, S; Jefferson, AB; Appleton, BA; Lindvall, M; Shafer, CM Novartis Institutes for Biomedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50467101 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50467101&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 145979228 433934366 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 51139593 CN1CCN(CC1)c1ccc(cc1)-c1c(cnc2[nH]ccc12)-c1cc(F)c(O)c(F)c1 InChI=1S/C24H22F2N4O/c1-29-8-10-30(11-9-29)17-4-2-15(3-5-17)22-18-6-7-27-24(18)28-14-19(22)16-12-20(25)23(31)21(26)13-16/h2-7,12-14,31H,8-11H2,1H3,(H,27,28) KJQYFARJBLRFQX-UHFFFAOYSA-N 50467097 CHEMBL4292020 Ribosomal protein S6 kinase alpha-3 Homo sapiens 54 ChEMBL 10.1016/j.bmcl.2018.08.020 10.7270/Q2F76G78 30170943 Jain, R; Mathur, M; Lan, J; Costales, A; Atallah, G; Ramurthy, S; Subramanian, S; Setti, L; Feucht, P; Warne, B; Doyle, L; Basham, S; Jefferson, AB; Appleton, BA; Lindvall, M; Shafer, CM Novartis Institutes for Biomedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50467097 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50467097&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 145986466 433934362 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 51139599 CN1CCN(CC1)c1ccc(cc1)-c1c(cnc2[nH]ccc12)-c1ccc(cc1)C(F)F InChI=1S/C25H24F2N4/c1-30-12-14-31(15-13-30)20-8-6-18(7-9-20)23-21-10-11-28-25(21)29-16-22(23)17-2-4-19(5-3-17)24(26)27/h2-11,16,24H,12-15H2,1H3,(H,28,29) QBMXUNLXQVIKBI-UHFFFAOYSA-N 50467095 CHEMBL4277304 Ribosomal protein S6 kinase alpha-3 Homo sapiens 18100 ChEMBL 10.1016/j.bmcl.2018.08.020 10.7270/Q2F76G78 30170943 Jain, R; Mathur, M; Lan, J; Costales, A; Atallah, G; Ramurthy, S; Subramanian, S; Setti, L; Feucht, P; Warne, B; Doyle, L; Basham, S; Jefferson, AB; Appleton, BA; Lindvall, M; Shafer, CM Novartis Institutes for Biomedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50467095 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50467095&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 145984931 433934360 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 51139600 CN1CCN(CC1)c1ccc(cc1)-c1c(cnc2[nH]ccc12)-c1ccnc(F)c1 InChI=1S/C23H22FN5/c1-28-10-12-29(13-11-28)18-4-2-16(3-5-18)22-19-7-9-26-23(19)27-15-20(22)17-6-8-25-21(24)14-17/h2-9,14-15H,10-13H2,1H3,(H,26,27) AJYZYCRPVRWXHJ-UHFFFAOYSA-N 50467102 CHEMBL4287512 Ribosomal protein S6 kinase alpha-3 Homo sapiens >20000 ChEMBL 10.1016/j.bmcl.2018.08.020 10.7270/Q2F76G78 30170943 Jain, R; Mathur, M; Lan, J; Costales, A; Atallah, G; Ramurthy, S; Subramanian, S; Setti, L; Feucht, P; Warne, B; Doyle, L; Basham, S; Jefferson, AB; Appleton, BA; Lindvall, M; Shafer, CM Novartis Institutes for Biomedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50467102 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50467102&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 145991585 433934367 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 51139601 COc1c(F)cc(cc1F)-c1cnc2[nH]ccc2c1-c1ccc(cc1)N1CCN(C)CC1 InChI=1S/C25H24F2N4O/c1-30-9-11-31(12-10-30)18-5-3-16(4-6-18)23-19-7-8-28-25(19)29-15-20(23)17-13-21(26)24(32-2)22(27)14-17/h3-8,13-15H,9-12H2,1-2H3,(H,28,29) LVTSEXYEBKDJBH-UHFFFAOYSA-N 50467100 CHEMBL4276872 Ribosomal protein S6 kinase alpha-3 Homo sapiens >20000 ChEMBL 10.1016/j.bmcl.2018.08.020 10.7270/Q2F76G78 30170943 Jain, R; Mathur, M; Lan, J; Costales, A; Atallah, G; Ramurthy, S; Subramanian, S; Setti, L; Feucht, P; Warne, B; Doyle, L; Basham, S; Jefferson, AB; Appleton, BA; Lindvall, M; Shafer, CM Novartis Institutes for Biomedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50467100 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50467100&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 145984908 433934365 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 51139602 Oc1c(F)cc(cc1F)-c1cnc2[nH]ccc2c1-c1ccc(cc1)N1CCOCC1 InChI=1S/C23H19F2N3O2/c24-19-11-15(12-20(25)22(19)29)18-13-27-23-17(5-6-26-23)21(18)14-1-3-16(4-2-14)28-7-9-30-10-8-28/h1-6,11-13,29H,7-10H2,(H,26,27) VCHSVXNNDHWXHW-UHFFFAOYSA-N 50467096 CHEMBL4278817 Ribosomal protein S6 kinase alpha-3 Homo sapiens 50 ChEMBL 10.1016/j.bmcl.2018.08.020 10.7270/Q2F76G78 30170943 Jain, R; Mathur, M; Lan, J; Costales, A; Atallah, G; Ramurthy, S; Subramanian, S; Setti, L; Feucht, P; Warne, B; Doyle, L; Basham, S; Jefferson, AB; Appleton, BA; Lindvall, M; Shafer, CM Novartis Institutes for Biomedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50467096 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50467096&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 145980512 433934361 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 51139603 Cc1ccc(cc1)-c1c(cnc2[nH]ccc12)-c1cc(F)c(O)c(F)c1 InChI=1S/C20H14F2N2O/c1-11-2-4-12(5-3-11)18-14-6-7-23-20(14)24-10-15(18)13-8-16(21)19(25)17(22)9-13/h2-10,25H,1H3,(H,23,24) MOMPHYXXCRRPRT-UHFFFAOYSA-N 50467103 CHEMBL4289492 Ribosomal protein S6 kinase alpha-3 Homo sapiens 232 ChEMBL 10.1016/j.bmcl.2018.08.020 10.7270/Q2F76G78 30170943 Jain, R; Mathur, M; Lan, J; Costales, A; Atallah, G; Ramurthy, S; Subramanian, S; Setti, L; Feucht, P; Warne, B; Doyle, L; Basham, S; Jefferson, AB; Appleton, BA; Lindvall, M; Shafer, CM Novartis Institutes for Biomedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50467103 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50467103&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 145986826 433934368 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 51139604 CN1CCN(CC1)c1ccc(cc1)-c1ccncc1-c1cc(F)c(O)c(F)c1 InChI=1S/C22H21F2N3O/c1-26-8-10-27(11-9-26)17-4-2-15(3-5-17)18-6-7-25-14-19(18)16-12-20(23)22(28)21(24)13-16/h2-7,12-14,28H,8-11H2,1H3 IKUFKDGKRLMXEX-UHFFFAOYSA-N 50111385 CHEMBL3604793 Ribosomal protein S6 kinase alpha-3 Homo sapiens 340 ChEMBL 10.1016/j.bmcl.2018.08.020 10.7270/Q2F76G78 30170943 Jain, R; Mathur, M; Lan, J; Costales, A; Atallah, G; Ramurthy, S; Subramanian, S; Setti, L; Feucht, P; Warne, B; Doyle, L; Basham, S; Jefferson, AB; Appleton, BA; Lindvall, M; Shafer, CM Novartis Institutes for Biomedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50111385 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50111385&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 2NK 4NUS 73010393 104005993 CHEMBL3604793 ZINC13440451 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 51139605 Oc1ccc(cc1)-c1cn[nH]c1-c1ccc(O)cc1 InChI=1S/C15H12N2O2/c18-12-5-1-10(2-6-12)14-9-16-17-15(14)11-3-7-13(19)8-4-11/h1-9,18-19H,(H,16,17) FHGTUVGVZRNUDB-UHFFFAOYSA-N 50111372 CHEMBL3604771 Ribosomal protein S6 kinase alpha-3 Homo sapiens 2800 ChEMBL 10.1016/j.bmcl.2018.08.020 10.7270/Q2F76G78 30170943 Jain, R; Mathur, M; Lan, J; Costales, A; Atallah, G; Ramurthy, S; Subramanian, S; Setti, L; Feucht, P; Warne, B; Doyle, L; Basham, S; Jefferson, AB; Appleton, BA; Lindvall, M; Shafer, CM Novartis Institutes for Biomedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50111372 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50111372&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 91844463 104005980 CHEMBL3604771 ZINC13440462 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 51139606 CN1CCN(CC1)c1ccc(cc1)-c1c(cnc2[nH]ccc12)-c1cn[nH]c1 InChI=1S/C21H22N6/c1-26-8-10-27(11-9-26)17-4-2-15(3-5-17)20-18-6-7-22-21(18)23-14-19(20)16-12-24-25-13-16/h2-7,12-14H,8-11H2,1H3,(H,22,23)(H,24,25) GVBJNYJFQAEXCP-UHFFFAOYSA-N 50467101 CHEMBL4280695 Ribosomal protein S6 kinase alpha-3 Homo sapiens 240 ChEMBL 10.1016/j.bmcl.2018.08.020 10.7270/Q2F76G78 30170943 Jain, R; Mathur, M; Lan, J; Costales, A; Atallah, G; Ramurthy, S; Subramanian, S; Setti, L; Feucht, P; Warne, B; Doyle, L; Basham, S; Jefferson, AB; Appleton, BA; Lindvall, M; Shafer, CM Novartis Institutes for Biomedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50467101 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50467101&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 145979228 433934366 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 51139607 CN1CCN(CC1)c1ccc(cc1)-c1c(cnc2[nH]ccc12)-c1ccnc(F)c1 InChI=1S/C23H22FN5/c1-28-10-12-29(13-11-28)18-4-2-16(3-5-18)22-19-7-9-26-23(19)27-15-20(22)17-6-8-25-21(24)14-17/h2-9,14-15H,10-13H2,1H3,(H,26,27) AJYZYCRPVRWXHJ-UHFFFAOYSA-N 50467102 CHEMBL4287512 Ribosomal protein S6 kinase alpha-3 Homo sapiens 1100 ChEMBL 10.1016/j.bmcl.2018.08.020 10.7270/Q2F76G78 30170943 Jain, R; Mathur, M; Lan, J; Costales, A; Atallah, G; Ramurthy, S; Subramanian, S; Setti, L; Feucht, P; Warne, B; Doyle, L; Basham, S; Jefferson, AB; Appleton, BA; Lindvall, M; Shafer, CM Novartis Institutes for Biomedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50467102 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50467102&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 145991585 433934367 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 51139608 CN1CCN(CC1)c1ccc(cc1)-c1c(cnc2[nH]ccc12)-c1cc(F)cc(F)c1 InChI=1S/C24H22F2N4/c1-29-8-10-30(11-9-29)20-4-2-16(3-5-20)23-21-6-7-27-24(21)28-15-22(23)17-12-18(25)14-19(26)13-17/h2-7,12-15H,8-11H2,1H3,(H,27,28) KBGVUVVNCOYRNB-UHFFFAOYSA-N 50467099 CHEMBL4284142 Ribosomal protein S6 kinase alpha-3 Homo sapiens 38 ChEMBL 10.1016/j.bmcl.2018.08.020 10.7270/Q2F76G78 30170943 Jain, R; Mathur, M; Lan, J; Costales, A; Atallah, G; Ramurthy, S; Subramanian, S; Setti, L; Feucht, P; Warne, B; Doyle, L; Basham, S; Jefferson, AB; Appleton, BA; Lindvall, M; Shafer, CM Novartis Institutes for Biomedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50467099 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50467099&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 145989941 433934364 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 51139609 CN1CCN(CC1)c1ccc(cc1)-c1c(cnc2[nH]ccc12)-c1cc(F)c(O)c(F)c1 InChI=1S/C24H22F2N4O/c1-29-8-10-30(11-9-29)17-4-2-15(3-5-17)22-18-6-7-27-24(18)28-14-19(22)16-12-20(25)23(31)21(26)13-16/h2-7,12-14,31H,8-11H2,1H3,(H,27,28) KJQYFARJBLRFQX-UHFFFAOYSA-N 50467097 CHEMBL4292020 Ribosomal protein S6 kinase alpha-3 Homo sapiens 0.300000 ChEMBL 10.1016/j.bmcl.2018.08.020 10.7270/Q2F76G78 30170943 Jain, R; Mathur, M; Lan, J; Costales, A; Atallah, G; Ramurthy, S; Subramanian, S; Setti, L; Feucht, P; Warne, B; Doyle, L; Basham, S; Jefferson, AB; Appleton, BA; Lindvall, M; Shafer, CM Novartis Institutes for Biomedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50467097 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50467097&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 145986466 433934362 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 51139610 Cc1ccc(cc1)-c1c(cnc2[nH]ccc12)-c1cc(F)c(O)c(F)c1 InChI=1S/C20H14F2N2O/c1-11-2-4-12(5-3-11)18-14-6-7-23-20(14)24-10-15(18)13-8-16(21)19(25)17(22)9-13/h2-10,25H,1H3,(H,23,24) MOMPHYXXCRRPRT-UHFFFAOYSA-N 50467103 CHEMBL4289492 Ribosomal protein S6 kinase alpha-3 Homo sapiens 2.0 ChEMBL 10.1016/j.bmcl.2018.08.020 10.7270/Q2F76G78 30170943 Jain, R; Mathur, M; Lan, J; Costales, A; Atallah, G; Ramurthy, S; Subramanian, S; Setti, L; Feucht, P; Warne, B; Doyle, L; Basham, S; Jefferson, AB; Appleton, BA; Lindvall, M; Shafer, CM Novartis Institutes for Biomedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50467103 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50467103&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 145986826 433934368 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 51139611 Oc1c(F)cc(cc1F)-c1cnccc1-c1ccc(cc1)N1CCOCC1 InChI=1S/C21H18F2N2O2/c22-19-11-15(12-20(23)21(19)26)18-13-24-6-5-17(18)14-1-3-16(4-2-14)25-7-9-27-10-8-25/h1-6,11-13,26H,7-10H2 YUYJEQHNWKQNBT-UHFFFAOYSA-N 50111384 CHEMBL3604794 Ribosomal protein S6 kinase alpha-3 Homo sapiens 4.0 ChEMBL 10.1016/j.bmcl.2018.08.020 10.7270/Q2F76G78 30170943 Jain, R; Mathur, M; Lan, J; Costales, A; Atallah, G; Ramurthy, S; Subramanian, S; Setti, L; Feucht, P; Warne, B; Doyle, L; Basham, S; Jefferson, AB; Appleton, BA; Lindvall, M; Shafer, CM Novartis Institutes for Biomedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50111384 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50111384&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 118704762 104005992 CHEMBL3604794 ZINC13440454 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 51139613 CN1CCN(CC1)c1ccc(cc1)-c1c(cnc2[nH]ccc12)-c1ccc(N)nc1 InChI=1S/C23H24N6/c1-28-10-12-29(13-11-28)18-5-2-16(3-6-18)22-19-8-9-25-23(19)27-15-20(22)17-4-7-21(24)26-14-17/h2-9,14-15H,10-13H2,1H3,(H2,24,26)(H,25,27) WMPCPCSYVGTSKK-UHFFFAOYSA-N 50467104 CHEMBL4288604 Ribosomal protein S6 kinase alpha-3 Homo sapiens 810 ChEMBL 10.1016/j.bmcl.2018.08.020 10.7270/Q2F76G78 30170943 Jain, R; Mathur, M; Lan, J; Costales, A; Atallah, G; Ramurthy, S; Subramanian, S; Setti, L; Feucht, P; Warne, B; Doyle, L; Basham, S; Jefferson, AB; Appleton, BA; Lindvall, M; Shafer, CM Novartis Institutes for Biomedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50467104 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50467104&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 145990304 433934369 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 51139615 CN1CCN(CC1)c1ccc(cc1)-c1ccncc1-c1cc(F)c(O)c(F)c1 InChI=1S/C22H21F2N3O/c1-26-8-10-27(11-9-26)17-4-2-15(3-5-17)18-6-7-25-14-19(18)16-12-20(23)22(28)21(24)13-16/h2-7,12-14,28H,8-11H2,1H3 IKUFKDGKRLMXEX-UHFFFAOYSA-N 50111385 CHEMBL3604793 Ribosomal protein S6 kinase alpha-3 Homo sapiens 5.0 ChEMBL 10.1016/j.bmcl.2018.08.020 10.7270/Q2F76G78 30170943 Jain, R; Mathur, M; Lan, J; Costales, A; Atallah, G; Ramurthy, S; Subramanian, S; Setti, L; Feucht, P; Warne, B; Doyle, L; Basham, S; Jefferson, AB; Appleton, BA; Lindvall, M; Shafer, CM Novartis Institutes for Biomedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50111385 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50111385&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 2NK 4NUS 73010393 104005993 CHEMBL3604793 ZINC13440451 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 51139616 CN1CCN(CC1)c1ccc(cc1)-c1c(cnc2[nH]ccc12)-c1ccc(N)nc1 InChI=1S/C23H24N6/c1-28-10-12-29(13-11-28)18-5-2-16(3-6-18)22-19-8-9-25-23(19)27-15-20(22)17-4-7-21(24)26-14-17/h2-9,14-15H,10-13H2,1H3,(H2,24,26)(H,25,27) WMPCPCSYVGTSKK-UHFFFAOYSA-N 50467104 CHEMBL4288604 Ribosomal protein S6 kinase alpha-3 Homo sapiens 7200 ChEMBL 10.1016/j.bmcl.2018.08.020 10.7270/Q2F76G78 30170943 Jain, R; Mathur, M; Lan, J; Costales, A; Atallah, G; Ramurthy, S; Subramanian, S; Setti, L; Feucht, P; Warne, B; Doyle, L; Basham, S; Jefferson, AB; Appleton, BA; Lindvall, M; Shafer, CM Novartis Institutes for Biomedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50467104 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50467104&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 145990304 433934369 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 51215994 OC(=O)C1CN(Cc2ccc(OCc3ccc(Cl)c(Cl)c3)cc2)C1 InChI=1S/C18H17Cl2NO3/c19-16-6-3-13(7-17(16)20)11-24-15-4-1-12(2-5-15)8-21-9-14(10-21)18(22)23/h1-7,14H,8-11H2,(H,22,23) WAAWETUDFSIYSD-UHFFFAOYSA-N 50499634 CHEMBL3741589 Ribosomal protein S6 kinase alpha-3 Homo sapiens >10000 ChEMBL 10.1021/acs.jmedchem.5b00928 10.7270/Q2PZ5CV4 26509640 Hobson, AD; Harris, CM; van der Kam, EL; Turner, SC; Abibi, A; Aguirre, AL; Bousquet, P; Kebede, T; Konopacki, DB; Gintant, G; Kim, Y; Larson, K; Maull, JW; Moore, NS; Shi, D; Shrestha, A; Tang, X; Zhang, P; Sarris, KK AbbVie Bioresearch Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50499634 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50499634&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 46872626 433911535 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 51234484 CO[C@@H]1[C@@H](C[C@H]2O[C@]1(C)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13)N(C)CCOCCOCCOCCNC(=O)CCC1=[N+]2C(C=C1)=Cc1c(C)cc(C)n1[B-]2(F)F InChI=1S/C50H56BF2N7O7/c1-30-26-31(2)59-39(30)27-33-15-14-32(60(33)51(59,52)53)16-17-41(61)54-18-20-64-22-24-66-25-23-65-21-19-56(4)40-28-42-57-37-12-8-6-10-34(37)44-45-36(29-55-49(45)62)43-35-11-7-9-13-38(35)58(47(43)46(44)57)50(3,67-42)48(40)63-5/h6-15,26-27,40,42,48H,16-25,28-29H2,1-5H3,(H,54,61)(H,55,62)/t40-,42-,48-,50+/m1/s1 OSVUGUHRKMMBSE-INMRTLOZSA-N 50505542 CHEMBL4576489 Ribosomal protein S6 kinase alpha-3 Homo sapiens 2.0 ChEMBL 10.1016/j.bmcl.2019.126641 10.7270/Q2RV0S0K 31526603 Hirozane, Y; Toyofuku, M; Yogo, T; Tanaka, Y; Sameshima, T; Miyahisa, I; Yoshikawa, M Takeda Pharmaceutical Company Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50505542 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50505542&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 155552127 440714127 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 51234497 CO[C@@H]1[C@@H](C[C@H]2O[C@]1(C)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13)NCCOCCOCCOCCNC(=O)CCC1=[N+]2C(C=C1)=Cc1c(C)cc(C)n1[B-]2(F)F InChI=1S/C49H54BF2N7O7/c1-29-25-30(2)58-39(29)26-32-14-13-31(59(32)50(58,51)52)15-16-40(60)54-18-20-64-22-24-65-23-21-63-19-17-53-36-27-41-56-37-11-7-5-9-33(37)43-44-35(28-55-48(44)61)42-34-10-6-8-12-38(34)57(46(42)45(43)56)49(3,66-41)47(36)62-4/h5-14,25-26,36,41,47,53H,15-24,27-28H2,1-4H3,(H,54,60)(H,55,61)/t36-,41-,47-,49+/m1/s1 NXSJMRCTGYTSTK-SQHKIPTKSA-N 50505541 CHEMBL4465866 Ribosomal protein S6 kinase alpha-3 Homo sapiens 4.0 ChEMBL 10.1016/j.bmcl.2019.126641 10.7270/Q2RV0S0K 31526603 Hirozane, Y; Toyofuku, M; Yogo, T; Tanaka, Y; Sameshima, T; Miyahisa, I; Yoshikawa, M Takeda Pharmaceutical Company Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50505541 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50505541&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 155531579 440714126 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 51238695 CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1 HKSZLNNOFSGOKW-FYTWVXJKSA-N 2579 (2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.1^{2,6}.0^{7,28}.0^{8,13}.0^{15,19}.0^{20,27}.0^{21,26}]nonacosa-8(13),9,11,14(28),15(19),20(27),21(26),22,24-nonaen-16-one::CHEMBL388978::Staurosporin, 4::Staurosporine::Staurosporine, 8::US9206188, Staurosporine::US9226923, Staurosporine Ribosomal protein S6 kinase alpha-3 Homo sapiens 0.124 ChEMBL 10.1016/j.ejmech.2018.10.052 10.7270/Q2W380MT 30384048 Narayan, S; Ramisetti, S; Jaiswal, AS; Law, BK; Singh-Pillay, A; Singh, P; Amin, S; Sharma, AK University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=2579 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=2579&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search STO 1AQ1,1BYG,1E8Z,1NVR,1NXK,1OKY,1Q3D,1QPD,1QPJ,1SM2,1SNU,1STC,1U59,1WVY,1XBC,1XJD,1YHS,2BUJ,2CLQ,2DQ7,2GCD,2HW7,2ITQ,2ITU,2ITW,2NRY,2OIC 44259 8032349 15738 CHEMBL388978 346 C02079 ZINC03814434 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 51273132 CN(C)c1ccc(cc1)C(=O)Nc1cccc(NC(=O)COc2ccc3c(c2)occc3=O)c1 InChI=1S/C26H23N3O5/c1-29(2)20-8-6-17(7-9-20)26(32)28-19-5-3-4-18(14-19)27-25(31)16-34-21-10-11-22-23(30)12-13-33-24(22)15-21/h3-15H,16H2,1-2H3,(H,27,31)(H,28,32) WVGDUQVQWLHVEA-UHFFFAOYSA-N 50519662 CHEMBL4438748 Ribosomal protein S6 kinase alpha-3 Homo sapiens >10000 ChEMBL 10.1021/acs.jmedchem.9b01143 10.7270/Q2MC93FG 31693351 Zhao, L; Li, Y; Wang, Y; Qiao, Z; Miao, Z; Yang, J; Huang, L; Tian, C; Li, L; Chen, D; Yang, S TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50519662 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50519662&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 155513187 440728244 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 51326398 Cc1sc(cc1-c1cnn2cc(Cl)cnc12)C(=O)N[C@@H]1[C@H](N)CCCC1(F)F InChI=1S/C18H18ClF2N5OS/c1-9-11(12-7-24-26-8-10(19)6-23-16(12)26)5-14(28-9)17(27)25-15-13(22)3-2-4-18(15,20)21/h5-8,13,15H,2-4,22H2,1H3,(H,25,27)/t13-,15-/m1/s1 NGFGTMFVWSDFPS-UKRRQHHQSA-N 50536681 CHEMBL4552628 Ribosomal protein S6 kinase alpha-3 Homo sapiens 47 ChEMBL 10.1016/j.bmcl.2016.02.003 10.7270/Q2NP27X5 27491711 Sloman, DL; Noucti, N; Altman, MD; Chen, D; Mislak, AC; Szewczak, A; Hayashi, M; Warren, L; Dellovade, T; Wu, Z; Marcus, J; Walker, D; Su, HP; Edavettal, SC; Munshi, S; Hutton, M; Nuthall, H; Stanton, MG Merck and Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50536681 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50536681&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 89735655 440827505 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 51326542 Cn1cc(cn1)-c1cnc2c(cnn2c1)-c1csc(c1)C(=O)NCC(F)(F)F InChI=1S/C17H13F3N6OS/c1-25-6-12(4-23-25)11-3-21-15-13(5-24-26(15)7-11)10-2-14(28-8-10)16(27)22-9-17(18,19)20/h2-8H,9H2,1H3,(H,22,27) UEFCSGDOOJJXTN-UHFFFAOYSA-N 50536678 CHEMBL4550702 Ribosomal protein S6 kinase alpha-3 Homo sapiens 380 ChEMBL 10.1016/j.bmcl.2016.02.003 10.7270/Q2NP27X5 27491711 Sloman, DL; Noucti, N; Altman, MD; Chen, D; Mislak, AC; Szewczak, A; Hayashi, M; Warren, L; Dellovade, T; Wu, Z; Marcus, J; Walker, D; Su, HP; Edavettal, SC; Munshi, S; Hutton, M; Nuthall, H; Stanton, MG Merck and Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50536678 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50536678&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 59603829 440827502 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 51326659 Cn1cc(cn1)-c1cnc2c(cnn2c1)-c1csc(c1)C(=O)N[C@@H]1CCCC[C@@H]1N InChI=1S/C21H23N7OS/c1-27-10-15(8-24-27)14-7-23-20-16(9-25-28(20)11-14)13-6-19(30-12-13)21(29)26-18-5-3-2-4-17(18)22/h6-12,17-18H,2-5,22H2,1H3,(H,26,29)/t17-,18+/m0/s1 LYADGAGFYYXXIO-ZWKOTPCHSA-N 50536679 CHEMBL4568087 Ribosomal protein S6 kinase alpha-3 Homo sapiens <1.000000 ChEMBL 10.1016/j.bmcl.2016.02.003 10.7270/Q2NP27X5 27491711 Sloman, DL; Noucti, N; Altman, MD; Chen, D; Mislak, AC; Szewczak, A; Hayashi, M; Warren, L; Dellovade, T; Wu, Z; Marcus, J; Walker, D; Su, HP; Edavettal, SC; Munshi, S; Hutton, M; Nuthall, H; Stanton, MG Merck and Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50536679 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50536679&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 59603842 440827503 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 51326247 FC(F)(F)CNC(=O)c1cc(cs1)-c1cnn2cc(cnc12)-c1ccc(OCCN2CCCCC2)cc1 InChI=1S/C26H26F3N5O2S/c27-26(28,29)17-31-25(35)23-12-19(16-37-23)22-14-32-34-15-20(13-30-24(22)34)18-4-6-21(7-5-18)36-11-10-33-8-2-1-3-9-33/h4-7,12-16H,1-3,8-11,17H2,(H,31,35) QNABDSWBQJKBHK-UHFFFAOYSA-N 50536675 CHEMBL4569508 Ribosomal protein S6 kinase alpha-3 Homo sapiens 260 ChEMBL 10.1016/j.bmcl.2016.02.003 10.7270/Q2NP27X5 27491711 Sloman, DL; Noucti, N; Altman, MD; Chen, D; Mislak, AC; Szewczak, A; Hayashi, M; Warren, L; Dellovade, T; Wu, Z; Marcus, J; Walker, D; Su, HP; Edavettal, SC; Munshi, S; Hutton, M; Nuthall, H; Stanton, MG Merck and Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50536675 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50536675&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 24759534 440827499 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 947089 C[C@@H]1CNC(=O)c2cc3ccc(nc3n12)C(=O)Nc1cnn(Cc2ccc(N)cc2)c1 InChI=1S/C27H29N7O4/c1-16-12-28-25(36)22-11-18-7-10-21(32-23(18)34(16)22)24(35)30-20-13-29-33(15-20)14-17-5-8-19(9-6-17)31-26(37)38-27(2,3)4/h5-11,13,15-16H,12,14H2,1-4H3,(H,28,36)(H,30,35)(H,31,37)/t16-/m1/s1 DPHPBJAORBZVTM-MRXNPFEDSA-N 286091 (R)¿N-(1-(4-aminobenzyl)-1H-pyrazol-4-yl)-9-methyl-6-oxo-6,7,8,9-tetrahydropyrido[3′,2′:4,5]pyrrolo[1,2-a]pyrazine-2-carboxamide::BDBM286094::US10081632, Compound 18::US10758530, Compound 18 Ribosomal protein S6 kinase alpha-3 Homo sapiens 1.7 US Patent 10.7270/Q20R9SGD aid1804743 US10758530 Dunn, SE; Jayanthan, A; Nagireddy, JR; Annedi, S; Van Drie, JH; Daynard, TS; Huynh, M PHOENIX MOLECULAR DESIGNS http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=286091 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=286091&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 130338820 378169688 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 947092 C[C@@H]1CNC(=O)c2cc3ccc(NC(=O)c4cnn(Cc5ccccc5)c4)nc3n12 InChI=1S/C22H20N6O2/c1-14-10-23-22(30)18-9-16-7-8-19(25-20(16)28(14)18)26-21(29)17-11-24-27(13-17)12-15-5-3-2-4-6-15/h2-9,11,13-14H,10,12H2,1H3,(H,23,30)(H,25,26,29)/t14-/m1/s1 XYMNFMNOEWBPNB-CQSZACIVSA-N 458758 (R)-1-benzyl-N-(9-methyl-6-oxo-6,7,8,9-tetrahydropyrido[3′,2′:4,5]pyrrolo[1,2-a]pyrazin-2-yl)-1H-pyrazole-4-carboxamide::US10758530, Compound 15 Ribosomal protein S6 kinase alpha-3 Homo sapiens 6.0 US Patent 10.7270/Q20R9SGD aid1804743 US10758530 Dunn, SE; Jayanthan, A; Nagireddy, JR; Annedi, S; Van Drie, JH; Daynard, TS; Huynh, M PHOENIX MOLECULAR DESIGNS http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=458758 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=458758&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 130338874 441290023 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 50563856 C[C@@H]1C[C@H]1C(=O)N1CCN(C[C@H]1C)c1cnc(C#N)c(n1)-c1cnn(C)c1 InChI=1S/C19H23N7O/c1-12-6-15(12)19(27)26-5-4-25(10-13(26)2)17-9-21-16(7-20)18(23-17)14-8-22-24(3)11-14/h8-9,11-13,15H,4-6,10H2,1-3H3/t12-,13-,15-/m1/s1 GXEXIUKEWXZCEF-UMVBOHGHSA-N 50537742 CHEMBL4634634::US11179389, Compound 1-14 Ribosomal protein S6 kinase alpha-3 Homo sapiens 29080 ChEMBL 10.1016/j.bmcl.2019.126715 10.7270/Q2HM5CZG 31757666 Zhou, H; McGowan, MA; Lipford, K; Christopher, M; Fradera, X; Witter, D; Lesburg, CA; Li, C; Methot, JL; Lampe, J; Achab, A; Shaffer, L; Goldenblatt, P; Shah, S; Bass, A; Schroeder, G; Chen, D; Zeng, H; Augustin, MA; Katz, JD Merck & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50537742 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50537742&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 5D 6OCU 145704650 442139305 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 51328932 Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COC(=O)c2ccc[nH]2)[C@@H](O)[C@H]1O 50537885 CHEMBL4633057 Ribosomal protein S6 kinase alpha-3 Homo sapiens 800 ChEMBL 10.1021/acs.jnatprod.9b01231 10.7270/Q2BZ69JJ 31961676 Bracegirdle, J; Gordon, DP; Harvey, JE; Keyzers, RA Victoria University of Wellington http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50537885 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50537885&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 156010729 442139448 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 51328933 O[C@@H]1[C@@H](COC(=O)c2ccc[nH]2)O[C@H]([C@@H]1O)n1cnc2c1nc[nH]c2=O 50537887 CHEMBL4636133 Ribosomal protein S6 kinase alpha-3 Homo sapiens 230 ChEMBL 10.1021/acs.jnatprod.9b01231 10.7270/Q2BZ69JJ 31961676 Bracegirdle, J; Gordon, DP; Harvey, JE; Keyzers, RA Victoria University of Wellington http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50537887 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50537887&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 156013658 442139450 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 51328934 Nc1nc2n(cnc2c(=O)[nH]1)[C@@H]1O[C@H](COC(=O)c2ccc[nH]2)[C@@H](O)[C@H]1O 50537884 CHEMBL4642516 Ribosomal protein S6 kinase alpha-3 Homo sapiens 660 ChEMBL 10.1021/acs.jnatprod.9b01231 10.7270/Q2BZ69JJ 31961676 Bracegirdle, J; Gordon, DP; Harvey, JE; Keyzers, RA Victoria University of Wellington http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50537884 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50537884&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 156016940 442139447 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 51328935 Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COC(=O)c2cc[nH]c2)[C@@H](O)[C@H]1O 50537886 CHEMBL4647499 Ribosomal protein S6 kinase alpha-3 Homo sapiens 970 ChEMBL 10.1021/acs.jnatprod.9b01231 10.7270/Q2BZ69JJ 31961676 Bracegirdle, J; Gordon, DP; Harvey, JE; Keyzers, RA Victoria University of Wellington http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50537886 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50537886&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 156019981 442139449 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 51328936 O[C@@H]1[C@@H](COC(=O)c2cc[nH]c2)O[C@H]([C@@H]1O)n1cnc2c1nc[nH]c2=O 50537883 CHEMBL4637966 Ribosomal protein S6 kinase alpha-3 Homo sapiens 640 ChEMBL 10.1021/acs.jnatprod.9b01231 10.7270/Q2BZ69JJ 31961676 Bracegirdle, J; Gordon, DP; Harvey, JE; Keyzers, RA Victoria University of Wellington http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50537883 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50537883&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 156012023 442139446 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 51328937 Nc1nc2n(cnc2c(=O)[nH]1)[C@@H]1O[C@H](COC(=O)c2cc[nH]c2)[C@@H](O)[C@H]1O 50537882 CHEMBL4634615 Ribosomal protein S6 kinase alpha-3 Homo sapiens 680 ChEMBL 10.1021/acs.jnatprod.9b01231 10.7270/Q2BZ69JJ 31961676 Bracegirdle, J; Gordon, DP; Harvey, JE; Keyzers, RA Victoria University of Wellington http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50537882 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50537882&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 156009620 442139445 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 51342610 CC(C)CCN1C(C)C(=O)N(C)c2cnc(Nc3cc(F)c(O)c(F)c3)nc12 InChI=1S/C19H23F2N5O2/c1-10(2)5-6-26-11(3)18(28)25(4)15-9-22-19(24-17(15)26)23-12-7-13(20)16(27)14(21)8-12/h7-11,27H,5-6H2,1-4H3,(H,22,23,24) DTEKTGDVSARYDS-UHFFFAOYSA-N 25017 2-[(3,5-difluoro-4-hydroxyphenyl)amino]-5,7-dimethyl-8-(3-methylbutyl)-5,6,7,8-tetrahydropteridin-6-one::BI-D1870 Ribosomal protein S6 kinase alpha-3 Homo sapiens 23300 ChEMBL 10.1016/j.bmc.2019.115303 10.7270/Q2XW4PCP 31982240 Casalvieri, KA; Matheson, CJ; Backos, DS; Reigan, P University of Colorado Anschutz Medical Campus http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25017 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25017&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 584 5WIK,5D9K,7N7L 25023738 56374161 ZINC33359423 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 51342611 CC(C)CCN1C(C)C(=O)N(C)c2cnc(Nc3ccc(CO)cc3)nc12 InChI=1S/C20H27N5O2/c1-13(2)9-10-25-14(3)19(27)24(4)17-11-21-20(23-18(17)25)22-16-7-5-15(12-26)6-8-16/h5-8,11,13-14,26H,9-10,12H2,1-4H3,(H,21,22,23) AQNQUMXNCYHCBB-UHFFFAOYSA-N 50543499 CHEMBL4645183 Ribosomal protein S6 kinase alpha-3 Homo sapiens 739000 ChEMBL 10.1016/j.bmc.2019.115303 10.7270/Q2XW4PCP 31982240 Casalvieri, KA; Matheson, CJ; Backos, DS; Reigan, P University of Colorado Anschutz Medical Campus http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50543499 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50543499&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 156018732 442145062 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 51342612 CC(C)CCN1C(C)C(=O)N(C)c2cnc(Nc3ccc(O)cc3)nc12 InChI=1S/C19H25N5O2/c1-12(2)9-10-24-13(3)18(26)23(4)16-11-20-19(22-17(16)24)21-14-5-7-15(25)8-6-14/h5-8,11-13,25H,9-10H2,1-4H3,(H,20,21,22) SYAVITDEMCFFQU-UHFFFAOYSA-N 50543500 CHEMBL4643216 Ribosomal protein S6 kinase alpha-3 Homo sapiens 54800 ChEMBL 10.1016/j.bmc.2019.115303 10.7270/Q2XW4PCP 31982240 Casalvieri, KA; Matheson, CJ; Backos, DS; Reigan, P University of Colorado Anschutz Medical Campus http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50543500 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50543500&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 156018890 442145063 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 51342613 CC(C)CCN1C(C)C(=O)N(C)c2cnc(Nc3ccc(O)c(F)c3)nc12 InChI=1S/C19H24FN5O2/c1-11(2)7-8-25-12(3)18(27)24(4)15-10-21-19(23-17(15)25)22-13-5-6-16(26)14(20)9-13/h5-6,9-12,26H,7-8H2,1-4H3,(H,21,22,23) SXXZIEUJNXRXDY-UHFFFAOYSA-N 50543501 CHEMBL4645589 Ribosomal protein S6 kinase alpha-3 Homo sapiens 25400 ChEMBL 10.1016/j.bmc.2019.115303 10.7270/Q2XW4PCP 31982240 Casalvieri, KA; Matheson, CJ; Backos, DS; Reigan, P University of Colorado Anschutz Medical Campus http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50543501 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50543501&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 156019184 442145064 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 51342614 CC(C)CCN1C(C)C(=O)N(C)c2cnc(Nc3ccc(O)c(Cl)c3)nc12 InChI=1S/C19H24ClN5O2/c1-11(2)7-8-25-12(3)18(27)24(4)15-10-21-19(23-17(15)25)22-13-5-6-16(26)14(20)9-13/h5-6,9-12,26H,7-8H2,1-4H3,(H,21,22,23) DTUPRAFOBRBEJH-UHFFFAOYSA-N 50543502 CHEMBL4641669 Ribosomal protein S6 kinase alpha-3 Homo sapiens 71500 ChEMBL 10.1016/j.bmc.2019.115303 10.7270/Q2XW4PCP 31982240 Casalvieri, KA; Matheson, CJ; Backos, DS; Reigan, P University of Colorado Anschutz Medical Campus http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50543502 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50543502&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 156016281 442145065 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 51342615 CC(C)CCN1C(C)C(=O)N(C)c2cnc(Nc3ccc(O)c(Br)c3)nc12 InChI=1S/C19H24BrN5O2/c1-11(2)7-8-25-12(3)18(27)24(4)15-10-21-19(23-17(15)25)22-13-5-6-16(26)14(20)9-13/h5-6,9-12,26H,7-8H2,1-4H3,(H,21,22,23) ZGBPERUKZUUFIZ-UHFFFAOYSA-N 50543503 CHEMBL4641310 Ribosomal protein S6 kinase alpha-3 Homo sapiens 141000 ChEMBL 10.1016/j.bmc.2019.115303 10.7270/Q2XW4PCP 31982240 Casalvieri, KA; Matheson, CJ; Backos, DS; Reigan, P University of Colorado Anschutz Medical Campus http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50543503 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50543503&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 156016492 442145066 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 51342616 CC(C)CCN1C(C)C(=O)Nc2cnc(Nc3cc(F)c(O)c(F)c3)nc12 InChI=1S/C18H21F2N5O2/c1-9(2)4-5-25-10(3)17(27)23-14-8-21-18(24-16(14)25)22-11-6-12(19)15(26)13(20)7-11/h6-10,26H,4-5H2,1-3H3,(H,23,27)(H,21,22,24) YEMJIKMBTXBKRR-UHFFFAOYSA-N 50543504 CHEMBL4643363 Ribosomal protein S6 kinase alpha-3 Homo sapiens 18200 ChEMBL 10.1016/j.bmc.2019.115303 10.7270/Q2XW4PCP 31982240 Casalvieri, KA; Matheson, CJ; Backos, DS; Reigan, P University of Colorado Anschutz Medical Campus http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50543504 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50543504&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 156018260 442145067 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 51342617 CC(C)CCN1CC(=O)N(C)c2cnc(Nc3cc(F)c(O)c(F)c3)nc12 InChI=1S/C18H21F2N5O2/c1-10(2)4-5-25-9-15(26)24(3)14-8-21-18(23-17(14)25)22-11-6-12(19)16(27)13(20)7-11/h6-8,10,27H,4-5,9H2,1-3H3,(H,21,22,23) FFYNGMDUPIRSOX-UHFFFAOYSA-N 50543505 CHEMBL4648201 Ribosomal protein S6 kinase alpha-3 Homo sapiens 17600 ChEMBL 10.1016/j.bmc.2019.115303 10.7270/Q2XW4PCP 31982240 Casalvieri, KA; Matheson, CJ; Backos, DS; Reigan, P University of Colorado Anschutz Medical Campus http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50543505 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50543505&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 156021753 442145068 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 51342618 CC(C)CCN1CC(=O)Nc2cnc(Nc3ccc(O)c(F)c3)nc12 InChI=1S/C17H20FN5O2/c1-10(2)5-6-23-9-15(25)21-13-8-19-17(22-16(13)23)20-11-3-4-14(24)12(18)7-11/h3-4,7-8,10,24H,5-6,9H2,1-2H3,(H,21,25)(H,19,20,22) PTGVDPDATIDBBQ-UHFFFAOYSA-N 50543506 CHEMBL4647466 Ribosomal protein S6 kinase alpha-3 Homo sapiens 38300 ChEMBL 10.1016/j.bmc.2019.115303 10.7270/Q2XW4PCP 31982240 Casalvieri, KA; Matheson, CJ; Backos, DS; Reigan, P University of Colorado Anschutz Medical Campus http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50543506 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50543506&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 156021580 442145069 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 51342619 CC(C)CCN1CC(=O)Nc2cnc(Nc3cc(F)c(O)c(F)c3)nc12 InChI=1S/C17H19F2N5O2/c1-9(2)3-4-24-8-14(25)22-13-7-20-17(23-16(13)24)21-10-5-11(18)15(26)12(19)6-10/h5-7,9,26H,3-4,8H2,1-2H3,(H,22,25)(H,20,21,23) KXVXPQIDAGBPDU-UHFFFAOYSA-N 50543507 CHEMBL4644875 Ribosomal protein S6 kinase alpha-3 Homo sapiens 23400 ChEMBL 10.1016/j.bmc.2019.115303 10.7270/Q2XW4PCP 31982240 Casalvieri, KA; Matheson, CJ; Backos, DS; Reigan, P University of Colorado Anschutz Medical Campus http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50543507 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50543507&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 156018969 442145070 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 51342620 CC(C)CCN1CC(=O)N(C)c2cnc(Nc3ccc(O)c(F)c3)nc12 InChI=1S/C18H22FN5O2/c1-11(2)6-7-24-10-16(26)23(3)14-9-20-18(22-17(14)24)21-12-4-5-15(25)13(19)8-12/h4-5,8-9,11,25H,6-7,10H2,1-3H3,(H,20,21,22) DQKBXSPQZBCQMB-UHFFFAOYSA-N 50543508 CHEMBL4643631 Ribosomal protein S6 kinase alpha-3 Homo sapiens 24700 ChEMBL 10.1016/j.bmc.2019.115303 10.7270/Q2XW4PCP 31982240 Casalvieri, KA; Matheson, CJ; Backos, DS; Reigan, P University of Colorado Anschutz Medical Campus http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50543508 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50543508&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 156018773 442145071 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 51342622 CC(C)CCN1C(C)C(=O)N(C)c2cnc(Nc3cc(F)c(O)c(F)c3)nc12 InChI=1S/C19H23F2N5O2/c1-10(2)5-6-26-11(3)18(28)25(4)15-9-22-19(24-17(15)26)23-12-7-13(20)16(27)14(21)8-12/h7-11,27H,5-6H2,1-4H3,(H,22,23,24) DTEKTGDVSARYDS-UHFFFAOYSA-N 25017 2-[(3,5-difluoro-4-hydroxyphenyl)amino]-5,7-dimethyl-8-(3-methylbutyl)-5,6,7,8-tetrahydropteridin-6-one::BI-D1870 Ribosomal protein S6 kinase alpha-3 Homo sapiens 24 ChEMBL 10.1016/j.bmc.2019.115303 10.7270/Q2XW4PCP 31982240 Casalvieri, KA; Matheson, CJ; Backos, DS; Reigan, P University of Colorado Anschutz Medical Campus http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25017 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25017&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 584 5WIK,5D9K,7N7L 25023738 56374161 ZINC33359423 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 51342627 CC(C)CCN1C(C)C(=O)N(C)c2cnc(Nc3cc(F)c(O)c(F)c3)nc12 InChI=1S/C19H23F2N5O2/c1-10(2)5-6-26-11(3)18(28)25(4)15-9-22-19(24-17(15)26)23-12-7-13(20)16(27)14(21)8-12/h7-11,27H,5-6H2,1-4H3,(H,22,23,24) DTEKTGDVSARYDS-UHFFFAOYSA-N 25017 2-[(3,5-difluoro-4-hydroxyphenyl)amino]-5,7-dimethyl-8-(3-methylbutyl)-5,6,7,8-tetrahydropteridin-6-one::BI-D1870 Ribosomal protein S6 kinase alpha-3 Homo sapiens 4.0 ChEMBL 10.1016/j.bmc.2019.115303 10.7270/Q2XW4PCP 31982240 Casalvieri, KA; Matheson, CJ; Backos, DS; Reigan, P University of Colorado Anschutz Medical Campus http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25017 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25017&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 584 5WIK,5D9K,7N7L 25023738 56374161 ZINC33359423 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 51342628 Oc1c(F)cc(cc1F)-c1cnccc1-c1ccc(cc1)N1CCOCC1 InChI=1S/C21H18F2N2O2/c22-19-11-15(12-20(23)21(19)26)18-13-24-6-5-17(18)14-1-3-16(4-2-14)25-7-9-27-10-8-25/h1-6,11-13,26H,7-10H2 YUYJEQHNWKQNBT-UHFFFAOYSA-N 50111384 CHEMBL3604794 Ribosomal protein S6 kinase alpha-3 Homo sapiens 5.0 ChEMBL 10.1016/j.bmc.2019.115303 10.7270/Q2XW4PCP 31982240 Casalvieri, KA; Matheson, CJ; Backos, DS; Reigan, P University of Colorado Anschutz Medical Campus http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50111384 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50111384&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 118704762 104005992 CHEMBL3604794 ZINC13440454 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 51395528 Cc1ccc(NC(=O)c2ccc(C)c(c2)C(F)(F)F)cc1C#Cc1nn([C@H]2CC[C@H](O)CC2)c2ncnc(N)c12 InChI=1S/C29H27F3N6O2/c1-16-4-7-20(36-28(40)19-5-3-17(2)23(14-19)29(30,31)32)13-18(16)6-12-24-25-26(33)34-15-35-27(25)38(37-24)21-8-10-22(39)11-9-21/h3-5,7,13-15,21-22,39H,8-11H2,1-2H3,(H,36,40)(H2,33,34,35)/t21-,22- YHVHYWYQEFELOW-HZCBDIJESA-N 378885 US10266537, Compound 93 Ribosomal protein S6 kinase alpha-3 Homo sapiens >10000 ChEMBL 10.1021/acs.jmedchem.6b00943 10.7270/Q2M90DC6 27739679 Zhang, CH; Chen, K; Jiao, Y; Li, LL; Li, YP; Zhang, RJ; Zheng, MW; Zhong, L; Huang, SZ; Song, CL; Lin, WT; Yang, J; Xiang, R; Peng, B; Han, JH; Lu, GW; Wei, YQ; Yang, SY Sichuan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=378885 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=378885&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 122419211 404338880 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 51382581 Nc1ncnc2n(CC3CCN(CC3)C(=O)C=C)cc(-c3ccc4OCOc4c3)c12 InChI=1S/C22H23N5O3/c1-2-19(28)26-7-5-14(6-8-26)10-27-11-16(20-21(23)24-12-25-22(20)27)15-3-4-17-18(9-15)30-13-29-17/h2-4,9,11-12,14H,1,5-8,10,13H2,(H2,23,24,25) RMTJSBZCZKCYHB-UHFFFAOYSA-N 50558812 CHEMBL4755698 Ribosomal protein S6 kinase alpha-3 Homo sapiens >10000 ChEMBL 10.1016/j.ejmech.2017.12.079 10.7270/Q2P272TR 29324347 He, L; Pei, H; Zhang, C; Shao, M; Li, D; Tang, M; Wang, T; Chen, X; Xiang, M; Chen, L Sichuan University and Collaborative Innovation Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50558812 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50558812&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 162655720 461829204 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 51382684 CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1 HKSZLNNOFSGOKW-FYTWVXJKSA-N 2579 (2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.1^{2,6}.0^{7,28}.0^{8,13}.0^{15,19}.0^{20,27}.0^{21,26}]nonacosa-8(13),9,11,14(28),15(19),20(27),21(26),22,24-nonaen-16-one::CHEMBL388978::Staurosporin, 4::Staurosporine::Staurosporine, 8::US9206188, Staurosporine::US9226923, Staurosporine Ribosomal protein S6 kinase alpha-3 Homo sapiens 0.080 ChEMBL 10.1016/j.bmc.2018.02.022 10.7270/Q2DJ5KB8 29523467 Hou, W; Ren, Y; Zhang, Z; Sun, H; Ma, Y; Yan, B Beijing Normal University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=2579 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=2579&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search STO 1AQ1,1BYG,1E8Z,1NVR,1NXK,1OKY,1Q3D,1QPD,1QPJ,1SM2,1SNU,1STC,1U59,1WVY,1XBC,1XJD,1YHS,2BUJ,2CLQ,2DQ7,2GCD,2HW7,2ITQ,2ITU,2ITW,2NRY,2OIC 44259 8032349 15738 CHEMBL388978 346 C02079 ZINC03814434 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 51368100 Nc1cccc2cc[nH]c(=O)c12 InChI=1S/C9H8N2O/c10-7-3-1-2-6-4-5-11-9(12)8(6)7/h1-5H,10H2,(H,11,12) UXMPRYSFGIABNF-UHFFFAOYSA-N 50553103 CHEMBL4784866 Ribosomal protein S6 kinase alpha-3 Homo sapiens 16500 ChEMBL 10.1039/c9md00519f 10.7270/Q2TQ655W 33479656 Rachman, M; Bajusz, D; Hetényi, A; Scarpino, A; MerÅ‘, B; Egyed, A; Buday, L; Barril, X; Keserű, GM Universitat de Barcelona http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50553103 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50553103&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 15541817 461691871 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 51406022 CC(C)CCN1C(C)C(=O)N(C)c2cnc(Nc3cc(F)c(O)c(F)c3)nc12 InChI=1S/C19H23F2N5O2/c1-10(2)5-6-26-11(3)18(28)25(4)15-9-22-19(24-17(15)26)23-12-7-13(20)16(27)14(21)8-12/h7-11,27H,5-6H2,1-4H3,(H,22,23,24) DTEKTGDVSARYDS-UHFFFAOYSA-N 25017 2-[(3,5-difluoro-4-hydroxyphenyl)amino]-5,7-dimethyl-8-(3-methylbutyl)-5,6,7,8-tetrahydropteridin-6-one::BI-D1870 Ribosomal protein S6 kinase alpha-3 Homo sapiens 23 ChEMBL 10.1016/j.bmc.2021.116220 10.7270/Q2H70KKB 34034149 Casalvieri, KA; Matheson, CJ; Warfield, BM; Backos, DS; Reigan, P University of Colorado Anschutz Medical Campus http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25017 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25017&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 584 5WIK,5D9K,7N7L 25023738 56374161 ZINC33359423 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 51406023 CC(C)CCn1cnc2cnc(Nc3cc(F)c(O)c(F)c3)nc12 InChI=1S/C16H17F2N5O/c1-9(2)3-4-23-8-20-13-7-19-16(22-15(13)23)21-10-5-11(17)14(24)12(18)6-10/h5-9,24H,3-4H2,1-2H3,(H,19,21,22) OYTSXCFOGSTFSE-UHFFFAOYSA-N 50568104 CHEMBL4858257 Ribosomal protein S6 kinase alpha-3 Homo sapiens 56 ChEMBL 10.1016/j.bmc.2021.116220 10.7270/Q2H70KKB 34034149 Casalvieri, KA; Matheson, CJ; Warfield, BM; Backos, DS; Reigan, P University of Colorado Anschutz Medical Campus http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50568104 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50568104&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 164609895 471058249 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 51406024 Oc1c(F)cc(Nc2ncc3ncn(-c4ccc(cc4)N4CCOCC4)c3n2)cc1F InChI=1S/C21H18F2N6O2/c22-16-9-13(10-17(23)19(16)30)26-21-24-11-18-20(27-21)29(12-25-18)15-3-1-14(2-4-15)28-5-7-31-8-6-28/h1-4,9-12,30H,5-8H2,(H,24,26,27) AZIATJQXGGRMIL-UHFFFAOYSA-N 50568105 CHEMBL4858455 Ribosomal protein S6 kinase alpha-3 Homo sapiens 25 ChEMBL 10.1016/j.bmc.2021.116220 10.7270/Q2H70KKB 34034149 Casalvieri, KA; Matheson, CJ; Warfield, BM; Backos, DS; Reigan, P University of Colorado Anschutz Medical Campus http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50568105 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50568105&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 164613626 471058250 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 51406025 Oc1c(F)cc(Nc2ncc3ncn(-c4ccc(CCN5CCOCC5)cc4)c3n2)cc1F InChI=1S/C23H22F2N6O2/c24-18-11-16(12-19(25)21(18)32)28-23-26-13-20-22(29-23)31(14-27-20)17-3-1-15(2-4-17)5-6-30-7-9-33-10-8-30/h1-4,11-14,32H,5-10H2,(H,26,28,29) UWGYODGLBGTABR-UHFFFAOYSA-N 50568106 CHEMBL4849660 Ribosomal protein S6 kinase alpha-3 Homo sapiens 18 ChEMBL 10.1016/j.bmc.2021.116220 10.7270/Q2H70KKB 34034149 Casalvieri, KA; Matheson, CJ; Warfield, BM; Backos, DS; Reigan, P University of Colorado Anschutz Medical Campus http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50568106 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50568106&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 164611094 471058251 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 51406026 Oc1c(F)cc(Nc2ncc3ncn(-c4cccc(Oc5ccccc5)c4)c3n2)cc1F InChI=1S/C23H15F2N5O2/c24-18-9-14(10-19(25)21(18)31)28-23-26-12-20-22(29-23)30(13-27-20)15-5-4-8-17(11-15)32-16-6-2-1-3-7-16/h1-13,31H,(H,26,28,29) KVYJDRGXUZTGQY-UHFFFAOYSA-N 50568107 CHEMBL4845736 Ribosomal protein S6 kinase alpha-3 Homo sapiens 329 ChEMBL 10.1016/j.bmc.2021.116220 10.7270/Q2H70KKB 34034149 Casalvieri, KA; Matheson, CJ; Warfield, BM; Backos, DS; Reigan, P University of Colorado Anschutz Medical Campus http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50568107 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50568107&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 164608944 471058252 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 51406027 Oc1c(F)cc(Nc2ncc3ncn(-c4ccc(Oc5ccccc5)cc4)c3n2)cc1F InChI=1S/C23H15F2N5O2/c24-18-10-14(11-19(25)21(18)31)28-23-26-12-20-22(29-23)30(13-27-20)15-6-8-17(9-7-15)32-16-4-2-1-3-5-16/h1-13,31H,(H,26,28,29) LMOJDDMTQLQPPD-UHFFFAOYSA-N 50568108 CHEMBL4860957 Ribosomal protein S6 kinase alpha-3 Homo sapiens 148 ChEMBL 10.1016/j.bmc.2021.116220 10.7270/Q2H70KKB 34034149 Casalvieri, KA; Matheson, CJ; Warfield, BM; Backos, DS; Reigan, P University of Colorado Anschutz Medical Campus http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50568108 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50568108&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 164614775 471058253 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 51406028 Oc1cccc(c1)-n1cnc2cnc(Nc3cc(F)c(O)c(F)c3)nc12 InChI=1S/C17H11F2N5O2/c18-12-4-9(5-13(19)15(12)26)22-17-20-7-14-16(23-17)24(8-21-14)10-2-1-3-11(25)6-10/h1-8,25-26H,(H,20,22,23) MZDAVISMAIQLCR-UHFFFAOYSA-N 50568109 CHEMBL4861235 Ribosomal protein S6 kinase alpha-3 Homo sapiens 80 ChEMBL 10.1016/j.bmc.2021.116220 10.7270/Q2H70KKB 34034149 Casalvieri, KA; Matheson, CJ; Warfield, BM; Backos, DS; Reigan, P University of Colorado Anschutz Medical Campus http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50568109 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50568109&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 164615266 471058254 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 51406029 Oc1ccc(cc1)-n1cnc2cnc(Nc3cc(F)c(O)c(F)c3)nc12 InChI=1S/C17H11F2N5O2/c18-12-5-9(6-13(19)15(12)26)22-17-20-7-14-16(23-17)24(8-21-14)10-1-3-11(25)4-2-10/h1-8,25-26H,(H,20,22,23) REIKFAGJACMEBJ-UHFFFAOYSA-N 50568110 CHEMBL4865383 Ribosomal protein S6 kinase alpha-3 Homo sapiens 82 ChEMBL 10.1016/j.bmc.2021.116220 10.7270/Q2H70KKB 34034149 Casalvieri, KA; Matheson, CJ; Warfield, BM; Backos, DS; Reigan, P University of Colorado Anschutz Medical Campus http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50568110 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50568110&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 164621370 471058255 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 51406030 COC(=O)CCc1ccc(cc1)-n1cnc2cnc(Nc3cc(F)c(O)c(F)c3)nc12 InChI=1S/C21H17F2N5O3/c1-31-18(29)7-4-12-2-5-14(6-3-12)28-11-25-17-10-24-21(27-20(17)28)26-13-8-15(22)19(30)16(23)9-13/h2-3,5-6,8-11,30H,4,7H2,1H3,(H,24,26,27) DKBLAYGVRVTXEZ-UHFFFAOYSA-N 50568111 CHEMBL4878141 Ribosomal protein S6 kinase alpha-3 Homo sapiens 16 ChEMBL 10.1016/j.bmc.2021.116220 10.7270/Q2H70KKB 34034149 Casalvieri, KA; Matheson, CJ; Warfield, BM; Backos, DS; Reigan, P University of Colorado Anschutz Medical Campus http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50568111 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50568111&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 164627102 471058256 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 51406031 COC(=O)CCCc1ccc(cc1)-n1cnc2cnc(Nc3cc(F)c(O)c(F)c3)nc12 InChI=1S/C22H19F2N5O3/c1-32-19(30)4-2-3-13-5-7-15(8-6-13)29-12-26-18-11-25-22(28-21(18)29)27-14-9-16(23)20(31)17(24)10-14/h5-12,31H,2-4H2,1H3,(H,25,27,28) VRKGHNSJGKKFFV-UHFFFAOYSA-N 50568112 CHEMBL4851452 Ribosomal protein S6 kinase alpha-3 Homo sapiens 18 ChEMBL 10.1016/j.bmc.2021.116220 10.7270/Q2H70KKB 34034149 Casalvieri, KA; Matheson, CJ; Warfield, BM; Backos, DS; Reigan, P University of Colorado Anschutz Medical Campus http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50568112 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50568112&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 164617336 471058257 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 51406032 CC(C)CCn1ccc2cnc(Nc3cc(F)c(O)c(F)c3)nc12 InChI=1S/C17H18F2N4O/c1-10(2)3-5-23-6-4-11-9-20-17(22-16(11)23)21-12-7-13(18)15(24)14(19)8-12/h4,6-10,24H,3,5H2,1-2H3,(H,20,21,22) XFHMRDJYQKKGHA-UHFFFAOYSA-N 50568113 CHEMBL4873445 Ribosomal protein S6 kinase alpha-3 Homo sapiens 96 ChEMBL 10.1016/j.bmc.2021.116220 10.7270/Q2H70KKB 34034149 Casalvieri, KA; Matheson, CJ; Warfield, BM; Backos, DS; Reigan, P University of Colorado Anschutz Medical Campus http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50568113 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50568113&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 164625369 471058258 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 51406033 Oc1c(F)cc(Nc2ncc3ccn(-c4ccc(cc4)N4CCOCC4)c3n2)cc1F InChI=1S/C22H19F2N5O2/c23-18-11-15(12-19(24)20(18)30)26-22-25-13-14-5-6-29(21(14)27-22)17-3-1-16(2-4-17)28-7-9-31-10-8-28/h1-6,11-13,30H,7-10H2,(H,25,26,27) CACKGVOWAJCUIK-UHFFFAOYSA-N 50568114 CHEMBL4857399 Ribosomal protein S6 kinase alpha-3 Homo sapiens 26 ChEMBL 10.1016/j.bmc.2021.116220 10.7270/Q2H70KKB 34034149 Casalvieri, KA; Matheson, CJ; Warfield, BM; Backos, DS; Reigan, P University of Colorado Anschutz Medical Campus http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50568114 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50568114&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 164613064 471058259 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 51406034 CN1CCN(CC1)c1ccc(cc1)-n1ccc2cnc(Nc3cc(F)c(O)c(F)c3)nc12 InChI=1S/C23H22F2N6O/c1-29-8-10-30(11-9-29)17-2-4-18(5-3-17)31-7-6-15-14-26-23(28-22(15)31)27-16-12-19(24)21(32)20(25)13-16/h2-7,12-14,32H,8-11H2,1H3,(H,26,27,28) HFYKPLLUZVWVOL-UHFFFAOYSA-N 50568115 CHEMBL4864190 Ribosomal protein S6 kinase alpha-3 Homo sapiens 35 ChEMBL 10.1016/j.bmc.2021.116220 10.7270/Q2H70KKB 34034149 Casalvieri, KA; Matheson, CJ; Warfield, BM; Backos, DS; Reigan, P University of Colorado Anschutz Medical Campus http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50568115 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50568115&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 164619595 471058260 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 51406035 CC(C)CCN1C(C)C(=O)N(C)c2cnc(Nc3cc(F)c(O)c(F)c3)nc12 InChI=1S/C19H23F2N5O2/c1-10(2)5-6-26-11(3)18(28)25(4)15-9-22-19(24-17(15)26)23-12-7-13(20)16(27)14(21)8-12/h7-11,27H,5-6H2,1-4H3,(H,22,23,24) DTEKTGDVSARYDS-UHFFFAOYSA-N 25017 2-[(3,5-difluoro-4-hydroxyphenyl)amino]-5,7-dimethyl-8-(3-methylbutyl)-5,6,7,8-tetrahydropteridin-6-one::BI-D1870 Ribosomal protein S6 kinase alpha-3 Homo sapiens 2600 ChEMBL 10.1016/j.bmc.2021.116220 10.7270/Q2H70KKB 34034149 Casalvieri, KA; Matheson, CJ; Warfield, BM; Backos, DS; Reigan, P University of Colorado Anschutz Medical Campus http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25017 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25017&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 584 5WIK,5D9K,7N7L 25023738 56374161 ZINC33359423 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 51406036 CC(C)CCn1cnc2cnc(Nc3cc(F)c(O)c(F)c3)nc12 InChI=1S/C16H17F2N5O/c1-9(2)3-4-23-8-20-13-7-19-16(22-15(13)23)21-10-5-11(17)14(24)12(18)6-10/h5-9,24H,3-4H2,1-2H3,(H,19,21,22) OYTSXCFOGSTFSE-UHFFFAOYSA-N 50568104 CHEMBL4858257 Ribosomal protein S6 kinase alpha-3 Homo sapiens 970 ChEMBL 10.1016/j.bmc.2021.116220 10.7270/Q2H70KKB 34034149 Casalvieri, KA; Matheson, CJ; Warfield, BM; Backos, DS; Reigan, P University of Colorado Anschutz Medical Campus http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50568104 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50568104&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 164609895 471058249 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 51406037 Oc1c(F)cc(Nc2ncc3ncn(-c4ccc(CCN5CCOCC5)cc4)c3n2)cc1F InChI=1S/C23H22F2N6O2/c24-18-11-16(12-19(25)21(18)32)28-23-26-13-20-22(29-23)31(14-27-20)17-3-1-15(2-4-17)5-6-30-7-9-33-10-8-30/h1-4,11-14,32H,5-10H2,(H,26,28,29) UWGYODGLBGTABR-UHFFFAOYSA-N 50568106 CHEMBL4849660 Ribosomal protein S6 kinase alpha-3 Homo sapiens 1900 ChEMBL 10.1016/j.bmc.2021.116220 10.7270/Q2H70KKB 34034149 Casalvieri, KA; Matheson, CJ; Warfield, BM; Backos, DS; Reigan, P University of Colorado Anschutz Medical Campus http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50568106 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50568106&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 164611094 471058251 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 51406038 COC(=O)CCCc1ccc(cc1)-n1cnc2cnc(Nc3cc(F)c(O)c(F)c3)nc12 InChI=1S/C22H19F2N5O3/c1-32-19(30)4-2-3-13-5-7-15(8-6-13)29-12-26-18-11-25-22(28-21(18)29)27-14-9-16(23)20(31)17(24)10-14/h5-12,31H,2-4H2,1H3,(H,25,27,28) VRKGHNSJGKKFFV-UHFFFAOYSA-N 50568112 CHEMBL4851452 Ribosomal protein S6 kinase alpha-3 Homo sapiens 13900 ChEMBL 10.1016/j.bmc.2021.116220 10.7270/Q2H70KKB 34034149 Casalvieri, KA; Matheson, CJ; Warfield, BM; Backos, DS; Reigan, P University of Colorado Anschutz Medical Campus http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50568112 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50568112&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 164617336 471058257 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 51406039 CC(C)CCn1ccc2cnc(Nc3cc(F)c(O)c(F)c3)nc12 InChI=1S/C17H18F2N4O/c1-10(2)3-5-23-6-4-11-9-20-17(22-16(11)23)21-12-7-13(18)15(24)14(19)8-12/h4,6-10,24H,3,5H2,1-2H3,(H,20,21,22) XFHMRDJYQKKGHA-UHFFFAOYSA-N 50568113 CHEMBL4873445 Ribosomal protein S6 kinase alpha-3 Homo sapiens 1300 ChEMBL 10.1016/j.bmc.2021.116220 10.7270/Q2H70KKB 34034149 Casalvieri, KA; Matheson, CJ; Warfield, BM; Backos, DS; Reigan, P University of Colorado Anschutz Medical Campus http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50568113 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50568113&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 164625369 471058258 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 51406040 Oc1c(F)cc(Nc2ncc3ccn(-c4ccc(cc4)N4CCOCC4)c3n2)cc1F InChI=1S/C22H19F2N5O2/c23-18-11-15(12-19(24)20(18)30)26-22-25-13-14-5-6-29(21(14)27-22)17-3-1-16(2-4-17)28-7-9-31-10-8-28/h1-6,11-13,30H,7-10H2,(H,25,26,27) CACKGVOWAJCUIK-UHFFFAOYSA-N 50568114 CHEMBL4857399 Ribosomal protein S6 kinase alpha-3 Homo sapiens 230 ChEMBL 10.1016/j.bmc.2021.116220 10.7270/Q2H70KKB 34034149 Casalvieri, KA; Matheson, CJ; Warfield, BM; Backos, DS; Reigan, P University of Colorado Anschutz Medical Campus http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50568114 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50568114&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 164613064 471058259 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 51406041 CN1CCN(CC1)c1ccc(cc1)-n1ccc2cnc(Nc3cc(F)c(O)c(F)c3)nc12 InChI=1S/C23H22F2N6O/c1-29-8-10-30(11-9-29)17-2-4-18(5-3-17)31-7-6-15-14-26-23(28-22(15)31)27-16-12-19(24)21(32)20(25)13-16/h2-7,12-14,32H,8-11H2,1H3,(H,26,27,28) HFYKPLLUZVWVOL-UHFFFAOYSA-N 50568115 CHEMBL4864190 Ribosomal protein S6 kinase alpha-3 Homo sapiens 70 ChEMBL 10.1016/j.bmc.2021.116220 10.7270/Q2H70KKB 34034149 Casalvieri, KA; Matheson, CJ; Warfield, BM; Backos, DS; Reigan, P University of Colorado Anschutz Medical Campus http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50568115 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50568115&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 164619595 471058260 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 51419908 CN(C)C\C=C\C(=O)Nc1ccc(O[C@@H]2CCC[C@H](C2)Nc2ncc(Cl)c(n2)-c2c[nH]c3ccccc23)cc1 50573518 CHEMBL4754873 Ribosomal protein S6 kinase alpha-3 Homo sapiens 4500 ChEMBL 10.1016/j.ejmech.2021.113481 10.7270/Q22B92TP 33945934 Jiang, B; Jiang, J; Kaltheuner, IH; Iniguez, AB; Anand, K; Ferguson, FM; Ficarro, SB; Seong, BKA; Greifenberg, AK; Dust, S; Kwiatkowski, NP; Marto, JA; Stegmaier, K; Zhang, T; Geyer, M; Gray, NS Harvard Medical School http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573518 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573518&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search UUB 7NXK 134560325 471063663 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 51430724 CC(C)CCN1C(C)C(=O)N(C)c2cnc(Nc3cc(F)c(O)c(F)c3)nc12 InChI=1S/C19H23F2N5O2/c1-10(2)5-6-26-11(3)18(28)25(4)15-9-22-19(24-17(15)26)23-12-7-13(20)16(27)14(21)8-12/h7-11,27H,5-6H2,1-4H3,(H,22,23,24) DTEKTGDVSARYDS-UHFFFAOYSA-N 25017 2-[(3,5-difluoro-4-hydroxyphenyl)amino]-5,7-dimethyl-8-(3-methylbutyl)-5,6,7,8-tetrahydropteridin-6-one::BI-D1870 Ribosomal protein S6 kinase alpha-3 Homo sapiens 24 ChEMBL 10.1021/acs.jmedchem.1c00969 10.7270/Q2WD44DC 34496560 Yuan, Y; Xu, J; Jiang, L; Yu, K; Ge, Y; Li, M; He, H; Niu, Q; Shi, X; Fan, L; Chen, Z; Zhao, Z; Li, S; Xu, Y; Wang, Z; Li, H East China University of Science & Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25017 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25017&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 584 5WIK,5D9K,7N7L 25023738 56374161 ZINC33359423 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 51430729 CN1CCN(CC1)c1ccc(cc1)-c1ccncc1-c1cc(F)c(O)c(F)c1 InChI=1S/C22H21F2N3O/c1-26-8-10-27(11-9-26)17-4-2-15(3-5-17)18-6-7-25-14-19(18)16-12-20(23)22(28)21(24)13-16/h2-7,12-14,28H,8-11H2,1H3 IKUFKDGKRLMXEX-UHFFFAOYSA-N 50111385 CHEMBL3604793 Ribosomal protein S6 kinase alpha-3 Homo sapiens 4.0 ChEMBL 10.1021/acs.jmedchem.1c00969 10.7270/Q2WD44DC 34496560 Yuan, Y; Xu, J; Jiang, L; Yu, K; Ge, Y; Li, M; He, H; Niu, Q; Shi, X; Fan, L; Chen, Z; Zhao, Z; Li, S; Xu, Y; Wang, Z; Li, H East China University of Science & Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50111385 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50111385&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 2NK 4NUS 73010393 104005993 CHEMBL3604793 ZINC13440451 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 51430730 Oc1c(F)cc(cc1F)-c1cnccc1-c1ccc(cc1)N1CCOCC1 InChI=1S/C21H18F2N2O2/c22-19-11-15(12-20(23)21(19)26)18-13-24-6-5-17(18)14-1-3-16(4-2-14)25-7-9-27-10-8-25/h1-6,11-13,26H,7-10H2 YUYJEQHNWKQNBT-UHFFFAOYSA-N 50111384 CHEMBL3604794 Ribosomal protein S6 kinase alpha-3 Homo sapiens 6.0 ChEMBL 10.1021/acs.jmedchem.1c00969 10.7270/Q2WD44DC 34496560 Yuan, Y; Xu, J; Jiang, L; Yu, K; Ge, Y; Li, M; He, H; Niu, Q; Shi, X; Fan, L; Chen, Z; Zhao, Z; Li, S; Xu, Y; Wang, Z; Li, H East China University of Science & Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50111384 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50111384&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 118704762 104005992 CHEMBL3604794 ZINC13440454 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 51430733 Cc1ccc(cc1)-c1c(C(=O)CF)n(CCCO)c2ncnc(N)c12 InChI=1S/C18H19FN4O2/c1-11-3-5-12(6-4-11)14-15-17(20)21-10-22-18(15)23(7-2-8-24)16(14)13(25)9-19/h3-6,10,24H,2,7-9H2,1H3,(H2,20,21,22) IKLGYJACVCXYIL-UHFFFAOYSA-N 50248765 1-(4-amino-7-(3-hydroxypropyl)-5-p-tolyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl)-2-fluoroethanone::CHEMBL515414 Ribosomal protein S6 kinase alpha-3 Homo sapiens 15 ChEMBL 10.1021/acs.jmedchem.1c00969 10.7270/Q2WD44DC 34496560 Yuan, Y; Xu, J; Jiang, L; Yu, K; Ge, Y; Li, M; He, H; Niu, Q; Shi, X; Fan, L; Chen, Z; Zhao, Z; Li, S; Xu, Y; Wang, Z; Li, H East China University of Science & Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50248765 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50248765&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 644243 104103317 CHEMBL515414 ZINC06718642 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 51448350 CN1Cc2nn(C)c(C#N)c2-c2cnc3[nH]c(F)c(-c4cn(CCCC1=O)nc4C(F)(F)F)c3c2 50585046 CHEMBL5086263 Ribosomal protein S6 kinase alpha-3 Homo sapiens 182 ChEMBL 10.1021/acsmedchemlett.1c00630 10.7270/Q2183BDB 35450378 Powell, CE; Hatcher, JM; Jiang, J; Vatsan, PS; Che, J; Gray, NS Dana-Farber Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50585046 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50585046&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 166633521 476021133 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 51448357 CN1Cc2nn(C)c(C#N)c2-c2cnc3[nH]c(F)c(-c4cn(CCCC1=O)nc4C(F)(F)F)c3c2 50585046 CHEMBL5086263 Ribosomal protein S6 kinase alpha-3 Homo sapiens 80 ChEMBL 10.1021/acsmedchemlett.1c00630 10.7270/Q2183BDB 35450378 Powell, CE; Hatcher, JM; Jiang, J; Vatsan, PS; Che, J; Gray, NS Dana-Farber Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50585046 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50585046&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 166633521 476021133 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 51509954 NC(=O)C(=C/c1cccc(c1)-c1ncnc2[nH]ccc12)\C#N InChI=1S/C16H11N5O/c17-8-12(15(18)22)7-10-2-1-3-11(6-10)14-13-4-5-19-16(13)21-9-20-14/h1-7,9H,(H2,18,22)(H,19,20,21)/b12-7- PBACTZXZNFJQGT-GHXNOFRVSA-N 50607924 CHEMBL5278864 Ribosomal protein S6 kinase alpha-3 Homo sapiens 399 ChEMBL 10.7270/Q2ZW1R4J 32971426 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50607924 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50607924&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 171357400 494497672 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 51509955 NC(=O)C(=C\c1cc(cc(c1)C(F)(F)F)C(F)(F)F)\C#N InChI=1S/C12H6F6N2O/c13-11(14,15)8-2-6(1-7(5-19)10(20)21)3-9(4-8)12(16,17)18/h1-4H,(H2,20,21)/b7-1+ PGZKKYMEBFZCMM-LREOWRDNSA-N 50607925 CHEMBL5270221 Ribosomal protein S6 kinase alpha-3 Homo sapiens 399 ChEMBL 10.7270/Q2ZW1R4J 32971426 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50607925 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50607925&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 129051175 494497673 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 51525329 CC(C)CCN1C(C)C(=O)N(C)c2cnc(Nc3cc(F)c(O)c(F)c3)nc12 InChI=1S/C19H23F2N5O2/c1-10(2)5-6-26-11(3)18(28)25(4)15-9-22-19(24-17(15)26)23-12-7-13(20)16(27)14(21)8-12/h7-11,27H,5-6H2,1-4H3,(H,22,23,24) DTEKTGDVSARYDS-UHFFFAOYSA-N 25017 2-[(3,5-difluoro-4-hydroxyphenyl)amino]-5,7-dimethyl-8-(3-methylbutyl)-5,6,7,8-tetrahydropteridin-6-one::BI-D1870::US11851436, Compound BI-D1870 Ribosomal protein S6 kinase alpha-3 Homo sapiens 24 ChEMBL 10.7270/Q2GX4GVS 27559828 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25017 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25017&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 584 5WIK,5D9K,7N7L 25023738 56374161 ZINC33359423 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 1361700 CC(C)CCN1C(C)C(=O)N(C)c2cnc(Nc3cc(F)c(O)c(F)c3)nc12 InChI=1S/C19H23F2N5O2/c1-10(2)5-6-26-11(3)18(28)25(4)15-9-22-19(24-17(15)26)23-12-7-13(20)16(27)14(21)8-12/h7-11,27H,5-6H2,1-4H3,(H,22,23,24) DTEKTGDVSARYDS-UHFFFAOYSA-N 25017 2-[(3,5-difluoro-4-hydroxyphenyl)amino]-5,7-dimethyl-8-(3-methylbutyl)-5,6,7,8-tetrahydropteridin-6-one::BI-D1870::US11851436, Compound BI-D1870 Ribosomal protein S6 kinase alpha-3 Homo sapiens 22.6 US Patent 10.7270/Q2668JBP US11851436 Reigan, P; Casalvieri, KA The Regents Of The University Of Colorado, A Body Corporate http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25017 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25017&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 584 5WIK,5D9K,7N7L 25023738 56374161 ZINC33359423 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 1361701 Oc1c(F)cc(Nc2ncc3nc[nH]c3n2)cc1F InChI=1S/C11H7F2N5O/c12-6-1-5(2-7(13)9(6)19)17-11-14-3-8-10(18-11)16-4-15-8/h1-4,19H,(H2,14,15,16,17,18) NESFHNRJRFLAMW-UHFFFAOYSA-N 642518 US11851436, Compound A1-1 Ribosomal protein S6 kinase alpha-3 Homo sapiens 55.5 US Patent 10.7270/Q2668JBP US11851436 Reigan, P; Casalvieri, KA The Regents Of The University Of Colorado, A Body Corporate http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=642518 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=642518&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 164627508 488875373 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 1361702 CC(C)CCn1cnc2cnc(Nc3cc(F)c(O)c(F)c3)nc12 InChI=1S/C16H17F2N5O/c1-9(2)3-4-23-8-20-13-7-19-16(22-15(13)23)21-10-5-11(17)14(24)12(18)6-10/h5-9,24H,3-4H2,1-2H3,(H,19,21,22) OYTSXCFOGSTFSE-UHFFFAOYSA-N 50568104 CHEMBL4858257::US11851436, Compound A1-2 Ribosomal protein S6 kinase alpha-3 Homo sapiens 24.6 US Patent 10.7270/Q2668JBP US11851436 Reigan, P; Casalvieri, KA The Regents Of The University Of Colorado, A Body Corporate http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50568104 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50568104&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 164609895 471058249 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 1361703 Oc1c(F)cc(Nc2ncc3ncn(-c4ccc(cc4)N4CCOCC4)c3n2)cc1F InChI=1S/C21H18F2N6O2/c22-16-9-13(10-17(23)19(16)30)26-21-24-11-18-20(27-21)29(12-25-18)15-3-1-14(2-4-15)28-5-7-31-8-6-28/h1-4,9-12,30H,5-8H2,(H,24,26,27) AZIATJQXGGRMIL-UHFFFAOYSA-N 50568105 CHEMBL4858455::US11851436, Compound A1-3 Ribosomal protein S6 kinase alpha-3 Homo sapiens 18.4 US Patent 10.7270/Q2668JBP US11851436 Reigan, P; Casalvieri, KA The Regents Of The University Of Colorado, A Body Corporate http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50568105 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50568105&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 164613626 471058250 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 1361704 Oc1c(F)cc(Nc2ncc3ncn(-c4ccc(CCN5CCOCC5)cc4)c3n2)cc1F InChI=1S/C23H22F2N6O2/c24-18-11-16(12-19(25)21(18)32)28-23-26-13-20-22(29-23)31(14-27-20)17-3-1-15(2-4-17)5-6-30-7-9-33-10-8-30/h1-4,11-14,32H,5-10H2,(H,26,28,29) UWGYODGLBGTABR-UHFFFAOYSA-N 50568106 CHEMBL4849660::US11851436, Compound A1-4 Ribosomal protein S6 kinase alpha-3 Homo sapiens 329 US Patent 10.7270/Q2668JBP US11851436 Reigan, P; Casalvieri, KA The Regents Of The University Of Colorado, A Body Corporate http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50568106 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50568106&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 164611094 471058251 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 1361705 Oc1c(F)cc(Nc2ncc3ncn(-c4ccc(cc4)-c4ccccc4)c3n2)cc1F InChI=1S/C23H15F2N5O/c24-18-10-16(11-19(25)21(18)31)28-23-26-12-20-22(29-23)30(13-27-20)17-8-6-15(7-9-17)14-4-2-1-3-5-14/h1-13,31H,(H,26,28,29) TZXQNSOFAGUOOX-UHFFFAOYSA-N 642522 US11851436, Compound A1-5 Ribosomal protein S6 kinase alpha-3 Homo sapiens 148 US Patent 10.7270/Q2668JBP US11851436 Reigan, P; Casalvieri, KA The Regents Of The University Of Colorado, A Body Corporate http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=642522 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=642522&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 164616659 488875377 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 1361706 Oc1c(F)cc(Nc2ncc3ncn(-c4cccc(Oc5ccccc5)c4)c3n2)cc1F InChI=1S/C23H15F2N5O2/c24-18-9-14(10-19(25)21(18)31)28-23-26-12-20-22(29-23)30(13-27-20)15-5-4-8-17(11-15)32-16-6-2-1-3-7-16/h1-13,31H,(H,26,28,29) KVYJDRGXUZTGQY-UHFFFAOYSA-N 50568107 CHEMBL4845736::US11851436, Compound A1-6 Ribosomal protein S6 kinase alpha-3 Homo sapiens 79.8 US Patent 10.7270/Q2668JBP US11851436 Reigan, P; Casalvieri, KA The Regents Of The University Of Colorado, A Body Corporate http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50568107 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50568107&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 164608944 471058252 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 1361707 Oc1c(F)cc(Nc2ncc3ncn(-c4ccc(Oc5ccccc5)cc4)c3n2)cc1F InChI=1S/C23H15F2N5O2/c24-18-10-14(11-19(25)21(18)31)28-23-26-12-20-22(29-23)30(13-27-20)15-6-8-17(9-7-15)32-16-4-2-1-3-5-16/h1-13,31H,(H,26,28,29) LMOJDDMTQLQPPD-UHFFFAOYSA-N 50568108 CHEMBL4860957::US11851436, Compound A1-7 Ribosomal protein S6 kinase alpha-3 Homo sapiens 81.8 US Patent 10.7270/Q2668JBP US11851436 Reigan, P; Casalvieri, KA The Regents Of The University Of Colorado, A Body Corporate http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50568108 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50568108&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 164614775 471058253 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 1361708 Oc1c(F)cc(Nc2ncc3ncn(-c4cccc(OCc5ccccc5)c4)c3n2)cc1F InChI=1S/C24H17F2N5O2/c25-19-9-16(10-20(26)22(19)32)29-24-27-12-21-23(30-24)31(14-28-21)17-7-4-8-18(11-17)33-13-15-5-2-1-3-6-15/h1-12,14,32H,13H2,(H,27,29,30) PQMZMXOSIASYBS-UHFFFAOYSA-N 642525 US11851436, Compound A1-8 Ribosomal protein S6 kinase alpha-3 Homo sapiens 15.7 US Patent 10.7270/Q2668JBP US11851436 Reigan, P; Casalvieri, KA The Regents Of The University Of Colorado, A Body Corporate http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=642525 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=642525&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 164619437 488875380 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 1361709 Oc1c(F)cc(Nc2ncc3ncn(-c4ccc(OCc5ccccc5)cc4)c3n2)cc1F InChI=1S/C24H17F2N5O2/c25-19-10-16(11-20(26)22(19)32)29-24-27-12-21-23(30-24)31(14-28-21)17-6-8-18(9-7-17)33-13-15-4-2-1-3-5-15/h1-12,14,32H,13H2,(H,27,29,30) PZJTYNJLNJLDJE-UHFFFAOYSA-N 642526 US11851436, Compound A1-9 Ribosomal protein S6 kinase alpha-3 Homo sapiens 17.8 US Patent 10.7270/Q2668JBP US11851436 Reigan, P; Casalvieri, KA The Regents Of The University Of Colorado, A Body Corporate http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=642526 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=642526&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 164629223 488875381 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 1361710 Oc1cccc(c1)-n1cnc2cnc(Nc3cc(F)c(O)c(F)c3)nc12 InChI=1S/C17H11F2N5O2/c18-12-4-9(5-13(19)15(12)26)22-17-20-7-14-16(23-17)24(8-21-14)10-2-1-3-11(25)6-10/h1-8,25-26H,(H,20,22,23) MZDAVISMAIQLCR-UHFFFAOYSA-N 50568109 CHEMBL4861235::US11851436, Compound A1-10 Ribosomal protein S6 kinase alpha-3 Homo sapiens 95.8 US Patent 10.7270/Q2668JBP US11851436 Reigan, P; Casalvieri, KA The Regents Of The University Of Colorado, A Body Corporate http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50568109 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50568109&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 164615266 471058254 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 1361711 Oc1ccc(cc1)-n1cnc2cnc(Nc3cc(F)c(O)c(F)c3)nc12 InChI=1S/C17H11F2N5O2/c18-12-5-9(6-13(19)15(12)26)22-17-20-7-14-16(23-17)24(8-21-14)10-1-3-11(25)4-2-10/h1-8,25-26H,(H,20,22,23) REIKFAGJACMEBJ-UHFFFAOYSA-N 50568110 CHEMBL4865383::US11851436, Compound A1-11 Ribosomal protein S6 kinase alpha-3 Homo sapiens 25.7 US Patent 10.7270/Q2668JBP US11851436 Reigan, P; Casalvieri, KA The Regents Of The University Of Colorado, A Body Corporate http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50568110 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50568110&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 164621370 471058255 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 1361712 COC(=O)CCc1ccc(cc1)-n1cnc2cnc(Nc3cc(F)c(O)c(F)c3)nc12 InChI=1S/C21H17F2N5O3/c1-31-18(29)7-4-12-2-5-14(6-3-12)28-11-25-17-10-24-21(27-20(17)28)26-13-8-15(22)19(30)16(23)9-13/h2-3,5-6,8-11,30H,4,7H2,1H3,(H,24,26,27) DKBLAYGVRVTXEZ-UHFFFAOYSA-N 50568111 CHEMBL4878141::US11851436, Compound A1-12 Ribosomal protein S6 kinase alpha-3 Homo sapiens 34.7 US Patent 10.7270/Q2668JBP US11851436 Reigan, P; Casalvieri, KA The Regents Of The University Of Colorado, A Body Corporate http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50568111 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50568111&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 164627102 471058256 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 4NUS,4NW5,4NW6,5D9K,5D9L,7OPO Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 51549163 CCS(=O)(=O)N1CCN(CC1)c1ccc(Nc2ncc(C(N)=O)c(NC3CC3)n2)cc1 InChI=1S/C20H27N7O3S/c1-2-31(29,30)27-11-9-26(10-12-27)16-7-5-15(6-8-16)24-20-22-13-17(18(21)28)19(25-20)23-14-3-4-14/h5-8,13-14H,2-4,9-12H2,1H3,(H2,21,28)(H2,22,23,24,25) BGLPECHZZQDNCD-UHFFFAOYSA-N 50468574 CHEMBL4116008::US11414410, Example 100 Ribosomal protein S6 kinase alpha-3 Homo sapiens 4.0 ChEMBL 10.1016/j.ejmech.2022.114551 10.7270/Q23F4V2S 35749986 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50468574 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50468574&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search S5I 8BX6 44595079 433935839 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 5D9K,3G51,5D9L,4NW6,4NW5,4NUS,8XFY,8R58,7OPO,8EQ5,4GUE,4EL9,3UBD Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 51557058 C[C@@H]1O[C@@H](Oc2c(O)c3c(cc(O)cc3=O)oc2-c2ccc(O)cc2)[C@H](O)[C@H](OC(C)=O)[C@H]1OC(C)=O InChI=1S/C25H24O12/c1-10-21(34-11(2)26)24(35-12(3)27)20(32)25(33-10)37-23-19(31)18-16(30)8-15(29)9-17(18)36-22(23)13-4-6-14(28)7-5-13/h4-10,20-21,24-25,28-29,31-32H,1-3H3/t10-,20+,21-,24-,25-/m0/s1 POZDUGKSCAGWQI-IGKKHSBFSA-N 50241294 CHEMBL240954::SL-0101::kaempferol 3-O-(3'',4''-di-O-acetyl-alpha-L-rhamnopyranoside::kaempferol-3-O-(3,4-di-O-acetyl-alpha-L-rhamnopyranoside) Ribosomal protein S6 kinase alpha-3 Homo sapiens 1710 ChEMBL 10.1016/j.ejmech.2023.115229 10.7270/Q2DF6WMX 36898330 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50241294 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50241294&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 10459196 104098696 CHEMBL240954 ZINC28875874 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 5D9K,3G51,5D9L,4NW6,4NW5,4NUS,8XFY,8R58,7OPO,8EQ5,4GUE,4EL9,3UBD Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 51557059 CCC[C@@H]1O[C@@H](Oc2c(oc3cc(O)cc(O)c3c2=O)-c2ccc(O)cc2)[C@H](OC(C)=O)[C@H](OC(C)=O)[C@H]1NC(C)=O InChI=1S/C29H31NO12/c1-5-6-20-23(30-13(2)31)26(38-14(3)32)28(39-15(4)33)29(41-20)42-27-24(37)22-19(36)11-18(35)12-21(22)40-25(27)16-7-9-17(34)10-8-16/h7-12,20,23,26,28-29,34-36H,5-6H2,1-4H3,(H,30,31)/t20-,23-,26+,28+,29-/m0/s1 FHLIWWVDMNVOJR-YXYCDYAJSA-N 50626653 CHEMBL5419696 Ribosomal protein S6 kinase alpha-3 Homo sapiens 440 ChEMBL 10.1016/j.ejmech.2023.115229 10.7270/Q2DF6WMX 36898330 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50626653 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50626653&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 5D9K,3G51,5D9L,4NW6,4NW5,4NUS,8XFY,8R58,7OPO,8EQ5,4GUE,4EL9,3UBD Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 51557060 O=C1c2ccccc2-c2c(NCCc3ccccc3)c(=O)[nH]c3cccc1c23 InChI=1S/C24H18N2O2/c27-23-17-10-5-4-9-16(17)21-20-18(23)11-6-12-19(20)26-24(28)22(21)25-14-13-15-7-2-1-3-8-15/h1-12,25H,13-14H2,(H,26,28) XASCINRGTHLHGM-UHFFFAOYSA-N 50626652 CHEMBL4303592 Ribosomal protein S6 kinase alpha-3 Homo sapiens 2400 ChEMBL 10.1016/j.ejmech.2023.115229 10.7270/Q2DF6WMX 36898330 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50626652 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50626652&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 5D9K,3G51,5D9L,4NW6,4NW5,4NUS,8XFY,8R58,7OPO,8EQ5,4GUE,4EL9,3UBD Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 51557061 Oc1ccc2c(c1)oc(-c1ccc(O)c(O)c1)c(O)c2=O InChI=1S/C15H10O6/c16-8-2-3-9-12(6-8)21-15(14(20)13(9)19)7-1-4-10(17)11(18)5-7/h1-6,16-18,20H XHEFDIBZLJXQHF-UHFFFAOYSA-N 7457 2-(3,4-dihydroxyphenyl)-3,7-dihydroxy-4H-chromen-4-one::2-(3,4-dihydroxyphenyl)-3,7-dihydroxy-chromen-4-one::2-(3,4-dihydroxyphenyl)-3,7-dihydroxy-chromone;dihydrate::CHEMBL31574::Fisetin (14)::Fisetin, 15::fisetin Ribosomal protein S6 kinase alpha-3 Homo sapiens 2780 ChEMBL 10.1016/j.ejmech.2023.115229 10.7270/Q2DF6WMX 36898330 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=7457 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=7457&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search FSE 4RLT,3P0H,1XO2 5281614 11108248 42567 CHEMBL31574 DB07795 5182 C10041 ZINC00039111 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 5D9K,3G51,5D9L,4NW6,4NW5,4NUS,8XFY,8R58,7OPO,8EQ5,4GUE,4EL9,3UBD Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 51557062 CC(C)=CCC1C(=O)C(=O)c2ccccc2C1=O InChI=1S/C15H14O3/c1-9(2)7-8-12-13(16)10-5-3-4-6-11(10)14(17)15(12)18/h3-7,12H,8H2,1-2H3 KBTHDLHMTHCIHG-UHFFFAOYSA-N 50384788 LAPACHOL Ribosomal protein S6 kinase alpha-3 Homo sapiens 2000 ChEMBL 10.1016/j.ejmech.2023.115229 10.7270/Q2DF6WMX 36898330 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50384788 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50384788&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 44483359 160863871 ZINC03873071 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 5D9K,3G51,5D9L,4NW6,4NW5,4NUS,8XFY,8R58,7OPO,8EQ5,4GUE,4EL9,3UBD Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 51557063 CCCNC(=O)O[C@H]1[C@H](CCC)C[C@@H](Oc2c(oc3cc(O)cc(O)c3c2=O)-c2ccc(O)cc2)[C@H](O)[C@@H]1OC(=O)NCCC InChI=1S/C32H40N2O11/c1-4-7-18-14-23(25(38)29(45-32(41)34-13-6-3)28(18)44-31(40)33-12-5-2)43-30-26(39)24-21(37)15-20(36)16-22(24)42-27(30)17-8-10-19(35)11-9-17/h8-11,15-16,18,23,25,28-29,35-38H,4-7,12-14H2,1-3H3,(H,33,40)(H,34,41)/t18-,23-,25+,28+,29+/m1/s1 PENAALZGDCKICB-HNUOEALPSA-N 50626654 CHEMBL5401630 Ribosomal protein S6 kinase alpha-3 Homo sapiens 870 ChEMBL 10.1016/j.ejmech.2023.115229 10.7270/Q2DF6WMX 36898330 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50626654 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50626654&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 5D9K,3G51,5D9L,4NW6,4NW5,4NUS,8XFY,8R58,7OPO,8EQ5,4GUE,4EL9,3UBD Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 51557064 CCC[C@@H]1C[C@@H](Oc2c(oc3cc(O)cc(O)c3c2=O)-c2ccc(O)cc2)[C@H](O)[C@H](OC(C)=O)[C@H]1OC(C)=O InChI=1S/C28H30O11/c1-4-5-16-10-21(23(34)27(37-14(3)30)26(16)36-13(2)29)39-28-24(35)22-19(33)11-18(32)12-20(22)38-25(28)15-6-8-17(31)9-7-15/h6-9,11-12,16,21,23,26-27,31-34H,4-5,10H2,1-3H3/t16-,21-,23+,26+,27+/m1/s1 QLSWJTUDHCKJBC-DTSKBCQWSA-N 50626655 CHEMBL5439691 Ribosomal protein S6 kinase alpha-3 Homo sapiens 870 ChEMBL 10.1016/j.ejmech.2023.115229 10.7270/Q2DF6WMX 36898330 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50626655 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50626655&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 5D9K,3G51,5D9L,4NW6,4NW5,4NUS,8XFY,8R58,7OPO,8EQ5,4GUE,4EL9,3UBD Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 51557065 CCC[C@@H]1O[C@@H](Oc2c(O)c3c(cc(O)cc3=O)oc2-c2ccc(O)cc2)[C@H](O)[C@H](OC(C)=O)[C@H]1OC(C)=O InChI=1S/C27H28O12/c1-4-5-18-24(35-12(2)28)26(36-13(3)29)22(34)27(38-18)39-25-21(33)20-17(32)10-16(31)11-19(20)37-23(25)14-6-8-15(30)9-7-14/h6-11,18,22,24,26-27,30-31,33-34H,4-5H2,1-3H3/t18-,22+,24-,26-,27-/m0/s1 BWGPUSCWLCQDLW-ODHHTFEASA-N 50426389 CHEMBL2321925 Ribosomal protein S6 kinase alpha-3 Homo sapiens 20 ChEMBL 10.1016/j.ejmech.2023.115229 10.7270/Q2DF6WMX 36898330 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50426389 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50426389&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 71718779 164155264 CHEMBL2321925 ZINC95582689 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 5D9K,3G51,5D9L,4NW6,4NW5,4NUS,8XFY,8R58,7OPO,8EQ5,4GUE,4EL9,3UBD Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 51557066 Cc1ccc(cc1)-c1c(C(=O)CF)n(CCCO)c2ncnc(N)c12 InChI=1S/C18H19FN4O2/c1-11-3-5-12(6-4-11)14-15-17(20)21-10-22-18(15)23(7-2-8-24)16(14)13(25)9-19/h3-6,10,24H,2,7-9H2,1H3,(H2,20,21,22) IKLGYJACVCXYIL-UHFFFAOYSA-N 50248765 1-(4-amino-7-(3-hydroxypropyl)-5-p-tolyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl)-2-fluoroethanone::CHEMBL515414 Ribosomal protein S6 kinase alpha-3 Homo sapiens 15 ChEMBL 10.1016/j.ejmech.2023.115229 10.7270/Q2DF6WMX 36898330 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50248765 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50248765&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 644243 104103317 CHEMBL515414 ZINC06718642 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 5D9K,3G51,5D9L,4NW6,4NW5,4NUS,8XFY,8R58,7OPO,8EQ5,4GUE,4EL9,3UBD Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 51557067 Cc1ccc(cc1)-c1c(C(=O)CCl)n(CCCO)c2ncnc(N)c12 InChI=1S/C18H19ClN4O2/c1-11-3-5-12(6-4-11)14-15-17(20)21-10-22-18(15)23(7-2-8-24)16(14)13(25)9-19/h3-6,10,24H,2,7-9H2,1H3,(H2,20,21,22) PELFTNQHGSITLB-UHFFFAOYSA-N 50248767 1-(4-amino-7-(3-hydroxypropyl)-5-p-tolyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl)-2-chloroethanone::CHEMBL515416 Ribosomal protein S6 kinase alpha-3 Homo sapiens 15 ChEMBL 10.1016/j.ejmech.2023.115229 10.7270/Q2DF6WMX 36898330 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50248767 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50248767&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 16663089 104103319 CHEMBL515416 ZINC06718643 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 5D9K,3G51,5D9L,4NW6,4NW5,4NUS,8XFY,8R58,7OPO,8EQ5,4GUE,4EL9,3UBD Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 51557068 COC(=O)\C=C\C(=O)OC InChI=1S/C6H8O4/c1-9-5(7)3-4-6(8)10-2/h3-4H,1-2H3/b4-3+ LDCRTTXIJACKKU-ONEGZZNKSA-N 50504654 AZL 0 211089::AZL O 211089::AZL-0211089::AZL-O-211089::BG 00012::BG 12::BG-00012::BG-12::BG00012::CHEBI:76004::Dimethyl fumar::Dimethyl fumarate::FAG-201::FP-187::FP187::Fumaric acid dimethyl ester::LAS-41008::Las41008::NSC-167432::NSC-25942::Tecfidera Ribosomal protein S6 kinase alpha-3 Homo sapiens 225000 ChEMBL 10.1016/j.ejmech.2023.115229 10.7270/Q2DF6WMX 36898330 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504654 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504654&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search EOU 6LRZ 637568 440713239 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 5D9K,3G51,5D9L,4NW6,4NW5,4NUS,8XFY,8R58,7OPO,8EQ5,4GUE,4EL9,3UBD Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 51557069 O=C(Nc1cnn(Cc2ccncc2)c1)c1ccc2cc3C(=O)NCCCn3c2c1 InChI=1S/C22H20N6O2/c29-21(26-18-12-25-27(14-18)13-15-4-7-23-8-5-15)17-3-2-16-10-20-22(30)24-6-1-9-28(20)19(16)11-17/h2-5,7-8,10-12,14H,1,6,9,13H2,(H,24,30)(H,26,29) WKUUMSASAHOWGZ-UHFFFAOYSA-N 50360291 CHEMBL1933278::US9150577, 114 Ribosomal protein S6 kinase alpha-3 Homo sapiens 2.0 ChEMBL 10.1016/j.ejmech.2023.115229 10.7270/Q2DF6WMX 36898330 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50360291 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50360291&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 53247560 136964353 CHEMBL1933278 ZINC73224364 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 5D9K,3G51,5D9L,4NW6,4NW5,4NUS,8XFY,8R58,7OPO,8EQ5,4GUE,4EL9,3UBD Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 51557070 CN(C)CCCn1c(NC(=O)c2ccc3cc4C(=O)NCCCn4c3c2)nc2ccccc12 InChI=1S/C25H28N6O2/c1-29(2)12-6-14-31-20-8-4-3-7-19(20)27-25(31)28-23(32)18-10-9-17-15-22-24(33)26-11-5-13-30(22)21(17)16-18/h3-4,7-10,15-16H,5-6,11-14H2,1-2H3,(H,26,33)(H,27,28,32) KAKNBLVUBRXYQD-UHFFFAOYSA-N 50360296 CHEMBL1933283::US9150577, 96 Ribosomal protein S6 kinase alpha-3 Homo sapiens 12 ChEMBL 10.1016/j.ejmech.2023.115229 10.7270/Q2DF6WMX 36898330 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50360296 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50360296&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 57403971 136964358 CHEMBL1933283 ZINC73221640 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 5D9K,3G51,5D9L,4NW6,4NW5,4NUS,8XFY,8R58,7OPO,8EQ5,4GUE,4EL9,3UBD Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 51557071 CCn1c(NC(=O)c2ccc3cc4C(=O)NCCCn4c3c2)nc2ccc(Cl)cc12 InChI=1S/C22H20ClN5O2/c1-2-27-18-12-15(23)6-7-16(18)25-22(27)26-20(29)14-5-4-13-10-19-21(30)24-8-3-9-28(19)17(13)11-14/h4-7,10-12H,2-3,8-9H2,1H3,(H,24,30)(H,25,26,29) QYLAYPRSSJNQDC-UHFFFAOYSA-N 50360298 CHEMBL1933285::US9150577, 53 Ribosomal protein S6 kinase alpha-3 Homo sapiens 20 ChEMBL 10.1016/j.ejmech.2023.115229 10.7270/Q2DF6WMX 36898330 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50360298 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50360298&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 53247559 136964360 CHEMBL1933285 ZINC73222316 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 5D9K,3G51,5D9L,4NW6,4NW5,4NUS,8XFY,8R58,7OPO,8EQ5,4GUE,4EL9,3UBD Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 51557072 CN(C)CCCn1c(NC(=O)c2ccc3cc4C(=O)NCCCn4c3c2)nc2ccc(Cl)cc12 InChI=1S/C25H27ClN6O2/c1-30(2)10-4-12-32-21-15-18(26)7-8-19(21)28-25(32)29-23(33)17-6-5-16-13-22-24(34)27-9-3-11-31(22)20(16)14-17/h5-8,13-15H,3-4,9-12H2,1-2H3,(H,27,34)(H,28,29,33) VCZQSUBZCZZLAX-UHFFFAOYSA-N 50360299 CHEMBL1933286::US9150577, 54 Ribosomal protein S6 kinase alpha-3 Homo sapiens 20 ChEMBL 10.1016/j.ejmech.2023.115229 10.7270/Q2DF6WMX 36898330 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50360299 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50360299&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 57393506 136964361 CHEMBL1933286 ZINC73224075 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 5D9K,3G51,5D9L,4NW6,4NW5,4NUS,8XFY,8R58,7OPO,8EQ5,4GUE,4EL9,3UBD Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 51557073 C[C@@H]1CCNC(=O)c2cc3ccc(cc3n12)C(=O)Nc1nc2ccccc2n1CCCN(C)C InChI=1S/C26H30N6O2/c1-17-11-12-27-25(34)23-15-18-9-10-19(16-22(18)32(17)23)24(33)29-26-28-20-7-4-5-8-21(20)31(26)14-6-13-30(2)3/h4-5,7-10,15-17H,6,11-14H2,1-3H3,(H,27,34)(H,28,29,33)/t17-/m1/s1 ZHMXXVNQAFCXKK-QGZVFWFLSA-N 50360301 CHEMBL1933288::US9150577, 93 Ribosomal protein S6 kinase alpha-3 Homo sapiens 1.000000 ChEMBL 10.1016/j.ejmech.2023.115229 10.7270/Q2DF6WMX 36898330 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50360301 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50360301&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 53246941 136964363 CHEMBL1933288 ZINC82158487 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 5D9K,3G51,5D9L,4NW6,4NW5,4NUS,8XFY,8R58,7OPO,8EQ5,4GUE,4EL9,3UBD Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 51557074 C[C@@H]1CNC(=O)c2cc3ccc(nc3n12)C(=O)Nc1cnn(Cc2ccccc2)c1 InChI=1S/C22H20N6O2/c1-14-10-23-22(30)19-9-16-7-8-18(26-20(16)28(14)19)21(29)25-17-11-24-27(13-17)12-15-5-3-2-4-6-15/h2-9,11,13-14H,10,12H2,1H3,(H,23,30)(H,25,29)/t14-/m1/s1 GRKDQSJJVVIXFN-CQSZACIVSA-N 168025 US9073926, 59 Ribosomal protein S6 kinase alpha-3 Homo sapiens 0.200000 ChEMBL 10.1016/j.ejmech.2023.115229 10.7270/Q2DF6WMX 36898330 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168025 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168025&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 53230343 312525439 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 5D9K,3G51,5D9L,4NW6,4NW5,4NUS,8XFY,8R58,7OPO,8EQ5,4GUE,4EL9,3UBD Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 51557075 Oc1ccc(cc1)N=Nc1c(O)[nH]c(=O)[nH]c1=O InChI=1S/C10H8N4O4/c15-6-3-1-5(2-4-6)13-14-7-8(16)11-10(18)12-9(7)17/h1-4,15H,(H3,11,12,16,17,18) TWGOJILVCXFFAT-UHFFFAOYSA-N 50343656 5-(2-(4-hydroxyphenyl)hydrazono)pyrimidine-2,4,6(1H,3H,5H)-trione::CHEMBL1775071 Ribosomal protein S6 kinase alpha-3 Homo sapiens 1950 ChEMBL 10.1016/j.ejmech.2023.115229 10.7270/Q2DF6WMX 36898330 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50343656 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50343656&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 6025709 131346592 CHEMBL1775071 ZINC06863164 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 5D9K,3G51,5D9L,4NW6,4NW5,4NUS,8XFY,8R58,7OPO,8EQ5,4GUE,4EL9,3UBD Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 51557076 Oc1ccc(NN=C2C(=O)NC(=S)NC2=O)cc1 InChI=1S/C10H8N4O3S/c15-6-3-1-5(2-4-6)13-14-7-8(16)11-10(18)12-9(7)17/h1-4,13,15H,(H2,11,12,16,17,18) KRGHPEQKPRLYTJ-UHFFFAOYSA-N 241958 5-(2-(4-Hydroxyphenyl)hydrazono)-dihydro-2-thioxopyrimidine-4,6(1H,5H)-dione (14) Ribosomal protein S6 kinase alpha-3 Homo sapiens 2190 ChEMBL 10.1016/j.ejmech.2023.115229 10.7270/Q2DF6WMX 36898330 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=241958 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=241958&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search 5723450 341094211 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 5D9K,3G51,5D9L,4NW6,4NW5,4NUS,8XFY,8R58,7OPO,8EQ5,4GUE,4EL9,3UBD Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 51557079 Oc1ccc(cc1)-c1oc2cc(O)cc(O)c2c(=O)c1O InChI=1S/C15H10O6/c16-8-3-1-7(2-4-8)15-14(20)13(19)12-10(18)5-9(17)6-11(12)21-15/h1-6,16-18,20H IYRMWMYZSQPJKC-UHFFFAOYSA-N 7462 3,5,7-trihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one::3,5,7-trihydroxy-2-(4-hydroxyphenyl)-chromen-4-one::CHEMBL150::Kaempferol (18)::Kaempferol (Kmp)::cid_5280863::kaempferol Ribosomal protein S6 kinase alpha-3 Homo sapiens 1710 ChEMBL 10.1016/j.ejmech.2023.115229 10.7270/Q2DF6WMX 36898330 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=7462 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=7462&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search KMP 5AV2,4DET,5AUX,6M8B,5AV3,4REL,3QWH,8SFT,1H1M,7VEJ,2C1Z 5280863 11108253 28499 CHEMBL150 DB01852 C05903 ZINC03869768 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 5D9K,3G51,5D9L,4NW6,4NW5,4NUS,8XFY,8R58,7OPO,8EQ5,4GUE,4EL9,3UBD Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 51557080 Oc1cc(O)c2C(=O)C[C@H](Oc2c1)c1ccc(O)c(O)c1 InChI=1S/C15H12O6/c16-8-4-11(19)15-12(20)6-13(21-14(15)5-8)7-1-2-9(17)10(18)3-7/h1-5,13,16-19H,6H2/t13-/m0/s1 SBHXYTNGIZCORC-ZDUSSCGKSA-N 50325671 (2S)-2-(3,4-DIHYDROXYPHENYL)-5,7-DIHYDROXY-2,3-DIHYDRO-4H-CHROMEN-4-ONE::(S)-2-(3,4-Dihydroxy-phenyl)-5,7-dihydroxy-chroman-4-one::(S)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-2,3-dihydrochromen-4-one::(S)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxychroman-4-one::5,7,3',4'-tetrahydroxyflavanone::5,7,3',4'-tetrahydroxyflavon::CHEMBL8996::ERIODICTYOL::eriodicryol::eryodictiol::hsp90_170 Ribosomal protein S6 kinase alpha-3 Homo sapiens 4770 ChEMBL 10.1016/j.ejmech.2023.115229 10.7270/Q2DF6WMX 36898330 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50325671 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50325671&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search ERD 2NNL,8B3C,7YJB 440735 117646992 28412 CHEMBL8996 C05631 ZINC00058117 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 5D9K,3G51,5D9L,4NW6,4NW5,4NUS,8XFY,8R58,7OPO,8EQ5,4GUE,4EL9,3UBD Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 51557081 Oc1cc(O)c2c(c1)oc(cc2=O)-c1ccc(O)c(O)c1 InChI=1S/C15H10O6/c16-8-4-11(19)15-12(20)6-13(21-14(15)5-8)7-1-2-9(17)10(18)3-7/h1-6,16-19H IQPNAANSBPBGFQ-UHFFFAOYSA-N 7459 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one::2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-chromen-4-one::CHEMBL151::Luteolin (27)::Luteolin (4)::acs.jmedchem.1c00409_ST.600::cid_5280445::luteolin::med.21724, Compound 3 Ribosomal protein S6 kinase alpha-3 Homo sapiens 4420 ChEMBL 10.1016/j.ejmech.2023.115229 10.7270/Q2DF6WMX 36898330 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=7459 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2740&target=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=7459&enzyme=Ribosomal+protein+S6+kinase+alpha-3&column=ki&startPg=0&Increment=50&submit=Search LU2 4HKN,4QYA,6YA5,4DGN,5AUU,8I94,6M8A,4DEW,3SZ1,7D3B,7EBV,5II2,5NDF,8WR2,4QXV 5280445 11108250 15864 CHEMBL151 5215 C01514 ZINC18185774 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL 5D9K,3G51,5D9L,4NW6,4NW5,4NUS,8XFY,8R58,7OPO,8EQ5,4GUE,4EL9,3UBD Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7